Relevant bibliographies by topics / Sla-6

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Academic literature on the topic 'Sla-6'

Author: Grafiati
Published: 4 June 2021
Last updated: 4 February 2022

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Journal articles on the topic "Sla-6"

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Ali, Mir Amaan, Kate T. Carroll, Robert C. Rennert, Thomas Hamelin, Leon Chang, Brian P. Lemkuil, Mayur Sharma, et al. "Stereotactic laser ablation as treatment for brain metastases that recur after stereotactic radiosurgery: a multiinstitutional experience." Neurosurgical Focus 41, no. 4 (October 2016): E11. http://dx.doi.org/10.3171/2016.7.focus16227.

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OBJECTIVE Therapeutic options for brain metastases (BMs) that recur after stereotactic radiosurgery (SRS) remain limited. METHODS The authors provide the collective experience of 4 institutions where treatment of BMs that recurred after SRS was performed with stereotactic laser ablation (SLA). RESULTS Twenty-six BMs (in 23 patients) that recurred after SRS were treated with SLA (2 patients each underwent 2 SLAs for separate lesions, and a third underwent 2 serial SLAs for discrete BMs). Histological findings in the BMs treated included the following: breast (n = 6); lung (n = 6); melanoma (n = 5); colon (n = 2); ovarian (n = 1); bladder (n = 1); esophageal (n = 1); and sarcoma (n = 1). With a median follow-up duration of 141 days (range 64–794 days), 9 of the SLA-treated BMs progressed despite treatment (35%). All cases of progression occurred in BMs in which < 80% ablation was achieved, whereas no disease progression was observed in BMs in which ≥ 80% ablation was achieved. Five BMs were treated with SLA, followed 1 month later by adjuvant SRS (5 Gy daily × 5 days). No disease progression was observed in these patients despite ablation efficiency of < 80%, suggesting that adjuvant hypofractionated SRS enhances the efficacy of SLA. Of the 23 SLA-treated patients, 3 suffered transient hemiparesis (13%), 1 developed hydrocephalus requiring temporary ventricular drainage (4%), and 1 patient who underwent SLA of a 28.9-cm3 lesion suffered a neurological deficit requiring an emergency hemicraniectomy (4%). Although there is significant heterogeneity in corticosteroid treatment post-SLA, most patients underwent a 2-week taper. CONCLUSIONS Stereotactic laser ablation is an effective treatment option for BMs in which SRS fails. Ablation of ≥ 80% of BMs is associated with decreased risk of disease progression. The efficacy of SLA in this setting may be augmented by adjuvant hypofractionated SRS.
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Rennert, Robert C., Kate T. Carroll, Mir Amaan Ali, Thomas Hamelin, Leon Chang, Brian P. Lemkuil, and Clark C. Chen. "Safety of stereotactic laser ablations performed as treatment for glioblastomas in a conventional magnetic resonance imaging suite." Neurosurgical Focus 41, no. 4 (October 2016): E7. http://dx.doi.org/10.3171/2016.8.focus16217.

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OBJECTIVE Stereotactic laser ablation (SLA) is typically performed in the setting of intraoperative MRI or in a staged manner in which probe insertion is performed in the operating room and thermal ablation takes place in an MRI suite. METHODS The authors describe their experience, in which SLA for glioblastoma (GBM) treatment was performed entirely within a conventional MRI suite using the SmartFrame stereotactic device. RESULTS All 10 patients with GBM (2 with isocitrate dehydrogenase 1 mutation [mIDH1] and 8 with wild-type IDH1 [wtIDH1]) were followed for > 6 months. One of these patients underwent 2 independent SLAs approximately 12 months apart. Biopsies were performed prior to SLA for all patients. There were no perioperative morbidities, wound infections, or unplanned 30-day readmissions. The average time for a 3-trajectory SLA (n = 3) was 436 ± 102 minutes; for a 2-trajectory SLA (n = 4) was 321 ± 85 minutes; and for a single-trajectory SLA (n = 4) was 254 ± 28 minutes. No tumor recurrence occurred within the blue isotherm line ablation zone, although 2 patients experienced recurrence immediately adjacent to the blue isotherm ablation line. Overall survival for the patient cohort averaged 356 days, with the 2 patients who had mIDH1 GBMs exhibiting the longest survival (811 and 654 days). CONCLUSIONS Multitrajectory SLA for treatment of GBM can be safely performed using the SmartFrame stereotactic device in a conventional MRI suite.
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Stacey, Katryn J., and Jenefer M. Blackwell. "Immunostimulatory DNA as an Adjuvant in Vaccination against Leishmania major." Infection and Immunity 67, no. 8 (August 1, 1999): 3719–26. http://dx.doi.org/10.1128/iai.67.8.3719-3726.1999.

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ABSTRACT Oligodeoxynucleotides (ODN) which contain immunostimulatory CG motifs (CpG ODN) can promote T helper 1 (Th1) responses, an adjuvant activity that is desirable for vaccination against leishmaniasis. To test this, susceptible BALB/c mice were vaccinated with soluble leishmanial antigen (SLA) with or without CpG ODN as adjuvant and then challenged with Leishmania major metacyclic promastigotes. CpG ODN alone gave partial protection when injected up to 5 weeks prior to infection, and longer if the ODN was bound to alum. To demonstrate an antigen-specific adjuvant effect, a minimum of 6 weeks between vaccination and infection was required. Subcutaneous administration of SLA alone, SLA plus alum, or SLA plus non-CpG ODN resulted in exacerbated disease compared to unvaccinated mice. Mice receiving SLA plus CpG ODN showed a highly significant (P < 5 × 10−5) reduction in swelling compared to SLA-vaccinated mice and enhanced survival compared to unvaccinated mice. The modulation of the response to SLA by CpG ODN was maintained even when mice were infected 6 months after vaccination. CpG ODN was not an effective adjuvant for antibody production in response to SLA unless given together with alum, when it promoted production of immunoglobulin G2a, a Th1-associated isotype. Our results suggest that with an appropriate antigen, CpG ODN would provide a stable, cost-effective adjuvant for use in vaccination against leishmaniasis.
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Le Sage, Gregory Peter. "Thermal Frequency Drift of 3D Printed Microwave Components." Metals 10, no. 5 (April 29, 2020): 580. http://dx.doi.org/10.3390/met10050580.

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Fabrication of microwave slot array antennas and waveguide bandpass and notch filters using 3D printing has significant advantages in terms of speed and cost even for parts with high mechanical complexity. One disadvantage of Stereolithography (SLA) 3D printed, copper plated microwave components is that some SLA resins have a high Coefficient of Thermal Expansion (CTE), quoted in micrometers per meter per degree or 10−6 per degree. Compared to typically used metals such as aluminum (CTE 24 × 10−6·K−1) and copper (CTE 17 × 10−6·K−1), SLA resin can have CTE above 100 × 10−6·K−1. Resonant structures experience significant frequency drift with temperature changes on the order of 10–50 °C. The issue of 3D printed microwave structures changing frequency characteristics significantly with temperature shift has not been addressed or reviewed in current literature. We measured and simulated the effect of temperature change on a slot array, cavity notch filters, and post loaded waveguide bandpass filters. We tested several types of SLA resin, different plating techniques, and also Direct Metal Laser Sintering (DMLS) and Binder Infusion metal 3D printing. Performance as a function of temperature is presented for these alternatives.
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Chen, Clark C., Robert Rennert, Usman Khan, Stephen B. Tatter, Melvin Field, Brian Toyota, Peter Edward Fecci, et al. "223 Procedural Safety of Stereotactic Laser Ablation (SLA) and Associated Hospital Stay: Outcome from the First Hundred Patient from LAANTERN Prospective Registry." Neurosurgery 64, CN_suppl_1 (August 24, 2017): 261. http://dx.doi.org/10.1093/neuros/nyx417.223.

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Abstract INTRODUCTION We examined the procedural safety and length of hospital stay for patients who underwent stereotactic laser ablation (SLA). METHODS Patients undergoing stereotactic laser ablation were prospectively enrolled in the Laser Ablation of Abnormal Neurological Tissue using Robotic Neuroblate System (LAANTERN) registry. Data from the first 100 enrolled patients are presented. RESULTS >The demographic of the patient cohort consisted of 58% females and 42% males. The mean age and KPS of the cohort were 51 (±17) years and 83 (±15), respectively. 87% of the SLA-treated patients had undergone prior surgical or radiation treatment. In terms of indications, 84% of the SLAs were performed as treatment for brain tumor and 16% were performed as treatment for epilepsy. In terms of the procedure, 79% of the SLA patients underwent treatment of a single lesion. In 72% of the SLA treated patients, >90% of the target lesion was ablated. The average procedural time was 188.2 minutes (range: 48–368 minutes). The average blood loss per procedure was 17.7 cc (range: 0–300cc). In terms of hospitalization, the average length of Intensive Care stay was 38.1 hours (range 0335). The number of hours post-procedure before patient discharge was 61.1 hours (range 6–612). 85% of the patients were discharged home. There were 15 adverse events at the one-month follow-up (12%), with two events definitively related to the procedure (2%), including one patient with post-operative intraventricular hemorrhage and another with post-procedural gait compromise. CONCLUSION SLA is a minimally invasive procedure with favorable profile in terms of safety and hospital length of stay.
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Kusza, S., L. Flori, Y. Gao, A. Teillaud, R. Hu, G. Lemonnier, Z. Bősze, E. Bourneuf, S. Vincent-Naulleau, and C. Rogel-Gaillard. "Transcription specificity of the class Ib genes SLA-6, SLA-7 and SLA-8 of the swine major histocompatibility complex and comparison with class Ia genes." Animal Genetics 42, no. 5 (February 1, 2011): 510–20. http://dx.doi.org/10.1111/j.1365-2052.2010.02170.x.

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Nieuwhof, M., F. Garretsen, and J. C. van Oeveren. "Growth analyses of tomato genotypes grown under low energy conditions." Netherlands Journal of Agricultural Science 39, no. 3 (September 1, 1991): 191–96. http://dx.doi.org/10.18174/njas.v39i3.16541.

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Growth analyses were carried out on young plants of 15 genotypes, grown initially at 19/14 degrees C day/night temperatures for an 8 h day at low light intensity and subsequently at the night temperatures of 6, 10 and 14 degrees C. Significant genotypic differences occurred for relative growth rate (RGR), net assimilation rate (NAR), leaf area ratio (LAR), specific leaf area (SLA) and leaf weight ratio (LWR). RGR, LAR and SLA increased and LWR decreased at higher night temperatures. A strong negative correlation was observed between NAR and LAR and NAR and SLA whilst a positive correlation was noted between LAR and SLA. Plant weight was strongly influenced by seed size. (Abstract retrieved from CAB Abstracts by CABI’s permission)
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Chavoshian, Omid, Mahdieh Arabsalmani, Mahmoud Reza Jaafari, Ali Khamesipour, Azam Abbasi, Zahra Saberi, and Ali Badiee. "A Phospholipase-A Activity in Soluble Leishmania Antigens Causes Instability of Liposomes." Current Drug Delivery 17, no. 9 (October 27, 2020): 806–14. http://dx.doi.org/10.2174/1567201817666200731164002.

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Aim: This study aimed to investigate the existence of phospholipase-A (PLA) activity in Soluble L. major Antigens (SLA) because of no reports for it so far. Liposomes were used as sensors to evaluate PLA activity. Objective: Liposomal SLA consisting of Egg Phosphatidylcholine (EPC) or Sphingomyelin (SM) were prepared by two different methods in different pH or temperatures and characterized by Dynamic Light Scattering (DLS) and Thin Layer Chromatography (TLC). Methods: Lipid hydrolysis led to the disruption of EPC liposomal SLA in both methods but the Film Method (FM) produced more stable liposomes than the Detergent Removal Method (DRM). Results: The preparation of EPC liposomal SLA at pH 6 via FM protected liposomes from hydrolysis to some extent for a short time. EPC liposomes but not SM liposomes were disrupted in the presence of SLA. Conclusion: Therefore, a phospholipid without ester bond such as SM should be utilized in liposome formulations containing PLA as an encapsulating protein.
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Rawson, HM, PA Gardner, and MJ Long. "Sources of Variation in Specific Leaf Area in Wheat Grown at High Temperature." Functional Plant Biology 14, no. 3 (1987): 287. http://dx.doi.org/10.1071/pp9870287.

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In the belief that specific leaf area (SLA, cm2 g1 dry weight) may be correlated with plant growth rate under certain conditions, and thus may be used in selecting genotypes for high growth rates, studies were commenced to examine the main sources of variation in SLA. In most studies, wheat plants were grown in controlled environments with high mean temperature and vapour pressure deficit and with varying radiation regimes. All environmental variables followed cosine patterns which in amplitude mimicked field conditions. Specific leaf area varied depending on: (1) location along a leaf: it decreased from tip to base by some 35%; (2) leaf age: SLA declined between leaf appearance and 10-12 days later then, after a plateau of varying length, it rose again; (3) leaf insertion: SLA of the flag leaf was the most stable with leaf age; (4) plant density: in canopies the final rise in SLA with leaf age occurred earlier than in spaced plants; (5) radiation: SLA declined at approximately 4 cm2 g-1 for each mol quanta m-2 day-1 increase in radiation; (6) genotype: SLA differed among genotypes and the ranking was unchanged by changes in radiation. In two genotypes studied in detail, higher SLA equated with faster leaf area production and larger leaves, but not with chlorophyll content per unit area, stornatal frequency or net CO2 exchange rate per unit area (CER), though it was noted that both SLA and CER changed inversely with leaf aging after the leaf was fully expanded. The importance of SLA in active (positive and negative) and passive roles in plant growth is discussed.
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Pena-Pino, Isabela, Jun Ma, Yusuki Hori, Elena Fomchenko, Kathryn Dusenbery, Margaret Reynolds, Christopher Wilke, et al. "SURG-02. Stereotactic Laser Ablation (SLA) followed by consolidation stereotactic radiosurgery (SRS) as a treatment strategy for brain metastasis that recurred locally after initial radiosurgery (BMRS): a collaborative institutional experience." Neuro-Oncology Advances 3, Supplement_3 (August 1, 2021): iii23. http://dx.doi.org/10.1093/noajnl/vdab071.095.

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Abstract Introduction In independent clinical trials, ~30% of brain metastases recur locally after radiosurgery (BMRS). For these lesions, treatment with stereotactic laser ablation (SLA, also known as laser interstitial thermal therapy (LITT)) alone achieves a 12-month local control (LC12) of 54–85% while repeat SRS achieved LC12 of 54–79%. Here, we report favorable outcomes for BMRS treated with SLA followed by consolidation radiosurgery (SLA/cSRS). Methods Clinical outcome of 18 patients with 19 histologically confirmed BMRS treated with SLA followed by consolidation SRS and &gt;3 months follow-up were collected retrospectively across three institutions. Local control was defined as stability or decrease in contrast-enhancing (CE) and FLAIR volume. Results SLA achieved ablation of 73–100% of the BMRS CE volumes. Consolidation hypo-fractionated radiosurgery (5 Gy x 5 or 6 Gy x 5) was carried out 16–40 days post-SLA (median of 26 days). With a median follow-up of 185 days (range: 93–1367 days) and median overall survival (OS) of 185 days (range: 99–1367 days), 100% LC12 was achieved. 13/18 (72%) patients that required steroid therapy prior to SLA/cSRS were successfully weaned off steroid by three months post-SLA/cSRS. Post-SLA, KPS declined for 3/19 (16%) patients and improved for 1/19 (5%) patients. No KPS changes occurred subsequent to consolidation SRS. There were no 30-day mortalities or wound complications. Two patients required re-admission within 30 days of SRS (severe headache that resolved with steroid therapy (n=1) and new-onset seizure (n=1)). Except for two patients who suffered histologically confirmed, local failure at 649 and 899 days, all other patients are either alive (n=5) or died from systemic disease progression (n=11). None of the treated patients developed symptomatic radiation necrosis. Conclusions This collaborative institutional experience support efficacy and safety of SLA followed by consolidation SRS as a treatment for BMRS. The treatment strategy warrants further investigations.
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Dissertations / Theses on the topic "Sla-6"

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Hu, Rui. "Etude des gènes de classe I non classiques du complexe majeur d'histocompatibilité chez le porc." Versailles-St Quentin en Yvelines, 2011. http://www.theses.fr/2011VERS0013.

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Chez le porc, les trois gènes du CMH de classe I non classiques (gènes SLA-Ib) SLA-6, -7 et -8 sont peu étudiés alors que ce sont des candidats majeurs comme homologues fonctionnels des gènes humains HLA-E, -F et -G qui font l’objet de travaux soutenus de par leur rôle dans la tolérance fœto-maternelle lors de la grossesse chez la femme notamment. Notre objectif a consisté à analyser le polymorphisme, la transcription et l’expression des protéines de ces trois gènes d’intérêt. Nous avons montré que les trois gènes sont transcrits dans une large gamme de tissus, avec une expression prépondérante dans les tissus lymphoïdes, le système digestif et les poumons. Les trois gènes expriment des transcrits qui codent pour des protéines de pleine longueur dont la traduction et la prédiction de conformation sont compatibles avec la présentation de peptides à la surface cellulaire. Les gènes SLA-6 et -7 expriment des transcrits alternatifs qui pourraient coder pour des isoformes solubles, alors qu’un unique transcrit a été trouvé pour le gène SLA-8. Un épissage alternatif dans la région 3’ non codante en aval du codon de terminaison a également été identifié pour SLA-7, suggérant l’existence de mécanismes de régulation post-transcriptionnelle pour ce gène. Les analyses de polymorphisme ont confirmé des variations nucléotidiques limitées mais mis en évidence une variation du nombre de copies du gène SLA-7 selon les animaux. Des analyses sont encore en cours pour caractériser la spécificité d’anticorps monoclonaux dirigés contre les molécules SLA-Ib dans des expériences de transfections transitoires en cultures de cellules. Nos résultats sont une contribution importante à la caractérisation des gènes SLA-Ib chez le porc et permettront de poursuivre avec des approches plus fonctionnelles visant l’analyse de leurs possibles fonctions dans des mécanismes liés à l’immuno-tolérance
In pig, very little information is available on the three non classical MHC class I genes SLA-6, -7 and -8 (SLA-Ib genes). Our aim was to increase knowledge on SLA-Ib genes by studying their polymorphism, transcription and protein expression. Full length transcripts were characterized from thymus and brain of MeLiM pigs resulting in the annotation of 8 exons for SLA-7 and -8 and 7 exons for SLA-6. The three full length cDNAs encode molecules with a predicted folding consistent with peptide presentation. No additional transcript was found for SLA-8 while four and five were detected for SLA-6 and SLA-7, respectively, suggesting that some soluble forms of these molecules may exist. For SLA-7, an alternative spliced variant was found in the 3’UTR of the gene after the termination codon suggesting possible post-transcriptional regulation of the gene. Polymorphism studies confirmed a limited nucleotide polymorphism but revealed an unexpected copy number variation for SLA-7. Ongoing experiments are still in progress to characterize monoclonal antibodies specific of each SLA-Ib molecule in transient transfection systems. Our overall results provided significant new data on SLA-Ib genes and will pave a way toward more functional analyses related to their putative function in immuno-tolerance
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Husain, Syed Farzad. "Evaluation of Methods for 3D Environment Reconstruction with Respect to Navigation and Manipulation Tasks for Mobile Robots." Thesis, Blekinge Tekniska Högskola, Sektionen för ingenjörsvetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-5142.

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The field of 3-D-environment reconstruction has been subject to various research activities in recent years. The applications for mobile robots are manifold. First, for navigation tasks (especially SLAM), the perception of 3-D-obstacles has many advantages over navigation in 2-D-maps, as it is commonly done. Objects that are located hanging above the ground can be recognized and furthermore, the robots gain a lot more information about its operation area what makes localization easier. Second, in the field of tele-operation of robots, a visualization of the environment in three dimensions helps the tele-operator performing tasks. Therefore, a consistent, dynamically updated environment model is crucial. Third, for mobile manipulation in a dynamic environment, an on-line obstacle detection and collision avoidance can be realized, if the environment is known. In recent research activities, various approaches to 3-D-environment reconstruction have evolved. Two of the most promising methods are FastSLAM and 6-D-SLAM. Both are capable of building dense 3D environment maps on-line. The first one uses a Particle Filter applied on extracted features in combination with a robot system model and a measurement model to reconstruct a map. The second one works on 3-D point cloud data and reconstructs an environment using the ICP algorithm. Both of these methods are implemented in GNU C++. Firstly, FastSLAM is implemented. The object-oriented programming technique is used to build up the Particle and Extended Kalman Filters. Secondly, 6-D SLAM is implemented. The concept of inheritance in C++ is used to make the implementation of ICP algorithm as much generic as possible. To test our implementation a mobile robot called Care-O-bot 3 is used. The mobile robot is equipped with a color and a time-of-fight camera. Data sets are taken as the robot moves in different environments and our implementation of FastSLAM and 6-D SLAM is used to reconstruct the maps.
Fältet av 3-D-miljö återuppbyggnaden har varit föremål för olika forskningsinsatser under senare år. De ansökningar om mobila robotar är många. Först för navigering uppgifter (särskilt Slam), uppfattningen av 3-D-hinder har många fördelar jämfört navigering i 2-D-kartor, som det vanligtvis görs. Objekt som finns hänger över marken kan erkännas och dessutom robotarna vinna mycket mer information om dess verksamhet området vad som gör lokalisering lättare. För det andra, när det gäller tele-drift av robotar, hjälper en visualisering av miljön i tre dimensioner tele-aktör som utför uppgifter. Därför är en konsekvent, dynamiskt uppdaterade miljö modell avgörande. Tredje kan för mobila manipulation i en dynamisk miljö, en on-line hinder upptäcka och undvika kollisioner förverkligas, om miljön är känd. Under senare forskning, till 3-D-miljö återuppbyggnaden olika strategier har utvecklats. Två av de mest lovande metoderna är FastSLAM och 6-D-Slam. Båda kan bygga täta 3D-miljö kartor on-line. Det första man använder ett partikelfilter som tillämpas på extraherade funktioner i kombination med ett robotsystem modell och en mätning modell för att rekonstruera en karta. Den andra verk på 3-D data punktmoln och rekonstruerar en miljö med hjälp av ICP algoritm. Båda dessa metoder implementeras i GNU C. För det första är FastSLAM genomföras. Det objektorienterade programmering Tekniken används för att bygga upp Partikel-och Extended Kalman filter. För det andra är 6-D SLAM genomförs. Begreppet arv i C används för att göra genomförandet av ICP algoritm så mycket generisk som möjligt. För att testa vårt genomförande en mobil robot som heter Care-O-bot 3 används. Den mobila roboten är utrustad med en färg och en time-of-kamp kamera. Dataset tas som roboten rör sig i olika miljöer och vårt genomförande av FastSLAM och 6-D SLAM används för att rekonstruera kartorna.
farzadhusain@gmail.com Contact in Sweden 0046-762-409910
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Joelsson, Klara. "-S morphemes in L2 English : An investigation into student essays in grades 6, 9, and 12 in Sweden." Thesis, Mälardalens högskola, Akademin för utbildning, kultur och kommunikation, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-38572.

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Swedish students’ morpheme acquisition order in English, including the acquisition of -s morphemes, is a relatively unstudied topic. Given the morphological differences between the English and Swedish languages, students learning English in Sweden may encounter difficulties in the use of the third person singular present tense -s morpheme. Research also shows that Swedish students use the plural -s morpheme rather accurately at 9-10 years old. Mapping out the usage of the -s morphemes may pave the way for understanding the difficulties learners encounter in the use of such morphemes. Furthermore, looking into the usage of morphemes that have the same form but different grammatical functions (e.g.,-s morphemes) may help us understand the relationship between different proficiency levels and the accuracy rate of morpheme usage in L2 English. To this end, this study investigates a corpus of texts produced by students learning English in Sweden in grades 6, 9 and 12. The focus is particularly on the frequency and accuracy of the use of -s morphemes, aiming at revealing which type of -s morphemes has a higher accuracy rate. The results show that the accuracy rate with the plural -s morpheme is relatively higher, whereas the possessive -‘s morpheme is the most problematic one across all levels. Additionally, the largest issue with the contracted verb form of be -‘s was that the students did not add an apostrophe between the word and the -s, rather than not using the form at all. Lastly, the third person singular present tense-s accuracy was very low in grade 6 but increased a lot through grade 9 and 12 where more complex subjects were the largest issue. However, the results indicate that further research with a larger corpus size is required to be able to generalize the findings.
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Kloß, Anja. "Einfluss von klarzelligen Nierenkarzinomzellen auf die immunmodulatorischen Fähigkeiten von humanen 6-sulfo LacNAc+ dendritischen Zellen." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-178387.

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Nierenzellkarzinome (NZKs) gelten als stark immunogene Tumore. Dies ist insbesondere auf die Infiltration durch verschiedene Immunzellpopulationen, wie T-Lymphozyten und Natürliche Killer (NK)-Zellen, sowie das klinische Ansprechen auf immuntherapeutische Strategien zurückzuführen. Bisher existieren jedoch nur sehr wenige Studien zur Rolle von humanen nativen dendritischen Zellen (DCs) in NZK-Geweben und über die Tumor-vermittelte Modulation dieser DCs. DCs nehmen als professionelle Antigen-präsentierende Zellen eine zentrale Schlüsselrolle bei der Induktion und Aufrechterhaltung der angeborenen sowie adaptiven Immunantwort ein. Daher wurde im Rahmen dieser Arbeit erstmals der Effekt von klarzelligen NZKs auf den Phänotyp sowie die immunmodulatorischen Fähigkeiten von 6-sulfo LacNAc+ (slan)DCs evaluiert. SlanDCs, welche eine große Subpopulation humaner Blut-DCs darstellen, sind neben der Sekretion großer Mengen proinflammatorischer Zytokine dazu befähigt, Tumorzellen direkt zu lysieren. Des Weiteren sind slanDCs in der Lage, die antitumoralen Effekte von NK-Zellen zu fördern und CD4+ T-Helfer-Zellen sowie Tumor-reaktive CD8+ T-Lymphozyten effizient zu stimulieren. Angesichts dieser proinflammatorischen Eigenschaften können slanDCs wesentlich an einer Tumor-gerichteten Immunantwort beteiligt sein. Auf dieser Grundlage erfolgte im Rahmen der vorliegenden Arbeit der immunhistochemische Nachweis von slanDCs in klarzelligen NZK-Geweben. Im Vergleich zu Tumor-freiem Nierengewebe trat in den primären Tumorgeweben eine erhöhte Zahl infiltrierender slanDCs auf. Zudem wurde die Präsenz von slanDCs in Lymphknoten- sowie Fernmetastasen von NZK-Patienten beobachtet. Weiterführende Untersuchungen an frischen klarzelligen NZK-Geweben demonstrierten, dass NZK-infiltrierende slanDCs einen unreifen Phänotyp ausprägen und Interleukin-10 produzieren. Ausgehend von diesen Erkenntnissen erfolgten funktionelle Analysen, bei denen der Einfluss der kommerziell erhältlichen klarzelligen NZK-Linien ACHN und Caki-1 sowie der primären klarzelligen NZK-Linien MZ1257RC und MZ2877RC auf bedeutende immunmodulatorische Fähigkeiten von slanDCs untersucht wurde. In diesem Zusammenhang zeigte sich, dass NZK-Zellen effektiv in der Lage sind, sowohl die slanDC-vermittelte Proliferation von CD4+ und CD8+ T-Lymphozyten, als auch die slanDC-induzierte Differenzierung naïver CD4+ T-Lymphozyten in proinflammatorische T-Helfer 1-Zellen zu inhibieren. Darüber hinaus wurde demonstriert, dass NZK-Zellen das Potenzial von slanDCs zur Aktivierung von NK-Zellen hemmen. Untersuchungen der zugrunde liegenden Mechanismen zeigten, dass die funktionelle Inhibition von slanDCs durch klarzellige NZK-Zellen über membranständige Moleküle vermittelt wird. Die im Rahmen dieser Dissertation gewonnenen Erkenntnisse weisen darauf hin, dass NZKs die Ausreifung sowie wesentliche funktionelle Eigenschaften von DCs inhibieren. Dies deutet auf einen neuen Immunescape-Mechanismus klarzelliger NZKs hin, welcher auf einer Tumorzell-vermittelten Generierung von tolerogenen slanDCs basiert und eine unzureichende Aktivierung der angeborenen sowie adaptiven Tumor-gerichteten Immunantwort zur Folge hat. Diese neuen Erkenntnisse können einen Beitrag zu einem besseren Verständnis der Interaktion von NZKs mit nativen humanen DCs leisten und die Konzeption neuer therapeutischer Strategien ermöglichen, welche auf einer Verstärkung der antitumoralen Eigenschaften von DCs beruhen.
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Weiskopf, Daniela. "Stabilität und laterale Mobilität von porenüberspannenden Membranen auf porösen Siliziumsubstraten." Doctoral thesis, 2009. http://hdl.handle.net/11858/00-1735-0000-0006-B4BB-6.

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Millé, Aline Noel. "Einfluss des Transkriptionsfaktors B-cell lymphoma 6 (BCL6) auf die Expression renaler Transportproteine." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-002B-7C49-1.

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Books on the topic "Sla-6"

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Ireland grand slam champions: RBS 6 Nations, 2009. Dublin, Ireland: Nonsuch, 2009.

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Lyons, Jim. Ireland grand slam champions: RBS 6 Nations, 2009. Dublin, Ireland: Nonsuch, 2009.

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SLE 2009 (2009 Denver, Colo.). Software language engineering: Second international conference, SLE 2009, Denver, CO, USA, October 5-6, 2009 : revised selected papers. Berlin: Springer, 2010.

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Board, United States National Transportation Safety. Inadvertent in-flight slat deployment: China Eastern Airlines flight 583, McDonnell Douglas MD-11, B-2171, 950 nautical miles south of Shemya, Alaska April 6, 1993. Washington, D.C: The Board, 1994.

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United States. National Transportation Safety Board. Inadvertent in-flight slat deployment: China Eastern Airlines flight 583, McDonnell Douglas MD-11, B-2171, 950 nautical miles south of Shemya, Alaska April 6, 1993. Washington, D.C: The Board, 1994.

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Hawaii. Department of Public Safety. Department of Public Safety report to the 2011 legislature: Act 100, Sections 6 and 7, Session Laws of Hawaii 1999, requiring all departments and agencies to identify their goals and objectives in accordance to Act 100, SLH 1999. Honolulu, Hawaii: Department of Public Safety, 2010.

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Hilden, Jon. Accident Investigation (1-SLA-6). J J Keller & Associates, 1996.

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Brimsek, Tobi A. Inside Information: Profiles of Association Libraries and Information Centers (Sla Research Series, No. 6). Special Libraries Assn, 1991.

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Vi r"escontr ant"ernassional d"e studi an sla lenga e la literatura piemontèisa, Alba 6 - 7 magg 1989. Alba: Famija Albeìsa, 1990.

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Inoue, Takehiko. Slam Dunk, tome 6. Kana, 2000.

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Book chapters on the topic "Sla-6"

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Robinson, Peter. "6. Learning conditions, aptitude complexes, and SLA." In Language Learning & Language Teaching, 113–33. Amsterdam: John Benjamins Publishing Company, 2002. http://dx.doi.org/10.1075/lllt.2.08rob.

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Tracy-Ventura, Nicole, and Amanda Huensch. "Chapter 6. The potential of publicly shared longitudinal learner corpora in SLA research." In Language Learning & Language Teaching, 149–70. Amsterdam: John Benjamins Publishing Company, 2018. http://dx.doi.org/10.1075/lllt.51.07tra.

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Kahoul, Walid, Anne Vainikka, and Martha Young-Scholten. "6. The Mystery of the Missing Inflections." In Mind Matters in SLA, edited by Clare Wright, Thorsten Piske, and Martha Young-Scholten, 93–116. Bristol, Blue Ridge Summit: Multilingual Matters, 2018. http://dx.doi.org/10.21832/9781788921626-008.

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Stephenson, John. "6. Learner Attitudes Towards Comprehension-based Language Learning." In Input Matters in SLA, edited by Thorsten Piske and Martha Young-Scholten, 116–36. Bristol, Blue Ridge Summit: Multilingual Matters, 2008. http://dx.doi.org/10.21832/9781847691118-009.

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Gregersen, Tammy, Peter D. MacIntyre, and Margarita Meza. "6 Positive Psychology Exercises Build Social Capital for Language Learners: Preliminary Evidence." In Positive Psychology in SLA, edited by Peter D. MacIntyre, Tammy Gregersen, and Sarah Mercer, 147–67. Bristol, Blue Ridge Summit: Multilingual Matters, 2016. http://dx.doi.org/10.21832/9781783095360-007.

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Hall, Joan Kelly. "L2 Learning Is Mediated by Learners’ Social Identities." In Essentials of SLA for L2 Teachers, 95–108. New York, NY: Routledge, [2018]: Routledge, 2018. http://dx.doi.org/10.4324/9781315181271-6.

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Ekiert, Monika. "Chapter 6: Linguistic Effects on Thinking for Writing: The Case of Articles in L2 English." In Linguistic Relativity in SLA, edited by ZhaoHong Han and Teresa Cadierno, 125–53. Bristol, Blue Ridge Summit: Multilingual Matters, 2010. http://dx.doi.org/10.21832/9781847692788-008.

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Hemmi, Chantal. "6. Dual Identities Perceived by Bilinguals." In Multiple Perspectives on the Self in SLA, edited by Sarah Mercer and Marion Williams, 75–91. Bristol, Blue Ridge Summit: Multilingual Matters, 2014. http://dx.doi.org/10.21832/9781783091362-007.

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Mystkowska-Wiertelak, A. "Chapter 6. The Development of Implicit Knowledge through Structured Input Activities: The Importance of Individual Perceptions Concerning Grammar Instruction." In Individual Learner Differences in SLA, edited by Janusz Arabski and Adam Wojtaszek, 95–109. Bristol, Blue Ridge Summit: Multilingual Matters, 2011. http://dx.doi.org/10.21832/9781847694355-008.

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Whyatt, Bogusława. "Chapter 6. Bilingual Language Control in Translation Tasks: A TAP Study into Mental Effort Management by Inexperienced Translators." In Neurolinguistic and Psycholinguistic Perspectives on SLA, edited by Janusz Arabski and Adam Wojtaszek, 79–92. Bristol, Blue Ridge Summit: Multilingual Matters, 2009. http://dx.doi.org/10.21832/9781847692429-008.

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Conference papers on the topic "Sla-6"

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Xiong, Kaiqi, and Harry Perros. "QRP01-6: Resource Optimization Subject to a Percentile Response Time SLA for Enterprise Computing." In IEEE Globecom 2006. IEEE, 2006. http://dx.doi.org/10.1109/glocom.2006.423.

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Kai Shi, Feng Feng, George S. D. Gordon, Timothy D. Wilkinson, and Benn C. Thomsen. "SLM-based mode division multiplexing system with 6×6 sparse equalization." In 2015 IEEE Photonics Conference (IPC). IEEE, 2015. http://dx.doi.org/10.1109/ipcon.2015.7323695.

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WORLEY, G., and W. FROST. "Winds, turbulence, and diffusion at SLC-6." In Shuttle Environment and Operations II Conference. Reston, Virigina: American Institute of Aeronautics and Astronautics, 1985. http://dx.doi.org/10.2514/6.1985-7043.

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Reiseter, S., Ø. Molberg, R. Gunnarsson, and K. Lerang. "S1A:6 Mctd and sle: similarities and differences." In 11th European Lupus Meeting, Düsseldorf, Germany, 21–24 March 2018, Abstract presentations. Lupus Foundation of America, 2018. http://dx.doi.org/10.1136/lupus-2018-abstract.3.

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Rustin, M. H. A., H. A. Bull, P. M. Dowd, D. A. Isenberg, M. L. Snaith, and S. J. Machin. "PRESENCE OF THE LUPUS ANTICOAGULANT IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS DOES NOT CAUSE INHIBITION OF PROSTACYCLIN PRODUCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644227.

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The cause of the thrombotic tendency in patients having the lupus anticoagulant (LA) is unknown. Since inhibition of prostacyclin production by endothelial cells (EC) may be a pathogenetic factor, the effect of sera from normal subjects (NS, n=9), SLE (systemic lupus erythematosus) + LA (n=9) and SLE-LA (n=13) on the production of PGI2 by cultured human EC was studied.Confluent 1° cultures of human umbilical vein EC were incubated with 1, 5, 10 and 20% sera from the above for 24 hours. After stimulation with thecalcium ionophore A23187, 6-keto-PGF1α(the stable metabolite of PGI2) in the supernatant was measured by radioimmunoassay.A dose dependent inhibition of 6-keto-PGF1α was observed with all the sera but only the 10 and 20% sera from patients with SLE-LA produced a significantly greater inhibition than control sera. The mean production of 6-keto-PGFia (ng/104 cells) was 2.278 (NS), 2.6594 (SLE-LA) and 2.1418 (SLE + LA)after incubation with 1% sera for 24 hours. This decreased to 1.3647, 0.6517 and 0.942 respectively following incubation with 20% sera. This represented a 44% (NS), 71% (SLE-LA) and 62% (SLE + LA) inhibition of 6-keto-PGF1α production compared to serum free media.The non-significant reduction in prostacyclin production by sera from patients with SLE and the lupus anticoagulant suggests that other factors are responsible for the thrombotic tendency in these patients.
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Singh, Balbir, Ee Loon Tan, Zhu Pan, Olivia Mirza, and Youtam Mamo. "Experimental Analysis of Composite Push Test Integrating Geopolymer Concrete." In 12th international conference on ‘Advances in Steel-Concrete Composite Structures’ - ASCCS 2018. Valencia: Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/asccs2018.2018.7278.

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This paper primarily focuses on implementing constructions practises that are sustainable, and that can also meet the current demand for infrastructure development around the world. The cement industry is one of the largest industries in the world, as result current construction practices are causing adverse environmental issues ranging from the excessive utilisation of natural resources, emission of greenhouse gases and producing an excessive amount of waste. Thus, to tackle the problem one encouraging solution is to use alkali activated Geopolymer concrete that utilises waste product such as fly ash and grounded slag as a 100% replacement of Portland cement. Subsequently, this paper presents experimental testing and discusses the behaviour of six (6) steel-concrete composite push test specimens incorporating Geopolymer concrete and OPC concrete. A total of three (3) specimens were fabricated using steel profiled Bondek Sheeting and remaining three (3) specimens had a conventional concrete slab. From the result obtained, it was found that push test specimen with conventional slab outperformed specimens fabricated with Bondek profile sheeting due to the reduced amount of concrete surrounding the shear studs cause by Bondek flanges. Also, the results showed that geopolymer concrete has great potential as it achieved almost identical results as compared to control OPC push test specimens.
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Frese, Udo. "Efficient 6-DOF SLAM with Treemap as a Generic Backend." In 2007 IEEE International Conference on Robotics and Automation. IEEE, 2007. http://dx.doi.org/10.1109/robot.2007.364221.

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Aulinas, J., Xavier Lladó, J. Salvi, and Y. R. Petillot. "Selective Submap Joining for underwater large scale 6-DOF SLAM." In 2010 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2010). IEEE, 2010. http://dx.doi.org/10.1109/iros.2010.5650438.

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Hao, Yan, Li Changchun, Liu Xiaodong, Zhang Jinying, and Hu Huajun. "Track slab fine adjustment system based on 6-DOF parallel mechanism." In 2011 IEEE 5th International Conference on Robotics, Automation and Mechatronics (RAM). IEEE, 2011. http://dx.doi.org/10.1109/ramech.2011.6070454.

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Huang, Wei, Yinguo Li, and Fangchao Hu. "Real-Time 6-DOF Monocular Visual SLAM based on ORB-SLAM2." In 2019 Chinese Control And Decision Conference (CCDC). IEEE, 2019. http://dx.doi.org/10.1109/ccdc.2019.8833084.

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Reports on the topic "Sla-6"

1

Brent Isaacson, Mike Slepian, and Thomas Richter. AISI/DOE Advanced Process Control Program Vol. 3 of 6: Improved Liquid Steel Feeding for Slab Casters. Office of Scientific and Technical Information (OSTI), June 1999. http://dx.doi.org/10.2172/795001.

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Clausen, Jay, D. Moore, L. Cain, and K. Malinowski. VI preferential pathways : rule or exception. Engineer Research and Development Center (U.S.), July 2021. http://dx.doi.org/10.21079/11681/41305.

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Trichloroethylene (TCE) releases from leaks and spills next to a large government building occurred over several decades with the most recent event occurring 20 years ago. In response to a perceived conventional vapor intrusion (VI) issue a sub-slab depressurization system (SSDS) was installed 6 years ago. The SSDS is operating within design limits and has achieved building TCE vapor concentration reductions. However, subsequent periodic TCE vapor spikes based on daily HAPSITE™ measurements indicate additional source(s). Two rounds of smoke tests conducted in 2017 and 2018 involved introduction of smoke into a sanitary sewer and storm drain manholes located on effluent lines coming from the building until smoke was observed exiting system vents on the roof. Smoke testing revealed many leaks in both the storm sewer and sanitary sewer systems within the building. Sleuthing of the VI source term using a portable HAPSITE™ indicate elevated vapor TCE levels correspond with observed smoke emanation from utility lines. In some instances, smoke odors were perceived but no leak or suspect pipe was identified suggesting the odor originates from an unidentified pipe located behind or enclosed in a wall. Sleuthing activities also found building roof materials explain some of the elevated TCE levels on the 2nd floor. A relationship was found between TCE concentrations in the roof truss area, plenum space above 2nd floor offices, and breathing zone of 2nd floor offices. Installation of an external blower in the roof truss space has greatly reduced TCE levels in the plenum and office spaces. Preferential VI pathways and unexpected source terms may be overlooked mechanisms as compared to conventional VI.
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Een heldere ecosysteemdienstentaal : Natuurrapport - Aan de slag met ecosysteemdiensten Technisch rapport - Hoodstuk 6. Instituut voor Natuur- en Bosonderzoek, 2016. http://dx.doi.org/10.21436/inbor.12342954.

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