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Journal articles on the topic 'Site-specific primary data'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Grzebisz, Witold. "Site-Specific Nutrient Management." Agronomy 11, no. 4 (2021): 752. http://dx.doi.org/10.3390/agronomy11040752.

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The editorial introduces to a Special Issue entitled ”Site-Specific Nutrient Management. The concept of the nitrogen gap (NG) is as a core challenge for an effective realization of the so called “twin objectives” in sustainable agriculture. This special issue stresses on some hot spots in crop production, being responsible in the yield gap development, that farmers have to take control. The yield gap cannot be ameliorated without the synchronization of the in-season requirements of the currently grown crop for N with its three-dimensional variability in a supply on a field (temporal, spatial a

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Zhao, Xiaoyi, Vitali Fioletov, Alberto Redondas, et al. "The site-specific primary calibration conditions for the Brewer spectrophotometer." Atmospheric Measurement Techniques 16, no. 8 (2023): 2273–95. http://dx.doi.org/10.5194/amt-16-2273-2023.

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Abstract. The Brewer ozone spectrophotometer (the Brewer) is one of the World Meteorological Organization (WMO) Global Atmosphere Watch (GAW)'s standard ozone-monitoring instruments since the 1980s. The entire global Brewer ozone-monitoring network is operated and maintained via a hierarchical calibration chain, which started from world reference instruments that are independently calibrated via the primary calibration method (PCM) at a premium site (National Oceanic and Atmospheric Administration's (NOAA) Mauna Loa Observatory, Hawaii). These world reference instruments have been maintained b

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Pearson, Clare, Veronique Poirier, Karen Fitzgerald, Greg Rubin, and Willie Hamilton. "Cross-sectional study using primary care and cancer registration data to investigate patients with cancer presenting with non-specific symptoms." BMJ Open 10, no. 1 (2020): e033008. http://dx.doi.org/10.1136/bmjopen-2019-033008.

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IntroductionPatients presenting to primary care with site-specific alarm symptoms can be referred onto urgent suspected cancer pathways, whereas those with non-specific symptoms currently have no dedicated referral routes leading to delays in cancer diagnosis and poorer outcomes. Pilot Multidisciplinary Diagnostic Centres (MDCs) provide a referral route for such patients in England.ObjectivesThis work aimed to use linked primary care and cancer registration data to describe diagnostic pathways for patients similar to those being referred into MDCs and compare them to patients presenting with m

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Molnar, Sheri, Stan E. Dosso, and John F. Cassidy. "Uncertainty of linear earthquake site amplification via Bayesian inversion of surface seismic data." GEOPHYSICS 78, no. 3 (2013): WB37—WB48. http://dx.doi.org/10.1190/geo2012-0345.1.

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We examine uncertainty in predicted linear 1D site amplification due to uncertainty in shear-wave velocity ([Formula: see text]) structure quantified from Bayesian (probabilistic) inversion of microtremor array dispersion data. Based on a sample of [Formula: see text] profiles drawn from the posterior probability density of the microtremor inversion, probability distributions are computed for common predictors of site amplification including [Formula: see text] (traveltime average [Formula: see text] to a depth [Formula: see text]) and amplification spectra based on seismic impedance variation

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Raza, Shaan M., Paul W. Gidley, Michael E. Kupferman, Ehab Y. Hanna, Shirley Y. Su, and Franco DeMonte. "Site-Specific Considerations in the Surgical Management of Skull Base Chondrosarcomas." Operative Neurosurgery 14, no. 6 (2017): 611–19. http://dx.doi.org/10.1093/ons/opx171.

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Abstract BACKGROUND Numerous approaches have been reported in the management of skull base chondrosarcomas. Data are lacking for surgical outcomes by the tumor site of origin. OBJECTIVE To provide insight into outcomes by site of origin and factors affecting resection in order to aid in surgical approach selection. METHODS A retrospective review was conducted of 49 patients with chondrosarcoma treated at our institution. Charts were reviewed for tumor- and treatment-related factors. Extent of resection was the primary outcome, while neurological function and surgical complications were seconda

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Borkowski, Andrzej Szymon, Anna Bielska, and Jolanta Kwiatkowska-Malina. "Site-specific efficient management of soil resources using GIS and BIM technologies." Reports on Geodesy and Geoinformatics 117, no. 1 (2024): 89–98. http://dx.doi.org/10.2478/rgg-2024-0009.

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Abstract The spatial data sets of soil resources are essential for the interpretation of the site-specific ecosystems, not only concerning process investigations, but also for sustainable soil management The objective of the study was to attempt identification of the primary parameters influencing the rational management of soils available without the necessity of carrying out time-consuming and costly field and laboratory research. The research was carried out in the Pawłów commune (north-eastern part of the Świętokrzyskie Voivodeship, Poland). The research included the application of differe

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Shashni, Rajesh, M. Zuhaib Qayyum, V. Vishalini, Debashish Dey, and Ranjan Sen. "Redundancy of primary RNA-binding functions of the bacterial transcription terminator Rho." Nucleic Acids Research 42, no. 15 (2014): 9677–90. http://dx.doi.org/10.1093/nar/gku690.

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Abstract The bacterial transcription terminator, Rho, terminates transcription at half of the operons. According to the classical model derived from in vitro assays on a few terminators, Rho is recruited to the transcription elongation complex (EC) by recognizing specific sites (rut) on the nascent RNA. Here, we explored the mode of in vivo recruitment process of Rho. We show that sequence specific recognition of the rut site, in majority of the Rho-dependent terminators, can be compromised to a great extent without seriously affecting the genome-wide termination function as well as the viabil

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Mizukami, Takuro, Masaki Takahashi, Yu Sunakawa, et al. "Identification of site-specific genome alterations in metastatic colorectal cancer: Sub-study 003 of the SCRUM-Japan GI-SCREEN." Journal of Clinical Oncology 37, no. 4_suppl (2019): 578. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.578.

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578 Background: Primary tumor sidedness is known to be an independent prognostic factor and a predictor for the efficacy of anti-EGFR antibody. However, limited information is available regarding the role of primary tumor site for the treatment of metastatic colorectal cancer (mCRC) patients (pts), including gene mutation profiles, prognosis, and prediction for treatment. This study was conducted as a sub-study of the SCRUM-Japan GI-SCREEN, the Nationwide Cancer Genome Screening Project in Japan. Methods: Among participants of the GI-Screen 2013-01-CRC, untreated pts with mCRC which samples we

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Samaržija, Ivana. "Site-Specific and Common Prostate Cancer Metastasis Genes as Suggested by Meta-Analysis of Gene Expression Data." Life 11, no. 7 (2021): 636. http://dx.doi.org/10.3390/life11070636.

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Anticancer therapies mainly target primary tumor growth and little attention is given to the events driving metastasis formation. Metastatic prostate cancer, in comparison to localized disease, has a much worse prognosis. In the work presented here, groups of genes that are common to prostate cancer metastatic cells from bones, lymph nodes, and liver and those that are site-specific were delineated. The purpose of the study was to dissect potential markers and targets of anticancer therapies considering the common characteristics and differences in transcriptional programs of metastatic cells

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Li, Yinghua, Danna Xie, Xiaojing Chen, Teng Hu, Simin Lu, and Yunwei Han. "Prognostic Value of the Site of Distant Metastasis and Surgical Interventions in Metastatic Gastric Cancer: A Population-Based Study." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303382096413. http://dx.doi.org/10.1177/1533033820964131.

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Background: Studies on the prognostic significance of site-specific distant metastasis, multiple-site metastases, and the impact of surgery of the primary tumor and metastatic lesion on survival outcomes of patients with metastatic gastric cancer (GC) remain elusive. Therefore, this study aimed to investigate the prognostic significance of the site of distant metastasis among patients with metastatic GC. Furthermore, the effect of surgery of the primary tumor and metastatic lesion on the prognosis of metastatic GC was also analyzed. Methods: The data of 4,221 eligible patients, who were diagno

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Minunno, F., M. Peltoniemi, S. Launiainen, et al. "A simplified gross primary production and evapotranspiration model for boreal coniferous forests – is a generic calibration sufficient?" Geoscientific Model Development Discussions 8, no. 7 (2015): 5089–137. http://dx.doi.org/10.5194/gmdd-8-5089-2015.

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Abstract. The problem of model complexity has been lively debated in environmental sciences as well as in the forest modelling community. Simple models are less input demanding and their calibration involves a lower number of parameters, but they might be suitable only at local scale. In this work we calibrated a simplified ecosystem process model (PRELES) to data from multiple sites and we tested if PRELES can be used at regional scale to estimate the carbon and water fluxes of Boreal conifer forests. We compared a multi-site (M-S) with site-specific (S-S) calibrations. Model calibrations and

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Wanner, Miriam, Katarina L. Matthes, Dimitri Korol, Silvia Dehler, and Sabine Rohrmann. "Indicators of Data Quality at the Cancer Registry Zurich and Zug in Switzerland." BioMed Research International 2018 (June 13, 2018): 1–11. http://dx.doi.org/10.1155/2018/7656197.

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Data quality is an important issue in cancer registration. This paper provides a comprehensive overview of the four main data quality indicators (comparability, validity, timeliness, and completeness) for the Cancer Registry Zurich and Zug (Switzerland). We extracted all malignant cancer cases (excluding non-melanoma skin cancer) diagnosed between 1980 and 2014 in the canton of Zurich. Methods included the proportion of morphologically verified cases (MV%), the proportion of DCN and DCO cases (2009–2014), cases with primary site uncertain (PSU%), the stability of incidence rates over time, age

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Deng, Yang, Aiqun Li, and Dongming Feng. "Fatigue performance investigation for hangers of suspension bridges based on site-specific vehicle loads." Structural Health Monitoring 18, no. 3 (2018): 934–48. http://dx.doi.org/10.1177/1475921718786710.

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Hangers or suspenders of a suspension bridge are the primary load-carrying members and are vital to the structural integrity and service life of the bridge. Site-specific vehicle loads monitored by the weigh-in-motion system can assist to obtain the operational cyclic stresses of hangers. Differing from most existing studies, herein, a framework for fatigue performance investigation for hangers of suspension bridges is proposed utilizing the full information of the weigh-in-motion data. This framework includes four steps: (1) generate influence surfaces for hangers, (2) reconstruct vehicular l

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Wulandari, Eva Mei, Asri Dinapradipta, and Ima Defiana. "Perancangan Direksi Keet dan Hunian Sementara dengan Pendekatan Teritori Untuk Memperhatikan Privasi Pengguna." ARSITEKTURA 22, no. 1 (2024): 141. http://dx.doi.org/10.20961/arst.v22i1.83572.

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<p><em>The creation of territories on site offices and temporary housing can affect the activities within them. This study explores the criteria for territories in site offices and temporary housing through user comfort and privacy. Qualitative research methods were used, with data collection through primary and secondary sources. Primary data was collected from field studies on projects in East Java, while secondary data was obtained from literature studies. The results of this study are design criteria that can be used as a reference for designing site offices and temporary housi

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Sollazzo, Giuseppe, Sonia Longo, Maurizio Cellura, and Clara Celauro. "Impact Analysis Using Life Cycle Assessment of Asphalt Production from Primary Data." Sustainability 12, no. 24 (2020): 10171. http://dx.doi.org/10.3390/su122410171.

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Road construction and maintenance have a great impact on the environment, owing to the huge volumes of resources involved. Consequently, current production procedures and technologies must be properly investigated, for identifying and quantifying the life cycle environmental impacts produced. In this paper, primary data, i.e., site-specific data directly collected or measured on a reference plant, are analyzed for calculating the impact of the production of a hot mix asphalt. The analysis is performed in a from “cradle to gate” approach to estimate the environmental burdens of the production p

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Vybornov, Aleksandr, and Natalya Doga. "The Site of Kombak-te (Northern Caspian): Some New Data." Oriental Studies 17, no. 1 (2024): 110–22. http://dx.doi.org/10.22162/2619-0990-2024-71-1-110-122.

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Introduction. The article examines stone artifacts from a Northern Caspian Eneolithic site of the Khvalynsk culture. Stone tool industries also serve to characterize Early Metal Age cultures. Goals. The work seeks to determine the cultural affiliation of stone implements from the site of Kombak-te. To facilitate this, the paper shall analyze a variety of such stone implements and their groups. Materials and methods. The publication focuses on finds from the third major Khvalynsk site of Kombak-te. The latter was investigated in 1989 but only some pottery data were published. The article is the

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Kamel, Mohamed Gomaa, Amr Ehab El-Qushayri, Ahmed Kamal Sayed, and Nguyen Tien Huy. "Using the primary site as a prognostic tool for nodal mantle cell lymphoma: a SEER-based study." Journal of Comparative Effectiveness Research 9, no. 12 (2020): 861–76. http://dx.doi.org/10.2217/cer-2020-0083.

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Background: Nodal mantle cell lymphoma (NMCL) has a worse survival than extra-nodal mantle cell lymphoma. Materials & methods: A cohort study was conducted to evaluate the primary site role as a mortality predictor using data from 1983 to 2011 from the Surveillance, Epidemiology, and End Results (SEER) database. Results: Most patients had NMCL in multiple regions (71.9%). There was a significantly increased incidence of NMCL cases over years with 83.2% of them occurred between 1998 and 2011. The mean survival was 52.9 months with overall survival/cancer-specific survival rate of 29.2/42.9%

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Li, H., K. Qu, K. Tokoro, et al. "Identification of cancer of unknown primary with gene expression profiling." Journal of Clinical Oncology 24, no. 18_suppl (2006): 10052. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.10052.

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10052 Background: Patients with metastatic cancer of unknown primary (CUP) generally have a poor prognosis, with a median survival of 2–10 months. Conventional diagnostic approaches for identifying the primary tumor site are successful in only 20%-30% of cases; however, such identification provides prognostic information and helps with selection of tumor-specific therapy, leading to improved survival. Recent studies indicate that gene expression-based classification of CUP is highly successful in predicting the site of origin. We report herein development and validation of a method that determ

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Veazey, Ronald S., Marie-Claire Gauduin, Keith G. Mansfield, et al. "Emergence and Kinetics of Simian Immunodeficiency Virus-Specific CD8+ T Cells in the Intestines of Macaques during Primary Infection." Journal of Virology 75, no. 21 (2001): 10515–19. http://dx.doi.org/10.1128/jvi.75.21.10515-10519.2001.

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ABSTRACT In this report, three Mamu-A*01+ rhesus macaques were examined to compare the emergence of simian immunodeficiency virus (SIV)-specific CD8+ T cells in the intestines and blood in early SIV infection using a major histocompatibility complex class I tetramer complexed with the Gag181–189 peptide. Fourteen days after intravenous inoculation with SIVmac251, large numbers of SIV Gag181–189-specific CD8+ T cells were detected in the intestinal mucosa (3.1 to 11.5% of CD3+CD8+ lymphocytes) as well as in the blood (3.1 to 13.4%) of all three macaques. By 21 days postinoculation, levels of te

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Steiner, Laurie A., Vincent Schulz, Yelena Maksimova, Nancy E. Seidel, David M. Bodine, and Patrick G. Gallagher. "Unbiased Identification of Functional Barrier Insulators in Primary Human Erythroid Cells,." Blood 118, no. 21 (2011): 3385. http://dx.doi.org/10.1182/blood.v118.21.3385.3385.

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Abstract Abstract 3385 Barrier insulators function to actively maintain the boundaries between heterochromatin and euchromatin. They are critical for regulation of cell-type specific gene expression in normal development and differentiation. Mutations that disrupt barrier insulator function have been associated with developmental disorders, malignancies, and inherited hemolytic anemias. Barrier insulators are poorly understood in mammalian cells, with much of the available data coming from model organisms. In vertebrates, the best characterized barrier insulator is the 5' hypersensitive site i

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Liu, Jiaqi L., Emily V. Walker, Yuba Raj Paudel, Faith G. Davis, and Yan Yuan. "Brain Metastases among Cancer Patients Diagnosed from 2010–2017 in Canada: Incidence Proportion at Diagnosis and Estimated Lifetime Incidence." Current Oncology 29, no. 3 (2022): 2091–105. http://dx.doi.org/10.3390/curroncol29030169.

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The incidence of BM among Canadian cancer patients is unknown. We aimed to estimate IP of BM at the time of cancer diagnosis and during the lifetime of patients with selected primary cancers. Data on BM at diagnosis from 2010–2017 was obtained from the CCR. Site-specific IPs of BM were estimated from provincial registries containing ≥90% complete data on BM. The CCR IP estimates and the IP estimates from literature were applied to the total diagnosed primary cancers to estimate the number of concurrent BM and lifetime BM from 2010–2017 in Canada, respectively. The annual average number of pati

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Chiang, You-Hsuan, Je-Wei Hsu, Hsin-Lun Chiu, Chung-En Liu, Tzu-Yu Huang, and Yung-Ju Chang. "Verifying or Clarifying? User Preferences for Mobile Crowdsourcing in Response to Seemingly Inconsistent Sensor Data." Proceedings of the ACM on Human-Computer Interaction 9, no. 2 (2025): 1–35. https://doi.org/10.1145/3711100.

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In the realm of smart cities, sensor technologies play a pivotal role in monitoring urban facilities and environments, providing real-time, site-specific information to residents. However, discrepancies often arise in sensor data due to variances in granularity, abstraction, and scope, which can foster uncertainty regarding the actual conditions on-site. This study explores whether, under these circumstances, individuals prefer on-site mobile crowds for verification purposes or for the provision of supplementary contextual information to aid in decision-making. Conducting an online study with

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Manca, Paolo, Ayush V. Kris, Henry Walch, et al. "Abstract 3779: Genomic and clinical characterization of metastatic patterns using real-word data from a large cohort of colorectal cancer patients." Cancer Research 84, no. 6_Supplement (2024): 3779. http://dx.doi.org/10.1158/1538-7445.am2024-3779.

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Abstract Background: Colorectal cancers (CRCs) can exhibit disparate metastatic patterns that affect outcomes. We investigated associations between genomic features and organ-specific metastatic tropism and we compared the frequency of actionable alterations detected in patients undergoing longitudinal clinical sequencing. Methods: We analyzed data for 6574 tumors from 6153 CRC patients, including 4510 primary and 2064 metastatic specimens. All patients had microsatellite stable (MSS) disease and were treated at Memorial Sloan Kettering. Paired primary and metastatic samples were available for

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Adamo, Irene, Edgar Ortiz-Malavasi, Robin Chazdon, Priscila Chaverri, Hans ter Steege, and József Geml. "Soil Fungal Community Composition Correlates with Site-Specific Abiotic Factors, Tree Community Structure, and Forest Age in Regenerating Tropical Rainforests." Biology 10, no. 11 (2021): 1120. http://dx.doi.org/10.3390/biology10111120.

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Successional dynamics of plants and animals during tropical forest regeneration have been thoroughly studied, while fungal compositional dynamics during tropical forest succession remain unknown, despite the crucial roles of fungi in ecological processes. We combined tree data and soil fungal DNA metabarcoding data to compare richness and community composition along secondary forest succession in Costa Rica and assessed the potential roles of abiotic factors influencing them. We found a strong coupling of tree and soil fungal community structure in wet tropical primary and regenerating seconda

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McDaniel, Jaydene, Steven McDaniel, Beanca Jhanine Samiano, Matthew Marrujo, Karl Kingsley, and Katherine M. Howard. "Microbial Screening Reveals Oral Site-Specific Locations of the Periodontal Pathogen Selenomonas noxia." Current Issues in Molecular Biology 43, no. 1 (2021): 353–64. http://dx.doi.org/10.3390/cimb43010029.

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Introduction: Selenomonas noxia (SN) is an important periodontal pathogen, associated with gingivitis and periodontitis. Many studies have found associations between SN and indicators of poor health outcomes, such as smoking, low socioeconomic status and obesity. However, less is known about the prevalence of this organism and more specifically about other oral site-specific locations that may harbor this organism. Methods: Using an existing patient repository (n = 47) of DNA isolated from saliva and other oral sites (n = 235), including the dorsum of the tongue, lower lingual incisor, upper b

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Hao, Shuang, Liqun Chen, Wenhui Du, and Huiyan Sun. "A Comprehensive Comparison between Primary Liver Cancer and Liver Metastases through scRNA-Seq Data Analysis." Metabolites 14, no. 2 (2024): 90. http://dx.doi.org/10.3390/metabo14020090.

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Metastasis is one of the leading causes of cancer-related deaths. A comprehensive comparison of the differences between primary and metastatic cancers within the same organ can aid in understanding the growth mechanisms of cancer cells at metastatic sites, thereby helping to develop more effective targeted treatment strategies. Primary liver cancer is one of the most common types of cancer, and the liver is also one of the main metastatic sites. In this paper, we utilize single-cell RNA-Seq data to compare primary liver cancer and colorectal liver metastases from multiple perspectives, includi

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Marquardt, André, Philip Kollmannsberger, Markus Krebs, et al. "Visual Clustering of Transcriptomic Data from Primary and Metastatic Tumors—Dependencies and Novel Pitfalls." Genes 13, no. 8 (2022): 1335. http://dx.doi.org/10.3390/genes13081335.

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Personalized oncology is a rapidly evolving area and offers cancer patients therapy options that are more specific than ever. However, there is still a lack of understanding regarding transcriptomic similarities or differences of metastases and corresponding primary sites. Applying two unsupervised dimension reduction methods (t-Distributed Stochastic Neighbor Embedding (t-SNE) and Uniform Manifold Approximation and Projection (UMAP)) on three datasets of metastases (n = 682 samples) with three different data transformations (unprocessed, log10 as well as log10 + 1 transformed values), we visu

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Kuppel, S., P. Peylin, F. Maignan, et al. "Model–data fusion across ecosystems: from multisite optimizations to global simulations." Geoscientific Model Development 7, no. 6 (2014): 2581–97. http://dx.doi.org/10.5194/gmd-7-2581-2014.

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Abstract. This study uses a variational data assimilation framework to simultaneously constrain a global ecosystem model with eddy covariance measurements of daily net ecosystem exchange (NEE) and latent heat (LE) fluxes from a large number of sites grouped in seven plant functional types (PFTs). It is an attempt to bridge the gap between the numerous site-specific parameter optimization works found in the literature and the generic parameterization used by most land surface models within each PFT. The present multisite approach allows deriving PFT-generic sets of optimized parameters enhancin

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Pohl, Marie O., Idoia Busnadiego, Verena Kufner, et al. "SARS-CoV-2 variants reveal features critical for replication in primary human cells." PLOS Biology 19, no. 3 (2021): e3001006. http://dx.doi.org/10.1371/journal.pbio.3001006.

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Since entering the human population, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2; the causative agent of Coronavirus Disease 2019 [COVID-19]) has spread worldwide, causing >100 million infections and >2 million deaths. While large-scale sequencing efforts have identified numerous genetic variants in SARS-CoV-2 during its circulation, it remains largely unclear whether many of these changes impact adaptation, replication, or transmission of the virus. Here, we characterized 14 different low-passage replication-competent human SARS-CoV-2 isolates representing all major Euro

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Tucker-Kulesza, Stacey E., Gretchen F. Sassenrath, Tri Tran, Weston Koehn, and Lauren Erickson. "Site-Specific Erodibility in Claypan Soils: Dependence on Subsoil Characteristics." Applied Engineering in Agriculture 33, no. 5 (2017): 705–18. http://dx.doi.org/10.13031/aea.12120.

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Abstract. Soil erosion is a primary factor limiting the productive capacity of many crop production fields and contributing to sediment and nutrient impairments of water bodies. Loss of topsoil is especially critical for areas of limited topsoil depth, such as the claypan area of the central United States. More than a century of conventional agricultural practices have eroded the topsoil and, in places, exposed the unproductive clay layer. This clay layer is impervious, limiting water infiltration and root penetration, and severely restricting agricultural productivity. Previous studies have d

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Larsson, Susanna C., Siddhartha Kar, John R. B. Perry, et al. "Serum Estradiol and 20 Site-Specific Cancers in Women: Mendelian Randomization Study." Journal of Clinical Endocrinology & Metabolism 107, no. 2 (2021): e467-e474. http://dx.doi.org/10.1210/clinem/dgab713.

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Abstract Context The causal role of endogenous estradiol in cancers other than breast and endometrial cancer remains unclear. Objective This Mendelian randomization study assessed the causal associations of endogenous 17β-estradiol (E2), the most potent estrogen, with cancer risk in women. Methods As primary genetic instrument, we used a genetic variant in the CYP19A1 gene that is strongly associated with serum E2 levels. Summary statistics genetic data for the association of the E2 variant with breast, endometrial, and ovarian cancer were obtained from large-scale consortia. We additionally e

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Kim, Soo-Gin, Hong-Il Kwon, Jeoung-Seok Yoon, Chan-Hong Kim, Hyo Heo, and Chung-Mo Lee. "Site-Specific Hydrogeological Characterization for Radiological Safety: Integrating Groundwater Dynamics and Transport." Water 17, no. 2 (2025): 186. https://doi.org/10.3390/w17020186.

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The radiological impact of radionuclide transport via groundwater pathways at the Wolsong Low- and Intermediate-Level Waste (LILW) Disposal Center was estimated by considering site-specific characteristics, including hydrogeology, geochemistry, and land use. Human intrusion scenarios, such as groundwater well development, were analyzed to evaluate potential pumping volumes and radionuclide migration pathways. Particular attention was given to the hydrological and geochemical aspects of radionuclide transport, with a focus on local aquifer heterogeneity, flow dynamics, and interactions with eng

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Penuela, Maria, Nirav Patil, Gino Cioffi, Carol Kruchko, and Jill S. Barnholtz-Sloan. "EPID-29. CAUSES OF DEATH FOR PRIMARY BRAIN AND CNS TUMOR PATIENTS IN THE UNITED STATES (2001 – 2016): A POPULATION BASED STUDY." Neuro-Oncology 22, Supplement_2 (2020): ii84—ii85. http://dx.doi.org/10.1093/neuonc/noaa215.347.

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Abstract BACKGROUND Population-based data on the various causes of death among Primary Brain and CNS tumor patients are lacking. We evaluated the causes of death for all eligible patients using the National Program of Cancer Registries (NPCR) data. METHODS The population-based cancer survival data collected by the Centers for Disease Control and Prevention’s National Program of Cancer Registries (NPCR) were used to analyze the causes of death for patients of all ages with primary brain and CNS tumors diagnosed between 2001 and 2016. Patients for whom the cause of death was not listed on the de

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Hayashi, Hidetoshi, Yuichi Takiguchi, Hironobu Minami, et al. "NGSCUP: Phase II trial of site-specific treatment based on gene expression and mutation profiling by next generation sequencing (NGS) for patients (pts) with cancer of unknown primary site (CUP)." Journal of Clinical Oncology 38, no. 15_suppl (2020): e15577-e15577. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e15577.

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e15577 Background: Although gene profiling is a promising diagnostic technique to determine the tissue of origin for pts with CUP, we reported that site-specific treatment based on gene profiling using microarray did not result in an improvement the survival compared with empirical therapy in the previous randomized phase 2 trial (Hayashi, et. al, JCO 2019). Recently, we have established new integrative diagnostic system combined the gene expression from RNA-sequencing and mutation/copy number variation data from targeted genomic-sequencing using NGS. We have performed a single-arm phase 2 stu

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Heatherington, Craig, Alistair Grinham, Irene Penesis, Scott Hunter, and Remo Cossu. "Geotechnical Approach to Early-Stage Site Characterisation of Shallow Wave Energy Sites." Journal of Marine Science and Engineering 9, no. 6 (2021): 605. http://dx.doi.org/10.3390/jmse9060605.

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Marine renewable energy is still in its infancy and poses serious challenges due to the harsh marine conditions encountered for wave or tidal installations and the survivability of devices. Geophysical and hydrodynamic initial site surveys need to be able to provide repeatable, reliable, and economical solutions. An oscillating water column wave energy converter is to be installed on the west coast of King Island, Tasmania. The location is in a high-energy nearshore environment to take advantage of sustained shoaling non-breaking waves of the Southern Ocean and required site-specific informati

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Li, Fu Jun, Ranu Surolia, Huashi Li, et al. "Low-dose cadmium exposure induces peribronchiolar fibrosis through site-specific phosphorylation of vimentin." American Journal of Physiology-Lung Cellular and Molecular Physiology 313, no. 1 (2017): L80—L91. http://dx.doi.org/10.1152/ajplung.00087.2017.

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Exposure to cadmium (Cd) has been associated with development of chronic obstructive lung disease (COPD). The mechanisms and signaling pathways whereby Cd causes pathological peribronchiolar fibrosis, airway remodeling, and subsequent airflow obstruction remain unclear. We aimed to evaluate whether low-dose Cd exposure induces vimentin phosphorylation and Yes-associated protein 1 (YAP1) activation leading to peribronchiolar fibrosis and subsequent airway remodeling. Our data demonstrate that Cd induces myofibroblast differentiation and extracellular matrix (ECM) deposition around small (<2

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Palombo, Fabio, Andrea Monciotti, Alessandra Recchia, Riccardo Cortese, Gennaro Ciliberto, and Nicola La Monica. "Site-Specific Integration in Mammalian Cells Mediated by a New Hybrid Baculovirus–Adeno-Associated Virus Vector." Journal of Virology 72, no. 6 (1998): 5025–34. http://dx.doi.org/10.1128/jvi.72.6.5025-5034.1998.

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ABSTRACT Baculovirus can transiently transduce primary human and rat hepatocytes, as well as a subset of stable cell lines. To prolong transgene expression, we have developed new hybrid vectors which associate key elements from adeno-associated virus (AAV) with the elevated transducing capacity of baculovirus. The hybrid vectors contain a transgene cassette composed of the β-galactosidase (β-Gal) reporter gene and the hygromycin resistance (Hygr) gene flanked by the AAV inverted terminal repeats (ITRs), which are necessary for AAV replication and integration in the host genome. Constructs were

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Schiessl, Andreas, Richard Müller, Rebekka Volk, Konrad Zimmer, Patrick Breun, and Frank Schultmann. "Integrating site-specific environmental impact assessment in supplier selection: exemplary application to steel procurement." Journal of Business Economics 90, no. 9 (2020): 1409–57. http://dx.doi.org/10.1007/s11573-020-00967-1.

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Abstract In times of fast-growing stakeholder interest in sustainability, the ecological and social perspective of industrial companies and its products is gaining increasing importance. In particular, the emission of greenhouse gases (GHG) in the automotive industry has come to the forefront of public and governmental attention. The transport sector accounts for 27% of all European GHG emissions and constitutes the largest emitter of CO2e (CO2 equivalents) among all energy demanding technologies. Due to increasingly efficient combustion engines and technology innovation towards e-mobility, th

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MOIMAZ, Suzely Adas Saliba, Lúcia Maria Lima Lemos de MELO, Cléa Adas Saliba GARBIN, Artênio José Ísper GARBIN, and Nemre Adas SALIBA. "Oral health assessment protocol in primary care." RGO - Revista Gaúcha de Odontologia 63, no. 4 (2015): 446–54. http://dx.doi.org/10.1590/1981-863720150003000113012.

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Objective: The aim of this study was to analyze the oral health service performance in a certain municipality and also to develop a diagnostic evaluation protocol of Oral Health in Primary Care. Methods: This is a descriptive, quantitative and qualitative research. The research site chosen was in the city of Pereira Barreto, State of São Paulo Brazil, since it makes use of the Family Health Strategy as the structuring care model of the Health Care System in 100% of the population as well as oral health teams implemented and oral health secondary care. Data were obtained through interviews with

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Remigius, W. Dheelibun, and Anand Natarajan. "Identification of wind turbine main-shaft torsional loads from high-frequency SCADA (supervisory control and data acquisition) measurements using an inverse-problem approach." Wind Energy Science 6, no. 6 (2021): 1401–12. http://dx.doi.org/10.5194/wes-6-1401-2021.

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Abstract. To assess the structural health and remaining useful life of wind turbines within wind farms, the site-specific structural response and modal parameters of the primary structures are required. In this regard, a novel inverse-problem-based methodology is proposed here to identify the dynamic quantities of the drivetrain main shaft, i.e. torsional displacement and coupled stiffness. As a model-based approach, an inverse problem of a mathematical model concerning the coupled-shaft torsional dynamics with high-frequency SCADA (supervisory control and data acquisition) measurements as inp

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Kagan, Polina, Noy Horesh, Howard Amital, et al. "The Risk and Predictors of Malignancies in Ankylosing Spondylitis Patients in Israel—A Retrospective Electronic Data-Based Study." Journal of Clinical Medicine 12, no. 15 (2023): 5153. http://dx.doi.org/10.3390/jcm12155153.

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Background: Previous studies demonstrated unclear and vast variability in the association between Ankylosing Spondylitis (AS) and the risk of cancer. Objectives: To assess the risk of overall and site-specific malignancies for AS patients in Israel, while examining the role of comorbidities and immunomodulatory therapy. Methods: We conducted a retrospective electronic data-based study including all AS patients diagnosed between 2002 and 2018, with no history of cancer prior to enrollment, with 5:1 ratio matched-control by age, gender, and place of residence. The odds Ratios (OR) for site-speci

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Whitmore, Carly, Mona Emam, Pauline Pariser, and Blanca Bolea. "Implementation and adaptation of a hub-based psychiatric and primary care program: A qualitative descriptive analysis of The Seamless Care Optimizing the Patient Experience (SCOPE) Mental Health program." PLOS ONE 19, no. 5 (2024): e0303750. http://dx.doi.org/10.1371/journal.pone.0303750.

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Background The Seamless Care Optimizing the Patient Experience (SCOPE)–Mental Health program is a comprehensive case management and psychiatric care initiative that supports primary care physicians in independent medical practices. This program offers a range of services that aims to enhance primary care capacity for mental health and provide accessible clinical care for patients. With its flexible hub-based approach, this program allows participating sites to tailor their implementation based on their available resources and specific needs within their community. Objectives The aim of this qu

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Whitmore, Carly, Mona Emam, and Blanca Bolea Alamañac. "Adaptations of a hub-based integrated psychiatric and primary care program: Seamless Care Optimizing the Patient Experience (SCOPE) Mental Health Program." International Journal of Integrated Care 25 (April 9, 2025): 95. https://doi.org/10.5334/ijic.icic24363.

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Importance: The Seamless Care Optimizing the Patient Experience (SCOPE) – Mental Health program is a comprehensive case management and psychiatric care initiative that supports primary care physicians in independent medical practices. This program offers a range of services that aim to enhance primary care capacity for mental health and provide accessible clinical care for patients. With its flexible hub-based approach, this program allows participating sites to tailor their implementation based on their available resources and specific needs within their community. Objectives: The aim of this

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Barlow, Ellen L., Michael Jackson, and Neville F. Hacker. "The Prognostic Role of the Surgical Margins in Squamous Vulvar Cancer: A Retrospective Australian Study." Cancers 12, no. 11 (2020): 3375. http://dx.doi.org/10.3390/cancers12113375.

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For the last 30 years at the Royal Hospital for Women, unifocal vulvar squamous cancers have been treated by radical local excision, aiming to achieve a histopathological margin of ≥8 mm, equating to a surgical margin of 1 cm. The need for a margin of this width has recently been challenged. We aimed to determine the long-term outcome following this conservative approach, and the relationship between vulvar recurrences and surgical margins. Data were obtained retrospectively on 345 patients treated primarily with surgery for squamous vulvar cancer between 1987 and 2017. Median follow-up was 93

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Beebe, Caroline. "Standard Descriptive Vocabulary and Archaeology Digital Data Collection." Advances in Archaeological Practice 5, no. 3 (2017): 250–64. http://dx.doi.org/10.1017/aap.2017.15.

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ABSTRACTArchaeology has embraced the shift to digital technology for collecting, analyzing, and sharing data. Digital repositories are now recognized as essential for data stewardship and are setting standards for data deposition. These new technologies and systems support the scientific need for reproducible results through intra-cultural as well as cross-cultural hypothesis testing. Methods of digital data collection in the field, however, are often site specific, restricted by the limited availability of digital technologies, or not well suited for creating systems that support the requirem

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Wang, Yanhong, Yi Ouyang, Jingjing Su, Zhigang Bai, Qunrong Cai, and Xinping Cao. "Role of locoregional surgery in treating FIGO 2009 stage IVB cervical cancer patients: a population-based study." BMJ Open 11, no. 8 (2021): e042364. http://dx.doi.org/10.1136/bmjopen-2020-042364.

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ObjectiveWe aimed to analyse the clinical value of primary site surgery in improving the cancer-specific survival (CSS) and overall survival (OS) of initial metastatic cervical cancer patients.DesignA population-based retrospective study.SettingNational Cancer Institute’s Surveillance, Epidemiology and End Results database.ParticipantsWe analysed 1390 patients with the International Federation of Gynecology and Obstetrics 2009 stage IVB cervical cancer with complete clinical data treated between 2010 and 2016.InterventionsPrimary site surgery.MeasuresPropensity score matching (PSM) with a rati

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Advani, Pragati Gole, Christina R. Crabtree-Ide, Sarah Mullin, et al. "Risk patterns for second primary malignancies among human papillomavirus (HPV)–associated first primary cancer survivors in the United States." Journal of Clinical Oncology 43, no. 16_suppl (2025): 10516. https://doi.org/10.1200/jco.2025.43.16_suppl.10516.

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10516 Background: Previous studies have shown an increased risk of second primary malignancies (SPMs) among human papillomavirus (HPV)-associated first primary cancer (FPC) survivors; however, this has not been comprehensively examined by cancer site and patient’s sex. We utilized a large population-based database to examine disparities in SPM risk by site of HPV-associated first and second cancers. Methods: From 17 United States population-based Surveillance, Epidemiology and End Results (SEER) program cancer registry areas, we identified 124,802 ≥12-month survivors of HPV-associated invasive

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Zhong, Miaochun, Farhana Zerin Khan, Xianghong He, Lingfei Cui, Kefeng Lei, and Minghua Ge. "Impact of Lung Metastasis versus Metastasis of Bone, Brain, or Liver on Overall Survival and Thyroid Cancer-Specific Survival of Thyroid Cancer Patients: A Population-Based Study." Cancers 14, no. 13 (2022): 3133. http://dx.doi.org/10.3390/cancers14133133.

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We investigate the impact of lung metastasis versus metastasis of bone, brain, or liver on overall survival (OS) and thyroid cancer-specific survival (TCSS) in patients with thyroid cancer (TC). Therefore, de-identified SEER 18 registry data of primary TC patients diagnosed between 2010 and 2016 were analyzed. The primary outcome was the prognosis of TC patients with lung metastasis compared with other sites. The secondary outcomes included the prognosis comparison between patients with and without surgery and between single and multiple metastasis sites. Isolated lung metastasis was associate

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Strongman, Helen, Rachael Williams, and Krishnan Bhaskaran. "What are the implications of using individual and combined sources of routinely collected data to identify and characterise incident site-specific cancers? a concordance and validation study using linked English electronic health records data." BMJ Open 10, no. 8 (2020): e037719. http://dx.doi.org/10.1136/bmjopen-2020-037719.

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ObjectivesTo describe the benefits and limitations of using individual and combinations of linked English electronic health data to identify incident cancers.Design and settingOur descriptive study uses linked English Clinical Practice Research Datalink primary care; cancer registration; hospitalisation and death registration data.Participants and measuresWe implemented case definitions to identify first site-specific cancers at the 20 most common sites, based on the first ever cancer diagnosis recorded in each individual or commonly used combination of data sources between 2000 and 2014. We c

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Spokas, Kurt, and Frank Forcella. "Estimating hourly incoming solar radiation from limited meteorological data." Weed Science 54, no. 1 (2006): 182–89. http://dx.doi.org/10.1614/ws-05-098r.1.

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Two major properties that determine weed seed germination are soil temperature and moisture content. Incident radiation is the primary variable controlling energy input to the soil system and thereby influences both moisture and temperature profiles. However, many agricultural field sites lack proper instrumentation to measure solar radiation directly. To overcome this shortcoming, an empirical model was developed to estimate total incident solar radiation (beam and diffuse) with hourly time steps. Input parameters for the model are latitude, longitude, and elevation of the field site, along w

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