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1

Yin, Guoling, Xiaoping Li, and Xiaofei Chang. "Paclitaxel liposomes exert radio-sensitization effect on breast cancer cell line SK-BR-3 by regulating expressions of apoptotic proteins." Tropical Journal of Pharmaceutical Research 19, no. 5 (2020): 1009–13. http://dx.doi.org/10.4314/tjpr.v19i5.15.

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Purpose: To study the radio-sanitization effect of paclitaxel liposomes on breast cancer cells, SK-BR-3.Methods: Breast cancer cell line SK-BR-3 was cultured and made into a cell suspension. Four groups of cells were used: control and radiotherapy groups, paclitaxel group, and paclitaxel liposome + radiotherapy group (combination group). The growth inhibitory effects of the different treatments on SKBR-3 cells were determined with CCK-8 method. Apoptosis in each group was evaluated with flow cytometry, while Western blotting was employed to assay Bcl-2, Caspase-3 and Bax protein levels.Results
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2

Özben, RŞ, and D. Cansaran-Duman. "The expression profiles of apoptosis-related genes induced usnic acid in SK-BR-3 breast cancer cell." Human & Experimental Toxicology 39, no. 11 (2020): 1497–506. http://dx.doi.org/10.1177/0960327120930257.

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This study aims to determine whether usnic acid (UA) could induce the expression of apoptosis-related genes in apoptosis pathway. The current study has enabled us to better understand the target of UA in the treatment of breast cancer. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Based on the previous study and the results of this study, UA had the most antiproliferative effect on SK-BR-3 breast cancer cell line. We examined differential expression of 88 apoptosis-related genes by quantitative real-time polymerase chain reaction using the
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3

Lai, Hung-Wen, Su-Yu Chien, Shou-Jen Kuo, et al. "The Potential Utility of Curcumin in the Treatment of HER-2-Overexpressed Breast Cancer: AnIn VitroandIn VivoComparison Study with Herceptin." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/486568.

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HER-2 is an important oncoprotein overexpressed in about 15–25% of breast cancers. We hypothesized that the ability of curcumin to downregulate HER-2 oncoprotein and inhibit the signal transduction pathway of PI3K/Akt, MAPK, and NF-κB activation may be important in the treatment of HER-2-overexpressed breast cancer. To examine the effect of curcumin on breast cancer cells, MCF-7, MDA-MB-231, MCF-10A, BT-474, and SK-BR-3-hr (a herceptin resistant strain from SK-BR-3) cells were used forin vitroanalysis. Thein vivoeffect of curcumin on HER-2-overexpressed breast cancer was investigated with the
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4

Xiao, Yan, Xiugong Gao, Samantha Maragh, William G. Telford, and Alessandro Tona. "Cell Lines as Candidate Reference Materials for Quality Control of ERBB2 Amplification and Expression Assays in Breast Cancer." Clinical Chemistry 55, no. 7 (2009): 1307–15. http://dx.doi.org/10.1373/clinchem.2008.120576.

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Abstract Background: Human epidermal growth factor receptor 2 (HER2) is an important biomarker whose status plays a pivotal role in therapeutic decision-making for breast cancer patients and in determining their clinical outcomes. Ensuring the accuracy and reproducibility of HER2 assays by immunohistochemistry (IHC) and by fluorescence in situ hybridization (FISH) requires a reliable standard for monitoring assay sensitivity and specificity, and for assessing methodologic variation. A prior NIST workshop addressed this need by reaching a consensus to create cell lines as reference materials fo
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5

Thakur, Archana, Zaid Al-Kadhimi, Cassara Pray, et al. "Transfer of Cellular and Humoral Anti-Tumor Immunity with Immune T Cells After Stem Cell Transplant (SCT) for Metastatic Breast Cancer Following “Vaccination” with Anti-CD3 x Anti-Her2/Neu Bispecific Antibody (Her2Bi) Armed Activated T Cells." Blood 118, no. 21 (2011): 1914. http://dx.doi.org/10.1182/blood.v118.21.1914.1914.

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Abstract Abstract 1914 Novel therapeutic approaches are needed for women with metastatic breast cancer (BrCa). In our phase I clinical trial, infusions of anti-CD3 activated T cells (ATC) armed with anti-CD3 x anti-Her2/neu bispecific antibody (Her2Bi) induced specific cytotoxicity (SC) directed at SK-BR-3 breast cancer cells by fresh peripheral blood lymphocytes (PBL) and induced elevated serum levels of Th1 cytokines. In this study, we took advantage of armed ATC induced anti-tumor immune responses by infusing “immune” T cells collected by leukopheresis. We expanded “immune T cells” with ant
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Do, Ha Thi Thu, та Jungsook Cho. "Involvement of the ERK/HIF-1α/EMT Pathway in XCL1-Induced Migration of MDA-MB-231 and SK-BR-3 Breast Cancer Cells". International Journal of Molecular Sciences 22, № 1 (2020): 89. http://dx.doi.org/10.3390/ijms22010089.

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Chemokine–receptor interactions play multiple roles in cancer progression. It was reported that the overexpression of X-C motif chemokine receptor 1 (XCR1), a specific receptor for chemokine X-C motif chemokine ligand 1 (XCL1), stimulates the migration of MDA-MB-231 triple-negative breast cancer cells. However, the exact mechanisms of this process remain to be elucidated. Our study found that XCL1 treatment markedly enhanced MDA-MB-231 cell migration. Additionally, XCL1 treatment enhanced epithelial–mesenchymal transition (EMT) of MDA-MB-231 cells via E-cadherin downregulation and upregulation
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7

Kumar, Naresh, Pankaj Attri, Eun Ha Choi, and Han Sup Uhm. "Influence of water vapour with non-thermal plasma jet on the apoptosis of SK-BR-3 breast cancer cells." RSC Advances 5, no. 19 (2015): 14670–77. http://dx.doi.org/10.1039/c4ra15879b.

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8

Afrakhteh, Moslem, Alireza Kheirollah, Aminollah Pourshohod, Mohammad Ali Ghaffari, Mostafa Jamalan, and Majid Zeinali. "Cytotoxicity of Sodium Arsenite-loaded Anti-HER2 Immunoliposomes Against HER2-expressing Human Breast Cancer Cell Lines." Letters in Drug Design & Discovery 16, no. 5 (2019): 556–62. http://dx.doi.org/10.2174/1570180815666180803120409.

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Background: Chemotherapy is a routine approach in treatment of patients with cancer, while side effects of chemotherapeutic drugs are inevitable. To minimize side effects, specific targeting of neoplastic cells is a promising strategy in cancer therapy. Sodium arsenite is a metalloid toxin with anti-neoplastic properties, but low selectivity and carcinogenic activity have limited its clinical usage. Methods: Targeting of HER2-overexpressing (SK-BR-3) and HER2-low expressing (MCF-7) cancerous breast cell lines by two different liposomal forms of sodium arsenite (bare liposome and trastuzumab-co
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9

Hossain, Md Imran, Ajit G. Thomas, Fakhri Mahdi та ін. "An efficient synthetic route to l-γ-methyleneglutamine and its amide derivatives, and their selective anticancer activity". RSC Advances 11, № 13 (2021): 7115–28. http://dx.doi.org/10.1039/d0ra08249j.

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l-γ-Methyleneglutamic acid amides selectively inhibit the growth of MCF-7 (ER<sup>+</sup>/PR<sup>+</sup>/HER2<sup>−</sup>), SK-BR-3 (ER<sup>−</sup>/PR<sup>−</sup>/HER2<sup>+</sup>), and triple negative MDA-MB-231 cancer cell lines.
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10

Hester, Anna, Barbara Salzmann, Martina Rahmeh, et al. "EP3 receptor antagonist L798,106 reduces proliferation and migration of SK-BR-3 breast cancer cells." OncoTargets and Therapy Volume 12 (July 2019): 6053–68. http://dx.doi.org/10.2147/ott.s204919.

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11

INNAJAK, SUKANDA, WILAWAN MAHABUSRAKUM, and RAMIDA WATANAPOKASIN. "Goniothalamin induces apoptosis associated with autophagy activation through MAPK signaling in SK-BR-3 cells." Oncology Reports 35, no. 5 (2016): 2851–58. http://dx.doi.org/10.3892/or.2016.4655.

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12

Zeng, Guofang, Shaoxi Cai, Yuan Liu, and Guang-Jer Wu. "METCAM/MUC18 augments migration, invasion, and tumorigenicity of human breast cancer SK-BR-3 cells." Gene 492, no. 1 (2012): 229–38. http://dx.doi.org/10.1016/j.gene.2011.10.024.

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13

Sehdev, Vikas, James C. K. Lai, and Alok Bhushan. "Biochanin A Modulates Cell Viability, Invasion, and Growth Promoting Signaling Pathways in HER-2-Positive Breast Cancer Cells." Journal of Oncology 2009 (2009): 1–10. http://dx.doi.org/10.1155/2009/121458.

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Overexpression of HER-2 receptor is associated with poor prognosis and aggressive forms of breast cancer. Scientific literature indicates a preventive role of isoflavones in cancer. Since activation of HER-2 receptor initiates growth-promoting events in cancer cells, we studied the effect of biochanin A (an isoflavone) on associated signaling events like receptor activation, downstream signaling, and invasive pathways. HER-2-positive SK-BR-3 breast cancer cells, MCF-10A normal breast epithelial cells, and NIH-3T3 normal fibroblast cells were treated with biochanin A (2–100 μM) for 72 hours. Su
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14

Guryev, Evgenii L., Natalia O. Volodina, Natalia Y. Shilyagina, et al. "Radioactive (90Y) upconversion nanoparticles conjugated with recombinant targeted toxin for synergistic nanotheranostics of cancer." Proceedings of the National Academy of Sciences 115, no. 39 (2018): 9690–95. http://dx.doi.org/10.1073/pnas.1809258115.

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We report combined therapy using upconversion nanoparticles (UCNP) coupled to two therapeutic agents: beta-emitting radionuclide yttrium-90 (90Y) fractionally substituting yttrium in UCNP, and a fragment of the exotoxin A derived fromPseudomonas aeruginosagenetically fused with a targeting designed ankyrin repeat protein (DARPin) specific to HER2 receptors. The resultant hybrid complex UCNP-R-T was tested using human breast adenocarcinoma cells SK-BR-3 overexpressing HER2 receptors and immunodeficient mice, bearing HER2-positive xenograft tumors. The photophysical properties of UCNPs enabled b
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15

Ling, Binbing, Bosong Gao, and Jian Yang. "Evaluating the Effects of Tetrachloro-1,4-benzoquinone, an Active Metabolite of Pentachlorophenol, on the Growth of Human Breast Cancer Cells." Journal of Toxicology 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/8253726.

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Tetrachloro-1,4-benzoquinone (TCBQ), an active metabolite of pentachlorophenol (PCP), is genotoxic and potentially carcinogenic. As an electrophilic and oxidative molecule, TCBQ can conjugate with deoxyguanosine in DNA molecules and/or impose oxidative stress in cells. In the current study, we investigated the effects of TCBQ on intracellular ROS production, apoptosis, and cytotoxicity against three different subtypes of human breast cancer cells. Luminal A subtype MCF7 (ER+, PR+, HER2−) cells maintained the highest intracellular ROS level and were subjected to TCBQ-induced ROS reduction, apop
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16

Poturnayová, Alexandra, Ľudmila Dzubinová, Monika Buríková, Jozef Bízik, and Tibor Hianik. "Detection of Breast Cancer Cells Using Acoustics Aptasensor Specific to HER2 Receptors." Biosensors 9, no. 2 (2019): 72. http://dx.doi.org/10.3390/bios9020072.

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Detection of the breast cancer cells is important for early diagnosis of the cancer. We applied thickness shear mode acoustics method (TSM) for detection of SK-BR-3 breast cancer cells using DNA aptamers specific to HER2 positive membrane receptors. The biotinylated aptamers were immobilized at the neutravidin layer chemisorbed at gold surface of TSM transducer. Addition of the cells resulted in decrease of resonant frequency, fs, and in increase of motional resistance, Rm. Using gold nanoparticles (AuNPs), modified by aptamers it was possible improving the limit of detection (LOD) that reache
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17

Damiani, Isabella, Silvia Castiglioni, Alicja Sochaj-Gregorczyk, et al. "Purification and In Vitro Evaluation of an Anti-HER2 Affibody-Monomethyl Auristatin E Conjugate in HER2-Positive Cancer Cells." Biology 10, no. 8 (2021): 758. http://dx.doi.org/10.3390/biology10080758.

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A promising approach for the development of high-affinity tumor targeting ADCs is the use of engineered protein drugs, such as affibody molecules, which represent a valuable alternative to monoclonal antibodies (mAbs) in cancer-targeted therapy. We developed a method for a more efficient purification of the ZHER2:2891DCS affibody conjugated with the cytotoxic antimitotic agent auristatin E (MMAE), and its efficacy was tested in vitro on cell viability, proliferation, migration, and apoptosis. The effects of ZHER2:2891DCS-MMAE were compared with the clinically approved monoclonal antibody trast
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18

Sanaei, Masumeh, and Fraidoon Kavoosi. "Effect of Trichostatin A on Histone Deacetylases 1, 2 and 3, p21Cip1/Waf1/Sdi1, p27Kip1, and p57Kip2 Gene Expression in Breast Cancer SK-BR-3 Cell Line." Asian Pacific Journal of Cancer Biology 5, no. 2 (2020): 57–62. http://dx.doi.org/10.31557/apjcb.2020.5.2.57-62.

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Objective: DNA methylation, the covalent addition of a methyl group to cytosine, and histone modification play an important role in the establishment and maintenance of the program of gene expression. The balance of histone acetylation is determined by the activities of two groups of enzymes including histone acetyltransferases (HATs) and histone deacetylases (HDACs). Histone deacetylation is generally associated with silencing gene expression resulting in several solid tumors. HDAC inhibitors (HDACIs) are the new class of potential anticancer compounds for the treatment of the solid and hemat
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19

De Corte, V., C. De Potter, D. Vandenberghe, et al. "A 50 kDa protein present in conditioned medium of COLO-16 cells stimulates cell spreading and motility, and activates tyrosine phosphorylation of Neu/HER-2, in human SK-BR-3 mammary cancer cells." Journal of Cell Science 107, no. 3 (1994): 405–16. http://dx.doi.org/10.1242/jcs.107.3.405.

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A factor present in conditioned medium of COLO-16 human cancer cells causes fast spreading, fast plasma membrane ruffling, cell shape change, net translocation, stimulation of chemotaxis and growth arrest in human SK-BR-3 mammary cancer cells. Based on the spreading effect, the factor was purified to homogeneity and migrated as a 50 kDa protein in SDS-polyacrylamide gel electrophoresis. Addition of the purified 50 kDa factor to the target cells in culture results in tyrosine phosphorylation of the p185erbB2 receptor concomitant with a fast redistribution and clustering of the receptor. The 50
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20

Zhu, Kun, Kang Li, Haonan Wang, Li Kang, Chengxue Dang, and Yong Zhang. "Discovery of Glabridin as Potent Inhibitor of Epidermal Growth Factor Receptor in SK-BR-3 Cell." Pharmacology 104, no. 3-4 (2019): 113–25. http://dx.doi.org/10.1159/000496798.

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The breast cancer is the leading cause of death in women. Therefore, objective of the present study was to examine the antibreast cancer effect of glabridin (GBN) and to evaluate its mechanism of action. In this study, we have demonstrated that GBN causes reduction of cellular viability of human breast cancer SK-BR-3 in MTT assay. Results from Hoechst 33342 and propidium iodide staining assay suggested that GBN causes significant enhancement in the apoptosis. At the molecular level, in western blot analysis, GBN causes significant increase in c-PARP and c-caspases 3, 8, and 9 concentrations in
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21

Vaidyanath, Arun, Toshihiro Hashizume, Tadahiro Nagaoka, et al. "Enhanced internalization of ErbB2 in SK-BR-3 cells with multivalent forms of an artificial ligand." Journal of Cellular and Molecular Medicine 15, no. 11 (2011): 2525–38. http://dx.doi.org/10.1111/j.1582-4934.2011.01277.x.

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22

Shahinfar, Parvaneh, Nasrin Motamed, Elnaz Birjandian, and Omid Shabanpour. "Silibinin: An Inhibitor of Mir-181a Gene Expression in Sk-Br-3 Breast Cancer Cell Line." Indian Journal of Pharmaceutical Education and Research 51, no. 4 (2017): 597–602. http://dx.doi.org/10.5530/ijper.51.4.89.

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23

Weißenborn, Christine, Tanja Ignatov, Angela Poehlmann, et al. "GPER functions as a tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells." Journal of Cancer Research and Clinical Oncology 140, no. 4 (2014): 663–71. http://dx.doi.org/10.1007/s00432-014-1598-2.

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24

Jamshidifar, Elham, Faten Eshrati Yeganeh, Mona Shayan, et al. "Super Magnetic Niosomal Nanocarrier as a New Approach for Treatment of Breast Cancer: A Case Study on SK-BR-3 and MDA-MB-231 Cell Lines." International Journal of Molecular Sciences 22, no. 15 (2021): 7948. http://dx.doi.org/10.3390/ijms22157948.

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In the present study, a magnetic niosomal nanocarrier for co-delivery of curcumin and letrozole into breast cancer cells has been designed. The magnetic NiCoFe2O4 core was coated by a thin layer of silica, followed by a niosomal structure, allowing us to load letrozole and curcumin into the silica layer and niosomal layer, respectively, and investigate their synergic effects on breast cancer cells. Furthermore, the nanocarriers demonstrated a pH-dependent release due to the niosomal structure at their outer layer, which is a promising behavior for cancer treatment. Additionally, cellular assay
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Koleva, Vanya, Asya Dragoeva, Marian Draganov, et al. "Inhibition of growth and induction of apoptosis in human lung cancer cells by Br-oxph." Genetika 46, no. 1 (2014): 1–10. http://dx.doi.org/10.2298/gensr1401001k.

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The study was aimed at evaluating apoptotic potential of Br-oxph (4-bromoN,N-diethyl-5,5-dimethyl-2,5-dihydro-1,2-oxaphosphol-2-amine 2-oxide) in vitro. The dose response effect of Br-oxph (dose range 1-3 mg/ml, for 48 h) on SK-MES-1 cells viability was determined by means of WST-1 cell proliferation assay. The half maximal inhibitory concentration (??50) value was determined - 1.8 mg/ml. The ability of the compound tested to induce apoptosis was tested by ELISA to detect cellular DNA fragmentation. We provided a quantitative assessment of the apoptotic potential of Br-oxph in human lung carci
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26

Pothinuch, Pitchaya, and Sasitorn Tongchitpakdee. "Phenolic Analysis for Classification of Mulberry (Morus spp.) Leaves according to Cultivar and Leaf Age." Journal of Food Quality 2019 (October 20, 2019): 1–11. http://dx.doi.org/10.1155/2019/2807690.

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Phenolic compounds in mulberry leaves harvested from three cultivars (Buriram 60, BR 60; Sakonnakhon, SK; and Khunphai, KH) at different leaf ages (tips, young, and old leaves) were identified and quantified using HPLC-DAD and HPLC-ESI/MS. A total of 13 phenolic compounds, which were mainly as caffeoylquinic acids and flavonol glycosides, were detectable. Predominant phenolic compounds were 5-O-caffeoylquinic acid (3.5–13.1 mg/g dry weight), 4-O-caffeoylquinic acid (1.3–2.4 mg/g dry weight), and quercetin-3-O-rutinoside (1.0–4.4 mg/g dry weight). Qualitative and quantitative differences in phe
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Filippi, Alexandru, Tiphanie Picot, Carmen Mariana Aanei, et al. "Epigallocatechin-3-O-gallate alleviates the malignant phenotype in A-431 epidermoid and SK-BR-3 breast cancer cell lines." International Journal of Food Sciences and Nutrition 69, no. 5 (2017): 584–97. http://dx.doi.org/10.1080/09637486.2017.1401980.

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28

Sebastian, Joseph A., Michael J. Moore, Elizabeth S. L. Berndl, and Michael C. Kolios. "An image-based flow cytometric approach to the assessment of the nucleus-to-cytoplasm ratio." PLOS ONE 16, no. 6 (2021): e0253439. http://dx.doi.org/10.1371/journal.pone.0253439.

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The nucleus-to-cytoplasm ratio (N:C) can be used as one metric in histology for grading certain types of tumor malignancy. Current N:C assessment techniques are time-consuming and low throughput. Thus, in high-throughput clinical contexts, there is a need for a technique that can assess cell malignancy rapidly. In this study, we assess the N:C ratio of four different malignant cell lines (OCI-AML-5—blood cancer, CAKI-2—kidney cancer, HT-29—colon cancer, SK-BR-3—breast cancer) and a non-malignant cell line (MCF-10A –breast epithelium) using an imaging flow cytometer (IFC). Cells were stained wi
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Candrasari, Dewi Puspita, Subur Priyono Sasmito Budhi, and Hari Hartadi. "PERLAKUAN KALSIUM HIDROKSIDA DAN UREA UNTUK MENINGKATKAN KUALITAS BAGAS TEBU." Buletin Peternakan 35, no. 3 (2012): 165. http://dx.doi.org/10.21059/buletinpeternak.v35i3.1089.

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&lt;p&gt;Penelitian bertujuan untuk konservasi hasil sisa tanaman pertanian berupa bagas tebu, meningkatkan kecernaan dan meningkatkan nilai N bagas tebu sehingga dapat digunakan sebagai pakan. Level Ca(OH)2 (b/b) yang digunakan&lt;br /&gt;sebesar 0, 3, dan 6%. Level urea yang digunakan adalah 0, 3, dan 6%. Masing–masing perlakuan diulang sebanyak 3 kali. Penelitian menggunakan rancangan acak lengkap pola faktorial 3 x 3. Setelah diberi perlakuan, bagas tebu&lt;br /&gt;ditempatkan pada kantong plastik polyethylene dan disimpan selama 21 hari. Data yang diperoleh dianalisis variansi dan apabila
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Huang, Chang-Yu, and Guang-Jer Wu. "METCAM/MUC18 promoted tumorigenesis of human breast cancer SK-BR-3 cells in a dosage-specific manner." Taiwanese Journal of Obstetrics and Gynecology 55, no. 2 (2016): 202–12. http://dx.doi.org/10.1016/j.tjog.2016.02.010.

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Brockhoff, G., B. Heckel, E. Schmidt-Bruecken, et al. "Differential impact of Cetuximab, Pertuzumab and Trastuzumab on BT474 and SK-BR-3 breast cancer cell proliferation." Cell Proliferation 40, no. 4 (2007): 488–507. http://dx.doi.org/10.1111/j.1365-2184.2007.00449.x.

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Wang, Bing, Ming-zhi Zhao, Nai-peng Cui, et al. "Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells." FEBS Open Bio 5, no. 1 (2015): 147–54. http://dx.doi.org/10.1016/j.fob.2015.02.003.

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Moradipoodeh, Bahman, Mostafa Jamalan, Majid Zeinali, Masood Fereidoonnezhad, and Ghorban Mohammadzadeh. "Specific targeting of HER2-positive human breast carcinoma SK-BR-3 cells by amygdaline-ZHER2 affibody conjugate." Molecular Biology Reports 47, no. 9 (2020): 7139–51. http://dx.doi.org/10.1007/s11033-020-05782-z.

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Miranda, Ana Cláudia Camargo, Sofia Nascimento dos Santos, Leonardo Lima Fuscaldi, et al. "Radioimmunotheranostic Pair Based on the Anti-HER2 Monoclonal Antibody: Influence of Chelating Agents and Radionuclides on Biological Properties." Pharmaceutics 13, no. 7 (2021): 971. http://dx.doi.org/10.3390/pharmaceutics13070971.

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The oncogene HER2 is an important molecular target in oncology because it is associated with aggressive disease and the worst prognosis. The development of non-invasive imaging techniques and target therapies using monoclonal antibodies is a rapidly developing field. Thus, this work proposes the study of the radioimmunotheranostic pair, [111In]In-DTPA-trastuzumab and [177Lu]Lu-DOTA-trastuzumab, evaluating the influence of the chelating agents and radionuclides on the biological properties of the radioimmunoconjugates (RICs). The trastuzumab was immunoconjugated with the chelators DTPA and DOTA
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Sholina, N. V., R. A. Akasov, D. A. Khochenkov, A. N. Generalova, V. A. Semchishen та E. V. Khaydukov. "In vitro и in vivo photodynamic therapy of solid tumors with a combination of riboflavin and upconversion nanoparticles". Almanac of Clinical Medicine 47, № 7 (2019): 647–53. http://dx.doi.org/10.18786/2072-0505-2019-47-057.

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Rationale: Riboflavin (vitamin B2) is one of the most promising agents for photodynamic therapy (PDT). However, its use is limited by the excitation in the ultraviolet (UV) and visible spectral ranges and, as a result, by a small penetration into biological tissue not exceeding a few millimeters. This problem could be solved by approaches ensuring excitation of riboflavin molecules within tumor tissues by infrared (IR) light. Upconversion nanoparticles (UCNPs) can be potentially considered as mediators able to effectively convert the exciting radiation of the near IR range, penetrating into bi
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Azevedo-Silva, João, Odília Queirós, Ana Ribeiro, et al. "The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH." Biochemical Journal 467, no. 2 (2015): 247–58. http://dx.doi.org/10.1042/bj20140921.

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Although the anti-cancer properties of 3BP (3-bromopyruvate) have been described previously, its selectivity for cancer cells still needs to be explained [Ko et al. (2001) Cancer Lett. 173, 83–91]. In the present study, we characterized the kinetic parameters of radiolabelled [14C] 3BP uptake in three breast cancer cell lines that display different levels of resistance to 3BP: ZR-75-1 &lt; MCF-7 &lt; SK-BR-3. At pH 6.0, the affinity of cancer cells for 3BP transport correlates with their sensitivity, a pattern that does not occur at pH 7.4. In the three cell lines, the uptake of 3BP is depende
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Wang, Yun, Wai Man Gho, Franky L. Chan, Shiuan Chen, and Lai K. Leung. "The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression." British Journal of Nutrition 99, no. 2 (2008): 303–10. http://dx.doi.org/10.1017/s0007114507811974.

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Biochanin A is an isoflavone isolated from red clover (Trifolium pratense), and is a commercially available nutraceutical for women suffering from postmenopausal symptoms. Isoflavones resemble the structure of oestrogen, and display agonistic and antagonistic interactions with the oestrogen receptor. Overexposure of oestrogen is a major contributing factor in the development of breast cancer, and cytochrome P450 (CYP) 19 enzyme, or aromatase, catalyses the reaction converting androgen to oestrogen. In the present study the effect of biochanin A on the gene regulation and enzyme activity of aro
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Amoozadeh, Sahel, Mohammad Morad Farajollahi, Maryam Hemmati, and Parastoo Tarighi. "Cytotoxic Effect of Post-Purified Herceptin Conjugated Recombinant Diphtheria Toxin on Sk-Br-3 Breast Cancer Cell Line." Multidisciplinary Cancer Investigation 1, Supplementary 1 (2017): 0. http://dx.doi.org/10.21859/mci-supp-30.

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Wang, Ting, Yu Deng, Guanwen Qu, et al. "Cell microarray chip system for accurate, rapid diagnosis and target treatment of breast cancer cells SK-BR-3." Chinese Chemical Letters 30, no. 5 (2019): 1043–50. http://dx.doi.org/10.1016/j.cclet.2019.01.011.

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Lee, Min-Gu, Kyu-Shik Lee, and Kyung-Soo Nam. "Arctigenin-mediated cell death of SK-BR-3 cells is caused by HER2 inhibition and autophagy-linked apoptosis." Pharmacological Reports 73, no. 2 (2021): 629–41. http://dx.doi.org/10.1007/s43440-021-00223-5.

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41

Arrick, B. A., R. L. Grendell, and L. A. Griffin. "Enhanced translational efficiency of a novel transforming growth factor beta 3 mRNA in human breast cancer cells." Molecular and Cellular Biology 14, no. 1 (1994): 619–28. http://dx.doi.org/10.1128/mcb.14.1.619.

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The mRNA for transforming growth factor beta 3 (TGF-beta 3) includes a long (1.1-kb) 5' noncoding region which exerts a potent inhibitory effect on translational efficiency. We now report that many human breast cancer cell lines (T47-D, SK-BR-3, ZR-75-1, and BT-474) express two mRNA species for TGF-beta 3: the 3.5-kb transcript previously described as the only TGF-beta 3 mRNA species in cells and a novel 2.6-kb transcript which lacks approximately 870 nucleotides from the 5' noncoding region. The 5' end of the shorter transcript was sequenced, establishing it to be a 5' truncation of the full-
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42

Arrick, B. A., R. L. Grendell, and L. A. Griffin. "Enhanced translational efficiency of a novel transforming growth factor beta 3 mRNA in human breast cancer cells." Molecular and Cellular Biology 14, no. 1 (1994): 619–28. http://dx.doi.org/10.1128/mcb.14.1.619-628.1994.

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The mRNA for transforming growth factor beta 3 (TGF-beta 3) includes a long (1.1-kb) 5' noncoding region which exerts a potent inhibitory effect on translational efficiency. We now report that many human breast cancer cell lines (T47-D, SK-BR-3, ZR-75-1, and BT-474) express two mRNA species for TGF-beta 3: the 3.5-kb transcript previously described as the only TGF-beta 3 mRNA species in cells and a novel 2.6-kb transcript which lacks approximately 870 nucleotides from the 5' noncoding region. The 5' end of the shorter transcript was sequenced, establishing it to be a 5' truncation of the full-
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43

Moradipoodeh, Bahman, Mostafa Jamalan, Majid Zeinali, Masood Fereidoonnezhad, and Ghorban Mohammadzadeh. "In vitro and in silico anticancer activity of amygdalin on the SK-BR-3 human breast cancer cell line." Molecular Biology Reports 46, no. 6 (2019): 6361–70. http://dx.doi.org/10.1007/s11033-019-05080-3.

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Honjo, Kie, Taiji Hamada, Takuya Yoshimura, et al. "PCP4/PEP19 upregulates aromatase gene expression via CYP19A1 promoter I.1 in human breast cancer SK-BR-3 cells." Oncotarget 9, no. 51 (2018): 29619–33. http://dx.doi.org/10.18632/oncotarget.25651.

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Zabrecky, J. R., T. Lam, S. J. McKenzie, and W. Carney. "The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells, SK-BR-3." Journal of Biological Chemistry 266, no. 3 (1991): 1716–20. http://dx.doi.org/10.1016/s0021-9258(18)52354-1.

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Flicker, Sabine H., Sonja M. Schneider, Martin Offterdinger та ін. "Tyrosine kinase signaling pathways control the expression of retinoic acid receptor-α in SK-BR-3 breast cancer cells". Cancer Letters 115, № 1 (1997): 63–72. http://dx.doi.org/10.1016/s0304-3835(97)04715-0.

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Wu, James T., Ping Zhang, Mark E. Astill, Bradley W. Lyons, and Lily H. Wu. "Identification and characterization of c-erbb-2 proteins in serum, breast tumor tissue, and sk-br-3 cell line." Journal of Clinical Laboratory Analysis 9, no. 3 (1995): 141–50. http://dx.doi.org/10.1002/jcla.1860090302.

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Danafar, Hossein, Ali Sharafi, Sonia Askarlou, and Hamidreza Manjili. "Preparation and Characterization of PEGylated Iron Oxide-Gold Nanoparticles for Delivery of Sulforaphane and Curcumin." Drug Research 67, no. 12 (2017): 698–704. http://dx.doi.org/10.1055/s-0043-115905.

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AbstractNatural products have been used for the treatment of various diseases such as cancer. Curcumin (CUR) and sulforaphane (SF) have anti-cancer effects, but their application is restricted because of their low water solubility and poor oral bioavailability. To improve the bioavailability and solubility of SF and CUR, we performed an advanced delivery of SF and CUR with PEGylated gold coated Fe3O4 magnetic nanoparticles (PEGylated Fe3O4@Au NPs) to endorse SF and CUR maintenance as an effective and promising antitumor drugs. The structure of the synthesized nanocarrieris evaluated by, transm
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Keyvani, Saeideh, Nasrin Karimi, Zahra Orafa, Saeid Bouzari, and Mana Oloomi. "Assessment of Cytokeratin-19 Gene Expression in Peripheral Blood of Breast Cancer Patients and Breast Cancer Cell Lines." Biomarkers in Cancer 8 (January 2016): BIC.S38229. http://dx.doi.org/10.4137/bic.s38229.

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Detection of cytokeratin-19 (CK19) expression as an epithelial-specific marker in circulating tumor cells (CTCs) of breast cancer patients can be important for diagnostic purposes. Comparison of CK19 expression in breast cancer cell lines can indicate that expression of this marker is different in various breast cancer cell lines based on their category. Thirty-five breast cancer patients were evaluated for detection of CK19 mRNA in their peripheral blood using CK19-specific primers and a nested reverse transcriptase polymerase chain reaction (RT-PCR) technique. CK19 expression levels were det
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Chaiyana, Wantida, Jakkapan Sirithunyalug, Suvimol Somwongin, et al. "Enhancement of the Antioxidant, Anti-Tyrosinase, and Anti-Hyaluronidase Activity of Morus alba L. Leaf Extract by Pulsed Electric Field Extraction." Molecules 25, no. 9 (2020): 2212. http://dx.doi.org/10.3390/molecules25092212.

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In this study we aimed to compare the chemical composition and biological activity between Morus alba L. leaf extract obtained with 95% v/v ethanol using a pulsed electric field (PEF) and the conventional maceration method. Extracts of M. alba leaves collected from Chiang Mai (CM), Sakon Nakon (SK), and Buriram (BR), Thailand, were investigated for 1-deoxynojirimycin content by high-performance liquid chromatography and for total phenolic content by the Folin–Ciocalteu method. Antioxidant activity was investigated by 2,2′-diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azinobis-3-ethylbenzothiazoline-6
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