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Journal articles on the topic 'Skin irritation study'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Draelos, Zoe, Emil Tanghetti, Linda Stein Gold, et al. "Dermal Irritation, Sensitization, and Safety of Fixed-Dose Triple-Combination Clindamycin Phosphate 1.2%/Benzoyl Peroxide 3.1%/Adapalene 0.15% Gel in Healthy Participants." SKIN The Journal of Cutaneous Medicine 7, no. 4 (2023): s227. http://dx.doi.org/10.25251/skin.7.supp.227.

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Introduction: IDP-126 polymeric mesh gel (clindamycin phosphate 1.2%/benzoyl peroxide [BPO] 3.1%/adapalene 0.15%) is the first triple-combination, fixed-dose topical acne product in development and it addresses major acne pathophysiological processes. IDP-126 demonstrated superior efficacy to vehicle and component dyads, with good safety/tolerability in a phase 2 study of participants with moderate-to-severe acne. The objectives of this study were to assess dermal irritation/sensitization and safety of IDP-126 gel in two phase 1 studies and to compare irritancy of IDP-126 gel and commercially

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Kandárová, Helena, Patrick Hayden, Erin Spiller, Mitch Klausner, Joseph Kubilus, and John Sheasgreen. "In vitro skin irritation test: Increasing the sensitivity of the EpiDerm skin irritation protocol evaluated in the ECVAM skin irritation validation study." Toxicology Letters 172 (October 2007): S81. http://dx.doi.org/10.1016/j.toxlet.2007.05.230.

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Amasa, Wayessa, Dante Santiago, Seblework Mekonen, and Argaw Ambelu. "Are Cosmetics Used in Developing Countries Safe? Use and Dermal Irritation of Body Care Products in Jimma Town, Southwestern Ethiopia." Journal of Toxicology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/204830.

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Background. Rabbit skin model was used to test skin irritation of the most commonly used cosmetic products in Jimma town, southwestern Ethiopia. The most commonly used cosmetics were Dove, Glysolid, College, Top Society, Fair and Lovely, Nivea, Lux, Magic fruit world, Solea, Body talk, Kris, Holly, Victoria, and Sweet Heart.Methods. Intact and abraded rabbit skins were tested for erythema and edema under shade and under sun exposure. Draize Primary Irritation Index (PII) was used to calculate skin irritation of each cosmetic. Cosmetic ingredients were analyzed from the labels.Results and Discu

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H.I., Muhammad Aiman, S. P. Koh, Y. S. Sew, et al. "Anti-inflammatory efficacy and skin irritation study of Cleome gynandra extract: an animal model and pre-clinical evaluation." Food Research 8, Supplementary 3 (2024): 92–103. http://dx.doi.org/10.26656/fr.2017.8(s3).14.

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Cleome gynandra, a kind of medicinal herb which has strong antioxidant properties has been traditionally used for treating various ailments including skin inflammatory diseases. To date, the anti-inflammatory efficacy of C. gynandra based cream has not been reported. The aim of the study was to evaluate the anti-inflammatory activities of C. gynandra leaf extract cream using an in vivo arachidonic acid-induced ear edema in the rat model. The expression of genes related to rat ear inflammation was measured to evaluate the topical anti-inflammatory activity of C. gynandra cream. The toxicity eff

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Rahmi, Dwinna, Retno Yunilawati, Bumiarto Nugroho Jati, et al. "Antiaging and Skin Irritation Potential of Four Main Indonesian Essential Oils." Cosmetics 8, no. 4 (2021): 94. http://dx.doi.org/10.3390/cosmetics8040094.

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Essential oils possess antiaging properties due to their antioxidant activity. This study aims to determine the antiaging activities of four main Indonesian essential oils and their irritation potential on the skin. The spot yeast and in vivo rat skin with UVB exposure methods were used to analyze the antiaging activity of essential oils on aging triggered by endogenous and exogenous factors, respectively. Meanwhile, patch tests and clinical evaluations were used for the skin irritation potential analysis. The antiaging activity results from the endogenous factor showed that the use of clove,

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Bajaj, Himani, Mayank Yadav, Seema B. Chauhan, et al. "ACECLOFENAC LOADED FILM FORMING GELS: IN VIVO STUDY." Indian Drugs 60, no. 06 (2023): 90–93. http://dx.doi.org/10.53879/id.60.06.13865.

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For arthritis, there is need of development of a drug delivery system which permits less frequent dosing by maintaining a close contact with the skin for prolonged time period, thereby improving the patient compliance, especially among elderly. Till date, film forming gels of aceclofenac for arthritis are not available in the market. It is a novel approach which can be used as an alternative to conventional topical and transdermal formulations to treat arthritis. Therefore, HPMC and Eudragit RL 100 based film forming gels of aceclofenac were prepared. On the basis of in vitro potential, the fo

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Rahmi, Dwinna, Retno Yunilawati, Ira Setiawati, et al. "ANTIOXIDANT ACTIVITY, SKIN IRRITAION POTENTIAL AND CHEMICAL COMPOSITION OF CLOVE LEAF OIL FROM WEST JAVA INDONESIA." Jurnal Sains Materi Indonesia 23, no. 1 (2021): 24. http://dx.doi.org/10.17146/jsmi.2021.23.1.6398.

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ANTIOXIDANT ACTIVITY, SKIN IRRITATON POTENTIAL, AND CHEMICAL COMPOSITION OF CLOVE LEAF OIL FROM WEST JAVA INDONESIA. Essential oils with specific chemical compositions have the potential as a source of antioxidants in cosmetics, however, in general, essential oils are not safe because of the potential for skin irritation. This study aims is to perform fractionation to obtain clove oil with a chemical composition that is safe on the skin and does not reduce its antioxidant activity. Fractionation was performed at a temperature of 100 – 285 oC. Chemical composition was determined by Mass Chromat

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8

Ghazali, Ahmad Rohi, Nor Fadilah Rajab, Muhammad Firas Zainuddin, and Nazeha Ahmat. "Assessment of Skin Irritation and Sensitisation Effects by Topical Pterostilbene." Biomedical and Pharmacology Journal 14, no. 4 (2021): 1917–27. http://dx.doi.org/10.13005/bpj/2290.

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Pterostilbene has dermal medicinal benefits such as anti-inflammatory, antioxidative effects and photoprotective properties against UVB radiation. The purpose of this study was to evaluate the dermal toxicity of pterostilbene via skin irritation and sensitisation. A skin irritation test was done according to the Organization Economic Co-operation and Development 404 guideline with the scoring of irritation based on erythema and oedema in 5 albino rabbits were observed up to 14 days. The sensitisation test using the Buehler Test in accordance with the ISO 10993-10 guideline was used to study th

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9

BOTHAM, P. "Outcome of the ECVAM skin irritation validation study." Toxicology 231, no. 2-3 (2007): 98–99. http://dx.doi.org/10.1016/j.tox.2006.11.021.

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10

Bujak, Tomasz, Tomasz Wasilewski, and Zofia Nizioł-Łukaszewska. "Effect of molecular weight of polyvinylpyrrolidone on the skin irritation potential and properties of body wash cosmetics in the coacervate form." Pure and Applied Chemistry 91, no. 9 (2019): 1521–32. http://dx.doi.org/10.1515/pac-2018-0703.

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Abstract Body wash cosmetics are among the most common groups of cosmetics used by consumers. Faced with strong competition in the marketplace, cosmetic manufacturers search for innovative solutions both in terms of product composition and form. An example of an innovative technology which can be used in the production of body wash cosmetics is the process of coacervation which yields a concentrated body wash product. Another important aspect which needs to be considered in the formulation of body wash cosmetics is their safety of use. It is crucial to ensure that such cosmetic products do not

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Retnowati, Dini, Retno Sari, Esti Hendradi, and Septiani Septiani. "The stability and irritability study of the chitosan–Aloe vera spray gel as wound healing." Journal of Basic and Clinical Physiology and Pharmacology 32, no. 4 (2021): 651–56. http://dx.doi.org/10.1515/jbcpp-2020-0407.

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Abstract Objectives Chitosan is a natural polysaccharide widely used in various clinical applications including regeneration of skin tissue. Aloe vera has properties in healing burns on the skin, anti-inflammatory effect, and leaves a protective layer on the skin after drying so it provides protection to the wound. The spray gel of chitosan–A. vera was developed as a wound healing that has combined of effect of both component and easy to use. The purpose of this study was to determine the physical stability and irritability of chitosan–A. vera spray gel. Methods The spray gel stability test wa

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12

Botham, Philip A., Lesley K. Earl, Julia H. Fentem, Roland Roguet, and Johannes J. M. van de Sandt. "Alternative Methods for Skin Irritation Testing: The Current Status." Alternatives to Laboratory Animals 26, no. 2 (1998): 195–211. http://dx.doi.org/10.1177/026119299802600205.

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The ECVAM Skin Irritation Task Force was established in November 1996, primarily to prepare a report on the current status of the development and validation of alternative tests for skin irritation and corrosion and, in particular, to identify any appropriate non-animal tests for predicting human skin irritation which were sufficiently well-developed to warrant ECVAM supporting their prevalidation/validation. The task force based its discussions around the proposed testing strategy for skin irritation/corrosion emanating from an OECD workshop held in January 1996. The following have been revie

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Deswani, Deswani, Sri Djuwitaningsih, Harpolia Cartika, and Paul Malau. "Irritation Test of Cream Preparations Made from Purple Cabbage Extract Against Healthy Skin Using The Path Test Method." JURNAL INFO KESEHATAN 23, no. 1 (2025): 1–9. https://doi.org/10.31965/infokes.vol23.iss1.1458.

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Testing for skin irritation caused by new substances is a critical component of safety evaluation procedures. Pharmaceutical formulations and active ingredients intended for topical application have the potential to cause skin irritation, necessitating thorough safety assessments prior to public distribution. This study aimed to evaluate the primary irritation potential of a purple cabbage extract cream using the patch test method on healthy older adults. The experimental research involved 18 volunteers, who were administered 0.625% purple cabbage extract cream and a placebo preparation withou

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Deswani, Deswani, Sri Djuwitaningsih, and Harpolia Cartika. "Irritation Test of Cream Preparations Made from Purple Cabbage Extract Against Healthy Skin Using The Path Test Method." JURNAL INFO KESEHATAN 22, no. 4 (2024): 858–66. https://doi.org/10.31965/infokes.vol22.iss4.1458.

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Testing for skin irritation caused by new substances is a critical component of safety evaluation procedures. Pharmaceutical formulations and active ingredients intended for topical application have the potential to cause skin irritation, necessitating thorough safety assessments prior to public distribution. This study aimed to evaluate the primary irritation potential of a purple cabbage extract cream using the patch test method on healthy older adults. The experimental research involved 18 volunteers, who were administered 0.625% purple cabbage extract cream and a placebo preparation withou

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15

Cowley, N. C., and P. M. Farr. "A dose-response study of irritant reactions to sodium lauryl sulphate in patients with seborrhoeic dermatitis and atopic eczema." Acta Dermato-Venereologica 72, no. 6 (1992): 432–35. http://dx.doi.org/10.2340/0001555572432435.

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The susceptibility of the skin of patients with seborrhoeic dermatitis to surfactant irritation was investigated and compared to that of a group of normal subjects and patients with a history of atopic eczema. Responses to six concentrations of sodium lauryl sulphate (SLS), applied to forearm skin, were assessed clinically and measured by laser Doppler flowmetry. Analysis of dose-response curves showed statistically significant increased susceptibility to SLS-induced irritation in patients with seborrhoeic dermatitis and atopic eczema compared with normal subjects. Increased susceptibility to

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KS, Maneesha, Sreedevi AP, Anu Joy, Reeshma CR, Sibi Narayanan, and Adithya Peethambara Panicker. "CLINICAL EVALUATION OF THE SKIN BRIGHTENING EFFICACY AND SAFETY OF KUMKUMADI THAILAM: AN EIGHT-WEEK OPEN-LABEL PILOT STUDY." International Journal of Research in Ayurveda and Pharmacy 16, no. 2 (2025): 84–89. https://doi.org/10.7897/2277-4343.16249.

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Kumkumadi Thailam, a classical Ayurvedic formulation, is traditionally used to enhance skin brightness and address uneven skin tone and pigmentation. Despite its historical use, scientific evidence supporting its efficacy and safety remains limited. This study aimed to evaluate the skin brightening efficacy and safety of Kumkumadi Thailam in healthy adults over an 8-week period. An open-label, single-arm pilot clinical study was conducted with 30 healthy volunteers aged 20–60 years at Sitaram Ayurveda Specialty Hospital, Thrissur, India. Participants applied Kumkumadi Thailam topically once da

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Unwin, Steven E., Timothy A. Weyrauch, and Carole L. Smith. "Primary Skin Irritation Study on Aminoguanidine HC1 in Rabbits." Journal of the American College of Toxicology 11, no. 6 (1992): 714. http://dx.doi.org/10.3109/10915819209142107.

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Kandárová, Helena, Manfred Liebsch, Elisabeth Schmidt, et al. "Assessment of the Skin Irritation Potential of Chemicals by Using the SkinEthic Reconstructed Human Epidermal Model and the Common Skin Irritation Protocol Evaluated in the ECVAM Skin Irritation Validation Study." Alternatives to Laboratory Animals 34, no. 4 (2006): 393–406. http://dx.doi.org/10.1177/026119290603400407.

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19

Rausch, L., E. C. Bisinger, A. Sharma, and R. Rose. "Use of the Domestic Swine as an Alternative Animal Model for Conducting Dermal Irritation/Corrosion Studies on Fatty Amine Ethoxylates." International Journal of Toxicology 22, no. 4 (2003): 317–23. http://dx.doi.org/10.1080/10915810305123.

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The dermal irritation/corrosion potential of four fatty amine ethoxylates was evaluated using domestic swine as an alternative animal model. The weanling pig was chosen for this study due to the similarity of its skin to human skin with respect to structure and physiology. The four products, Armostat® 310 (tallow bis (2-hydroxyethyl) amine), Armostat® 410 (coco bis (2-hydroxyethyl) amine), Armostat® 710 (oleyl bis (2-hydroxyethyl) amine), and Armostat® 1800 (stearyl bis (2-hydroxyethyl) amine) were applied to the skin of three domestic swine for 4 hours in accordance with internationally accep

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Maulina, Novia, Faisal Akhmal Muslikh, Ginanjar Putri Nastiti, et al. "Formulasi Sabun Mandi Cair Berbasis Virgin Coconut Oil (VCO): Optimalisasi Pemanfaatan Produk Lokal Untuk Perawatan Kulit dan Pencegahan Dehidrasi." Bioscientist : Jurnal Ilmiah Biologi 13, no. 1 (2025): 628. https://doi.org/10.33394/bioscientist.v13i1.14160.

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Skin dehydration is a common issue affecting 40–50% of the adult population, resulting in dry, rough, and dull skin, as well as itching, irritation, and premature aging. The "back to nature" trend has increased interest in natural skincare products that are more environmentally friendly and gentler on the skin. Virgin coconut oil (VCO) is a popular natural ingredient known for its ability to maintain skin moisture and provide protection. This study aims to develop a liquid soap formulation using VCO to address skin dehydration. The research methods included formulation and evaluation of liquid

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Ikeda, Hidefumi, and Hideki Nishiura. "Study of in vitro Skin Irritation Test Targeted for Sensitive Skin." Journal of Society of Cosmetic Chemists of Japan 47, no. 1 (2013): 9–18. http://dx.doi.org/10.5107/sccj.47.9.

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田, 辉. "Study of the Skin Irritation and Skin Allergenic Effect of Miconazole Nitrate Liniment." Pharmacy Information 08, no. 01 (2019): 16–28. http://dx.doi.org/10.12677/pi.2019.81003.

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23

Basketter, D. A., and H. A. Griffiths. "A study of the relationship between susceptibility to skin stinging and skin irritation." Contact Dermatitis 29, no. 4 (1993): 185–88. http://dx.doi.org/10.1111/j.1600-0536.1993.tb03534.x.

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Tambake, Ms Bhagyashri Mallinath. "A Review: Pediatric Gel from Apple Wood." International Journal for Research in Applied Science and Engineering Technology 13, no. 4 (2025): 4373–77. https://doi.org/10.22214/ijraset.2025.68997.

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Abstract: Researchers are looking at plant-derived actives for skin care, particularly for kids with sensitive skin, as a result of the growing need for safe, herbal-based paediatric formulations. The creation and assessment of a paediatric gel using apple wood extract (Malus domestic), which has antibacterial, calming, and antioxidant qualities, is the main goal of this work. Apple wood, which is sometimes disregarded in traditional medicine, is perfect for treating minor skin irritations, rashes, or inflammation in children because it contains healthy phytochemicals including polyphenols, fl

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Rajesh, Kumawat, Sachdev Mukta, Ramnane Mukesh, B. Swathi, and U. V. Babu. "Assessment of Cumulative Irritation and Sensitization Potential of Himalaya's Baby Skin Care Products in Adult Healthy Volunteers by Human Repeat Insult Patch Test (HRIPT)." International Journal of Toxicological and Pharmacological Research 12, no. 6 (2022): 174–84. https://doi.org/10.5281/zenodo.11669534.

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This study was to assess the mildness, gentleness and allergenic potency of 18 marketed baby skin care products. This open-label, controlled, single-center, HRIPT was conducted in 2 studies as per BIS 4011:2018 guidelines. Each study included 200 healthy participants in the age of 18-65years (of either sex). 10 products in study 1 and 8 products in study 2 were evaluated in different phases. Induction phase, products were repeatedly applied on the back of study subjects in the form of occlusive patch for 24 hours for 3 times a week, for 3 weeks. The reactions were assessed 48 hours after every

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Easter, C.H. Situmorang, A. Bara Robert, Warouw Veibe, et al. "Testing of UV Protection Activity, SPF Determination, and Irritation Assessment of Coastal Vegetation Ipomoea Pes-Caprae." INTERNATIONAL JOURNAL OF HEALTH & MEDICAL RESEARCH 03, no. 11 (2024): 805–10. https://doi.org/10.5281/zenodo.14192038.

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Total solar radiation contains approximately 10% ultraviolet light. Ultraviolet rays have benefits such as providing warmth, light, and helping to synthesise vitamin D3. However, ultraviolet rays can also have negative impacts on the skin such as browning, hyperpigmentation, erythema, and premature ageing. Natural sunscreens with high SPF are useful in reducing the negative effects of ultraviolet rays. This study aims to determine anti-UV activity, SPF value, and assessment of human skin irritation or allergy to sunscreen cream from Ipomoea pes-caprae leaves. Anti-UV activity test and SPF valu

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Novasari, Hastrina, Asti Pratiwi, and Nopri Mahmiara. "EFEKTIVITAS FORMULASI SEDIAAN LOTION DARI EKSTRAK ETANOL DAUN ALPUKAT (PERSEA AMERICANA MILL) SEBAGAI PELEMBAB KULIT." JURNAL FARMASIMED (JFM) 3, no. 2 (2021): 57–62. http://dx.doi.org/10.35451/jfm.v3i2.571.

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Avocado plant can be formulated into a lotion because preparation based on previous research avocado leavescontain high antioxidant is represented with flavonoid compound. The purpose of this study is to know avocado leaves can be formulated into the preparation of lotion and to know the preparation of lotion from extract etanol avocado leavescan moisturaize the skin. The research uses exsperimental method. Avocado leaves is exstrach by maceration process. Exanination of lotion preparation by this research is phytochemical screening test, pH test,irritation test and skin moisturaise test

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Unwin, Steven E., Timothy A. Weyrauch, and Carole L. Smith. "Primary Skin Irritation Study on Bismuth Sucrose Octasulfate in Rabbits." Journal of the American College of Toxicology 11, no. 6 (1992): 721. http://dx.doi.org/10.3109/10915819209142114.

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Ma, Xue, Huan Wang, Yanqing Song, and Yao Pan. "Skin irritation potential of cosmetic preservatives: An exposure‐relevant study." Journal of Cosmetic Dermatology 20, no. 1 (2020): 195–203. http://dx.doi.org/10.1111/jocd.13502.

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Han, Sang Mi, Kwang Gill Lee, Joo Hong Yeo, and Sok Cheon Pak. "Dermal and Ocular Irritation Studies of Honeybee (Apis mellifera L.) Venom." American Journal of Chinese Medicine 40, no. 04 (2012): 795–800. http://dx.doi.org/10.1142/s0192415x12500590.

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The aim of this study was to access the irritant properties of bee venom (BV) after its application to skin and eye mucous membranes of the rabbit. The animals were also observed for clinical signs and mortality after the application of the test material. Six animals were used for the skin irritation test and nine rabbits for the eye irritation test. The acute BV application to the rabbit skin revealed no appreciable clinical signs throughout the observation period of 72 h and there was no mortality seen. In the eye irritation test, eye reactions were read and graded 24, 48, 72, 96 and 168 h a

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Van de Kerkhof, P. C., and M. G. Timmerman. "The effect of clobetasol-17-propionate and crude coal tar on dithranol-induced inflammation. A clinical and biochemical study." Acta Dermato-Venereologica 70, no. 5 (1990): 434–37. http://dx.doi.org/10.2340/0001555570434437.

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Clobetasol-17-propionate (CP) and crude coal tar (CT) have an anti-inflammatory potential. Both agents have been advocated to suppress irritation of the skin during dithranol treatment. The effect of CP and CT on dithranol-induced irritation was studied by the assessment of erythema and measurement of alkaline phosphatase (ALP) as a direct reflection of the metabolic activity of the endothelial cells. Dithranol was applied for 2 h in the relatively high concentration of 10%, which resulted in a marked inflammation of the skin in all volunteers. Neither CP nor CT influenced the erythema. In con

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Babu, RJ, A. Chatterjee, E. Ahaghotu, and M. Singh. "Percutaneous absorption and skin irritation upon low-level prolonged dermal exposure to nonane, dodecane and tetradecane in hairless rats." Toxicology and Industrial Health 20, no. 6-10 (2004): 109–18. http://dx.doi.org/10.1191/0748233704th197oa.

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Even though the dermal toxicity of hydrocarbon fuels has been well established in the literature, there is little information available on the dermal penetration kinetics and irritation potential of the individual hydrocarbons. The penetration and skin retention of nonane, dodecane and tetradecane was assessed in vitro using hairless rats’ skin. The effects of unocclusive dermal exposures of these chemicals (15 mL every 2 h for 8 h a day for four days) on the transepidermal water loss (TEWL) and erythema were measured in CD hairless rats. The expression of interleukin 1a (IL-1a) and TNF-a in t

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Obonyo, Ernest Bisanga, and Ambrose Asiimwe. "IMPACT OF COCK UP SPLINTS TO CHILDREN WITH WRIST DROP IN MULAGO ORTHOPAEDIC WORKSHOP. A CROSS-SECTIONAL STUDY." SJ Orthopaedic Research Africa 1, no. 8 (2025): 6. https://doi.org/10.51168/v0bnv777.

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Background The management of wrist drops involves the use of a wrist splint commonly known as a cock-up splint and physical therapy. The study aims to assess the Impact of cock-up splints on children with wrist drops in the MNRH Orthopedic Workshop. Methodology A cross-sectional study using quantitative data collection methods to collect data from 45 Respondents who were wrist drop patients between 10 to 18 years old. Results A significant impact of cock-up splints in the management of wrist drops was reported. The majority of the respondents 18(40%) had improved wrist alignment, 10(26.7%) had

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Aoyagi, Kazuhiro, Michael Zakrewsky, and Samir Mitragotri. "Formulating propranolol as an amorphous melt affords reduced skin irritation potential for transdermal drug delivery." TECHNOLOGY 03, no. 04 (2015): 214–38. http://dx.doi.org/10.1142/s2339547815500107.

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Oral propranolol is commonly the first-line treatment of infantile hemangioma. However, oral delivery of propranolol is limited by systemic side effects, particularly in infants. Topical application may be a more patient friendly alternative while concurrently affording targeted delivery to the site of the skin lesion. Unfortunately, dose-dependent skin irritation is typically observed when propranolol is applied topically. Of additional concern, irritation is often exacerbated by organic solvents required to formulate propranolol. To address these concerns, we present novel formulations of pr

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C Ulfa, Cut Fatia, Meutia Zuhra, Rini Safriani, and Fitri Yani. "Formulation of Robusta Coffee Bean (Coffea Robusta Lindl. Ex De Will) Ethanol Extract Peel-off Mask Preparation." International Journal of Research and Innovation in Applied Science IX, no. VIII (2024): 511–18. http://dx.doi.org/10.51584/ijrias.2024.908044.

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Ultraviolet rays and other factors that form free radicals can cause accelerated skin aging. Robusta coffee (Coffea robusta Lindl. Ex De Will) contains xanthin alkaloids and chlorogenic acid that has antioxidant activity. This is an experimental study that aims to formulate ethanol from robusta coffee beans into a peel-off mask preparation and test various quality parameters. Robusta coffee bean ethanol extracted by maceration and made into 1%, 3%, and 5% concentration peel-off mask respectively. Peel-off mask preparations then undergo several tests including homogeneity, viscosity, pH, stabil

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Susanti, Ni Made Pitri, I. Nyoman Triadhi Wisesa, and Chenme Juwianti. "IN SILICO TOXICITY OF ANTHOCYANIN COMPOUNDS (CYANIDIN AND PEONIDIN)." Journal of Pharmaceutical Science and Application 5, no. 1 (2023): 53. http://dx.doi.org/10.24843/jpsa.2023.v05.i01.p07.

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Backgrounds: Cyanidin and peonidin, anthocyanin compounds, have many in silico, in vitro, and in vivo activities, including antioxidant, anticancer, antihyperlipidemic, and antidiabetic. Toxicity testing is carried out to determine the potential hazard that may be produced by the test compound. Objective: This study was aimed to determine the in silico toxicity of anthocyanins (cyanidin and peonidin) using Toxtree v3.1.0 software. Methods: In silico toxicity testing was carried out using 2D structures of cyanidin and peonidin with Cramer rules, Verhaar scheme, Benigni/Bossa rulebase, Kroes TTC

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Bagchi, Debasis, Yasuhiro Shikishima, Orie Yoshinari, et al. "Safety and Toxicological Evaluation of a Novel Citrus Sudachi Extract Powder." Functional Foods in Health and Disease 6, no. 10 (2016): 677. http://dx.doi.org/10.31989/ffhd.v6i10.301.

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Background: Citrus sudachi, an evergreen tree found primarily in the prefecture of Tokushima, Japan, is a widely used popular citrus fruit used in cooking and also consumed as a juice. Citrus sudachi peels are rich in flavonoids including sudachitin (5,7,4’-trihydroxy-6,8,3’-trimethoxyflavone), and exhibit potent antioxidant, antimicrobial and anti-diabetic properties, while several limonoids and their glucosides are found in its seeds. We examined the broad spectrum safety of a novel light yellow to golden yellow Citrus sudachi Extract Powder (organic, nutritive) from the dried fruit rind (25

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최민지 and Bae-Hwan Kim. "The Comparative Validation Study of Commercial 3D Skin Models for Alternative Skin Irritation Tests." Journal of Investigative Cosmetology 13, no. 1 (2017): 15–20. http://dx.doi.org/10.15810/jic.2017.13.1.003.

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Lee, Ye-Jin, Yang Xu, and Chang-Gu Hyun. "5,7-Dihydroxy-4-Methylcoumarin as a Functional Compound for Skin Pigmentation and Human Skin Safety." Pharmaceuticals 18, no. 4 (2025): 463. https://doi.org/10.3390/ph18040463.

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Background/Objectives: This study aims to investigate the effects of 5,7-dihydroxy-4-methylcoumarin (5,7D-4MC) on melanogenesis in B16F10 murine melanoma cells and to evaluate its safety as a potential ingredient for functional cosmetics and therapeutic agents targeting pigmentation-related disorders. Method: The cytotoxicity of 5,7D-4MC was assessed using an MTT assay, and melanin content and tyrosinase activity were measured at different concentrations (25, 50, 100 µM). Western blot analyses were conducted to evaluate the expression of key melanogenesis-related proteins (TYR, TRP-1, TRP-2, a

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Politano, Valerie T., Daniel A. Isola, Jon Lalko, and Anne Marie Api. "The Effects of Vehicles on the Human Dermal Irritation Potentials of Allyl Esters." International Journal of Toxicology 25, no. 3 (2006): 183–93. http://dx.doi.org/10.1080/10915810600683275.

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Allyl esters, frequently used in the fragrance industry, often contain a certain percentage of free allyl alcohol. Allyl alcohol is known to have a potential for delayed skin irritation. Also present in the finished product are different solvent systems, or vehicles, which are used to deliver the fragrances based upon their intended application. This study was conducted to determine whether different vehicles affect the skin irritation potential of five different allyl esters. The allyl esters tested were allyl amyl glycolate, allyl caproate, allyl (cyclohexyloxy)acetate, allyl cyclohexylpropi

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Arifin, Arfiani, Nur Ida, and Rosmiyanti Rosmiyanti. "FORMULASI DAN UJI IRITASI SEDIAAN LULUR KRIM CANGKANG SOTONG (Sepia sp.) TERHADAP KELINCI (Oryctolagus cuniculus)." Jurnal Riset Kefarmasian Indonesia 5, no. 1 (2023): 68–83. http://dx.doi.org/10.33759/jrki.v5i1.359.

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Cuttlefish shell (Sepia sp.) contains calcium carbonate which has benefits in removing dead skin cells, regulating skin pigmentation, shrinking pores, removing acne and black spots and making skin brighter. The aims of this study were to formalize dosage form of cuttlefish shell cream scrub (Sepia sp.) that meets the physical quality requirements and to determine the potential irritation of cuttlefish shell (Sepia sp.) cream scrubs in rabbits (Oryctolagus cuniculus). Reseacrh methods include the dosage form of cuttlefish shell powder using sieve mesh 44, cream scrub formulations with variation

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Słoczyńska, Karolina, Justyna Popiół, Agnieszka Gunia-Krzyżak, Paulina Koczurkiewicz-Adamczyk, Paweł Żmudzki, and Elżbieta Pękala. "Evaluation of Two Novel Hydantoin Derivatives Using Reconstructed Human Skin Model EpiskinTM: Perspectives for Application as Potential Sunscreen Agents." Molecules 27, no. 6 (2022): 1850. http://dx.doi.org/10.3390/molecules27061850.

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This study aimed to assess two novel 5-arylideneimidazolidine-2,4-dione (hydantoin) derivatives (JH3 and JH10) demonstrating photoprotective activity using the reconstructed human skin model EpiskinTM. The skin permeability, irritation, and phototoxicity of the compounds was evaluated in vitro. Moreover, the in vitro genotoxicity and human metabolism of both compounds was studied. For skin permeation and irritation experiments, the test compounds were incorporated into a formulation. It was shown that JH3 and JH10 display no skin irritation and no phototoxicity. Both compounds did not markedly

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Kao, Hung-Yuan, Shu-I. Jen, Yu-Chen Kao, Zong-Keng Kuo, and Szu-Hsiu Liu. "ANTIOXIDANT ACTIVITIES AND IN VITRO WOUND HEALING EFFECTS OF META COLLAGEN." Journal of Applied Biological Sciences 17, no. 3 (2023): 500–509. https://doi.org/10.71336/jabs.1222.

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The imbalance of reactive oxygen species (ROS) may cause oxidative stress which is harmful to skin health. Moreover, oxidative stress could also impair the healing of a wound. Antioxidants have been demonstrated their benefits to skin health and wound healing. Previous studies have shown collagen tripeptide has beneficial effects on skins, such as alleviating photoaging, improving skin elasticity and hydration, improving type I collagen synthesis and more. In this study, anti-oxidant activities and in vitro wound healing effects of Meta collagen (Highly content dipeptide and tripeptide) were i

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Hung-Yuan, Kao, Jen Shu-I, Kao Yu-Chen, Kuo Zong-Keng, and Liu Szu-Hsiu. "ANTIOXIDANT ACTIVITIES AND IN VITRO WOUND HEALING EFFECTS OF META COLLAGEN." Journal of Applied Biological Sciences 17, no. 3 (2023): 500–509. https://doi.org/10.5281/zenodo.10035502.

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The imbalance of reactive oxygen species (ROS) may cause oxidative stress which is harmful to skin health. Moreover, oxidative stress could also impair the healing of a wound. Antioxidants have been demonstrated their benefits to skin health and wound healing. Previous studies have shown collagen tripeptide has beneficial effects on skins, such as alleviating photoaging, improving skin elasticity and hydration, improving type I collagen synthesis and more. In this study, anti-oxidant activities and <i>in vitro</i> wound healing effects of Meta collagen (Highly content dipeptide and tripeptide)

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Asyaul Wasiah, Ida Susila, and Salma Nabila. "The Relationship Between Diaper Use and Skin Irritation Incidence in Toddlers Aged 0-3 Years at PMB Ani Mahmudah SST Lamongan." EMBRIO 13, no. 2 (2021): 164–71. http://dx.doi.org/10.36456/embrio.v13i2.4044.

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Diaper rash is a skin problem in the genital area of infants and toddlers, which is characterized by the appearance of red patches on the skin. Baby's skin is still sensitive because its functions are still developing, especially in the epidermis or the outermost layer of the skin which provides natural protection for the skin from the surrounding environment. Continuous use of diapers for too long will increase the sensitivity of the baby's skin so that it can cause skin irritation. That's why baby's skin is more sensitive and prone to skin disorders. Disorders that usually arise in the for

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Sharma, Akanksha, and Rishabha Malviya. "Effects of Corona Virus on the Skin: Symptoms and Risks." Open Dermatology Journal 14, no. 1 (2020): 28–30. http://dx.doi.org/10.2174/1874372202014010028.

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Coronavirus is a disease that affects mainly the upper respiratory tract, but in somecases, it can also affect the skin. This study aims to describe the effect of coronavirus on the skin function. Skin gets affected easily because coronavirus first comes into contact with the skin and mucous membrane. Numerous studies are investigating the symptoms of coronavirus appearing on the skin in different forms like rashes, blisters, irritation, dermatitis, etc. The excessive use of sanitizers and soaps can also cause skin problems. Personal protective equipment can also cause irritation to the skin a

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Boyce, John M., Susan Kelliher, and Nancy Vallande. "Skin Irritation and Dryness Associated With Two Hand-Hygiene Regimens: Soap-and-Water Hand Washing Versus Hand Antisepsis With an Alcoholic Hand Gel." Infection Control & Hospital Epidemiology 21, no. 7 (2000): 442–48. http://dx.doi.org/10.1086/501785.

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Objective:To compare the frequency of skin irritation and dryness associated with using an alcoholic–hand-gel regimen for hand antisepsis versus using soap and water for hand washing.Design:Prospective randomized trial with crossover design. Irritation and dryness of nurses' hands were evaluated by self-assessment and by visual assessment by a study nurse. Epidermal water content of the dorsal surface of nurses' hands was estimated by measuring electrical capacitance of the skin.Setting:Miriam Hospital, a 200-bed university-affiliated teaching hospital.Participants:Thirty-two nurses working on

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Geppe, N. A., M. D. Velikoretskaya, L. R. Sakaniya, et al. "Sensitive Skin Management in Children up to 7 Years Old." Doctor.Ru 22, no. 7 (2023): 18–23. http://dx.doi.org/10.31550/1727-2378-2023-22-7-18-23.

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Aim. To assess the effectiveness of skin cosmetics in skin restoration (decrease in dryness, irritation, itching) in children up to 7 years Design. An observative open clinical noncomparative study. Materials and methods. The study enrolled 50 children: 30 children with sensitive skin and 20 participants with head cradle caps. The study included 2 visits in the office. During the examination, the doctor assessed the severity of dryness and itching in children with sensitive skin, and the severity of dryness, itching and flaking of the scalp in children with cradle cap. The values varied 0 to 1

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Kim, Sang Ho, Myeong kyu Park, Ja Kyung Seol, et al. "Evaluation of potential eye or skin irritation/corrosion in rabbit exposed to TiO2 photocatalyst (GST)." Environmental Analysis Health and Toxicology 36, no. 3 (2021): e2021022. http://dx.doi.org/10.5620/eaht.2021022.

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TiO2 NPs photocatalyst is widely used in a variety of applications and products in the environmental and energy fields, including self-cleaning surfaces, air and water purification systems, sterilization, hydrogen evolution, and photoelectrochemical conversion. The possible biological and safety effects of TiO2 dermal exposure and absorption have not been well studied and more investigations on the potential health hazards of the TiO2 are needed. This study aimed to investigate potential effect of local lesions (eye and skin irritation/corrosion) for new TiO2 material powder, GST produced thro

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Yusof, Nor Zuliana, Siti Salwa Abd Gani, Zafarizal Aldrin Azizul Hasan, and Zainab Idris. "Skin and Eye Irritation Assessment of Oil Palm (Elaeis guineensis) Leaf Extract for Topical Application." International Journal of Toxicology 37, no. 4 (2018): 335–43. http://dx.doi.org/10.1177/1091581818773979.

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Many types of phytochemicals have been found to be present in oil palm leaf and could potentially be used as functional ingredients for skincare product. However, as of today, there is no published report on hazard identification and safety assessment of oil palm ( Elaeis guineensis) leaf extract (OPLE), particularly on skin and eye irritation. In this study, potential hazard of OPLE on skin and eye irritation was evaluated as an initial step to the safety assessment of OPLE. In vitro cell viability study of OPLE on normal human dermal fibroblasts showed that OPLE was nontoxic to the cells wit

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