Academic literature on the topic 'SLM 280 HL'
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Journal articles on the topic "SLM 280 HL"
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Buican, George Răzvan, Gheorghe Oancea, Camil Lancea, and Mihai Alin Pop. "Some Considerations Regarding Micro Hardness of Parts Manufactured from 316-L Steel Using SLM Technology." Applied Mechanics and Materials 760 (May 2015): 515–20. http://dx.doi.org/10.4028/www.scientific.net/amm.760.515.
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In this paper is investigated the effect of building parts with different layer sizes using an additive manufacturing technique, from the statistical point of view. The paper is focused on the differences that appear at the stainless steel parts when the building layer is increased, this being done on the SLM 250 HL machine. This machine uses a fiber laser to melt fine powder on a layer-by-layer basis to create three-dimensional metallic parts from CAD files. The samples were constructed using two different layer thicknesses and then reprocess so that a micro hardness test could be employed. The micro hardness’s are compared using statistical methods. Overall, the obtained results indicate that the outcome influences the manufacturing strategy that it is chosen.
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Păcurar, Razvan, Ancuţa Păcurar, Nicolae Bâlc, Anna Petrilak, and Ladislav Morovič. "Estimating the Life-Cycle of the Medical Implants Made by SLM Titanium-Alloyed Materials Using the Finite Element Method." Applied Mechanics and Materials 371 (August 2013): 478–82. http://dx.doi.org/10.4028/www.scientific.net/amm.371.478.
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Within this article, there are presented a series of researches that were developed for the first time in Romania, in the field of customized medical implants made by using the Selective Laser Melting (SLM) technology. Finite Element Method (FEM) has been successfully used in order to analyze the fatigue and to determine the durability of a customized medical implant that has been selected for the made analysis. The material characteristics taken into consideration within the Finite Element Analysis (FEA) that has been performed were the ones of two types of dedicated metallic powders which are commercially available (TiAl6Nb7 and TiAl6V4 material) and suitable for the SLM 250 HL equipment from the SLM Solutions GmbH Company from Lubeck, Germany. The Finite Element Analysis made in the case of these two types of SLM titanium alloyed materials, proved that the modified characteristics, such as the yield strength and hardness of the material are significantly influencing the durability of the medical implants made by SLM technology.
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Huang, Hui, Hong Xin, Xinhua Liu, Yajun Xu, Danyi Wen, Yahua Zhang, and Yi Zhun Zhu. "Novel anti-diabetic effect of SCM-198 via inhibiting the hepatic NF-κB pathway in db/db mice." Bioscience Reports 32, no. 2 (November 21, 2011): 185–95. http://dx.doi.org/10.1042/bsr20110017.
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There are reports of early evidence that suggest the involvement of chronic low-grade inflammation in the pathogenesis of Type 2 diabetes. Thus, substances that have effects in reducing inflammation could be potential drugs for Type 2 diabetes. Leonurine (4-guanidino-n-butyl syringate; SCM-198) is an alkaloid in HL (Herba leonuri), which was reported to possess anti-inflammatory properties. We hypothesize that SCM-198 may have beneficial effects on Type 2 diabetes. In the present study, we attempted to test this hypothesis by evaluating the anti-diabetic effect of SCM-198 and the possible underlying mechanisms of its effects in db/db mice. SCM-198 (50, 100 and 200 mg/kg of body weight), pioglitazone (50 mg/kg of body weight, as a positive control) or 1% CMC-Na (sodium carboxymethylcellulose) were administered to the db/db or db/m mice once daily for 3 weeks. After 3 weeks, SCM-198 (200 mg/kg of body weight) treatment significantly reduced the fasting blood glucose level and increased the plasma insulin concentration in the db/db mice, meanwhile it significantly lowered the plasma TAG (triacylglycerol) concentration and increased the HDL (high-density lipoprotein)-cholesterol concentration. Moreover, the dysregulated transcription of the hepatic glucose metabolic enzymes, including GK (glucokinase), G6Pase (glucose-6-phosphatase) and PEPCK (phosphoenolpyruvate carboxykinase), was recovered by an Akt-dependent pathway. The pro-inflammatory mediators {such as TNFα (tumour necrosis factor α), IL (interleukin)-6, IL-1β, degradation of IκB [inhibitor of NF-κB (nuclear factor-κB)] α and thereafter activation of NF-κB} were reversed by SCM-198 treatment in the db/db mice. The present study provides first evidence that SCM-198 exhibits anti-inflammatory activity and has an ameliorating effect on diabetic symptoms via inhibiting of NF-κB/IKK (IκB kinase) pathway. Consequently, we suggest that SCM-198 may be a prospective agent for prevention and/or moderation of the progress of Type 2 diabetes.
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Pothuri, Bhavana, Franco Muggia, Joseph A. Sparano, Stephanie V. Blank, John Patrick Curtin, Ellen Chuang, Dawn L. Hershman, Alice Chen, and Leonard Liebes. "Dose-dependent pharmacokinetic (PK) interaction of pegylated liposomal doxorubicin (PLD) with escalating doses of veliparib in a phase I study." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 2591. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.2591.
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2591 Background: PARP1 inhibition enhances the effects of DNA-damaging agents such as doxorubicin. We sought to investigate PK of PLD in a phase I study of veliparib (ABT-888, V) and PLD in patients (pts) with recurrent ovarian, fallopian tube, and primary peritoneal, and triple negative breast cancers. No prior PK interactions have been described in V clinical trials. Methods: Complete blood samples on day (D) 1 (pre-PLD and 1 hr post PLD), D 8, D 22 on cycle 1 and 2 of treatment in pts receiving PLD 40 mg/m2, day (D) 1 and V D1-14 at varying dose levels of 50,100,150, 200, 300, 350 mg twice daily, were collected in 25 of 31 pts enrolled to a previously reported dose finding phase I study of V and PLD (SGO2012). Plasma PLD levels were measured by HPLC methodology detailed by Gabizon et al Cancer Chemo Pharmacol 2008, 61:695. PK parameter estimates were obtained using non-linear modeling programs available in Winnonlin Ver 5.3. Affect of V dose on PK parameters was estimated with linear regression analysis. Due to a higher degree of GI toxicity with V dosages > 200 mg, we utilized a cut-off of 200 mg for V. PK parameters in the group with dosages greater than or equal to 200 mg (high V, n=18) and those less than 200 mg (low V, n=7) were compared, utilizing an unpaired, 2 sided t-test. Results: PLD clearance (CL) was reduced, half-life (hL) was increased, and AUC/mg was increased with higher dosages of V when compared to historical published data. We noted a positive correlation of the auc/mg dose, p=0.001 and a negative correlation with the CL, p=0.001 and increasing V dose. When analyzed as low and high V groups, the mean ± SEM hL (hrs) was significantly lower in the low V when compared to the high V group, 83.2 ± 11.7 vs 108.6 ± 6.0(p =0.042) , and the mean PLD clearance (ml/h)was greater in the low V versus the high V group 35.9 ± 5.6 vs 14.2 + 1.0, P<.0001. Similarly the AUC/mg dose (mg x h/L) was significantly lower in the low vs high V groups, 35.0 ±5.2 vs 74.9 ± 4.4, P<0.0001. Conclusions: Higher exposure of PLD is noted with V at doses greater than or equal to 200 mg twice daily. An expansion cohort with patients receiving PLD alone in cycle 1, and PLD + V 200 mg twice daily in subsequent cycles, will validate the presence of a PK interaction. Clinical trial information: NCT01145430.
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Wang, Chang, Hai-Jie Hu, Qing-Qing Dong, Rui Huang, Wei Zhao, Ya-Jian Song, Zhong-Yuan Li, Nan Wang, Tong-Cun Zhang, and Xue-Gang Luo. "Enhancing bile tolerance of Lactobacilli is involved in the hypolipidemic effects of liraglutide." Bioscience, Biotechnology, and Biochemistry 85, no. 6 (March 30, 2021): 1395–404. http://dx.doi.org/10.1093/bbb/zbab053.
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ABSTRACT Liraglutide is an analog of human glucagon-like peptide-1 which play essential roles in regulation of glycolipid metabolism. To investigate role of lactic acid bacteria (LAB) in lipid-lowering effect of liraglutide, 40 mice were divided into normal food diet (NFD), high-fat food (HFD), 10.0 mg/kg/d simvastatin-treated HFD (SIM + HFD), 200 and 400 µg/kg/d liraglutide-treated HFD (LL + HFD and HL + HFD) groups for 5 weeks. We found that liraglutide could upregulate cholesterol 7α-hydroxylase (CYP7A1) and LDL-receptor (LDLR), whereas downregulate 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). Besides, liraglutide enhance abundance of lactobacillaceae in gut of hyperlipidemic mice and increase bile tolerance ability of LAB by upregulating bile salt hydrolases, and the lysate of liraglutide-sensitive LAB could also directly downregulate HMGCR, the key enzyme in cholesterol synthesis, and inhibit hepatocyte steatosis. These findings might provide new theoretical guidance for clinical application of liraglutide and research and development of antiobesity, hypolipidemic, and cholesterol-lowering drugs or functional foods.
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Safarmamadov, Safarmamad M., Davron A. Muborakkadamov, and Kimyo S. Mabatkadamova. "COMPLEXATION OF GOLD (III) WITH 1-FURFURYLIDENE AMINO-1,3,4-TRIAZOLE AT 288 – 318 K." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 60, no. 5 (June 23, 2017): 37. http://dx.doi.org/10.6060/tcct.2017605.5439.
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The potentiometric titration method was used to determine the ionization constant of 1-furfurylideneamino-1,3,4-triazole (pKk = 11.83 log.). The dominating region of 1-furfurylideneamino-1,3,4-triazoles (FF) was identified in a wide pH range. It was shown that 1-furfurylideneamino-1,3,4-triazole ion (HL+) predominates in the pH range up to 0.5-2.0. At pH of 5.0 to 10.5, the neutral molecule (L) predominates, and at pH>13.0 1-furfurylideneamino-1,3,4-triazolate ion (L-) predominates in a solution. To determine the number of a particles formed during the interaction of Au (III) with FF from the potentiometric titration data the dependence of ΔE on -lg [FF] was used for 1-furfurylideneamino-1,3,4-triazole gold (III) complexes at 288-318 K. The slope of the curves of the ΔE-lg [FF] with the excess of 1-furfurylideneamino-1,3,4-triazole at temperatures of 288, 298 and 308 K is 0.059, 0.060 and 0.061 V/mol/l-1, which corresponds to the sequential addition of three molecules of 1-furfurylideneamino-1,3,4-triazole to gold (III). At the temperature of 318 K it is not possible to find the slope angle corresponding to the tris complex due to a quick change in the potential with an excess of FF in a solution. General stability constants of 1-furfuryldenoamino-1,3,4-triazole complexes of Au (III) according to potentiometric titration data was determined by the Friedman method and non-linear least squares method. It was shown that as the temperature increases, the general stability constants of gold (III) complexes are reduced. It was shown that the introduction of substituents into the 1,2,4-triazole molecule affects both the number of particles formed in a solution and the stability of the complexes. Thus, in the system Au (III) -1,2,4-triazole-H2O at 298 K four complex particles are formed, and in the Au (III) system, 1-furfurylideneamino-1,3,4-triazole-H2O only three are formed. The general stability constants of 1,2,4-triazole complexes equal to lgβ1 = 6.56, lgβ2 = 11.13, lgβ3 = 14.94 and lg4 = 18.78 log units, and for 1-furfurylideneamino-1,3,4-triazole complexes Igβ1 = 5.92, lgβ2 = 10.14, lgβ3 = 13.80 log units. The thermodynamic functions of complexe formation were calculated by the temperature coefficient method. It was shown that all complex particles are enthalpy-stabilized. The greatest increase in the exothermicity of the reactions is observed when a complex of three organic-ligand molecules is formed. The value of ΔS at all steps of complexation is negative, which is most likely due to the decrease in the number of particles in a system under study. The spontaneous reaction of complexation is determined by the enthalpy factorFor citation:Safarmamadov S.M., Muborakkadamov D.A., Mabatkadamova K.S. Complexation of gold (III) with 1-furfurylidene amino-1,3,4-triazole at 288 – 318 K. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 5. P. 37-43.
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Zou, Min, Zhiqiang Zhong, and Chunju Wen. "Characterization and anti-acute myeloid leukemia and anti-acute T cell leukemia properties of zinc nanoparticles synthesized by a green approach for bioremediation applications." Archives of Medical Science, August 2, 2021. http://dx.doi.org/10.5114/aoms/140295.
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IntroductionEvery year, many people die due to cancer in all of the world. So, the preparation and formulation of new chemotherapeutic supplements and drugs with remarkable effects to treat cancer are the priority of both developing and developed countries. In this study, zinc nanoparticles were synthesized in an aqueous medium using Fumaria officinalis leaf as stabilizing and reducing agents.Material and methodsThe green synthesized ZnNPs@ Fumaria officinalis were characterized using different techniques including UV-visible and FT-IR spectroscopy, X‐ray diffraction (XRD), scanning electron microscopy (SEM), and Energy Dispersive X-ray Spectrometry (EDS). The anticancer activity of ZnNPs@ Fumaria officinalis was evaluated against acute myeloid leukemia and acute T cell leukemia.ResultsAccording to the XRD analysis, 20.44 nm was measured for the crystal size of the nanoparticles. SEM images showed a uniform spherical morphology with an average size of 27.96 nm for ZnNPs@ Fumaria officinalis. In the cellular and molecular part of the recent study, the treated cells with ZnNPs@Fumaria officinalis were assessed by MTT assay for 48h about the cytotoxicity and anti-human acute leukemia properties on normal (HUVEC), acute myeloid leukemia (32D-FLT3-ITD and Human HL-60/vcr), and acute T cell leukemia (Jurkat, Clone E6-1 and J.RT3-T3.5) cell lines. The IC50 of ZnNPs@Fumaria officinalis were 227, 200, 250, and 336 µg/mL against 32D-FLT3-ITD, Human HL-60/vcr, Jurkat, Clone E6-1, and J.RT3-T3.5 cell lines, respectively.ConclusionsThe viability of malignant leukemia cell line reduced dose-dependently in the presence of ZnNPs@Fumaria officinalis. It appears that the anti-human acute leukemia effect of ZnNPs@Fumaria officinalis is due to their antioxidant effects.
Dissertations / Theses on the topic "SLM 280 HL"
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Skalický, Petr. "Zpracování vysokopevnostní hliníkové slitiny EN AW 7075 technologií SLM." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2017. http://www.nusl.cz/ntk/nusl-318662.
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This diploma thesis deals with processing of high strength aluminum alloy EN AW 7075 by Selective Laser Melting and verify the influence of process parameters on relative density and mechanical properties. The theoretical part contains an introduction to additive manufacturing of aluminum alloys, the influence of process parameters and description of processes occuring during SLM production. Based on the theoretical part were prepared experiments and method of evaluation. Samples were produced by melting metallurgical powder using ytterbium laser with a maximum output power of 400 W. This diploma thesis also describes the formation and growth of cracks inside the material, which so far in the literature for alloy EN AW 7075 were not described. As the result, the process parameters dependence on the relative density and an overview of this aluminum alloy processing by SLM technology is determined.
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Kočica, Martin. "Zpracování slitin mědi pomocí technologie selective laser melting." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2016. http://www.nusl.cz/ntk/nusl-241911.
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This diploma thesis deals with finding copper alloy suitable for processing SLM technology and determining the process parameters leading to a relative density close to the full material. The theoretical part provides an insight into additive technology and the processing of new alloys in SLM. Work also contains a search report of processed copper alloys used in SLM. Based on the theoretical part were designed test samples and method of evaluation. Samples were produced by melting metallurgical powder using ytterbium laser with an output power 400 W. The testing is divided into three stages; Determination of the parameters of the SLM process, Debug strategies for larger parts, Geometric precision and mechanical testing. Based on the results was determined dependence of relative density on the input parameters. For the best parameters were determined geometric precision correction and mechanical properties.
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Dokoupil, Filip. "Zpracování slitiny 2618 pomocí technologie selective laser melting." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2015. http://www.nusl.cz/ntk/nusl-231934.
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This diploma thesis deals with finding and verification of appropriate technological parameters of SLM technology for the processing of aluminum alloy 2618. In the theoretical part, an introduction to additive manufacturing of aluminum alloys and general description of processes occurring during SLM production is given. Based on general knowledge were designed different types of testing samples produced by sintering the metallurgical powder using 400 W ytterbium fiber laser, which so far in the literature for aluminum alloy 2618 were not described. As the result, the technological parameters dependence on relative density and the detailed overview of the 2618 alloy processing by SLM technology is determined.
Conference papers on the topic "SLM 280 HL"
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Ho, Jin Yao, Kin Keong Wong, Kai Choong Leong, and Chun Yang. "Enhanced Nucleate Pool Boiling From Microstructured Surfaces Fabricated by Selective Laser Melting." In ASME 2016 5th International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/mnhmt2016-6616.
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Selective laser melting (SLM) is a promising manufacturing method which enables the production of complex structured components from base metal powders. With the development of SLM, the possibility of fabricating functional heat transfer devices such as heat pipes and heat sinks using this technique has also gained significant interest in the recent years. In this paper, the possibilities of producing microstructured surfaces using SLM to promote nucleate pool boiling heat transfer were explored. The SLM facility (SLM 250 HL by SLM Solutions GmbH) at the Future of Manufacturing Laboratory 1 of Singapore Centre for 3D Printing (SC3DP) in Nanyang Technological University (NTU), Singapore was employed for the fabrication of the surfaces. The machine is comprised of a Gaussian distributed Yb:YAG laser with maximum power of 400 W and laser beam spot size of 80 μm which melts and fuses the AlSi10Mg base powder of distribution size 20 μm to 63 μm layer-by-layer to develop three-dimensional structures. In total, four 1 cm × 1 cm microstructured surfaces were produced; namely micro-cavity surface, micro-fin surface, micro-sized rectangular channel (MRC) surface and micro-sized square channel (MSC) surface. Saturated pool boiling experiments were conducted on these surfaces in a water-cooled thermosyphon with FC-72 as the coolant fluid under atmospheric condition. In comparison with a plain surface, the MRC and MSC surfaces exhibited marginal improvements in the average heat transfer coefficient whilst more significant enhancements of up to 51.2% were demonstrated with the micro-cavity and micro-fin surfaces. At low heat fluxes (< 7 W/cm2), minimal differences in heat transfer performances between the microstructured surfaces and plain surface were observed. For increased heat fluxes, incremental enhancements in the heat transfer coefficients were observed for the micro-cavity and micro-fin surfaces as compared to the plain surface. The highest enhancement in the heat transfer coefficient over the plain surface was determined to be 63.5% for the micro-fin surface at the heat flux of 17.9 W/cm2 and it was also observed that the heat transfer coefficient of micro-fin surface is consistently higher that of other microstructured surfaces for the range of heat fluxes tested. In addition, higher critical heat fluxes were also achieved with all microstructured surfaces as compared to the plain surface with the highest CHF of 46.2 W/cm2 for the micro-fin and MRC surface. Visual observations suggest that the enhancement in heat transfer from the microstructured surfaces is likely to be due to the increased bubble nucleation sites created from the extended surfaces and the artificial cavities. In summary, these results indicate the promising use of SLM to produce surface features that will enhance pool boiling heat transfer.