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Journal articles on the topic 'Sjögren’s disease'

Author: Grafiati

Published: 31 May 2025

Last updated: 31 July 2025

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1

Gunawan, Giovanny Azalia, Adinda Ayu Dyah Rahadina, and Budi Prasetyo. "Comprehensive management of pregnant woman with Sjögren’s syndrome." Majalah Obstetri & Ginekologi 30, no. 3 (2022): 134–38. http://dx.doi.org/10.20473/mog.v30i32022.134-138.

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HIGHLIGHTS 1. Sjögren’s syndrome is a chronic autoimmune disease that attacks the exocrine glands, especially lacrimal and salivary glands. 2. Comprehensive management of pregnant women with Sjögren’s syndrome was described.3. Clinical and laboratory examination, risk assessment and also preconception counseling before planning pregnancy are needed by women with Sjögren’s syndrome. ABSTRACT Objective: To illustrate the comprehensive management of pregnant women with Sjögren syndrome. Case Report: A 24 years old women came to Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, due to Sj

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Nalbant, Merve, Gamze Akbaş, and Yunus Özcan. "Panniculitis; A Rare Cutaneous Mafestation of Sjögren’s Syndrome." Medical Science and Discovery 10, no. 10 (2023): 942–44. http://dx.doi.org/10.36472/msd.v10i10.1087.

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Objective: Panniculitis, an inflammatory disorder primarily affecting subcutaneous adipose tissue, is frequently associated with inflammatory rheumatic diseases. Panniculitis is an uncommon cutaneous manifestation of Sjögren's syndrome (SS), an autoimmune disease primarily known for causing dry eyes and mouth. Case: We report the case of a 56-year-old female initially diagnosed with rheumatoid arthritis, who later met the 2016 ACR-EULAR criteria for primary Sjögren’s syndrome. Following several treatments, she developed nodular lesions in the interscapular area, which were later diagnosed as s

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Ghafoor, M. "Sjögren’s Before Sjögren: Did Henrik Sjögren (1899–1986) Really Discover Sjögren’s Disease?" Journal of Maxillofacial and Oral Surgery 11, no. 3 (2011): 373–74. http://dx.doi.org/10.1007/s12663-011-0303-0.

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4

Heros Aureliano Antunes da Silva Maia, Gabriela Afonso Pereira, José César Batista Filho, and Viviane Machicado Cavalcante. "Síndrome de Sjögren: um Diagnóstico Diferencial de Polirradiculopatia Desmielinizante Inflamatória Crônica." Revista Científica Hospital Santa Izabel 8, no. 1 (2024): 34–39. http://dx.doi.org/10.35753/rchsi.v8i1.513.

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A Síndrome de Sjögren é uma doença autoimune caracterizada pelo acometimento das glândulas exócrinas e está relacionada à síndrome seca e diversas manifestações sistêmicas, dentre elas alterações neurológicas. Este trabalho tem como objetivo relatar o caso de um paciente com história de polineuropatia crônica, cuja investigação permitiu identificar achados compatíveis com o diagnóstico de Síndrome de Sjögren.Palavras-chave: Síndrome de Sjögren; Polirradiculoneuropatia Desmielinizante Inflamatória Crônica; Pulsoterapia. Sjögren’s Syndrome is na autoimmune disease characterized by involvement of

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5

Javed, A., R. Balabanov, BGW Arnason, et al. "Minor salivary gland inflammation in Devic’s disease and longitudinally extensive myelitis." Multiple Sclerosis Journal 14, no. 6 (2008): 809–14. http://dx.doi.org/10.1177/1352458508088941.

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Devic’s disease is often considered as a variant of multiple sclerosis (MS). However, evidence suggests that Devic’s disease may be distinct from MS. Devic’s disease can coexist with connective tissue diseases, particularly Sjögren’s disease, but this association is rare with MS. Diagnosis of Sjögren’s disease in patients with neurological symptoms is often difficult. During early stages of Sjögren’s disease, patients may not fulfill all criteria for Sjögren’s disease. A high percentage of patients with Sjögren’s disease have inflammatory infiltrates in minor salivary glands, and this may be a

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6

Okawa, Yuko, and Kenji Ihara. "Sensorineural Hearing Loss in Sjögren’s Syndrome." International Journal of Molecular Sciences 23, no. 19 (2022): 11181. http://dx.doi.org/10.3390/ijms231911181.

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Sjögren’s syndrome is a chronic autoimmune disease characterized by systemic dysfunction of exocrine glands, mainly the salivary and lachrymal glands. Sjögren’s syndrome consists of two forms: primary Sjögren’s syndrome, which is characterized by dry eyes and dry mouth without autoimmune diseases; and secondary Sjögren’s syndrome, which is characterized by symptoms associated with other autoimmune diseases, such as systemic lupus erythematosus. Disease severities vary considerably from mild glandular dryness to severe glandular involvement with numerous extraglandular and systemic features. Se

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Gennari, Juliana D’Agostino, and Louise d’Abadia Morais. "Síndrome de Sjögren: ESSDAI, fluxo salivar, escore oftalmológico e olho seco." Revista Paulista de Reumatologia, no. 2022 jan-mar;21(1) (March 31, 2022): 35–47. http://dx.doi.org/10.46833/reumatologiasp.2022.21.1.35-47.

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A síndrome de Sjögren primária (SSp) é uma doença inflamatória e crônica que pode apresentar manifestações glandulares e sistêmicas (presentes entre 20% e 40% dos casos). Para melhor avaliação dos pacientes com essa doença, métricas que avaliam essas manifestações podem ser utilizadas, dentre elas temos o EULAR Sjögren’s syndrome patient report index (ESSPRI), que avalia sintomas de secura, fadiga e dor articular; o EULAR Sjögren’s syndrome disease activity index (ESSDAI), que avalia atividade sistêmica da doença, resposta ao tratamento e prognóstico; já os índices de dano são representados pe

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8

Islam, Asif, Fatima Khurshid, Muhammad Ahmad Khan, Muhammad Yaser Imran, Samara Siddique, and Tooba Fatima. "An Intriguing Combination: Sjogren Syndrome Coexisting with Hodgkin Lymphoma." International Journal of Advanced Multidisciplinary Research and Studies 4, no. 1 (2024): 934–37. http://dx.doi.org/10.62225/2583049x.2024.4.1.2315.

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While Hodgkin's lymphoma is a lymphoid malignancy, Sjögren’s syndrome is an autoimmune disorder marked by exocrine gland inflammation. Sjögren's syndrome (SS) is a chronic autoimmune condition marked by lymphocytic infiltration of the exocrine glands, primarily the salivary and lachrymal glands, which typically manifests as xerostomia and xerophthalmia. Lymphoma is the most dreaded of these systemic sequelae, which are present in about 50% of individuals with primary SS. These neoplasias are mostly non-Hodgkin and arise from B cells. It is unusual for these two diseases to coexist, and the und

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Mlynáriková, V., D. Mičeková, J. Rovenský, and E. Šteňová. "Sjögren’s syndrome." Acta Facultatis Pharmaceuticae Universitatis Comenianae 62, s11 (2015): 8–14. http://dx.doi.org/10.1515/afpuc-2015-0019.

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Abstract Sjögren’s syndrome is a slowly progressive, inflammatory autoimmune disease primarily affecting exocrine glands. Lymphocytic infiltrates replace functional epithelium and lead to decreased exocrine secretion of salivary and lacrimal glands - xerocrinopathy. Glands of intestinal system and pulmonary tract, skin and vaginal mucosa may also be affected. The most common extraglandular manifestations of primary Sjögren’s syndrome include skin vasculitis, Raynaud’s phenomenon, functional renal abnormalities, neuropathy and arthritis symptoms. This disorder may appear separately as a primary

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10

Mieliauskaitė, Diana, and Vilius Kontenis. "Sjögren’s Disease and Gastroesophageal Reflux Disease: What Is Their Evidence-Based Link?" Medicina 60, no. 11 (2024): 1894. http://dx.doi.org/10.3390/medicina60111894.

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Sjögren’s disease (SjD), or primary Sjögren’s syndrome (pSS), is a heterogeneous chronic autoimmune disorder with multiple clinical manifestations that can develop into non-Hodgkin’s lymphoma in mucosa-associated lymphoid tissue. SjD is one of the autoimmune diseases with the maximum delayed diagnosis due to its insidious onset, heterogeneous clinical features and varied course. It is increasingly recognized that extraglandular manifestations represent a clinical challenge for patients with SjD. The European League Against Rheumatism (EULAR) Sjögren’s Syndrome (SS) Disease Activity Index (ESSD

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11

Melissaropoulos, Konstantinos, Dimitrios Bogdanos, Theodoros Dimitroulas, Lazaros I. Sakkas, George D. Kitas, and Dimitrios Daoussis. "Primary Sjögren’s Syndrome and Cardiovascular Disease." Current Vascular Pharmacology 18, no. 5 (2020): 447–54. http://dx.doi.org/10.2174/1570161118666200129125320.

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Sjögren’s syndrome is a rheumatic autoimmune disease that primarily affects middle-aged women and runs a slowly progressing course with sicca symptoms being the prevalent manifestation. Premature atherosclerosis and increased cardiovascular (CV) morbidity and mortality are frequently encountered in rheumatic diseases characterized by significant systemic inflammation, such as the inflammatory arthritides, systemic vasculitides and systemic lupus erythematosus. In the same context, chronic inflammation and immune aberrations underlying Sjögren’s syndrome are also reported to be associated with

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12

Aleksandrowicz, Jakub, Martyna Zielińska, Natalia Zarankiewicz, et al. "Ranula as an early symptom of Sjögren’s syndrome." Journal of Education, Health and Sport 12, no. 9 (2022): 11–19. http://dx.doi.org/10.12775/jehs.2022.12.09.001.

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Introduction and purpose:  Sjögren's syndrome is an autoimmune disease affecting exocrine glands, mainly salivary glands. A ranula is a type of retention cyst associated with salivary extravasation that develops within the large salivary glands. The most common reason of developing ranula is trauma of bottom of the oral cavity. Damaging the sublingual gland, due to changes in Sjögren’s syndrome, may lead to the development of ranula. The aim of this review is to analyze the possible impact of ranulas on early diagnosis of Sjögren's syndrome. Material and method: This review w

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13

Baer, Alan N., and Katherine M. Hammitt. "Sjögren’s Disease, Not Syndrome." Arthritis & Rheumatology 73, no. 7 (2021): 1347–48. http://dx.doi.org/10.1002/art.41676.

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14

Mathews, S. A., B. T. Kurien, and R. H. Scofield. "Oral Manifestations of Sjögren’s Syndrome." Journal of Dental Research 87, no. 4 (2008): 308–18. http://dx.doi.org/10.1177/154405910808700411.

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Sjögren’s syndrome is a common autoimmune rheumatic disease. The most common symptoms of Sjögren’s syndrome are extreme tiredness, along with dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia). Saliva plays an essential role in numerous functions of the mouth. Xerostomia can be caused by medications, chronic diseases like Sjögren’s syndrome, and medical treatments, such as radiation therapy and bone marrow transplant. Xerostomia can eventually lead to difficulty in swallowing, severe and progressive tooth decay, or oral infections. Despite having excellent oral hygiene, individua

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Azizi, Mounia, Ali El Khand, Rabiaa Bounabe, et al. "Thrombotic Thrombocytopenic Purpura Complicating Secondary Sjögren's Syndrome: A Rare and Serious Association from Africa." Saudi Journal of Medical and Pharmaceutical Sciences 10, no. 01 (2024): 22–25. http://dx.doi.org/10.36348/sjmps.2024.v10i01.004.

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Thrombotic Thrombocytopenic Purpura is a potentially fatal disease that can be life-threatening. The association with Sjogren’s syndrome is rare entity that deserves special attention. To this end, we report the case of a Thrombotic thrombocytopenic purpura complicating secondary Sjögren's syndrome. This is a 49-year-old patient with a history of pure nephrotic syndrome with minimal glomerular lesions (LGM), who developed Sjögren's syndrome two years later. The diagnosis of Sjögren's syndrome was retained with an etiological investigation suggesting SS secondary to SLE systemic lupus erythemat

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16

Fadel, Daddi, and Melissa Barnett. "Ocular Surface Disease in Sjögren's Syndrome: Management in a Scleral Lens Clinical Practice." Journal of Contact lens Research and Science 4, no. 1 (2020): e12-e22. http://dx.doi.org/10.22374/jclrs.v4i1.36.

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Sjögren’s syndrome is a chronic, autoimmune, systemic disease characterized by lymphocytic infiltration and malfunction of the exocrine glands, primarily the lacrimal and salivary glands, resulting in predominant symptoms of dry eye and dry mouth. Sjögren’s syndrome is a highly prevalent condition and is one of the most common systemic, rheumatic, autoimmune diseases, affecting up to 1.4% of adults in the United States, second only to rheumatoid arthritis in its prevalence in North America. Primary Sjögren’s syndrome has shown to affect patients’ health-related quality-of-life due to dryness,

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Bruno, Dario, Barbara Tolusso, Gianmarco Lugli, et al. "B-Cell Activation Biomarkers in Salivary Glands Are Related to Lymphomagenesis in Primary Sjögren’s Disease: A Pilot Monocentric Exploratory Study." International Journal of Molecular Sciences 25, no. 6 (2024): 3259. http://dx.doi.org/10.3390/ijms25063259.

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Primary Sjögren’s disease is primarily driven by B-cell activation and is associated with a high risk of developing non-Hodgkin’s lymphoma (NHL). Over the last few decades, microRNA-155 (miR-155) has arisen as a key regulator of B-cells. Nevertheless, its role in primary Sjögren’s disease remains elusive. Thus, the purpose of this study was (i) to explore miR-155, B-cell activating factor (BAFF)-receptor (BAFF-R), and Interleukin 6 receptor (IL-6R) expression in the labial salivary glands (LSG) of patients with primary Sjögren’s disease, aiming to identify potential B-cell activation biomarker

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18

Holdgate, Nicholas, and E. Wiliam St.Clair. "Recent advances in primary Sjogren's syndrome." F1000Research 5 (June 17, 2016): 1412. http://dx.doi.org/10.12688/f1000research.8352.1.

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Primary Sjögren’s syndrome, a chronic inflammatory process, is among the most commonly occurring rheumatologic diseases. The clinical hallmark of this disease is exocrine gland dysfunction, resulting predominately in dry eyes and dry mouth. However, the disease often extends beyond the exocrine glands to seriously affect other organs systems, such as the lungs, kidneys, and nervous system. Moreover, patients with primary Sjögren’s syndrome develop non-Hodgkin’s B cell lymphoma at a substantially higher rate than the general population. New research has improved our understanding of disease mec

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Yang, Huijia, Xiaozhong Jing, Jinhua Yan, and Dihui Ma. "Sjögren’s syndrome with rapidly progressive motor neuron disease: a case report." Journal of International Medical Research 48, no. 11 (2020): 030006052097446. http://dx.doi.org/10.1177/0300060520974465.

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Sjögren’s syndrome is an autoimmune disease that can affect multiple systems. Sjögren’s syndrome with motor neuron disease is rarely reported. Herein, we describe a patient with rapidly progressive motor neuron disease secondary to Sjögren’s syndrome. A 42-year-old woman was admitted to our hospital with a 2-month history of progressive limb weakness. Neurological assessment revealed fasciculation in the lower limbs and amyotrophy in the bilateral supraspinatus, interosseous, and thenar muscles. Serological examination and labial gland biopsy revealed Sjögren’s syndrome. In addition, electromy

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20

Gheorghe, Dorin Nicolae, Dora Maria Popescu, Stefan Cristian Dinescu, Margarita Silaghi, Petra Surlin, and Paulina Lucia Ciurea. "Association between Sjögren’s Syndrome and Periodontitis: Epidemiological, Fundamental and Clinical Data: A Systematic Review." Diagnostics 13, no. 8 (2023): 1401. http://dx.doi.org/10.3390/diagnostics13081401.

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In recent decades, researchers have investigated the bidirectional links between periodontal disease and systemic diseases, and the results have allowed the development of the concept of periodontal medicine. This concept incorporates and analyzes the mutually influential interactions that can occur between periodontitis and systemic diseases such as diabetes mellitus or cardiovascular diseases. Sjögren’s syndrome (SS) is a chronic autoimmune disorder that targets the exocrine glands of the body, such as the lacrimal and salivary glands. The amount of saliva produced may gradually decrease wit

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Al-Haidose, Amal, Sondoss Hassan, Mahmoud Elhassan, et al. "Role of ncRNAs in the Pathogenesis of Sjögren’s Syndrome." Biomedicines 12, no. 7 (2024): 1540. http://dx.doi.org/10.3390/biomedicines12071540.

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Sjögren’s syndrome is a multisystemic autoimmune disease that mainly affects the exocrine glands, causing dryness of the eyes and the mouth as the principal symptoms. Non-coding RNAs (ncRNAs), once regarded as genomic “junk”, are now appreciated as important molecular regulators of gene expression, not least in Sjögren’s syndrome and other autoimmune diseases. Here we review research into the causative roles of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) on immunological responses, inflammation, and salivary gland epithelial cell function in Sjögren’s syndr

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Wu, Kevin Y., Merve Kulbay, Cristina Tanasescu, Belinda Jiao, Bich H. Nguyen, and Simon D. Tran. "An Overview of the Dry Eye Disease in Sjögren’s Syndrome Using Our Current Molecular Understanding." International Journal of Molecular Sciences 24, no. 2 (2023): 1580. http://dx.doi.org/10.3390/ijms24021580.

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Sjögren’s syndrome is a chronic and insidious auto-immune disease characterized by lymphocyte infiltration of exocrine glands. The patients typically present with ocular surface diseases related to dry eye and other systemic manifestations. However, due to the high prevalence of dry eye disease and the lack of objective and clinically reliable diagnostic tools, discriminating Sjögren’s syndrome dry eye (SSDE) from non-Sjögren’s syndrome dry eye (NSSDE) remains a challenge for clinicians. Diagnosing SS is important to improve the quality of life of patients through timely referral for systemic

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McCoy, Sara S., and Nathan Sandbo. "Sjögren’s Syndrome-Associated Lung Disease." Clinical Pulmonary Medicine 24, no. 6 (2017): 232–38. http://dx.doi.org/10.1097/cpm.0000000000000230.

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Jara, Luis J., Carmen Navarro, María del Pilar Brito-Zerón, Mario García-Carrasco, Ricardo O. Escárcega, and Manuel Ramos-Casals. "Thyroid disease in Sjögren’s syndrome." Clinical Rheumatology 26, no. 10 (2007): 1601–6. http://dx.doi.org/10.1007/s10067-007-0638-6.

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25

Koszarny, Arkadiusz, Anna Górak, and Maria Majdan. "LATE-ONSET SJÖGREN’S SYNDROM." Wiadomości Lekarskie 72, no. 9 (2019): 1687–90. http://dx.doi.org/10.36740/wlek201909115.

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Sjögren’s syndrome is a systemic autoimmune disease characterized by exocrine glands damage, resulting in the development of dry eyes and dry mouth, as well as extraglandular manifestation. It usually starts between the ages of 30 and 50. Late-onset Sjögren’s syndrome should be considered as a disease that appears after age 65, but the literature also reports of the age 50, 60, or even 70. The prevalence of late-onset Sjögren’s syndrome is estimated about 20%. The course of late-onset Sjögren’s syndrome may differ when compared with patients with a younger onset. Lack of sicca symptoms and mar

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Caraba, Alexandru, Stela Iurciuc, Mihaela Nicolin, and Mircea Iurciuc. "Endothelial Dysfunction in Primary Sjögren’s Syndrome: Correlation with Serum Biomarkers of Disease Activity." International Journal of Molecular Sciences 24, no. 18 (2023): 13918. http://dx.doi.org/10.3390/ijms241813918.

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To assess the relationship between endothelial dysfunction and serum cytokines, anti-SSA and anti-SSB antibodies, beta-2 microglobulin levels, focus score and EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI) in primary Sjögren’s syndrome (pSS) patients. The study included 90 patients with pSS and 45 healthy subjects, matched for age and gender, as controls. Serum beta-2 microglobulin, total cholesterol, HDL-cholesterol, triglycerides, TNF-α, and IL-6 were analyzed in both the groups. Patients with pSS were also tested for antinuclear antibodies, anti-SAA (anti-Sjögren’s syndrome-relate

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Seeliger, Tabea, Marten A. Gehlhaar, Irene Oluwatoba-Popoola, et al. "Trigeminal Nerve Affection in Patients with Neuro-Sjögren Detected by Corneal Confocal Microscopy." Journal of Clinical Medicine 11, no. 15 (2022): 4484. http://dx.doi.org/10.3390/jcm11154484.

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Background: Patients with Sjögren’s syndrome and polyneuropathy more frequently develop cranial nerve affection when compared to patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We therefore aimed to analyze trigeminal corneal nerve fibre characteristics in both patient groups. Methods: A total of 26 patients with Sjögren’s syndrome associated neuropathy and 29 patients with CIDP were recruited at our university hospital and compared to 6 healthy controls. Dry eye symptoms and signs were assessed via clinical examination and the Ocular Disease Surface Index questionnaire

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Leverenz, David L., and E. William St. Clair. "Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome." F1000Research 8 (August 29, 2019): 1532. http://dx.doi.org/10.12688/f1000research.19842.1.

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Primary Sjögren’s syndrome is a chronic autoimmune disease characterized by salivary and lacrimal gland dysfunction, leading to substantial morbidity and reduced quality of life. Many patients with primary Sjögren’s syndrome also have extraglandular systemic complications, some of which can be organ- or life-threatening. Over the last decade, numerous targeted immunomodulatory therapies for primary Sjögren’s syndrome have failed to show a benefit in clinical trials, and as yet no disease-modifying therapy has been approved for this disease. Herein, we provide an updated review of the clinical

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Pellegrini, Matteo, Federica Pulicari, Elisabetta Kuhn, Andrea Scribante, and Francesco Spadari. "Minor Salivary Gland Surgery and Histopathological Scoring System: A Systematic Review." International Journal of Clinical Practice 2022 (October 11, 2022): 1–12. http://dx.doi.org/10.1155/2022/7437321.

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Sjögren’s syndrome is a systemic autoimmune disease characterized by chronic inflammation of the exocrine glands with an associated functional deficit. The clinical picture is characterized by symptoms such as dry eyes (xerophthalmia) and dry mouth (xerostomia). The disease is defined as primary if no other autoimmune diseases are associated, otherwise, it is defined as secondary. A systematic review was made using the databases PubMed (MEDLINE), Scopus, and keywords “biopsy,” “classification,” “clinical pathology,” “salivary glands,” and “Sjogren’s syndrome.” The diagnosis of Sjögren’s syndro

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Kapoor, Shavika, Sangeeta Shah, and Mrinalini Mitra. "A rare case of Sjögren’s syndrome in pregnancy and its perinatal outcome- Fetal congenital heart block." Indian Journal of Case Reports 11, no. 1 (2025): 11–13. https://doi.org/10.32677/ijcr.v11i1.4751.

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Sjögren’s syndrome is an autoimmune disease that commonly affects women after the fourth decade of life. Management of pregnancy in women with Sjögren’s syndrome poses unique challenges due to potential maternal and fetal complications. Children born to women with Sjögren’s syndrome can have a higher incidence of prematurity, low birth weight, hypoxic-ischemic encephalopathy, and congenital heart block. We describe the case of 24-year-old primi at 36 weeks of gestation with Sjögren’s syndrome and hypothyroidism, resulting in congenital heart block in the fetus. In this case report, we will dis

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Pastva, Ondřej, and Kerstin Klein. "Long Non-Coding RNAs in Sjögren’s Disease." International Journal of Molecular Sciences 25, no. 10 (2024): 5162. http://dx.doi.org/10.3390/ijms25105162.

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Sjögren’s disease (SjD) is a heterogeneous autoimmune disease characterized by severe dryness of mucosal surfaces, particularly the mouth and eyes; fatigue; and chronic pain. Chronic inflammation of the salivary and lacrimal glands, auto-antibody formation, and extra-glandular manifestations occur in subsets of patients with SjD. An aberrant expression of long, non-coding RNAs (lncRNAs) has been described in many autoimmune diseases, including SjD. Here, we review the current literature on lncRNAs in SjD and their role in regulating X chromosome inactivation, immune modulatory functions, and t

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Kramer, Daniel, and Ross Summer. "Airway Hydration in Sjögren’s Pulmonary Disease." Chest 160, no. 3 (2021): e322. http://dx.doi.org/10.1016/j.chest.2021.04.031.

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Berardicurti, Onorina, Piero Ruscitti, Paola Cipriani, et al. "Cardiovascular Disease in Primary Sjögren’s Syndrome." Reviews on Recent Clinical Trials 13, no. 3 (2018): 164–69. http://dx.doi.org/10.2174/1574887113666180315130336.

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Beider, Sonja, Nadine Zehrfeld, Franziska Maria Tapken, et al. "Premature Ischemic Stroke in Sjögren’s Disease." Journal of Stroke 27, no. 2 (2025): 257–60. https://doi.org/10.5853/jos.2024.03797.

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Başaran, Pınar Özge, and Dilek Eker Büyükşireci. "Evaluating sarcopenia prevalence and relationship with disease activity of primary Sjögren syndrome in females." Universa Medicina 43, no. 3 (2024): 340–48. https://doi.org/10.18051/univmed.2024.v43.340-348.

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BackgroundPrimary Sjögren’s syndrome (pSS) leads to impaired muscle function and mass as well as pain and fatigue. Sarcopenia is the pathological reduction of skeletal muscle mass and strength. We aimed to investigate the prevalence of sarcopenia and determine its relationship with disease activity levels in females with primary Sjögren syndrome. MethodsThis cross-sectional study was performed on 62 female patients diagnosed with pSS and 62 female age matched healthy controls. Disease activity was evaluated with the EULAR Sjögren’s syndrome patient reported index (ESSPRI) and EULAR Sjögren’s s

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Nave, Catarina Bento da, Paula Pereira, and Maria Leonor Silva. "The Effect of Polyunsaturated Fatty Acid (PUFA) Supplementation on Clinical Manifestations and Inflammatory Parameters in Individuals with Sjögren’s Syndrome: A Literature Review of Randomized Controlled Clinical Trials." Nutrients 16, no. 21 (2024): 3786. http://dx.doi.org/10.3390/nu16213786.

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Background. Sjögren’s syndrome is a chronic autoimmune disease that causes dry mouth and eyes and can lead to non-Hodgkin’s lymphoma in 5–10% of cases after 10 years. Clinical trials have shown that the oral administration of polyunsaturated fatty acids (PUFAs) seems to have a beneficial effect on Sjögren’s syndrome. Aim. This literature review provides an overview of the effects of PUFA supplementation on clinical manifestations and inflammatory parameters in Sjögren’s syndrome. Methodology. We conducted a literature review using the PubMed, Biomed Central, and Cochrane Library electronic dat

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Zhou, Yanjun, Nanqu Huang, Guangyu Cao, and Yong Luo. "Type I renal tubular acidosis caused by Sjögren’s syndrome with hypokalemia as the first symptom: a case report." Journal of International Medical Research 48, no. 2 (2019): 030006051988076. http://dx.doi.org/10.1177/0300060519880765.

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Sjögren’s syndrome is a chronic inflammatory autoimmune disease characterized by exocrine gland involvement and marked lymphocytic infiltration. Numerous reports of patients with Sjögren’s syndrome have described kidney damage, mainly involving distal tubule dysfunction, severe renal calcification, kidney stones, and rickets. We herein describe a patient with primary Sjögren’s syndrome who developed type I renal tubular acidosis with hypokalemia as the first symptom. This case highlights the possibility that an underlying autoimmune disorder should be considered in a patient presenting with di

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Maurya, Rajendra P., Vibha Singh, Ashish Gupta, et al. "Dry eye disease associated with Primary Sjogren syndrome: An update." Indian Journal of Clinical and Experimental Ophthalmology 7, no. 2 (2021): 259–69. http://dx.doi.org/10.18231/j.ijceo.2021.055.

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Primary Sjögren’s syndrome (pSS) is a chronic, multisystem autoimmune disorder, characterized by mononuclear infiltration of exocrine glands and other organs, resulting in dry eye, dry mouth and extra-glandular systemic findings. Primary Sjögren syndrome is of particular interest to ophthalmologists as it constitutes an important differential diagnosis in conditions with dry eye disease. The ocular tests are of great importance for diagnosis and monitoring of primary sjogren’s syndrome. Also a better understanding of immunological mechanisms and molecular pathways have resulted in discovery of

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Susic, Gordana, Roksanda Stojanovic, Vera Milic, Ivan Boricic, Bojan Mandic, and Svetislav Milenkovic. "Juvenile Sjögren’s syndrome: Case report." Srpski arhiv za celokupno lekarstvo 141, no. 3-4 (2013): 228–31. http://dx.doi.org/10.2298/sarh1304228s.

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Introduction. Sj?gren?s syndrome (SS) is an autoimmune disease of unknown etiology, clinically manifested by dry eyes (xerophthalmia) and dry mouth (xerostomia). In childhood SS is a rare disease, clinically atypically or asymptomatic and is often unrecognized. We report a girl with asymptomatic, juvenile form of primary Sj?gren?s syndrome (JSS). Case Outline. A 13?year?old girl was initially observed for several months due to elevated sedimentation rate (ESR 75?90 mm/h) without signs of inflammation or other symptoms and disease signs. Subjective symptoms of dryness of the eyes and mouth were

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Lai, Zhennan, Hongen Yin, Javier Cabrera-Pérez, et al. "Aquaporin gene therapy corrects Sjögren’s syndrome phenotype in mice." Proceedings of the National Academy of Sciences 113, no. 20 (2016): 5694–99. http://dx.doi.org/10.1073/pnas.1601992113.

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Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease that is estimated to affect 35 million people worldwide. Currently, no effective treatments exist for Sjögren’s syndrome, and there is a limited understanding of the physiological mechanisms associated with xerostomia and hyposalivation. The present work revealed that aquaporin 5 expression, a water channel critical for salivary gland fluid secretion, is regulated by bone morphogenetic protein 6. Increased expression of this cytokine is strongly associated with the most common symptom of primary Sjögren’s syndrome, the loss of sa

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Daikhes, N. A., N. M. Kotel’nikova, O. V. Karneeva, T. I. Garashchenko, and A. V. Gertsen. "Comprehensive treatment of chronic pathology of larynx in Sjögren’s disease." Russian Otorhinolaryngology 22, no. 5 (2023): 28–38. http://dx.doi.org/10.18692/1810-4800-2023-5-28-38.

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Issues of voice quality and health, as the main means of communication, are becoming increasingly relevant. One of the causes of dysphonia is Sjögren’s disease. Progressive dryness of the mucous membrane of the upper respiratory tract, autoimmune disorders lead to the development of chronic pathology of the vocal apparatus. Treatment methods traditionally used for chronic pathology of the larynx do not achieve high and lasting improvement in voice quality in patients with Sjögren’s disease. The purpose of this study was to evaluate the effectiveness of the developed method of complex treatment

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Sequí-Sabater, Jose Miguel, and Lorenzo Beretta. "Defining the Role of Monocytes in Sjögren’s Syndrome." International Journal of Molecular Sciences 23, no. 21 (2022): 12765. http://dx.doi.org/10.3390/ijms232112765.

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Sjögren’s syndrome is one of the most prevalent autoimmune diseases after rheumatoid arthritis, with a preference for middle age, and is characterised by exocrine glandular involvement leading to xerostomia and xerophthalmia. It can have systemic implications with vascular, neurological, renal, and pulmonary involvement, and in some cases, it may evolve to non-Hodgkin’s lymphoma. For a long time, B- and T-lymphocytes have been the focus of research and have been considered key players in Sjögren’s syndrome pathogenesis and evolution. With the development of new technologies, including omics, m

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Zehrfeld, Nadine, Malin Abelmann, Sabrina Benz, et al. "Primary Sjögren’s syndrome independently promotes premature subclinical atherosclerosis." RMD Open 10, no. 2 (2024): e003559. http://dx.doi.org/10.1136/rmdopen-2023-003559.

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ObjectivesCardiovascular comorbidities are common in patients with autoimmune diseases. This study investigates the extent of subclinical atherosclerosis in patients with primary Sjögren’s syndrome (pSS). Correlations with clinical factors such as organ involvement (OI) or disease activity were analysed and oxLDL antibodies (oxLDL ab) were measured as potential biomarkers of vascular damage.MethodsPatients with pSS were consecutively included from the rheumatology outpatient clinic. Age- and sex-matched controls were recruited (2:1 ratio). Data collection was performed by a standardised questi

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Thorlacius, G. E., A. Björk, and M. Wahren-Herlenius. "POS0820 SEX-EQTL ANALYSIS REVEALS A SIGNIFICANT SEX-BIAS IN THE EFFECTS OF SJÖGREN’S SYNDROME ASSOCIATED ALLELES ON GENE TRANSCRIPTION." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 705.3–705. http://dx.doi.org/10.1136/annrheumdis-2023-eular.6230.

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BackgroundPrimary Sjögren’s syndrome is a systemic autoimmune disease that affects exocrine glands, particularly the salivary- and lacrimal glands, leading to the hallmark symptoms of mucosal dryness. Patients commonly also experience fatigue, joint and muscle pain. Sjögren’s syndrome predominantly affects women, with a female-to-male ratio of 14:1. Genetic risk factors associated with Sjögren’s syndrome have been identified, however, the mechanisms behind the profound sex-bias remain incompletely understood.ObjectivesThe aim of this study was to analyze whether the sex of a carrier of genetic

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Mieliauskaitė, Diana, Vilius Kontenis, and Almantas Šiaurys. "Lessons from Animal Models in Sjögren’s Syndrome." International Journal of Molecular Sciences 24, no. 16 (2023): 12995. http://dx.doi.org/10.3390/ijms241612995.

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Primary Sjögren’s syndrome (pSS) is a connective tissue disease characterized by a wide spectrum of clinical features, extending from a benign glandular disease to an aggressive systemic disorder and/or lymphoma. The pathogenesis of Sjögren’s syndrome (SS) is not completely understood, but it is assumed that pathogenesis of SS is multifactorial. The studies based on the animal models of SS provided significant insight in SS disease pathogenesis and management. The aim of this review is to summarize current studies on animal models with primary SS-like symptoms and discuss the impact of these s

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Bouillot, C., K. M. Hammitt, A. Hjertviksten Lindland, M. Oosterbaan, M. Pincemin, and L. Stone. "AB1732-PARE “FLARE, DID YOU SAY FLARE?” FLARES IN SJÖGREN’S DISEASE: THE PATIENT PERSPECTIVE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 2103.1–2103. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2668.

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Background“Flare” is a word often used by Sjögren’s patients and medical professionals, without any official definition or consensus on what it means. In addition, the heterogeneous nature of Sjögren’s symptoms means that the definition of a “flare” will vary greatly from patient to patient. As part of the European Necessity project,www.necessity-h2020.eu,7 Sjögren’s patients from the Patient Advisory Group (PAG) addressed this issue and hereby present our definition of a Sjögren’s flare from the patient perspective.ObjectivesTo provide a common definition of a flare in Sjögren’s despite the h

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Bodakçi, Erdal. "Clinical Characteristics of Distinct Subgroups of Patients with Primary Sjögren’s Syndrome Classified by Serological Profiles: A Comparison Study." Journal of Personalized Medicine 14, no. 9 (2024): 967. http://dx.doi.org/10.3390/jpm14090967.

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Sjögren’s syndrome (SS) is an autoimmune disease characterized by heterogeneous clinical presentation and the presence of various autoantibodies. This study aimed to determine the differences in clinical findings according to antibody positivity in patients with primary Sjögren syndrome (pSS) in the Turkish population. A retrospective study was conducted and 402 patients (378 women and 24 men) with pSS were analyzed. The patients were categorized into three subgroups based on serological tests. These were (1) quadruple seropositivity (positive for anti-Sjögren’s syndrome-related antigen A anti

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Rios-Fernández, Raquel, José-Luis Callejas-Rubio, Mercedes Caba-Molina, Rosa Ríos-Peregrina, and Norberto Ortego-Centeno. "Mesenteric Inflammatory Venoocclusive Disease in a Patient with Sjögren’s Syndrome." Case Reports in Medicine 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/423420.

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Mesenteric inflammatory venoocclusive disease is an uncommon cause of intestinal ischemia. Certain diseases, such as hypercoagulation disorders, autoimmune diseases, or drugs have been associated with the pathogenesis of mesenteric inflammatory venoocclusive disease. Here, we report a patient with Sjögren’s syndrome who underwent surgery for suspected acute appendicitis with a subsequent pathological diagnosis of mesenteric inflammatory venoocclusive disease.

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Chebli, Selima, Yosra Zgueb, Uta Ouali, Sana Taleb, and Fethi Nacef. "Bipolar Disorder as Comorbidity with Sjögren’s Syndrome: What Can We Do?" Case Reports in Psychiatry 2020 (September 11, 2020): 1–3. http://dx.doi.org/10.1155/2020/8899615.

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Neuropsychiatric manifestations in Sjögren’s syndrome are common and can occur not only during its course, but also at the onset of the disease. Depression and anxiety were the most frequently described symptoms. However, the association with bipolar disorder seems to be rare and not well documented. This case report presents a patient with bipolar disorder as comorbidity with Sjögren’s syndrome, suggesting that bipolar disorder could be associated with this autoimmune disease, which could lead to delaying diagnosis and treatment. A better analysis of the clinical background should be done by

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Jawaid, Mehrin, Yael Ross, and Mohammad Kamran. "PL-7 Antisynthetase Syndrome in Association with Sjögren’s, Systemic Lupus Erythematosus, and Rheumatoid Arthritis." Case Reports in Rheumatology 2020 (February 14, 2020): 1–4. http://dx.doi.org/10.1155/2020/4736476.

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We present a rare case of PL-7 antisynthetase syndrome (ASS) in association with Sjögren’s, systemic lupus erythematosus (SLE), and seropositive rheumatoid arthritis (RA). Initially, the patient was diagnosed with Sjögren’s followed by Sjögren’s/SLE overlap and then Sjögren’s/SLE/RA overlap. She was eventually diagnosed with Sjögren’s/SLE/RA overlap with PL-7 ASS with interstitial lung disease (ILD). ILD was discovered after complaints of pleuritic chest pain with subsequent workup with coronary computed tomography (CT) revealing pulmonary fibrosis. This case demonstrates the ambiguity with wh

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