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1
Johnson, Debra Elaine. "Glory B 2 God." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/art_design_theses/28.
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The purpose of this thesis paper is to investigate womanist theology and method, along with restoration practices involving spirituality and healing within the context of the visual arts. The thesis exhibition will attempt to create new visual possibilities that inform womanist theological scholarship in terms of promoting contemporary female religious imagery within a metaphorical language. While womanist theology is steeped in interdisciplinary practices, it has yet to consider seriously the studio arts as a means to explore and develop the womanist language. This study will investigate how essential and natural the visual arts assist our understanding of spirituality, especially through a womanist context.
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Ziegler, Andreas. "Neue Organoborane aus C 2 B 2 -Bausteinen." [S.l. : s.n.], 2001. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB9142812.
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Wiesner, Jürgen. "Parmenides : der Beginn der Aletheia : Untersuchungen zu B 2 - B 3 - B 6 /." Berlin : W. de Gruyter, 1996. http://catalogue.bnf.fr/ark:/12148/cb36186284w.
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Humanos, Profesores del curso Recursos. "Recursos humanos: unidad 2(b), material del alumno 2007-2." Universidad Peruana de Ciencias Aplicadas - UPC, 2007. http://hdl.handle.net/10757/272570.
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Bayer, Michael J. "Neue Carborane aus CB 2 -, CB 3 - und C 2 B 2 -Organoboranen." [S.l. : s.n.], 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB9837041.
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Carrillo, Arregui Jokin. "Síntesis Total de la Anfidinolida B(2)." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/346351.
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En el transcurso de esta tesis se ha trabajado en la síntesis total de la Anfidinolida B2. Ésta es una macrolactona citotóxica aislada de un dinoflagelado marino (Amphidinium sp.) por el grupo de Shimizu y colaboradores en Brewer’s Bay, St. Thomas, Virgin Island. Como los espectros de la Anfidinolida B2 son muy parecidos al de la Anfidinolida B1 (cristalizada y cuya configuración absoluta pudo determinarse por Rayos X y experimentos de degradación), B2 se consideró un epímero en C18 de la B1. Sin embargo, su estructura sigue siendo incierta ya que Carter et al. sintetizaron la estructura propuesta por Shimizu y observaron que los datos espectroscópicos no coincidían con la natural.
La retrosíntesis planteada en nuestro grupo se basa en cuatro desconexiones principales que dan lugar a cuatro fragmentos de complejidad estructural.
El Fragmento I se ha sintetizado a través de una alilación asimétrica de la cetona metílica, transformación apenas usada en síntesis totales. Después de probar varias metodologías optamos por utilizar la alilación asimétrica de Schaus, que nos proporcionó nuestro alcohol alílico en un 95% de rendimiento y una relación enantiomérica de 95:5. De esta manera pudimos optimizar la síntesis de primera generación de este fragmento llevada a cabo por la Dra. Mireia Sidera, obteniendo el alcohol en 3 etapas y un rendimiento total del 32%.
El Fragmento II, se ha conseguido sintetizar a través de un exhaustivo estudio de la apertura del 3,5-dimetiltetrahidrofuran-2-ol donde el 2,2,2-trifluoroetanol es un aditivo clave en la olefinación de Wittig para evitar la posible adición conjugada que da lugar al producto cíclico. La síntesis del fragmento se ha llevado a cabo a través de una dihidroxilación asimétrica de Sharpless, formación de la amida de morfolina y posterior intercambio a cetona vinílica.
La síntesis del Fragmento III ha supuesto un estudio de la reacción de Negishi, donde se ha intentado realizar un coupling Csp3–Csp2, habiendo sido imposible obtener altos rendimientos. No obstante, la unión de un intermedio del Fragmento III con el Fragmento I, también mediante reacción de Negishi, nos ha permitido formar el enlace C13–C14 de la Anfidinolida B2. Una vez realizada esta unión, sí que se ha podido llevar a cabo la unión Csp3–Csp2 para alargar la cadena del Fragmento III y acabar epoxidando mediante una reacción organocatalítica de Jørgensen la posición α,β del aldehído que sirve para la unión con el Fragmento IV.
Los resultados de los experimentos de la reacción de Negishi han servido para extrapolarlos a otros acoplamientos que habían resultado problemáticos con anterioridad en el grupo. Así, se ha realizado la síntesis de la Palmerolida A, macrólido inhibidor del melanoma aislado en 2006 por Baker y colaboradores, aplicando las condiciones optimizadas con anterioridad.
Finalmente, la síntesis del Fragmento IV mediante reacciones triviales nos ha llevado a la unión de éste con el Fragmento Oeste a través de la reacción de Julia-Kocienski. Actualmente nos encontramos estudiando la saponificación y posterior esterificación para la obtención del macrociclo que dará lugar a la Anfidinolida B2.The present Doctoral Thesis describes our efforts towards the Total Synthesis of Amphidinolide B2, a novel macrolide with potent cytotoxicity against lymphoma murine cells and humane carcinoma cells. It is a 26-membered ring macrolactone, with an allylic epoxide, four doble bonds and 9 stereogenic centres. However, the absolute configuration is still unknown as Carter and co-worker sinthetised the proposed structure and observed that the spectroscopic data were not in agreement with those reported by Shimizu. They propose a new structure for Amphidinolide B2, where the two alcohols in C16 and C18 have a syn relative configuration. Our retrosynthesic analysis was based in four main disconnections that lead to four principal fragments. The synthesis of Fragment I has been optimized using a methyl ketone asymmetric allylation of ketones developed by Schaus. In this manner, the synthesis of the fragment could be achieved in 3 steps and 32% overall yield. Fragment II was envisage via an olefination reaction of lactol 1.9. However, this reaction was not trivial and an exhaustive study was carried out. Finally, using Wittig olefination reaction with 0.9 equivalents of ylide or 2.0 equivalents of trifluoroethanol, the product could be obtained. Negishi reaction has also been studied for the Csp3–Csp2 coupling. After several optimizations, we have been able to synthesize Western Fragment with this protocol. Finally, Jørgensen’s catalytic asymmetric epoxidation allowed us to the formation of the α,β-epoxy aldehyde. Taking advantage of the Negishi reaction study performed bellow, we decided to focus our attention in the challenging C15–C16 bond formation of Palmerolide A, a melanoma-inhibiting macrolide. After some studies changing the protecting group, we obtained the coupling product in 78% yield. Fragment IV is the simplest of all. The synthesis starts from γ-butirolactone and sulfone 6.1 is obtained in 4 steps and 53%. This compound was used for the Julia–Kocienski olefination obtaining 6.3 in moderate yield. Unfortunately, we haven’t had enough time to continue with the synthesis, which implies a saponification, sterification of Fragment II, ring-closing metathesis to form the macrolactone and the final directed oxi-Michael adition to obtain the C18 stereogenic center.
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Nie, Yong. "Functionalized nido-C 4 B 2, closo-C 2 B 5 and -C 2 B 10 carboranes, and reactivity studies on electron-poor 2,3-Dihydro-1,3-diborolyl complexes of ruthenium." [S.l. : s.n.], 2005. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11729954.
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石川, 葉留奈, Haruna ISHIKAWA, 佐知子 西田, Sachiko NISHIDA, 智弘 吉田, Tomohiro YOSHIDA, 静代 眞, and Shizuyo SHIN. "髙木蘚苔類コレクションリスト2-2：B で始まる属（2）." 名古屋大学博物館, 2008. http://hdl.handle.net/2237/12218.
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Greiwe, Peter. "Synthese von Heterodiborolanen und Aufbau von nido-Hexaboranen mit den Gerüstatomen C 2 B 3 N, C 2 B 3 S und C 5 B." [S.l. : s.n.], 2000. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB8832639.
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Philips, Julia Rachel. "B-1 and B-2 B cell responses to lipopolysaccharide putative roles in the pathogenesis of periodontitis /." University of Sydney, 2006. http://hdl.handle.net/2123/1852.
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Master of SciencePeriodontal disease is one of the most widespread diseases in humans and is characterised by chronic gingival inflammation and B cell accumulation and resorption of the crest of alveolar bone with subsequent loss of teeth. Porphyromonas gingivalis has been identified as a putative aetiological agent for periodontitis. The aim of the research presented in this thesis was to investigate, using in vitro systems, the responses of autoreactive B-1 and B-2 cells to enterobacterial and nonenterobacterial lipopolysaccharide (LPS) to shed light on the pathogenesis of chronic periodontitis and other diseases involving B cell accumulation and autoantibody production. The hypotheses tested were: (1) B cells respond differently to enterobacterial and non-enterobacterial LPS. (2) B-1 cells are activated by a lower concentration of LPS than B-2 cells. (3) LPS stimulation results in preferential accumulation of B-1 cells. Findings consistent with these hypotheses would provide new evidence for different roles for B-1 and B-2 cells in immune responses and that LPS stimulation could lead to B-1 cell accumulation in diseases thus characterised. Initial experiments investigated the responses of representative B-1 (CH12) and B-2 (WEHI-279) cell lines to preparations of P. gingivalis and Salmonella enteritidis LPS utilising flow cytometric and quantitative molecular methods. The cell lines responded differently to the two LPS preparations. There were significant but limited effects on viability and proliferation in the WEHI-279 cell line, but no significant changes in mRNA expression levels for genes including Toll-like receptors (TLR2, TLR4, RP105), immunoglobulin (IgM), cytokines (IL-6, IL-10), co-stimulatory molecules (CD80, CD86), and regulators of apoptosis (Bcl-2, Bax). In the CH12 cell line however, LPS stimulation had greater effect. Addition of S. enteritidis LPS from a threshold level of 100ng/mL was found to rescue the cells from death, reflected by the percentage viability and proliferation. Stimulation of CH12 cells with S. enteritidis LPS also led to a decrease in expression of RP105 mRNA, which may be part of a negative feedback loop. Interestingly, stimulation with low concentrations P. gingivalis LPS appeared to inhibit proliferation but high LPS concentrations stimulated proliferation of CH12 cells, although no further significant effects were noted in other analyses. Evidence was found that CH12 cells have a high basal level of activation. This suggests that this line is constitutively activated. Stimulation with P. gingivalis or S. enteritidis LPS did not affect the level of CD80 mRNA expression. It is possible that the CH12 line constitutively expresses a maximal level of CD80 (and possibly CD86) and further stimulation will not cause any increase. Since S. enteritidis LPS appeared to have more pronounced effects on both B cell populations, this LPS was used to further investigate B cell subset responses in a mixed splenocyte culture system. Experiments examining percentage viability and number of viable cells indicated that B-1 and B-2 B cells responded differently to LPS stimulation. A threshold level for B-2 cell response (significant increase in cell number) was found to be 100ng/mL LPS, in contrast to the B-1 B cell subset which were only significantly different to the unstimulated cells when stimulated with 50μg/mL LPS. By examining the expression of CD80, the majority of murine splenic B-1 cells were found to activated prior to any LPS stimulation in vitro. In contrast, the B-2 subset showed significant increase in CD80 expression only at high (≥10μg/mL) LPS concentrations. Studies of the division index of B-1 and B-2 cells showed a significant response in both subsets following stimulation with 1μg/mL and 10μg/mL LPS. However, overall, the results are inconsistent with LPS driving the preferential accumulation of B-1 cells in disease states. These experiments provided useful evidence that supported the idea that B-1 and B-2 cells respond differently to LPS. However, these studies were unable to directly address the role of P. gingivalis LPS in periodontitis. It may be that P. gingivalis LPS could have different effects to S. enteritidis LPS on primary B cells. It is still possible that B-1 cells may be more sensitive to P. gingivalis, as opposed to S. enteritidis LPS. Studies by other groups have suggested that the TH1/TH2 profile is skewed towards TH2 in chronic periodontitis and that P. gingivalis may drive this shift via its ability to signal through TLR2 (and modulate TLR4 signalling). Further, recent studies in our laboratories have found that P. gingivalis gingipains are able to polyclonally activate B cells and to break down both IFNγ and IL-12. Future studies should further examine the effects of B-1 and B-2 interactions in the mixed lymphocyte system together with subsequent studies utilising human periodontitis biopsies. The results presented in this thesis, together with work undertaken by other investigators, suggests that LPS could perturb the normal homeostatic mechanisms of the B-1 B cell-subset and increase polyclonal activation therefore contributing to the genesis of pathologies such as chronic periodontitis.
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Margrey, Kaila Ashley. "The Synthesis of 2-Pyridones and Louisianin B." W&M ScholarWorks, 2013. https://scholarworks.wm.edu/etd/1539626720.
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Oh, Chang-Heon. "A Unified Analysis of the B = 2 System." Diss., Virginia Tech, 1997. http://hdl.handle.net/10919/30380.
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Results are presented for a unified analysis
of the reactions pp -> pp. pid -> pid and
pid -> pp over the center-of-mass energy
interval from pion threshold to
approximately 2.4 GeV. These results for
pid -> pp and pid elastic scattering are
superior to previous VPI analyses of these
reactions. In particular, the overall phase in
pid -> pp has now been determined.
Comparisons and predictions are made with
previous (separate and unified) analyses of
this two-baryon system. Several partial
wave amplitudes show resonance-like
behavior in these reactions.Ph. D.
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Altenburg, Detlef, and Rainer Bayreuther. "Musik und kulturelle Identität: Band 2: Symposien B." Bärenreiter Verlag, 2012. https://slub.qucosa.de/id/qucosa%3A71833.
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Campbell, Michelle. "The immunomodulatory role of proteinase activated receptor-2 (PAR-2) in B cells." Thesis, University of the West of Scotland, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627909.
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Proteinase activated receptor-2 (PAR-2) is a seven transmembrane G protein coupled receptor (GPCR) which is activated by proteolytic cleavage to reveal a cryptic tethered ligand (Macfarlane et al, 2001). Whilst PAR-2 expression has been demonstrated in a number of immune related cells (Shpacovitch et al, 2008) and has been shown on human synovial B cells (Busso et al, 2007) however a functional role for the receptor has not been proposed. Previous studies have demonstrated the benefit of PAR-2 antagonism in inflammatory models. Utilising the antagonist ENMD-1068 as a treatment in the collagen induced arthritis (CIA) model resulted in the reduction of clinical disease severity as well as reducing the proportion of splenic B cells compared with vehicle treated mice. PAR-2 was shown to be expressed on B cell progenitors, splenic, bone marrow and peritoneal B cell subsets. Following induction of CIA this expression was up-regulated in the bone marrow Hardy fraction progenitor cells, and the innate like B cell subsets found in the peritoneum, spleen and bone marrow, consistent with up-regulated PAR-2 expression found on T cells and monocytes from patients with rheumatoid arthritis (Crilly et al, 2012b).
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Kuittinen, O. (Outi). "Matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) in hematological malignancies." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:951426942X.
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Abstract
Gelatinases (MMP-2 and MMP-9) play a key role during
invasion and metastazising of malignant cells and they have been
shown to be associated to invasive phenotype and poor prognosis in
several solid tumours. However little is known about their role in
hematological malignancies. In the present work, gelatinase
expression and its clinicopathological correlations were studied
with immunohistochemical staining in 10 cases representing normal
bone marrow aspirate smears, 123 cases representing diagnostic
bone marrow samples of patients with different leukaemias (35 AML,
7 CLL, 6 CML, 75 ALL), 67 diagnostic paraffin-embedded lymph node
biopsies from patients with Hodgkin's lymphoma and 57 biopsies
from patients with non-Hodgkin's lymphomas. The lymphoma samples
were also stained with factor VIII antibody to evaluate the extent
of new vessel formation and the non-Hodgkin's lymphoma cases also
with tissue inhibitor of metalloproteinases -1 (TIMP-1) antibody.
CLL did not express either of the MMP enzymes, while CML in the
chronic phase expressed strongly both of the enzymes. In ALL,
gelatinase expression was weak and detectable in pediatric cases
in only 12.7% and in the adults in 65% of the cases. In adult ALL,
MMP-2 expression correlated strongly with an extramedullary and
invasive pattern of disease presentation. In AML MMP-2 positivity
had markedly favorable prognostic and predictive power. In
lymphoma studies, no correlations could be detected between
gelatinase expression and the clinical parameters of invasion.
MMP-9 positivity was related to the presence of B symptoms, which
difference was statistically significant in Hodgkin's lymphoma. In
Hodgkin's lymphoma, strong MMP-9 expression also implicated
decreased neovascularization. In both lymphoma types, strong MMP-9
expression correlated with unfavorable prognosis, which difference
was statistically significant in non-Hodgkin's lymphomas and
remained as a tendency in Hodgkin's lymphoma. MMP-2 had
statistically significant association with a favorable prognosis
in Hodgkin's lymphoma. Combination of the results of both
stainings further increased prognostic power. All together these
findings implicate that gelatinases could be used as prognostic
tools in AML and lymphomas albeit this needs to be verified in
larger materials.
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François-Bendahou, Christine. "Etude de combinaisons synergiques d'anticorps monoclonaux anti-chaine a et b du recepteur a l'il2 et d'un anticorps bispecifique anti-a/anti-b : production d'une chaine b soluble et developpement d'anticorps monoclonaux anti-chaine b." Nantes, 1994. http://www.theses.fr/1994NANT02VS.
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Ceizar, Maheen. "B-cell Lymphoma-2 (Bcl-2) Is an Essential Regulator of Adult Hippocampal Neurogenesis." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23287.
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Of the thousands of dividing progenitor cells (PCs) generated daily in the adult brain only a very small proportion survive to become mature neurons through the process of neurogenesis. Identification of the mechanisms that regulate cell death associated with neurogenesis would aid in harnessing the potential therapeutic value of PCs. Apoptosis, or programmed cell death, is suggested to regulate death of PCs in the adult brain as overexpression of B-cell lymphoma 2 (Bcl-2), an anti-apoptotic protein, enhances the survival of new neurons. To directly assess if Bcl-2 is a regulator of apoptosis in PCs, this study examined the outcome of removal of Bcl-2 from the developing PCs in the adult mouse brain. Retroviral mediated gene transfer of Cre into adult floxed Bcl-2 mice eliminated Bcl-2 from developing PCs and resulted in the complete absence of new neurons at 30 days post viral injection. Similarly, Bcl-2 removal through the use of nestin-induced conditional knockout mice resulted in reduced number of mature neurons. The function of Bcl-2 in the PCs was also dependent on Bcl-2-associated X (BAX) protein, as demonstrated by an increase in new neurons formed following viral-mediated removal of Bcl-2 in BAX knockout mice. Together these findings demonstrate that Bcl-2 is an essential regulator of neurogenesis in the adult hippocampus.
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Kootz, Andreas. "B-Identifikation im Level-2-Trigger des ATLAS-Experiments." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=97677724X.
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Trottmann, Martin. "2-Cyanbenzyl-Derivate zum Aufbau von Vitamin B₁₂-Modellverbindungen /." [S.l : s.n.], 1986. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
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Barnes, Suzanne R. "Size Exclusion Chromatography of Poly(2-ethyl-2-oxazoline) Homopolymers and Poly(ethylene oxide)-b-Poly(2-ethyl-2-oxazoline) Copolymers." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/24907.
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Size exclusion chromatography is the method of choice for characterizing molecular weights and molecular weight distributions of polymers. An important advancement in SEC is multidetection SEC which includes multi-angle laser light scattering, viscometry, refractive index and UV spectroscopy to analyze block and graft copolymers as well as polymers with oligomeric molecular weights. Oligomeric molecular weights present special challenges since the light scattering and viscosity detectors are more sensitive to higher molecular weights and both detectors have low molecular weight threshold values.
The molecular weights and distributions of poly(2-ethyl-2-oxazoline) oligomers and block copolymers as well as poly(2-ethyl-2-oxazoline) were investigated by SEC using multiple detectors. Both a universal calibration method and light scattering were used to determine molecular weights and molecular weight distributions. The solvent was N-methylpyrrolidone that contained 0.05M LiBr used to minimize interactions among the polymers and solvent. SEC was used to establish that the diblock copolymers had heterogeneous compositional distributions. The low molecular weights of the diblock and homopolymer made it necessary to use the universal calibration method with combined refractive index and viscometry detectors to determine absolute molecular weights.Master of Science
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Hastings, William David. "Peritoneal B-2 cells comprise a distinct population that differentiates to a B-1b phenotype /." Citation, abstract and full text online, 2005. http://proquest.umi.com.ezproxy.bu.edu/pqdweb?did=913526461&sid=2&Fmt=2&clientId=374&RQT=309&VName=PQD.
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Guliyeva, Aynur. "Nanostructuration de terpoymères triblocs linéaires poly(isoprène-b-styrène-b-2-vinylpyridine) en film mince." Thesis, Orléans, 2019. http://www.theses.fr/2019ORLE3026.
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Dans cette thèse, nous nous sommes attachés à préparer des films minces nanostructurés à partir de copolymères à blocs et de les caractériser par différentes techniques (AFM, MET et GISAXS). Le but de la recherche est de réaliser des nanostructurations originales en films minces afin de prendre en compte l'effet de confinement (quantité de matière limitée, interaction avec la surface ...) et de comprendre les phénomènes se produisant au cours de la structuration. Les travaux ont porté sur la mise en œuvre des films minces, leur réorganisation sous vapeur de solvant et leur caractérisation.Plus spécifiquement, les travaux de thèse ont porté sur l’étude de copolymères triblocs linéaires ISP (PI-b-PS-b-P2VP) (seuls ou en mélanges) en films minces, déjà étudié en volume par un laboratoire partenaire de l’Université de Nagoya. Nous avons développé des méthodes de caractérisation adaptées à ce polymère en film mince, en particulier une technique originale de GISAXS reposant sur le marquage sélectif des blocs par des éléments lourds (iode, osmium). Ceci nous a permis de confirmer la structure interne et la forme de l’interface (rayon de courbure) des domaines minoritaires, d’observer des transitions structurales originales. La présence de couches de mouillage aux deux interfaces du film (film/air et film/substrat) est une caractéristique commune à tous les systèmes.Tout d’abord, des triblocs seuls, se trouvant à la limite des différentes morphologies sur le diagramme de phase, ont été étudiés en film mince. Contrairement à ce qui a été observé en volume, des transitions structurales (CYL-SPH et GYD-CYL) ont été observées. Notamment, la transition d’une structure gyroïde alternée présentant une symétrie Q214 vers des cylindres avec une symétrie P2mm (pas d’arrangement typique hexagonal) représente, pour des terpolymères triblocs, un des résultats majeurs de la thèse. Le mécanisme de transition structurale a été élucidé par différentes techniques de caractérisation montrant une relation d’épitaxie entre les deux phases. Ensuite, nous nous sommes focalisés sur la nanostructuration de mélanges de triblocs. Nous avons montré la possibilité d’obtenir des domaines minoritaires de PI et P2VP présentant des interfaces rectangulaires, arrangés avec une symétrie tétragonale, ouvrant la voie à des applications potentielles dans le domaine de nanolithographieIn this thesis, we focused on preparing nanostructured thin films from block copolymers and characterizing them by different techniques (AFM, TEM and GISAXS). The goal of the research is to produce original nanostructuration in thin films in order to consider the effect of confinement (limited amount of matter, interaction with surface ...) and to understand the phenomena occurring during structuration. The work includes the elaboration of thin films, their reorganization under solvent vapor and their characterization.Specifically, the thesis focused on the study of ISP linear triblock copolymers (PI-b-PS-b-P2VP) (neat or in blends) in thin films, already studied in volume by a partner laboratory of the Nagoya University. We developed adapted characterization methods to this type of polymer in thin film, such as an original method of GISAXS based on the selective staining of blocks by heavy elements (iodine, osmium). This allowed us to confirm the internal structure and the shape of interface of the minority domains and to observe original transitions between morphologies. The presence of wetting layers at both film interfaces (film / air and film / substrate) is a common feature for all systems.Firstly, neat triblocks located on the boundary between different morphologies on the phase diagram, were studied in thin film. Contrary to what was observed in volume, structural transitions (CYL-SPH and GYD-CYL) were observed in thin film. Particularly, the transition from an alternating gyroid structure having a Q214 symmetry to cylinders with symmetry P2mm (no typical hexagonal arrangement) represents, for triblock terpolymers, one of the major results of the thesis. The structural transition mechanism was elucidated by different characterization techniques showing an epitaxial relationship between the two phases. Secondly, we focused on the nanostructuration of triblock blends. We showed the possibility to obtain minority domains of PI and P2VP with rectangular interfaces, arranged with tetragonal symmetry, opening the way for potential applications in the field of nanolithography
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Vasconcelos, Zanair Soares. "Avaliação do potencial anticâncer do derivado benzotiazólico (E)-2-((2-(benzo[d]tiazo-2-ila)hidrazono)metil)-4-nitrofenol em células de melanoma humano." Universidade Federal do Amazonas, 2013. http://tede.ufam.edu.br/handle/tede/2574.
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Previous issue date: 2013-08-30CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Malignant melanoma is one of the few cancers has been increasing in prevalence and mortality worldwide. It affects mainly white populations, however, all ethnic groups are affected to some extent. Increased understanding of the causes, progression, and in particular, genes that affect the development of cancer enable improvements in tools for detecting and treating cancer, however, despite significant advances in understanding the biology of melanoma, no changes in practices involved in both approaches and therapies to treat advanced disease. Thus, malignant melanoma has been intensively investigated due to its high metastatic potential. Many patients, when diagnosed with metastatic melanoma have already, which is the leading cause of death among them. This tumor is almost insensitive to standard regimens of chemotherapy, and the chemotherapeutic agents available are limited. Some mutations are known in cutaneous melanomas and N-Ras, Tp16 and Tp53, however, changes in B-Raf significantly exceed the frequency of the other mutations (40-50%). In this context, this project explored the possible mechanisms of action of the derivative benzotiazólico (E)-2-((2-(Benzo[d] thiazole-2-ila)hydrazono) methyl)-4-nitrophenol on cell viability, the activity clonogenic, motility and invasiveness in melanoma cell lines SK-Mel-19, SK-Mel-28 and SK-Mel-103 that have different characteristics from mutations in the genes responsible for the control of cellular homeostasis, as Tp53 and B-Raf. The results of tests performed showed an IC50 at 72hours between (4.87and>10 um) and a possible selective toxicity to the gene mutated B-Raf. Other tests showed induction of cell death by apoptosis, impaired motility and invasiveness of cells treated with SK-Mel benzotiazolic derivative (E)-2-((2-(Benzo[d]thiazole-2-Ila)hydrazono)methyl)-4-nitrophenol. The obtained results make this target compound for more research to use against cancer.
O melanoma maligno é um dos poucos cânceres que vem aumentando em prevalência, bem como taxa de mortalidade em todo o mundo. Afeta principalmente populações brancas, no entanto, todos os grupos étnicos são afetados em alguma proporção. Os avanços na compreensão das causas, progressão e, em particular, dos genes que afetam o desenvolvimento do câncer possibilitam melhorias nas ferramentas para a detecção e tratamento câncer, no entanto, apesar dos avanços significativos na compreensão da biologia do melanoma e das abordagens para tratar a doença em estágio avançado agora se voltarem para inibidores de genes envolvidos nessa doença, houve poucas mudanças aprovadas nas terapias utilizadas. Assim, o melanoma maligno vem sendo intensamente investigado devido ao seu elevado potencial metastático. Muitos pacientes, ao serem diagnosticados com melanoma já tem metástases, o que é a principal causa de morte entre eles. Este tipo de tumor é quase insensível ao regime padrão de quimioterapia, e os agentes quimioterapêuticos disponíveis são limitados. Algumas mutações são conhecidas nos melanomas cutâneos como N-Ras, Tp16 e Tp53, entretanto, mutações em B-Raf excedem significativamente a frequência de outras mutações (40-50%). Nesse contexto, tratamentos mais eficazes são necessários e na constante busca por novos compostos, os derivados benzotiazólicos mostram-se como uma importante alternativa, já que tem sido apontados como possíveis agentes antitumorais. Nesse sentido, este projeto explorou os possíveis mecanismos de ação do derivado benzotiazólico (E)-2-((2-(Benzo[d]tiazo-2-ila)hidrazono)metil)-4-nitrofenol sobre a viabilidade celular, a atividade clonogênica, a motilidade e a capacidade invasiva em linhagens celulares de melanoma SK-Mel-19, SK-Mel-28 e SK-Mel-103 que possuem diferentes características de mutações nos genes responsáveis pelo controle da homeostasia celular, como Tp53 e B-Raf. Os resultados dos ensaios executados revelaram um CI50 em 72 horas entre (4,87 e >10 μM) e uma possível toxicidade seletiva para o gene B-Raf mutado. Outros testes evidenciaram indução de morte celular por apoptose, diminuição da motilidade e da capacidade invasiva das células SK-Mel tratadas com derivado benzotiazólico (E)-2-((2-(Benzo[d]tiazo-2-ila)hidrazono)metil)-4-nitrofenol. Os resultados obtidos tornam este composto alvo de mais pesquisas para sua utilização contra o câncer.
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Tong, Jin. "Homo- and Mixed-valence [2 × 2] Grid Complexes." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://hdl.handle.net/11858/00-1735-0000-0028-8736-B.
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Haapalainen, A. (Antti). "Structure-function studies of the mammalian peroxisomal multifunctional enzyme type 2 (MFE-2)." Doctoral thesis, University of Oulu, 2002. http://urn.fi/urn:isbn:9514268385.
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Abstract
Mammalian peroxisomes contain two parallel multifunctional enzymes (MFE), MFE type 1 and MFE type 2 (MFE-2), which are responsible for the degradation of fatty acids. They both catalyze the second and third reactions of the β-oxidation pathway, but through reciprocal stereochemical courses. MFE-2 possesses (2E)-enoyl-CoA hydratase-2 and (3R)-hydroxyacyl-CoA dehydrogenase activities. In addition, the carboxy-terminal part is similar to the sterol carrier protein type 2 (SCP-2).
The purpose of this work was to study the structure-function relationship of functional domains of mammalian MFE-2 by recombinant DNA technology, enzyme kinetics and X-ray crystallography. The work started with the identification of conserved regions in MFE-2. This information was utilized when dehydrogenase, hydratase-2 and/or SCP-2-like domain were produced as separate recombinant proteins. Subsequently, both dehydrogenase and SCP-2-like domains were crystallized and their crystal structures were solved.
The structure of the dehydrogenase region of rat MFE-2 contains the basic α/β short-chain alcohol dehydrogenase/reductase (SDR) fold and the four-helix bundle at the dimer interface, which is typical of dimeric SDR enzymes. However, the structure has a novel carboxy-terminal domain not seen among the known structures. This domain lines the active site cavity of the neighbouring monomer, reflecting cooperative behaviour within a homodimer.
The monomeric SCP-2-like domain of human MFE-2 has the same fold as rabbit SCP-2. The structure includes a hydrophobic tunnel occupied by an ordered Triton X-100 molecule, demonstrating the ligand-binding site. Compared to the unliganded rabbit SCP-2 structure, the position of the carboxy-terminal helix is different. The movement of this helix in the liganded human SCP-2-like domain resulted in the exposure of a peroxisomal targeting signal, suggesting ligand-assisted protein import into peroxisomes.
The roles of conserved protic residues in the hydratase-2 region of human MFE-2 were studied by mutating them to alanine. In the first step, the ability of mutated variants to utilize oleic acid in vivo was tested with Saccharomyces cerevisiae fox-2 cells (devoid of endogenous MFE-2). Subsequently, in vitro characterization of the mutant enzymes revealed two amino acid residues, Glu366 and Asp510, vital for hydratase-2 activity. The results indicate that the acid-base catalysis is valid for hydratase-2.
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Grosse, Sandrine. "Imidazo[1, 2-b]pyrazoles, imidazo[1, 2-a]imidazoles : synthèse, fonctionnalisation et évaluation biologique." Thesis, Orléans, 2013. http://www.theses.fr/2013ORLE2056.
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Les imidazo[1,2-b]pyrazoles tout comme les imidazo[1,2-a]imidazoles sont des entités présentant diverses applications intéressantes notamment dans le domaine pharmacologique. Cependant, malgré ce potentiel, ces structures hétérobicycliques ont été, jusqu’à ce jour, relativement peu étudiées tant au niveau de leur préparation que de leur fonctionnalisation. De ce fait, ces travaux de thèse ont pour objet la mise au point de nouvelles voies d’accès à ces systèmes bicycliques et ce, au départ de substrats facilement accessibles. Des stratégies de fonctionnalisation de ces charpentes moléculaires ont ensuite été développées dans le but de concevoir des librairies diversifiées de ce type de composés, librairies destinées à être évaluées biologiquement. Les premiers résultats d’évaluation sur des lignées cancéreuses de dérivés imidazo[1,2-b]pyrazoliques sont également présentésImidazo[1,2-b]pyrazoles and imidazo[1,2-a]imidazoles are entities with some interesting applications in pharmacology. However, despite this potential, few methods of preparation and direct functionalisation of the heterocyclic moiety have been described. In this context, the overall goal of our research is to develop new routes to these bicyclic systems from readily available starting materials. Strategies of functionalisation of the heterocyclic moiety were then explored in order to design diversified libraries for the evaluation of potential biological activities. Herein, the results of the tests of imidazo[1,2-b]pyrazole series against various cancer lines are reported
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Álvarez, Hernández Lucía [Verfasser], and Ingo [Akademischer Betreuer] Krossing. "Li[B(OCH(CF3)2)4] - Synthesis optimization and characterization of its Electrolytes = Li[B(OCH(CF3)2)4] - Syntheseoptimierung und Charakterisierung dessen Elektrolyte." Freiburg : Universität, 2013. http://d-nb.info/1123481563/34.
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Diril, Muhammed Kasim. "Genetic analysis of stoned B-stonin 2 function in vivo." [S.l.] : [s.n.], 2005. http://webdoc.sub.gwdg.de/diss/2005/diril/diril.pdf.
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Garrett, Joan Teresa. "Peptide-based B-cell epitope vaccines targeting HER-2/neu." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1189103626.
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Bevitt, Debra Jane. "Studies on 6-deoxyerythronolide B synthase 2 from Saccharopolyspora erythraea." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281909.
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Sherwood, Tracy. "Characterization of Cannabinoid Receptor 2 Transcript Expression in B Cells." Scholar Commons, 2010. https://scholarcommons.usf.edu/etd/1767.
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Cannabinoids and cannabinoid receptors have been shown to play important roles in immune regulation particularly as modulators of anti-inflammatory cytokines and antibody production. The predominant cannabinoid receptor involved in this immune regulation is cannabinoid receptor 2 (CB2), which is robustly expressed in B cells. Utilizing a combination of bioinformatics, 5' RACE, real time RT-qPCR, and reporter assays, we showed that human B cells from peripheral blood mononuclear cells (PBMC) expressed one CB2 transcript while mouse B cells from spleen express three CB2 transcripts. Alignment of the sequenced B cell RACE products to either the mouse or human genome, along with the GenBank mRNA sequences, revealed that the transcripts isolated in this study contained previously unidentified transcriptional start sites (TSSs). In addition, expression construct testing of the genomic region containing the TSSs of the mouse CB2 exon 1 and 2 transcripts showed a significant increase of promoter activity. Bioinformatics analysis for cis-sequences in the promoter regions identified DNA binding sites for NF-kB, STAT6, and Elk1 transcription factors activated by LPS, IL-4 and anti-CD40. Regarding variations in CB2 transcript expression among the immune cell subtypes, RACE analysis showed that the exon 1b transcript is seen in B cells but not in T cells, dendritic cells or macrophages. Furthermore, RT-qPCR showed variations in transcript expression during B cell development as well as in resting versus LPS or IL-4/anti-CD40 stimulated B cells. The exon 1a transcript was predominant in pre-, immature and resting B cells whereas the exon 1b and 2 transcripts were enhanced in mature and activated B cells. These data showed for the first time that human B cells use one TSS for CB2 expression while mouse B cells use multiple TSSs for the expression of three CB2 transcripts, in which the expression of the individual transcript is related to immune cell type and/or cell activation state. Additionally, this is the first report in mouse B cells defining TSSs that are in genomic areas with promoter activity thus suggesting the location of two promoter regions. Defining the CB2 transcript expression during various stages of B cell activation provide clues to therapeutic methods.
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Garrett, Joan T. "Peptide-based B-cell epitope vaccines targeting HER-2/neu." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1189103626.
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Kanmacher, Isabelle. "Les substances alpha-2 adrenergiques : pharmacochimie d'isoquino 1, 2-b quinazolines et d'(amino-2 benzyl)-2 tetrahydro-1, 2, 3, 4 isoquinoleines aux proprietes alpha-antagonistes." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13250.
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Schwarzhans, Dirk. "Hochauflösende Laserspektroskopie der elektronischen Zustände X2S [X 2 Sigma], A2p [A 2 Pi] und B2S [B 2 Sigma] von Natrium-Argon." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=960354166.
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Nixon, Douglas A. "A seventeenth-century house at Ferryland, Newfoundland (CgAf-2, Area B)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ54944.pdf.
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Gombert, Wendy Marie. "Transcriptional regulation of the bcl-2 gene in human B cells." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312464.
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Thomenius, Michael James. "B-CELL LYMPHOMA-2 PROTEIN FAMILY, APOPTOSIS AND THE ENDOPLASMIC RETICULUM." Case Western Reserve University School of Graduate Studies / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=case1080679967.
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Goh, Fui Goon. "The regulation of nuclear factor kappa B (NFkB) activation mediated by proteinase-activated receptor-2 (PAR-2)." Thesis, University of Strathclyde, 2006. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21653.
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Proteinase-activated receptor-2 (PAR-2) is the second member of the new subfamily of G-protein coupled receptors with a novel mode of mechanism of activation. As with other family members, PAR-2 is activated through the proteolytic cleavage of the amino terminal of the receptor, thus un-masking a tethered ligand which then binds to the receptor causing intramolecular activation. Serine proteases such as trypsin and tryptase serve as the predominant endogenous activators for PAR-2, whilst synthetic activating peptides derived from the tethered ligand sequence are also able to stimulate receptor activation without proteolysis. The expression of PAR-2 has been detected in a variety of human tissues and receptor activation has been shown to mediate diverse biological functions including haemostasis and inflammation. However, the signalling mechanisms underlying PAR-2-induced cellular effects remain largely undefined. Thus this study sought to determine the signalling events following PAR-2 stimulation in NCTC-2544 skin cell line stably expressing PAR-2 and normal human epidermal keratinocytes, in particular the activation of NFкB. Initially PAR-2 was demonstrated to activate NFкB at the levels of IкBα loss, p65 NFкB phosphorylation, DNA binding and transcriptional activation. PAR-2 was also found to stimulate the three major MAP kinases, namely ERK, p38 MAPK and JNK. In addition, this study has included the work to examine the effects of putative PAR-2 inhibitors; K-14585 and ENMD-1068. K-14585 was a weak antagonist in some assay systems but not others, whilst ENMD-1068 was ineffective. The intermediates upstream in the NFYB pathway stimulated by PAR-2 were assessed. Phosphorylation of p65 NFкB was found to be dependent upon Gαq/₁₁, PKC isoforms, calcium mobilisation and IKKP. Interestingly, the inhibition of Gαq/₁₁, activity did not affect NFкB-DNA binding but partially suppressed NFкB-driven transcription. These findings point to the differential regulations of these intermediary components on different levels of NFкB activation mediated by PAR-2.
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Schilcher, Jochen. "Hightech-spezifische Kunden-Unsicherheiten : Adaption technologischer Innovationen als Marketing-Herausforderung für Hightech-Ventures auf B-2-B Märkten /." [S.l.] : [s.n.], 2005. http://www.gbv.de/dms/zbw/503134392.pdf.
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Hallé, Stéphanie. "Caractérisation pharmacologique des récepteurs B(1) et B(2) des kinines chez le hamster consanguin témoin et cardiomyopathique." Sherbrooke : Université de Sherbrooke, 2000.
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Hein, Martin. "Regioselektive elektrophile Substitution von Decaboran B 10 H 14 : Darstellung und Reaktionsverhalten von B 9 Cl 9 und H 2 B 9 Cl 9 /." [S.l. : s.n.], 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10277650.
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Kanmacher, Isabelle. "Les Substances alpha-2 adrénergiques pharmacochimie d'isoquino [1,2-b] quinazolines et d'(amino-2 benzyl)-2 tétrahydro-1,2,3,4 isoquinoléines aux propriétés alpha-antagonistes /." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37614668t.
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Osterhoff, Martin. "Die Rolle der Ca2+/calmodulinabhängigen Proteinkinase II d2 [delta 2] in [beta]-Zellen [Beta-Zellen]." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963854593.
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Rodriguez, Rosie. "A study of the regulation of PLC 2 in B-cell signalling." Thesis, Institute of Cancer Research (University Of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404608.
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Coope, Helen Jane. "Analysis of the regulation of NF#kappa#B by TPL 2 kinase." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249176.
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Vieira, Otávio Augusto Ruiz Paccola [UNESP]. "Geologia da folha guapiara 1:50000 (SG-22-X-B-II-2)." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/150504.
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A Folha Topográfica de Guapiara 1: 50000 (SG-22-X-B-II-2) situa-se no extremo sul do estado de São Paulo e compreende na porção central da Província Mantiqueira a faixa centro-sul do Cinturão Ribeira. O arcabouço geológico local envolve rochas da sequência metavulcanossedimentar do Supergrupo Açunguí, de idade meso- a neoproterozoicas metamorfizadas e deformadas no Neoproterozoico, associadas a rochas granitoides gerados durante os episódios colisionais ligados ao Ciclo Brasiliano e à formação do Supercontinente Gondwana. Na região, oito unidades litoestratigráficas principais foram mapeadas: metassedimentos da Formação Água Clara e dos grupos Votuverava e Itaiacoca de idade meso- a neoproterozoica, corpos graníticos neoproterozoicos representantes do Granito Três Córregos, corpos graníticos neoproterozoicos a cambrianos do Granito Capão Bonito, rochas sedimentares do Grupo Itararé, intrusivas básicas associadas a Formação Serra Geral e sedimentos recentes Quaternários. O quadro estruturalmetamórfico é determinado dominantemente pelo arranjo tectônico final neoproterozóico, evidenciado nas rochas epimetamórficas por uma evolução estrutural do tipo polifásica. As estruturas primárias S0, devido aos intensos processos de transposição das foliações dúctil e deformação milonítica, apresentamse preservadas de forma escassa em algumas áreas, com predomínio somente do acamamento gradacional reliquiar S0, nas áreas menos deformadas, a um bandamento tectônico nas regiões da zona de cisalhamento. São registradas quatro fases deformacionais e três metamórficas principais: a fase Dn, de baixo a médio ângulo e direção preferencial NE/SW, subparalela ao bandamento composicional S0; a fase Dn+1, de baixo a médio ângulo e direção preferencial NW/SE; a fase Dn+2, de alto ângulo e direção preferencial NE/SW, sendo esta fase a mais penetrativa e a principal e a fase Dn+3, de alto ângulo e direção preferencial NW/SE. Os eventos metamórficos associados são caracterizados pelo metamorfismo M1, o ápice metamórfico, do tipo regional progressivo na fácies xisto-verde alto a anfibolito baixo; M2, do tipo de contato em condições de baixa pressão e baixa a média temperatura, com a formação de hornfels e skarns locais; M3 metamorfismo regional regressivo na fácies xisto-verde baixa.
The Topographic Sheet of Guapiara 1: 50000 (SG-22-X-B-II-2) is located in the southernmost part of the state of São Paulo and comprises the central portion of the Mantiqueira Province, the central-southern belt of the Ribeira Belt. The local geological framework involves rocks from the metavulcanosedimentary sequence of the Açunguí Supergroup, meso to neoproterozoic metamorphosed age and deformed in the neoproterozoic, associated with granitoid rocks generated during the collisional episodes related to the Brasilian Cycle and to the formation of the Gondwana Supercontinent. In the region, eight main lithostratigraphic units were mapped: metasediments of the Água Clara Formation and the Votuverava and Itaiacoca Groups of meso-neoproterozoic age, neoproterozoic granite bodies representing the Três Córregos Granite, granite neoproterozoic bodies of the Capão Bonito Granite, sedimentary rocks of Itararé Group, basic effusives rocks associated with the Serra Geral Formation and recent sediments of the Quaternary. The structuralmetamorphic framework is dominantly determined by the final neoproterozoic tectonic arrangement, evidenced in the epimetamorphic rocks by a structural evolution of the polyphase type. The primary structures S0, due to the intense processes of transposition of ductile foliations and milonite deformation, are sparsely preserved in some areas, with predominance only of the relic gradation bedding of S0, in less deformed areas, to a tectonic banding in the regions of Shear Zone. Four deformational phases and three main metamorphic phases are recorded: the Dn phase, low to medium angle and preferential direction NE / SW, which is subparallel to the compositional bandage S0; The Dn + 1 phase, from low to medium angle and preferential direction NW / SE; The phase Dn + 2, of high angle and preferential direction NE / SW, this being the most penetrative and the main phase and the Dn + 3 phase, of high angle and preferential direction NW / SE. The associated metamorphic events are characterized by the metamorphism M1, the metamorphic apex, of the regional progressive type in the high greenschist to low amphibolite facies; M2, contact type under low pressure conditions and low to medium temperature, with the formation of hornfels and local skarns; M3, regressive regional metamorphism in low greenschist facies.
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Vieira, Otávio Augusto Ruiz Paccola. "Geologia da folha Guapiara 1:50000 (SG-22-X-B-II-2) /." Rio Claro, 2017. http://hdl.handle.net/11449/150504.
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Anexo 1 mapaOrientador: Antonio Misson Godoy
Banca: Washington Barbosa Leite Junior
Banca: Jefferson Cassu Manzano
Resumo: A Folha topográfica de Guapiara 1: 50000 (SG-22-X-B-II-2) situa-se no extremo sul do estado de São Paulo e compreende na porção central da Província Mantiqueira a faixa centro-sul do Cinturão Ribeira. O arcabouço geológico local envolve rochas da sequência metavulcanossedimentar do Supergrupo Açunguí, de idade meso- a neoproterozoicas metamorfizadas e deformadas no Neoproterozoico, associadas a rochas granitoides gerados durante os episódios colisionais ligados ao Ciclo Brasiliano e à formação do Supercontinente Gondwana. Na região, oito unidades litoestratigráficas principais foram mapeadas: metassedimentos da Formação Água Clara e dos grupos Votuverava e Itaiacoca de idade meso- a neoproterozoica, corpos graníticos neoproterozoicos representantes do Granito Três Córregos, corpos graníticos neoproterozoicos a cambrianos do Granito Capão Bonito, rochas sedimentares do Grupo Itararé, intrusivas básicas associadas a Formação Serra Geral e sedimentos recentes Quaternários. O quadro estruturalmetamórfico é determinado dominantemente pelo arranjo tectônico final neoproterozóico, evidenciado nas rochas epimetamórficas por uma evolução estrutural do tipo polifásica. As estruturas primárias S0, devido aos intensos processos de transposição das foliações dúctil e deformação milonítica, apresentamse preservadas de forma escassa em algumas áreas, com predomínio somente do acamamento gradacional reliquiar S0, nas áreas menos deformadas, a um bandamento tectônico nas re... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The Topographic Sheet of Guapiara 1: 50000 (SG-22-X-B-II-2) is located in the southernmost part of the state of São Paulo and comprises the central portion of the Mantiqueira Province, the central-southern belt of the Ribeira Belt. The local geological framework involves rocks from the metavulcanosedimentary sequence of the Açunguí Supergroup, meso to neoproterozoic metamorphosed age and deformed in the neoproterozoic, associated with granitoid rocks generated during the collisional episodes related to the Brasilian Cycle and to the formation of the Gondwana Supercontinent. In the region, eight main lithostratigraphic units were mapped: metasediments of the Água Clara Formation and the Votuverava and Itaiacoca Groups of meso-neoproterozoic age, neoproterozoic granite bodies representing the Três Córregos Granite, granite neoproterozoic bodies of the Capão Bonito Granite, sedimentary rocks of Itararé Group, basic effusives rocks associated with the Serra Geral Formation and recent sediments of the Quaternary. The structuralmetamorphic framework is dominantly determined by the final neoproterozoic tectonic arrangement, evidenced in the epimetamorphic rocks by a structural evolution of the polyphase type. The primary structures S0, due to the intense processes of transposition of ductile foliations and milonite deformation, are sparsely preserved in some areas, with predominance only of the relic gradation bedding of S0, in less deformed areas, to a tectonic banding in the regio... (Complete abstract click electronic access below)
Mestre
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Scuderi, Richard. "G1-phase cyclin expression in neoplastic B cells /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-292-2/.
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Larrivée, Jean-François. "Étude de la régulation des récepteurs B¦1 et B¦2 des kinines et caractérisation pharmacologique de nouveaux antagonistes du récepteur B¦1 chez le lapin." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ60774.pdf.
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Keily, John Fraser. "Part A: [2+2] cycloadditions of keteniminium salts with resin bound alkenes : Part B: Permanganate oxidations of 1,5-dienes." Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271633.
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