Relevant bibliographies by topics / Site 334

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Academic literature on the topic 'Site 334'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 February 2022

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Journal articles on the topic "Site 334"

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Blum, Melissa A., Tivadar Orban, Daniel O. Beck, and Michael Kalafatis. "The Specific Contribution of Amino Acids 334 and 335 from Factor Va Heavy Chain to the Catalytic Efficiency of Prothrombinase." Blood 106, no. 11 (November 16, 2005): 1027. http://dx.doi.org/10.1182/blood.v106.11.1027.1027.

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Abstract The prothrombinase complex, composed of the enzyme factor Xa, the cofactor factor Va, and the substrate prothrombin associated on a cell surface in the presence of divalent metal ions, catalyzes the activation of prothrombin to thrombin 300,000-fold more effectively than the enzyme, factor Xa, alone. We have demonstrated that amino acids E323, Y324 and E330, V331 are binding sites for factor Xa on the factor Va heavy chain and are required for coordinating the spatial arrangement of enzyme and substrate directing prothrombin cleavage at two spatially distinct sites. We have also demonstrated that amino acid region 332–336 contains residues that are involved in cofactor function. Peptide studies have identified amino acid residues 334DY335 as major participants in factor Va cofactor activity. We have employed site-directed mutagenesis to study the effect of these amino acids on the catalytic efficiency of prothrombinase. Recombinant factor V molecules with the mutations D334K and Y335F, designated factor VKF, and D334A and Y335A, designated factor VAA were produced, transiently transfected, expressed in COS7L cells, and purified. Kinetic studies demonstrate that while factor VaKF has a KD for factor Xa similar to the KD observed for wild type factor Va, the kcat of prothrombinase assembled with factor VaKF has approximately a 1.5-fold decreased value compared to kcat of prothrombinase assembled with the wild type cofactor molecule. On the contrary, prothrombinase assembled with factor VaAA was found to have a nearly 10-fold decrease kcat, compared to prothrombinase assembled with wild type factor Va. This data suggest that not all amino acid substitutions are well tolerated at positions 334–335. Analysis of the sequence 323–340 using the recently published completed model of coagulation factor Va (pdb entry 1Y61) revealed that amino acids 334–335 are located at the end of a beta-sheet. To ascertain the importance of these mutants and their contribution to cofactor activity we have combined the mutations of amino acids 334–335 with mutations at amino acids 323–324 (E323F, Y324F) and 330–331 (E330M, V331I). We thus created quadruple mutants resulting in recombinant factor VFF/KF, factor VFF/AA, factor VMI/KF and factor VMI/AA. These molecules were transiently expressed in COS-7L cells and studied for their ability to be incorporated into prothrombinase. Free energies associated with the catalytic efficiencies of prothrombinase assembled with each mutant were also calculated (ΔΔGint). The ΔΔGint of interaction for the double mutants, factor VaFF/KF and factor VaMI/KF, had positive values indicating that the side chains of amino acids 330EV331, 323EY324 and 334DY335 located in and around the factor Xa binding site interact in a synergistic manner resulting in the destabilization of the transition state complex and a decelerated rate of catalysis. Conversely, combining the factor Xa binding site mutants with recombinant factor VaAA result in ΔΔGint values of approximately zero. In conclusion, the data demonstrate that replacement of amino acids 334–335 by two hydrophilic residues results in decreased cofactor function. In contrast, replacement of these amino acids by two small hydrophobic residues do not appear to be well tolerated by the cofactor resulting in severely impaired cofactor activity. Altogether, these data demonstrate the importance of amino acid residues D334 and Y335 for the rearrangement of enzyme and substrate required for efficient catalysis.
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Pollok-Kopp, Beatrix, Friederike Hüttenrauch, Stephanie Rethorn, and Martin Oppermann. "Dynamics of Protein Kinase C-mediated Phosphorylation of the Complement C5a Receptor on Serine 334." Journal of Biological Chemistry 282, no. 7 (December 4, 2006): 4345–53. http://dx.doi.org/10.1074/jbc.m601317200.

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Upon agonist binding, the C5a anaphylatoxin receptor (C5aR) is rapidly phosphorylated on phosphorylation sites that are located within the C-terminal domain of the receptor. Previous studies suggested that C5aR phosphorylation proceeds in a hierarchical manner with serine 334 presenting a highly accessible priming site that controls subsequent phosphorylation at other positions. To better understand the dynamics of Ser-334 phosphorylation, we generated site-specific monoclonal antibodies that specifically react with phosphoserine 334. In differentiated U937 cells, which endogenously express C5aR, stimulation with low C5a concentrations resulted in a very rapid (t½ ∼ 20 s), albeit transient, receptor phosphorylation. Whole cell phosphorylation assays with specific inhibitors as well as in vitro phosphorylation assays with recombinant enzymes and peptide substrates revealed that phosphorylation of Ser-334 is regulated by protein kinase C-β and a calyculin A-sensitive protein phosphatase. Surprisingly, at high concentrations (>10 nm) of C5a, the protein kinase C-mediated phosphorylation of Ser-334 was essentially blocked. This could be attributed to the even faster (t½ < 5 s) binding of β-arrestin to the receptor. Analysis of C5aR Ser/Ala mutants that possess a single intact serine residue either at position 334 or at neighboring positions 327, 332, or 338 revealed functional redundancy of C-terminal phosphorylation sites since all 4 serine residues could individually support C5aR internalization and desensitization. This study is among the first to analyze in a detailed manner, using a non-mutational approach, modifications of a defined phosphorylation site in a G protein-coupled receptor and to correlate these findings with functional parameters of receptor deactivation.
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Li, Lehong, Xuehui Geng, Michael Yonkunas, Anjey Su, Erik Densmore, Pei Tang, and Peter Drain. "Ligand-dependent Linkage of the ATP Site to Inhibition Gate Closure in the KATP Channel." Journal of General Physiology 126, no. 3 (August 29, 2005): 285–99. http://dx.doi.org/10.1085/jgp.200509289.

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Major advances have been made on the inhibition gate and ATP site of the Kir6.2 subunit of the KATP channel, but little is known about conformational coupling between the two. ATP site mutations dramatically disrupt ATP-dependent gating without effect on ligand-independent gating, observed as interconversions between active burst and inactive interburst conformations in the absence of ATP. This suggests that linkage between site and gate is conditionally dependent on ATP occupancy. We studied all substitutions at position 334 of the ATP site in Kir6.2ΔC26 that express in Xenopus oocytes. All substitutions disrupted ATP-dependent gating by 10-fold or more. Only positive-charged arginine or lysine at 334, however, slowed ligand-independent gating from the burst, and this was in some but not all patches. Moreover, the polycationic peptide protamine reversed the slowed gating from the burst of 334R mutant channels, and speeded the slow gating from the burst of wild-type SUR1/Kir6.2 in the absence of ATP. Our results support a two-step ligand-dependent linkage mechanism for Kir6.2 channels in which ATP-occupied sites function to electrostatically dissociate COOH-terminal domains from the membrane, then as in all Kir channels, free COOH-terminal domains and inner M2 helices transit to a lower energy state for gate closure.
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N.K, Noorudheen, and Shafi Ahmed. "A Prospective Analytical Study on Surgical Site Infections in a Tertiary Teaching Hospital." Journal of Evidence Based Medicine and Healthcare 7, no. 32 (August 10, 2020): 1591–95. http://dx.doi.org/10.18410/jebmh/2020/334.

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Hovinga, JK, J. Schaller, H. Stricker, WA Wuillemin, M. Furlan, and B. Lammle. "Coagulation factor XII Locarno: the functional defect is caused by the amino acid substitution Arg 353-->Pro leading to loss of a kallikrein cleavage site." Blood 84, no. 4 (August 15, 1994): 1173–81. http://dx.doi.org/10.1182/blood.v84.4.1173.1173.

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Abstract The dysfunctional coagulation factor XII (FXII) Locarno was purified from 2 L of the proposita's plasma. Studies to identify the molecular defect responsible for the lack of amidolytic and proteolytic activity of this FXII variant were performed. Amino acid sequence analysis of peptides obtained from FXII Locarno on activation with either trypsin or plasma kallikrein and dextran sulfate showed an amino acid substitution of Arg 353 by Pro. Thereby, the kallikrein cleavage site at Arg 353-Val 354 is lost. Although trypsin-activated FXII Locarno was fully cleaved at Arg 334-Asn 335 and at Arg 343-Leu 344, neither amidolytic nor proteolytic activity was generated. We conclude that proteolytic cleavage at Arg 343 in the absence of cleavage at Arg 353 is not sufficient to expose the enzymatic active site in FXII Locarno.
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Hovinga, JK, J. Schaller, H. Stricker, WA Wuillemin, M. Furlan, and B. Lammle. "Coagulation factor XII Locarno: the functional defect is caused by the amino acid substitution Arg 353-->Pro leading to loss of a kallikrein cleavage site." Blood 84, no. 4 (August 15, 1994): 1173–81. http://dx.doi.org/10.1182/blood.v84.4.1173.bloodjournal8441173.

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The dysfunctional coagulation factor XII (FXII) Locarno was purified from 2 L of the proposita's plasma. Studies to identify the molecular defect responsible for the lack of amidolytic and proteolytic activity of this FXII variant were performed. Amino acid sequence analysis of peptides obtained from FXII Locarno on activation with either trypsin or plasma kallikrein and dextran sulfate showed an amino acid substitution of Arg 353 by Pro. Thereby, the kallikrein cleavage site at Arg 353-Val 354 is lost. Although trypsin-activated FXII Locarno was fully cleaved at Arg 334-Asn 335 and at Arg 343-Leu 344, neither amidolytic nor proteolytic activity was generated. We conclude that proteolytic cleavage at Arg 343 in the absence of cleavage at Arg 353 is not sufficient to expose the enzymatic active site in FXII Locarno.
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Morris, Michael M. J., and Robert E. Lemon. "Mate choice in American Redstarts: by territory quality?" Canadian Journal of Zoology 66, no. 10 (October 1, 1988): 2255–61. http://dx.doi.org/10.1139/z88-334.

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We consider the hypothesis that mate choice in American Redstarts (Setophaga ruticilla) depends primarily on features of territories held by males. We test the hypothesis that the territories of yearling males are demonstrably different from and inferior for reproduction to those of adult males. Territories held by the two age-classes in New Brunswick, Canada, were floristically different, but there were also major differences in territorial features in three microgeographic areas, both within each age-group and without regard to age. There were greater differences in nest success between areas than between the age-classes. We detected no differences in immediate nest site features between nests built by the mates of yearling and adult males. There were differences across the three areas in the species of trees used as nest sites, probably reflecting differences in availability. Support for the claim of different reproductive success in relation to quality of territories held by the two age-classes of males is not convincing.
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Ventura, Marco, Carlos Canchaya, Valentina Bernini, Eric Altermann, Rodolphe Barrangou, Stephen McGrath, Marcus J. Claesson, et al. "Comparative Genomics and Transcriptional Analysis of Prophages Identified in the Genomes of Lactobacillus gasseri, Lactobacillus salivarius, and Lactobacillus casei." Applied and Environmental Microbiology 72, no. 5 (May 2006): 3130–46. http://dx.doi.org/10.1128/aem.72.5.3130-3146.2006.

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ABSTRACT Lactobacillus gasseri ATCC 33323, Lactobacillus salivarius subsp. salivarius UCC 118, and Lactobacillus casei ATCC 334 contain one (LgaI), four (Sal1, Sal2, Sal3, Sal4), and one (Lca1) distinguishable prophage sequences, respectively. Sequence analysis revealed that LgaI, Lca1, Sal1, and Sal2 prophages belong to the group of Sfi11-like pac site and cos site Siphoviridae, respectively. Phylogenetic investigation of these newly described prophage sequences revealed that they have not followed an evolutionary development similar to that of their bacterial hosts and that they show a high degree of diversity, even within a species. The attachment sites were determined for all these prophage elements; LgaI as well as Sal1 integrates in tRNA genes, while prophage Sal2 integrates in a predicted arginino-succinate lyase-encoding gene. In contrast, Lca1 and the Sal3 and Sal4 prophage remnants are integrated in noncoding regions in the L. casei ATCC 334 and L. salivarius UCC 118 genomes. Northern analysis showed that large parts of the prophage genomes are transcriptionally silent and that transcription is limited to genome segments located near the attachment site. Finally, pulsed-field gel electrophoresis followed by Southern blot hybridization with specific prophage probes indicates that these prophage sequences are narrowly distributed within lactobacilli.
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Baxter, Ian, Christopher Chippindale, Kate Fielden, Wayland Kennet, and Elizabeth Young. "Responses to Geoffrey Wainwright's report ‘The Stonehenge we deserve’, Antiquity 74 (2000): 334–42." Antiquity 74, no. 286 (December 2000): 944–51. http://dx.doi.org/10.1017/s0003598x00060567.

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In June this year, we published Geoffrey Wainwright's paper on ‘The Stonehenge we deserve'. This paper aimed to provide a review of progress towards sorting out the many problems of management, presentation and conservation of this World Heritage site and its landscape. As readers of ANTIQUITY are well aware, the fortunes of Stonehenge are intimately linked with politics, money and public opinion, and the long saga of possible solutions to make the site a better place for the future rest on these changing variables. Dr Wainwright outlined past strategies and the hope of future solutions as they were early this year. Already things have changed and the invited responses which we publish here discuss the recent changes of plan for Stonehenge. Baxter & Chippindale review the difficulties of the ‘current’ scheme and its incompatibility with visitor numbers. Fielden exposes the incompatibility of the A303 proposals for Stonehenge with legislation and planning; and Kennet & Young raise the problems of the various Plans and politics.We sent these responses to Dr Wainwright for his current view of the situation.
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Göbel, U. "334 Pediatric extracranial non-gonadal malignant germ cell tumors (EMGCT): Implication of site, age and dissemination." European Journal of Cancer Supplements 1, no. 5 (September 2003): S103. http://dx.doi.org/10.1016/s1359-6349(03)90367-3.

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Dissertations / Theses on the topic "Site 334"

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Dowdle, Daniel Mark. "The Internet as an Anchor: A Comparative Analysis Model of Internet Advocacy and Web Site Production in Japan and the Issue of History Textbook Reform." BYU ScholarsArchive, 2005. https://scholarsarchive.byu.edu/etd/334.

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This master's thesis is a grounded theory study of the development of the Internet as a tool for political action in Japan by groups and individuals producing web pages on the issue of history textbook reform. Through the analysis of 14 in-depth interviews, a framework is developed for understanding the role the Internet has taken in political action in Japan. As activists utilize the Internet in political activism, the Internet appears to be developing into an anchor for continuing political activism. For activists, the Internet is a central point of reference for both mass communication and interpersonal communication activities. The model indicates that the political alignment of an activist is an important factor in determining his or her preference for either interpersonal or mass communication on the Internet. Activists on the left tend to use the Internet as a tool for interpersonal communication and coordination, while activists on the right tend to view the Internet as a tool for mass persuasion. The model of Internet activism developed in the thesis is also compared with models of communication derived from theories of technological determinism and social shaping of technologies. Consistent with technological determinist ideas, the Japanese case demonstrates that as activists rely on the Internet, other media show signs of becoming content for the new medium. However, the Japanese case also shows that pre-existing needs and the political framework of an activist have a strong shaping effect on Internet use, indicating the importance of a social shaping of technologies approach.
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Monjanel, Anne-Lise. "Les diatomées oligocènes à holocènes de l'Atlantique Nord et de la Méditerranée occidentale : biostratigraphie et paléoceanographie." Brest, 1987. http://www.theses.fr/1987BRES2035.

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Etude de la flore des diatomees de forages oceaniques et de coupes situees a terre: site 647 de l'odp pour l'oligocene; formation des moronites et coupes de cobatillas en espagne, coupes de saint-laurent la vernede et d'uzes dans le gard, coupes du "tripoli di contignaco" en italie et forages dsdp des sites 116, 334, 335 et 545 pour le miocene; site 646 de l'odp pour le plio-pleistocene. L'interpretation biostratigraphique permet de mettre en evidence des hiatus de la sedimentation ,lies a la circulation oceanique profonde et a la presence d'upwellings cotiers
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Giachini, Lisa <1978&gt. "Structure and dynamics of metal sites in proteins: X-ray Absorption Spectroscopy investigations." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/334/.

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Sun, Xixi. "Scaffolding Catalysis: Towards Regioselective Hydroformylation of Alkenes and Site-Selective Functionalization of Polyhydroxylated Molecules." Thesis, Boston College, 2013. http://hdl.handle.net/2345/3324.

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Thesis advisor: Kian L. Tan
Chapter 1. We reported the first synthesis of all-carbon quaternary centers via hydroformylations using a catalytic directing group. With the ability of reversibly and covalently binding to a substrate, and coordinating to a metal center, scaffolding catalyst 1.1 is able to direct the branch-selective hydroformylation of 1,1-disubstituted olefins under mild temperature. Chapter 2. We have designed and synthesized a chiral organocatalyst 2.11. This catalyst is able to covalently bind to one hydroxyl, and utilize the induced intramolecularity to stereoselectively functionalize the other hydroxyl within a cis-1,2-diol via electrophile transfer. Catalyst 2.11 was used in the desymmetrization of meso-1,2-diols under mild conditions (4 C to room temperature), leading to high yields and selectivities for a broad substrate scope. Chapter 3. Catalyst 3.1 and 3.6 were demonstrated to selectively bind to primary hydroxyls over secondary hydroxyls. By combining the binding selectivity with asymmetric catalysis, these scaffolding catalysts were shown to promote the selective silylation of secondary hydroxyls within terminal (S)-1,2-diols. The reversal of substrate bias was further applied to a regiodivergent kinetic resolution of racemic terminal 1,2-diols, producing secondary protected products in synthetically practical levels of enantioselectivity (>95:5 er) and yields (≥40%). Time course studies of this reaction further revealed the optimal condition to form the primary silylated product in high s-factor. Chapter 4. Based on the previous understanding of catalyst 4.5 and 4.6, the exclusive catalyst recognition of cis-1,2-diols within polyhydroxylated molecules was further discovered. This unique functional group display recognition was further allied with the catalyst's ability to stereoselectively differentiate hydroxyls within cis-1,2-diols, enabling the site-selective protection, functionalization, and activation of the inherently less reactive axial hydroxyl groups within carbohydrates. This methodology also enables the selective functionalization of multiple complex molecules, including digoxin, mupirocin, and ribonucleosides, demonstrating the potential power of scaffolding catalysis in the rapid access to valuable synthetic derivatives of polyhydroxylated compounds
Thesis (PhD) — Boston College, 2013
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Chemistry
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Oberg, Danielle. "Fossil Moles from the Gray Fossil Site, TN: Implications for Diversification and Evolution of North American Talpidae." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etd/3394.

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The Gray Fossil Site (GFS) is one of the richest Cenozoic terrestrial localities in the eastern United States. This study describes the first talpid specimens recovered from the GFS. Using measurements and comparisons of dental and humerus morphology, I identify 4 talpids (Parascalops nov. sp., Quyania cf. Q. europaea, Mioscalops (= Scalopoides) sp., and an unidentified stem desman) occurring at the GFS. Humeral morphology has been used to diagnose talpid species and study relationships. A geometric morphometric analysis showed that humerus shape is highly reflective of locomotor ecology in extant talpids and allows ecological inferences for fossil talpids. Hierarchical cluster analysis using morphometric data allowed examination of similarity among taxa and helped to secondarily verify taxonomic designations for the GFS taxa. The resulting phenogram showed strong similarity to the most up-to-date molecular cladogram and actually matched phylogenetic relationships substantially better than any morphological cladistic analyses to date.
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Hildum, Brendan. "Arsenic Speciation and Groundwater Chemistry at a Landfill Site: A Case Study of Shepley's Hill Landfill." Thesis, Boston College, 2013. http://hdl.handle.net/2345/3234.

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Thesis advisor: Rudolph Hon
A groundwater plume beneath a capped landfill in north-central Massachusetts contains dissolved arsenic concentrations exceeding 10,000 ppb at several locations. The landfill closed in the early 1990's and contains minimally documented solid waste materials deposited over the course of nearly a century. The source(s), fate, and transport of arsenic in the landfill aquifer have been studied extensively over the past decade; however, the source and pathways of arsenic are not yet fully defined. The primary source of arsenic likely involves a combination of the landfill waste material, the peat, the underlying overburden sequence, and/or bedrock minerals. Arsenic mobilization is most likely assisted by reducing conditions created by the decomposition of organic materials within the landfill and underlying peat present prior to the initiation of waste disposal. Another possibility is an arsenic-bearing groundwater discharging from the underlying bedrock from the oxidation of naturally occurring sulfides. Aqueous arsenic species, including inorganic arsenite [As(III), As(OH)3] and arsenate [As(V), AsO(OH)3], and organic monomethylarsonic acid [MMA(V), CH3AsO(OH)2] and dimethylarsinic acid [DMA(V), (CH3)2AsO(OH)], provide information as to where the arsenic is primarily originating from and how it is transported through the aquifer. Furthermore, the analysis of major ions, metals, and groundwater parameters from different zones of the landfill with varying arsenic concentrations will aid in the delineation of probable arsenic sources, the mobilization processes, and arsenic transport modes within the aquifer. A more complete conceptual site model with respect to arsenic speciation and groundwater chemistry will lead to a better understanding of geochemical processes within and beneath the landfill waste pile and also assist with future remediation of the aquifer. Using arsenic speciation and groundwater chemistry data, it was determined that although all four potential arsenic sources likely contribute to the total arsenic concentrations, the overall contribution from the landfill material, peat layer, and bedrock is minimal relative to the iron-oxyhydroxides coated on the sands particles throughout the aquifer which acts as the primary arsenic source. Oxidation-reduction potential and dissolved oxygen are the controlling factors in relation to mobilization and transport of arsenic species from aquifer features and an understanding of these processes at the local level can be further applied to global-scale arsenic contamination
Thesis (MS) — Boston College, 2013
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Geology and Geophysics
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Scutelnicu, Gina. "Community Development Districts: The Entrepreneurial Side of Government." FIU Digital Commons, 2010. http://digitalcommons.fiu.edu/etd/314.

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In an effort to reduce the cost and size of government public service delivery has become more decentralized, flexible and responsive. Public entrepreneurship entailed, among other things, the establishment of special-purpose governments to finance public services and carry out development projects. Community Development Districts (CDDs) are a type of special-purpose governments whose purpose is to manage and finance infrastructure improvements in the State of Florida. They have important implications for the way both growth management and service delivery occur in the United States. This study examined the role of CDDs for growth management policy and service delivery by analyzing the CDD profile and activity, the contribution of CDDs to the growth management and infrastructure development as well as the way CDD perceived pluses and minuses impact service delivery. The study used a mixed methods research approach, drawing on secondary data pertaining to CDD features and activity, semi-structured interviews with CDD representatives and public officials as well as on a survey of public officials within the counties and cities that have established CDDs. Findings indicated that the CDD institutional model is both a policy and a service delivery tool for infrastructure provision that can be adopted by states across the United States. Results showed that CDDs inhibit rather than foster growth management through their location choices, type and pattern of development. CDDs contributed to the infrastructure development in Florida by providing basic infrastructure services for the development they supported and by building and dedicating facilities to general-purpose governments. Districts were found to be both funding mechanisms and management tools for infrastructure services. The study also pointed to the fact that specialized governance is more responsive and more flexible but less effective than general-purpose governance when delivering services. CDDs were perceived as being favorable for developers and residents and not as favorable for general-purpose governments. Overall results indicated that the CDD is a flexible institutional mechanism for infrastructure delivery which has both advantages and disadvantages. Decision-makers should balance districts’ institutional flexibility with their unintended consequences for growth management when considering urban public policies.
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Bentolila, Jacques. "Secondary School Inclusion Rates: The Relationship Between the Training and Beliefs of School Site Principals and the Implementation of Inclusion." FIU Digital Commons, 2010. http://digitalcommons.fiu.edu/etd/324.

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Programs require strong support and guidance from those in leadership positions to ensure proper implementation (Fullen, 2001). Consequently, school site principals must rely on the training they have received to support them in making appropriate decisions. It is the school site principal’s leadership that is pivotal in the success of students with disabilities (DiPaola & Walther-Thomas, 2003; Monteith, 2000). In fact, the principal has a moral obligation to provide an environment that supports social justice in schools (Grogan & Andrews, 2002). The inclusion of students with disabilities does just that—it ensures that these students are not segregated to a “separate but equal” education. This study utilized a participant survey to collect data on principals’ beliefs and training in special education. This information was compared to the percentage of time students with disabilities spent with their non-disabled peers in the principals’ respective schools. An analysis was conducted to identify if a linear relationship exists between the selected variables and the inclusion percentages. Open-ended questions were included in the original survey which allowed for a thematic analysis of the responses. These responses were utilized to allow participants to further express their thoughts on the identified variables. Results indicated that there were no statistically significant relationships identified between the beliefs and training of secondary school site principals and the percentage of time that their students in special education spend with their non-disabled peers. Although the original research questions were not supported, further post hoc analysis indicated that the results obtained did support that the principals believed inclusion had a social benefit to students. Additional investigation into the academic benefits of inclusion is still needed. In addition, principals who indicated that they had some type of training in special education indicated a higher percentage that the individual student should be the focal point when making placement decisions. These results support the need for further research in the area of principal preparation programs and their relationships to the daily practice of school site principals.
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Ennehdi, Atef. "Étude du réseau d'interactions tertiaires au sein du site catalytique du ribozyme delta par méthode de SELEX." Mémoire, Université de Sherbrooke, 2004. http://savoirs.usherbrooke.ca/handle/11143/3349.

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Le virus de l'hépatite delta humaine (VHD) est un pathogène infectieux qui est associé à une hépatite fulminante chez l'humain. Ce virus possède un génome circulaire d'ARN simple brin comportant deux régions auto-catalytiques (ribozymes). Ce présent travail a pour but d'étudier le mécanisme moléculaire ainsi que le sentier de repliement tridimensionnel subit par ce ribozyme au cours de l'événement de coupure. Afin d'atteindre ce but, nous allons identifier toutes les interactions incluant les bases des ribonucléotides composant le coeur catalytique de ce ribozyme. Pour ce faire, nous utiliserons l'approche de sélection in vitro (SELEX). Malgré son utilisation commune pour l'étude du ribozyme delta , l'approche de SELEX n'a jamais donné de résultats concluants au sujet de la tectonique de ce ribozyme pendant l'événement de coupure. Ceci est dû au fait que dans toutes les analyses précédentes, le site catalytique de ce ribozyme n'a jamais été totalement dégénéré. Par conséquent, nous avons développé une stratégie de SELEX unique qui nous permettra éventuellement de dégénérer tous les nucléotides du site catalytique et de sélectionner tous les ribozymes actifs existant dans une banque combinatoire."--Résumé abrégé par UMI.
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Zhang, Liye. "Carrying capacity assessment of diving sites in Hong Kong and Malaysia." HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/339.

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This study aims to understand tourism carrying capacities of diving sites in Hong Kong and Malaysia. Specifically, ecological, psychological and social carrying capacities were assessed. Methodology involved photo quadrat transect survey, questionnaire survey and visual experiment survey. Over a period of two calendar years (2013 and 2014), 13, 12 and 9 photo quadrat transect surveys were conducted in Sharp Island, Tsim Chau and Mabul Island (Ray Point and Eel Garden) respectively to provide data for ecological carrying capacity assessment. In addition, 455 and 342 questionnaires were collected in Hong Kong and Mabul Island respectively to assess divers' satisfaction with diving attributes of the respective dive sites. Regarding social carrying capacity assessment, 247 and 158 visual experiment questionnaires were collected to assess crowding as perceived by divers in the two sites.;The ecological carrying capacity of Sharp Island lies between 172 and (less than) 825 divers every quarter in the absence of better solutions. At Tsim Chau, diving activity is not the most important factor in influencing the coverage of sea anemone. In addition, the use of additional (subjective) data was necessary to define the ecological carrying capacity of Tsim Chau and possibly Sharp Island. In Mabul Island, the results show that the ecological carrying capacity is about 16800-17200 divers per year at Ray Point and about 15600-16800 divers per year at Eel Garden. Based on the findings, it is likely that the usage of the diving sites on Sharp Island, Ray Point and Eel Garden have already exceeded the social carrying capacity. Regarding the psychological carrying capacity, this study found that the most important factor that influences divers' willingness to return to Hong Kong diving sites is "the quality of corals". In Mabul Island, the most important factor is "the value for money of Mabul diving". However, no studied diving sites have exceeded their psychological carrying capacities. Regarding the social carrying capacity, on both Hong Kong and Mabul Island diving sites, the "number of divers" was found to be the most influential factor for divers' perceived crowding. In Hong Kong, divers' begin to feel unacceptably crowded if 78̃ divers are visible to them at one time whereas in Mabul Island, divers would start to feel unacceptably crowded if 8 to 9 divers were visible to them at one time. Based on this, it is likely that the usage of both Hong Kong and Mabul Island diving sites have already exceeded the social carrying capacity.;With the increasing popularity of diving in recent years, divers and diving trips operators around the world need to be aware of divers' impact on coral reef, divers' satisfaction and underwater crowding problem. Finally, a series of management and policy measures to minimise the impact of diving activity on coral, improve divers' satisfaction and mitigate divers' crowding perception in underwater environment are proposed for sustainable use of diving sites in Hong Kong and Mabul Island.
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Books on the topic "Site 334"

1

New Jersey. Legislature. Senate. Committee on Energy and Environment. Public hearing before Senate Energy and Environment Committee: Senate bills 899, 1462, 2011, 2012, and Senate concurrent resolutions 73, 82 (hazardous discharge site cleanup financing) : April 28, 1986, room 334, State House Annex, Trenton, New Jersey. Trenton, N.J: The Committee, 1986.

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Committee, New Jersey Legislature General Assembly Environmental Quality. Public meeting before Assembly Environmental Quality Committee: Status of civilian and military cleanup of hazardous discharge sites : June 25, 1987, Room 334, State House Annex, Trenton, New Jersey. Trenton, N.J: The Committee, 1987.

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United States. Congress. Senate. Committee on Energy and Natural Resources. Trails Interpretation Center, Council Bluffs, Iowa: Report (to accompany S. 338). [Washington, D.C.?: U.S. G.P.O., 1989.

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Miner, James J. Plainfield potential wetland compensation site: Final hydrogeologic characterization report : Illinois Route 59, near Plainfield, Will County, Illinois (Federal Aid Project 338). [Champaign, Ill.]: Illinois State Geological Survey, 1997.

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Thorium reimbursement: Report (to accompany H.R. 3343) (including cost estimate of the Congressional Budget Office.). [Washington, D.C: U.S. G.P.O., 2001.

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Saxby, David. The Watch House, St Mary Magdalen Churchyard, Bermondsey Square, London SE16, London Borough of Southwark: TQ:333 793 County Scheduled Ancient Monument Number: SAM 165 Site Code: BNY98. London: Museum of London Archaeological Service, 1998.

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Vogelsang-Rempe, Barbara. Umweltstrafrechtliche Relevanz der Altlasten: Eine Untersuchung zu der Frage, ob im Zusammenhang mit Altlasten, die vor dem 1.7.1980 entstanden sind, die Tatbestände der [Paragraphen] 326, 324 StGB rechtswidrig verwirklicht werden. Bochum: N. Brockmeyer, 1992.

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United States. Congress. Senate. Committee on Energy and Natural Resources. Subcommittee on National Parks. Miscellaneous parks bills: Hearing before the Subcommittee on National Parks of the Committee on Energy and Natural Resources, United States Senate, One Hundred Ninth Congress, first session, on S. 242, S. 262, S. 336, S. 670, S. 777, H.R. 126, April 28, 2005. Washington: U.S. G.P.O., 2005.

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Victor, Levy Joseph, ed. Pharmacology and abuse of cocaine, amphetamines, ecstasy and related designer drugs: A comprehensive review on their mode of action, treatment of abuse and intoxication. Dordrecht: Springer, 2009.

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Ney-Grimm, Jessica, S. Arensberg, and Steven J. Arensberg. MECCG Sites and Scenarios (#3343). Iron Crown Enterprises, 1997.

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Book chapters on the topic "Site 334"

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Moody, Amie D., James P. Robblee, and David L. Bain. "Dissecting the Linkage Between Transcription Factor Self-Assembly and Site-Specific DNA Binding: The Role of the Analytical Ultracentrifuge." In Methods in Molecular Biology, 187–204. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-61779-334-9_10.

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Rouhani, Shahrokh, and Roozbeh Kangari. "Landfill Site Selection." In Expert Systems: Applications to Urban Planning, 159–69. New York, NY: Springer New York, 1990. http://dx.doi.org/10.1007/978-1-4612-3348-0_10.

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Ming, Dengming, and Michael E. Wall. "Predicting Binding Sites by Analyzing Allosteric Effects." In Methods in Molecular Biology, 423–36. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-61779-334-9_23.

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Deng, Yang, and Aiqun Li. "Bridge-Site Extreme Wind Prediction." In Structural Health Monitoring for Suspension Bridges, 27–43. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-3347-7_2.

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Duggan, Kelsey C., Joel Musee, and Lawrence J. Marnett. "Peroxidase Active Site Activity Assay." In Methods in Molecular Biology, 55–65. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-59745-364-6_6.

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Stemkoski, Lee. "Side-Scrolling Games." In Java Game Development with LibGDX, 173–87. Berkeley, CA: Apress, 2018. http://dx.doi.org/10.1007/978-1-4842-3324-5_7.

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Mokhtar, Ernieza Suhana, Wan Nur Azliena Wan Mohd Zaki, Noraini Nasirun, Fatin Amirah Hanif, and Idham Nugraha. "Geospatial Site Suitability for Sustainable Property Investment." In Charting the Sustainable Future of ASEAN in Science and Technology, 49–64. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-3434-8_5.

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Findikaki, Irene. "SISES: An Expert System for Site Selection." In Expert Systems: Applications to Urban Planning, 125–32. New York, NY: Springer New York, 1990. http://dx.doi.org/10.1007/978-1-4612-3348-0_7.

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Grossoehme, Nicholas E., and David P. Giedroc. "Allosteric Coupling Between Transition Metal-Binding Sites in Homooligomeric Metal Sensor Proteins." In Methods in Molecular Biology, 31–51. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-61779-334-9_3.

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Rempt, R. D. "Active Corrosion Site Detection Scheme Using Optical Fibers." In Review of Progress in Quantitative Nondestructive Evaluation, 1175–81. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3344-3_152.

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Conference papers on the topic "Site 334"

1

Shmirina, Maria. "Tamgas on bone products of sity-site Anushkar." In Actual Archaeology 5. Institute for the History of Material Culture Russian Academy of Sciences, 2020. http://dx.doi.org/10.31600/978-5-907298-04-0-2020-351-354.

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Kaufman, Randal J., Debra D. Pittman, Louise C. Wasley, W. Barry Foster, Godfrey W. Amphlett, and Alan R. Giles. "DIRECTED MUTAGENESIS IN THE STUDY OF THE REQUIREMENTS FOR FACTOR VIII ACTIVITY IN VITRO AND IN VIVO." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644769.

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Factor VIII is a high molecular weight plasma glycoprotein that functions in the blood clotting cascade as the cofactor for factor DCa proteolytic activation of factor X. Factor VIII does not function proteolytically in this reaction hut itself can be proteolytically activated by other coagulation enzymes such as factor Xa and thrombin. In the plasma, factor VIII exists as a 200 kDa amino-terminal fragment in a metal ion stabilized complex with a 76 kDa carboxy-terminal fragment. The isolation of the cENA for human factor VIII provided the deduced primary amino acid sequence of factor VIIT and revealed three distinct structural domains: 1) a triplicated A domain of 330 amino acids which has homology to ceruloplasmin, a plasma copper binding protein, 2) a duplicated C domain of 150 amino acids, and 3) a unique B domain of 980 amino acids. These domains are arranged as shown below. We have previously reported the B domain is dispensible far cofactor activity in vitro (Toole et al. 1986 Proc. Natl. Acad 5939). The in vivo efficacy of factor VIII molecules harboring the B domain deletion was tested by purification of the wildtype and modified forms and infusion into factor VIII deficient, hemophilic, dogs. The wildtype and the deleted forms of recombinant derived factor VIII exhibited very similar survival curves (Tl/2 = 13 hrs) and the cuticle bleeding times suggested that both preparations appeared functionally equivalent. Sepharose 4B chromatography indicated that both factor VIII molecules were capable of binding canine plasma vWF.Further studies have addressed what cleavages are necessary for activation of factor VIII. The position of the thrombin, factor Xa, and activated protein C (AFC) cleavage sites within factor VIII are presented below, site-directed ENA medicated mutagenesis has been performed to modify the arginine at the amino side of each cleavagesite to an soleucine. In all cases this modification resulted in molecules that were resistant to cleavage by thrombin at the modified site. Modification of the thrombin cleavage sites at 336 and 740 and modification of the factor Xa cleavage site at 1721 resulted in no loss of cofactor activity. Modification of the thrombin cleavage site at either 372 or 1689 destroyed oofactor activity. Modification of the thrombin cleavage site at 336 resulted in a factor VIII having an increased activity, possibly due to resistance to inactivation. These results suggest the requirement of cleavage at residues 372 and 1689 for cofactor activity.
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Niehoff, James W. "Downtown Redevelopment with Complex Site Constraints." In Biennial Geotechnical Conference 2008. Reston, VA: American Society of Civil Engineers, 2008. http://dx.doi.org/10.1061/41006(332)1.

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Yun, GunJin, Jamshid Ghaboussi, and Youssef Hashash. "Predictor-Corrector Algorithm for Multi-Site Hybrid Simulation." In Structures Congress 2008. Reston, VA: American Society of Civil Engineers, 2008. http://dx.doi.org/10.1061/41016(314)255.

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HARDY, TERRY, and MARGARET WHALEN. "Slush hydrogen transfer studies at the NASA K-Site Test Facility." In 28th Joint Propulsion Conference and Exhibit. Reston, Virigina: American Institute of Aeronautics and Astronautics, 1992. http://dx.doi.org/10.2514/6.1992-3384.

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Smith, Terry, and Richard Spiers. "Perceptions of E-commerce Web Sites Across Two Generations." In InSITE 2009: Informing Science + IT Education Conference. Informing Science Institute, 2009. http://dx.doi.org/10.28945/3334.

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Numerous studies have examined and predicted the usage of e-commerce Web sites using the Technology Acceptance Model and its primary constructs of perceived usefulness and perceived ease of use. Smith (2008) conducted an empirical study of four e-commerce Web sites with participation from a unique and often understudied segment of the population - the senior generation. In addition, he called for additional research on the same e-commerce Web sites with participants from today's student population, a generation that has grown up with computers and the Internet. During the Spring 2008 semester, the authors duplicated Smith's research and conducted a field experiment with a purposeful sample of students enrolled in four courses in the School of Information Technology at Macon State College. Consistent with the conclusion by Smith, of significant worth is the test of the robustness of the Technology Acceptance Model (TAM) when applied to e-commerce adoption by both the senior generation and the net generation. The model’s predictive and explanatory capabilities still hold true. This is the only study we know of that compares two generations and their perceptions of e-commerce Web sites.
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Michaud, B., and J. Gumtow. "Hydrologic Analysis for a Floodplain Forest Wetland Mitigation Site." In World Environmental and Water Resources Congress 2006. Reston, VA: American Society of Civil Engineers, 2006. http://dx.doi.org/10.1061/40856(200)337.

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Payment, C. L., and D. W. Watkins, Jr. "Hydrologic Information System for Greenfield Site Development and Management." In World Environmental and Water Resources Congress 2007. Reston, VA: American Society of Civil Engineers, 2007. http://dx.doi.org/10.1061/40927(243)324.

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Quiring, S. J., and J. Tsuji. "335. Using Risk Assessment to Evaluate Health Risks During Redevelopment of a Smelter Site." In AIHce 1998. AIHA, 1999. http://dx.doi.org/10.3320/1.2762735.

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Leicht, Robert M., and John I. Messner. "Improving Site Utilization Planning through the Use of Interactive Workspaces." In Construction Research Congress 2009. Reston, VA: American Society of Civil Engineers, 2009. http://dx.doi.org/10.1061/41020(339)45.

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Reports on the topic "Site 334"

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Overbay, Larry, Boutin Jr., Archiable Matthew, McClung Robert, Robitaille Christina, and George. Standardized UXO Technology Demonstration Site: Open Field Scoring Record No. 364. Fort Belvoir, VA: Defense Technical Information Center, May 2005. http://dx.doi.org/10.21236/ada435577.

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Overbay, Larry, Archiable Jr., McClung Robert, and Christina. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 354. Fort Belvoir, VA: Defense Technical Information Center, January 2005. http://dx.doi.org/10.21236/ada432657.

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T. M. Fitzmaurice. Closure Report for Housekeeping Category Corrective Action Unit 343: Areas 1, 3, & 4 Housekeeping Sites, Nevada Test Site, Nevada. Office of Scientific and Technical Information (OSTI), February 2000. http://dx.doi.org/10.2172/799769.

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J. M. Capron. Remaining Sites Verification Package for the 331 Life Sciences Laboratory Drain Field Septic System, Waste Site Reclassification Form 2008-020. Office of Scientific and Technical Information (OSTI), October 2008. http://dx.doi.org/10.2172/944167.

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A. T. Urbon. Closure Report for Corrective Action Unit 330: Areas 6, 22, and 23 Tanks and Spill Sites, Nevada Test Site, Nevada. Office of Scientific and Technical Information (OSTI), July 2003. http://dx.doi.org/10.2172/815138.

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K. K. Knapp. Post-Closure Inspection Report for Corrective Action Unit 333: U-3auS Disposal Site Annual Report, Nevada Test Site, Nevada. Office of Scientific and Technical Information (OSTI), September 2003. http://dx.doi.org/10.2172/815200.

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J. L. Traynor. U-3auS Disposal Site Corrective Action Unit 333 Post-Closure Inspection Annual Report. Office of Scientific and Technical Information (OSTI), September 2002. http://dx.doi.org/10.2172/807449.

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T. M. Fitzmaurice. Streamlined Approach for Environmental Restoration Plan for Corrective Action Unit 330: Areas 6, 22, and 23 Tanks and Spill Sites, Nevada Test Site, Nevada. Office of Scientific and Technical Information (OSTI), August 2001. http://dx.doi.org/10.2172/794081.

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Lynn Kidman. Addendum to the Closure Report for Corrective Action Unit 394: Areas 12, 18, and 29 Spill/Release Sites Nevada Test Site, Nevada, Revision 0. Office of Scientific and Technical Information (OSTI), October 2008. http://dx.doi.org/10.2172/945279.

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Shannon Parsons. Addendum to Closure Report for Housekeeping Category Corrective Action Unit 354 Nevada Test Site, Nevada. Office of Scientific and Technical Information (OSTI), May 1999. http://dx.doi.org/10.2172/750419.

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