Log in

Relevant bibliographies by topics / SIV Envelope Glycoprotein / Journal articles

To see the other types of publications on this topic, follow the link: SIV Envelope Glycoprotein.

Journal articles on the topic 'SIV Envelope Glycoprotein'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'SIV Envelope Glycoprotein.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Chen, Bing, Yifan Cheng, Lesley Calder, et al. "A Chimeric Protein of Simian Immunodeficiency Virus Envelope Glycoprotein gp140 and Escherichia coli Aspartate Transcarbamoylase." Journal of Virology 78, no. 9 (2004): 4508–16. http://dx.doi.org/10.1128/jvi.78.9.4508-4516.2004.

Full text

Abstract:

ABSTRACT The envelope glycoproteins of the human immunodeficiency virus and the related simian immunodeficiency virus (SIV) mediate viral entry into host cells by fusing viral and target cell membranes. We have reported expression, purification, and characterization of gp140 (also called gp160e), the soluble, trimeric ectodomain of the SIV envelope glycoprotein, gp160 (B. Chen et al., J. Biol. Chem. 275:34946-34953, 2000). We have now expressed and purified chimeric proteins of SIV gp140 and its variants with the catalytic subunit (C) of Escherichia coli aspartate transcarbamoylase (ATCase). T

APA, Harvard, Vancouver, ISO, and other styles

2

Schenten, Dominik, Luisa Marcon, Gunilla B. Karlsson, et al. "Effects of Soluble CD4 on Simian Immunodeficiency Virus Infection of CD4-Positive and CD4-Negative Cells." Journal of Virology 73, no. 7 (1999): 5373–80. http://dx.doi.org/10.1128/jvi.73.7.5373-5380.1999.

Full text

Abstract:

ABSTRACT A soluble form of the CD4 receptor (sCD4) can either enhance or inhibit the infection of cells by simian immunodeficiency virus (SIV) and human immunodeficiency virus. We investigated the basis for these varying effects by studying the entry of three SIV isolates into CD4-positive and CD4-negative cells expressing different chemokine receptors. Infection of CD4-negative cells depended upon the viral envelope glycoproteins and upon the chemokine receptor, with CCR5 and gpr15 being more efficient than STRL33. Likewise, enhancement of infection by sCD4 was observed when CCR5- and gpr15-e

APA, Harvard, Vancouver, ISO, and other styles

3

Sauter, M. M., A. Pelchen-Matthews, R. Bron, et al. "An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface." Journal of Cell Biology 132, no. 5 (1996): 795–811. http://dx.doi.org/10.1083/jcb.132.5.795.

Full text

Abstract:

A Tyr to Cys mutation at amino acid position 723 in the cytoplasmic domain of the simian immunodeficiency virus (SIV) transmembrane (TM) molecule has been shown to increase expression of envelope glycoproteins on the surface of infected cells. Here we show that Tyr-723 contributes to a sorting signal that directs the rapid endocytosis of viral glycoproteins from the plasma membrane via coated pits. On cells infected by SIVs with a Tyr at position 723, envelope glycoproteins were transiently expressed on the cell surface and then rapidly endocytosed. Similar findings were noted for envelope mol

APA, Harvard, Vancouver, ISO, and other styles

4

Evans, David T., Karl C. Tillman, and Ronald C. Desrosiers. "Envelope Glycoprotein Cytoplasmic Domains from Diverse Lentiviruses Interact with the Prenylated Rab Acceptor." Journal of Virology 76, no. 1 (2002): 327–37. http://dx.doi.org/10.1128/jvi.76.1.327-337.2002.

Full text

Abstract:

ABSTRACT Lentivirus envelope glycoproteins have unusually long cytoplasmic domains compared to those of other retroviruses. To identify cellular binding partners of the simian immunodeficiency virus (SIV) envelope transmembrane protein (gp41) cytoplasmic domain (CD), we performed a yeast two-hybrid screen of a phytohemagglutinin-activated human T-cell cDNA library with the SIV gp41 CD. The majority of positive clones (50 of 54) encoded the prenylated Rab acceptor (PRA1). PRA1 is a 21-kDa protein associated with Golgi membranes that binds to prenylated Rab proteins in their GTP-bound state. Whi

APA, Harvard, Vancouver, ISO, and other styles

5

Vzorov, A. N., and R. W. Compans. "Effect of the Cytoplasmic Domain of the Simian Immunodeficiency Virus Envelope Protein on Incorporation of Heterologous Envelope Proteins and Sensitivity to Neutralization." Journal of Virology 74, no. 18 (2000): 8219–25. http://dx.doi.org/10.1128/jvi.74.18.8219-8225.2000.

Full text

Abstract:

ABSTRACT In addition to the viral envelope (Env) proteins, host cell-derived proteins have been reported to be present in human immunodeficiency virus and simian immunodeficiency virus (SIV) envelopes, and it has been postulated that they may play a role in infection. We investigated whether the incorporation of host cell proteins is affected by the structure and level of incorporation of viral Env proteins. To compare the cellular components incorporated into SIV particles and how this is influenced by the structure of the cytoplasmic domain, we compared SIV virions with full-length and trunc

APA, Harvard, Vancouver, ISO, and other styles

6

Hart, T. K., A. M. Klinkner, J. Ventre, and P. J. Bugelski. "Morphometric analysis of envelope glycoprotein gp120 distribution on HIV-1 virions." Journal of Histochemistry & Cytochemistry 41, no. 2 (1993): 265–71. http://dx.doi.org/10.1177/41.2.7678271.

Full text

Abstract:

The surface of HIV-1, like that of other retroviruses, is studied with virally encoded glycoproteins which appear ultrastructurally as electron-dense spikes or knobs. The glycoprotein that forms the spike structure, gp120, is non-covalently bound to the transmembrane glycoprotein gp41. Mature HIV-1 virions do not have as many spikes as the genetically related retroviruses HIV-2 and SIV. gp120 is lost from HIV-1 during viral morphogenesis and after incubation of the virus with the soluble form of cellular receptor CD4. In this study we used ultrastructural cytochemistry and morphometry to quant

APA, Harvard, Vancouver, ISO, and other styles

7

Chertova, Elena, Julian W. Bess,, Bruce J. Crise, et al. "Envelope Glycoprotein Incorporation, Not Shedding of Surface Envelope Glycoprotein (gp120/SU), Is the Primary Determinant of SU Content of Purified Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus." Journal of Virology 76, no. 11 (2002): 5315–25. http://dx.doi.org/10.1128/jvi.76.11.5315-5325.2002.

Full text

Abstract:

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) particles typically contain small amounts of the surface envelope protein (SU), and this is widely believed to be due to shedding of SU from mature virions. We purified proteins from HIV-1 and SIV isolates using procedures which allow quantitative measurements of viral protein content and determination of the ratios of gag- and env-encoded proteins in virions. All of the HIV-1 and most of the SIV isolates examined contained low levels of envelope proteins, with Gag:Env ratios of approximately 60:1. Bas

APA, Harvard, Vancouver, ISO, and other styles

8

Hu, S., K. Abrams, G. Barber, et al. "Protection of macaques against SIV infection by subunit vaccines of SIV envelope glycoprotein gp160." Science 255, no. 5043 (1992): 456–59. http://dx.doi.org/10.1126/science.1531159.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Berlioz-Torrent, Clarisse, Barbara L. Shacklett, Lars Erdtmann, et al. "Interactions of the Cytoplasmic Domains of Human and Simian Retroviral Transmembrane Proteins with Components of the Clathrin Adaptor Complexes Modulate Intracellular and Cell Surface Expression of Envelope Glycoproteins." Journal of Virology 73, no. 2 (1999): 1350–61. http://dx.doi.org/10.1128/jvi.73.2.1350-1361.1999.

Full text

Abstract:

ABSTRACT The cytoplasmic domains of the transmembrane (TM) envelope proteins (TM-CDs) of most retroviruses have a Tyr-based motif, YXXØ, in their membrane-proximal regions. This signal is involved in the trafficking and endocytosis of membrane receptors via clathrin-associated AP-1 and AP-2 adaptor complexes. We have used CD8-TM-CD chimeras to investigate the role of the Tyr-based motif of human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV), and human T-leukemia virus type 1 (HTLV-1) TM-CDs in the cell surface expression of the envelope glycoprotein. Flow cytometry

APA, Harvard, Vancouver, ISO, and other styles

10

Manrique, Julieta M., Cristina C. P. Celma, Eric Hunter, José L. Affranchino, and Silvia A. González. "Positive and Negative Modulation of Virus Infectivity and Envelope Glycoprotein Incorporation into Virions by Amino Acid Substitutions at the N Terminus of the Simian Immunodeficiency Virus Matrix Protein." Journal of Virology 77, no. 20 (2003): 10881–88. http://dx.doi.org/10.1128/jvi.77.20.10881-10888.2003.

Full text

Abstract:

ABSTRACT The matrix (MA) protein of the simian immunodeficiency viruses (SIVs) is encoded by the amino-terminal region of the Gag precursor and is the component of the viral capsid that lines the inner surface of the virus envelope. Previously, we identified domains in the SIV MA that are involved in the transport of Gag to the plasma membrane and in particle assembly. In this study, we characterized the role in the SIV life cycle of highly conserved residues within the SIV MA region spanning the two N-terminal α-helices H1 and H2. Our analyses identified two classes of MA mutants: (i) viruses

APA, Harvard, Vancouver, ISO, and other styles

11

Frank, I., M. Piatak, H. Stoessel, et al. "Infectious and Whole Inactivated Simian Immunodeficiency Viruses Interact Similarly with Primate Dendritic Cells (DCs): Differential Intracellular Fate of Virions in Mature and Immature DCs." Journal of Virology 76, no. 6 (2002): 2936–51. http://dx.doi.org/10.1128/jvi.76.6.2936-2951.2002.

Full text

Abstract:

ABSTRACT As potential targets for human immunodeficiency virus type 1 and simian immunodeficiency virus (HIV-1 and SIV), dendritic cells (DCs) likely play a significant role in the onset and spread of infection as well as in the induction of antiviral immunity. Using the SIV-macaque system to study the very early events in DC-virus interactions, we compared chemically inactivated SIV having conformationally and functionally intact envelope glycoproteins (2,2′-dithiodipyridine [AT-2] SIV) to infectious and heat-treated SIV. Both human and macaque DCs interact similarly with SIV without detectab

APA, Harvard, Vancouver, ISO, and other styles

12

Furchner, Michelle, Ann L. Erickson, Todd Allen, et al. "The Simian Immunodeficiency Virus Envelope Glycoprotein Contains Two Epitopes Presented by the Mamu-A*01 Class I Molecule." Journal of Virology 73, no. 10 (1999): 8035–39. http://dx.doi.org/10.1128/jvi.73.10.8035-8039.1999.

Full text

Abstract:

ABSTRACT Cytotoxic T lymphocyte (CTL) responses against the simian immunodeficiency virus (SIV) envelope and Gag proteins were monitored in a Mamu-A*01-positive rhesus macaque infected with SIVsmE660. Peripheral blood mononuclear cells (PBMC) cultured with synthetic peptides spanning the entire gp160 and Gag coding region recognized a total of three epitopes. One located in Gag was identified as the previously described Mamu-A*01-restricted p11cC→M epitope (CTPYDINQM). The other two epitopes, designated p15m and p54m, were located in the gp160 envelope protein. Both were nine amino acids in le

APA, Harvard, Vancouver, ISO, and other styles

13

Maleeff, Beverly E., Timothy K. Hart, James A. Hoxie, and Peter J. Bugelski. "Structural studies of immunodeficiency viruses." Proceedings, annual meeting, Electron Microscopy Society of America 53 (August 13, 1995): 698–99. http://dx.doi.org/10.1017/s042482010013986x.

Full text

Abstract:

Immunodeficiency viruses (IV) are retroviruses belonging to the subfamily Lentivirinae and include human (HIV) and simian (SIV) immunodeficiency viruses. In this study, we focus on the structure of proteins in SIV isolated from macaques (SIVmac). IV form by budding through the surface of an infected cell, where viral proteins and RNA are enveloped by the host cell bilayer membrane. Immature virions consist of this outer membrane studded with surface glycoprotein projections and a thick sub-envelope protein plaque composed of unprocessed Pr55gag protein. Viral maturation is marked by cleavage o

APA, Harvard, Vancouver, ISO, and other styles

14

Yuste, Eloísa, Welkin Johnson, George N. Pavlakis, and Ronald C. Desrosiers. "Virion Envelope Content, Infectivity, and Neutralization Sensitivity of Simian Immunodeficiency Virus." Journal of Virology 79, no. 19 (2005): 12455–63. http://dx.doi.org/10.1128/jvi.79.19.12455-12463.2005.

Full text

Abstract:

ABSTRACT A truncating E767stop mutation was introduced into the envelope glycoprotein of simian immunodeficiency virus (SIV) strain SIV239-M5 (moderately sensitive to antibody-mediated neutralization and lacking five sites for N-linked carbohydrate attachment) and strain SIV316 (very sensitive to neutralization, with eight amino acid changes from the neutralization-resistant parental molecular clone, SIV239). The truncating mutation increased Env content in virions, increased infectivity, and decreased sensitivity to antibody-mediated neutralization in both strains. However, the magnitude of t

APA, Harvard, Vancouver, ISO, and other styles

15

Hirsch, Vanessa M., George Dapolito, Anna Hahn, et al. "Viral Genetic Evolution in Macaques Infected with Molecularly Cloned Simian Immunodeficiency Virus Correlates with the Extent of Persistent Viremia." Journal of Virology 72, no. 8 (1998): 6482–89. http://dx.doi.org/10.1128/jvi.72.8.6482-6489.1998.

Full text

Abstract:

ABSTRACT Genetic evolution of the simian immunodeficiency virus (SIV) envelope glycoprotein was evaluated in a group of six macaques (Macaca nemestrina) infected with the molecularly cloned, moderately pathogenic SIVsm62d. The extent of envelope evolution was subsequently evaluated within the context of the individual pattern of viremia and disease outcome. Two macaques in this cohort developed AIDS by 1.5 years postinoculation (progressors), whereas the remaining four macaques remained asymptomatic (nonprogressors). Compared with the nonprogressor macaques, the two progressor macaques exhibit

APA, Harvard, Vancouver, ISO, and other styles

16

Crooks, Emma T., Pengfei Jiang, Michael Franti, et al. "Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization." Virology 377, no. 2 (2008): 364–78. http://dx.doi.org/10.1016/j.virol.2008.04.045.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Iwamoto, Nami, Rosemarie D. Mason, Kaimei Song та ін. "Blocking α4β7 integrin binding to SIV does not improve virologic control". Science 365, № 6457 (2019): 1033–36. http://dx.doi.org/10.1126/science.aaw7765.

Full text

Abstract:

A study in nonhuman primates reported that infusions of an antibody against α4β7 integrin, in combination with antiretroviral therapy, showed consistent, durable control of simian immunodeficiency virus (SIV) in rhesus macaques. The antibody used has pleiotropic effects, so we set out to gain insight into the underlying mechanism by comparing this treatment to treatment with non-neutralizing monoclonal antibodies against the SIV envelope glycoprotein that only block α4β7 binding to SIV Env but have no other host-directed effects. Similar to the initial study, we used an attenuated strain of SI

APA, Harvard, Vancouver, ISO, and other styles

18

von Bredow, Benjamin, Juan F. Arias, Lisa N. Heyer, et al. "Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity." Journal of Virology 89, no. 20 (2015): 10648–55. http://dx.doi.org/10.1128/jvi.01911-15.

Full text

Abstract:

ABSTRACTThe cytoplasmic tails of human and simian immunodeficiency virus (HIV and SIV, respectively) envelope glycoproteins contain a highly conserved, membrane-proximal endocytosis motif that prevents the accumulation of Env on the surface of infected cells prior to virus assembly. Using an assay designed to measure the killing of virus-infected cells by antibody-dependent cell-mediated cytotoxicity (ADCC), we show that substitutions in this motif increase the susceptibility of HIV-1- and SIV-infected cells to ADCC in a manner that directly correlates with elevated Env levels on the surface o

APA, Harvard, Vancouver, ISO, and other styles

19

Chen, Bing, Erik M. Vogan, Haiyun Gong, John J. Skehel, Don C. Wiley, and Stephen C. Harrison. "Determining the Structure of an Unliganded and Fully Glycosylated SIV gp120 Envelope Glycoprotein." Structure 13, no. 2 (2005): 197–211. http://dx.doi.org/10.1016/j.str.2004.12.004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Torres, José V., David E. Anderson, Arthur Malley, et al. "SIV envelope glycoprotein epitopes recognized by antibodies from infected or vaccinated rhesus macaques." Journal of Medical Primatology 22, no. 2-3 (1993): 129–37. http://dx.doi.org/10.1111/j.1600-0684.1993.tb00651.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Quiñones-Kochs, Miriam I., Linda Buonocore, and John K. Rose. "Role of N-Linked Glycans in a Human Immunodeficiency Virus Envelope Glycoprotein: Effects on Protein Function and the Neutralizing Antibody Response." Journal of Virology 76, no. 9 (2002): 4199–211. http://dx.doi.org/10.1128/jvi.76.9.4199-4211.2002.

Full text

Abstract:

ABSTRACT The envelope (Env) glycoprotein of human immunodeficiency virus (HIV) contains 24 N-glycosylation sites covering much of the protein surface. It has been proposed that one role of these carbohydrates is to form a shield that protects the virus from immune recognition. Strong evidence for such a role for glycosylation has been reported for simian immunodeficiency virus (SIV) mutants lacking glycans in the V1 region of Env (J. N. Reitter, R. E. Means, and R. C. Desrosiers, Nat. Med. 4:679-684, 1998). Here we used recombinant vesicular stomatitis viruses (VSVs) expressing HIV Env glycosy

APA, Harvard, Vancouver, ISO, and other styles

22

McKee, Hayley J., and David S. Strayer. "Immune responses against SIV envelope glycoprotein, using recombinant SV40 as a vaccine delivery vector." Vaccine 20, no. 29-30 (2002): 3613–25. http://dx.doi.org/10.1016/s0264-410x(02)00243-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

PLANELLES, VICENTE, NANCY L. HAIGWOOD, MARTA L. MARTHAS, et al. "Functional and Immunological Characterization of SIV Envelope Glycoprotein Produced in Genetically Engineered Mammalian Cells." AIDS Research and Human Retroviruses 7, no. 11 (1991): 889–98. http://dx.doi.org/10.1089/aid.1991.7.889.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Malvoisin, Etienne, and Fabian Wild. "Inhibition of HIV-1, HIV-2 and SIV envelope glycoprotein-mediated cell fusion by calmodulin." Virus Research 50, no. 2 (1997): 119–27. http://dx.doi.org/10.1016/s0168-1702(97)00060-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Luciw, Paul A., Karen E. S. Shaw, Barbara L. Shacklett, and Marta L. Marthas. "Importance of the Intracytoplasmic Domain of the Simian Immunodeficiency Virus (SIV) Envelope Glycoprotein for Pathogenesis." Virology 252, no. 1 (1998): 9–16. http://dx.doi.org/10.1006/viro.1998.9467.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Swanstrom, Adrienne E., Gregory Q. Del Prete, Claire Deleage, Samra E. Elser, Andrew A. Lackner, and James A. Hoxie. "The SIV Envelope Glycoprotein, Viral Tropism, and Pathogenesis: Novel Insights from Nonhuman Primate Models of AIDS." Current HIV Research 16, no. 1 (2018): 29–40. http://dx.doi.org/10.2174/1570162x15666171124123116.

Full text

Abstract:

Background: Cellular tropism of human immunodeficiency virus (HIV-1) is closely linked to interactions between the viral envelope glycoprotein (Env) with CD4 and chemokine receptor family members, CCR5 and CXCR4. This interaction plays a key role in determining anatomic sites that are infected in vivo and the cascade of early and late events that result in chronic immune activation, immunosuppression and ultimately, AIDS. CD4+ T cells are critical to adaptive immune responses, and their early and rapid infection in gut lamina propria and secondary lymphoid tissues in susceptible hosts likely c

APA, Harvard, Vancouver, ISO, and other styles

27

Le Tortorec, Anna, and Stuart J. D. Neil. "Antagonism to and Intracellular Sequestration of Human Tetherin by the Human Immunodeficiency Virus Type 2 Envelope Glycoprotein." Journal of Virology 83, no. 22 (2009): 11966–78. http://dx.doi.org/10.1128/jvi.01515-09.

Full text

Abstract:

ABSTRACT Tetherin (CD317/BST-2), an interferon-induced membrane protein, restricts the release of nascent retroviral particles from infected cell surfaces. While human immunodeficiency virus type 1 (HIV-1) encodes the accessory gene vpu to overcome the action of tetherin, the lineage of primate lentiviruses that gave rise to HIV-2 does not. It has been previously reported that the HIV-2 envelope glycoprotein has a Vpu-like function in promoting virus release. Here we demonstrate that the HIV-2 Rod envelope glycoprotein (HIV-2 Rod Env) is a tetherin antagonist. Expression of HIV-2 Rod Env, but

APA, Harvard, Vancouver, ISO, and other styles

28

Means, Robert E., and Ronald C. Desrosiers. "Resistance of Native, Oligomeric Envelope on Simian Immunodeficiency Virus to Digestion by Glycosidases." Journal of Virology 74, no. 23 (2000): 11181–90. http://dx.doi.org/10.1128/jvi.74.23.11181-11190.2000.

Full text

Abstract:

ABSTRACT Stocks of simian immunodeficiency virus (SIV) from the supernatants of infected cell cultures were used to examine the sensitivity of envelope glycoprotein gp120 to enzymatic deglycosylation and the effects of enzyme treatment on infectivity. Sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis and Western blot analysis revealed little or no change in the mobility of virion-associated gp120 after digestion with high concentrations of N-glycosidase F, endoglycosidase F, endoglycosidase H, and endo-β-galactosidase. Soluble gp120, which was not pelletable after the enzymatic r

APA, Harvard, Vancouver, ISO, and other styles

29

Johnson, Welkin E., Jennifer Morgan, Julie Reitter, et al. "A Replication-Competent, Neutralization-Sensitive Variant of Simian Immunodeficiency Virus Lacking 100 Amino Acids of Envelope." Journal of Virology 76, no. 5 (2002): 2075–86. http://dx.doi.org/10.1128/jvi.76.5.2075-2086.2002.

Full text

Abstract:

ABSTRACT Coding sequences for the first two variable loops of the gp120 envelope glycoprotein were removed from simian immunodeficiency virus (SIV) strain 239 (SIVmac239). This deletion encompassed 100 amino acids. The resulting virus replicated poorly after transfection into immortalized T-cell lines, with peak replication occurring only after 25 to 30 days. Limited passaging of SIVmac239ΔV1V2 in cultures gave rise to a variant which had significantly improved replication kinetics but which retained the original 100-amino-acid deletion in gp120. Cloning and sequencing revealed 11 changes in t

APA, Harvard, Vancouver, ISO, and other styles

30

SILVERA, P., B. FLANAGAN, K. KENT, et al. "Fine Analysis of Humoral Antibody Response to Envelope Glycoprotein of SIV in Infected and Vaccinated Macaques." AIDS Research and Human Retroviruses 10, no. 10 (1994): 1295–304. http://dx.doi.org/10.1089/aid.1994.10.1295.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Fultz, Patricia N., Patricia J. Vance, Michael J. Endres, et al. "In Vivo Attenuation of Simian Immunodeficiency Virus by Disruption of a Tyrosine-Dependent Sorting Signal in the Envelope Glycoprotein Cytoplasmic Tail." Journal of Virology 75, no. 1 (2001): 278–91. http://dx.doi.org/10.1128/jvi.75.1.278-291.2001.

Full text

Abstract:

ABSTRACT Attenuated simian immunodeficiency viruses (SIVs) have been described that produce low levels of plasma virion RNA and exhibit a reduced capacity to cause disease. These viruses are particularly useful in identifying viral determinants of pathogenesis. In the present study, we show that mutation of a highly conserved tyrosine (Tyr)-containing motif (Yxxφ) in the envelope glycoprotein (Env) cytoplasmic tail (amino acids YRPV at positions 721 to 724) can profoundly reduce the in vivo pathogenicity of SIVmac239. This domain constitutes both a potent endocytosis signal that reduces Env ex

APA, Harvard, Vancouver, ISO, and other styles

32

Gardner, Matthew R., Christoph H. Fellinger, Lisa M. Kattenhorn, et al. "AAV-delivered eCD4-Ig protects rhesus macaques from high-dose SIVmac239 challenges." Science Translational Medicine 11, no. 502 (2019): eaau5409. http://dx.doi.org/10.1126/scitranslmed.aau5409.

Full text

Abstract:

A number of simian and simian human immunodeficiency viruses (SIV and SHIV, respectively) have been used to assess the efficacy of HIV-1 vaccine strategies. Among these, SIVmac239 is considered among the most stringent because, unlike SHIV models, its full genome has coevolved in its macaque host and its tier 3 envelope glycoprotein (Env) is exceptionally hard to neutralize. Here, we investigated the ability of eCD4-Ig, an antibody-like entry inhibitor that emulates the HIV-1 and SIV receptor and coreceptor, to prevent SIVmac239 infection. We show that rh-eCD4-IgI39N expressed by recombinant a

APA, Harvard, Vancouver, ISO, and other styles

33

BAHBOUHI, Bouchaib, Nathalie CHAZAL, Nabil Georges SEIDAH, et al. "Effects of l- and d-REKR amino acid-containing peptides on HIV and SIV envelope glycoprotein precursor maturation and HIV and SIV replication." Biochemical Journal 366, no. 3 (2002): 863–72. http://dx.doi.org/10.1042/bj20020052.

Full text

Abstract:

The aim of the present study was to evaluate the capacity of synthetic l- and d-peptides encompassing the HIV-1BRU gp160 REKR cleavage site to interfere with HIV and simian immuno-deficiency virus (SIV) replication and maturation of the envelope glycoprotein (Env) precursors. To facilitate their penetration into cells, a decanoyl (dec) group was added at the N-terminus. The sequences synthesized included dec5d or dec5l (decREKRV), dec9d or dec9l (decRVVQREKRV) and dec14d or dec14l (TKAKRRVVQREKRV). The peptide dec14d was also prepared with a chloromethane (cmk) group as C-terminus. Because l-p

APA, Harvard, Vancouver, ISO, and other styles

34

Mangeot, Philippe-Emmanuel, Didier Nègre, Bertrand Dubois, et al. "Development of Minimal Lentivirus Vectors Derived from Simian Immunodeficiency Virus (SIVmac251) and Their Use for Gene Transfer into Human Dendritic Cells." Journal of Virology 74, no. 18 (2000): 8307–15. http://dx.doi.org/10.1128/jvi.74.18.8307-8315.2000.

Full text

Abstract:

ABSTRACT Lentivirus-derived vectors are very promising gene delivery systems since they are able to transduce nonproliferating differentiated cells, while murine leukemia virus-based vectors can only transduce cycling cells. Here we report the construction and characterization of highly efficient minimal vectors derived from simian immunodeficiency virus (SIVmac251). High-fidelity PCR amplification of DNA fragments was used to generate a minimal SIV vector formed from a 5′ cytomegalovirus early promoter, the 5′ viral sequences up to the 5′ end of gagrequired for reverse transcription and packa

APA, Harvard, Vancouver, ISO, and other styles

35

Saunders, Cheryl J., Ruth A. McCaffrey, Irina Zharkikh, et al. "The V1, V2, and V3 Regions of the Human Immunodeficiency Virus Type 1 Envelope Differentially Affect the Viral Phenotype in an Isolate-Dependent Manner." Journal of Virology 79, no. 14 (2005): 9069–80. http://dx.doi.org/10.1128/jvi.79.14.9069-9080.2005.

Full text

Abstract:

ABSTRACT It is well documented that removal of the V1V2 region or of the V2 loop alone from the envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) or simian immunodeficiency virus (SIV) increases the susceptibility of these viruses to neutralization by antibodies. The specific role of the V1 loop in defining the neutralization susceptibility of HIV is, however, not well documented. Our current studies indicate that although the V1V2 region is a global modulator of the HIV-1 neutralization susceptibility, the individual roles the V1 and V2 loops have in defining the neutraliza

APA, Harvard, Vancouver, ISO, and other styles

36

Wyss, Stéphanie, Antony S. Dimitrov, Frédéric Baribaud, Terri G. Edwards, Robert Blumenthal, and James A. Hoxie. "Regulation of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Fusion by a Membrane-Interactive Domain in the gp41 Cytoplasmic Tail." Journal of Virology 79, no. 19 (2005): 12231–41. http://dx.doi.org/10.1128/jvi.79.19.12231-12241.2005.

Full text

Abstract:

ABSTRACT Truncation of the human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) gp41 cytoplasmic tail (CT) can modulate the fusogenicity of the envelope glycoprotein (Env) on infected cells and virions. However, the CT domains involved and the underlying mechanism responsible for this “inside-out” regulation of Env function are unknown. HIV and SIV CTs are remarkably long and contain amphipathic alpha-helical domains (LLP1, LLP2, and LLP3) that likely interact with cellular membranes. Using a cell-cell fusion assay and a panel of HIV Envs with stop codons at various positi

APA, Harvard, Vancouver, ISO, and other styles

37

OHKAWA, SUSUMU, KEYU XU, LAWRENCE A. WILSON, RONALD MONTELARO, LOUIS N. MARTIN, and MICHAEL MURPHEY-CORB. "Analysis of Envelope Glycoprotein-Specific Antibodies from SIV-Infected and gp110-Immunized Monkeys in ACC and ADCC Assays." AIDS Research and Human Retroviruses 11, no. 3 (1995): 395–403. http://dx.doi.org/10.1089/aid.1995.11.395.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Kim, Mikyung, Bing Chen, Rebecca E. Hussey, et al. "The Stoichiometry of Trimeric SIV Glycoprotein Interaction with CD4 Differs from That of Anti-envelope Antibody Fab Fragments." Journal of Biological Chemistry 276, no. 46 (2001): 42667–76. http://dx.doi.org/10.1074/jbc.m104166200.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Ohgimoto, Shinji, Tatsuo Shioda, Kazuyasu Mori, Emi E. Nakayama, Huiling Hu, and Yoshiyuki Nagai. "Location-Specific, Unequal Contribution of the N Glycans in Simian Immunodeficiency Virus gp120 to Viral Infectivity and Removal of Multiple Glycans without Disturbing Infectivity." Journal of Virology 72, no. 10 (1998): 8365–70. http://dx.doi.org/10.1128/jvi.72.10.8365-8370.1998.

Full text

Abstract:

ABSTRACT One of the striking features of human immunodeficiency virus, simian immunodeficiency virus (SIV), and other lentiviruses is extensive N glycosylation of the envelope protein. To assess the requirement of each N glycan for viral infectivity, we individually silenced all 23 N glycosylation sites in the gp120 subunit of SIVmac239 envelope protein by mutagenizing the canonical Asn-Xaa-Thr/Ser N glycosylation motif in an infectious molecular clone, attempted to rescue viruses from the clones, and compared the replication capability of the rescued viruses in MT4 cells. The mutation resulte

APA, Harvard, Vancouver, ISO, and other styles

40

Ding, Shilei, Halima Medjahed, Jérémie Prévost, Mathieu Coutu, Shi-Hua Xiang, and Andrés Finzi. "Lineage-Specific Differences between the gp120 Inner Domain Layer 3 of Human Immunodeficiency Virus and That of Simian Immunodeficiency Virus." Journal of Virology 90, no. 22 (2016): 10065–73. http://dx.doi.org/10.1128/jvi.01215-16.

Full text

Abstract:

ABSTRACT Binding of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) gp120 exterior envelope glycoprotein to CD4 triggers conformational changes in gp120 that promote its interaction with one of the chemokine receptors, usually CCR5, ultimately leading to gp41-mediated virus-cell membrane fusion and entry. We previously described that topological layers (layer 1, layer 2, and layer 3) in the gp120 inner domain contribute to gp120-trimer association in the unliganded state but also help secure CD4 binding. Relative to layer 1 of HIV-1 gp120, the SIVmac239 gp12

APA, Harvard, Vancouver, ISO, and other styles

41

Liu, Ze, Hongqiang Lv, Jiuqiang Han, and Ruiling Liu. "A computational model for predicting transmembrane regions of retroviruses." Journal of Bioinformatics and Computational Biology 15, no. 03 (2017): 1750010. http://dx.doi.org/10.1142/s021972001750010x.

Full text

Abstract:

Transmembrane region (TR) is a conserved region of transmembrane (TM) subunit in envelope (env) glycoprotein of retrovirus. Evidences have shown that TR is responsible for anchoring the env glycoprotein on the lipid bilayer and substitution of the TR for a covalently linked lipid anchor abrogates fusion. However, universal software could not achieve sufficient accuracy as TM in env also has several motifs such as signal peptide, fusion peptide and immunosuppressive domain composed largely of hydrophobic residues. In this paper, a support vector machine-based (SVM) model is proposed to identify

APA, Harvard, Vancouver, ISO, and other styles

42

Pegu, Poonam, Monica Vaccari, Shari Gordon, et al. "Antibodies with High Avidity to the gp120 Envelope Protein in Protection from Simian Immunodeficiency Virus SIVmac251Acquisition in an Immunization Regimen That Mimics the RV-144 Thai Trial." Journal of Virology 87, no. 3 (2012): 1708–19. http://dx.doi.org/10.1128/jvi.02544-12.

Full text

Abstract:

ABSTRACTThe recombinant canarypox vector, ALVAC-HIV, together with human immunodeficiency virus (HIV) gp120 envelope glycoprotein, has protected 31.2% of Thai individuals from HIV acquisition in the RV144 HIV vaccine trial. This outcome was unexpected, given the limited ability of the vaccine components to induce CD8+T-cell responses or broadly neutralizing antibodies. We vaccinated macaques with an immunization regimen intended to mimic the RV144 trial and exposed them intrarectally to a dose of the simian immunodeficiency virus SIVmac251that transmits few virus variants, similar to HIV trans

APA, Harvard, Vancouver, ISO, and other styles

43

Russell, Ronnie M., Frederic Bibollet-Ruche, Weimin Liu, et al. "CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses." Proceedings of the National Academy of Sciences 118, no. 13 (2021): e2025914118. http://dx.doi.org/10.1073/pnas.2025914118.

Full text

Abstract:

Infection with human and simian immunodeficiency viruses (HIV/SIV) requires binding of the viral envelope glycoprotein (Env) to the host protein CD4 on the surface of immune cells. Although invariant in humans, the Env binding domain of the chimpanzee CD4 is highly polymorphic, with nine coding variants circulating in wild populations. Here, we show that within-species CD4 diversity is not unique to chimpanzees but found in many African primate species. Characterizing the outermost (D1) domain of the CD4 protein in over 500 monkeys and apes, we found polymorphic residues in 24 of 29 primate sp

APA, Harvard, Vancouver, ISO, and other styles

44

Laird, Melissa E., and Ronald C. Desrosiers. "Infectivity and Neutralization of Simian Immunodeficiency Virus with FLAG Epitope Insertion in gp120 Variable Loops." Journal of Virology 81, no. 20 (2007): 10838–48. http://dx.doi.org/10.1128/jvi.00831-07.

Full text

Abstract:

ABSTRACT A FLAG epitope tag was substituted within variable loop 1 (V1), 2 (V2), or 4 (V4) of the gp120 envelope glycoprotein of simian immunodeficiency virus strain 239 (SIV239) to evaluate the extent to which each variable loop may serve as a target for antibody-mediated neutralization. Two sites within each variable loop of SIV239 were chosen for individual epitope tag insertions. FLAG epitope substitutions were also made in the V1, V2, and V4 loops of a neutralization-sensitive derivative of SIV239, SIV316. Of the 10 FLAG-tagged recombinant viruses analyzed, three (SIV239FV1b, SIV239FV2b,

APA, Harvard, Vancouver, ISO, and other styles

45

Boyd, David F., Dylan Peterson, Beth S. Haggarty, et al. "Mutations in HIV-1 Envelope That Enhance Entry with the Macaque CD4 Receptor Alter Antibody Recognition by Disrupting Quaternary Interactions within the Trimer." Journal of Virology 89, no. 2 (2014): 894–907. http://dx.doi.org/10.1128/jvi.02680-14.

Full text

Abstract:

ABSTRACTChimeric simian immunodeficiency virus (SIV)/human immunodeficiency virus (HIV) (SHIV) infection of macaques is commonly used to model HIV type 1 (HIV-1) transmission and pathogenesis in humans. Despite the fact that SHIVs encode SIV antagonists of the known macaque host restriction factors, these viruses require additional adaptation for replication in macaques to establish a persistent infection. Additional adaptation may be required in part because macaque CD4 (mCD4) is a suboptimal receptor for most HIV-1 envelope glycoprotein (Env) variants. This requirement raises the possibility

APA, Harvard, Vancouver, ISO, and other styles

46

Reitter, Julie N., and Ronald C. Desrosiers. "Identification of Replication-Competent Strains of Simian Immunodeficiency Virus Lacking Multiple Attachment Sites for N-Linked Carbohydrates in Variable Regions 1 and 2 of the Surface Envelope Protein." Journal of Virology 72, no. 7 (1998): 5399–407. http://dx.doi.org/10.1128/jvi.72.7.5399-5407.1998.

Full text

Abstract:

ABSTRACT Carbohydrates comprise about 50% of the mass of gp120, the external envelope glycoprotein of simian immunodeficiency virus (SIV) and human immunodeficiency virus. We identified 11 replication-competent derivatives of SIVmac239 lacking two, three, four, or five potential sites for N-linked glycosylation. These sites were located within and around variable regions 1 and 2 of the surface envelope protein of the virus. Asn (AAT) of the canonical N-linked glycosylation recognition sequence (Asn X Ser/Thr) was changed in each case to the structurally similar Gln (CAG or CAA) such that two n

APA, Harvard, Vancouver, ISO, and other styles

47

Burton, Samantha L., Katie M. Kilgore, S. Abigail Smith, et al. "Breakthrough of SIV strain smE660 challenge in SIV strain mac239-vaccinated rhesus macaques despite potent autologous neutralizing antibody responses." Proceedings of the National Academy of Sciences 112, no. 34 (2015): 10780–85. http://dx.doi.org/10.1073/pnas.1509731112.

Full text

Abstract:

Although the correlates of immunological protection from human immunodeficiency virus or simian immunodeficiency virus infection remain incompletely understood, it is generally believed that medium to high titers of serum neutralizing antibodies (nAbs) against the challenge virus will prevent infection. This paradigm is based on a series of studies in which passive transfer of HIV-specific nAbs protected rhesus macaques (RMs) from subsequent mucosal challenge with a chimeric human/simian immunodeficiency virus. However, it is unknown whether nAb titers define protection in the setting of activ

APA, Harvard, Vancouver, ISO, and other styles

48

Moore, Michael J., Tatyana Dorfman, Wenhui Li, et al. "Retroviruses Pseudotyped with the Severe Acute Respiratory Syndrome Coronavirus Spike Protein Efficiently Infect Cells Expressing Angiotensin-Converting Enzyme 2." Journal of Virology 78, no. 19 (2004): 10628–35. http://dx.doi.org/10.1128/jvi.78.19.10628-10635.2004.

Full text

Abstract:

ABSTRACT Infection of receptor-bearing cells by coronaviruses is mediated by their spike (S) proteins. The coronavirus (SARS-CoV) that causes severe acute respiratory syndrome (SARS) infects cells expressing the receptor angiotensin-converting enzyme 2 (ACE2). Here we show that codon optimization of the SARS-CoV S-protein gene substantially enhanced S-protein expression. We also found that two retroviruses, simian immunodeficiency virus (SIV) and murine leukemia virus, both expressing green fluorescent protein and pseudotyped with SARS-CoV S protein or S-protein variants, efficiently infected

APA, Harvard, Vancouver, ISO, and other styles

49

Breed, Matthew W., Samra E. Elser, Workineh Torben, et al. "Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif." Journal of Virology 89, no. 20 (2015): 10156–75. http://dx.doi.org/10.1128/jvi.01134-15.

Full text

Abstract:

ABSTRACTDeletion of Gly-720 and Tyr-721 from a highly conserved GYxxØ trafficking signal in the SIVmac239 envelope glycoprotein cytoplasmic domain, producing a virus termed ΔGY, leads to a striking perturbation in pathogenesis in rhesus macaques (Macaca mulatta). Infected macaques develop immune activation and progress to AIDS, but with only limited and transient infection of intestinal CD4+T cells and an absence of microbial translocation. Here we evaluated ΔGY in pig-tailed macaques (Macaca nemestrina), a species in which SIVmac239 infection typically leads to increased immune activation and

APA, Harvard, Vancouver, ISO, and other styles

50

Yen, Po-Jen, Megan E. Mefford, James A. Hoxie, Kenneth C. Williams, Ronald C. Desrosiers, and Dana Gabuzda. "Identification and characterization of a macrophage-tropic SIV envelope glycoprotein variant in blood from early infection in SIVmac251-infected macaques." Virology 458-459 (June 2014): 53–68. http://dx.doi.org/10.1016/j.virol.2014.03.024.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!