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Journal articles on the topic 'SKG'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Napier, Ruth J., Ellen J. Lee, Emily E. Vance, et al. "Nod2 is a negative regulator of arthritogenic T cell responses in SKG mice." Journal of Immunology 200, no. 1_Supplement (2018): 162.1. http://dx.doi.org/10.4049/jimmunol.200.supp.162.1.

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Abstract Nod2 is a pattern recognition receptor known for its role in antimicrobial immunity. Intriguingly, NOD2 appears to have a role outside of infection, as a single point mutation in this molecule leads to 100% incidence of an inflammatory arthritis called Blau Syndrome. Here we investigate the role of Nod2 in regulation of arthritogenic CD4+ T cells in SKG mice. SKG mice have a mutation in ZAP-70 that results in altered thymic selection and spontaneous production of arthritogenic T cells. Nod2−/− SKG mice have exacerbated arthritis and increased numbers of CD4+IL-17+ (Th17) cells that co

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Feldman, Hans-Uli. "Neues aus der SKG." KN - Journal of Cartography and Geographic Information 53, no. 4 (2003): 189–92. http://dx.doi.org/10.1007/bf03544979.

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Boroojeni, Shaghayegh Foroozan, Akihiro Nakamura, Mansi Aparnathi, Mariia Korshko, and Nigil Haroon. "Macrophage Migration Inhibitory Factor and Hypoxia-Inducible Factor 1-Alpha May Play a Role in Maintaining Intestinal Homeostasis Through Regulation of Occludin and Claudin-1 Expression." Journal of Rheumatology 52, Suppl 2 (2025): 42.1–42. https://doi.org/10.3899/jrheum.2025-0314.1.

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ObjectivesAxial spondyloarthritis (axSpA) is a chronic inflammatory condition mainly impacting the musculoskeletal system. The majority of axSpA patients experience gut inflammation, with 60% having microscopic changes and 10% having overt inflammatory bowel disease (IBD). Over the years, researchers have linked many pathways and cell populations to the pathogenesis of gut inflammation in axSpA. One notable player may be the macrophage migration inhibitory factor (MIF), a crucial factor in axSpA development. In a SpA mouse model (SKG mice), MIF overexpression mirrors key clinical features of a

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Napier, Ruth J., Emily E. Vance, Ellen J. Lee, and Holly L. Rosenzweig. "Card9 promotes pathogenic neutrophil responses that induce Th17-mediated autoimmune arthritis and spondylitis." Journal of Immunology 206, no. 1_Supplement (2021): 60.11. http://dx.doi.org/10.4049/jimmunol.206.supp.60.11.

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Abstract Caspase recruitment domain-containing protein 9 (Card9) promotes anti-fungal immunity following C-type lectin receptor Dectin-1 activation by b-glucans. CARD9 has also been implicated in the pathogenesis of T cell-mediated inflammatory diseases including rheumatoid arthritis and ankylosing spondylitis, but how Card9 controls non-infectious inflammation is poorly understood. Using genetically susceptible SKG mice that develop b-glucan (zymosan)-induced, Th17-mediated autoimmune arthritis and spondylitis we found that Card9-deficiency (Card9−/− SKG mice) conferred complete protection fr

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Rahman, M. Arifur, and Ranjeny Thomas. "The SKG model of spondyloarthritis." Best Practice & Research Clinical Rheumatology 31, no. 6 (2017): 895–909. http://dx.doi.org/10.1016/j.berh.2018.07.004.

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Dragone, Leonard, Laura A. Shaw, Kristen K. Rumer, Anita Kramer, Shimon Sakaguchi, and Virginia D. Winn. "Pregnancy-Induced Rheumatoid Arthritis Amelioration in SKG Mice (137.29)." Journal of Immunology 182, no. 1_Supplement (2009): 137.29. http://dx.doi.org/10.4049/jimmunol.182.supp.137.29.

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Abstract Background: During pregnancy 75% of women with Rheumatoid Arthritis (RA) have amelioration of their disease. The mechanism of pregnancy-induced amelioration of RA is poorly understood. A mouse model of RA has been characterized (SKG). SKG mice have a spontaneous mutation in ZAP-70 and a single dose of zymosan induces arthritis. To determine if the SKG model is valid for studying the effects of the immune system on RA amelioration, we looked at whether remitted arthritis in SKG mice. Methods: Cohorts of SKG mice were treated with zymosan (Z, n=17), zymosan plus pregnancy (Z+P, n=6), pr

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Kubota, Hidekazu, Satoshi Nomura, Yasuyuki Sumi, and Toyoaki Nishida. "Sustainable Memory System Using Global and Conical Spaces." JUCS - Journal of Universal Computer Science 13, no. (2) (2007): 135–48. https://doi.org/10.3217/jucs-013-02-0135.

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We present a concept and implementation of a computational support for spatial memory management and describe its temporal evolution. Our essential idea is to use an immersible globe that consists of a global space and a conical space, thereby providing arbitrary memory space for humans. We developed a sustainable knowledge globe (SKG) for constructing a memory space, and proposed a system called Contents Garden to expand the SKG into immersive space. We carried out the user study of SKG to evaluate its effectiveness. We also proposed and discussed three perceptual operations on Contents Garde

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Chen, Kan, and Bala Natarajan. "MIMO-Based Secret Key Generation Strategies." International Journal of Mobile Computing and Multimedia Communications 6, no. 3 (2014): 22–55. http://dx.doi.org/10.4018/ijmcmc.2014070102.

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Over the last decade, physical layer secret key generation (PHY-SKG) techniques that exploit reciprocity of wireless channels have attracted considerable interest among researchers in the field of wireless communication. Compared to traditional cryptographic methods, PHY-SKG techniques offer the following advantages: a computationally bounded adversary does not need to be assumed; PHY-SKG avoids the requirement of key management, and secret keys can be dynamically replenished. Additionally, PHY-SKG can enhance existing security schemes because it operates independently of higher layer security

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Dragone, Leonard, Laura A. Shaw, Shimon Sakaguchi, and Lisa K. Peterson. "Src-like adaptor protein (SLAP)-deficiency prevents chronic arthritis in SKG mice (49.7)." Journal of Immunology 182, no. 1_Supplement (2009): 49.7. http://dx.doi.org/10.4049/jimmunol.182.supp.49.7.

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Abstract Background: Intrinsic defects in lymphocyte signaling have been implicated in the pathogenesis of rheumatoid arthritis (RA) by a mouse model of inflammatory arthritis (SKG). SKG mice have a spontaneous mutation in ZAP-70 that leads to impaired thymocyte development, reduced positive selection and impaired negative selection of thymocytes. These defects result in autoreactive peripheral T cells that cause RA. SLAP is known to influence TCR levels and signaling in developing thymocytes. We hypothesize that SLAP-deficiency can alter TCR avidity and influence the negative selection of SKG

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Napier, Ruth J., Emily Vance, Paige Snow, Ellen J. Lee, Shimon Sakaguchi, and Holly L. Rosenzweig. "The innate immune receptor NOD2 is protective against autoimmune-induced arthritis in SKG mice." Journal of Immunology 196, no. 1_Supplement (2016): 117.5. http://dx.doi.org/10.4049/jimmunol.196.supp.117.5.

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Abstract Rheumatoid arthritis remains a major public health concern, estimated to affect 1.5 million adults in the U.S. However, the etiology and underlying immunological mechanisms of this disease remain largely speculative. SKG mice harbor a spontaneous mutation in ZAP-70 and develop arthritogenic T cells, leading to chronic, self-sustained joint destruction. Arthritis in SKG mice replicates a current theoretical paradigm that environmental factors, including microbes, activate preexisting autoreactive T cells in genetically predisposed individuals to cause disease. Currently, the mechanisms

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Hanggara, Guruh S., Laelatul Arofah, and Santy Andrianie. "Skala Kesadaran Gender Untuk Siswa Sekolah Dasar (SKG-SD)." PINUS: Jurnal Penelitian Inovasi Pembelajaran 6, no. 1 (2020): 75–89. http://dx.doi.org/10.29407/pn.v6i1.14902.

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Kesadaran gender merupakan kompetensi penting dalam perkembangan siswa SD sebagaimana terumuskan dalam SKKPD. Kasus kurangnya kesadaran gender dapat ditemukan di SD Negeri Kolomayan 2 Blitar yang belum dapat dipetakan tingkat kesadaran gendernya. Untuk dapat dijadikan sebagai landasan pemetaan maka penelitian ini bertujuan untuk menghasilkan Skala Kesadaran Gender (SKG-SD) Untuk Siswa Sekolah Dasar yang valid secara konten dan konstruk. Untuk mencapai tujuan penelitian yang diinginkan, peneliti menggunakan rancangan pengembangan instrumen. Adapun hasil yang didapatkan adalah SKG-SD dengan nila

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12

Kim, Young-Eun, Jae-Hyun Lee, Eun-Ju Lee, et al. "The Expression of the Alpha7 Nicotinic Acetylcholine Receptor and the Effect of Smoking in Curdlan-Administered SKG Mice." Biomedicines 11, no. 10 (2023): 2757. http://dx.doi.org/10.3390/biomedicines11102757.

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Nicotine, an abundant molecule in tobacco, has immunomodulatory effects on inflammatory diseases, primarily due to the activation of alpha7 nicotinic acetylcholine receptor (α7 nAChR). We aim to evaluate the expression of the α7 nAChR+ cells in joint tissue and the effect of smoking on immune cells and peripheral arthritis in curdlan-administered SKG mice, a murine model of spondyloarthropathy (SpA). The SKG mice were injected with curdlan two times at 2-week intervals and were divided into two groups; one exposed to cigarette smoke and the other not exposed. We found that the α7 nAChR+ cells

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Yoshitomi, Hiroyuki, Noriko Sakaguchi, Katsuya Kobayashi та ін. "A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice". Journal of Experimental Medicine 201, № 6 (2005): 949–60. http://dx.doi.org/10.1084/jem.20041758.

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A combination of genetic and environmental factors can cause autoimmune disease in animals. SKG mice, which are genetically prone to develop autoimmune arthritis, fail to develop the disease under a microbially clean condition, despite active thymic production of arthritogenic autoimmune T cells and their persistence in the periphery. However, in the clean environment, a single intraperitoneal injection of zymosan, a crude fungal β-glucan, or purified β-glucans such as curdlan and laminarin can trigger severe chronic arthritis in SKG mice, but only transient arthritis in normal mice. Blockade

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Chantraine, Frédéric, Céline Schreiber, José Alexandre Carvalho Pereira, Jérôme Kaps, and Frédéric Dierick. "Classification of Stiff-Knee Gait Kinematic Severity after Stroke Using Retrospective k-Means Clustering Algorithm." Journal of Clinical Medicine 11, no. 21 (2022): 6270. http://dx.doi.org/10.3390/jcm11216270.

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Nowadays, a classification system for unilateral stiff-knee gait (SKG) kinematic severity in hemiparetic adult patients after stroke does not exist. However, such classification would be useful to the clinicians. We proposed the use of the k-means method in order to define unilateral SKG severity clusters in hemiparetic adults after stroke. A retrospective k-means cluster analysis was applied to five selected knee kinematic parameters collected during gait in 96 hemiparetic adults and 19 healthy adults from our clinical gait analysis database. A total of five discrete knee kinematic clusters w

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Sinaga, Eka Margaret, Yosy Cinthya Eriwaty Silalahi, and Artha Yuliana Sianipar. "ANALISIS MINERAL KALSIUM (Ca) DAN ZAT BESI (Fe) DENGAN VARIASI WAKTU PERENDAMAN PADA PEMBUATAN SUSU KEDELAI SECARA SPEKTROFOTOMETRI SERAPAN ATOM." JURNAL FARMANESIA 7, no. 1 (2020): 60–64. http://dx.doi.org/10.51544/jf.v7i1.2768.

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Minerals, calcium, and iron are needed for humans to stay healthy and active and have various roles in the human body. The purpose of this study was to determine the levels of calcium and iron in SK1, SK2, SK3, and SK4 milk. To compare calcium and iron levels in SK1, SK2, SK3, and SK4 milk. The results of the determination of calcium and iron levels by atomic absorption spectrophotometry showed that there was a difference in the content of calcium and iron in SK3 soy milk (12.178 ± 46, 399 mg/100 ml), SK1 milk (5, 3008 ± 8, 798 mg/100). ml), SK2 milk (9, 8821 ± 55, 676 mg/100 ml), SK4 milk (4,

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Khotimah, Fridaniyanti Khusnul, Agung Sosiawan, Lintang Maudina Santosa, et al. "Dental Health Physical Exercise (SKG) for Elderly." Indonesian Journal of Dental Medicine 2, no. 1 (2020): 7. http://dx.doi.org/10.20473/ijdm.v2i1.2019.7-9.

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Background: Late adulthood is an aging process characterized by a decrease in some bodily functions. Physical changesassociated with late adulthood are musculoskeletal disorders, changes in the cardiovascular system, changes in the immunesystem, and changes in physical activity. Physical exercise is one of the ways to improve elderly’ physical activities. Anepidemiological study on elderly under Jagir Public Health Center coverage area reported that periodontitis and dentalcaries could lower physical performance in the elderly, lowering physical activity. Purpose: In consideration of theproble

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Jeong, Hyemin, Eun-Kyung Bae, Hunnyun Kim, et al. "Spondyloarthritis features in zymosan-induced SKG mice." Joint Bone Spine 85, no. 5 (2018): 583–91. http://dx.doi.org/10.1016/j.jbspin.2017.11.008.

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Dede, Emilya Grasiana, Komang Ayu Nocianitri, and Luh Putu Trisna Darmayanti. "Pengaruh Waktu Penambahan Lactobacillus rhamnosus SKG 34 terhadap Karakteristik Tape Ketan Probiotik Selama Penyimpanan." Jurnal Ilmiah Teknologi Pertanian Agrotechno 3, no. 1 (2018): 269. http://dx.doi.org/10.24843/jitpa.2018.v03.i01.p02.

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Tape is one of Indonesia's traditional fermented food that has a sweet and slightly sour taste. The basic ingredients of tape are materials that contain carbohydrates such as cassava and sticky rice. Lactobacillus rhamnosus SKG 34 is one type of lactic acid bacteria isolated from Sumbawa wild horse milk. This study aims to determine the best time addition of Lactobacillus rhamnosus SKG 34 and to determine the effect of the addition of Lactobacillus rhamnosus SKG 34 on the characteristic of probiotics Tape Ketan during storage. The study was conducted in two parts, namely first parts which aime

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Bakhitah Zulfa and Parikesit Penangsang. "Analisis Kelayakan Usaha UMKM Batik di Surabaya Kriya Galery (SKG) Siola Tunjungan." Jurnal Publikasi Ekonomi dan Akuntansi 4, no. 1 (2024): 201–14. http://dx.doi.org/10.51903/jupea.v4i1.2760.

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The strategically placed Surabaya Kriya Gallery (SKG) Siola Tunjungan in the city center is one batik MSME that is gaining attention. Through the use of original designs, coloring methods, and marketing strategies, SKG Siola Tunjungan has worked to develop batik with a dash of originality and creativity. Nonetheless, a thorough feasibility study must be carried out to guarantee the company's survival and expansion.  The purpose of this study is to evaluate the SKG Siola Tunjungan Batik UMKM company's viability in Surabaya. Qualitative descriptive research is part of this study design. In

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Li, Sheng. "Stiff Knee Gait Disorders as Neuromechanical Consequences of Spastic Hemiplegia in Chronic Stroke." Toxins 15, no. 3 (2023): 204. http://dx.doi.org/10.3390/toxins15030204.

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Stiff knee gait (SKG) is defined as decreased knee flexion during the swing phase. It is one of the most common gait disorders following stroke. Knee extensor spasticity is commonly accepted as the primary cause. Clinical management has focused on the reduction in knee extensor spasticity. Recent advances in understanding of post-stroke hemiplegic gait suggest that SKG can present as mechanical consequences between muscle spasticity, weakness, and their interactions with ground reactions during walking. Various underlying mechanisms are presented through sample cases in this article. They incl

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Dr., Rajashri Ramesh Chavan, and Pranali Balasaheb Gawade Miss. "Effectiveness of Sales Related Marketing Polices in SKG Sangha, Khed, Satara." International Journal of Advance and Applied Research S6, no. 16 (2025): 456–63. https://doi.org/10.5281/zenodo.15516042.

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<em>Aiming of this article to understand existing sales related marketing polices of the organization (SKG Sangha) and critically analyze existing sales related marketing polices by using a close ended structured schedule, discussion and observation. SKG Sangha dedicated to promoting sustainable development, particularly in rural areas, through the implementation of biogas plants and other renewable energy solution, there were Seventy-two farmers and three sales executives are considered for collecting feedback. The result shows that SKG Sangha product policies mainly focused on availability o

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Inoue, Kazuki, Erina Inoue, and Yuuki Imai. "Female sex hormones ameliorate arthritis in SKG mice." Biochemical and Biophysical Research Communications 434, no. 4 (2013): 740–45. http://dx.doi.org/10.1016/j.bbrc.2013.03.111.

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Nguyen, Quang-Linh, Sophie Dupuis, Marie-Lise Flottes, and Bruno Rouzeyre. "SKG-Lock+: A Provably Secure Logic Locking SchemeCreating Significant Output Corruption." Electronics 11, no. 23 (2022): 3906. http://dx.doi.org/10.3390/electronics11233906.

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The current trend to globalize the supply chain in the Integrated Circuits (ICs) industry has raised several security concerns including, among others, IC overproduction. Over the past years, logic locking has grown into a prominent countermeasure to tackle this threat in particular. Logic locking consists of “locking” an IC with an added primary input, the so-called key, which, unless fed with the correct secret value, renders the ICs unusable. One of the first criteria ensuring the quality of a logic locking technique was the output corruption, i.e., the corruption at the outputs of a locked

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Hashimoto, Motomu, Keiji Hirota, Hiroyuki Yoshitomi, et al. "Complement drives Th17 cell differentiation and triggers autoimmune arthritis." Journal of Experimental Medicine 207, no. 6 (2010): 1135–43. http://dx.doi.org/10.1084/jem.20092301.

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Activation of serum complement triggers Th17 cell–dependent spontaneous autoimmune disease in an animal model. In genetically autoimmune-prone SKG mice, administration of mannan or β-glucan, both of which activate serum complement, evoked Th17 cell–mediated chronic autoimmune arthritis. C5a, a chief component of complement activation produced via all three complement pathways (i.e., lectin, classical, and alternative), stimulated tissue-resident macrophages, but not dendritic cells, to produce inflammatory cytokines including IL-6, in synergy with Toll-like receptor signaling or, notably, gran

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Ashouri, Judith F., Lih-Yun Hsu, Steven Yu, et al. "Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis." Proceedings of the National Academy of Sciences 116, no. 37 (2019): 18517–27. http://dx.doi.org/10.1073/pnas.1904271116.

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How pathogenic cluster of differentiation 4 (CD4) T cells in rheumatoid arthritis (RA) develop remains poorly understood. We used Nur77—a marker of T cell antigen receptor (TCR) signaling—to identify antigen-activated CD4 T cells in the SKG mouse model of autoimmune arthritis and in patients with RA. Using a fluorescent reporter of Nur77 expression in SKG mice, we found that higher levels of Nur77-eGFP in SKG CD4 T cells marked their autoreactivity, arthritogenic potential, and ability to more readily differentiate into interleukin-17 (IL-17)–producing cells. The T cells with increased autorea

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Pakoksung, Kwanchai. "Impact of Spatial Rainfall Scenarios on River Basin Runoff Simulation a Nan River Basin Study Using the Rainfall-Runoff-Inundation Model." Eng 5, no. 1 (2023): 51–69. http://dx.doi.org/10.3390/eng5010004.

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This study aims to investigate the impact of spatial rainfall distribution scenarios from ground observation stations on runoff simulation using hydrological modeling specific to the Rainfall-Runoff-Inundation (RRI) model. The RRI model was applied with six different spatial distribution scenarios of input rainfall, including Inverse Distance Weight (IDW), Thiessen polygon (TSP), Surface Polynomial (SPL), Simple kriging (SKG), and Ordinary kriging (OKG), to simulate the runoff of a 13,000 km2 watershed, namely the Nan River Basin in Thailand. This study utilized data from the 2014 storm event,

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Setiadarma, Wulandari, Dewa Gede Mayun Permana, and Komang Ayu Nocianitri. "Optimasi Waktu Inkubasi Lactobacillus rhamnosus SKG 34 Dalam Produksi Enzim Penggumpal Susu." Jurnal Ilmu dan Teknologi Pangan (ITEPA) 9, no. 2 (2020): 108. http://dx.doi.org/10.24843/itepa.2020.v09.i02.p01.

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      This study aims to determine the effect of incubation time on milk clotting enzyme (MCE) activity produced by L. rhamnosus SKG 34 and determine the optimum incubation time to produce the highest its activity. This study used a randomized block design (RBD) with incubation time as a treatment consisting of 8 levels, that were 6 hours, 12 hours, 18 hours, 24 hours, 30 hours, 36 hours, 42 hours, and 48 hours. Data were analyzed with Variance Analysis (ANOVA) than followed by Duncan Multiple Range Test (DMRT). The analyzed were repeated 3 times resulting i

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Yuliana, Mike, Wirawan, and Suwadi. "A Simple Secret Key Generation by Using a Combination of Pre-Processing Method with a Multilevel Quantization." Entropy 21, no. 2 (2019): 192. http://dx.doi.org/10.3390/e21020192.

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Limitations of the computational and energy capabilities of IoT devices provide new challenges in securing communication between devices. Physical layer security (PHYSEC) is one of the solutions that can be used to solve the communication security challenges. In this paper, we conducted an investigation on PHYSEC which utilizes channel reciprocity in generating a secret key, commonly known as secret key generation (SKG) schemes. Our research focused on the efforts to get a simple SKG scheme by eliminating the information reconciliation stage so as to reduce the high computational and communica

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Rehaume, Linda M., Nicholas Matigian, Ahmed M. Mehdi, et al. "IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiota." Annals of the Rheumatic Diseases 78, no. 4 (2019): 494–503. http://dx.doi.org/10.1136/annrheumdis-2018-214381.

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ObjectivesCertain gut bacterial families, including Bacteroidaceae, Porphyromonadaceae and Prevotellaceae, are increased in people suffering from spondyloarthropathy (SpA), a disease group associated with IL23R signalling variants. To understand the relationship between host interleukin (IL)-23 signalling and gut bacterial dysbiosis in SpA, we inhibited IL-23 in dysbiotic ZAP-70-mutant SKG mice that develop IL-23-dependent SpA-like arthritis, psoriasis-like skin inflammation and Crohn’s-like ileitis in response to microbial beta 1,3-glucan (curdlan).MethodsWe treated SKG mice weekly with anti-

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Shan, Yongxue, Jie Zhou, Jie Peng, Xin Zhou, Jiaqian Yin, and Xiaodong Wang. "Multi-level Shared Knowledge Guided Learning for Knowledge Graph Completion." Transactions of the Association for Computational Linguistics 12 (2024): 1027–42. http://dx.doi.org/10.1162/tacl_a_00686.

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Abstract In the task of Knowledge Graph Completion (KGC), the existing datasets and their inherent subtasks carry a wealth of shared knowledge that can be utilized to enhance the representation of knowledge triplets and overall performance. However, no current studies specifically address the shared knowledge within KGC. To bridge this gap, we introduce a multi-level Shared Knowledge Guided learning method (SKG) that operates at both the dataset and task levels. On the dataset level, SKG-KGC broadens the original dataset by identifying shared features within entity sets via text summarization.

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Santos, Gilmar F., Eike Jakubowitz, and Christof Hurschler. "Predicting prosthetic gait and the effects of induced stiff-knee gait." PLOS ONE 20, no. 1 (2025): e0314758. https://doi.org/10.1371/journal.pone.0314758.

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Prosthetic gait differs considerably from the unimpaired gait. Studying alterations in the gait patterns could help to understand different adaptation mechanisms adopted by these populations. This study investigated the effects of induced stiff-knee gait (SKG) on prosthetic and healthy gait patterns and the capabilities of predictive simulation. Self-selected speed gait of two participants was measured: one healthy subject and one knee disarticulation subject using a variable-damping microprocessor controlled knee prosthesis. Both performed unperturbed gait and gait with restricted knee flexio

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Asare-Konadu, Kofi N., Emily E. Vance, Rouhin Sen, Liron Caplan, Holly L. Rosenzweig, and Ruth J. Napier. "Neutrophils control autoreactive Th17 responses in spondyloarthritis." Journal of Immunology 208, no. 1_Supplement (2022): 108.16. http://dx.doi.org/10.4049/jimmunol.208.supp.108.16.

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Abstract Spondylarthritis (SpA) refers to a group of autoimmune diseases characterized by inflammation of the spine (spondylitis) and joints (arthritis) including ankylosing spondylitis and psoriatic arthritis. Genetic studies suggest that autoreactive Th17 cells drive SpA pathogenesis and in support IL-17 blockade in the clinic moderates symptoms. Although Th17 responses appear to be key in driving symptomatic disease, less is understood of the underlying innate cellular mechanisms that contribute to the initiation of pathogenic T cells. Upon analysis of SpA patient cell blood count data (1,4

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Gagey, Pierre-Marie. "La surface du SKG : mauvais marqueur de la stabilité ?" Neurophysiologie Clinique 49, no. 3 (2019): 256. http://dx.doi.org/10.1016/j.neucli.2019.01.020.

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Levina, Zh L., Yu P. Zheleznov, V. N. Molochnikova, A. I. Vinnikov, and V. V. Gorokhov. "Design and tests of cryogenic SKG-630 helium tanks." Chemical and Petroleum Engineering 26, no. 7 (1990): 357–59. http://dx.doi.org/10.1007/bf01147361.

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Cameron, A., R. Giri, J. Begun, T. Wells, A. S. Bergot, and R. Thomas. "POS0431 GOBLET CELL SPECIFIC ANTI-APOPTOTIC ROLE OF INTERLEUKIN-24 IN SPONDYLOARTHRITIS-ASSOCIATED ILEITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 471.2–472. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1346.

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BackgroundSpondyloarthritis (SpA) is characterised by chronic debilitating axial and peripheral joint inflammation, often concomitant with inflammatory bowel disease (IBD)-like gut phenotypes. However, the contribution of extra-articular gut pathologies to SpA is not well understood. The ZAP-70W163CBALB/c (SKG) mouse model of SpA develop chronic arthritis, spondylitis and IBD-like ileitis commencing from 1 week after intraperitoneal curdlan injection with characteristic interleukin-23-dependent gut dysbiosis, endoplasmic reticulum (ER) stress and goblet cell depletion. The cytokine interleukin

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Lau, Max C., Patricia Keith, Mary-Ellen Costello, et al. "Genetic association of ankylosing spondylitis with TBX21 influences T-bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis." Annals of the Rheumatic Diseases 76, no. 1 (2016): 261–69. http://dx.doi.org/10.1136/annrheumdis-2015-208677.

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ObjectivesAnkylosing spondylitis (AS) is a highly heritable immune-mediated arthropathy. Inflammation in AS is poorly understood. TBX21 encodes T-bet, a transcription factor, lying within a locus with genome-wide significant association with AS. T-bet is implicated in innate and adaptive immunity. However, the role of T-bet in AS pathogenesis is unclear.MethodsWe assessed the importance of T-bet in disease development and progression in peripheral blood mononuclear cells from 172 AS cases and 83 healthy controls carrying either risk or protective alleles of the peak AS-associated TBX21 single

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Koney, Kylie, Sydney J. Lashley, Ellen J. Lee, et al. "T cell intrinsic Nod2 controls Th17 immunity to Candida albicans infection." Journal of Immunology 208, no. 1_Supplement (2022): 58.08. http://dx.doi.org/10.4049/jimmunol.208.supp.58.08.

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Abstract We recently discovered a role for Nod2 within T cells in controlling Th17-immunity, such that deletion of Nod2 exacerbated experimental autoimmune arthritis and uveitis. Protection against opportunistic Candida albicans infection relies on intact Th17-responses. Thus, we considered whether the T cell intrinsic Nod2 might control antifungal Th17 responses at the cost of increasing host susceptibility to autoimmunity. Nod2−/− mice infected with 105 (LD50) Candida albicans had increased survival and reduced fungal burden in the kidney within 24–72 h post-infection, suggesting a critical

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Hung, Shu-Chen, Narendiran Rajasekaran, Shoujun Zhu, Zhuoran Ma, Eliver Ghosn, and Elizabeth D. Mellins. "Single-walled carbon nanotubes target neutrophils and Ly-6Chi monocytes and localize to joints in murine models of arthritis." Journal of Immunology 200, no. 1_Supplement (2018): 175.23. http://dx.doi.org/10.4049/jimmunol.200.supp.175.23.

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Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease that often leads to joint damage. The etiology of RA remains unclear, but new insights and therapeutic strategies have been facilitated by murine models. In the K/BxN serum transfer (STA) model, arthritis is triggered by autoantibodies against glucose-6-phosphate isomerase. The SKG model has a ZAP70 point mutation that reduces TCR signaling. After zymosan exposure, SKG mice develop arthritis, mediated by autoreactive Th17 cells. Joint inflammation in these models shares many features with RA, including leukocyte invasion, synov

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Adil, Muhammad, Shurjeel Wyne, Junaid Nawaz Syed, and Bilal Muhammad. "Average Contiguous Duration (ACD)-Based Quantization for Secret Key Generation in Generalized Gamma Fading Channels." IEEE Access 9 (July 28, 2021): 110435–50. https://doi.org/10.1109/access.2021.3100925.

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The wireless channel-based Secret Key Generation (SKG) algorithms aim at securing the wireless link against unauthorized eavesdropping by exploiting the channel’s randomness for generating matching secret keys at the legitimate nodes for message encryption/decryption. To counter differences in hardware and noise conditions at the legitimate nodes, which can lead to key mismatch, the SKG algorithms typically include the intermediate steps of sampling, quantization, information reconciliation, and privacy amplification. These steps collectively aim to improve the performance trade-offs bet

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Hsu, Lih-Yun, Ying-Xim Tan, and Arthur Weiss. "A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity (49.6)." Journal of Immunology 182, no. 1_Supplement (2009): 49.6. http://dx.doi.org/10.4049/jimmunol.182.supp.49.6.

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Abstract ZAP-70, a Syk family protein tyrosine kinase, is critical for efficient signaling downstream of the TCR. Our lab and others have previously shown that tyrosine 315 and 319 in the interdomain B positively regulate ZAP-70 function by recruiting Vav1 and Lck, respectively. Surprisingly, in addition to their scaffolding function, we recently discovered that Y315 and Y319 play an important role in the autoinhibition ZAP-70 kinase activity. To address the relative importance of the scaffolding function of these residues versus their autoinhibition function, we generated a knock-in ZAP-70 mu

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Kleinschmidt, Andreas, Antonella Palla, Christoph Schankin, et al. "9. Dreiländertagung Kopfschmerz." Nervenheilkunde 43, no. 04 (2024): 209–18. http://dx.doi.org/10.1055/a-2267-0429.

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Rothe, Kathrin, Dagmar Quandt, Gabriele Köhler, et al. "PIR-B expressing CD8+ T cells exhibit features of Tc1 and Tc17 in SKG mice." Rheumatology 58, no. 12 (2019): 2325–29. http://dx.doi.org/10.1093/rheumatology/kez256.

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Abstract Objective In autoimmune arthritis, TCR signalling is attenuated by peripheral tolerance mechanisms. We have described previously a population of inhibitory receptor LIR-1 expressing autoreactive CD8+ T cells in rheumatoid arthritis. Here, we investigated the role of CD8+ T cells in murine autoimmune arthritis by analysing their expression of the mouse orthologue of LIR-1, PIR-B. Methods Frequencies of PIR-B+CD8+ T cells were determined in the SKG arthritis model. The phenotype of those cells was determined ex vivo by FACS and functionality was investigated by means of cytokine product

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Amna K. Faraj. "Cytotoxic Effect of flavonoids extracted from Conocarpus erectus leaves on SKG cell." Journal of AL-Farabi for Medical Sciences 1, no. 1 (2023): 9. http://dx.doi.org/10.59746/jfms.v1i1.20.

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The present study was conducted to investigate the cytotoxic activity flavonoids extracted from Conocarpus erectus L. leaves using ethyl acetate and chloroform, the results of the extracted flavonoids were detected by HPLC. The evaluation of its cytotoxic effect on cancerous SKG cell line Human Esophageal Cancer and non-cancerous REF (rat embryonic fibroblast) using MTT assay. HPLC analysis of both extracts showed 6 out of 10 flavonoids matched the standard peaks which were (Catechin, Rutin, Myrecetin, Quercetin, Apigenine and Kaempferol). The cytotoxicity of the ethyl acetate extract was grea

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Ivanenko, Elizaveta, and Tatiana Menshutina. "Productive and adaptive potentials of Renet Simirenko variety on rootstocks with different growth rates in arid conditions." BIO Web of Conferences 34 (2021): 01008. http://dx.doi.org/10.1051/bioconf/20213401008.

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This article presents the results of the economic and biological assessment of the Renet Simirenko variety grown on rootstocks of different growth rates under conditions of insufficient moisture and high thermal stress in the arid zone of the Northern Caspian region. The purpose of the research is to study and identify scion-rootstock combinations of the Renet Simirenko variety, which most fully realize the potential of productivity, early maturity, and resistance to unfavorable environmental factors. Studied variety grew more intensively on dwarf rootstocks (SK4, SK7), semi-dwarf (SK2, SK5),

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Mizutani, Satoshi, Junko Nishio, Kanoh Kondo, et al. "Treatment with an Anti-CX3CL1 Antibody Suppresses M1 Macrophage Infiltration in Interstitial Lung Disease in SKG Mice." Pharmaceuticals 14, no. 5 (2021): 474. http://dx.doi.org/10.3390/ph14050474.

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CX3C Motif Chemokine Ligand 1 (CX3CL1; fractalkine) has been implicated in the pathogenesis of rheumatoid arthritis (RA) and its inhibition was found to attenuate arthritis in mice as well as in a clinical trial. Therefore, we investigated the effects of an anti-CX3CL1 monoclonal antibody (mAb) on immune-mediated interstitial lung disease (ILD) in SKG mice, which exhibit similar pathological and clinical features to human RA-ILD. CX3CL1 and CX3C chemokine receptor 1 (CX3CR1), the receptor for CX3CL1, were both expressed in the fibroblastic foci of lung tissue and the number of bronchoalveolar

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Hsu, Lih-Yun, Ying Xim Tan, Zheng Xiao, Marie Malissen, and Arthur Weiss. "A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity." Journal of Experimental Medicine 206, no. 11 (2009): 2527–41. http://dx.doi.org/10.1084/jem.20082902.

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ZAP-70 is critical for T cell receptor (TCR) signaling. Tyrosine to phenylalanine mutations of Y315 and Y319 in ZAP-70 suggest these residues function to recruit downstream effector molecules, but mutagenesis and crystallization studies reveal that these residues also play an important role in autoinhibition ZAP-70. To address the importance of the scaffolding function, we generated a zap70 mutant mouse (YYAA mouse) with Y315 and Y319 both mutated to alanines. These YYAA mice reveal that the scaffolding function is important for normal development and function. Moreover, the YYAA mice have man

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Kashiuchi, Shoko, Rikako Miyazawa, Honoka Nagata, et al. "Effects of administration of glucosamine and chicken cartilage hydrolysate on rheumatoid arthritis in SKG mice." Food & Function 10, no. 8 (2019): 5008–17. http://dx.doi.org/10.1039/c9fo00981g.

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Owada, Takayoshi, Kazuhiro Kurasawa, Hitoshi Endou, Tomoe Fujita, Naohiko Anzai, and Keitaro Hayashi. "LAT1-specific inhibitor ameliorates severe autoimmune arthritis in SKG mouse." International Immunopharmacology 109 (August 2022): 108817. http://dx.doi.org/10.1016/j.intimp.2022.108817.

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Tabuchi, Y., M. Hashimoto, S. Akizuki, et al. "SAT0349 CTLA4-IG DECREASES TH17 CELL LEVELS BUT MAINTAINS ILC3S WITH AN INCREASE IN THE ILC3/ILC1 RATIO IN THE GUT OF SKG MICE AS A MODEL OF SPONDYLOARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1120.1–1121. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1117.

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Background:SKG mice have been known for their autoreactive Th17 cells resulting from the insufficient thymic negative selection due to a Zap70 mutation1,2). Under specific pathogen-free conditions, they acquire features of spondyloarthritis (SpA) by intraperitoneal injection of curdlan, a (1,3)-β-glucan3). Several reports have shown that Th17 cells also increase in human SpA4). However, CTLA4-Ig, which ameliorates rheumatoid arthritis by suppressing pathogenic cells such as effector T cells, was unable to show adequate efficacy as much as expected in SpA patients5). Around the same time, innat

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Alida, Roni, and Rangga Abi Pratama. "P PENCEGAHAN KOROSI PADA FLOWLINE 28” SKG 10 PMB - BENUANG MENGGUNAKAN METODE IMPRESSED CURRENT CATHODIC PROTECTION (ICCP) PT PERTAMINA HULU ROKAN REGION 1 ZONA 4 FIELD PRABUMULIH." Jurnal Teknik Patra Akademika 13, no. 01 (2022): 57–65. http://dx.doi.org/10.52506/jtpa.v13i01.145.

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Salah satu penyebab kerusakan pada sistem jaringan dan fasilitas pipa distribusi yaitu korosi. Mencegah terjadinya korosi pada flowline, PT Pertamina Hulu Rokan Region 1 Zona 4 Field Prabumulih yang berada di SKG 10 Prabumulih Barat menggunakan sistem proteksi katodik. Proteksi Katodik (Cathodic Protection) adalah teknik yang digunakan untuk mengendalikan korosi pada permukaan logam dengan menjadikan permukaan logam tersebut sebagai katoda dari sel elektrokimia. Pada PT Pertamina Hulu Rokan Region 1 Zona 4 Field Prabumulih digunakan sistem proteksi katodik arus tanding atau yang dikenal dengan

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