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Relevant bibliographies by topics / SJIA

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Journal articles

Academic literature on the topic 'SJIA'

Author: Grafiati

Published: 14 March 2023

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Journal articles on the topic "SJIA"

1

Ombrello, Michael J., Victoria L. Arthur, Elaine F. Remmers, et al. "Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications." Annals of the Rheumatic Diseases 76, no. 5 (2016): 906–13. http://dx.doi.org/10.1136/annrheumdis-2016-210324.

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ObjectivesJuvenile idiopathic arthritis (JIA) is a heterogeneous group of conditions unified by the presence of chronic childhood arthritis without an identifiable cause. Systemic JIA (sJIA) is a rare form of JIA characterised by systemic inflammation. sJIA is distinguished from other forms of JIA by unique clinical features and treatment responses that are similar to autoinflammatory diseases. However, approximately half of children with sJIA develop destructive, long-standing arthritis that appears similar to other forms of JIA. Using genomic approaches, we sought to gain novel insights into

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2

Kim, Daeun, Jaeseung Song, Sora Lee, Junghyun Jung, and Wonhee Jang. "An Integrative Transcriptomic Analysis of Systemic Juvenile Idiopathic Arthritis for Identifying Potential Genetic Markers and Drug Candidates." International Journal of Molecular Sciences 22, no. 2 (2021): 712. http://dx.doi.org/10.3390/ijms22020712.

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Systemic juvenile idiopathic arthritis (sJIA) is a rare subtype of juvenile idiopathic arthritis, whose clinical features are systemic fever and rash accompanied by painful joints and inflammation. Even though sJIA has been reported to be an autoinflammatory disorder, its exact pathogenesis remains unclear. In this study, we integrated a meta-analysis with a weighted gene co-expression network analysis (WGCNA) using 5 microarray datasets and an RNA sequencing dataset to understand the interconnection of susceptibility genes for sJIA. Using the integrative analysis, we identified a robust sJIA

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3

Ombrello, Michael J., Elaine F. Remmers, Ioanna Tachmazidou, et al. "HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis." Proceedings of the National Academy of Sciences 112, no. 52 (2015): 15970–75. http://dx.doi.org/10.1073/pnas.1520779112.

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Systemic juvenile idiopathic arthritis (sJIA) is an often severe, potentially life-threatening childhood inflammatory disease, the pathophysiology of which is poorly understood. To determine whether genetic variation within the MHC locus on chromosome 6 influences sJIA susceptibility, we performed an association study of 982 children with sJIA and 8,010 healthy control subjects from nine countries. Using meta-analysis of directly observed and imputed SNP genotypes and imputed classic HLA types, we identified the MHC locus as a bona fide susceptibility locus with effects on sJIA risk that trans

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4

Kaleda, M., E. Fedorov, I. Nikishina, et al. "AB1252 RETROSPECTIVE SINGLE CENTER STUDY OF THE PREDICTIVE ROLE OF CERTAIN BIOMARKERS IN MACROPHAGE ACTIVATION SYNDROME RELATED TO SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1736.2–1737. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3328.

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BackgroundSystemic juvenile idiopathic arthritis (sJIA) is a childhood arthritis with signs of autoinflammation and high risk of macrophage activation syndrome (MAS). Immunopathogenesis of sJIA is based on excessive activation of innate immunity, which is characterized by hyperproduction of pro-inflammatory cytokines - interleukin (IL)-1 and IL-18, which play a key role in induction of synthesis of other pro-inflammatory mediators. Macrophage activation mediates the evidence of hyperferritinemia, which stimulates a pathological immune response with the development of MAS. In clinical practice,

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5

Rolfes, Elisabeth, Sae Lim von Stuckrad, and Tilmann Kallinich. "Eine neue Lungenerkrankung bei Kindern mit systemischer JIA/Still-Syndrom." Kinder- und Jugendmedizin 21, no. 05 (2021): 358–63. http://dx.doi.org/10.1055/a-1558-7356.

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ZUSAMMENFASSUNGIm letzten Jahrzehnt hat eine neue Komplikation der systemischen juvenilen Arthritis mehr und mehr Beachtung in Fachkreisen und als „sJIA Lung Disease“ (sJIA-LD) Einzug in die Literatur gefunden. Die Kinder mit sJIA-LD präsentieren sich mit initial oft unspezifischen respiratorischen Symptomen, Hypoxie und Hautausschlag. Ein häufiges eindrückliches erstes Zeichen sind Trommelschlegelfinger mit digitalen Erythemen. Möglicherweise scheint die sJIA-LD gehäuft aufzutreten, wenn Kinder ein junges Alter bei sJIA-Diagnose hatten sowie ein oder mehrere Makrophagen-Aktivierungssyndrome i

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6

Krekhova, E. A., E. I. Alekseeva, and T. M. Dvoryakovskaya. "Predictors of response to therapy with biologicals in children with systemic juvenile idiopathic arthritis." Voprosy praktičeskoj pediatrii 16, no. 1 (2021): 64–78. http://dx.doi.org/10.20953/1817-7646-2021-1-64-78.

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Systemic juvenile idiopathic arthritis (sJIA) is a severe orphan autoimmune disease characterized by fever, polymorphic skin rash, hepatosplenomegaly, serositis, generalized lymphadenopathy, and destructive arthritis. Proinflammatory cytokines, including interleukin-1 (IL-1), IL-6, IL-17, IL-18, and tumor necrosis factor (TNF), play a key role in sJIA pathogenesis. sJIA is refractory to conventional immunosuppressive antirheumatic drugs. Before the development of biologicals, sJIA patients had to receive corticosteroids constantly. The implementation of biologicals, such as tocilizumab (IL-6 i

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7

Vankova, D. D., E. I. Alekseeva, T. M. Dvoryakovskaya, et al. "Activity of systemic juvenile idiopathic arthritis in children immunized with pneumococcal 13-valent conjugate vaccine: prospective cohort study." Voprosy praktičeskoj pediatrii 15, no. 5 (2020): 40–50. http://dx.doi.org/10.20953/1817-7646-2020-5-40-50.

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Evaluation of the safety profile of vaccines in patients with rheumatic diseases requires an assessment of their impact on disease activity. The effect of antipneumococcal vaccination on the activity of systemic juvenile idiopathic arthritis (sJIA) has not been studied so far. Objective. To evaluate the dynamics of sJIA activity after immunization with pneumococcal 13-valent conjugate vaccine (PCV13) of patients receiving biologicals. Patients and methods. This study included patients with sJIA in remission or active disease receiving biologicals during inpatient treatment and vaccinated with

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8

Zhou, Mi, Ruru Guo, Yong-Fei Wang, Wanling Yang, Rongxiu Li, and Liangjing Lu. "Application of Weighted Gene Coexpression Network Analysis to Identify Key Modules and Hub Genes in Systemic Juvenile Idiopathic Arthritis." BioMed Research International 2021 (August 13, 2021): 1–13. http://dx.doi.org/10.1155/2021/9957569.

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Systemic juvenile idiopathic arthritis (sJIA) is a severe autoinflammatory disorder with a still not clearly defined molecular mechanism. To better understand the disease, we used scattered datasets from public domains and performed a weighted gene coexpression network analysis (WGCNA) to identify key modules and hub genes underlying sJIA pathogenesis. Two gene expression datasets, GSE7753 and GSE13501, were used to construct the WGCNA. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were applied to the genes and hub genes in the sJIA modules. Cytoscap

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9

Sun, Juan, Miao Feng, Fengqi Wu, et al. "Plasma miR-26a as a Diagnostic Biomarker Regulates Cytokine Expression in Systemic Juvenile Idiopathic Arthritis." Journal of Rheumatology 43, no. 8 (2016): 1607–14. http://dx.doi.org/10.3899/jrheum.150593.

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Objective.We sought to identify specific microRNA (miRNA) for systemic juvenile idiopathic arthritis (sJIA) and to determine the involvement of these miRNA in regulating the expression of cytokines.Methods.Microarray profiling was performed to identify differentially expressed miRNA in sJIA plasma. Levels of candidate miRNA and mRNA were assessed by real-time PCR, and cytokines were measured by ELISA. Dual-luciferase reporter assay was used to validate the direct interaction between miR-26a and interleukin 6 (IL-6).Results.Forty-eight miRNA were differentially expressed in the plasma of patien

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10

Gohar, Faekah, Angela McArdle, Melissa Jones, et al. "Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis." Annals of the Rheumatic Diseases 78, no. 8 (2019): 1107–13. http://dx.doi.org/10.1136/annrheumdis-2019-215051.

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ObjectivesThe International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis. Recent initiatives to revise current criteria recognise that a lack of arthritis complicates making the diagnosis early, while later a subgroup of patients develops aggressive joint disease. The proposed biphasic model of SJIA also implies a ‘window of opportunity’ to abrogate the development of chronic arthritis. We aimed to identify novel SJIA biomarkers during different disease phases.MethodsChi

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