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Journal articles on the topic 'Skin and Mucosal Allergy'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Wang, Yui-Hsi. "Developing food allergy: a potential immunologic pathway linking skin barrier to gut." F1000Research 5 (November 10, 2016): 2660. http://dx.doi.org/10.12688/f1000research.9497.1.

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Immunoglobulin E (IgE)-mediated food allergy is an adverse reaction to foods and is driven by uncontrolled type-2 immune responses. Current knowledge cannot explain why only some individuals among those with food allergy are prone to develop life-threatening anaphylaxis. It is increasingly evident that the immunologic mechanisms involved in developing IgE-mediated food allergy are far more complex than allergic sensitization. Clinical observations suggest that patients who develop severe allergic reactions to food are often sensitized through the skin in early infancy. Environmental insults tr

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Frederick, Daniel, James McLachlan, and Lucy Freytag. "Parenteral immunization with double-mutant heat labile toxin engages CD103+ dermal dendritic cells and redirects T cell immunity to the gut mucosa. (MUC4P.833)." Journal of Immunology 192, no. 1_Supplement (2014): 133.9. http://dx.doi.org/10.4049/jimmunol.192.supp.133.9.

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Abstract The vast majority of infectious agents enter hosts through mucosal compartments. Despite this, most current vaccines are administered via parenteral injection, which induce vigorous systemic but only limited mucosal immune responses. Studies have suggested that certain adjuvants can induce mucosal antibody responses regardless of route; however, there is minimal evidence that these injections direct antigen-specific effector T cells to the mucosa, where they are likely needed for protection against mucosal pathogens. We sought to explore the potential of the mucosal adjuvant dmLT (dou

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Nakano, Nobuhiro, and Jiro Kitaura. "Mucosal Mast Cells as Key Effector Cells in Food Allergies." Cells 11, no. 3 (2022): 329. http://dx.doi.org/10.3390/cells11030329.

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Mucosal mast cells (MMCs) localized in the intestinal mucosa play a key role in the development of IgE-mediated food allergies. Recent advances have revealed that MMCs are a distinctly different population from connective tissue mast cells localized in skin and other connective tissues. MMCs are inducible and transient cells that arise from bone marrow-derived mast cell progenitors, and their numbers increase rapidly during mucosal allergic inflammation. However, the mechanism of the dramatic expansion of MMCs and their cell functions are not well understood. Here, we review recent findings on

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Brandt, Eric B., Paige E. Bolcas, Dana Shik, Brandy P. Ruff, and Gurjit K. Khurana Hershey. "TSLP rather than IL-33 signaling drives intestinal mucosal mast accumulation and allergen-induced diarrhea in mice following epicutaneous sensitization to food allergen." Journal of Immunology 206, no. 1_Supplement (2021): 94.01. http://dx.doi.org/10.4049/jimmunol.206.supp.94.01.

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Abstract Background: A major route of sensitization to food allergen is through an impaired skin barrier. IL33 and TSLP have both been implicated in epicutaneous sensitization and development of food allergy. Method: We assessed the respective contributions of TSLP and IL33 to the development of food allergy in TSLP and IL33 receptor deficient mice following epicutaneous food allergen sensitization, where mice were exposed to thrice weekly skin patches of either saline, OVA or a combination of OVA and Aspergillus fumigatus extract (ASP). Results: ASP+OVA-patched but not OVA-patched mice develo

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Hurst, David S., and Kjeld Fredens. "Eosinophil cationic protein in mucosal biopsies from patients with allergy and otitis media with effusion." Otolaryngology–Head and Neck Surgery 117, no. 1 (1997): 42–48. http://dx.doi.org/10.1016/s0194-59989770204-3.

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Nine patients with persistent middle ear effusion and allergy confirmed by skin testing were evaluated for eosinophils by histochemical staining of middle ear mucosal biopsy specimens for eosinophil cationic protein. The study was designed to determine whether eosinophils were present in the middle ear mucosa of these patients and whether the elevated levels of eosinophil cationic protein reported in effusion from patients with chronic otitis media with effusion and allergy might originate within the mucosa itself. Seven of nine patients with otitis media with effusion had eosinophil cationic

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Abby Wong, Carlson James, and Manika Sharma. "Skin Reaction to an Asthmatic Patient on Hydrocortisone." International Healthcare Research Journal 6, no. 12 (2023): RV4—RV6. http://dx.doi.org/10.26440/ihrj/0611.02595.

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Steroids constitute the basic of treatment of asthma by interrupting the development of inflammation. Although being prescribed to subjects for allergies, they can also be the culprit behind allergic reactions. We report a case of a 38-year-old woman, who was prescribed hydrocortisone for severe acute asthma, and presented with an allergy to hydrocortisone in the form of generalized pruritus, cutaneous mucosal lesions in the form of purpura and ecchymoses on the abdomen and limbs. The substitution of hydrocortisone led to recovery.

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Dr., Arun Pandiyan. S* Neena Baby Neetha Sabu Lubna Sulthana Navya Sunil. "ROSUVASTATIN INDUCED SKIN AND MUCOSAL ALLERGY (ERYTHEMATOUS PAPAULAR DERMATITIS)." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 421–24. https://doi.org/10.5281/zenodo.1036397.

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Rosuvastatin is a Lipid lowering agents which belong to class HMG Co-A Reductase inhibitors. In clinical trials, adverse drug reactions of rosuvastatin >10% were Neuromuscular & skeletal, in that Myalgia (2% to 13%). Only 1%, post marketing, and /or case reports reported hypersensitivity reaction (including angioedema, pruritus, skin rash, urticaria). Here we present a case with skin and mucosal allergy (erythematous papaular dermatitis) caused by Rosuvastatin.

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Sultana, Salma, Shyam Gade, and Kaiser Jamil. "Mapping the Major Aeroallergens Causing Allergic Rhinitis in Telangana State in India." International Journal of Medical Science and Health Research 09, no. 01 (2025): 110–21. https://doi.org/10.51505/ijmshr.2025.9109.

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Allergic Rhinitis (AR) is one of the commonest allergic disorders. It is defined as the inflammatory disorder of the mucosal lining of the nose caused by exposure to allergens such as pollen, dust, feathers etc. AR leads to impaired quality of life and hinders social and professional life. In this study, we analysed the pattern of allergen sensitivity among the patients presenting with allergic rhinitis across Telangana. India is a vast country with a wide variety of geographical landscapes; hence the pattern of allergen sensitivity may differ from place to place and with changing climatic con

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Briard, Mélanie, Marine Guinot, Marta Grauso, et al. "Route of Sensitization to Peanut Influences Immune Cell Recruitment at Various Mucosal Sites in Mouse: An Integrative Analysis." Nutrients 14, no. 4 (2022): 790. http://dx.doi.org/10.3390/nu14040790.

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Symptom occurrence at the first ingestion suggests that food allergy may result from earlier sensitization via non-oral routes. We aimed to characterize the cellular populations recruited at various mucosal and immune sites after experimental sensitization though different routes. BALB/cJ mice were exposed to a major allergenic food (peanut) mixed with cholera toxin via the intra-gastric (i.g.), respiratory, cutaneous, or intra-peritoneal (i.p.) route. We assessed sensitization and elicitation of the allergic reaction and frequencies of T cells, innate lymphoid cells (ILC), and inflammatory an

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Bonnegarde-Bernard, Astrid, Junbae Jee, Michael Fial, Famke Aeffner та Prosper Boyaka. "Intestinal epithelial cells IKKβ regulate allergic responses in the skin (P6053)". Journal of Immunology 190, № 1_Supplement (2013): 120.27. http://dx.doi.org/10.4049/jimmunol.190.supp.120.27.

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Abstract The sites where immune responses are initiated are believed to play a key role at shaping subsequent responses at distant mucosal sites. We have previously shown that IKKβ in intestinal epithelial cells (IECs) shapes the immune responses to ingested antigens and influences airway responses to subsequent antigen exposure via regulation of IgA and Th17. People with food allergy often suffer from allergic airway and/or skin diseases like asthma or atopic dermatitis but it is unknown whether T cells sensitized in the gut promote inflammation at different mucosal surfaces through the same

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Jin, Yining, Haoran Gao, Rick Jorgensen, et al. "Mechanisms of Wheat Allergenicity in Mice: Comparison of Adjuvant-Free vs. Alum-Adjuvant Models." International Journal of Molecular Sciences 21, no. 9 (2020): 3205. http://dx.doi.org/10.3390/ijms21093205.

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Wheat protein is considered a major type of food allergen in many countries including the USA. The mechanisms of allergenicity of wheat proteins are not well understood at present. Both adjuvant-based and adjuvant-free mouse models are reported for this food allergy. However, it is unclear whether the mechanisms underlying wheat allergenicity in these two types of models are similar or different. Therefore, we compared the molecular mechanisms in a novel adjuvant-free (AF) model vs. a conventional alum-adjuvant (AA) model of wheat allergy using salt-soluble wheat protein (SSWP). In the AF mode

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Yoshizawa, Takamasa, Kenichi Kumagai, Ryota Matsubara, et al. "Characterization of Metal-Specific T-Cells in Inflamed Oral Mucosa in a Novel Murine Model of Chromium-Induced Allergic Contact Dermatitis." International Journal of Molecular Sciences 24, no. 3 (2023): 2807. http://dx.doi.org/10.3390/ijms24032807.

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The element chromium (Cr) is a component of several types of alloys found in the environment, or utilized in dentistry, that may cause intraoral metal contact allergy. However, the pathological mechanism of intraoral Cr allergy remains unclear because there is no established animal model of Cr allergy in the oral mucosa. In this study, we established a novel murine model of Cr-induced intraoral metal contact allergy and elucidated the immune response in terms of cytokine profiles and T-cell receptor repertoire. Two sensitizations with Cr plus lipopolysaccharide solution into the postauricular

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Holmstrup, P. "Oral Mucosa and Skin Reactions Related to Amalgam." Advances in Dental Research 6, no. 1 (1992): 120–24. http://dx.doi.org/10.1177/08959374920060010401.

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Documented cases of oral mucosa and skin affections related to amalgam restorations are rare, although the exact incidence is unknown. Lesions of the oral mucosa may be due to specific immunologic or non-specific toxic reactions toward products generated from restorations. The immunologic reaction most probably involved in mucosal affections related to amalgam is the delayed or cell-mediated (type IV) reaction. Such reactions are seen in contact allergy, and the term "contact lesions of the oral mucosa" has been used. There is a much lower tendency of sensitization through mucous membranes tha

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Muin, Rima Yuliati, Darwati Muhadi, and Mansyur Arif. "EOSINOFIL PASCA MENGEROK MUKOSA HIDUNG DAN PEMERIKSAAN DARAH RUTIN DI RINITIS ALERGI." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 16, no. 1 (2018): 36. http://dx.doi.org/10.24293/ijcpml.v16i1.995.

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Diagnostic of rhinitis allergy was based on anamnesis, physical examinations. Examine including anterior rhinoscopy, nasal endoscope, skin test and laboratory assay of nasal cytology, eosinofil count in the blood. Eosinofil mucosal nasal brushing assay andeosinofil routine hematology can be used as other examination to diagnose rhinitis allergy and to evaluate therapy response. The aimof the study was to know the correlation between eosinofil level on mucosal nasal brushing and routine hematology in suspect allergyrhinitis. The study used cross sectional methods, and was done among 37 suspecte

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Rivera-Mariani, Felix Emanuel, Hayat Srour, Ruslan Fomenko, Shandra Bellinger, Ariel Stateman, and Joshua Baguley. "Profile of Dendritic Cells Surface Biomarkers in Nasal and Oral Mucosa of Human Subjects Reactive to Grass Pollen and House Dust Mites." Journal of Immunology 202, no. 1_Supplement (2019): 55.18. http://dx.doi.org/10.4049/jimmunol.202.supp.55.18.

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Abstract Dendritic cells (DCs) play key roles in human allergic pathophysiology at different anatomic sites, such as the respiratory tract. To identify relationships between DCs subpopulations in the upper respiratory tract and atopic status, a public-available dataset (http://doi.org/10.5281/zenodo.50228) on nasal and oral DCs cell-surface biomarkers expression following allergen challenge (through skin prick test) was re-analyzed, with regression and principal component analysis (PCA), to identify profiles of DC cell-surface biomarkers based on the allergen reactivity. The dataset included i

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Mustafa, Mayson B., Stephen R. Porter, Bruce R. Smoller, and Cassian Sitaru. "Oral mucosal manifestations of autoimmune skin diseases." Autoimmunity Reviews 14, no. 10 (2015): 930–51. http://dx.doi.org/10.1016/j.autrev.2015.06.005.

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Hovav, Avi-Hai. "Mucosal and Skin Langerhans Cells – Nurture Calls." Trends in Immunology 39, no. 10 (2018): 788–800. http://dx.doi.org/10.1016/j.it.2018.08.007.

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Makarova, S. G., L. S. Namazova-Baranova, N. N. Murashkin, et al. "Food Allergy in Children with Inherited Epidermolysis Bullosa. The Results of the Observational Study." Annals of the Russian academy of medical sciences 73, no. 1 (2018): 49–58. http://dx.doi.org/10.15690/vramn847.

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Background: Inherited epidermolysis bullosa (EB) refers to a group of rare inherited disorders characterized by severe damage of skin and in most patients — the gastrointestinal mucosa, what leads to a violation of skin and mucosal barrier properties in relation to allergens. However, the issues of food sensitization and food allergy in this category of patients have not been studied, and the study of this problem is important.Aim: To evaluate the clinical manifestations of food allergy (FA) and IgE-response to food proteins in children with EB.Methods: 82 patients with EB aged from 2 months t

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Gómez-Duarte, Oscar G., and Pearay L. Ogra. "Development of Mucosal Immunity: Functional Interactions with Mucosal Microbiome in Health and Disease." Current Immunology Reviews 15, no. 2 (2019): 154–65. http://dx.doi.org/10.2174/1573395515666190225153529.

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The mucosal surfaces and the skin are the primary sites of interactions between the mammalian host and the external environment. These sites are exposed continuously to the diverse components of the environment, including subcellular, unicellular and multicellular organisms, dietary agents and food products; and numerous other soluble or cellular air or water borne products. The development of innate and adaptive immunity in the mucosal surfaces and the skin are the principal mechanism of mammalian defense evolved to date, in order to maintain effective homeostatic balance between the host and

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Iqbal, Hamid, and Dong-Kwon Rhee. "Intranasal Immunization of Pneumococcal pep27 Mutant Attenuates Allergic and Inflammatory Diseases by Upregulating Skin and Mucosal Tregs." Vaccines 12, no. 7 (2024): 737. http://dx.doi.org/10.3390/vaccines12070737.

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Conventional immunization methods such as intramuscular injections lack effective mucosal protection against pathogens that enter through the mucosal surfaces. Moreover, conventional therapy often leads to adverse events and compromised immunity, followed by complicated outcomes, leading to the need to switch to other options. Thus, a need to develop safe and effective treatment with long-term beneficial outcomes to reduce the risk of relapse is mandatory. Mucosal vaccines administered across mucosal surfaces, such as the respiratory or intestinal mucosa, to prompt robust localized and systemi

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DelGaudio, John M., Patricia A. Loftus, Aneeza W. Hamizan, Richard J. Harvey, and Sarah K. Wise. "Central Compartment Atopic Disease." American Journal of Rhinology & Allergy 31, no. 4 (2017): 228–34. http://dx.doi.org/10.2500/ajra.2017.31.4443.

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Background Isolated polypoid changes of the middle turbinate were recently reported as having a high association with inhalant allergy. A more advanced manifestation of this association may present as polypoid changes of the entire central sinonasal compartment (i.e., the middle and superior turbinates, and the posterosuperior nasal septum), while the lateral sinus mucosa remains relatively normal. Objective To introduce and describe this newly recognized variant of chronic rhinosinusitis (CRS), termed central compartment atopic disease (CCAD). Methods A case series of 15 patients from two ins

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Martins, Luís Miguel Lourenço. "Survey of Sensitization to Common Fungi in an Allergic Dog Population: The Need for Further Focus on Sensitization and Allergy to Fungi in Veterinary Medicine." Journal of Fungi 9, no. 11 (2023): 1075. http://dx.doi.org/10.3390/jof9111075.

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Most fungal species are commensals and non-pathogenic to plants, humans, or animals. However, several species of the Alternaria, Aspergillus, Trichophyton, and Microsporum genera are common causes of disease, even for immunocompetent individuals. Besides mucosal damage, fungi may contribute to a skin barrier impairment, favoring sensitization and allergy development. A total of 68 allergic dogs were selected from a veterinary dermatology and allergy outpatient consultation for conditions related to both Malassezia overgrowth and other fungal complications. The allergy diagnosis was made throug

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Jacquet, Alain. "Innate Immune Responses in House Dust Mite Allergy." ISRN Allergy 2013 (February 28, 2013): 1–18. http://dx.doi.org/10.1155/2013/735031.

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Sensitizations to house dust mites (HDM) trigger strong exacerbated allergen-induced inflammation of the skin and airways mucosa from atopic subjects resulting in atopic dermatitis as well as allergic rhinitis and asthma. Initially, the Th2-biased HDM allergic response was considered to be mediated only by allergen B- and T-cell epitopes to promote allergen-specific IgE production as well as IL-4, IL-5, and IL-13 to recruit inflammatory cells. But this general molecular model of HDM allergenicity must be revisited as a growing literature suggests that stimulations of innate immune activation p

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Butrym, Iga, Sylwia Płaczkowska, Lilla Pawlik-Sobecka, and Sylwia Smolińska. "Basic diagnostic tests of IgE dependent and contact allergy." Diagnostyka Laboratoryjna 53, no. 3 (2017): 169–74. http://dx.doi.org/10.5604/01.3001.0013.7978.

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Allergy is a hypersensitive immune response against non-pathogenic external factors that either enters the body or have a direct contact with the skin or mucosa. Diagnosis of allergy is a complex, multi-stage process in which the main role plays medical history analysis of the disease and its confirmation by additional tests, such as skin tests and allergen-specific IgE serum antibody assays. Skin tests can be used, with variable success, in diagnosis of all allergies. However, they have the greatest significance in diagnosing of contact and inhalation allergies. In the diagnosis of atopic, wh

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Ahmed, Afan, Faraidon Fathala, and Diyar Majeed. "Measurement of IgE hypersensitivity among people attending the tertiary allergic center in Kirkuk, Iraq." Al-Kitab Journal for Pure Sciences 3, no. 2 (2020): 259–67. http://dx.doi.org/10.32441/kjps.03.02.p24.

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Immunoglobulin E (IgE) is ordered as the least abundant, but in many regards, the most potent, of the enormous antibody classes found in the mammals. IgE mediates the reactions of type 1 hypersensitivity allergic. Generally, IgE plasma levels are very low with 100,000-fold than those of Immunoglobulin G. However, these levels could be obviously increased in specific conditions of allergy, such as bronchopulmonary aspergillosis, or in case of parasitic diseases like schistosomiasis. Additionally, plasma cells of IgE exist in mucosal areas. In particular, it exists in the respiratory tract, wher

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Katzenellenbogen, Rachel A., Joseph J. Carter, Joshua E. Stern, et al. "Skin and Mucosal Human Papillomavirus Seroprevalence in Persons with Fanconi Anemia." Clinical and Vaccine Immunology 22, no. 4 (2015): 413–20. http://dx.doi.org/10.1128/cvi.00665-14.

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ABSTRACTPersons with Fanconi anemia (FA) are at risk for human papillomavirus (HPV)-associated cancers; however, their natural HPV exposure and infection rates are unknown as is the adequacy with which they mount antibodies to HPV vaccination. This study aimed to determine, in 62 persons with FA, the seroprevalence of skin and mucosal HPV types, the seroprevalence in individuals self-reporting a history of HPV vaccination, and the factors associated with HPV seropositivity. A bead Luminex assay was used to determine seropositivity for HPV1, -2, and -4 (low-risk skin), -6 and -11 (low-risk muco

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Constantinides, Michael G., Jonathan L. Linehan, Shurjo Sen, et al. "Mucosal-associated invariant T cells respond to cutaneous microbiota." Journal of Immunology 198, no. 1_Supplement (2017): 218.15. http://dx.doi.org/10.4049/jimmunol.198.supp.218.15.

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Abstract The microbiome consists of a diverse array of commensal microorganisms that reside at barrier sites of the body and promote immune homeostasis through the release of microbial products, including derivatives of vitamin synthesis. Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize vitamin B2 (riboflavin) derivatives presented by the major histocompatibility class I-like molecule, MR1. MAIT cells are predominantly located in barrier tissues, where they represent a substantial population of non-classical T cells and provide an initial defense to pathoge

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Lu, Huai Xiu, Bin Deng, Long Quan Shao, et al. "A New Type of Colored Alumina/Glass Composite Biological Safety Assessment - Oral Mucous Membrane Irritation and Skin Sensitivity Tests." Advanced Materials Research 177 (December 2010): 462–65. http://dx.doi.org/10.4028/www.scientific.net/amr.177.462.

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Objective: to describe and demonstrate an oral mucosa irritation and a skin sensitivity test for evaluation of the biological safety of a colored alumina/glass composite (AGC). Methods: colored alumina/glass composite and control materials were sutured to mucine bilateral cheek pouch mucosa, in a position for gross observation and for histological and cytological examination; skin irritation activity of the composite was tested by intradermal injection of a guinea pig test solution, by inducing, enhancing, and stimulating the allergic response observed after local tissue exposure. Results: col

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Arcimowicz, Magdalena, and Edyta Krzych-Fałta. "Nasal allergen challenge - an important tool in diagnosis of rhinologic disease." Polski Przegląd Otorynolaryngologiczny 9, no. 4 (2020): 1–5. http://dx.doi.org/10.5604/01.3001.0014.6068.

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The nasal allergen challenge (NAC) is used in the diagnosis of rhinitis. The primary use of NAC is to confirm allergy to a specific inhaled allergen. NAC reproduces the allergic reaction of the nasal mucosa under standardized and controlled conditions that occurs after direct intranasal administration of allergens. As the only used method for assessing the degree of allergy, it mimics the body’s natural response to the sensitizing factor in the early and late stages of an allergic reaction. NAC is used in the diagnosis of chronic, occupational and local rhinitis, as well as in the differential

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Franchini, Anthony, Todd Reinhart, Cristy Stagnar, Amithi Narendran, and Deborah Fuller. "Co-delivery of genetic adjuvants enhances mucosal immune responses induced by PMED DNA vaccination (46.15)." Journal of Immunology 184, no. 1_Supplement (2010): 46.15. http://dx.doi.org/10.4049/jimmunol.184.supp.46.15.

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Abstract Mucosal immune responses play a vital role in protecting against natural influenza infection. We have shown that particle mediated epidermal delivery (PMED) of a DNA vaccine induces systemic and mucosal immune responses. PMED results in the direct transfection of epidermal cells, including skin-resident Langerhans cells (LC) to induce an immune response. Inclusion of a DNA plasmid expressing the heat-labile enterotoxin (LT) of E. coli improves systemic immune responses. We hypothesize that LT and other genetic adjuvants would similarly enhance the mucosal immunogenicity of PMED DNA va

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Shigematsu, Hiroaki, Kenichi Kumagai, Motoaki Suzuki, et al. "Cross-Reactivity of Palladium in a Murine Model of Metal-induced Allergic Contact Dermatitis." International Journal of Molecular Sciences 21, no. 11 (2020): 4061. http://dx.doi.org/10.3390/ijms21114061.

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Metal allergy is usually diagnosed by patch testing, however, the results do not necessarily reflect the clinical symptoms because of cross-reactivity between different metals. In this study, we established the novel mouse model of cross-reactive metal allergy, and aimed to elucidate the immune response in terms of T-cell receptor repertoire. This model was classified into two groups: the sensitization to nickel and challenge with palladium group, and the sensitization to chromium and challenge with palladium group. This model developed spongiotic edema with intra- and peri-epithelial infiltra

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Basso, Lilian, Nadine Serhan, Marie Tauber, and Nicolas Gaudenzio. "Peripheral neurons: Master regulators of skin and mucosal immune response." European Journal of Immunology 49, no. 11 (2019): 1984–97. http://dx.doi.org/10.1002/eji.201848027.

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Gangur, Venugopal, Haoran Gao, Rick Dean Jorgensen, et al. "Evaluation of salt-soluble protein extract from an ancient wheat progenitor (Aegilops tauschii) for intrinsic allergenicity in an adjuvant-free mouse model of wheat allergy." Journal of Immunology 210, no. 1_Supplement (2023): 151.15. http://dx.doi.org/10.4049/jimmunol.210.supp.151.15.

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Abstract Wheat allergies are a growing significant health concern around the globe. The ancient diploid wheat progenitor, Aegilops tauschii (genome DD), contributed to the genetic diversity of the common soft white wheat (Triticum aestivum, genomes AABBDD). The allergenic potential of Ae. tauschii is largely unknown. Here we tested the hypothesis that the the salt-soluble protein extract (SSPE) from Ae. tauschii will be intrinsically allergenic in an adjuvant-free mouse model of wheat allergy. The ancient wheat progenitor was grown at the Michigan State University greenhouse using the seeds st

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Janosevic, Ljiljana, Slobodanka Janosevic, P. Stankovic, et al. "Klasifikacija hronicnih inflamacija gornjih disajnih puteva na bazi alergijskog statusa." Acta chirurgica Iugoslavica 51, no. 1 (2004): 88–92. http://dx.doi.org/10.2298/aci0401088j.

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Almost one third to one half of all patients in otorhinolaryngologic practice experience some kind of inflammation of the upper respiratory tract out of which allergic mechanisms, either as primary factors or secondary ones, appear in 30-40% of adults and 60-80% of children and adolescents. The objective of this study was to analyze inflammatory conditions of the upper airways on the basis of allergic state of the patient and to establish the classification that will respect the actual immunological alteration level (subclinical allergy, clinical allergy) and spreading (localized allergy, gene

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Sankovic-Babic, Snezana, Marina Atanaskovic-Markovic, and Rade Kosanovic. "ALLERGY AND SECRETORY OTITIS MEDIA." Acta Medica Saliniana 37, no. 2 (2008): 166–70. http://dx.doi.org/10.5457/ams.v37i2.17.

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Introduction: According to recent studies the role of allergy in ethipathogenesis of secretory otitis media is the leading one.The incidence of allergy in secretory otitis media varies from 57% to 100% according to recent studies.The allergic inflammation of the middle aer mucosa is of Th 2 type inflammation of respiratory mucosa.Increased number of activated mast cells, mastocyte tryptase, eosinophyllic cationic protein and mRNA for IL 5 were found in mucosa and effusion in SOM. The aim of this sudy was to investigate the presence of allergies in children with secertory otitis media and to fo

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Ishida, Mariko, Shoji Matsune, Nozomu Wakayama, Ryuji Ohashi, and Kimihiro Okubo. "Possibility of Local Allergic Rhinitis in Japan." American Journal of Rhinology & Allergy 34, no. 1 (2019): 26–34. http://dx.doi.org/10.1177/1945892419868441.

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Background The concept of local allergic rhinitis (LAR) has been advocated recently. Allergic rhinitis in Japan is characterized by house dust mites (HDMs) and Japanese cedar pollen (JCP). To investigate LAR in Japan, total IgE and antigen-specific IgE (sIgE) were measured in inferior turbinate mucosa and their relationships with skin test (ST) and nasal allergen provocation test (NAPT) and as well as serum IgE levels were examined. Methods Subjects were 50 rhinosinusitis patients for surgery. ST was performed and serum total IgE and sIgE levels were measured preoperatively. Patients with clas

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Ni Luh Sartika Sari, Putu Yupindra Pradiptha, and Steven Yohanis Latupeirissa. "Diagnosis and management of allergic rhinitis in pediatric patient: A case report." GSC Biological and Pharmaceutical Sciences 30, no. 1 (2025): 233–38. https://doi.org/10.30574/gscbps.2025.30.1.0019.

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Background: Allergic rhinitis (AR) is a prevalent chronic condition affecting children and adults worldwide, with significant impacts on quality of life and daily functioning. Accurate diagnosis and effective management are essential to mitigate symptoms and improve outcomes. Objective: To report a case of allergic rhinitis in pediatric patient. Case Report: A 7-year-old female presented with a one-year history of left nasal obstruction, intermittent nasal bleeding, rhinorrhea, and sneezing exacerbated by dust exposure. History of allergy was present in family. Nasal endoscopy revealed mucosal

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Hamizan, Aneeza, Raquel Alvarado, Janet Rimmer, et al. "Nasal mucosal brushing as a diagnostic method for allergic rhinitis." Allergy and Asthma Proceedings 40, no. 3 (2019): 167–72. http://dx.doi.org/10.2500/aap.2019.40.4209.

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Background: Allergen specific immunoglobulin E (spIgE) in the nasal mucosa is a biomarker for local allergic rhinitis. Inferior turbinate tissue biopsy is a sensitive method to detect nasal spIgE but is invasive. Nasal brushing is a relatively noninvasive method to detect nasal spIgE that may be of comparable diagnostic utility. Objective: To assess the performance of nasal brushing to obtain a nasal spIgE sample compared with an inferior turbinate tissue biopsy among patients who underwent turbinate surgery. Methods: A diagnostic cross-sectional study that involved participants who were under

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Laird, Renee, Sakina Shahabudin, Kristen Clarkson, et al. "Memory B cells with gut-homing potential are generated by a prototype anti-enterotoxigenic E. coli vaccine given by intradermal immunization with LT(R192G) as an adjuvant (MUC3P.945)." Journal of Immunology 194, no. 1_Supplement (2015): 66.4. http://dx.doi.org/10.4049/jimmunol.194.supp.66.4.

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Abstract Lymphocytes that express α4β7 integrin can home to the gut mucosa through interactions with MAdCAM-1 addressin on the intestinal endothelium. α4β7+ Ag-specific plasmocytes and memory B (BM) cells can be found after infection or experimental challenge with enteric pathogens as well as mucosal immunization, yet gut-homing B cells have not been reported in high frequencies in humans after parenteral immunization. Intradermal (ID) immunization is an attractive delivery route for enteric vaccines due to a potential connection between the skin and gut. Mucosal responses may be further enhan

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Salinas, Irene, Elisa Casadei, Fumio Takizawa, Yasuhiro Shibasaki, and Oriol J. Sunyer. "Interactions between microbiota and the teleost immune system in health and disease." Journal of Immunology 200, no. 1_Supplement (2018): 53.19. http://dx.doi.org/10.4049/jimmunol.200.supp.53.19.

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Abstract The symbiosis between metazoans and prokaryotes is one of the most ancient and successful relationships found in nature. Mucosal surfaces are the main interface between animal hosts and their environment, and these surfaces are colonized by unique microbial communities that shape every physiological system of the host. Teleost fish have both an innate and adaptive immune system and are the most ancient vertebrates with a dedicated mucosal immunoglobulin (Ig), known as IgT/IgZ. IgT is secreted via the polymeric Ig receptor across teleost mucosal epithelia, including the gills, skin, no

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Duverger, Alexandra, Wei-Jen Tang, Stephen H. Leppla, and Prosper N. Boyaka. "Differential regulation of mucosal immunity by Bacillus anthracis edema toxin and cholera toxin as adjuvants for transcutaneous vaccines (41.3)." Journal of Immunology 178, no. 1_Supplement (2007): S30. http://dx.doi.org/10.4049/jimmunol.178.supp.41.3.

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Abstract Our previous studies have shown that nasal co-administration of an anthrax edema toxin (EdTx) derivative [i.e., protective antigen (PA) plus an edema factor (EF) mutant (EF N447S)], enhances mucosal and systemic immunity to both PA and co-administered unrelated protein antigen. Unlike the ganglioside targeting adjuvant, cholera toxin (CT), nasal EdTx N447S did not target CNS tissues or induce inflammatory responses in the NALT. Here, we examined whether the difference in the cell targeting of these two adjuvants would lead to different mucosal and systemic Ab responses when used in tr

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Labuz, Daniel, Irma D. Fleming, Giavonni Lewis, Callie M. Thompson, and Daniel T. Leung. "Human skin mucosal associated invariant T (MAIT) cells show increased pro-inflammatory cytokine expression following burn trauma." Journal of Immunology 206, no. 1_Supplement (2021): 55.09. http://dx.doi.org/10.4049/jimmunol.206.supp.55.09.

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Abstract The role of T cells in burn trauma is an understudied research area explored primarily in mice, with sparse data in humans. Patients surviving an initial burn injury are at a high risk of infection, sepsis, and death. Unconventional T-cells such as mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that respond rapidly to pathogens. Circulating MAIT cells are primarily interferon (IFN)-gamma and tumor necrosis factor (TNF) producing when presented with a microbial-derived ligand on MHC class-1 related protein (MR1) or activated by cytokines interleukin (IL)-12 &am

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Kamimura, Mitsuhiro, Hiroaki Todo, Kenji Sugibayashi, and Koichiro Asano. "Topical Percutaneous Drug Delivery for Allergic Diseases: A Novel Strategy for Site-Directed Pharmacologic Modulation." Pharmaceutics 17, no. 7 (2025): 867. https://doi.org/10.3390/pharmaceutics17070867.

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Topical percutaneous drug delivery has recently emerged as a novel strategy for the treatment of allergic diseases, offering targeted drug delivery to mucosal tissues adjacent to the skin. Unlike conventional topical approaches that act on the skin surface or mucosal membranes, topical percutaneous drug delivery enables non-invasive pharmacologic modulation of deeper structures such as the conjunctiva, nasal mucosa, and trachea. This review explores the rationale, pharmacokinetic foundation, clinical data, and future prospects of transdermal therapy in allergic conjunctivitis, allergic rhiniti

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Lee, Heung Kyu, Melodie Zamora, Melissa M. Linehan, et al. "Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection." Journal of Experimental Medicine 206, no. 2 (2009): 359–70. http://dx.doi.org/10.1084/jem.20080601.

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Although mucosal surfaces represent the main portal of entry for pathogens, the mechanism of antigen presentation by dendritic cells (DCs) that patrol various mucosal tissues remains unclear. Instead, much effort has focused on the understanding of initiation of immune responses generated against antigens delivered by injection. We examined the contributions of migratory versus lymph node–resident DC populations in antigen presentation to CD4 and CD8 T cells after needle injection, epicutaneous infection, or vaginal mucosal herpes simplex virus (HSV) 1 infection. We show that upon needle injec

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Nur'aeny, Nanan. "ORAL ALLERGY SYNDROME (OAS) AKIBAT REAKSI ALERGI MAKANAN." B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah 2, no. 2 (2018): 125–32. http://dx.doi.org/10.33854/jbdjbd.20.

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Allergic condition such as itching of the skin, or runny nose and sneezing are widely known, but different case of allergic reaction in the mouth. Are still unknown, one of them is Oral Allergy Syndrome (OAS). Almost everyone knows food allergens such as shrimp, or marine fish, but actually fresh fruits and vegetables also can trigger allergic reactions like OAS in the form of itching or swelling of the lips, tongue, palate, and pharynx. Author intends to provide further information about the OAS in this paper. The mechanism of OAS is a type I, immunoglobulin E-mediated hypersensitivity reacti

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Panayotova, M., and M. Penkova. "Measurement of oxidative stress-related markers in gastro-intestinal damages in Bulgarian pediatric patients." Bulgarian Chemical Communications 56, no. D1 (2024): 142–47. http://dx.doi.org/10.34049/bcc.56.d.s1p54.

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Cow's milk allergy (CMA), affects ~2 - 7.5% of the infants, and results in an immunological response to casein and α-/β-lactalbumins such as: skin rashes, respiratory and gastrointestinal disturbances. Inflammatory bowel disease (IBD), affecting adolescents, is sustained by an impaired immune/ inflammatory response against intestinal microorganisms. Reactive oxygen/nitrogen (ROS/RNS) overproduction in the gastrointestinal tract damages the mucosa in CMA and IBD. The aim of the present study was to determine ROS/RNS and oxidative disturbances in the intestinal mucosa influence in CMA and IBD. W

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Rebrikova, I. V., E. A. Vorotelyak, O. S. Rogovaya, et al. "Hypopharyngeal reconstruction using prelaminated autologous bio-engineered pectoralis major flaps." Russian Journal of Transplantology and Artificial Organs 24, no. 4 (2022): 135–44. http://dx.doi.org/10.15825/1995-1191-2022-4-135-144.

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After removal of metastatic malignant tumors of the hypopharynx and larynx, hypopharyngeal defects are formed. To restore the hypopharynx, a mucosa and a muscular component are needed.The objective of this study is to develop a hypopharyngeal reconstruction technique using prelaminated pectoralis major flap with mucosal epithelium analogue from autologous epithelial layers.Materials and methods. Nine patients underwent reconstruction of the hypopharynx using bioengineered prelaminated pectoralis major flaps. The mucosa was restored by tissue-engineered autologous epithelial cell layers that we

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Olga, Pakholchuk. "Prevalence and correlative-statistical interrelation of the dysfunction of the intestinal mucosal barrier in children with symptoms of the food hypersensitivity." ScienceRise: Medical Science, no. 5(25) (September 28, 2018): 36–39. https://doi.org/10.15587/2519-4798.2018.139736.

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Food intolerance (FI) in children is one of the most common manifestations of allergy in early childhood, which is confirmed by the results of many epidemiological studies. Studies have shown that the degree of permeability of the intestinal wall is an important link not only in the pathogenesis of FI, but also in the formation of processes of immune tolerance and maturation of immunity. <strong>The aim of the study</strong> was to research the prevalence and correlation-statistical relationships of dysfunction of the intestinal barrier in children with symptoms of FI on the skin. <strong

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Di Bari, Silvia, Annalisa Mondi, Carmela Pinnetti, et al. "A Case of Severe Mpox Complicated with Streptococcus pyogenes Sepsis in a Patient with HIV Infection." Pathogens 12, no. 9 (2023): 1073. http://dx.doi.org/10.3390/pathogens12091073.

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Since May 2022, a global outbreak of human Mpox has rapidly spread in non-endemic countries. We report a case of a 34-year-old man admitted to hospital for a six-day history of fever associated with vesiculo-pustular rash involving the face, limbs, trunk and perianal region, lymphadenopathy and severe proctitis and pharyngitis. He was HIV-positive and virologically suppressed by stable antiretroviral therapy. On admission, Mpox virus-specific RT-PCR was positive from multiple samples. Additionally, blood cultures yielded Streptococcus pyogenes, prompting a 14-day-course of penicillin G and cli

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Ferraro, Valentina Agnese, Stefania Zanconato, and Silvia Carraro. "The Epithelial Barrier Hypothesis in Food Allergies: The State of the Art." Nutrients 17, no. 6 (2025): 1014. https://doi.org/10.3390/nu17061014.

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Recently, the “epithelial barrier hypothesis” has been proposed as a key factor in the development of allergic diseases, such as food allergies. Harmful environmental factors can damage epithelial barriers, with detrimental effects on the host immune response and on the local microbial equilibrium, resulting in chronic mucosal inflammation that perpetuates the dysfunction of the epithelial barrier. The increased epithelial permeability allows allergens to access the submucosae, leading to an imbalance between type 1 T-helper (Th1) and type 2 T-helper (Th2) inflammation, with a predominant Th2

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