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Dissertations / Theses on the topic 'Sjögren’s disease'

Author: Grafiati

Published: 31 May 2025

Last updated: 31 July 2025

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1

Bettacchioli, Eléonore. "Identification de signatures biologiques pour la stratification des patients atteints de maladies auto-immunes systémiques." Electronic Thesis or Diss., Brest, 2025. http://www.theses.fr/2025BRES0013.

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Les maladies auto-immunes telles que la maladie de Sjögren (SjD) et le lupus érythémateux systémique (LES) posent des défis majeurs liés à une grande hétérogénéité clinique et biologique. Au travers d’analyses multi-omiques, cette thèse présente des objectifs multiples : (i) Caractériser le profil clinique et biologique des patients atteints de SjD selon leur profil d’auto-anticorps, (ii) Créer un outil en ligne facilitant l'accès et l'interprétation des données de transcriptomique du LES, et (iii) Analyser les interactions cellulaires dans le tissu rénal du LES. Dans la SjD, la stratification

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2

Jazzar, Ahoud Abdulaziz A. "Biomarkers of salivary gland disease in Sjögren's syndrome." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/biomarkers-of-salivary-gland-disease-in-sjoegrens-syndrome(a889fe46-ad28-4403-8099-9668eaa13c1f).html.

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Sjögren’s syndrome (SS) is a systemic, chronic, autoimmune inflammatory disease that affects the exocrine glands. The absence of early diagnostic markers contributes to delays in its diagnosis. Furthermore, SS patients have an increased incidence of lymphoma and there is a need for biomarkers to identify its development. To enable a better understanding of disease activity and progression, the following aims were undertaken; 1. Investigate the potential use of the salivary gland assessment tests (whole flow rates (WFR), parotid flow rates (PFR), clinical oral dryness score (CODS) and ultrasoun

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3

Vasaitis, Lilian. "Lymphoma studies in patients with Sjögren's syndrome." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-320220.

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Patients with primary Sjögren’s syndrome (pSS) are at increased risk of developing malignant lymphoma. The studies in this thesis aim at broadening our understanding of the association between these two conditions. Germinal centre (GC)-like structures were found in minor salivary gland biopsies taken at the time of pSS diagnosis in 25% of 175 studied patients. Lymphoma development was observed in 86% of the GC-positive pSS patients and 14% of the GC-negative patients. GC-like structures in salivary gland biopsies at pSS diagnosis might identify pSS patients at high risk for later lymphoma deve

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Aasarød, Knut. "Renal involvement in inflammatory rheumatic disease : a study of renal disease in Wegener's granulomatosis and in primary Sjögren's syndrome." Doctoral thesis, Norwegian University of Science and Technology, Faculty of Medicine, 2001. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-1471.

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5

Finnsson, Johannes. "Radiological studies of LMNB1-related autosomal dominant leukodystrophy and Marinesco-Sjögren syndrome." Doctoral thesis, Uppsala universitet, Radiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303171.

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There are approximately 6000 to 8000 rare diseases, each with a prevalence of less than 1 / 10 000, but in aggregate affecting 6 to 8% of the population. It is important to evaluate disease development and progression to know the natural course of any disease. This information can be utilized in diagnostics and in assessing effects of therapeutic interventions as they become available. This thesis describes the natural clinical history and evolution of imaging findings of two rare diseases over approximately two decades. Papers I, II and III present clinical, magnetic resonance imaging (MRI),

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6

Li, Baihui. "Autophagie comme cible thérapeutique potentielle pour le syndrome de Sjögren." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ042.

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Le syndrome de Sjögren (SS) est l'une des maladies autoimmunes (MAI) systémiques les plus fréquentes chez l’Homme. Cette maladie est caractérisée par une infiltration lymphocytaire dans les glandes exocrines conduisant à des symptômes dits de « yeux secs » et à la bouche sèche. Il n’existe actuellement aucun traitement curatif pour cette maladie. Le peptide P140 a été démontrée comme un outil thérapeutique efficace chez les patients atteints d'un lupus érythémateux disséminé (LED) et des souris modèles développant un lupus.L'autophagie est une voie intracellulaire conservée qui joue un rôle ce

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7

Soyfoo, Muhammad Shahnawaz. "Contribution to the diagnosis and pathophysiology of Sjögren's syndrome." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209588.

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Le syndrome de Sjögren (SS) est une maladie auto-immunitaire caractérisée par une infiltration lymphocytaire des glandes exocrines menant le plus souvent, à une xérophtalmie et à une xérostomie. La physiopathologie de la maladie est complexe et malgré les progrès realisés, il existe beaucoup de questions à repondre. Classiquement, le syndrome sec qui caractérise la maladie résulterait d’un double processus où dans un premier temps, la glande serait envahie par des cellules lymphoplasmocytaires puis secondairement détruite. Des avancées récentes dans la physiopathologie de la maladie ont démont

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8

Imgenberg-Kreuz, Juliana. "Epigenetic and Gene Expression Signatures in Systemic Inflammatory Autoimmune Diseases." Doctoral thesis, Uppsala universitet, Molekylär medicin, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-310388.

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Autoimmune diseases are clinical manifestations of a loss-of-tolerance of the immune system against the body’s own substances and healthy tissues. Primary Sjögren’s syndrome (pSS) and systemic lupus erythematosus (SLE) are two chronic inflammatory autoimmune diseases characterized by autoantibody production and an activated type I interferon system. Although the precise mechanisms leading to autoimmune processes are not well defined, recent studies suggest that aberrant DNA methylation and gene expression patterns may play a central role in the pathogenesis of these disorders. The aim of this

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9

Niemelä, R. (Raija). "Imaging of salivary glands and assessment of autonomic nervous system function in primary Sjögren's syndrome." Doctoral thesis, University of Oulu, 2004. http://urn.fi/urn:isbn:9514272757.

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Abstract The purpose of the present study was to find reliable non-invasive methods for imaging salivary glands and diagnosing primary Sj?gren's syndrome (SS) and to evaluate autonomic function and central nervous system (CNS) disorders in patients with primary SS. The patient population consisted of consecutive patients with primary SS, who fulfilled the International classification criteria for primary SS, from the Division of Rheumatology, Department of Internal Medicine in Oulu University Hospital. Magnetic resonance (MR) imaging and MR sialography of parotid glands were performed on 27 p

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10

Serrano, Érica Vieira. "Adaptação transcultural do Eular Sjögren s Syndrome Disease Activity Index(ESSDAI) para a Língua Portuguesa Brasileira." Universidade Federal do Espírito Santo, 2012. http://repositorio.ufes.br/handle/10/5494.

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Made available in DSpace on 2016-08-30T10:50:13Z (GMT). No. of bitstreams: 1 tese_6197_2011_Erica Serrano.pdf: 772975 bytes, checksum: d76dc5832c1174a3d28b433ca9851c73 (MD5) Previous issue date: 2012-11-05<br>Introdução: O EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) é um índice composto para avaliar a atividade sistêmica da Síndrome de Sjögren primária (SSP), criado em 2009 na língua inglesa, ainda sem adaptação cultural para a língua portuguesa. Objetivo: Realizar a adaptação transcultural do ESSDAI para a língua portuguesa brasileira. Método: Estudo observacional transversal d

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11

Serrano, érica Vieira. "Adaptação transcultural do EULAR Sjögren/ s syndrome disease activity index (ESSDAI) para a língua portuguesa brasileira." Universidade Federal do Espírito Santo, 2012. http://repositorio.ufes.br/handle/10/5677.

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Made available in DSpace on 2016-12-23T13:46:57Z (GMT). No. of bitstreams: 1 Erica Vieira Serrano.pdf: 1290263 bytes, checksum: 97d4b3362a8eb6c3ab6057f6d6c97b1b (MD5) Previous issue date: 2012-11-05<br>Introduction: The EULAR Sjögren s Syndrome Disease Activity Index (ESSDAI) is a composite index to assess systemic activity of primary Sjögren s Syndrome (SSP) created in 2009 and it does not have any cultural adaptation to Portuguese language. Objective: To perform the cultural adaptation of ESSDAI for Brazilian Portuguese. Methods: Cross-sectional observational study with patients with SSP a

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12

Lidén, Maria. "Gut Mucosal Reactivity to Gluten and Cow´s Milk Protein in Rheumatic Diseases." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110297.

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This thesis comprised patients with chronic rheumatic diseases. The studies aimed to elucidate food sensitivity by measuring mucosal inflammatory reactivity and thereby a possible link between the gut and joints. In all the studies, the mucosal path technique was used to evaluate the rectal mucosal response to rectal challenge with gluten and/or cow’s milk protein (CM). In some patients with primary Sjögren’s syndrome (pSS) and the genetic susceptibility genes HLA DQ2, mucosal reactivity measured with nitric oxide (NO) was found after rectal gluten challenge without detectable serum antibodies

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13

Москаленко, Павло Олександрович, Павел Александрович Москаленко, Pavlo Oleksandrovych Moskalenko, et al. "Application of saliva crystalloscopy methods in the diagnosis of malignant tumours of salivary glands and Sjögren disease." Thesis, Published by IASHE London, 2015. http://essuir.sumdu.edu.ua/handle/123456789/44378.

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A high informational content of saliva crystalloscopy in the diagnosis of salivary glands tumours was proven; typical symptoms of Sjögren disease and malignant tumours of the salivary glands were found on the ground of the analysis of the presented research method.

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14

Akasbi, Montalvo Miriam. "Caracterización clínicoevolutiva de la afección neurológica del síndrome de Sjögren." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/134134.

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Los artículos que se han incluido en esta Tesis Doctoral se centran en el estudio y caracterización de la afección neurológica que presentan los pacientes con Síndrome de Sjögren (SS) primario, incluyendo la evaluación tanto de la afección del sistema nervioso central como del sistema nervioso periférico en una cohorte de pacientes que ha sido estudiada de forma estandarizada y prospectiva en el Servicio de Enfermedades Autoinmunes del Hospital Clínic de Barcelona desde principios de los años 90. En los artículos se han analizado también aspectos específicos que pudieran influir en la prevalen

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15

Killian, Martin. "Nouvelles immunothérapies dans le traitement du syndrome de Sjögren et autres maladies interféron-dépendantes." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSES051.

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Durant mon travail de thèse, je me suis particulièrement intéressé au lien entre les maladies auto-immunes et le système des interférons (IFN). Ces cytokines sont bien connues pour leur rôle dans la lutte antivirale, mais leurs effets dépassent largement ce cadre, avec une implication maintenant bien documentée dans la physiopathologie de nombreuses maladies dysimmunes comme le lupus érythémateux systémique (LES), le syndrome de Sjögren (SjS), les myosites ou encore la sclérodermie systémique, en particulier concernant les IFNs de type 1. C’est donc assez logiquement que nous nous sommes arrêt

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16

Samad-Zadeh, Arman. "The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjögren-like disease." Thesis, Boston University, 2014. https://hdl.handle.net/2144/31300.

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Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2014 (Department of Endodontics).<br>Includes bibliographic references: leaves 41-49.<br>Sjogren's syndrome (SS) is a chronic, multisystem inflammatory disorder of multifactorial etiology resulting in loss of secretory function in the exocrine glands including salivary and lacrimal. Even though the pathophysiology progression of SS has been subject to great amount of research, the roles of different mechanisms remain inconclusive. The main dogma is that immune system pathology drives SS; however, there is no straight

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17

Lövgren, Tanja. "Endogenous Type I Interferon Inducers in Systemic Autoimmune Diseases." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7181.

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<p>Patients with systemic lupus erythematosus (SLE) have elevated levels of interferon (IFN)-α in blood and IFN-α-producing cells in tissues. In the present thesis, we investigate the mechanisms behind the upregulated IFN-α-production in SLE and also show that the IFN-α system is activated in primary Sjögren’s syndrome (pSS), with IFN-α-producing cells in the major affected organ, the salivary glands. The IFN-α is a type I IFN, a family of cytokines counteracting especially viral infections, by acting directly on infected cells, and via many immunomodulatory effects. The latter may also contri

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18

Florezi, Giovanna Piacenza. "Xerostomia na doença do enxerto contra o hospedeiro: análise das alterações glandulares e dos níveis salivares das citocinas envolvidas nas respostas Imunológicas Th17." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/23/23139/tde-27112017-131058/.

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A doença do enxerto contra o hospedeiro (DECH) é uma das maiores causas de mortalidade e morbidade pós-transplante de células-tronco hematopoiéticas. A DECH, em sua manifestação crônica (DECHc), ainda não tem sua fisiopatologia totalmente esclarecida; entretanto, o envolvimento do sistema imunológico, por meio de respostas imunes inatas e adaptativas é bem estabelecido na literatura. A DECHc afeta múltiplos órgãos, incluindo as glândulas salivares, o que tem, como causa imediata, a xerostomia. Essas alterações são largamente desconhecidas e sub-relatadas. Assim, esse estudo indagou se o sintom

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19

Augusto, Kristopherson Lustosa. "Estudo da síndrome metabólica e do perfil de adipocitocinas na síndrome de Sjögren primária: relevância clínica e correlações com citocinas inflamatórias." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5164/tde-05102016-124645/.

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A Síndrome Metabólica (SM) tem sido descrita nas doenças autoimunes. No entanto, existem poucos dados na literatura sobre a síndrome metabólica e o perfil de adipocitocinas na síndrome de Sjögren primária (SSp). Setenta e um pacientes do sexo feminino com SSp com idades entre 18-65 anos (Critérios do Consenso Euramericano, 2002) e 71 mulheres saudáveis pareadas por idade e raça foram incluídas neste estudo caso-controle. Os dados clínicos foram coletados por meio de um protocolo padronizado. Os níveis sanguíneos de glicose, colesterol total, LDL-colesterol (LDL-C), HDL-colesterol (HDL-C), trig

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20

Fernandes, Juliana Dumêt. "Estudo comparativo das alterações das glândulas salivares menores em doentes com queixa de xerostomia na síndrome de Sjögren e no lúpus eritematoso." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-08032010-111900/.

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INTRODUÇÃO: Xerostomia é um sintoma comum relacionado a diversas doenças e faz parte da complexa exocrinopatia que afeta glândulas salivares na síndrome de Sjögren (SS). Sintomas similares são encontrados em outras doenças crônicas auto-imunes, incluindo o lúpus eritematoso (LE). O principal achado histopatológico na SS é a infiltração linfocitária que destrói o epitélio ductal levando à atrofia glandular. No LE, alterações das glândulas salivares são raramente relatadas, e tem sido comumente associadas com a SS pela maioria dos autores. OBJETIVOS: Analisar e comparar as alterações histopatoló

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21

Uddenfeldt, Per. "Primary biliary cirrhosis : an epidemiological and clinical study based on patients from northern Sweden." Doctoral thesis, Umeå universitet, Medicin, 1990. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96911.

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Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease, which primarily affects middle-aged women. The liver histology is characterized by inflammation and destruction of the intrahepatic bile ducts as well as a high frequency of granuloma. Although the etiology is unknown, the occurrence of associated multiorganic abnormalities such as Sjogren's syndrome, scleroderma, rheumatic disorders and thyroid gland diseases have been cited as evidence favouring an autoimmune background. Addison and Gull in 1851 described the first patient with jaundice and xanthomatosis. PBC was first m

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22

Candeias, Rafaela Nunes Infante. "Síndrome de Sjögren: impacto na cavidade oral." Master's thesis, 2020. http://hdl.handle.net/10284/9257.

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Tópico abordado: Nesta tese aborda-se a Síndrome de Sjögren, mais especificamente o seu impacto na cavidade oral. Objetivo: Este trabalho teve como objetivo a realização de uma revisão bibliográfica da literatura, abordando a síndrome de Sjögren, uma patologia autoimune que afeta tipicamente o tecido glandular salivar. No presente trabalho, pretende-se perceber o papel da genética, e descreve-se os sinais clínicos que poderão alertar os médicos dentistas para a presença de um paciente com Síndrome de Sjögren, isto é, expor as manifestações orais associadas, sendo a mais impactante a Xerostomi

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23

Martins, Nádia Priscila Costa. "Síndrome de Sjögren perfil epidemiológico potencial valor de diagnóstico salivar : case report." Master's thesis, 2014. http://hdl.handle.net/10400.14/15286.

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INTRODUÇÃO: Síndrome de Sjögren é uma doença reumática sistémica autoimune, caracterizada por inflamação linfocitária das glândulas exócrinas, resultando na sua hipofunção. Pode-se distinguir Síndrome de Sjögren primária de secundária, sendo que a primeira atinge as glândulas exócrinas e a segunda, está associada a outras doenças autoimunes, tornando o seu diagnóstico um desafio, argumento válido para considerar o diagnóstico salivar como meio complementar de diagnóstico. OBJETIVOS: Identificar o perfil epidemiológico do Síndrome de Sjögren e enfatizar a importância do diagnóstico através da p

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24

Ribeiro, Francisco de Sousa Sebastião Alexandre. "Anti-Ro/SSA and the development of hematological malignancy in systemic autoimmune diseases." Master's thesis, 2021. http://hdl.handle.net/10451/52026.

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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2021<br>Os auto-anticorpos estão associados a um número considerável doenças autoimunes. O anticorpo anti-Ro/SSA faz parte deste grupo vasto de anticorpos, podendo encontrar-se em doentes com Síndrome de Sjögren (SS) e Lupus Eritematoso Sistémico (LES), entre outros. O anticorpo anti-Ro tem como alvo o antigénio Ro que se compõe de duas proteínas diferentes, Ro60 e Ro52. Tem sido amplamente reconhecido na literatura que doentes com patologia autoimune como LES e SS têm um risco acrescido d

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