Academic literature on the topic 'Skin Diseases, epidemiology'
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Journal articles on the topic "Skin Diseases, epidemiology"
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Safavi, Kayvon. "Data Resources for Epidemiology of Skin Diseases." Journal of Investigative Dermatology 102, no. 6 (June 1994): 51S—53S. http://dx.doi.org/10.1111/1523-1747.ep12388611.
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Taylor, Susan C. "Epidemiology of skin diseases in ethnic populations." Dermatologic Clinics 21, no. 4 (October 2003): 601–7. http://dx.doi.org/10.1016/s0733-8635(03)00075-5.
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Graham-Brown. "Epidemiology, Causes and Prevention of Skin Diseases." British Journal of Dermatology 140, no. 2 (February 1999): 378. http://dx.doi.org/10.1046/j.1365-2133.1999.140002378.x.
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Dardick, Kenneth. "Imported Skin Diseases." Emerging Infectious Diseases 14, no. 6 (June 2008): 1008. http://dx.doi.org/10.3201/eid1406.080223.
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Alwan, Naseer K., Shahab A. Shakir, and Hayder H. Waheeb. "Epidemiology of Skin Diseases among Displaced People in Diyala Province." Journal of the Faculty of Medicine Baghdad 60, no. 1 (April 1, 2018): 52–56. http://dx.doi.org/10.32007/jfacmedbagdad.60145.
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Background: Diyala have many internally displaced persons as a consequence of the armed conflict. Those peoples experience serious health problems related to their displacement, including skin disorders.Objective: To determine the prevalence of skin diseases and the use of health care among displaced patients in Diyala.Methods: A case-series study conducted on 246 displaced patients from May to November 2017, who attended Baqubah teaching hospital in Diyala. All patients were diagnosed by dermatologists depending on clinical findings.Results: A total of 246 displaced patient from all age groups mean±SD (21.9±18.59) years, range 1-64) consulate the clinic, of them (29.3%) male and (70.7%) female with male to female ratio (1:2.4). Infectious skin diseases have the highest rate (65.9%), followed by dermatitis (18.4%), acne (5.7%), alopecia (5.3%), and Papulosquamous diseases (4.8%). Parasitic skin infestations (31.7%) and viral infection (24.4%) were the commonest noted infections. Significant associations present between previous consultation and economic status, and between prevalence of skin infections and low economic status. Significant associations between skin diseases and rising crowding index.Conclusion: Infectious skin diseases are common among displaced patients, significantly higher among low economic status. Skin diseases significantly associated with rising crowding index.
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Alwan, Naseer K., Shahab A. Shakir, and Hayder H. Waheeb. "Epidemiology of Skin Diseases among Displaced People in Diyala Province." Journal of the Faculty of Medicine Baghdad 60, no. 1 (April 1, 2018): 52–56. http://dx.doi.org/10.32007/jfacmedbagdad.v60i1.45.
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Background: Diyala have many internally displaced persons as a consequence of the armed conflict. Those peoples experience serious health problems related to their displacement, including skin disorders.Objective: To determine the prevalence of skin diseases and the use of health care among displaced patients in Diyala.Methods: A case-series study conducted on 246 displaced patients from May to November 2017, who attended Baqubah teaching hospital in Diyala. All patients were diagnosed by dermatologists depending on clinical findings.Results: A total of 246 displaced patient from all age groups mean±SD (21.9±18.59) years, range 1-64) consulate the clinic, of them (29.3%) male and (70.7%) female with male to female ratio (1:2.4). Infectious skin diseases have the highest rate (65.9%), followed by dermatitis (18.4%), acne (5.7%), alopecia (5.3%), and Papulosquamous diseases (4.8%). Parasitic skin infestations (31.7%) and viral infection (24.4%) were the commonest noted infections. Significant associations present between previous consultation and economic status, and between prevalence of skin infections and low economic status. Significant associations between skin diseases and rising crowding index.Conclusion: Infectious skin diseases are common among displaced patients, significantly higher among low economic status. Skin diseases significantly associated with rising crowding index.
وبائية الامراض الجلدية بين النازحين في محافظة ديالى
د. نصير كريم علوان دائرة صحة ديالى
د. شهاب احمد شاكر كلية الطب جامعة ديالى
حيدر حميد وهيب دائرة صحة ديالى
خلفية الدراسة: نتيجة العنف والنزاع المسلح في ديالى، نزح عدد كبير من الناس فيها. تعاني هذه المجموعات من مشاكل صحية كبيرة تتعلق بنزوحها، بما في ذلك الأمراض الجلدية.
هدف الدراسة: هذه الدراسة تهدف الى تحديد انتشار الامراض الجلدية بين النازحين في ديالى ومدى استخدام خدمات الرعاية الصحية لعلاجها.
الطريقة: دراسة استطلاعية أجريت على ٢٤٦ نازح من المرضى الذين راجعوا قسم الأمراض الجلدية في مستشفى بعقوبة التعليمي في محافظة ديالى للفترة من ١ مايو إلى ٣٠ نوفمبر ٢٠١٧ واستند التشخيص على الصورة السريرية للمرض.
النتائج: خلال فترة الدراسة شُخّص ٢٤٦ نازح بإمراض جلدية مختلفة، تراوحت أعمارهم بين ١-٦٤ سنة، متوسط العمر (٩.٢١) سنة، كانت نسبة الذكور الى الاناث (١: ٢.٤)، ١٧٤ من الإناث (٧٠.٧٪) و٧٢ من الذكور (٢٩.٣٪). وكان المرض الجلدي الأكثر انتشاراً في كل من الذكور والإناث هو الالتهابات الجلدية المعدية (٦٥.٩٪)، يتبعه الأكزيما (١٨.٤٪)، ومن ثم حب الشباب (٥.٧٪) على التوالي. ومثلت الالتهابات الطفيلية أعلى نسب انتشار من بين الالتهابات الجلدية المعدية (٣١.٧٪)، تليها الالتهابات الفيروسية (٢٤.٤٪). أظهرت النتائج علاقة وثيقة بين نسبة انتشار الامراض الجلدية المعدية والحالة الاقتصادية للمرضى، وبين المراجعة لعلاج المرض والحالة الاقتصادية. وجدت الدراسة أيضا علاقة وثيقة بين انتشار الامراض الجلدية المعدية وارتفاع مؤشر ازدحام السكن.
الاستنتاج: الأمراض الجلدية المعدية شائعة بين المرضى النازحين، وهي تزداد بين المرضى ذوي الدخل المحدود. الأمراض الجلدية تؤثر على جميع الفئات العمرية، وترتبط بشكل كبير مع ارتفاع مؤشر ازدحام السكن.
مفتاح الكلمات: الامراض الجلدية، النازحين، مؤشر الزحام.
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Kirsten, Natalia, Nicole Mohr, Aminah Alhumam, and Matthias Augustin. "Prevalence and Associated Diseases of Seborrheic Skin in Adults." Clinical Epidemiology Volume 13 (September 2021): 845–51. http://dx.doi.org/10.2147/clep.s323744.
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Chen, Qi Ping, and Derrick CW Aw. "Epidemiology of Skin Diseases in Renal Transplant Recipients in a Tertiary Hospital." Annals of the Academy of Medicine, Singapore 39, no. 12 (December 15, 2010): 904–8. http://dx.doi.org/10.47102/annals-acadmedsg.v39n12p904.
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Introduction: There is no published epidemiological data on skin diseases in kidney transplant recipients in this tropical country, which has multi-ethnic groups with the Chinese as the predominant ethnic group. Materials and Methods: Skin diseases of 143 renal transplant recipients were studied in a skin clinic of a tertiary institution during annual surveillance visits from June 2006 to March 2009. Results: Our study showed that except the common drug specific skin manifestations, sebaceous hyperplasia (56.6%), seborrheic keratosis (60.8%), melanocytic naevi (76.9%), skin tags (37.1%) and viral (29.4%) and fungal (20.3%) infections were the most prevalent skin diseases among renal transplant recipients living in Singapore. The prevalence of pre-malignant and malignant tumours was very low (11.2% actinic keratosis, 1.4% Bowen’s disease, 1.4% squamous cell carcinoma, 0.7% basal cell carcinoma, 0.7% keratoacanthoma). Male predominance was seen in sebaceous hyperplasia (72.4% vs 32.1%), actinic keratosis (17.2% vs 1.8%), viral (36.8% vs 19.6%) and fungal (27.6% vs 8.9%) infections. Our study also showed increased prevalence of sebaceous hyperplasia with increased age but its prevalence was significantly higher than that reported in the age matched general population. The prevalence of seborrheic keratosis, actinic keratosis and viral infection correlated positively with post-transplant duration. Conclusions: Our study provides epidemiological data for the prevalence of skin diseases in renal transplant recipients. It emphasises the importance of dermatologic follow-up for renal transplant patients in order to obtain a diagnosis and manage treatable skin diseases. Keywords: Actinic keratosis, Sebaceous hyperplasia, Seborrheic keratosis
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Jałowska, Magdalena, Marta Szymoniak-Lipska, Ryszard Żaba, and Zygmunt Adamski. "Epidemiology of occupational skin diseases in Poland in the period 2003–2017." Dermatology Review 106, no. 4 (2019): 384–95. http://dx.doi.org/10.5114/dr.2019.88255.
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Jovanovic, Marina. "Current concepts of pathophysiology, epidemiology and classification of pruritus." Srpski arhiv za celokupno lekarstvo 142, no. 1-2 (2014): 106–12. http://dx.doi.org/10.2298/sarh1402106j.
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Discovery of pruritus-specific mediators and receptors facilitated the neurobiological concept of pruritus: itch-specific (histamine-dependent and histamine-independent C-fibers); itch-specific receptors on cutaneous and spinal neurons; ?dialogue? between the pruritus-specific neurons and cells in the skin; peripheral and central mediation of pruritus; functional ?pruritus-specific matrix? in the brain with a role of pruritus center. In 10%-50% of persons without skin diseases, pruritus is considered the manifestation of a systemic disorder. Identification of pruritus within autoimmune and inflammatory diseases in dermatology is based on the clinical picture and nature of the underlying disease, implying the development of pruritus on primarily and/or secondarily inflamed skin. In the internal medicine, pruritus commonly presents on primarily non-inflamed skin., involvement of the skin and gastrointestinal tract are two independent risk factors of pruritus in systemic sclerosis, and of anal/vulvar pruritus. Classification combines etiological and clinical criteria and should be considered the only segment of a comprehensive approach to pruritus of unknown origin.
Dissertations / Theses on the topic "Skin Diseases, epidemiology"
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Leino, Timo. "Epidemiology of skin and respiratory diseases among hairdressers." Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/laa/kansa/vk/leino/epidemio.pdf.
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Sinikumpu, S. P. (Suvi-Päivikki). "Skin diseases and their association with systemic diseases in the Northern Finland Birth Cohort 1966." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526217888.
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Abstract Skin diseases are common: one in every three of all general practice patients have at least one dermatological problem. However, epidemiological studies addressing the overall prevalence of skin diseases are sparse. The skin is the largest organ in the body and it has several vital and immunological functions. Cutaneous signs are often the first manifestation of many systemic diseases. The aim of this study was to determine the overall prevalence, and the distribution according to sex and socioeconomic status, of skin diseases in an adult population. The study particularly focused on multiple melanocytic naevi and their risk factors because multiple melanocytic naevi are the strongest risk factor for melanoma. A further aim was to analyse the association between cutaneous disorders and systemic conditions; specifically to determine whether abnormal skin findings in toe webs have an association with abnormal glucose metabolism and whether skin diseases have a relationship with systemic low-grade inflammation. For these purposes a comprehensive dermatological evaluation was performed as a part of the 46-year follow-up survey of the Northern Finland Birth Cohort 1966. Data on this cohort have been collected since birth. Numerous laboratory tests were also performed cross-sectionally during the 46-year follow-up survey, including an oral glucose tolerance test and the measurement of fasting plasma glucose and glycated haemoglobin fraction. High sensitivity C-reactive protein was measured as a marker of low-grade inflammation. Over half (60%) of the 1 932 individuals examined had at least one skin disorder requiring further treatment. The need for treatment was more common in males and those with lower socioeconomic status. Multiple melanocytic naevi were found in 12% of individuals; high educational level, male sex and fair skin type increased the risk. Abnormal skin findings in toe web spaces was associated with undiagnosed type 2 diabetes. Atopic eczema, rosacea and onychomycosis were associated with low-grade inflammation. This unique study with nearly 2 000 subjects reports for the first time the overall prevalence of skin diseases in an unselected Finnish population. Its findings support the previous postulate that skin diseases are common in adults and suggest that skin evaluation should be an essential part of routine medical examinations in clinical practiceTiivistelmä Ihotaudit ovat yleisiä, ja jopa 30 %:lla yleislääkärin potilaista on jokin ihoon liittyvä ongelma. Väestötason tutkimuksia ihotaudeista on kuitenkin niukasti. Iho on ihmisen suuri elin, ja sillä on useita tärkeitä tehtäviä, kuten osallistuminen immunologiseen puolustukseen. Monet yleissairaudet voivat näkyä iholla jo ennen taudin puhkeamista ja ihoilmentymät voivat olla varhaisia merkkejä piilevästä sairaudesta. Tämän tutkimuksen tarkoituksena oli määrittää ihotautien esiintyvyys aikuisväestössä sekä ihotautien jakautuminen sukupuolen ja sosiaalisen aseman suhteen. Lisäksi tarkoituksena oli selvittää runsasluomisuuden (yli 50 pigmenttiluomea) esiintyvyyttä ja sen riskitekijöitä, sillä runsasluomisuus on melanooman merkittävin riskitekijä. Tutkimuksen tavoitteena oli myös selvittää ihotautien yhteyttä yleissairauksiin, kuten poikkeavien varvasvälilöydösten yhteyttä häiriintyneeseen sokeriaineenvaihduntaan sekä matala-asteisen tulehduksen ja ihotautien välistä yhteyttä. Osana Pohjois-Suomen syntymäkohortti 1966:n 46-vuotistarkastusta tehtiin kokonaisvaltainen ihon tutkiminen yhteensä 1 932:lle tutkimushenkilölle vuosina 2012–13. Samassa yhteydessä tutkittavilta määritettiin paastoverensokeri ja pitkäaikainen verensokeri sekä tehtiin sokerirasitustesti sokeriaineenvaihdunnan häiriön toteamiseksi. Matala-asteisen tulehduksen arvioimiseksi määritettiin herkkä C-reaktiivinen proteiini. Tutkimusjoukon pitkäaikaiset taustatiedot perustuivat syntymäkohortin aiempiin aineistoihin. Tutkittavista 60 %:lla todettiin jokin hoitoa vaativa ihotauti. Hoidon tarve oli suurempaa miehillä ja matalammissa sosiaaliluokissa. Runsasluomisuutta esiintyi 12 %:lla, ja korkea koulutustaso, miessukupuoli ja vaalea ihotyyppi lisäsivät riskiä. Varvasväleissä esiintyvät muutokset liittyivät diagnosoimattomaan diabetekseen. Atooppinen ihottuma, ruusufinni ja kynsien sieni-infektioon sopivat muutokset olivat yhteydessä matala-asteiseen tulehdukseen. Tämä lähes 2 000 henkilön koko ihon kliiniseen tutkimukseen perustuva työ raportoi ensimmäistä kertaa ihotautien yleistä esiintyvyyttä suomalaisessa, valikoitumattomassa väestössä. Tutkimus tukee aiempaa oletusta, jonka mukaan ihotaudit ovat aikuisväestössä yleisiä; ihon tutkiminen tulisi olla oleellinen osa potilaan kliinistä perustutkimusta
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Medic, Sandra. "New perspectives on melanoma: The role of PAX3." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2011. https://ro.ecu.edu.au/theses/414.
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Background: Cutaneous melanoma is an aggressive form of skin cancer, arising in cutaneous melanocytes. The transcription factor PAX3 is critical for the proper development of neural crest lineages including melanocytes. Melanocytic cells show continued PAX3 expression from melanoblast formation in the neural crest to their differentiation into melanocytes. While many studies clarify the importance of PAX3 in embryonic development of melanocytes, less well understood, and more perplexing, is the continued PAX3 expression in adult skin melanocytes. By contrast PAX3 is frequently found in melanomas and naevi, and its expression correlates with melanoma staging. In this study we explore the multiple roles of PAX3 in melanocyte genesis and melanoma progression. While PAX3 is known to regulate melanocyte differentiation, survival, proliferation and migration during embryonic development, it is not clear if these same functions are maintained in adult melanocytes or melanoma cells. Drawing on evidence from development, we propose here a more encompassing theory that PAX3 is a key regulator of the myriad steps in melanocytic cell determination and function. We discuss the possibility that these roles may be accomplished by differential association with cofactors, via alternate transcripts or posttranslational protein modification(s). Moreover, we consider its possible roles in melanoma and provide a comprehensive consideration of the significance of PAX3 expression in melanoma.
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Amarante, Cristina Fernandes do. "An?lise epidemiol?gica das dermatopatias de uma popula??o canina atendida no per?odo de 2005 a 2010 no Setor de Dermatologia do Hospital Veterin?rio da Universidade Federal Rural do Rio de Janeiro." Universidade Federal Rural do Rio de Janeiro, 2012. https://tede.ufrrj.br/jspui/handle/jspui/1780.
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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES
In Brazil, epidemiological studies on canine dermatopathies are scarce and the literature point out several gaps in knowledge about. The aim of this study was to describe the profile of canine population with dermatopathies attended by the Section of Dermatology, Rural Federal University of Rio de Janeiro, testing associations with variables inherent to animals, eating habits, hygiene and in relation to concurrent dermatopathies. The records of all animals attended between January 2005 and December 2010 were organized in a database using the software Epi Info? version 3.5.1. The Chi-square ?? test or Fisher?s exact test, the prevalence ratios and their confidence intervals, the ?? test for linear trend and the respective Odds ratios were used to evaluate the associations. The level of significance adopted was 5%. We reviewed the records of 2,280 dogs, with a total of 3,433 diagnostics, and 113 types of dermatopathies were identified. The population studied was composed predominantly of females (55.2%), adults (58.3%) and defined breed animals (67.32%). The categories of dermatopathies more prevalent were: allergic (41.35%), bacterial (23.94%) and endocrines (22.41%). The categories not zoonotic (94.12%) predominated over zoonotic diseases (5.88%). The more prevalent dermatitis were: atopic dermatitis - AD (31.67%), hypothyroidism (20.75%), bacterial folliculitis (8.42%), demodicosis (8.29%), flea infestation (7.67%) otitis by M. pachydermatis (6.14%), bacterial otitis (5.92%) and flea allergic dermatitis ? FAD (5.8%). Sex was significantly associated with AD, hepatoid adenoma, acute moist dermatitis - AMD, hypothyroidism, hyperadrenocorticism and demodicosis. Significant differences were observed in relation to age and AD, folliculitis, hypothyroidism, hyperadrenocorticism, scabiosis, demodicosis, dermatophytosis, systemic lupus erythematosus and neoplasms. The prevalence of AD, FAD, contact dermatitis, hypothyroidism, scabiosis, discoid lupus erythematosus, otohematoma and neoplasms varied with significant differences in relation to animal breed. In addition, there are statistical evidences of association between: AD and hypothyroidism, use of perfumes and cleaning products; FAD and AD, food allergic dermatitis and type of food; AMD and neutering, hair type and AD; hypothyroidism and neutering; demodicosis, hair type and neutering; sporotrichosis and contact with injuried animals. The study population is characterised by high prevalence of dermatopathies of the categories allergic, bacterial, endocrines, fungal and parasitic diseases and low prevalence of dermatozoonoses. The nosology of the population studied is consistent with the type of service offered by the Section of Dermatology, which is most seek for solving complex problems and in several occasions by private practitioners. It should be noted that the studied population was examined by a dermatologist from an University Veterinary Hospital where the technology could overcome the private clinics. Therefore, despite the validity of results, these should not be extrapolated without care for other populations. The variety of the diagnostics performed indicates that the diagnosis and management of dermatopathies must receive higher attention from graduates and specialists
No Brasil, estudos epidemiol?gicos sobre dermatopatias caninas s?o escassos e a literatura aponta v?rias lacunas no conhecimento. O objetivo deste estudo foi descrever o perfil da popula??o canina atendida no Setor de Dermatologia da Universidade Federal Rural do Rio de Janeiro, e das dermatopatias, testando-as quanto ?s associa??es com vari?veis inerentes aos animais, seus h?bitos alimentares, higi?nicos e em rela??o ?s dermatopatias concorrentes. Os dados de todos os prontu?rios de animais atendidos no per?odo de janeiro de 2005 a dezembro de 2010 foram armazenados em um banco de dados elaborado no programa Epi Info? vers?o 3.5.1. O teste ?? ou exato de Fisher, as raz?es de preval?ncias e seus respectivos intervalos de confian?a, o ?? de tend?ncia linear e as respectivas odds ratio foram empregados na avalia??o da associa??o. O n?vel de signific?ncia adotado foi de 5%. Foram revisados os prontu?rios de 2.280 c?es, nos quais foram realizados 3.433 diagn?sticos e identificadas 113 dermatopatias diferentes. A popula??o estudada foi composta predominantemente por f?meas (55,2%), adultos (58,3%) e animais com ra?a definida (67,32%). As categorias de dermatopatias mais prevalecentes foram: as al?rgicas (41,35), as bacterianas (23,94%) e as end?crinas (22,41%). As categorias n?o zoon?ticas (94,12%) prevaleceram sobre as zoon?ticas (5,88%). As dermatites mais prevalecentes foram: dermatite at?pica- DA (31,67%), hipotireoidismo (20,75%), foliculite bacteriana (8,42%), demodicose (8,29%), infesta??o por pulga (7,67%) otite por M. pachydermatis (6,14%), otite bacteriana (5,92%) e dermatite al?rgica por picada de pulga- DAPP (5,8%). O sexo esteve associado significativamente a DA, ao adenoma hepat?ide, a dermatite ?mida aguda- DUA, ao hipotireoidismo, ao hiperadrenocorticismo e ? demodicose. Diferen?as significativas foram observadas em rela??o ? idade e a DA, ? foliculite, ao hipotireoidismo, ao hiperadrenocorticismo, ? escabiose, ? demodicose, ? dermatofitose, ao l?pus eritematoso sist?mico, e as neoplasias. As preval?ncias de DA, DAPP, dermatite por contato, hipotireoidismo, escabiose, l?pus eritematoso disc?ide, otohematoma e neoplasias variaram com diferen?as significativas em rela??o ? ra?a. H? evid?ncias estat?sticas de associa??o entre: DA e hipotireoidismo, uso de perfumes e produtos de limpeza; DAPP e DA, dermatite al?rgica alimentar e tipo de alimento; DUA e castra??o, tipo de pelagem e DA; hipotireoidismo e castra??o; demodicose, tipo de pelagem e castra??o; esporotricose e contactantes com les?o. A popula??o estudada caracteriza-se por apresentar altas preval?ncias de dermatopatias nas categorias al?rgicas, bacterianas, end?crinas, parasit?rias e f?ngicas e baixas preval?ncias de dermatozonoses. O quadro nosol?gico da popula??o ? coerente com o tipo de servi?o oferecido pelo setor de dermatologia, que ? mais procurado para resolver problemas complexos e em muitas ocasi?es por indica??o de cl?nicos gerais. Deve-se ressaltar que popula??o estudada foi examinada por dermatologista em Hospital Veterin?rio de uma Universidade onde a capacidade tecnol?gica pode superar a da maioria das clinicas privadas. Portanto, apesar da validade interna dos resultados obtidos, estes n?o devem ser extrapolados sem os devidos cuidados para outras popula??es. A variedade de diagn?sticos realizados indica que o diagn?stico e o manejo das dermatopatias devem receber maior aten??o por parte dos graduandos e especialistas
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Försti, A. K. (Anna-Kaisa). "Incidence, mortality, comorbidities, and treatment of bullous pemphigoid in Finland." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526215310.
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Abstract Bullous pemphigoid (BP) is an autoimmune skin disease predominantly found in elderly people, which causes blistering of the skin and severe itching. The incidence of BP reported by previous studies has varied greatly between 0.05 and 42.8 per 1 million persons per year. Higher incidences have been reported in Western Europe and the USA, while countries around the Mediterranean have reported lower rates. However, the epidemiology of BP has not previously been studied in any Scandinavian country. The one-year mortality of BP is highly variable with estimates between 11% and 41% worldwide. As for comorbidities, the previous studies have shown that BP is associated with neurological disorders. The aim of this study was to investigate the incidence and mortality of BP in Finland, to assess the treatments used for BP, and the potential contribution of systemic glucocorticoid treatment to the high mortality rate found in BP patients. A further aim was to obtain more specific information about the neurological diseases associated with BP, and to clarify the less studied association with psychiatric disorders. For these purposes, we collected the records of all immunologically confirmed BP patients diagnosed in the Oulu University Hospital between 1985 and 2012, and, for a sub-study III, data for all patients diagnosed with BP in Finnish hospitals between 1987 and 2013. We found that the incidence of BP in Northern Finland has increased over the past two decades to approximately 27 new BP cases per 1 million persons per year. The one-year mortality of BP patients is 17%, and the standardized mortality ratio (SMR) is 7.6. Common comorbidities found in the sample of BP patients were: cardiovascular diseases (76%), neurodegenerative diseases (41%), skin conditions other than BP (37%) and type 2 diabetes (23%). Many neurodegenerative diseases of the central nervous system were associated with BP, as were many psychiatric disorders. The association was strongest between multiple sclerosis (MS) and BP, with MS patients having almost a 6-fold higher risk of BP than controls. The present study reports for the first time the incidence and mortality of BP in Finland, and provides new information about the association between BP and neurological and psychiatric disordersTiivistelmä Rakkulainen pemfigoidi (josta jatkossa käytetään nimitystä pemfigoidi) on autoimmuunisairaus, joka esiintyy yleensä iäkkäillä, ja aiheuttaa ihon rakkulointia ja hankalaa kutinaa. Aiemmissa tutkimuksissa pemfigoidin ilmaantuvuus on vaihdellut 0,05:sta 42,8:aan tapaukseen miljoonaa ihmistä kohden vuodessa. Ilmaantuvuuden on havaittu olevan korkeampi Länsi-Euroopassa, kun taas Välimeren ympäristössä ilmaantuvuus on matalampi. Pemfigoidia sairastavien kuolleisuus vuoden kuluessa diagnoosista vaihtelee noin 11-41%:n välillä. Aiemmat tutkimukset ovat myös osoittaneet, että pemfigoidi liittyy neurologisiin sairauksiin. Pemfigoidin epidemiologiaa ei ole kuitenkaan tutkittu Suomessa tai muissa Pohjoismaissa. Tämän tutkimuksen tarkoituksena oli selvittää pemfigoidin ilmaantuvuus ja kuolleisuus Suomessa, tutkia sen hoitoon käytettyjä lääkkeitä sekä arvioida systeemisen glukokortikoidihoidon osuutta korkeaan kuolleisuuteen. Lisäksi tavoitteena oli saada yksityiskohtaista tietoa pemfigoidiin liittyvistä neurologisista sairauksista ja selvittää lisää aiemmissa tutkimuksissa ristiriitaiseksi jäänyttä yhteyttä psykiatrisiin sairauksiin. Tätä varten keräsimme tiedot kaikista Oulun yliopistollisessa sairaalassa diagnosoiduista, immunologisesti varmennetuista pemfigoiditapauksista vuosilta 1985-2012. Kolmannessa osatyössä käytimme kansallista aineistoa, joka sisälsi kaikkialla Suomessa diagnosoidut pemfigoidia sairastavat potilaat vuosilta 1987-2013. Pemfigoidin ilmaantuvuus kasvoi seuranta-aikana ollen nykyisin Pohjois-Suomessa noin 27 tapausta miljoonaa ihmistä kohden vuodessa. Kuolleisuus vuoden kuluessa diagnoosista oli 17% ja vakioitu kuolleisuussuhde (standardized mortality ratio) 7,6. Yleisiä oheissairauksia pemfigoidia sairastavilla olivat sydän- ja verisuonisairaudet (76%), neurodegeneratiiviset sairaudet (41%), muut ihosairaudet (37%) sekä tyypin 2 diabetes (23%). Tutkimuksessa todettiin, että monet neurogeneratiiviset sairaudet ja monet psykiatriset sairaudet liittyvät pemfigoidiin. Yhteys oli vahvin pesäkekovettumataudin (MS-tauti) ja pemfigoidin välillä, ja MS-tautia sairastavilla riski sairastua pemfigoidiin oli lähes 6-kertainen verrattuna kontrollipotilaisiin. Tämä tutkimus on ensimmäinen, joka raportoi pemfigoidin ilmaantuvuuden ja kuolleisuuden Suomessa. Tutkimus antaa lisäksi uutta tietoa pemfigoidin yhteydestä neurologisiin ja psykiatrisiin sairauksiin
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Chihota, Charles Munyaradzi. "The role of arthropod vectors in the epidemiology of lumpy skin disease." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270423.
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Beddingfield, Frederick Coston. "Melanoma a decision analysis to estimate the effectiveness and cost-effectiveness of screening and an analysis of the relevant epidemiology of the disease /." Santa Monica, CA : RAND, 2002. http://catalog.hathitrust.org/api/volumes/oclc/51441066.html.
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Dinh, Kate H. "Sentinel Lymph Node Biopsy in Elderly Patients with Intermediate Thickness Melanoma: A Masters Thesis." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/778.
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Background: A landmark study suggested that wide excision of intermediate-thickness melanoma with sentinel lymph node biopsy (SLNB) and subsequent completion lymph node dissection (CLND) for regional disease may improve prognostication and disease-free survival (DFS) compared with those undergoing wide excision alone. However, these benefits were relatively small and not associated with an improvement in disease-specific survival (DSS). It remains unknown if SLNB and subsequent treatments are beneficial in elderly patients who have a decreased overall (OS) due to other causes.
Methods: Adults ≥ 70 years of age, who underwent surgical intervention for intermediate-thickness cutaneous melanoma from 2000-2013 were identified from a prospectively-maintained database. Clinicopathologic variables measured included age, gender, anatomic site, histologic type, tumor thickness, ulceration, receipt and result of SLNB, completion of CLND, OS, and DFS.
Results: Ninety-one patients underwent excision of an intermediate-thickness melanoma. Forty-nine patients (54%) received a SLNB. Seven of these biopsies (14%) were positive, and five patients went on to receive CLND. Five-year OS was 41% in patients who did not receive SLNB and 52% in patients who did receive SLNB (p=0.11). DFS was similar between groups independent of receipt of SLNB.
Conclusion: Among elderly patients with intermediate-thickness melanoma, patients who received SLNB had similar 5-year OS and DFS compared with those who did not receive SLNB. Routine SLNB for intermediate-thickness melanoma patients may not significantly change outcomes for this age group, and clinical decision-making should consider individual patient comorbidities and goals of care.
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Dinh, Kate H. "Sentinel Lymph Node Biopsy in Elderly Patients with Intermediate Thickness Melanoma: A Masters Thesis." eScholarship@UMMS, 2005. http://escholarship.umassmed.edu/gsbs_diss/778.
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Background: A landmark study suggested that wide excision of intermediate-thickness melanoma with sentinel lymph node biopsy (SLNB) and subsequent completion lymph node dissection (CLND) for regional disease may improve prognostication and disease-free survival (DFS) compared with those undergoing wide excision alone. However, these benefits were relatively small and not associated with an improvement in disease-specific survival (DSS). It remains unknown if SLNB and subsequent treatments are beneficial in elderly patients who have a decreased overall (OS) due to other causes.
Methods: Adults ≥ 70 years of age, who underwent surgical intervention for intermediate-thickness cutaneous melanoma from 2000-2013 were identified from a prospectively-maintained database. Clinicopathologic variables measured included age, gender, anatomic site, histologic type, tumor thickness, ulceration, receipt and result of SLNB, completion of CLND, OS, and DFS.
Results: Ninety-one patients underwent excision of an intermediate-thickness melanoma. Forty-nine patients (54%) received a SLNB. Seven of these biopsies (14%) were positive, and five patients went on to receive CLND. Five-year OS was 41% in patients who did not receive SLNB and 52% in patients who did receive SLNB (p=0.11). DFS was similar between groups independent of receipt of SLNB.
Conclusion: Among elderly patients with intermediate-thickness melanoma, patients who received SLNB had similar 5-year OS and DFS compared with those who did not receive SLNB. Routine SLNB for intermediate-thickness melanoma patients may not significantly change outcomes for this age group, and clinical decision-making should consider individual patient comorbidities and goals of care.
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Gari, Jimolu Getachewl. "Etude épidémiologique de la dermatose nodulaire contagieuse bovine en Ethiopie et évaluation de son impact économique." Thesis, Toulouse, INPT, 2011. http://www.theses.fr/2011INPT0020/document.
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La dermatose nodulaire contagieuse (DNC) est une des maladies virales les plus importantes économiquement chez les bovins en Ethiopie. Elle est causée par le virus LSD (Lympy skin disease virus) appartenant au groupe des Capripoxvirus. L'objectif de cette thèse est de mieux comprendre l'épidémiologie de cette maladie afin de proposer des méthodes de contrôle et de prévention efficaces et applicables sur le terrain. Cette thèse est construite en cinq chapitres. Le premier chapitre fait une description générale du système de production agricole en Ethiopie et présente nos connaissances actuelles sur ce virus et cette maladie. Le second chapitre est consacré à l'évaluation d'un test d'immunofluorescence indirecte (IFI) pour le diagnostic sérologique à l'aide de méthodes sans gold standard. Le test de séroneutralisation virale a été utilisé comme second test de comparaison. L'analyse à l'aide d'un modèle bayesien a montré que l'IFI présentait une bonne sensibilité (92%) et une bonne spécificité (88%) ce qui suggère que ce test peut être utilisé pour le diagnostic et le dépistage de masse de la Dermatose Nodulaire Contagieuse avec une relativement faible proportion d'erreurs. La possibilité de tester un grand nombre de sérums en IFI est un autre avantage de cette technique pour conduire des études épidémiologiques de grande envergure. La sensibilité et la spécificité de la séroneutralisation virale (SNV) étaient respectivement de 78% et de 97%. En conséquence, le test IFI sera préféré pour un dépistage de masse en raison de sa meilleure sensibilité tandis que le test SNV sera réservé à la confirmation. Une étude épidémiologique transversale a été menée pour estimer la prévalence de la Dermatose Nodulaire Contagieuse Bovine à l'échelle du troupeau et de l'individu et pour définir les facteurs de risque associés à cette maladie dans le contexte particulier de l'Ethiopie. C'est l'objet de la troisième partie de cette thèse. Un total de 330 questionnaires d'enquêtes a été collecté de 44 associations paysannes situées dans 15 districts. La prévalence moyenne de la DNC à l'échelle du troupeau était de 42,8% (IC à 95% : 37,5 – 48,3). Elle était significativement plus élevée dans les zones d'altitude moyenne 55,2% (IC à 95% : 47,5 – 62,6) que dans les zones de basse altitude (22,3%) ou les zones de haute altitude (43,5%). La prévalence de la DNC et la mortalité due à cette maladie, observées à l'échelle de l'animal, étaient de 8,1% et de 2,12% respectivement. A nouveau, elles étaient plus élevées dans les zones d'altitude moyenne (10,4% et 3,2% respectivement) que dans les zones de basse et haute altitude (P < 0,05). L'analyse de facteurs de risque a montré que trois variables étaient significativement associées avec la prévalence de la DNC : l'effet de la zone agroclimatique, la conduite de troupeaux différents sur les mêmes pâtures et les mêmes lieux d'abreuvement et l'introduction de nouveaux animaux. L'incidence maximale de la DNC était concomitante de l'augmentation des populations d'insectes hématophages : cette association dans le temps était significative (coefficient de Spearman de 0,88 ; 0,79 et 0,79 respectivement pour les zones de haute, moyenne et basse altitude). L'évaluation de la faisabilité financière et des bénéfices espérés de la vaccination ont constitué la quatrième partie de la thèseLumpy skin disease (LSD) is one of economically important viral diseases of cattle in Ethiopia caused by Lumpy skin disease virus in the member of the genus Capripox viruses. The objective of this thesis is to better understand the epidemiological features of the disease in order to propose practical and applicable control and prevention options. The thesis is classified in five chapters. The first chapter describes the general agricultural production system in Ethiopia and relates the current knowledge on the virus and the disease as given by the literature.The second chapter deals with the performance of indirect fluorescence antibody test (IFAT) as a serological diagnostic and screening tool that was evaluated using methods without gold standard. Virus neutralization test (VNT) was used as the second test for comparison. The analysis of conditional dependent Bayesian model showed that the IFAT had good accuracy both in sensitivity (92%) and specificity (88%) parameters indicating that it could be used for LSD diagnosis and screening (epidemiological studies, epidemiosurveillance) with less misclassification. Its capacity to run large number of samples per plate just like ELISA could be also taken as an advantage for large epidemiological studies. The sensitivity and specificity of VNT was 78%, 97% respectively. The two tests IFAT and VNT were found conditionally independent on the disease status of the animal. Thus, higher sensitivity and throughput for IFAT would render the test being selected for screening purposes and higher specificity performance of VNT would qualify it to be used as a confirmation test. A cross sectional study was then conducted to estimate the prevalence of LSD at herd and animal-levels and to analyze the risk factors associated with the disease occurrence in Ethiopia. It is presented in the third chapter. A total of 330 questionnaire surveys were collected from 44 peasant associations (PA) distributed in 15 districts. The average herd level LSD prevalence was 42.8% (95% CI: 37.5–48.3) and it was significantly higher in the midland agro-climate 55.2% (95% CI: 47.5–62.6) than in lowland and highland agro-climate zones (22.3% and 43.5%, respectively). The observed LSD prevalence and mortality at animal level were 8.1% and 2.12% respectively which were still higher in the midland zone (10.4% and 3.2%, respectively) than in lowland and highland zones (P< 0.05). The risk factor analysis showed that three variables: the effect of agro-climates, communal grazing/watering management and introduction of new animals were significantly associated with LSD occurrence. The temporal association between LSD occurrence and increase in the biting-fly population was also positively correlated by Spearman rank correlation coefficient (0.88, 0.79 and 0.79 for highland, midland and lowland zones, respectively) and statistically significant. The need to evaluate the financial feasibility and benefit possibly expected of vaccination led us to the fourth component of the thesis
Books on the topic "Skin Diseases, epidemiology"
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C, Williams Hywel, and Strachan David P, eds. The challenge of dermato-epidemiology. Boca Raton: CRC Press, 1997.
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J, Grob J., ed. Epidemiology, causes, and prevention of skin diseases. Oxford: Blackwell Science, 1997.
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Faber, William Richard, R. J. Hay, and B. Naafs. Imported skin diseases. 2nd ed. Chichester, West Sussex: Wiley-Blackwell, 2013.
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Jo-David, Fine, and National Epidermolysis Bullosa Registry (U.S.), eds. Epidermolysis bullosa: Clinical, epidemiologic, and laboratory advances, and the findings of the National Epidermolysis Bullosa Registry. Baltimore: Johns Hopkins University Press, 1999.
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Beddingfield, Frederick Coston. Melanoma: A decision analysis to estimate the effectiveness and cost-effectiveness of screening and an analysis of the relevant epidemiology of the disease. Santa Monica, CA: RAND, 2002.
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Patlak, Margie. Mammography and beyond: Developing technologies for the early detection of breast cancer : a non-technical summary. Edited by National Cancer Policy Board (U.S.). Committee on the Early Detection of Breast Cancer and National Research Council (U.S.). Commission on Life Sciences. Washington, D.C: National Academy Press, 2001.
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Hay, Roderick J., William R. Faber, and Bernard Naafs. Imported Skin Diseases. Wiley & Sons, Incorporated, John, 2012.
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Hay, Roderick J., William R. Faber, and Bernard Naafs. Imported Skin Diseases. Wiley & Sons, Incorporated, John, 2012.
Find full textBook chapters on the topic "Skin Diseases, epidemiology"
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Rzany, Berthold, and Niels Weller. "Epidemiology of Autoimmune Skin Disorders." In Autoimmune Diseases of the Skin, 21–38. Vienna: Springer Vienna, 2001. http://dx.doi.org/10.1007/978-3-7091-3704-8_2.
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Sugita, Takashi, Teun Boekhout, Aristea Velegraki, Jacques Guillot, Suzana Hađina, and F. Javier Cabañes. "Epidemiology of Malassezia-Related Skin Diseases." In Malassezia and the Skin, 65–119. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-03616-3_3.
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Klement, Eyal. "Epidemiology and Transmission." In Lumpy Skin Disease, 53–62. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-92411-3_13.
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Williams, H. C. "Epidemiology of Skin Disease." In Rook's Textbook of Dermatology, 1–21. Oxford, UK: Wiley-Blackwell, 2010. http://dx.doi.org/10.1002/9781444317633.ch6.
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Susitaival, Päivikki. "Questionnaire Design in Skin Disease Epidemiology." In Cutaneous Biometrics, 43–53. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-1199-1_4.
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Susitaival, Päivikki. "Questionnaire Methods in Occupational Skin Disease Epidemiology." In Kanerva’s Occupational Dermatology, 1–6. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-40221-5_81-2.
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Susitaival, Päivikki. "Questionnaire Methods in Occupational Skin Disease Epidemiology." In Kanerva's Occupational Dermatology, 915–17. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-02035-3_81.
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Susitaival, Päivikki. "Questionnaire Methods in Occupational Skin Disease Epidemiology." In Kanerva’s Occupational Dermatology, 1273–77. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-68617-2_81.
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Pijpe, A., K. L. M. Gardien, R. E. van Meijeren-Hoogendoorn, E. Middelkoop, and Paul P. M. van Zuijlen. "Scar Symptoms: Pigmentation Disorders." In Textbook on Scar Management, 109–15. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_12.
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AbstractThis chapter provides an overview of the epidemiology, pathophysiology, course, measurement, and potential therapies for pigmentation disorders in scars. Pigmentation problems are a common consequence of deep partial- and full-thickness burns, other skin trauma or disease, and surgical procedures. Both hypopigmentation and hyperpigmentation can cause esthetic and psychological issues, which may influence quality of life. The role of melanocytes and the maturation of pigmentation problems are discussed. To determine the severity of pigmentation problems and for therapeutic evaluation, different subjective and objective methods have been validated. Simple and easy-to-use measurement instruments are available based on spectrophotometric techniques. Also scar assessment scales with subscales for color and pigmentation are convenient and validated methods for quantitative evaluation of skin pigment disorders. Treatment options are discussed and include camouflage therapy, topical treatments, chemical peels, laser therapy, dermatography, dermabrasion, microneedling, skin grafting, cell therapy, and excision. It is advised to first try the conservative options and to dose and monitor the treatment to prevent overshoot and complications.
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Allen, Heidi. "Skin cancer." In Oxford Handbook of Cancer Nursing, edited by Mike Tadman, Dave Roberts, and Mark Foulkes, 445–52. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198701101.003.0034.
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This chapter focuses on the management of skin cancer, exploring both malignant melanoma and non-melanoma skin cancer. The epidemiology of melanoma is covered, and risk factors are described. Management looks at both early-stage and widespread disease, including surgery, adjuvant drug therapy, and radiotherapy. There is further emphasis on recent developments in biological and immunotherapy treatments such as ipilimumab and nivolumab. Non-melanoma skin cancer is discussed, covering risk factors and presentation of these diseases and a summary of their management.
Conference papers on the topic "Skin Diseases, epidemiology"
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Brum, Sara Julia Zorzi de, Eduarda Pilati, Haniel Willen Araújo Souza, Jackson Pagno Lunelli, Raimundo Maurício dos Santos, Sarah Gondim Santos Paulino, Ivana Loraine Lindemann, Renata dos Santos Rabello, and Ana Luísa Casado Brasil Dozza. "Epidemiology of accidental tetanus in Brazil from 2009-2019." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.197.
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Background: Accidental tetanus is an infectious disease caused by acute intoxication from Clostridium tetani’s exotoxin. Manifestations include intermittent tonic spasms due to central nervous system’s hyperexcitability. Objectives: To estimate the lethality rate and describe the epidemiological profile of patients diagnosed with accidental tetanus in Brazil. Design and setting: Ecological descriptive study developed at Federal University of Fronteira Sul, Passo Fundo, Brazil. Methods: The data was obtained from the Notifiable Diseases Information System (SINAN). All cases confirmed in Brazil from 2009 to 2019 were included. Variables sex, skin color, age group, outcome and region of notification were selected. Descriptive statistics were used based on absolute (n) and relative (%) frequencies and the lethality rate was calculated. Results: 2,969 cases were included, with a 34% decrease from 2009 to 2019. The majority were male (85.3%), brown people (51%), age group of 40-59 years (39.9%) and in the northeast region (33.3%). Cure was seen in 52.5% and the lethality rate was 32.3%. Conclusions: Though cases reduced, accidental tetanus still is a public health issue because of its high lethality rate. Immunization, offered by the Brazilian public health system, can prevent it, indicating the necessity to increase immunization rates.
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Karpova, O. A., V. A. Semenikhin, and B. A. Balandovich. "HYGIENIC INFLUENCE OF PRODUCTION FACTORS ON THE EPIDEMIOLOGY OF DERMATOSES IN RAILWAY TRANSPORT WORKERS IN THE CONTEXT OF THE COVID-19 PANDEMIC." In The 16th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2021). FSBSI “IRIOH”, 2021. http://dx.doi.org/10.31089/978-5-6042929-2-1-2021-1-241-245.
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Abstract: Introduction. In the context of the COVID-19 pandemic, it is necessary to look for new approaches to the prevention, diagnosis and treatment of skin diseases in the working population. Study objective. To study the hygienic influence of harmful and dangerous factors of the working environment and the severity of the labor process on the structure of the general dermatological morbidity in railway transport workers who ensure the safety of train traffic in the conditions of the COVID-19 pandemic. Materials and methods. The complex of harmful production factors affecting railway transport workers was studied according to the sanitary and hygienic characteristics of the working conditions of employees of the Altai region of the West Siberian Railway of JSC "Russian Railways". The structure of the general dermatological morbidity was studied according to the statistical coupons of outpatient patients who applied to a dermatovenerologist in the CHUZ " CB "Russian Railways-Medicine" Barnaul for the period 2019-2020. Results. The conducted complex of hygienic, epidemiological and statistical studies showed that the combined impact of chemical, meteorological, physical, biological harmful production factors and the severity of the labor process (class 3.1-3.5) in railway transport workers who ensure the safety of train traffic leads to the development of such production-related skin diseases as contact dermatitis and psoriasis. In the context of the COVID-19 pandemic, skin infections (62.8%) predominate over non-infectious dermatoses in the structure of the total dermatological morbidity. The share of primary morbidity increased to 90.8%. The first rank is occupied by pyoderma (47.5%), the second – allergodermatoses (20.0%), the third – mycoses (11.6%). Conclusion. The COVID-19 pandemic leads to changes in the epidemiological and clinical features of dermatoses in the working population, which must be taken into account in their prevention, diagnosis and treatment.
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Linn Holness, D., Sandy Skotnnicki, Joel DeKoven, and Irena Kudla. "P-390 Using a clinical database to inform prevention of occupational skin disease with a focus on the health care sector." In 28th International Symposium on Epidemiology in Occupational Health (EPICOH 2021). BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/oem-2021-epi.306.
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Grando, Gabriel Fiorio, and Juliano Peixoto Bastos. "EPIDEMIOLOGIC PROFILE OF MEN HOSPITALIZED WITH BREAST CANCER IN BRAZIL." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1033.
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Introduction: Breast cancer is the most common type of cancer among women worldwide and in Brazil, just after nonmelanoma skin cancer. Breast cancer can also occur in men, although being rare, representing 1% of the total number of notifications of the disease. Due the rarity of this pathology, little is known about the etiology of male breast cancer, but some risk factors such as advanced age, hormonal imbalance, and family history have been pointed out. Objectives: This study’s objective was to understand the epidemiologic profile of the men hospitalized due breast cancer in Brazil in the previous five years. Methods: This is a descriptive study of secondary data, which were gathered using the IT Department of the Brazilian Unified Health System, and it corresponds to the cases registered from January 2016 to December 2020. The data of interest were those related to the total number of admissions, age range, ethnicity, mortality rate, average amount spent in each hospitalization. Results: There were 3,501 (100%) admissions in Brazil due to male breast cancer. In the Southeast, there were 1,439 (41.1%) hospital admissions, being this the part of the country with the majority of hospitalized men. Followed by this region are the Northeast (26.7%), the South (18.1%), the Midwest (8.3%) and the North (5.7%). The year showing most notifications was 2019, with 832 hospital admissions (23.7%). The other years under review do not show significant changes in the number of admissions. The predominant age group was between 60 to 69 years (26.5%), followed by 50–59 (21.5%), 70–79 (19.9%) and 40–49 years (13.4%). Regarding ethnicity, white and brown men had similar notifications, 1,326 (37.8%) and 1,248 (35.6%) respectively. The remaining percentage is for not registered (20.1%), blacks (5.0%), yellow (1.4%) and indigenous (0.02%). The mean length of hospital stay for men with breast cancer was 4.3 days, ranging from 3.0 to 5.5 across the regions. The mortality rate was 9.40% in Brazil. Regarding the regions, the Northeast showed the highest mortality rate, 14.50%. The average amount spent on each hospitalization was R$ 1,917.70 (USD 354,74, approximately). Conclusions: In Brazil, the mortality rate of men due to breast cancer is higher than the mortality rate of women with breast cancer, which is 8.44%. Therefore, the prognosis for male and female breast cancer is similar, but the overall survival rates are lower for males due to older age and advanced stage at diagnosis. Patients and health providers should pay attention to the existence of breast cancer in men and its known risks factors. Also, at last, many patients receiving hormonal therapy as a treatment for other diseases (eg., prostate cancer) should be aware of its side effect of the development of breast cancer in men.
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Linn Holness, D., Joel DeKoven, Benjamin DeKoven, and NACDG Members. "RF-405 Occupational skin disease surveillance using a clinical patch test database over time: the results of the North American Contact Dermatitis Group: 2001–2016." In 28th International Symposium on Epidemiology in Occupational Health (EPICOH 2021). BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/oem-2021-epi.368.
Full textReports on the topic "Skin Diseases, epidemiology"
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Matthew, Gray. Data from "Winter is Coming – Temperature Affects Immune Defenses and Susceptibility to Batrachochytrium salamandrivorans". University of Tennessee, Knoxville Libraries, January 2021. http://dx.doi.org/10.7290/t7sallfxxe.
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Environmental temperature is a key factor driving various biological processes, including immune defenses and host-pathogen interactions. Here, we evaluated the effects of environmental temperature on the pathogenicity of the emerging fungus, Batrachochytrium salamandrivorans (Bsal), using controlled laboratory experiments, and measured components of host immune defense to identify regulating mechanisms. We found that adult and juvenile Notophthalmus viridescens died faster due to Bsal chytridiomycosis at 14 ºC than at 6 and 22 ºC. Pathogen replication rates, total available proteins on the skin, and microbiome composition likely drove these relationships. Temperature-dependent skin microbiome composition in our laboratory experiments matched seasonal trends in wild N. viridescens, adding validity to these results. We also found that hydrophobic peptide production after two months post-exposure to Bsal was reduced in infected animals compared to controls, perhaps due to peptide release earlier in infection or impaired granular gland function in diseased animals. Using our temperature-dependent infection results, we performed a geographic analysis that suggested that N. viridescens populations in the northeastern United States and southeastern Canada are at greatest risk for Bsal invasion. Our results indicate that environmental temperature will play a key role in the epidemiology of Bsal and provide evidence that temperature manipulations may be a viable Bsal management strategy.
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Shpigel, Nahum Y., Ynte Schukken, and Ilan Rosenshine. Identification of genes involved in virulence of Escherichia coli mastitis by signature tagged mutagenesis. United States Department of Agriculture, January 2014. http://dx.doi.org/10.32747/2014.7699853.bard.
Full textAbstract:
Mastitis, an inflammatory response of the mammary tissue to invading pathogenic bacteria, is the largest health problem in the dairy industry and is responsible for multibillion dollar economic losses. E. coli are a leading cause of acute mastitis in dairy animals worldwide and certainly in Israel and North America. The species E. coli comprises a highly heterogeneous group of pathogens, some of which are commensal residents of the gut, infecting the mammary gland after contamination of the teat skin from the environment. As compared to other gut microflora, mammary pathogenic E. coli (MPEC) may have undergone evolutionary adaptations that improve their fitness for colonization of the unique and varied environmental niches found within the mammary gland. These niches include competing microbes already present or accompanying the new colonizer, soluble and cellular antimicrobials in milk, and the innate immune response elicited by mammary cells and recruited immune cells. However, to date, no specific virulence factors have been identified in E. coli isolates associated with mastitis. The original overall research objective of this application was to develop a genome-wide, transposon-tagged mutant collection of MPEC strain P4 and to use this technology to identify E. coli genes that are specifically involved in mammary virulence and pathogenicity. In the course of the project we decided to take an alternative genome-wide approach and to use whole genomes bioinformatics analysis. Using genome sequencing and analysis of six MPEC strains, our studies have shown that type VI secretion system (T6SS) gene clusters were present in all these strains. Furthermore, using unbiased screening of MPEC strains for reduced colonization, fitness and virulence in the murine mastitis model, we have identified in MPEC P4-NR a new pathogenicity island (PAI-1) encoding the core components of T6SS and its hallmark effectors Hcp, VgrG and Rhs. Next, we have shown that specific deletions of T6SS genes reduced colonization, fitness and virulence in lactating mouse mammary glands. Our long-term goal is to understand the molecular mechanisms of host-pathogen interactions in the mammary gland and to relate these mechanisms to disease processes and pathogenesis. We have been able to achieve our research objectives to identify E. coli genes that are specifically involved in mammary virulence and pathogenicity. The project elucidated a new basic concept in host pathogen interaction of MPEC, which for the best of our knowledge was never described or investigated before. This research will help us to shed new light on principles behind the infection strategy of MPEC. The new targets now enable prevalence and epidemiology studies of T6SS in field strains of MPEC which might unveil new geographic, management and ecological risk factors. These will contribute to development of new approaches to treat and prevent mastitis by MPEC and perhaps other mammary pathogens. The use of antibiotics in farm animals and specifically to treat mastitis is gradually precluded and thus new treatment and prevention strategies are needed. Effective mastitis vaccines are currently not available, structural components and effectors of T6SS might be new targets for the development of novel vaccines and therapeutics.