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Journal articles on the topic 'Siwe Disease'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Shalyga, I. F., G. V. Tishchenko, L. A. Martemyanova, S. Yu Turchenko, and Yu N. Avizhets. "Letterer-Siwe disease." Health and Ecology Issues, no. 2 (June 28, 2018): 99–103. http://dx.doi.org/10.51523/2708-6011.2018-15-2-20.

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The article describes a case of Letterer-Siwe disease (Langerhans cells histocytosis, histiocytosis X) in a 1-year-old infant, presents the authors` own observations focusing on the macroscopic and histological picture of skin lesions. The work also notes difficulties of diagnosis of this disease. Reliable morphological features of Letterer-Siwe disease were revealed during the histologic examination of the skin.

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2

Nyholm, Kåre, George Reed, and Knud-Erik Sjølin. "LETTERER-SIWE DISEASE." Acta Pathologica Microbiologica Scandinavica 70, no. 4 (2009): 481–500. http://dx.doi.org/10.1111/j.1699-0463.1967.tb01316.x.

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3

Novice, Fred M., Daniel W. Collison, D'Anne M. Kleinsmith, Michael E. Osband, John H. Burdakin, and Ralph J. Coskey. "Letterer-siwe disease in adults." Cancer 63, no. 1 (1989): 166–74. http://dx.doi.org/10.1002/1097-0142(19890101)63:1<166::aid-cncr2820630127>3.0.co;2-a.

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4

Natsume, Hiromune, Tetsuya Yamaguchi, Junko Ohsawa, et al. "Splenic infarction in Letterer-Siwe disease." Pediatrics International 47, no. 3 (2005): 329–32. http://dx.doi.org/10.1111/j.1442-200x.2005.02070.x.

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5

H H, Suad, Mona Mohamed Elamin, Gad Allah Modawe, and Khalid AbdElmohsin Awad Elseed. "Letterer Siwe Disease (LSD): A Case Report." Sudan Journal of Medical Sciences 13, no. 3 (2018): 207. http://dx.doi.org/10.18502/sjms.v13i3.2958.

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Background: Letterer Siwe Disease (LSD) is one of variants of langerhans cell histiocytosis (LCH) which is considered as a rare disease that affects many systems in the body, it is characterized by monoclonal migration and proliferation of specific dendritic cells. The disease affects the bones and skin primarily, but can involve other organs as well or appear as a multi-system disease leading to different clinical manifestations and eventually death.

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6

Shimizu, Tohru, Noriko Fukushima, Yoshiro Ebihara, Tetsutaro Sata, and Yuzo Aoyama. "GIANT CELL PNEUMONIA IN LETTERER-SIWE DISEASE." Pathology International 37, no. 3 (1987): 493–501. http://dx.doi.org/10.1111/j.1440-1827.1987.tb00383.x.

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7

Claudy, A. L., B. Larbre, M. Colomb, V. Levigne, and V. Deville. "Letterer-Siwe disease and subacute monocytic leukemia." Journal of the American Academy of Dermatology 21, no. 5 (1989): 1105–6. http://dx.doi.org/10.1016/s0190-9622(89)70306-6.

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8

Wright, Andrew L., William F. G. Tucker, David N. Slater, and Christine I. Harrington. "Letterer-Siwe disease in the ninth decade." Journal of the American Academy of Dermatology 12, no. 2 (1985): 369–71. http://dx.doi.org/10.1016/s0190-9622(85)80059-1.

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9

Al-Mohannadi, Muneera, Rafie Yakoub, Madiha E. Soofi, Hesham Mahmoud A. Elsabah, and Ragesh Babu Thandassery. "Gastrointestinal: Letterer Siwe disease: An uncommon gastrointestinal presentation." Journal of Gastroenterology and Hepatology 31, no. 6 (2016): 1070. http://dx.doi.org/10.1111/jgh.13293.

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10

Balakrishnan, R., Dipak Ranjan Nayak, and K. Deepak Murty. "Letterer-siwe disease with bilateral temporal bone involvement." American Journal of Otolaryngology 18, no. 1 (1997): 76–79. http://dx.doi.org/10.1016/s0196-0709(97)90054-5.

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11

Wankhade, VaishaliH, BhagyashreeBabanrao Supekar, TejalDevidas Ghanate, and RajeshPratap Singh. "Successful treatment of an uncommon disorder: Letterer-siwe disease." Indian Journal of Drugs in Dermatology 6, no. 2 (2020): 91. http://dx.doi.org/10.4103/ijdd.ijdd_49_19.

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12

SUDA, Koichi, Masako MITSUMATA, Toshio OYAMA, et al. "Two cases of Letterer-Siwe disease. A cytologic study." Journal of the Japanese Society of Clinical Cytology 25, no. 6 (1986): 1060–64. http://dx.doi.org/10.5795/jjscc.25.1060.

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13

Pant, C., P. N. Madonia, R. Bass та M. Jeroudi. "LANGERHANSʼ CELL HISTIOCYTOSIS: A CASE OF LETTERER-SIWE DISEASE." Journal of Investigative Medicine 55, № 1 (2007): S270. http://dx.doi.org/10.1097/00042871-200701010-00661.

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14

Aldred, M. J., P. J. Crawford, B. L. Chadwick, A. Day, and N. Dallimore. "Precocious tooth eruption and loss in Letterer-Siwe disease." British Dental Journal 165, no. 10 (1988): 367–70. http://dx.doi.org/10.1038/sj.bdj.4806640.

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15

Patel, Jigna, Dharmender Jairam, Kajal G. Kansara, Tejasvi Patel, and Bela J. Shah. "Letterer–Siwe disease: a case of multisystem Langerhans cell histiocytosis." Egyptian Journal of Dermatology and Venereology 44, no. 2 (2024): 120–24. http://dx.doi.org/10.4103/ejdv.ejdv_18_23.

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Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, is an idiopathic uncommon haematological condition affecting infants and young children but can occur at any age group characterized by clonal proliferation of abnormal Langerhans cells. Langerhans cells express an immunophenotype positive for S100 protein, CD1a and Langerin (CD207). Here we present a case of 2-year-old male patient presented with a multiple raw area associated with oozing, bleeding and crusted lesions were present over scalp, trunk and post-auricular areas. Radiographic examination revealed multiple ost

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16

Kashihara-Sawami, Mari, Yuji Horiguchi, Kouichi Ikai, et al. "Letterer-Siwe disease: Immunopathologic study with a new monoclonal antibody." Journal of the American Academy of Dermatology 18, no. 4 (1988): 646–54. http://dx.doi.org/10.1016/s0190-9622(88)70085-7.

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17

Appel, James E., J. Scott Kasteler, Vilma C. Fabre, and Jeffrey P. Callen. "NEONATAL LUPUS ERYTHEMATOSUS WITH CUTANEOUS FEATURES OF LETTERER-SIWE DISEASE." Southern Medical Journal 91, Supplement (1998): S24. http://dx.doi.org/10.1097/00007611-199810001-00043.

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18

Yakovlev, Y. Y., F. K. Manerov, O. I. Andriyanova, et al. "THE CASE OF LANGERHANS CELL HISTIOCYTOSIS (ABT–LETTERER–SIWE DISEASE) IN TWIN GIRLS." Pediatria. Journal named after G.N. Speransky 97, no. 4 (2018): 141–45. http://dx.doi.org/10.24110/0031-403x-2018-97-4-141-145.

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19

MORIKAWA, Mitsuya, Hatsumi FUJII, Kazuyuki SANDA, Masaru OHASHI, and Haruki Iwamura. "A case of Letterer-Siwe disease surviving 2 years after onset." Skin Cancer 4, no. 1 (1989): 222–25. http://dx.doi.org/10.5227/skincancer.4.222.

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20

Latifa, Alanazi* Ghada Alhindi Yara Alanazi Sarah Alseneidi Bashayer Alanazi Dalal Alshagha Munira Alghufaily Nada Dammas. "LANGERHANS CELL HISTIOCYTOSIS: STORY OF THE ORPHAN DISEASE BEYOND DERMATOLOGY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 06, no. 01 (2019): 2840–47. https://doi.org/10.5281/zenodo.2555667.

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<em>Langerhans cell histiocytosis (LCH), a rare proliferative disorder of cells that share phenotypic characteristics with dermal Langerhans cells, has long been considered an “orphan,” or neglected disease. Prior to its current designation, LCH was known as Hand–Schuller–Christian disease, Letterer–Siwe disease, or eosinophilic granuloma, which was combined under the umbrella designation of Histiocytosis X. The pathogenesis of LCH has remained unclear since the initial reports approximately 100 years earlier, and gene expression studies have demonstrated that the

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21

Agarwal, Preeti, Fatima Khan, Vaibhav Gupta, and Devanshi Dubey. "Liquid based cytology and immunohistochemistry on cytosmears based diagnosis of letterer-siwe disease in a 40 year male." Indian Journal of Pathology and Oncology 8, no. 4 (2021): 508–11. http://dx.doi.org/10.18231/j.ijpo.2021.105.

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: Histiocytes with coffee bean like nucleus are the diagnostic hallmark of Langerhans cell histiocytosis (LCH) supported with immunohistochemical (IHC) demonstration of fascin, CD1a and S-100. We report a case of Letterer-Siwe disease in a 40year male diagnosed on cytology and IHC on cytosmears along with cytomorphology in Liquid based cytology (LBC) smears. Forty year male presented with complains of low grade fever and reduced appetite from two years with a cervical swelling and discomfort from five months. Fine needle aspiration(FNA) from cervical lymph node showed sheets of histiocytes in

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22

Tsuchiya, H., F. Ishibashi, Masahiro Migita, Shinji Mutoh, and Izumi Akaboshi. "Perirenal mass of Langerhans cell histiocytosis (Letterer-Siwe disease) and percutaneous nephrostomy tube placement." European Journal of Pediatrics 154, no. 2 (1995): 117–19. http://dx.doi.org/10.1007/s004310050259.

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23

Tsuchiya, Hiroyuki, Fuminari Ishibashi, Masahiro Migita, Shinji Mutoh, and Izumi Akboshi. "Perirenal mass of Langerhans cell histiocytosis (Letterer-Siwe disease) and percutaneous nephrostomy tube placement." European Journal of Pediatrics 154, no. 2 (1995): 117–19. http://dx.doi.org/10.1007/bf01991913.

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24

Saha, Kanu Lal, Bishnu Pada Dey, Md Abul Hasnat Joarder, Mohammad Anamul Haque, and Bishwajit Bhowmik. "Bilateral Langerhans Cells Histiocytosis in the Temporal Bone: A case report." Bangladesh Journal of Otorhinolaryngology 26, no. 1 (2020): 68–72. http://dx.doi.org/10.3329/bjo.v26i1.47956.

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Langerhans cells histiocytosis (LCH) or histiocytosis-X is a rare group diseases that includes three overlapping diseases of Hand-Schuller-Christian disease (HSC), Letterer-Siwe disease (LS)and Eosinophilic granuloma(EG). It results from clonal proliferation of histiocytes having similar morphology and immunophenotype to Langerhans cells in skin and mucosa Though head and neck manifestation is common, isolated simultaneous bilateral temporal bone Langerhans Cell Histiocytosis is an extremely rare presentation. Having same otological menifestations, high resolution CT scan is advocated for earl

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25

Zanuncio, Virginia Vinha, Luciana Rabelo de Carvalho, Antônio Carlos Martins Guedes, Cláudia Márcia Resende Silva, and Bernardo Gontijo. "Case for diagnosis." Anais Brasileiros de Dermatologia 88, no. 6 (2013): 1001–3. http://dx.doi.org/10.1590/abd1806-4841.20132451.

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Langerhans cell histiocytosis is a rare, clinically heterogeneous desease. Since there is considerable clinical overlap among the four described variants (Hand-Schüller-Christian, eosinophilic granuloma, Letterer-Siwe and Hashimoto-Pritzker), the concept of spectral disease applies to this entity. The Hashimoto-Pritzker variant was first described in 1973. Characteristically, it is present at birth or during the first days of life, impairment is limited to the skin and prognosis is favorable with spontaneous resolution. We report a newborn male patient with Hashimoto-Pritzker disease presentin

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26

Ruco, L. P., D. Remotti, F. Monardo, et al. "Letterer-Siwe disease: Immunohistochemical evidence for a proliferative disorder involving immature cells of Langerhans lineage." Virchows Archiv A Pathological Anatomy and Histopathology 413, no. 3 (1988): 239–47. http://dx.doi.org/10.1007/bf00718616.

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27

Papochieva, Vera E., Dimitrinka S. Miteva, Penka I. Perenovska, and Guergana Petrova. "Langerhans-Cell Histiocytoses - Epidemiology, Classification, Clinical Features, Diagnosis, Complications, Treatment and Prognosis." Journal of Biomedical and Clinical Research 9, no. 1 (2016): 3–16. http://dx.doi.org/10.1515/jbcr-2016-0001.

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Summary Histiocytoses comprise a group of diverse diseases of unknown etiology with various clinical presentation and evolution. The underlying pathology is characterised by accumulation and infiltration of variable numbers of cells of the monocyte-macrophage line in the affected tissues and organs. Histiocytoses are divided into three major classes: Langerhans cell histiocytosis (LCH), non- Langerhans cell histiocytosis, and malignant histiocytic disorders. The term LCH (also known in the past as histiocytosis X) encompasses the following rare diseases: Eosinophilic Granuloma, Hand-Schuller-C

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28

Rolim, Larissa Santos Amaral, Helder Domiciano Dantas Martins, Eduarda Gomes Onofre de Araújo, et al. "Multisystemic presentation of langerhans cell histiocytosis in pediatric patient: a case report of letterer-siwe disease." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 139, no. 5 (2025): e1. https://doi.org/10.1016/j.oooo.2025.01.008.

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29

Forrest, E., S. J. Gallacher, D. Hadley, M. Soukop, and I. T. Boyle. "Central Nervous System Histiocytosis X — Imaging and Responses to Chemotherapy." Scottish Medical Journal 38, no. 5 (1993): 148–49. http://dx.doi.org/10.1177/003693309303800507.

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Histiocytosis X is the term first coined by Lichtenstein in 19531 to describe a heterogeneous group of disorders which is considered now to include Hand-Schuller-Christian disease, Letterer-Siwe disease and Eosinophilic Granuloma of bone. Gagel, in 1941, first described involvement of the central nervous system (CNS) in Histiocytosis X2 - in this case the hypothalamus and posterior pituitary were the areas principally affected. CNS involvement outwith these areas is rare, generally difficult to diagnose3, and little information on treatment is available. In this case we describe a man with cra

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30

Jayachandran, S., and N. Balaji. "Langerhans Cell Histiocytosis." World Journal of Dentistry 2, no. 1 (2011): 57–62. http://dx.doi.org/10.5005/jp-journals-10015-1055.

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ABSTRACT Langerhans cell histiocytosis (LCH) is rare unique disorder of the reticuloendothelial system characterized by an abnormal proliferation of histiocytes and eosinophilic leukocytes. Lichtenstein gave the term Histiocytosis X in 1953 to include three clinical varieties; Eosinophilic granuloma, Hand-Schüller-Christian disease and Letterer-Siwe disease, which shared some common histologic features and clinical findings. In 1973, the term LCH was introduced as an alternative to histiocytosis X. LCH may manifest orally with single or multiple lesions of the alveolar or basal bone, ulcerated

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31

Iupati, Douglas, and Sarat Chander. "A Case Report of Langerhans Histiocytosis Presenting Sequentially Over a 21-year Period With Letterer-Siwe Disease, Hand-Schuller-Christian Disease and Eosinophillic Granuloma of Bone." Journal of Pediatric Hematology/Oncology 28, no. 11 (2006): 746–49. http://dx.doi.org/10.1097/01.mph.0000243650.51487.ff.

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32

Barbosa, Breno, and Paulo Ronaldo Jube Ribeiro. "Surgical Treatment of Langerhans Cell Histiocytosis of Cervical Spine: Case-Report and Systematic Review of Literature." Archives of Pediatric Neurosurgery 7, no. 1 (2025): e2702025. https://doi.org/10.46900/apn.v7i1.270.

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Background: Langerhans cell histiocytosis (LCH) is a rare disease involving the cervical spine. This condition is present firstly in the thoracic spine, commonest, followed by the lumbar spine and cervical spine. In Langerhans cell histiocytosis there is excessive proliferation of pathologic Langerhans cells. It is commonly found in males with a ratio of 2.5:1. The etiology of LCH is unknown. There are three defined entities classified on their severities. Letterer-Siwe disease involves multiple organs, Hand-Schuller-Christian disease presents with bony lesions and endocrine abnormalities, and

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Pavlovic, Milos, Aleksandra Minic, Lidija Zolotarevski, and Sonja Vesic. "Disseminated crusted papules in a newborn." Vojnosanitetski pregled 63, no. 7 (2006): 681–83. http://dx.doi.org/10.2298/vsp0607681p.

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Background. Congenital self-healing Langerhans cell histiocytosis (Hashimoto-Pritzker disease) is the rarest form of Langerhans cell histiocytosis, usually confined to the skin and/or mucous membranes. Cutaneous eruption is mostly generalized, papular, nodular or vesicular. Despite impressive clinical presentation in a newborn it infrequently spreads to internal organs (which then portends a grave prognosis, indistinguishable from Letterer-Siwe disease). Case report. We presented a full-term newborn, female, 3.3 kg who had a multitude of erythematous and crusted papules, nodules and pseudovesi

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Morgan, Kelli W., and Jeffrey P. Callen. "Self-Healing Congenital Langerhans Cell Histiocytosis Presenting as Neonatal Papulovesicular Eruption." Journal of Cutaneous Medicine and Surgery 5, no. 6 (2001): 486–89. http://dx.doi.org/10.1177/120347540100500605.

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Background: Congenital self-healing Langerhans cell histiocytosis (CSHLCH) is a rare condition which may present at birth or during the neonatal period. It is usually characterized by the eruption of multiple, disseminated, red-brown papules and nodules which may increase in size and number during the first few weeks of life. Systemic signs are usually absent except for occasional mild hepatomegaly. Objective: We present a 3.5-kg male infant who presented at birth with numerous diffuse, erythematous, crusted erosions. He was presumed to have congenital herpes simplex virus (HSV) and was starte

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35

Steiner, Quynh-Giao, Luc A. Otten, M. John Hicks та ін. "In vivo transformation of mouse conventional CD8α+ dendritic cells leads to progressive multisystem histiocytosis". Blood 111, № 4 (2008): 2073–82. http://dx.doi.org/10.1182/blood-2007-06-097576.

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Division and proliferation of dendritic cells (DCs) have been proposed to contribute to homeostasis and to prolonged antigen presentation. Whether abnormal proliferation of dendritic cells causes Langerhans cell histiocytosis (LCH) is a highly debated topic. Transgenic expression of simian virus 40 (SV40) T antigens in mature DCs allowed their transformation in vivo while maintaining their phenotype, function, and maturation capacity. The transformed cells were differentiated splenic CD8 alpha–positive conventional dendritic cells with increased Langerin expression. Their selective transformat

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36

Allen, Carl E. "Langerhans Cell Histiocytosis: Back to Histiocytosis X." Blood 120, no. 21 (2012): SCI—8—SCI—8. http://dx.doi.org/10.1182/blood.v120.21.sci-8.sci-8.

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Abstract Abstract SCI-8 Langerhans cell histiocytosis (LCH) is a disorder characterized by inflammatory lesions that include pathologic CD207+ dendritic cells. LCH has pleotropic clinical presentations ranging from single lesions cured by curettage to potentially fatal multisystem disease. The first descriptions of LCH, including Hand-Schüller-Christian disease and Letterer-Siwe disease, were based on anatomic location and extent of the lesions. Despite clinical heterogeneity, LCH lesions are generally indistinguishable by histology, which led to the notion that the spectrum of clinical manif

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37

Hasniah, Minna, Prasetyadi Mawardi, Ambar Mudigdo, Elok Nurfaiqoh, and Fitri Kasmitasari. "Multi-System Histiocytosis of Langerhans Cells in Boys Aged 2 Years (Histopathology Review)." Jurnal Health Sains 2, no. 12 (2021): 1665–76. http://dx.doi.org/10.46799/jhs.v2i12.373.

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Langerhans cell histiocytosis (HSL) or histiocytosis X, eosinophilic granuloma, letterer siwe disease, hand schuller christian disease and hashimoto pritzker disease is a disorder caused by the accumulation and proliferation of langerhans cells in various organs of the body that causes tissue damage. The highest prevalence of HSL occurs in children less than 3 years old, with a ratio of 2:1 for boys and girls. The classic appearance of skin manifestations is an eruption resembling seborrheic dermatitis in the folds, axillae, scalp, retroauricular and trunk areas. The appearance of the lesion i

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Sahoo, Chinmaya Keshari, Subrat Kumar Tripathy, and Amiyakanta Mishra. "Management of Inflammatory Bowel Diseases: A Review." Saudi Journal of Medical and Pharmaceutical Sciences 8, no. 10 (2022): 622–27. http://dx.doi.org/10.36348/sjmps.2022.v08i10.017.

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Inflammatory bowel diseases (IBD) are Ulcerative colitis (UC) and Crohn‘s disease (CD). Conventional therapies are inadequate and are associated with several systemic side effects due to lack to localization of active moiety at the inflamed site. Colonic drug targeting is a novel potentially active area of research intended and focused on drug delivery for treating localized disease. Targeted drug delivery to the colon would ensure direct treatment at the disease site, lower dosing and fewer systemic side effects.

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Ikawa, Yasuhiro, Raita Araki, Toshihiro Fujiki, et al. "Highly Elevated IL-18 Is a Reliable Predictor of Progression to Hemophagocytic Syndrome in the Patients with Langerhans Cell Histiocytosis." Blood 124, no. 21 (2014): 2736. http://dx.doi.org/10.1182/blood.v124.21.2736.2736.

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Abstract Introduction: Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of epidermal antigen-presenting cells such as dendritic cells (DCs). Historically, three distinct clinical syndromes have been described: eosinophilic granuloma (EG), Hand-Schuller-Christian disease and Letterer-Siwe disease (LSD). The disease has a broad spectrum of clinical behavior, from a mild self-limited form like EG-type LCH to an aggressive form associated with a high mortality rate like LSD-type LCH. Since one of the lethal complications of LCH is hemophagocytic syndrome (HPS), investigating a

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S Rathee, Vazir, Kumar Mrigank, Devendra S Pawar, Deepak Garg, Syed Aamer, and Swapnil Bala. "Comparison of Efficacy Outcome of Side to Side End to Side Radiocephalic Arteriovenous Fistula in Patients of Chronic Kidney Disease." International Journal of Science and Research (IJSR) 10, no. 4 (2021): 541–44. https://doi.org/10.21275/sr21410190327.

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Manjit, Kaur 1. *. Akanksha Choudhary 1. Prerna Upadhyay 1. Shaina Kujar 1. Dr. Nitan Bharti Gupta 2. "RECENT ADVANCES IN COLON TARGETED DRUG DELIVERY SYSTEM: AN UPDATE." Journal of Pharma Research 8, no. 7 (2019): 486–93. https://doi.org/10.5281/zenodo.3357195.

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<strong><em>ABSTRACT</em></strong> <strong><em>C</em></strong><em>olonic drug delivery has gained interest for the delivery of drug for the treatment of local diseases which allows for treatment of inflammatory bowel disease associated with colon and systemic delivery of therapeutic peptides and proteins and its side effects could be reduced. The drug directly delivered to colon then its treatment is more effective.</em> <em>The colon is often a prospective site for the systemic absorption of a handful of drugs for the treatment of non-colonic conditions. Improved drug delivery systems are ess

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42

Praveen, Kumar Sharma, and Chhyala Devendra. "A LITERATURE REVIEW ON THE SIGNIFICANCE OF NIDAN PANCHAK AYURVEDA." World Journal of Pharmaceutical Science and Research 3, no. 6 (2024): 60–67. https://doi.org/10.5281/zenodo.14252475.

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Ayurveda is a system of medicine that aims to understand and treat diseases and maintain a healthy lifestyle. It is based on the Sanskrit stanza "Swasthasya Swaasthya Rakshanama Aturasya Vikara Prashmanam Cha" and includes three sutras: Hetu (cause), Linga (side effects), and Aushadha (medication). The right diagnosis is crucial for resolving a disease, and Acharya Charaka emphasizes this. In ancient texts, the main methods for diagnosis were Pramana, which helped understand the Dosha, Dushya, and site of Dosha-Dushya Sammurchana. In Ayurveda, there are five methods for analysis: Nidana (cause

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Georgalas, Ilias, Theodore Paraskevopoulos, Chryssanthi Koutsandrea, et al. "Ophthalmic Metastasis of Breast Cancer and Ocular Side Effects from Breast Cancer Treatment and Management: Mini Review." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/574086.

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Breast cancer is one of the most common malignant diseases occurring in women, and its incidence increases over the years. It is the main site of origin in ocular metastatic disease in women, and, due to its hematogenous nature of metastatic spread, it affects mainly the uveal tissue. The purpose of this paper is to summarize the clinical manifestations of the breast cancer ocular metastatic disease, alongside the side effects of the available treatment options for the management and regression of the systematic and ophthalmic disease.

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Ariszandy, Putu Hernanda Krishna, I. Dewa Nyoman Nurweda Putra, and Widiastuti Widiastuti. "Identifikasi Jenis dan Prevalensi Penyakit Karang pada Terumbu Karang di Perairan Pemuteran." Journal of Marine Research and Technology 3, no. 1 (2020): 25. http://dx.doi.org/10.24843/jmrt.2020.v03.i01.p05.

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Coral reef ecosystems play an important role in many aspects of human beings as one third of Indonesian population are living in coastal areas and depend their lives on this ecosystem. However, this ecosystem is threatened by various factors, one of them is coral disease. Increased sea water temperature, sedimentation, and pollutants can increase the growth of pathogenic microorganisms that cause coral disease. The data of coral diseases was collected byqpurposive samplingpmethod which was chosen based on the presence of coral reefs and coastal conditions at each station in a belt transect of

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Buliņa, Inita, and Jūlija Zepa. "Outcomes of Vaccination Against SARS-CoV-2 in Patients with Rheumatic Diseases in Latvia." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 78, no. 1 (2024): 22–28. http://dx.doi.org/10.2478/prolas-2024-0004.

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Abstract The retrospective study for rheumatic disease patients was conducted between 27 December 2020 and 31 August 2021 at Pauls Stradiņš Clinical University Hospital, in the largest centre of Rheumatology in Latvia with the aim of assessing the impact of vaccination against SARS-CoV-2 for rheumatic disease patients. From the hospital’s local medical electronic system, we collected demographic data, disease activity, comorbidities, data regarding vaccines and their side effects for 422 rheumatic disease patients. Most of them, 377 (89.3%), had inflammatory arthritis or a rare rheumatic disea

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Goyal, Arun, P. P. Singh, and Gautam Dash. "Chorda Tympani in Chronic Inflammatory Middle Ear Disease." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (2008): P52—P53. http://dx.doi.org/10.1016/j.otohns.2008.05.170.

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Objective To study the effect of chronic inflammatory middle ear disease on gustatory function of chorda tympani nerve. Methods A prospective study was performed in 2007 on 85 patients of unilateral chronic inflammatory middle ear disease of both cholesteatomatous and noncholesteatomatous type. Gustatory assessment on both sides of the tongue was performed using dry taste strips. Taste strips were made of filter paper soaked in four different taste solutions of four different concentrations each and dried. The taste score is the number of correctly identified taste strips. Results were analyze

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Trompetero, Adriana, Aldemar Gordillo, Mora Carolina del Pilar, Velasquillo María Cristina, and Rosa Helena Bustos Cruz. "Alzheimer’s Disease and Parkinson’s Disease: A Review of Current Treatment Adopting a Nanotechnology Approach." Current Pharmaceutical Design 24, no. 1 (2018): 22–45. http://dx.doi.org/10.2174/1381612823666170828133059.

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Neurodegenerative disorders (NDDs) are characterized by the progressive loss of structure or neuron function, often associated with neuronal death. Treatments for neurodegenerative diseases only address symptoms without having any disease-modifying effect but serious side effects. Currently, there is no effective treatment for NDDs. This is due to the poor flow of drugs to the blood-barrier brain (BBB) which does not allow macromolecules like proteins and peptides to pass through it. Targeted drug delivery to the central nervous system (CNS) for the diagnosis and treatment of NDDs, such as Alz

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Selcuk, Gocmen, Demir Goksemin, Unal Ayse, Altug Filiz, and Cavlak Ugur. "Treatment strategies for patients with advanced stage parkinsons dısease." International Journal of Medical Reviews and Case Reports 3, no. 4 (2018): 144–50. https://doi.org/10.5455/IJMRCR.advanced-stage-parkinson-disease-treatment.

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Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting multiple systems and mainly related to dopaminergic deficiency in the substantia nigra resulting in bradykinesia, rigidity and rest tremor. Pharmacological treatments are very successful in the early stages of the disease, but side effects and motor complications are the main problems as the disease reaches to advanced stage. In advanced PD patients, the most disabling complication of long term L-dopa treatment is the unpredictable swings between "on" state with L-dopa induced dyskinesias and "off" state. We will re

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ABE, Y., T. ROKKAKU, S. OFUCHI, S. TOKUNAGA, K. TAKAHASHI, and H. MORIYA. "Dupuytren’s Disease on the Radial Aspect of the Hand: Report on 135 Hands in Japanese Patients." Journal of Hand Surgery 29, no. 4 (2004): 359–62. http://dx.doi.org/10.1016/j.jhsb.2003.12.007.

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We studied 135 hands in 77 Japanese patients to assess the frequency of radial involvement and its association with recurrence and the Dupuytren’s diathesis. The radial aspect of the hand was affected in 22% of the hands. Diseased cords were observed in ten patients who underwent surgery on the radial aspect of the hand. Longitudinal cords on the radial side of thenar eminence and distal transverse interdigital cords were common. The radial aspect of the hand was the most common site of disease extension, though recurrence never occurred after excision of a radial lesion. Ectopic lesions, bila

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Miller, Jennifer, Michael J. Sweet, Elizabeth Wood, and John Bythell. "Baseline coral disease surveys within three marine parks in Sabah, Borneo." PeerJ 3 (November 3, 2015): e1391. http://dx.doi.org/10.7717/peerj.1391.

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Two of the most significant threats to coral reefs worldwide are bleaching and disease. However, there has been a scarcity of research on coral disease in South-East Asia, despite the high biodiversity and the strong dependence of local communities on the reefs in the region. This study provides baseline data on coral disease frequencies within three national parks in Sabah, Borneo, which exhibit different levels of human impacts and management histories. High mean coral cover (55%) and variable disease frequency (mean 0.25 diseased colonies m−2) were found across the three sites. Highest dise

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