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1

Poppenga, R. H. "Slaframine intoxication." Equine Veterinary Education 24, no. 6 (2011): 284–85. http://dx.doi.org/10.1111/j.2042-3292.2011.00349.x.

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2

Cossy, Janine, Catherine Willis, Véronique Bellosta, and Laurent Saint-Jalmes. "Enantioselective Allyltitanation. Synthesis of (-)-Slaframine." Synthesis 2002, no. 07 (2002): 951–57. http://dx.doi.org/10.1055/s-2002-28505.

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3

Choi, Jong-Ryoo, Shin Han, and Jin K. Cha. "An enantioselective synthesis of (−)-slaframine." Tetrahedron Letters 32, no. 45 (1991): 6469–72. http://dx.doi.org/10.1016/0040-4039(91)80195-c.

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4

WASSERMAN, H. H., and C. B. VU. "ChemInform Abstract: The Chemistry of Vicinal Tricarbonyls. A Synthesis of (.+-.)- Slaframine and (.+-.)-6-epi-Slaframine." ChemInform 26, no. 19 (2010): no. http://dx.doi.org/10.1002/chin.199519219.

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5

Pearson, William H., Stephen C. Bergmeier, and John P. Williams. "Synthesis of (-)-slaframine and related indolizidines." Journal of Organic Chemistry 57, no. 14 (1992): 3977–87. http://dx.doi.org/10.1021/jo00040a045.

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6

Broquist, Harry P. "Slaframine and Swainsonine, Mycotoxins from Rhizoctonia Leguminicola." Journal of Toxicology: Toxin Reviews 5, no. 2 (1986): 241–52. http://dx.doi.org/10.3109/15569548609012719.

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7

Cossy, Janine, Catherine Willis, Veronique Bellosta, and Laurent Saint-Jalmes. "ChemInform Abstract: Enantioselective Allyltitanation. Synthesis of (-)-Slaframine." ChemInform 33, no. 39 (2010): no. http://dx.doi.org/10.1002/chin.200239211.

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8

Knapp, Spencer, and Frank S. Gibson. "Radical routes to indolizidines. Synthesis of (-)-slaframine." Journal of Organic Chemistry 57, no. 18 (1992): 4802–9. http://dx.doi.org/10.1021/jo00044a011.

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9

Pearson, William H., and Stephen C. Bergmeier. "A synthesis of (-)-slaframine and (-)-1,8a-diepislaframine." Journal of Organic Chemistry 56, no. 6 (1991): 1976–78. http://dx.doi.org/10.1021/jo00006a002.

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10

Borges, A. S., J. P. Oliveira-Filho, J. J. Simon, M. I. P. Palumbo, and P. M. Imerman. "Slaframine toxicosis in Brazilian horses causing excessive salivation." Equine Veterinary Education 24, no. 6 (2011): 279–83. http://dx.doi.org/10.1111/j.2042-3292.2011.00275.x.

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11

Kelly, J. M., B. W. McBride, M. A. Froetschel, W. J. Croom Jr., and W. M. Hagler Jr. "Effects of a parasympathomimetic agent, slaframine, on reticulo-omasal orifice function." Canadian Journal of Animal Science 71, no. 2 (1991): 321–26. http://dx.doi.org/10.4141/cjas91-041.

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Three nonlactating, nonpregnant, ruminally cannulated Holstein cows (680–732 kg) fed chopped brome hay ad libitum once daily were used to study effects of slaframine (SF) on rumen function in a 3 × 3 Latin square design. Animals were injected intramuscularly with 0, 20 or 40 μg kg BW−1 SF, allowing for 1 d between trials. At 0, 40, 180 and 360 min postinjection rumen contents were partially evacuated. Reticular contraction frequency (RCF) was determined using a balloon placed in the reticulum connected to a pressure transducer and physiograph and reticulo-omasal orifice opening duration (ROOD)
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12

Comins, Daniel L., and Alan B. Fulp. "EnantiopureN-Acyldihydropyridones as Synthetic Intermediates: Asymmetric Synthesis of (−)-Slaframine." Organic Letters 1, no. 12 (1999): 1941–43. http://dx.doi.org/10.1021/ol991083v.

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13

KNAPP, S., and F. S. GIBSON. "ChemInform Abstract: Radical Routes to Indolizidines. Synthesis of (-)-Slaframine." ChemInform 24, no. 5 (2010): no. http://dx.doi.org/10.1002/chin.199305280.

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14

Knight, David W., and A. William Sibley. "Total synthesis of (−)-slaframine from (2R,3S)-3-hydroxyproline." Journal of the Chemical Society, Perkin Transactions 1, no. 15 (1997): 2179–88. http://dx.doi.org/10.1039/a701878i.

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15

Szeto, Peter, David C. Lathbury, and Timothy Gallagher. "Heterocyclic ketones as pre-formed building blocks. Synthesis of (−)-slaframine." Tetrahedron Letters 36, no. 38 (1995): 6957–60. http://dx.doi.org/10.1016/0040-4039(95)01379-v.

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16

Broquist, H. P. "The Indolizidine Alkaloids, Slaframine and Swainsonine: Contaminants in Animal Forages." Annual Review of Nutrition 5, no. 1 (1985): 391–409. http://dx.doi.org/10.1146/annurev.nu.05.070185.002135.

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17

Szeto, P. "Heterocyclic ketones as pre-formed building blocks. Synthesis of (−)-slaframine." Tetrahedron Letters 36, no. 38 (1995): 6957–60. http://dx.doi.org/10.1016/00404-0399(50)1379v-.

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18

Walker, J. A., C. R. Krehbiel, D. L. Harmon, G. St. Jean, W. J. Croom Jr., and W. M. Hagler Jr. "Effects of slaframine and 4-diphenylacetoxy-N-methylpiperidine methiodide (4DAMP) on pancreatic exocrine secretion in the bovine." Canadian Journal of Physiology and Pharmacology 72, no. 1 (1994): 39–44. http://dx.doi.org/10.1139/y94-007.

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Three Holstein steers (345 ± 22 kg) surgically fitted with a pancreatic cannula were used in two 3 × 3 Latin square design experiments to examine the effects of slaframine (SF), a muscarinic agonist, or 4-diphenylacetoxy-N-methylpiperidine methiodide (4DAMP), an M3 muscarinic glandular receptor antagonist, on pancreatic exocrine secretion. Pancreatic exocrine secretion was collected for 8 h postdosing at 30-min intervals beginning 1 h postfeeding. In experiment 1, steers were dosed with 0, 25, or 50 μg∙kg−1 body weight (BW) of SF. Secretion of pancreatic juice and the pH of the secreted juice
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19

Croom, W. J., W. M. Hagler, M. A. Froetschel, and A. D. Johnson. "The involvement of slaframine and swainsonine in slobbers syndrome: a review." Journal of Animal Science 73, no. 5 (1995): 1499–508. http://dx.doi.org/10.2527/1995.7351499x.

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20

SZETO, P., D. C. LATHBURY, and T. GALLAGHER. "ChemInform Abstract: Heterocyclic Ketones as Preformed Building Blocks. Synthesis of (-)- Slaframine." ChemInform 27, no. 1 (2010): no. http://dx.doi.org/10.1002/chin.199601250.

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21

KNIGHT, D. W., and A. W. SIBLEY. "ChemInform Abstract: Total Synthesis of (-)-Slaframine from (2R,3S)-3-Hydroxyproline." ChemInform 28, no. 49 (2010): no. http://dx.doi.org/10.1002/chin.199749241.

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22

Knight, David W., and A. William Sibley. "A total synthesis of (−)-slaframine from (+)-cis-(2R,3S)-3-hydroxyproline." Tetrahedron Letters 34, no. 41 (1993): 6607–10. http://dx.doi.org/10.1016/0040-4039(93)88117-2.

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23

Carretero, Juan C. "Stereodivergent Synthesis of (-)- and (+)-Slaframine from γ-Hydroxy-α,β-unsaturated Sulfones". Synlett 1999, № 1 (1999): 49–52. http://dx.doi.org/10.1055/s-1999-2546.

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24

Sibi, Mukund P., James W. Christensen, Biqin Li, and Paul A. Renhowe. "A novel thermolytic annulation of an oxazolidinone: an enantiospecific synthesis of (-)-slaframine." Journal of Organic Chemistry 57, no. 16 (1992): 4329–30. http://dx.doi.org/10.1021/jo00042a002.

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25

FROETSCHEL, M. A., W. M. HAGLER, W. J. CROOM, et al. "Research Note: Effects of Slaframine on Circulating Concentrations of Growth Hormone and Glucose." Poultry Science 66, no. 5 (1987): 904–6. http://dx.doi.org/10.3382/ps.0660904.

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26

Froetschel, M. A., W. J. Croom, W. M. Hagler, R. Argenzio, J. Liacos, and H. P. Broquist. "Effects of Slaframine on Ruminant Digestive Function: Ruminal Motility in Sheep and Cattle." Journal of Animal Science 63, no. 5 (1986): 1502–8. http://dx.doi.org/10.2527/jas1986.6351502x.

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27

Froetschel, M. A., M. N. Streeter, H. E. Amos, W. J. Croom Jr., and W. M. Hagler Jr. "Effects of abomasal slaframine infusion on ruminal digesta passage and digestion in steers." Canadian Journal of Animal Science 75, no. 1 (1995): 157–63. http://dx.doi.org/10.4141/cjas95-021.

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Slaframine was infused intra-abomasally once daily 3 h after feeding to four ruminally and abomasally cannulated Jersey steers (586 ± 88.6 kg) at 0 (saline control), 10, 20, or 30 μg kg−1 BW in a 4 × 4 Latin square design experiment. Periods were 14 d in length. On a DM basis, diets were a 38:62, sorghum silage: concentrate offered at 125% of the net energy required for maintenance. Ruminal, abomasal, and fecal samples were collected at 2-h intervals on days 10–12, and ruminal contents were completely evacuated and sampled at 3, 6, 12, and 24 h after feeding on days 13 and 14. Ruminal volume a
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28

KNIGHT, D. W., and W. SIBLEY. "ChemInform Abstract: A Total Synthesis of (-)-Slaframine from (+)-cis-(2R,3S)-3- Hydroxyproline." ChemInform 25, no. 17 (2010): no. http://dx.doi.org/10.1002/chin.199417244.

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29

Pourashraf, Mehrnaz, Philippe Delair, Martin O. Rasmussen, and Andrew E. Greene. "Highly Enantioselective Approach to Indolizidines: Preparation of (+)-(1S,8aS)-1-Hydroxyindolizidine and (−)-Slaframine†." Journal of Organic Chemistry 65, no. 21 (2000): 6966–72. http://dx.doi.org/10.1021/jo0005621.

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30

Gaskins, H. R., W. J. Croom, J. M. Fernandez, J. E. van Eys, W. M. Hagler, and W. L. Johnson. "Metabolic responses to protein supplementation and slaframine in goats and sheep fed roughage." Small Ruminant Research 6, no. 1-2 (1991): 73–84. http://dx.doi.org/10.1016/0921-4488(91)90010-n.

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31

FROETSCHEL, M. A., W. M. HAGLER, W. J. CROOM, J. ORT, and H. P. BROQUIST. "Effects of Chronic Administration of Slaframine on Production and Digestive Function in Broiler Chicks." Poultry Science 66, no. 2 (1987): 357–62. http://dx.doi.org/10.3382/ps.0660357.

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32

Froetschel, M. A., W. J. Croom, W. M. Hagler, L. P. Tate, and H. P. Broquist. "Effects of Slaframine on Ruminant Digestive Function: Resting Salivary Flow and Composition in Cattle." Journal of Animal Science 62, no. 5 (1986): 1404–11. http://dx.doi.org/10.2527/jas1986.6251404x.

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33

Jacques, K., D. L. Harmon, W. J. Croom, and W. M. Hagler. "Estimating Salivary Flow and Ruminal Water Balance of Intake, Diet, Feeding Pattern, and Slaframine." Journal of Dairy Science 72, no. 2 (1989): 443–52. http://dx.doi.org/10.3168/jds.s0022-0302(89)79126-8.

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34

Carretero, Juan C., та Ramon Gomez Arrayas. "ChemInform Abstract: Stereodivergent Synthesis of (-)- and (+)-Slaframine from γ-Hydroxy-α,β-Unsaturated Sulfones." ChemInform 30, № 20 (2010): no. http://dx.doi.org/10.1002/chin.199920200.

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35

SIBI, M. P., J. W. CHRISTENSEN, B. LI, and P. A. RENHOWE. "ChemInform Abstract: A Novel Thermolytic Annulation of an Oxazolidinone: An Enantiospecific Synthesis of (-)-Slaframine." ChemInform 23, no. 51 (1992): no. http://dx.doi.org/10.1002/chin.199251287.

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36

Chapa, A. M., J. M. Fernandez, D. L. Thompson, et al. "Endocrine and metabolic response to muscarinic stimulation and inhibition in the ruminant: effects of slaframine." Journal of Animal Science 73, no. 12 (1995): 3673. http://dx.doi.org/10.2527/1995.73123673x.

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37

Takahata, Hiroki, Yasunori Banba, and Takefumi Momose. "Asymmetric synthesis of 1-hydroxyindolizidines, biosynthetic precursors to the toxic indolizidine alkaloids slaframine and swainsonine." Tetrahedron: Asymmetry 1, no. 11 (1990): 763–64. http://dx.doi.org/10.1016/s0957-4166(00)80439-5.

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38

Pourashraf, Mehrnaz, Philippe Delair, Martin O. Rasmussen, and Andrew E. Greene. "ChemInform Abstract: Highly Enantioselective Approach to Indolizidines: Preparation of (+)-(1S,8aS)-1-Hydroxyindolizidine and (-)-Slaframine." ChemInform 32, no. 10 (2001): no. http://dx.doi.org/10.1002/chin.200110220.

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39

Hibbard, Beth, James P. Peters, S. Theodore Chester, et al. "The effect of slaframine on salivary output and subacute and acute acidosis in growing beef steers2." Journal of Animal Science 73, no. 2 (1995): 516–25. http://dx.doi.org/10.2527/1995.732516x.

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40

Imerman, P. M., and H. M. Stahr. "New, sensitive high-performance liquid chromatography method for the determination of slaframine in plasma and milk." Journal of Chromatography A 815, no. 1 (1998): 141–45. http://dx.doi.org/10.1016/s0021-9673(98)00029-6.

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41

Bird, A. R., W. J. Croom, J. V. Bailey, et al. "Tropical pasture hay utilization with slaframine and cottonseed meal: ruminal characteristics and digesta passage in wethers1." Journal of Animal Science 71, no. 6 (1993): 1634–40. http://dx.doi.org/10.2527/1993.7161634x.

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42

Harris, Constance M., Marilyn J. Schneider, Frank S. Ungemach, James E. Hill, and Thomas M. Harris. "Biosynthesis of the toxic indolizidine alkaloids slaframine and swainsonine in Rhizoctonia leguminicola: metabolism of 1-hydroxyindolizidines." Journal of the American Chemical Society 110, no. 3 (1988): 940–49. http://dx.doi.org/10.1021/ja00211a039.

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43

Harris, Thomas M., Constance M. Harris, James E. Hill, Frank S. Ungemach, Harry P. Broquist, and Brian M. Wickwire. "(1S,2R,8aS)-1,2-Dihydroxyindolizidine formation by Rhizoctonia leguminicola, the fungus that produces slaframine and swainsonine." Journal of Organic Chemistry 52, no. 14 (1987): 3094–98. http://dx.doi.org/10.1021/jo00390a024.

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44

Naranjo, Leopoldo, Eva Martín de Valmaseda, Javier Casqueiro та ін. "Inactivation of the lys7 Gene, Encoding Saccharopine Reductase in Penicillium chrysogenum, Leads to Accumulation of the Secondary Metabolite Precursors Piperideine-6-Carboxylic Acid and Pipecolic Acid from α-Aminoadipic Acid". Applied and Environmental Microbiology 70, № 2 (2004): 1031–39. http://dx.doi.org/10.1128/aem.70.2.1031-1039.2004.

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ABSTRACT Pipecolic acid serves as a precursor of the biosynthesis of the alkaloids slaframine and swainsonine (an antitumor agent) in some fungi. It is not known whether other fungi are able to synthesize pipecolic acid. Penicillium chrysogenum has a very active α-aminoadipic acid pathway that is used for the synthesis of this precursor of penicillin. The lys7 gene, encoding saccharopine reductase in P. chrysogenum, was target inactivated by the double-recombination method. Analysis of a disrupted strain (named P. chrysogenum SR1−) showed the presence of a mutant lys7 gene lacking about 1,000
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45

Froetschel, M. A., W. J. Croom, W. M. Hagler, R. A. Argenzio, J. A. Liacos, and H. P. Broquist. "Effects of Slaframine on Ruminant Digestive Function: Liquid Turnover Rate and Fermentation Patterns in Sheep and Cattle." Journal of Animal Science 64, no. 4 (1987): 1241–48. http://dx.doi.org/10.2527/jas1987.6441241x.

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46

Sibi, Mukund P., and James W. Christensen. "Enantiospecific Synthesis of (−)-Slaframine and Related Hydroxylated Indolizidines. Utilization of a Nucleophilic Alaninol Synthon Derived from Serine1." Journal of Organic Chemistry 64, no. 17 (1999): 6434–42. http://dx.doi.org/10.1021/jo9908546.

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47

TAKAHATA, H., Y. BANBA, and T. MOMOSE. "ChemInform Abstract: Asymmetric Synthesis of 1-Hydroxyindolizidines, Biosynthetic Precursors to the Toxic Indolizidine Alkaloids Slaframine and Swainsonine." ChemInform 22, no. 12 (2010): no. http://dx.doi.org/10.1002/chin.199112329.

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48

Froetschel, M. A., H. E. Amos, J. J. Evans, W. J. Croom, and W. M. Hagler. "Effects of a Salivary Stimulant, Slaframine, on Ruminal Fermentation, Bacterial Protein Synthesis and Digestion in Frequently Fed Steers." Journal of Animal Science 67, no. 3 (1989): 827. http://dx.doi.org/10.2527/jas1989.673827x.

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49

Sibi, Mukund P., and James W. Christensen. "ChemInform Abstract: Enantiospecific Synthesis of (-)-Slaframine and Related Hydroxylated Indolizidines. Utilization of a Nucleophilic Alaninol Synthon Derived from Serine." ChemInform 31, no. 1 (2010): no. http://dx.doi.org/10.1002/chin.200001229.

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50

Gaskins, H. R., W. J. Croom, J. E. van Eys, W. L. Johnson, and W. M. Hagler. "Effects of protein supplementation and parasympathetic stimulation with slaframine on utilization of low quality roughage fed to goats and sheep." Small Ruminant Research 3, no. 6 (1990): 561–73. http://dx.doi.org/10.1016/0921-4488(90)90051-7.

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