Academic literature on the topic 'Skin, diseases, psychosomatic aspects'
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Journal articles on the topic "Skin, diseases, psychosomatic aspects"
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Varzhapetyan, Asmik A., I. Yu Dorozhenok, and K. M. Lomonosov. "VITILIGO AND COMORBID PSYCHOSOMATIC DISORDERS." Russian Journal of Skin and Venereal Diseases 22, no. 1-2 (April 15, 2019): 33–38. http://dx.doi.org/10.17816/dv42934.
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Vitiligo is a chronic idiopathic disease characterized by appearance of depigmented spots and discolored hairs in various parts of the body due to the destruction and reducing the number of melanocytes. Despite the absence of somatogenic appearance psychosomatic aspects of vitiligo are extremely relevant to study in view of high psychosocial significance associated with the pronounced stigmatizing effects. 62 vitiligo patients were examined. Among comorbid psychosomatic disorders there were found out psychogenic manifestations - 25 (40.3%) and nosogenic reactions due to stress effect of the dermatosis - 37 (50.7%): sociophobic - 17, masked hypochondria - 13, overvalued hypochondria of beauty - 7 patients. Psychogenic manifestations with the participation of objectively severe and subjectively significant factors can attribute vitiligo to psychosomatic skin diseases. In the clinical picture of nosogenic disorders, various forms of dissociation between the prevalence of dermatosis and subjective reaction to the cosmetic defect were revealed, which is due to the structure of the personality and somatoperceptive accentuation of the patient. The results can be implemented in dermatological practice, which will significantly optimize the treatment and compliance of patients with vitiligo. Objective: a complex clinical (dermatological, psychopathological) and psychological study of psychosomatic disorders in vitiligo.
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Da Silva, Lucielma Maria. "Alopecia and Emotional Aspects Related to Hair." Brazilian Journal of Hair Health 1, no. 1 (May 8, 2024): bjhh11. http://dx.doi.org/10.62742/2965-7911.2024.1.bjhh11.
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Introduction: Alopecia is a dermatological condition where hair loss occurs suddenly or gradually in one or more areas of the body, most commonly on the scalp. Studies focusing on the psychosocial and emotional aspects highlight the influence of traumatic situations and stress-related events on the progression of diseases, considered as triggering factors for alopecia. In this context, this study is justified by its aim to describe the disorder, outline the research, and address some issues of concern to researchers and professionals. It highlights that so-called psychosomatic diseases, disorders with an emotional origin, can be factors leading to physical problems that may affect hair, skin, and nails. Methodology: This paper aims to describe the approach for making a diagnosis, outline the emotional aspects in response to the disease, and detail the treatments tried and described in the consulted literature. It is a qualitative literature review conducted during November and December 2021, using databases such as Lilac’s, Medline, Pubmed, and Scielo. Results and Conclusion: Many studies suggest examining the role of coping and social support, the latter being seriously affected by changes in the appearance of individuals with alopecia.
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Harth, Wolfgang, and Ulrike Blume-Peytavi. "Psychotrichology: psychosomatic aspects of hair diseases." JDDG: Journal der Deutschen Dermatologischen Gesellschaft 11, no. 2 (November 26, 2012): 125–35. http://dx.doi.org/10.1111/j.1610-0387.2012.08034.x.
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Belugina, Olga. "Psychosomatic aspects of psoriasis and atopic dermatitis." BJPsych Open 7, S1 (June 2021): S7—S8. http://dx.doi.org/10.1192/bjo.2021.80.
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AimsThe aim of this study is to assess the level of alexithymia, coping strategies and stress contribution to illness in patients with psoriasis and atopic dermatitis in order to increase effectiveness of dermatological treatment.Method59 patients with atopic dermatitis, 67 with psoriasis and 65 healthy control group individuals were included in the cross-sectional study. Predominant complains of the patients: itching, widespread rashes and rashes on the open areas of the skin. In 85% patients with skin pathology onset of the disease and relapses were associated with stress, in 15% other factors.“The 20-item Toronto Alexithymia Scale” was used to assess alexithymia. “The Ways of Coping Checklist, Lazarus” was used to assess coping-strategies. “The Holmes and Rage Stress Inventory” was used to assess stress contribution to illness. Significance level: p < 0,05.ResultThe levels of alexithymia (p = 0.002), difficulty identifying feelings subscale (p = 0.02) and externally-oriented thinking subscale (p = 0.002) in patients with skin pathology (especially in those with psoriasis) were higher than in the control group.Patients with skin pathology turned out to be more susceptible to stress factors (p = 0.025) and less often use coping strategy “seeking social support” (p = 0.037).Patients with skin pathology with high levels of alexithymia and difficulty identifying feelings subscale more likely to use maladaptive “escape-avoidance” coping (p = 0.001).Patients with atopic dermatitis who find difficult to describe feelings are more likely to use maladaptive coping “distancing”(p = 0.002).In patients with psoriasis high levels of alexithymia and externally-oriented thinking subscale scores are associated with less common use of the adaptive coping “problem solving”(p = 0.001). Moreover, in patients with psoriasis high levels of difficulty identifying feelings subscale are associated with more common use of maladaptive “escape-avoidance” coping (p = 0.001).ConclusionThe results of the study confirm the need to include psychological assessment and psychotherapy in the treatment plan for patients with psoriasis and atopic dermatitis in order to improve emotional awareness and to develop more adaptive coping-strategies in patients.
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Picardi, Angelo, Paolo Pasquini, Damiano Abeni, Giovanni Fassone, Eva Mazzotti, and Giovanni A. Fava. "Psychosomatic Assessment of Skin Diseases in Clinical Practice." Psychotherapy and Psychosomatics 74, no. 5 (2005): 315–22. http://dx.doi.org/10.1159/000086323.
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Dorozhenok, I. Yu. "Nosogenic psychosomatic disorders in patients with skin diseases." Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 123, no. 4 (2023): 36. http://dx.doi.org/10.17116/jnevro202312304236.
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Moser, Gabriele. "Psychosomatik der Darmerkrankungen/ Psychosomatic aspects of bowel diseases." Zeitschrift für Psychosomatische Medizin und Psychotherapie 52, no. 2 (July 2006): 112–26. http://dx.doi.org/10.13109/zptm.2006.52.2.112.
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Dorozhenok, I. Yu, E. S. Snarskaya, and М. Mikhailova. "Psychosomatic disorders associated with pruritus in patients with lichen planus (review)." Russian Journal of Skin and Venereal Diseases 23, no. 1 (August 2, 2020): 42–49. http://dx.doi.org/10.17816/dv2020142-49.
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This review examines the psychosomatic aspects of pruritus in dermatological practice, as well as chronic dermatoses associated with pruritus of psychosomatic disorders in a lichen planus model. As the leading nosogenic factor, skin itching is involved in the development of psychogenic, neurotic, and depressive disorders. Notably, psychosomatic disorders associated with itching form various comorbidities with phenotypic manifestations of lichen planus. The introduction of an integrated multidisciplinary approach into the clinical practice, with the inclusion of psychocorrectional techniques in basic dermatological treatment, can help to optimize the course of skin disease. The modern domestic and foreign sources of literature were reviewed.
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Shafaei, Hassan, Elena G. Ichitovkina, and Sergey V. Zhernov. "Psychosocial aspects for effectiveness of complex rehabilitation treatment among patients with psychosomatic diseases." Psychological-Pedagogical Journal GAUDEAMUS, no. 1 (2023): 55–66. http://dx.doi.org/10.20310/1810-231x-2023-22-1-55-66.
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In the conditions of social and economic instability, negative impact of the environment, modern society is experiencing difficulties in adapting to enormous psychological stresses. The constant increase in the intensity of work and the flow of negative information provokes the emergence of psychosomatic diseases in individuals and social groups of the population. The percentage of psychosomatic disorders in the structure of general morbidity has a stable upward trend, they are characterized by a chronic course and duration, and their prevention and treatment are not effective enough today. The development of the principles of adequate and timely prevention of psychosomatic diseases and the effective selection of methods of social and psychological rehabilitation is the most important task of preventive psychology. To assess the social and psychological effect of the use of Tai Chi Qigong rehabilitation exercises in the complex treatment of psychosomatic diseases we conduct a continuous clinical and anamnestic study and psychological testing of 31 people receiving treatment in hospital due to the presence of psychosomatic disorders. It is shown that the use of the technique of rehabilitation exercises contributes to effectiveness of functional disorders restoration and positive thinking. It is proposed to consider the possibility of conducting interdisciplinary scientific research aimed at in-depth study of the influence of the Tai Chi Qigong technique on a wider range of clinical and laboratory symptoms of psychosomatic diseases, which will contribute to improving the quality of psychological и medical care for this category of patients, as well as improve their quality of life and social activity.
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Dorozhenok, Igor Yu, and Ekaterina V. Ilina. "Psychosomatic aspects of psoriasis (review)." Russian Journal of Skin and Venereal Diseases 24, no. 3 (June 15, 2021): 251–62. http://dx.doi.org/10.17816/dv71927.
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The review reflects the increased scientific interest in the psychosomatic aspects of psoriasis in the world literature in recent years. The studied material of the articles is structured according to the principles of the modern clinical psychosomatic approach. The introduction substantiates the relevance of studying this topic. The article considers the stress manifestations/examinations of psoriasis under the influence of psychosocial acute and chronic stress, including under the action of the COVID-19 pandemic; the quality of life and stigmatization of patients with psoriasis. The driving factors leading to the formation of nosogenic psychosomatic disorders are identified: common disfiguring rashes, itching, recurrent course, the threat of disability, social restrictions, constitutional premorbid features of patients. The description of comorbid mental disorders of the anxiety and affective range with a discussion of suicidal risk is presented. A separate section of the review is devoted to itching, as one of the most discussed aspects of psoriasis in the modern literature. Different points of view on the psycho-biological structure of itching in psoriasis are presented. Various factors related to the intensity, objective and subjective perception of itching are considered. Among them are the clinical form and severity of psoriasis, the localization and prevalence of rashes, gender, age, level of education, marital status of patients, concomitant somatic and mental diseases.
Dissertations / Theses on the topic "Skin, diseases, psychosomatic aspects"
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Lonne-Rahm, Sol-Britt. "Etiological and clinical aspects of skin sensitivity /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-746-0.
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Broderick, Daniel J. "Mitral valve prolapse syndrome : a proposed treatment through respiratory rebalancing." Virtual Press, 1996. http://liblink.bsu.edu/uhtbin/catkey/1027110.
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Mitral Valve Prolapse Syndrome (MVPS) is a benign psychosomatic cardiac condition that can severely impair one's quality of life. Symptoms targeted in this study include, atypical chest pain, palpitations, anxiety, panic, and shortness of breath.This study was undertaken to examine the effects of a diaphragmatic breathing intervention on the symptoms and underlying mechanism of dysautonomia in a small group of symptomatic females with MVPS. The intervention was based on both yoga theory and cardiorespiratory empirical studies.Seven of eight participant's completed the nine week study using a single subject multiple baseline design across subjects. Participant's began a respiratory retraining intervention, in a weekly staggered pair start, after the first week of baseline measurement. Respiratory training consisted of a four week training in diaphragmatic breathing with home practice three times a day.Autonomic, behavioral, and cognitive systems were assessed. Dependent measures included State and Trait Anxiety, Anxiety Sensitivity, a Symptom Checklist, and Respiratory Sinus Arrhythmia (RSA). RSA is a current noninvasive measure of parasympathetic tone. Data on thoracic and abdominal respiratory predominance, respiration rate, diet, exercise, and adherence were also gathered.Data were analyzed via visual inspection of trends and phase average changes. Treatment effect sizes were calculated for standardized measures to indicate the meaningfulness of change.Two of the seven participants demonstrated a decrease in total symptom frequencies over the course of intervention. One participant demonstrated a weekly progression of lowered state anxiety scores from baseline through intervention. In terms of phase averages, three participants showed a lowering of state anxiety. All seven participants demonstrated lowered trait anxiety scores from pre to post intervention. Two of the seven participants demonstrated a meaningful pre to post intervention decrease in anxiety sensitivity. Respiratory training was effective in stabilizing abdominal respiration. Results regarding vagal tone could not be determined due to unreliable ECG data.In general, results were poor with several inconsistencies. Adherence rates were low and it did not appear that a therapeutic level of change in respiration rate was achieved. Controlling respiration rate may be a critical factor in the therapeutic effectiveness of respiratory retraining interventions.Department of Counseling Psychology and Guidance Services
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Lai, Josanna Yuk-Lin. "Is keeping in or letting out anger good for your heart?" Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/30099.
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Given the presumed importance of cardiovascular reactivity and the role of anger in the development of hypertension and coronary heart disease, this study is the first to jointly examine three related areas (i.e. gender effects, anger direction preference, and opportunity/no opportunity to aggress following an anger Inducing situation). The present study tested the following hypotheses: a) that cardiovascular reactivity would vary as a function of subjects' gender and direction preference; b) that the rate of cardiovascular recovery would vary as a function of anger direction preference and opportunity/no opportunity to aggress; c) that the subjective feelings of anger after harassment would vary as a function of gender, anger direction preference, and opportunity/no opportunity to aggress; and d) that the evaluation of experimenter's competency and performance would vary as a function of anger preference. 56 females and 49 males executed a math task while being harassed for "poor performance". Next, they were randomly assigned to either write a negative evaluation of the frustrator or to copy a neutral paragraph and then to circle some letters in another paragraph. Heart rate and blood pressure were measured intermittently throughout. Subjects' preferred mode of anger expression (i.e. anger-in versus anger-out) had been previously assessed and cross validated by self as well as peer evaluations. Results indicated that gender was a better predictor than anger direction preference for cardiovascular reactivity to harassment. Complex patterns of recovery were detected with Intriguing sex differences. Results on male diastolic recovery were consistent with a matching hypothesis of anger direction preference but only for anger-out males. In addition, subjective anger for males was related to opportunity/no opportunity conditions, whereas females did not show such a relationship. Female anger-ln's showed quicker systolic recovery than anger-out's. Lastly, the evaluation of experimenter's competency and performance did not vary as a function of anger preference. Therapeutic implications of the findings within the context of anger control as well as trends for future research are discussed.Arts, Faculty of
Psychology, Department of
Graduate
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Meyer, Joana Ladeira [UNESP]. "Avaliação do padrão de metilação de regiões promotoras dos genes ESR1, ESR2 e PGR na endometriose profunda intestinal." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/92428.
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A endometriose é uma doença inflamatória estrógeno-dependente que afeta de 5 a 10% das mulheres em idade reprodutiva. É caracterizada pela presença de tecido endometrial fora da cavidade uterina e está associada à dismenorreia, dor pélvica e infertilidade. Os níveis de expressão dos receptores nucleares SF1 (fator esteroidogênico 1), estrógeno e progesterona estão alterados no tecido endometriótico comparado ao endométrio normal. Estudos prévios relataram que os genes codificadores dos receptores dos hormônios esteróides ESR1 (receptor de estrógeno 1), ESR2 (receptor de estrógeno 2) e progesterona (PGR) apresentam promotores alternativos que são modulados epigeneticamente por alterações na metilação do DNA, que ocorre preferencialmente nas ilhas CpG presentes nestas regiões. Em células endometriais normais foi observada uma associação entre a presença de metilação e ausência de expressão dos genes SF1 e ESR2 (receptor de estrógeno â) enquanto a perda da metilação foi correlacionada com níveis aumentados de expressão gênica na endometriose peritoneal e ovariana. Com base nestas evidências, o presente trabalho investigou o padrão de metilação dos genes PGR (promotores A e B), ESR1 (promotores A e B) e uma região intragênica ao ESR2. O promotor B do gene PGR e a ilha CpG localizada na 5’UTR do gene ESR2 foram avaliadas em 44 amostras de endometriose profunda intestinal pela técnica de MSP (Methylation-Specific Polymerase Chain Reaction). Em sete destas, também foi possível a investigação na amostra pareada de endométrio eutópico. O padrão de metilação dos promotores A e B do gene ESR1 e o promotor A do gene PGR...
Endometriosis is an estrogen-dependent inflammatory disease which affects 5 to 10% of women of reproductive age. This disease is characterized by the presence of endometrial tissue outside the uterine cavity and is associated with dysmenorrhea, pelvic pain, and infertility. Abnormal expression levels of SF1 (steroidogenic factor 1), estrogen and progesterone nuclear receptors were detected in the endometriotic tissue compared to the normal endometrium. Previous studies have reported that genes encoding the steroid hormone receptors ESR1 (estrogen receptor 1), ESR2 (estrogen receptor 2) and progesterone (PGR) are characterized by alternative promoters epigenetically regulated by DNA methylation at CpG islands co-localized in these regions. In normal endometrial cells, it was observed an association between DNA methylation and absence of expression of the genes SF1 and ESR2 (estrogen receptor â), while loss of DNA methylation was correlated with increased expression levels of these genes in peritoneal and ovarian endometriosis. Based on these findings, this study investigated the methylation pattern of the PGR (promoters A and B), ESR1 (promoters A and B) genes and an intragenic region of the gene ESR2. The promoter B of PGR gene and the CpG island mapped at 5 'UTR of the ESR2 gene were evaluated in 44 samples of intestinal deep endometriosis by MSP (methylation-specific polymerase chain reaction). In seven cases, paired samples of eutopic endometrium from the same patients were also evaluated, the methylation patterns of the ESR1 gene (promoters A and B) and the promoter region A of the PGR gene were investigated in 37 samples of endometriosis. The MSP method is based on the DNA modification by sodium bisulfite, which converts unmethylated cytosines to uracil. Subsequently, the target region... (Complete abstract click electronic access below)
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Burgess, Carolyn E. "Sexual Function in Women Following Treatment for Cervical Dysplasia and Microinvasive Cervical Carcinoma." Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc331592/.
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One hundred women aged 20 to 50 were asked to compare their sexual experience before diagnosis and following treatment for benign and malignant cervical disease. The subjects were divided into five groups: three groups had definite cervical intraepithelial neoplasia (CIN), (Class II or III). Two groups were treated with cryotherapy, and one with hysterectomy. One group had a provisional diagnosis of CIN I, but received no treatment. Subjects in the last group had microinvasive cervical carcinoma and were also treated with hysterectomy. All subjects had ovarian function; all were sexually active at the time of treatment. They were interviewed at least six months post-cryotherapy and 15 months post-hysterectomy. All subjects completed a variant version of the Derogatis Sexual Function Inventory (DSFI).
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Meyer, Joana Ladeira. "Avaliação do padrão de metilação de regiões promotoras dos genes ESR1, ESR2 e PGR na endometriose profunda intestinal /." Botucatu : [s.n.], 2011. http://hdl.handle.net/11449/92428.
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Orientador: Cláudia Aparecida RainhoBanca: Roberta Guembarovisk
Banca: Celia Regina Nogueira
Resumo: A endometriose é uma doença inflamatória estrógeno-dependente que afeta de 5 a 10% das mulheres em idade reprodutiva. É caracterizada pela presença de tecido endometrial fora da cavidade uterina e está associada à dismenorreia, dor pélvica e infertilidade. Os níveis de expressão dos receptores nucleares SF1 (fator esteroidogênico 1), estrógeno e progesterona estão alterados no tecido endometriótico comparado ao endométrio normal. Estudos prévios relataram que os genes codificadores dos receptores dos hormônios esteróides ESR1 (receptor de estrógeno 1), ESR2 (receptor de estrógeno 2) e progesterona (PGR) apresentam promotores alternativos que são modulados epigeneticamente por alterações na metilação do DNA, que ocorre preferencialmente nas ilhas CpG presentes nestas regiões. Em células endometriais normais foi observada uma associação entre a presença de metilação e ausência de expressão dos genes SF1 e ESR2 (receptor de estrógeno â) enquanto a perda da metilação foi correlacionada com níveis aumentados de expressão gênica na endometriose peritoneal e ovariana. Com base nestas evidências, o presente trabalho investigou o padrão de metilação dos genes PGR (promotores A e B), ESR1 (promotores A e B) e uma região intragênica ao ESR2. O promotor B do gene PGR e a ilha CpG localizada na 5'UTR do gene ESR2 foram avaliadas em 44 amostras de endometriose profunda intestinal pela técnica de MSP (Methylation-Specific Polymerase Chain Reaction). Em sete destas, também foi possível a investigação na amostra pareada de endométrio eutópico. O padrão de metilação dos promotores A e B do gene ESR1 e o promotor A do gene PGR... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Endometriosis is an estrogen-dependent inflammatory disease which affects 5 to 10% of women of reproductive age. This disease is characterized by the presence of endometrial tissue outside the uterine cavity and is associated with dysmenorrhea, pelvic pain, and infertility. Abnormal expression levels of SF1 (steroidogenic factor 1), estrogen and progesterone nuclear receptors were detected in the endometriotic tissue compared to the normal endometrium. Previous studies have reported that genes encoding the steroid hormone receptors ESR1 (estrogen receptor 1), ESR2 (estrogen receptor 2) and progesterone (PGR) are characterized by alternative promoters epigenetically regulated by DNA methylation at CpG islands co-localized in these regions. In normal endometrial cells, it was observed an association between DNA methylation and absence of expression of the genes SF1 and ESR2 (estrogen receptor â), while loss of DNA methylation was correlated with increased expression levels of these genes in peritoneal and ovarian endometriosis. Based on these findings, this study investigated the methylation pattern of the PGR (promoters A and B), ESR1 (promoters A and B) genes and an intragenic region of the gene ESR2. The promoter B of PGR gene and the CpG island mapped at 5 'UTR of the ESR2 gene were evaluated in 44 samples of intestinal deep endometriosis by MSP (methylation-specific polymerase chain reaction). In seven cases, paired samples of eutopic endometrium from the same patients were also evaluated, the methylation patterns of the ESR1 gene (promoters A and B) and the promoter region A of the PGR gene were investigated in 37 samples of endometriosis. The MSP method is based on the DNA modification by sodium bisulfite, which converts unmethylated cytosines to uracil. Subsequently, the target region... (Complete abstract click electronic access below)
Mestre
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Eyjolfsdottir, Gyda 1970. "Psychosocial aspects and functional analysis of symptom-giving pelvic girdle relaxation in Icelandic women." 2004. http://hdl.handle.net/2152/12710.
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"The roles of CCHCR1 protein in skin epidermal cell proliferation." 2009. http://library.cuhk.edu.hk/record=b59646408.b5964640.
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目的:銀屑病是一種慢性炎症性皮膚疾病，特點是角質形成細胞過度增生。角質形成細胞過度增生在銀屑病家族中被證實與位於染色體6p2 1. 3 上的編碼人類白細胞抗原的基因組區有關。通過全基因組掃描，至少確定了10 個銀屑病易感基因位點(PSORS 卜的ORS10) ，而6p21 區的PSORS1 被認為是銀屑病最主要的易感位點，而HLA-C， CCHCRl (coiled coil alpha-helixrod homolog) 和CDSN(corneodesmosin) 是該位點上的重要的侯選基因。然而，這三個基因之間的連鎖不平衡很難將他們的個體效應分開。我們的目標是研究CCHCCRl 基因以及它的相關蛋白在皮膚上皮細胞增生過程中的作用。方法:本研究應用免疫螢光技術'免疫印跡分析和即時反轉錄聚合臨鏈反應 (Real Time RT-PCR) 三種方法比較CCHCRl 基因在銀屑病人的皮損區與正常人的皮膚細胞的表達。其次比較了CCHCRl 蛋白在喜樹鹼(拓撲異構酪I 抑制劑/凋亡誘導劑)的作用下在三種細胞(永生化的人皮膚角質形成細胞-HaCaT '人直結腸癌細胞-HT29 和人子宮頸癌細胞- HeLa) 內的表達。最後，我們應用了皮膚器官樣培養物( OTC) 研究HaCaT 細胞於皮膚角質化過程中CCHCRl 蛋白的表達。
結果:✹HCR1 蛋白在正常皮膚和銀屑病人皮損皮膚表達模式不同，銀屑病人皮損皮膚有五種CCHCR1 蛋白染色模式，而正常人皮膚只有兩種染色模式。免疫印跡分析顯示CCHCR1 蛋白在正常皮膚含量較銀屑病人高。免役螢光顯微技術顯示角蛋白17 (K17) ，一種細胞增生的標誌性蛋白，只表達在正常皮膚基底層的角質細胞中，而在銀屑病人皮膚， K17 從基底層到顆粒層都有顯著表達，並且和CCHCR1 蛋白表達區域相同。這種現象也存在於OTC 發育過程中所有角質細胞中，而CCHCR1 蛋白表達隨OTC 的培養時間從10 天到21 天呈上升趨勢，說明CCHCR1 蛋白與細胞增殖有一定的關係。當細胞生長在培養血表面形成細胞與細胞接合全面的細胞層時， CCHCR1 的信使核糖核酸水平大幅升高，顯示CCHCR1 的信使核糖核酸表達當細胞生長速度呈負相關。CCHCR1 的信使核糖核酸水平在同步化的HaCaT 細胞G2/M 期輕度升高，而蛋白水平在G1 期達到最高。在G2/M 期，高爾基體出現崩解，而CCHCR1 蛋白和其他高爾基蛋白一樣分散到胞漿。這種現象同樣地出現在經2 州喜樹鹼刺激48小時的HeLa 和HaCaT 細胞內，免疫細胞化學染色顯示CCHCR1 和golgin-97 分散到胞漿。CCHCR1 信使核糖核酸水平在HeLa 和HaCaT 細胞都升高，而蛋白在HaCaT 細胞明顯上調。這說明CCHCR1 蛋白量的上調和細胞生長停滯有關。應用siRNA 或shRNA 抑制CCHCR1 蛋白表達後， golgin-97 分散到胞漿，但是HeLa細胞可以繼續增殖。這說明CCHCR1 蛋白可能有助於維持高爾基複合體的完整，喜樹鹼對細胞生長的抑制作用可能與CCHCR1 蛋白的上調相關。
結論: CCHCR1 蛋白在正常皮膚表皮細胞和銀屑病人皮損區細胞胞漿內都有表達，但是正常皮膚表達較銀屑病人高，在OTC 增生後期和細胞生長緩慢或停滯期也明顯升高，說明CCHCRl 基因的上調可能抑制細胞的增生。經喜樹鹼刺激後，細胞生長受到抑制，細胞停滯在Gl 期並誘導細胞凋亡， CCHCRl 的信使核糖核酸和蛋白都上調，表明CCHCRl 與細胞的增生抑制有關。同時，它的下調也造成高爾基複合體的崩解，說明CCHCRl 蛋白可以維持高爾基複合體的結構完整性。因此， CCHCRl 不僅可以保持高爾基複合體的完整而且和細胞的增生有關。另一方面，大量證據表明長期性的高血糖會導致胰島 細胞功能紊亂。鑒於此，揭示胰島功能調節的潛在機理并闡明胰島功能与高血糖症之間的關係變得尤為重要。
Aim: Psoriasis is one of the common chronic inflammatory skin disorders characterized by keratinocyte hyperproliferation, T lymphocyte-mediated inflammation, and abnormal differentiation. Genome-wide scans have revealed that at least ten different susceptibility loci, PSORS1-PSORS10, were linked to psoriasis, among which PSORS 1 on chromosome 6p21.3 was unambiguously associated with families with psoriasis. Three strongly psoriasis-associated susceptibility alleles have been identified in PSORS1, namely HLA-C, CCHCR1 (coiled-coil alpha-helical rod protein 1 ), and CDSN ( comeodesmosin); their strong linkage disequilibrium, however, makes it very difficult to distinguish their individual genetic effects. Among them, we were interested in the CCHCR1 gene, and its possible roles with associated proteins in the process of skin epidermal cell proliferation were studied in this thesis.
Methods: The cellular expressiOn of CCHCR1 protein in the epidermis was compared between human skins from healthy donors and psoriasis patients by immunofluorescence microscopy and immunoblotting analysis. Its intracellular expression was investigated in cultured human immortalized skin keratinocyte cell line (HaCaT), human colorectal cancer cell line (HT29) and human cervical carcinoma HeLa cell line, as well as in the skin keratinocyte-fibroblast organotypic culture (OTC). The responses of these cells to camptothecin (CPT), a topoisomerase I inhibitor, were compared in HaCaT cells, HT29 cells and HeLa cells. In cell experiments, CCHCR1 expression was studied by immunofluorescence microscopy, immunoblotting analysis, and real-time reverse transcriptase-polymerase chain reaction (real-time RT-PCR).
Results: The immunofluorescence staining patterns for CCHCR1 protein were different between normal and psoriasis skin biopsies. There were at least five patterns (Patterns I, III-VI) in psoriatic skins, but only two (Patterns I and II) in the normal skin, implicating that the expression of CCHCR1 protein was changed in psoriasis. Besides the different cellular location of CCHCR1 protein in normal and psoriasis skins, a higher level of CCHCR1 expression was measured in normal skin than that in psoriatic skin by immunoblotting analysis, and immunofluorescence microscopy further revealed a co-localization of CCHCR1 protein with keratin 17 (K17), a proliferation marker protein and also putative autoantigen for psoriasis, to basal keratinocytes of normal skins, and extended further fro m the basal to granular keratinocytes in the epidermis of psoriasis patients, suggesting a close association of CCHCR1 protein to cell proliferation. During epidermal development in OTC, the CCHCR1 protein was expressed in all keratinocyte layers in a time-dependent manner from day 1 0 to day 21, reaching a maximal level at day 21 when cell proliferation decreased and differentiation to the corneum became active. Furthermore, immunofluorescence for K17 remained co-localized to CCHCR1-positive cells in OTC from day 10 to day 14, but the level of K17 was very weak in the keratinocytes of suprabasallayers on day 21. In HaCaT cell culture, CCHCR1 transcription level at 100% confluence was 25 folds higher than that in subconfluence. Taken all these results together, the up-regulation of CCHCR1 was closely related to cell growth inhibition and differentiation. Immunofluorescence microscopy revealed a co-localization of CCHCR1 protein with a Golgi marker protein, golgin-97, in the compact Golgi complex at the juxtanuclear region of HaCaT cells and HeLa cells. CCHCR1 gene transcribed in all phases of the cell cycle, but was slightly higher in the G2/M phase of synchronous HaCaT cells, and its translation reached its maximal level in the G 1 phase. In the G2/M phase, CCHCR1 protein was dispersed in the cytoplasm like the golgin. Such dispersal was also observed in HaCaT cells and HeLa cells treated with CPT for 24 h and 48 h, respectively. CCHCR1 expression increased in both transcriptional and translational levels as well as apoptotic changes following growth arrest in both HeLa cells and HaCaT cells. Depletion of the CCHCR1 protein by means of siRNAor shRNA-mediated knockdown induced HeLa cells proliferation, cell elongation and disassembly of the Golgi complex.
Conclusion: CCHCR1 protein was expressed in the cytoplasm of epidermal keratinocytes of both normal and psoriasis skins, with a higher level detected in the normal skins. It was also found especially abundant in the keratinocytes of skin organotypic cultures during their transition from proliferation to differentiation. CCHCR1 gene transcription was increased obviously in cultured HaCaT cells at confluence. CCHCR1 was also up-regulated at both transcriptional and translational levels in response to the antiproliferative drug, camptothecin, in HaCaT cell experiments, and was accompanied by G 1 arrest and subsequent apoptosis. When CCHCR1 was knockdowned in HeLa cells, the Golgi complex disassembled, implicating a role of CCHCRl protein in the maintenance of Golgi integrity and in the control of cell proliferation.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Wang, Lijun.
Thesis (Ph.D.)--Chinese University of Hong Kong, 2009.
Includes bibliographical references (leaves 107-133).
Abstracts also in Chinese.
Abstract --- p.i
Acknowledgements --- p.viii
List of Abbreviation --- p.ix
Chapter Chapter 1 --- General Introduction --- p.1
Chapter 1.1 --- Psoriasis --- p.1
Chapter 1.2 --- Skin --- p.9
Chapter 1.3 --- An In Vitro Model for Human Skin Equivalent --- p.10
Chapter 1.4 --- Aim of Study --- p.12
Chapter Chapter2 --- Expression of CCHCRl Protein in Psoriasis skin --- p.13
Chapter 2.1 --- Background of Skin and Psoriasis --- p.13
Chapter 2.2 --- Materials and Methods --- p.18
Chapter 2.3 --- Results --- p.21
Chapter 2.4 --- Discussion and Conclusion --- p.25
Chapter Chapter3 --- Expression of CCHCRl Protein in Skin Organotypic Culture --- p.37
Chapter 3.1 --- Background about Skin Organotypic Culture --- p.37
Chapter 3.2 --- Materials and Methods --- p.41
Chapter 3.3 --- Results --- p.45
Chapter 3.4 --- Discussion and Conclusion --- p.49
Chapter Chapter4 --- Expression of CCHCRl Protein in HaCaT Cells Treated with Camptothecin --- p.60
Chapter 4.1 --- Background --- p.60
Chapter 4.2 --- Materials and Methods --- p.61
Chapter 4.3 --- Results --- p.68
Chapter 4.4 --- Discussion and Conclusion --- p.73
Chapter Chapter 5 --- General Discussion --- p.95
References --- p.107
Publications --- p.172
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"Work-related stress and cardiovascular risk factors in Chinese." 2004. http://library.cuhk.edu.hk/record=b6073711.
Full textAbstract:
Xu Liying."April 2004."
Thesis (Ph.D.)--Chinese University of Hong Kong, 2004.
Includes bibliographical references (p. 159-175)
Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Electronic reproduction. Ann Arbor, MI : ProQuest Information and Learning Company, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Mode of access: World Wide Web.
Abstracts in English and Chinese.
10
Berntson, Jessica. "Depressive Symptom Severity, Stressful Life Events, and Subclinical Atherosclerosis in African American Adults." Thesis, 2015. http://hdl.handle.net/1805/8476.
Full textAbstract:
Indiana University-Purdue University Indianapolis (IUPUI)Prospective epidemiologic evidence indicates that both stressful life events (SLEs) and depression are associated with an increased risk of subclinical atherosclerosis and cardiovascular disease (CVD) events. Even though stressful life events (SLEs) and depression co-occur and may act together to influence cardiovascular disease (CVD) risk, these psychosocial factors have been mainly examined in isolation. For instance, depression may moderate the relationship between SLEs and CVD outcomes. I hypothesized that depressive symptoms would potentiate the deleterious effect of SLEs on subclinical atherosclerosis. This hypothesis is plausible, given that depressed adults exhibit exaggerated and prolonged sympathetic nervous system, hypothalamic-pituitary-adrenal (HPA) axis, and inflammatory responses to stress, which in turn could promote atherosclerosis. As compared to their nondepressed counterparts, depressed individuals may also be more likely to engage in maladaptive methods to cope with SLEs (e.g., increased tobacco use, alcohol use, and consumption of low-nutrient, energy dense foods), which could also promote atherosclerosis. I examined cross-sectional data from 274 to 279 (depending on the outcome measure) older, African American adults (mean age = 66 years, 67% female) with no evidence of clinical CVD or dementia who participated in the St. Louis African American Health-Heart study (2009–2011). Number of SLEs was assessed using the Life Events Calendar, a structured interview. From this interview, a continuous SLEs variable was computed (number of adult SLEs: 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11+). Severity of depression symptoms was measured using the 17-item Hamilton Rating Scale for Depression (HAM-D). Two measures of subclinical atherosclerosis were obtained: carotid intima-media thickness (CIMT; assessed by ultrasonography) and coronary artery calcification (CAC; assessed by multi-detector computerized tomography). I conducted linear (CIMT) and logistic (CAC) regression models, first adjusted for demographics (age, sex, education) and then fully-adjusted (demographics; mean arterial pressure; low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C); hemoglobin A1c; BMI; tobacco use; diabetes diagnosis; and use of antihypertensitve, lipid lowering, antidiabetic, and antidepressant medications). No main effects of SLEs or HAM-D were found for CIMT or CAC. There were also no SLEs by HAM-D interactions for CIMT or CAC. Because the current results are largely inconsistent with prior literature and there is a paucity of studies utilizing African American samples, future research is needed to examine the independent and interactive associations of SLEs and depressive symptoms with measures of subclinical atherosclerosis. If the present results are replicated, it may suggest that SLEs, depressive symptoms, and their interactive effect are not cardiotoxic among African American adults.
Books on the topic "Skin, diseases, psychosomatic aspects"
1
Grossbart, Ted A. Skin deep: A mind/body program for healthy skin. New York: W. Morrow, 1986.
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2
Grossbart, Ted A. Skin deep: A mind/body program for healthy skin. Santa Fe, N.M: Health Press, 1992.
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3
França, Katlein, and Mohammad Jafferany. Geriatric psychodermatology: Psychocutaneous disorders in the elderly. Hauppauge], New York: Nova Biomedical, 2015.
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4
M, Koo John Y., and Lee Chai Sue, eds. Psychocutaneous medicine. New York: Marcel Dekker, 2003.
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Maguire, Anne. Skin disease: A message from the soul : a treatise from a Jungian perspective of psychosomatic dermatology. London: Free Association Books, 2004.
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1975-, Walker Carl, and Papadopoulos Linda, eds. Psychodermatology. Cambridge: Cambridge University Press, 2005.
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Alain, Claudy, Euvrard Sylvie, and Kanitakis Jean, eds. Skin diseases after organ transplantation. Montrouge: Eurotext, 1998.
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Rey, Fernando Luis González. Personalidad, salud y modo de vida. Caracas: Fondo Editorial de Humanidades y Educación, Universidad Central de Venezuela, 1992.
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D, Wuepper Kirk, Gedde-Dahl Tobias 1934-, and European Society for Dermatological Research Clinically Oriented International Symposium (1986 : Oslo, Norway), eds. Biology of heritable skin diseases. Basel: Karger, 1987.
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E, Tur, ed. Environmental factors in skin diseases. Karger: Basel ; New York, 2007.
Find full textBook chapters on the topic "Skin, diseases, psychosomatic aspects"
1
Wolman, Benjamin B. "Skin Diseases." In Psychosomatic Disorders, 145–55. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5520-5_16.
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Gupta, Madhulika A. "Aging Skin: Some Psychosomatic Aspects." In Textbook of Aging Skin, 959–69. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-89656-2_90.
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Gupta, Madhulika A. "Aging Skin: Some Psychosomatic Aspects." In Textbook of Aging Skin, 1657–74. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-47398-6_90.
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Gupta, Madhulika A. "Aging Skin: Some Psychosomatic Aspects." In Textbook of Aging Skin, 1–19. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27814-3_90-2.
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McDougall, A. C. "Leprosy: Clinical Aspects." In Mycobacterial Skin Diseases, 119–36. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-2227-3_5.
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Tomecki, K. J. "Environmental (Atypical) Mycobacteria: Clinical Aspects." In Mycobacterial Skin Diseases, 105–17. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-2227-3_4.
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Harahap, M. "Tuberculosis of the Skin: Clinical Aspects." In Mycobacterial Skin Diseases, 79–104. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-2227-3_3.
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Convit, J., and M. I. Ulrich. "Leprosy: Bacterial, Pathological, Immunological and Immunopathological Aspects." In Mycobacterial Skin Diseases, 33–78. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-2227-3_2.
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Grange, J. M. "Tuberculosis and Environmental (Atypical) Mycobacterioses: Bacterial Pathological and Immunological Aspects." In Mycobacterial Skin Diseases, 1–32. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-2227-3_1.
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Garg, Suruchi, Anuva Bansal, and Manjot Kaur Marwah. "Breast Augmentation: Cutaneous Aspects and Complications." In Skin Diseases in Females, 549–86. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-6065-8_26.
Full textConference papers on the topic "Skin, diseases, psychosomatic aspects"
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Silva, CA, MJ Quartilho, JA Da Silva, A. Malcata, and A. Porto. "SAT0143 Psychosomatic aspects of fibromyalgia versus rheumatoid arthritis." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.602.
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Semak, A. N., E. G. Busko, and V. A. Stelmakh. "MEDICAL-ECOLOGICAL AND CYTOGENETIC ASSESSMENT OF INDICATORS OF THE SKIN OF DOMESTIC ANIMALS OF THE CANINE FAMILY (CANIDAE) AND FELIDS (FELIDAE) OF CENTRAL BELARUS." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2021. http://dx.doi.org/10.46646/sakh-2021-2-107-110.
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The study of the genesis of domestic animals in zoogeographic, phylogenetic and cytogenetic aspects allowed us to identify patterns of occurrence and development of various diseases and to predict their dynamics in connection with changes in the complex conditions of their habitat. It was found that among the examined group of dogs in 80,3% of cases were benign neoplasms, in 19,7% of cases the possibility of the occurrence and development of malignant neoplasms was diagnosed. Malignant neoplasms of the skin among the examined cats are detected more often and make up 63,0%, benign - 37,0%, respectively.
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Latorre Sánchez, Consuelo, Juan Antonio Solves, Joaquín Sanchiz Navarro, Ricardo Bayona Salvador, Jose Laparra, Nicolás Palomares, and Jose Solaz. "Methodology Based on 3D Thermal Scanner and AI Integration to Model Thermal Comfort and Ergonomics." In 13th International Conference on Applied Human Factors and Ergonomics (AHFE 2022). AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1001896.
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The current pandemic situation due to the appearance of the coronavirus-2 or SARS-CoV-2 (COVID-19) has increased the demand and familiarization of the population with infrared cameras and their thermal interpretation. Infrared radiation and the technology behind it have become a necessity not only developing new applications for the present but also for the future. In the post-pandemic world, commercial solutions to existing problems are being developed with this technology and with very efficient approaches, reducing costs and complementing many areas.Institute of Biomechanics of Valencia (IBV) is constantly innovating in the field of infrared thermal imaging and its applications in the well-being of people through research, experimentation and user validation. 3D models have been developed merging anthropometric data and thermal information based on scanners, 3D reconstruction and imagen processing. Some of the algorithms for monitoring and reconstruction system are based on a FLIR A35 thermal camera and an INTEL RealSense D455 depth sensor, a low-cost, high-performance sensor.Artificial intelligence techniques applied to images, mainly in visible or RGB datasets, have undergone significant development in recent years, however there is a gap in the application in thermal images. The IBV has compiled a powerful database for years from many users, insulation in clothes, extreme scenarios and different poses and face orientations. Many networks, models and libraries of computer vision, have been explored and some AI techniques (machine and deep learning) have been applied to extract information from those images, although open solutions and networks do not work accurately. The thermal database has been used to retrain these network models and the results have been considerably better.Near real-time, low-cost 3D thermal reconstruction, with embedded AI techniques, has been applied in facemasks evaluation, face recognition, feature and key points extraction, segmentation and development of automatic thermal measure algorithms. From feature extraction and landmark information, aspects such as thermotype, age and sex, have been also determined, or even the effects of the emotions, rotations or artifacts like glasses, facemasks or beards on the identification of the user. IBV has a huge background in this technology and develops new innovative solutions in order to tackle with new challenges, from determining the effect a facemask has, in thermal comfort or breathing rate to helping physician to diagnose certain diseases, such as circulatory, vascular problems and the effect of therapies or cosmetic products. In this way, information on the thermoregulatory behavior of the human body is provided, allowing to relate changes in thermal maps, to certain pathologies or to the effect of a treatment, skin affections, varicose veins or joint injuries.
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Liu, Yanyu, and Hong Chen. "Design of Children's Wearable Moxibustion Instrument Based on Emotional Design Theory." In 14th International Conference on Applied Human Factors and Ergonomics (AHFE 2023). AHFE International, 2023. http://dx.doi.org/10.54941/ahfe1003474.
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Research For children, the excessive use of antibiotics treatment will damage the liver and kidney functions of children, produce drug resistance, affect the health of children, and traditional Chinese medicine has the characteristics of safety, effective and green, among which children moxibustion application has been widely recognized, and the family traditional Chinese medicine health equipment for children is of great significance. Current studies believe that moxibustion plays the function of dredging meridians and regulating the whole body through three aspects: thermal action, near infrared action and biochemical action. But for children, the skin is delicate, and the nerve is weak. The traditional diagnosis and treatment method of moxibustion has some problems, such as heavy smoke smell, difficult time and temperature control, and complex operation. Besides, the quality of electronic moxibustion products on the market is uneven, and children have not been subdivided. The product design of moxibustion instrument that fully considers the physiological and psychological characteristics of users can have good physiotherapy effect and user experience.Research objective: Emotional design has three different dimensions, namely instinct, behavior and reflection, to study the cognitive response and psychological experience of users to products and apply it in design. This paper aims to explore children as the target user group, focus on the specific situation of home care, summarize and analyze the characteristics and needs of users, design a wearable children's home moxibustion instrument that acts on the body surface and acupoints, and create a good physiotherapy experience for users through visual information and interesting design.Research methods: Based on emotional design, this paper discusses the three-level theory method of products and applies it to the design of wearable children's home moxibustion instrument. This paper mainly from three parts: firstly, population analysis and demand exploration. In this study, the characteristics of children groups are summarized by means of observation and user interview, and the internal needs of related users in the home environment are analyzed. The physical and behavioral characteristics of children are fully considered, the psychological and emotional needs of children are studied, and the three-level theory of emotional design is combined to create an interesting physiotherapy experience. Secondly, summarize the application of pediatric moxibustion in daily health care. Summarize the main health needs of users through preliminary investigation, study the multiple diseases in the childhood stage, and sort out the corresponding treatment methods as the theoretical basis of health care. Thirdly, analyze the transmission mode of information and design visualization. In the design, the wearable sensor and communication equipment are investigated and analyzed, and the user's psychology and interaction scenarios were studied through role-playing, service blueprint and other methods, to design the information interface and product interaction mode.Conclusion: This design starts from the collection of users' physiological signals, receives and transforms them into visual information, puts forward health care plan based on children's moxibustion as a theoretical basis, and adjusts users' physical conditions by applying moxibustion patches in line with children's group characteristics to the surface acupoints. Through the three-level theory of emotional design, users are centered, and emotions are taken as the starting point to analyze the group characteristics and potential needs of users, so as to provide design help for providing positive emotional guidance, creating good experience and satisfying deep needs.