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Cohat, Hervé. "Le SLO (Scanning Laser Ophthalmoscope) : principes d'utilisation et applications." Montpellier 1, 1993. http://www.theses.fr/1993MON11167.
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McCormick, Neil Howie. "Bayesian methods for automatic segmentation and classification of SLO and SONAR data." Thesis, Heriot-Watt University, 2001. http://hdl.handle.net/10399/452.
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TERZIC, ZORAN. "Les applications du slo dans les dmla : l'exploration de l'acuite visuelle centrale." Université Louis Pasteur (Strasbourg) (1971-2008), 1993. http://www.theses.fr/1993STR1M074.
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Flatt, Taylor. "CrowdCloud: Combining Crowdsourcing with Cloud Computing for SLO Driven Big Data Analysis." OpenSIUC, 2017. https://opensiuc.lib.siu.edu/theses/2234.
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The evolution of structured data from simple rows and columns on a spreadsheet to more complex unstructured data such as tweets, videos, voice, and others, has resulted in a need for more adaptive analytical platforms. It is estimated that upwards of 80% of data on the Internet today is unstructured. There is a drastic need for crowdsourcing platforms to perform better in the wake of the tsunami of data. We investigated the employment of a monitoring service which would allow the system take corrective action in the event the results were trending in away from meeting the accuracy, budget, and time SLOs. Initial implementation and system validation has shown that taking corrective action generally leads to a better success rate of reaching the SLOs. Having a system which can dynamically adjust internal parameters in order to perform better can lead to more harmonious interactions between humans and machine algorithms and lead to more efficient use of resources.
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Steimer, Tanja [Verfasser], and Ralf S. [Akademischer Betreuer] Müller. "Symmetrische Lupoide Onychomadesis (SLO) beim Bearded Collie / Tanja Steimer ; Betreuer: Ralf S. Müller." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1192215435/34.
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Silva, Inês Maria Tavares de Almeida e. "The role of SLO in aGVHD: alterando o paradigma de allo-activação das células T." Doctoral thesis, Universidade de Aveiro, 2010. http://hdl.handle.net/10773/3319.
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Doutoramento em Ciências da Saúde<br>A indução da doença do transplante contra o hospedeiro (GVHD) depende da activação das células dadoras T pelas células do hospedeiro que apresentamantigenio (APCs). A teoria prevalecente descreve que estas interacções ocorrem nos órgãos linfáticos secundários (SLO), tais como os nóduloslinfáticos (LN), as placas de Peyer’s (PP) e o baço (SP). Esta hipótese foi testada usando ratinhos homozigóticos aly/aly (alinfoplasia) que não têm LN nem PP, usando como controlo os ratinhos heterozigóticos (aly/+) da mesma ninhada. Os dois grupos foram irradiados com dose letal após a remoção do baço aos ratinhos aly/aly (LN/PP/SP-/-), enquanto nos ratinhos aly/+ o baço foi deslocado e recolocado. Ambos receberam transplante de medula óssea (BMT) de ratinhos dadores singénicos (aly/aly, H-2b) ou de ratinhos alogénicos, com diferente complexo principal de histocompatibilidade (MHC) (BALB/c, H-2dou B10.BR, H-2k). A severidade de GVHD foi medida pela sobrevivência,e pelo sistema de pontuação, bem estabelecido, quer de doença clínica quer de doença dos órgãos alvo. Surpreendentemente, todos os ratinhos LN/PP/SP-/-sobreviveram, desenvolvendo GVHD clinicamente significativo, comparável,em severidade, com o observado nos ratinhos LN/PP/SP+/+. Além disso, asanálises histopatológicas demonstraram que os ratinhos LN/PP/SP-/-receptores de BMTdesenvolveram significativamente mais GVHD no fígado,no intestino, e na pele quando comparados com os animais singénicos decontrolo. Os ratinhos LN/PP/SP-/-desenvolveram também GVHD hepático mais severo quando comparados com os ratinhos de controlo LN/PP/SP+/+. Diferenças semelhantes foram ainda observadas, logo ao 7º dia, para o GVHDhepático entre os grupos alogénicos. Para identificar quais os órgãos extra-linfáticos do receptor que poderão servir como sítios iniciais de exposição a antigenios alogénicos, na ausência de SLO, foi examinada a expansão das células T (CD3+), a sua activação (CD69+), e a sua proliferação (CFSE) na medula óssea, 3 dias depois do BMT. Em cada caso, os ratinhos LN/PP/SP-/-transplantados com medula de dadores alogénicos apresentaram númerosabsolutos significativamente maiores quer de células, quer de divisõescelulares, se comparados com os LN/PP/SP+/+. Para garantir que as diferenças experimentais observadas nos animais aly/aly, no sistema díspar do MHC, não são apenas um fenómeno dependente da estirpe de ratinho, foramtransplantados ratinhos sem baço FucT dko (LN/PP/SP-/-), previamente tratados com o anticorpo monoclonal (mAb) anti-MadCAM-1. Após o BMT estes ratinhos apresentaram elevada pontuação clínica de GVHD, mostrando que os SLO não são necessários para a indução de GVHD. Em estudos de transplante-versus-leucemia usando hospedeiros homozigóticos (LN/PP/SP-/-) estes ratinhos morreram devido a expansão tumoral e não devido a GVHD.Estudos in vitro mostraram que a capacidade das APCs, quer das célulasdendríticas (DCs) esplénicas, quer das DCs derivadas da medula óssea, dosratinhos aly/aly e aly/+ eramcomparável. Colectivamente, estes resultados são consistentes com a noção de que os SLO não são necessários para a activação alogénica das celulas T, sugerindo que a medula óssea pode ser umlocal alternativo, embora menos eficiente, para o reconhecimento alogénico deantígenos e consequente activação das células dadoras T. Estas observações desafiam o paradigma de que os tecidos linfáticos secundários sãonecessários para a indução de GVHD.<br>The induction of graft-versus-host disease (GVHD) fundamentally depends upon the activation of donor T cells by host antigen presenting cells (APCs).The prevailing view is that these critical interactions occur in secondarylymphoid organs (SLO), such as lymph nodes (LN), Peyer’s patches (PP) and spleen (SP). This hypothesis was tested by using homozygous aly/aly(alymphoplasia) mice that are deficient in all LN and PP, while heterozygousaly/+ littermates served as controls. Lethally irradiated, splenectomized, aly/aly(LN/PP/SP-/-) mice andsham splenectomized aly/+ (LN/PP/SP+/+) mice received bone marrow transplant (BMT) either from syngeneic (aly/aly, H-2b) or allogeneic, major histocompatibility complex (MHC) disparate donors (BALB/c,H-2d or B10.BR, H-2k). The severity of GVHD was assessed by survival and the well-established scoring systems of both clinical and target organ disease.Surprisingly, all LN/PP/SP-/-mice survived and they developed significant clinical GVHD comparable in severity to LN/PP/SP+/+ mice. Moreover,histopathologic analysis demonstrated that LN/PP/SP-/- BMT recipients developed significantly greater liver, intestinal tract and skin GVHD comparedto syngeneic animals. These mice also developed more severe hepatic GVHDcompared to allogeneic littermate controls. Similar differences in liver GVHDwere also seen between allogeneic groups as early as day 7. To ascertain whatextra-lymphoid host tissues might serve as initial sites for allo-antigen exposure in the absence of SLO, it was examined donor T cell expansion (CD3+), activation (CD69+) and proliferation (CFSE) in bone marrow 3 days after BMT.In each case, it was found that LN/PP/SP-/- allo-BMT recipients had significantly higher absolute cell numbers as well as cell divisions compared toallogeneic, LN/PP/SP+/+ littermate controls. To ensure that experimental differences seen with aly/alyanimals in the MHC disparate system did not solely represent a strain-dependent phenomenon, we used the monoclonal antibody (mAb) anti-MadCAM-1 pretreated FucT dko splenectomizedmice (LN/PP/SP-/-recipients) as recipients. These mice showed elevated clinicalGVHD scores following BMT, providing evidence that SLO are not required for the induction of GVHD. In graft-versus-leukemia (GVL) studies using homozygous (LN/PP/SP-/-) as recipients, these mice died from tumor expansion and not from GVHD. In vitro studies demonstrated that the allo-stimulatory capacity of APCs, including both splenic and BM-derived dentritic cells (DCs), from aly/aly and aly/+ were comparable. Collectively, these data are consistent with the notion that SLO are not required for allogeneic T cellactivation and suggest that the bone marrow may represent an alternative,albeit less efficient site for allo-antigen recognition and donor T cell activation. These observations challengethe paradigm that secondary lymphoid tissues are required for GVHD induction.
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Mazinani, Babac [Verfasser], and O. Sebastian [Akademischer Betreuer] Wolf. "Normalwerterhebung bei der multifokalen Elektroretinographie bei Monitor- und SLO-Stimulation / Babac Arisa Ebrahim Mazinani ; Betreuer: O. Sebastian Wolf." Aachen : Universitätsbibliothek der RWTH Aachen, 2003. http://nbn-resolving.de/urn:nbn:de:hbz:82-opus-6432.
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Mazinani, Babac Arisa Ebrahim [Verfasser], and O. Sebastian [Akademischer Betreuer] Wolf. "Normalwerterhebung bei der multifokalen Elektroretinographie bei Monitor- und SLO-Stimulation / Babac Arisa Ebrahim Mazinani ; Betreuer: O. Sebastian Wolf." Aachen : Universitätsbibliothek der RWTH Aachen, 2003. http://d-nb.info/1127531573/34.
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Owen, Kennedy. "On the Impact of Android API Evolution on Education Materials." DigitalCommons@CalPoly, 2017. https://digitalcommons.calpoly.edu/theses/1766.
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The recent growing popularity of mobile devices has led to the establishment of several popular mobile platforms such as the Android operating system. To foster growth in this evolving market, Application Programming Interfaces (APIs) were created to enable developers to create mobile device applications that utilize mobile device features and functionality for personal or widespread commercial use. However, as a result of excessive device and API evolution, mobile development faces increasingly complex issues, including an alarmingly rapid decay of development resources.
This thesis conducts a case study around one such resource: a series of Android app development lab exercises used in an Android app development course taught at California Polytechnic State University, San Luis Obispo. First, these labs and their respective written guides were modernized and fitted for backwards-compatibility to better reflect newer Android devices and development tools at the time. The updated labs were subsequently used in the next course offering, with student lab feedback recorded for evaluation. Several years later, the apps from these new labs were further tested for abnormal behavior on a variety of Android devices. Results from analyzing all feedback and observations show that despite all measures taken to future-proof these labs, Android device and API evolution continues to vastly outpace third-party Android resources without frequent modernization and upgrades.
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Gruchy, Nicolas. "Implication de la voie de signalisation Sonic Hedgehog (Shh) dans 2 syndromes : la trisomie 18 et le syndrome de Smith-Lemli-Opitz (SLO)." Caen, 2014. http://www.theses.fr/2014CAEN3001.
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La trisomie 18 (T18) et le syndrome de Smith-Lemli-Opitz (SLO) sont 2 syndromes polymalformatifs pour lesquels un déficit en cholestérol est observé. En prénatal, ils s’associent à un taux effondré d’œstriol non conjugué maternel (uE3), marqueur du dépistage de la trisomie 21, reflétant le taux de cholestérol fœtal. L’ajout de cholestérol à Sonic Hedgehog (Shh) lui assure une activité maximale. Certaines malformations surviennent dans des tissus où Shh joue un rôle primordial. L’objectif de cette étude rétrospective portant sur des cas de T18 et de SLO fœtaux était de déterminer si le déficit en cholestérol était à l’origine de l’altération de la voie Shh et de malformations. Le nombre de celles-ci a été corrélé au taux d’uE3 maternel. Nous avons dosé le cholestérol dans le milieu de culture d’amniocytes de T18, SLO et de témoins par LC/MSMS, puis testé l’expression de gènes de la voie Shh par RT-PCR quantitative : les facteurs GLI, et des gènes cibles de Shh : BMP2, BMP4, TGFβ1, COL1A1 et COL1A2. L’expression protéique de Shh, BMP2 et COL1 a été testée. Enfin, l’expression de ces gènes a été évaluée dans des amniocytes témoins traités par inhibiteur de synthèse du cholestérol. L’activité de liaison des GLI a été étudiée par gel retard. On observe une corrélation inverse entre la sévérité phénotypique et le taux d’uE3 dans le SLO et la T18. Le taux de cholestérol dosé dans le milieu de culture d’amniocytes est corrélé au taux d’uE3 et significativement plus bas en cas de T18 et de SLO. On rapporte une diminution d’expression des gènes testés et une différence d’activité de liaison des GLI en cas de T18. Cette perturbation n’est pas significative dans les amniocytes traités<br>Trisomy 18 (T18) and Smith Lemli Opitz (SLO) syndrome are two polymalformative conditions in which cholesterol defect was noticed. Prenatally, they are associated with a decreased maternal unconjugated estriol (uE3) level, one of the second trimester maternal serum screening test that reflects fetal cholesterol level. Addition of cholesterol allows Shh protein maturation. Many malformations in these 2 syndromes occur in Shh dependent tissus. We thus sought to assess whether cholesterol defect could affect Shh pathway and explain malformations. We selected trisomy 18 and SLO cases in which maternal uE3 level was decreased and reported fetal malformations. We correlated the number of malformations with maternal uE3 level. We carried out cholesterol dosage in culture medium of trisomy 18, SLO and control amniocytes through LC/MSMS. We then analyzed Shh pathway in testing gene expression of several Shh components : GLI transcription factors, and Shh targets : BMP2, BMP4, TGFβ1, COL1A1 and COL1A2. Protein expression of Shh, BMP2 and COL1 was tested. Gene expression was also tested in control amniocytes treated with an anti-cholesterol. Finally, GLI binding activity was tested using gel retardation assay. We observed an inverse correlation between phenotypic severity and maternal uE3 level in SLO and trisomy 18. Cholesterol level in culture medium of amniocytes is correlated with maternal uE3 level and significantly lower in T18 and SLO amniocytes. There is an alteration in Shh pathway as expression of several genes is decreased in T18 and SLO amniocytes. We also observed a different GLI binding activity in T18 amniocytes. This alteration is not significant in treated amniocytes
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Toscano, Daniela Araújo. "Análise da reprodutibilidade da espessura da camada de fibras nervosas da retina utilizando-se o Spectralis SLO OCT e sua concordância com Stratus OCT." reponame:Repositório Institucional da UnB, 2012. http://repositorio.unb.br/handle/10482/10834.
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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, Programa de Pós-Graduação em Ciências Médicas, 2012.<br>Submitted by Jaqueline Ferreira de Souza (jaquefs.braz@gmail.com) on 2012-06-27T13:19:21Z
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2012_DanielaAraujoToscano.pdf: 1639141 bytes, checksum: 9269a3edec99fb2ad296cfabf7f193e7 (MD5)<br>Este estudo teve por objetivo analisar a reprodutibilidade do SD SLO OCT Spectralis e comparar os dados deste OCT com outro já bastante difundido no mercado, como o TDOCT Stratus. Esse estudo foi dividido em duas partes: na primeira delas foram estudados 151 olhos de 79 pacientes sem glaucoma (grupo 1) e 72 pacientes com glaucoma (grupo 2). Para a segunda parte, foram incluídos 110 olhos, sendo 60 sem glaucoma e 50 com glaucoma. Foram realizados em todos os olhos e em apenas uma visita, três B-scans circulares centrados no disco óptico utilizando-se o Spectralis, e na segunda fase, também o Stratus. A média da idade foi de 58 ±11 e 68±10 anos, para o grupo 1 e 2, respectivamente. O ICC, COV e TRV para a média de espessura da camada de fibras nervosas da retina (CFNR) foram respectivamente: 0,94, 2,56% e 4,85m para o grupo 1, e 0,93, 4,65% e 6,61m para o grupo 2. As medidas de espessuras da CFNR foram semelhantes comparando-se os dois aparelhos, com exceção do quadrante superior no grupo 1, e do temporal, no grupo 2 (p<0,0001). Analisando o gráfico de Bland-Altman, foi observado um boa concordância entre as medidas de espessura da CFNR entre o Spectralis e o Stratus. Concluiu-se que o Spectralis apresentou uma excelente reprodutibilidade da espessura da CFNR. Além disso, não houve diferença estatisticamente significante entre as espessuras aferidas com o Spectralis versus o Stratus, exceto no quadrante superior para pacientes sem glaucoma e quadrante temporal para pacientes com glaucoma. Houve uma excelente concordância entre os dois OCTs. _________________________________________________________________________________ ABSTRACT<br>The goal of the present study was to analyze the reproducibility of SD SLO OCT Spectralis and compare this data with other OCT used worldwide, as TDOCT Stratus. This study was divided in two parts: in the first part a total of 151 eyes of 79 patients without glaucoma (group 1) and 72 glaucomatous patients (group 2) were analyzed. For the second part, 110 eyes, 60 without glaucoma and 50 with glaucoma were enrolled. All patients’ eyes were scanned using the Spectralis and in the second part of the study, also the Stratus. Three consecutive circular B-scan centered at the optic disc were performed in one visit. The average age was 58±11 and 68±10 years old for the group 1 and 2, respectively. The ICC, COV and TRV for the mean RNFL thickness were respectively: 0.94, 2.56% and 4.85m for the group 1, and 0.93, 4.65% and 6.61m for the group 2. Only in the superior quadrant for the group 1 and temporal for the group 2, the RNFL thickness difference was statistically significant (p0.0001). Analyzing the Bland-Altman concordance graphs it was observed excellent concordance between the RNFL thickness measured by Spectralis and Stratus. The Spectralis showed excellent reproducibility with regard to RNFL thickness measurements. In addition, there were no statistically significant differences between RNFL measurements by Spectralis and Stratus, except for superior quadrant in the patients without glaucoma and temporal quadrants in glaucomatous patients. In conclusion, there was an excellent concordance between the two OCTs.
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Kolf-Clauw, Martine. "Toxicite sur le developpement des inhibiteurs de la delta-7 sterol reductase chez le rat : modele d'etude pour le syndrome congenital humain : slo/rsh." Paris 7, 1997. http://www.theses.fr/1997PA077238.
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Le syndrome polymalformatif humain smith-lemli-opitz (slo/rsh), autosomal recessif, peut comprendre plusieurs anomalies de developpement, de gravite variable : dysmorphie faciale, microcephalie, retard psychomoteur et staturoponderal, anomalies des organes genitaux, des extremites, diverses anomalies viscerales. Ce syndrome a ete recemment associe a un deficit de l'activite de la 3-hydroxysteroide-7-reductase expliquant hypocholesterolemie et accumulation de 7-dehydrocholesterol (7-dhc) chez les patients. Afin de reproduire les anomalies biochimiques du syndrome slo, des rattes gestantes ont recu une dose unique d'ay9944, inhibant la 7-dhc reductase. L'evolution des sterols au cours de la gestation a ete suivie parallelement par colorimetrie et par cg-sm. La technique colorimetrique sous-estime l'hypocholesterolemie, car elle a mesure 70% du 7-dhc dans un essai de supplementation. Nos resultats en gc-sm ont montre l'interet de ce modele animal ; apres administration le 4eme jour de gestation, 77% des foetus ont presente une agenesie hypophysaire a j21. L'induction d'holoprosencephalies de diverses gravites avec une autre molecule, le bm15766, a permis de demontrer que la teratogenese est due a l'inhibition enzymatique. Les anomalies cranio-faciales ont ete precisees, cette etude a confirme que l'agenesie hypophysaire isolee est la forme mineure de l'holoprosencephalie. Les domaines d'expression des genes otx1, otx2, emx2, pax6 ont ete analyses par hybridation in situ sur coupes seriees, avec reconstructions tridimensionnelles. Sur des embryons de 23 somites, des anomalies morphologiques du prosencephale ont ete observees, associees a des lacunes d'expression des genes otx1 et otx2, surtout en partie dorsale et laterale du prosencephale. L'anomalie la plus frappante a ete l'absence du signal otx2 ventralement au niveau de l'infundibulum, et sa deletion rostrale, associee a une absence de tissu. Nos resultats sont compatibles avec l'hypothese d'une perte de fonction de shh, suggeree dans le slo.
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Hansi, Elina. "En relation utan kontakt : En fallstudie av gruvdriften i Kallak med fokus på Beowulf Minings förhållningssätt till samernas traditionella marker." Thesis, Stockholms universitet, Statsvetenskapliga institutionen, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-143833.
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I Sverige bedrivs idag den största mineralutvinningen på samernas traditionella marker. Samerna har inte några lagligt bindande rättigheter till dessa marker, vilket skapat en politisk konflikt mellan ursprungsbefolkningen och de kommersiella gruvbolagen. Med utgångpunkt i det politiska läget och med särskilt fokus på den planerade gruvan i Kallak syftar denna studie till att studera det kommersiella bolaget Beowulf Minings förhållningssätt till samerna och resursutvinningen på deras marker. Med hjälp av teorierna Carrolls moralpyramid och Social License to Operate (SLO) samt metoden argumentationsanalys vill studien granska hur bolaget legitimerar gruvdriften på samernas marker samt se hur bolaget förhåller sig till samerna och deras sociala tillåtelse. Genom analys av bolagets externa rapportering fann studien att Beowulf Mining främst legitimerar gruvdriften genom att argumentera för de positiva fördelar som gruvdriften kan få för Jokkmokk och dess lokalbefolkning. Studien fann även att bolaget använder sig av det rättsliga ramverket som en särskild legitimering för deras aktiviteter samt att bolaget ger uttryck för att ha ett lokalt stöd från en del av Jokkmokks befolkning. Vidare påvisade analysen att bolaget inte haft någon utförlig relation till samerna och inga muntliga dialoger genomförts. Detta, tillsammans med att samerna sällan omnämns i dokumenten, leder till slutsatsen att gruvbolaget inte kan påvisa några meningsfulla försök till att få samernas tillåtelse av den planerade gruvdriften samt att en bestående relation inte existerar i nuläget mellan de två parterna.
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Fournstedt, Daniel. "Jämförelse mellan Scheimpflug imaging och anterior segment OCT i mätning av Corneal tjocklek." Thesis, Linnéuniversitetet, Institutionen för medicin och optometri (MEO), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-44694.
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Purpose: The purpose of this study was to compare corneal thickness measured both centrally and midperipherally, between two instruments using different measuring principles. The study also looked at correlation between corneal thickness and intraocular pressure (IOP). Methods: Central and midperipheral corneal thickness was measured on the right eyes of 31 subjects with two different instruments. Instruments were Scheimpflug-camera from Bon Sirius and an AS/OCT from Optos. Measurements were taken on central cornea (CCT) and midperipheral (nasal (NCT), temporal (TCT), superior (SCT) and inferior (ICT)) at a distance of 1.75 mm from the apex. Mean age of the subjects was 23.6 ± 4.5 years. (19-44 years). A CT-80A non-contact tonometer (NonCT) from Topcon was used to measure the intraocular pressure (IOP). Results: A mean-value for central corneal thickness was calculated to 542.4 µm and 540.4 µm for Bon Sirius and AS/OCT repectively. Remaining measured points had mean-values for corneal thickness of, NCT: 577.7 µm & 558.5 µm. TCT: 555.0 µm & 545.2 µm. SCT: 585.7 µm & 554.5 µm. ICT: 563.0 µm & 548.9 µm, respectively. Mean-difference for CCT was 2.4 µm and it showed a significant difference between the two instruments with a p-value of 0.007. Remaining measured points all showed a significant difference of p<0.05. NCT: 19.2 µm. TCT: 9.8 µm. SCT: 31 µm. ICT: 14 µm. A correlation between IOP and CCT measured in both Sirius and AS/OCT was positive with r = 0.7 and p<0.05. Conclusion: The results showed that Sirius gives higher values for corneal thickness then ASOCT in all five measurement points. The results show that these instruments can be used interchangeably when measuring central corneal thickness. However, caution should be used when measuring midperipheral corneal thickness as the there is a significant differences between these two instruments.
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Alqadah, Amel. "Molecular mechanisms of olfactory neuron diversification in C. elegans." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1455208834.
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Lachheb, Sahran. "Etude des canaux potassiques de la membrane basolatérale du néphron distal de souris." Paris 6, 2007. http://www.theses.fr/2007PA066232.
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Des canaux K+ basolatéraux du néphron distal de souris ont été identifiés. Un canal de 140 pS dans la TAL, activé par le Na+ et le Cl- intracellulaires, est de la famille des canaux KNa des cellules excitables et encodés par le gène Slo2. 2. Ce canal permettrait le recyclage basolatéral du K+ entré par la Na+-K+ ATPase en réponse à un flux entrant apical de NaCl dans la TAL. Un canal de 40 pS dans le CCD, à rectification entrante et inhibé par la spermine, est insensible à l’ATP intracellulaire, mais modulé par le pH intracellulaire (pKa = 7. 3). Ces données et celles de PCR en temps réel et d’immunohistochimie, indiquent la présence d’un canal Kir4. 1/Kir5. 1. Lors d’un régime appauvri en Na+, l’activité du canal est augmentée, indiquant son importance dans l’augmentation du recyclage de basolatéral de K+ liée à la stimulation de l’influx apical de Na+ et de la Na+-K+ ATPase dans ces conditions. Le canal Kir4. 1/Kir5. 1 serait le canal K+ basolatéral majoritaire le long du néphron distal<br>We studied basolateral K+ channels of mouse distal nephron, where they maintain cell membrane potential and take part to renal ions absorption. We used patch-clamp, immunohistochemistry and real-time PCR to study the properties of a 140 pS K+ channel in the thick ascending limb of Henle’s loop (TAL) cells, and of a 40 pS K+ channel in cortical collecting duct (CCD) principal cells, and identify their molecular nature. In TAL, the 140 pS K+ channel was ATP- and pH independent, but was strikingly activated by intracellular sodium and chloride concentrations. It therefore closely resembles Na-dependent K+ channels of excitable tissues, encoded by the Slo2. 2 gene. As Slo2. 2 mRNA is present in TAL cells and in no other nephron segment, we concluded that the basolateral membrane of mouse TAL cells is endowed with a Slo2. 2 type, Na+- and Cl--activated K+ channel which may link basolateral K+ recycling and Na+-K+ ATPase activity to apical entry of NaCl. In CCD, the 40 pS K+ channel displayed a Mg2+-dependent rectification, and a concentration- and voltage-dependent inhibition by spermin. Its activity is ATP-independent but is modulated by intracellular pH (pKa = 7. 3). This, together with real-time PCR and immunohistochemistry data, correlate well with a heterotetrameric Kir4. 1 / Kir5. 1 channel. A low-Na+ diet significantly increased channel activity, indicating that it may increase the basolateral recycling of K+ during increased of apical Na+ entry and basolateral Na+-K+ ATPase activity in theses conditions. As Kir4. 1 / Kir5. 1 channel is present in all along the distal nephron, it may appear as a major component of basolateral potassium conductance
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Wrighton, David Charles. "Pharmacology & regulation of Slo2 and Slo3 potassium channels." Thesis, University of Leeds, 2011. http://etheses.whiterose.ac.uk/2025/.
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Large-conductance-Ca2+-activated potassium Slo1 channels are well characterised members of the Slo channel family. The other members, Slo3 and Slo2.χ, are less characterised and their physiological roles are elusive. Little is known of the pH-sensitive Slo3 channel, aside from a role regulating Ca2+ influx through CatSper channels during capacitation in spermatozoa. This thesis aims to investigate mSlo3 pharmacology and determine if mSlo3- EST’s encode novel isoforms. Na+-activated Slo2.χ channels (Slo2.1/Slo2.2) are thought to mediate adaptation of neuronal action potential firing rate and slow after hyperpolarisations following repetitive firing. We aim to characterise hSlo2.2a currents and their bithionol sensitivity, an activator of a rat isoform. Mutation of the conserved phenylalanine in the S6-domain (mSlo3-F304/hSlo1-F380) to tyrosine has similar effects on Slo channels, namely a negative shift in the voltagedependence of activation and an increase in membrane conductance. mSlo3 pharmacology matches the IKSper profile and suggests roles for mSlo3 as a pharmacological target in infertility treatment. This work identified a novel splice-variant of mSlo3; CV562866 lacks transmembrane domains and is more widely expressed than mSlo3. CV562866 protein is expressed in vivo, and contains the nominal RCK2 domain. CV562866 affects functional expression of mSlo3 and mSlo1 channels in Xenopus oocytes, decreasing and increasing expression respectively. This study examined the hSlo2.2a channel characteristics, which unlike the previously reported rSlo2.2a channel, mediates a non-rectifying K+ current. Bithionol activates hSlo2.2a channels with an EC50 of 1.29±0.12μM and activation was Na+ co-operative. We found a candidate bithionol binding site in the C-terminal domain near the “Cl- bowl”. Due to toxicity of hSlo2.1 expression; determination of the bithionol selectivity of Slo2.χ channels was unattainable. In vivo, Slo2.χ channels act as a background K+ conductance, activated by a variety of conditions, stabilising the resting membrane potential of the cell. This study suggests Slo2.χ are viable pharmacological targets for treatment of inflammatory pain.
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Běťák, Ondřej. "Multimodální registrace retinálních snímků z fundus kamery a OCT." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2012. http://www.nusl.cz/ntk/nusl-219716.
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V první části se práce se zabývá rešerší metod a principů potřebných při registraci obrazu. Dále pak popisuje zobrazovací systémy očního pozadí jako jsou OCT, fundus kamera a SLO. Druhá část práce je zaměřena na praktickou realizaci programů pro registraci snímků z OCT, SLO a fundus kamery v programovém prostředí Matlab.
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Andr, Ondřej. "Srovnání on-page SEO faktorů pro mobilní web." Master's thesis, Vysoká škola ekonomická v Praze, 2015. http://www.nusl.cz/ntk/nusl-204028.
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The thesis deals with a topic of SEO onpage signals, which are important for search engines because of sorting pages in a search engine result page. It focuses on importance of these signals for mobile SERP. Main goals of this study are to describe current recommendations for SEO on-page factors for mobile web and experimentally test real importance of these signals. Based on the results I composed an optimal set of factors with the most benefit for SEO. Theoretical part of the study summarizes basic facts about mobile searching, describes specific mobile users behaviour and describes current recommendations for mobile web onpage optimizing from Google and Seznam.cz. In practical part there is a comparative study of chosen on-page signals. For its needs I had to create few one page static websites. Each one has been optimized for on factor. All websites focused on the same very specific topic to ensure the same initial conditions. By keywords rank tracking in a SERP I was able to determine which signal is more important than others for search engines. The study results contribute to actual evaluation of each on-page signals importance for mobile website. The study could be beneficial for smaller companys websites, which need to get more visible on the net. They are able to optimize their costs by choosing the right set of on-page factors.
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West, Connor M. "Continuum Modeling of the Densification of W-Ni-Fe during Selective Laser Sintering." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1577.
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The purpose of this thesis is to effectively model the time history of the temperature distribution during the selective laser sintering process and use this information to investigate the resulting relative density. The temperature is a critical parameter of the process because it directly effects the overall quality of the part. First, an efficient, affordable, and reliable simulation was developed within the finite element software, Abaqus. Next, the results from the simulations were compared to the experimental results performed by Wang et al. (2016). The FEA model consisted of a 3 layer simulation. Multiple simulations at various laser recipes were conducted using W-Ni-Fe as the powder material. The P/v (laser power/scanning speed) was plotted against the resulting total time above the melting temperature for various simulation. It was concluded that a linear relationship exists between the P/v parameters used in the laser recipe and the resulting time above the melting temperature. The average R2 values for the W-Ni-Fe simulations for layer 1, 2, 3 were 0.962, 0.950, and 0.939, respectively. Additionally, the experimental results from the Wang et al. (2016) study confirmed that a linear relationship is present. Thus, it can be concluded that the P/v parameters used within the laser recipe has a direct relation to the resulting relative density of the SLS part.
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Lukić, Slobodan. "Bogutovo Selo : selo koje o(p)staje : monografija." Bijeljina Srpsko Kulturno i Prosvjetno Društvo Prosvjeta, 2004. http://bvbr.bib-bvb.de:8991/F?func=service&docl̲ibrary=BVB01&docn̲umber=016778118&linen̲umber=0001&funcc̲ode=DBR̲ECORDS&servicet̲ype=MEDIA.
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Harper, J. M. "Smooth SLE." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603730.
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The search for the scaling limits of two-dimensional critical systems has been a very active area of research in Statistical Physics. Recently, a new technique for the analysis of these scaling limits was developed after the introduction of a process known as the Stochastic Loewner Evolution (SLE) by Oded Schramm. This process is a stochastic version of the Loewner chain from classical complex analysis, in which the driving function of the chain is taken to be a Brownian motion. The behaviour of SLE has been widely studied and has enabled the rigorous identification of the scaling limits of several discrete critical systems including critical site percolation on the triangular lattice. Many other systems are also conjectured to converge to some SLE-related process. The study of the behaviour of SLE has also lead to the exact calculation of many quantities relating to the asymptotic behaviour of these discrete models. In this study, we review the theory of classical Loewner chains before introducing a process that can be viewed as a smooth analogue of a Loewner chain. We study the properties of this process and show that it possesses a greater degree of regularity than a classical Loewner chain; in particular, we show that the planar domains associated with the smooth chain have smooth boundaries. We then study these smooth chains in the stochastic setting of Schramm, calling the resulting process a smooth SLE. One main difference between SLE and smooth SLE is that SLE possesses a certain scale-invariance, whereas smooth SLE processes do not. This scale-invariance is often crucial to the proofs of the behaviour of SLE and therefore any proof of corresponding behaviour for the smooth case must use other methods. The extra regularity of the smooth chain implies that some of the behavioural exhibited by an SLE process is not seen for a smooth chain. However, the main behavioural phase change, seen for SLE when the variance parameter of the driving Brownian motion is changed, is also seen in the smooth case. Finally, we examine issues relating to the approximation of smooth Loewner chains and also the convergence of these smooth chains to their classical counterparts.
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Pink, Glen Alan. "Slot Filling." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17055.
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Slot filling (SF) is the task of automatically extracting facts about particular entities from unstructured text, and populating a knowledge base (KB) with these facts. These structured KBs enable applications such as structured web queries and question answering. SF is typically framed as a query-oriented setting of the related task of relation extraction. Throughout this thesis, we reflect on how SF is a task with many distinct problems. We demonstrate that recall is a major limiter on SF system performance. We contribute an analysis of typical SF recall loss, and find a substantial amount of loss occurs early in the SF pipeline. We confirm that accurate NER and coreference resolution are required for high-recall SF. We measure upper bounds using a naïve graph-based semi-supervised bootstrapping technique, and find that only 39% of results are reachable using a typical feature space. We expect that this graph-based technique will be directly useful for extraction, and this leads us to frame SF as a label propagation task. We focus on a detailed graph representation of the task which reflects the behaviour and assumptions we want to model based on our analysis, including modifying the label propagation process to model multiple types of label interaction. Analysing the graph, we find that a large number of errors occur in very close proximity to training data, and identify that this is of major concern for propagation. While there are some conflicts caused by a lack of sufficient disambiguating context—we explore adding additional contextual features to address this—many of these conflicts are caused by subtle annotation problems. We find that lack of a standard for how explicit expressions of relations must be in text makes consistent annotation difficult. Using a strict definition of explicitness results in 20% of correct annotations being removed from a standard dataset. We contribute several annotation-driven analyses of this problem, exploring the definition of slots and the effect of the lack of a concrete definition of explicitness: annotation schema do not detail how explicit expressions of relations need to be, and there is large scope for disagreement between annotators. Additionally, applications may require relatively strict or relaxed evidence for extractions, but this is not considered in annotation tasks. We demonstrate that annotators frequently disagree on instances, dependent on differences in annotator world knowledge and thresholds on making probabilistic inference. SF is fundamental to enabling many knowledge-based applications, and this work motivates modelling and evaluating SF to better target these tasks.
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Collier, Samantha Noelle. "Silo tree." Thesis, University of Iowa, 2015. https://ir.uiowa.edu/etd/1573.
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Ingemarsson, Cristoffer, and John Bovellán. "SILO 72 : Ombyggnad av Lantmännens silo i Östra Hamnen, Västerås." Thesis, Mälardalens högskola, Akademin för hållbar samhälls- och teknikutveckling, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-13966.
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This project includes a small study of Västerås city's housing needs, and a proposal on theuse of the property 1:207, Lantmännens silo in the Eastern Harbour, Västerås.The project intends to produce a basic study of the useful systems for this rebuilding projectwith regards to sustainable development and energy saving light buildings.The end result, which consists of a detailed visualization of the proposal, intends to becomean iconic natural focus for the Eastern port of Västerås and an example of the use andadaptation of existing structures.The property must also link the eastern parts of Västerås with the center through anextension of Mälarleden.The work has been performed through literature studies, site visits, contacts with the City ofVästerås and by calculations.The proposal consists of architectural proposals drawings and visualizations.Furthermore, a suggestion is given of how the property can be used and fitted into theoverall plan for urban density development currently underway in the city of Västerås.Computer programs used have been Microsoft Office Excel, AutoCAD and ArchiCAD.
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Pine, Shannon Robert. "Manufacturing structurally integrated three dimensional phased array antennas." Thesis, Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-04062006-115019/.
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Thesis (M. S.)--Mechanical Engineering, Georgia Institute of Technology, 2006.<br>Dr. Jonathan Colton, Committee Chair ; Dr. John Muzzy, Committee Member ; Dr. Daniel Baldwin, Committee Member ; Dr. John Schultz, Committee Member.
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Gopinath, Varun. "Industrial Silo Optimization." Thesis, Linköpings universitet, Maskinkonstruktion, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-67645.
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This thesis aims to build a working design-analyze-optimize methodology for Alstom Power Sweden AB at Växjö, Sweden. In order to be profitable in today’s competitive industrial product market, it is necessary to engineer optimized products fast. This involves CAD design and FEA analysis to work within an optimization routine in a seamless fashion which will result in a more profitable product. This approach can be understood as a model-based design, where the 3D CAD data is central to the product life cycle. The present approach provides many benefits to a company because of the use of a central database ensure access to the latest release of the 3D model. This allows for a streamlined design to fabrication life cycle with inputs from all departments of a product based company. Alstom is looking into automating some of their design process so as to achieve efficiency within their design department. This report is the result of a study where an industrial silo is taken as an example. A design loop involving CAD design and FE analysis is built to work with an optimization routine to minimize the mass and also ensure structural stiffness and stability. Most engineers work with a lot of constraints with regard to material stock size and other design codes (e.g. Euro Codes). In this report an efficient way to design an industrial product in a 3D CAD (CATIA) program so as to stay within these constrains and still obtain credible computation results within an optimization loop will be discussed.
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Veikutis, Donatas. "SEO taikymo analizė." Bachelor's thesis, Lithuanian Academic Libraries Network (LABT), 2012. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120702_123614-02385.
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Visuomenė, internetas ir jame esanti informacija dabar turi vieną didžiausių įtakų mūsų asmeniniame gyvenime. Be interneto daugelis dabar, net nebeįsivaizduotų savo kasdienybės, nes jis mums ir padeda atlikti daugelį darbų. Tačiau vis augant duomenų kiekiams internete, informacijos paieška tampa vienu svarbiausių internete naudojamų funkcijų.Paieškos sistemos – tai sistemos, ieškančios dokumentų žiniatinklyje, naujienų grupių archyvuose, FTP saugyklose, kuriuos rado paieškos serveris ir įtraukė į savo duomenų bazes. Ieškant informacijos, vartotojai naudojasi šiomis sistemomis, todėl internetinių svetainių kūrėjai yra suinteresuoti, kad jų internetiniai puslapiai būti kuo dažniau randami paieškos sistemų. Todėl besiplečiant paieškos sistemoms išsiplėtojo SEO (Search Engine Optimization, lietuviškai „Optimizavimas paieškos sistemoms“).<br>Expansion of the Internet and the information contained therein formed such an organization which aims to help the internet users to quickly and efficiently find what he needs. One of them is the Google search engine. It is one of the largest search engine companies in the world. In this paper we will analyse the Google search engine, and its proposed content optimization methods, which it claims to helps achieve better search results positions. The paper will discuss techniques such as HTML meta tags, content headers, site maps, robots.txt file, canonical and Paging functions. These methods will be compared with each other, and we will decide which method is most useful for site optimization.
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Koutný, Jiří. "Data driven SEO." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-150119.
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The Search Engine Optimization (SEO) industry has recently undergone major changes. Many new analytics tools have been put on the market enabling marketing consultants to be finally able to measure and evaluate the results of their work in SEO effectively. The theoretical part of this diploma thesis therefore aims to describe and compare selected SEO tools including practical examples of their use. The paper is focused on backlink databases (MajesticSEO, SEOmoz OpenSiteExplorer and Ahrefs) and keyword suggestion tools from Google (AdWords), Seznam (Sklik), Wordtracker and SEMRush. The final chapter provides an overview of search engine positions tracking tools and techniques. The practical part describes the method of selection, preparation and processing of data obtained from tools mentioned above. The data are used to compute correlation analysis of Seznam.cz search engine results in relation with the best known SEO factors. The results of the analysis will help marketing consultants to clarify which factors are the most important to focus on to obtain more traffic from search engines.
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Theodossopoulos, Konstantinos. "Rectilinear slot model of an inclined slot radiator in rectangular waveguide." Thesis, Heriot-Watt University, 2000. http://hdl.handle.net/10399/577.
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Klus, Jakub. "Nová koncepce údržby a provozu výrobních technologií." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-449712.
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This diploma thesis deals with a new concept of maintenance and operation of production technologies, where spare parts are manufactured using rapid prototyping methods. The options are compared with currently used methods. Furthermore, methodological recommendations are written on how to proceed with the application. The aim of the work is to evaluate the concept and confirm the theoretical assumptions on a case study.
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Doležal, Petr. "Analýza WWW stránek na základě klíčových slov." Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-165111.
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This thesis is about keyword research for optimization of web pages. The thesis is mainly focused on on-page factors which are connected with keywords and key phrases. The goal of the thesis is design of methodics for keyword research and its evaluation on the basis of practical usage. The design of methodics is based on theoretical and practical knowledge and experience and it is the main contribution of the thesis. Usage of the keyword research is very wide, it forms the basis of creation of a web and content of the web. Everybody should learn the methodics, who wants to promote his web in competitive area, who wants to get to know his customers better and to generate higher profit, because the methodics is beneficial for all these and other reasons. The first part is theoretical basis. It shows the position of keyword research in SEO and in web mining. Further the important terms connected with keywords are defined. Keyword properties and methods to gaining keywords for website optimization are described either. Further various targets and metrics for measuring these targets are introduced. Next the most important tools for keyword research and characteristics of the two most used search engines for the Czech Republic (Google and Seznam) are described. The second part includes the design of the methodics for keyword research which consists of data collection, website optimization and monitoring of changes. Individual processes of methodis are described in practical experiments for particular web pages. The effectiveness of the methodics is evaluated at the end.
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Leuchten, N., B. Milke, B. Winkler-Rohlfing, et al. "Early symptoms of systemic lupus erythematosus (SLE) recalled by 339 SLE patients." Sage, 2018. https://tud.qucosa.de/id/qucosa%3A35523.
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Objective: The European League Against Rheumatism and the American College of Rheumatology jointly embarked on a new classification criteria for systemic lupus erythematosus (SLE) project. Its first phase involved generation of a broad set of items potentially useful for classification of SLE. This study was undertaken to add the patient perspective to an expert Delphi approach and an early patient cohort study. Methods: A national cross-sectional study was conducted. A self-report questionnaire was published in the ‘‘Schmetterling’’ (Butterfly), the quarterly journal of the German SLE patient association. Individuals with SLE were asked to anonymously complete the questionnaire, which asked for demographic details, organ manifestations, autoantibodies and symptoms.
Results: A total of 339 completed questionnaires out of 2498 were returned, a response rate of 13.6%; 83.2% reported they were ANA positive and 81.7% reported joint, 66.1% skin and 33.0% renal involvement. For the time before and in the first year after their SLE diagnosis, the majority reported fatigue (89.4%), joint pain (86.7%), photosensitivity (79.4%) and myalgia (76.1%). Of interest, more than half of the patients reported fever as an early symptom (53.7%).
Conclusion: For a Caucasian European SLE patient population, the overall characteristics suggest meaningful representation. While many symptoms were reported as expected, the high percentage of patients reporting fever and the significant number of patients with unexpected gastrointestinal complaints are of particular interest. These data add to the information on early SLE symptoms informing the development process of new SLE classification criteria.
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JUNIOR, OSWALDO BAPTISTA HORACIO E. SILVA. "CAVITY-BACKED SLOT ANTENNAS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2004. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=6003@1.
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MARINHA DO BRASIL<br>Os sistemas que operam em banda larga necessitam de
radiadores que atendam eletricamente a banda de freqüência
utilizada. As antenas com características de independência
da freqüência, em particular as antenas espirais, têm
encontrando cada vez mais utilização nesses sistemas, seja
em aplicações comercias ou militares. Esta dissertação tem
por objetivo a análise de desempenho de antenas espirais do
tipo fenda em cavidades, pela aplicação do método dos
momentos. Serão consideradas cavidades com a face oposta à
antena constituída por um condutor perfeito ou acoplada a
uma estrutura de microondas com matriz de espalhamento
conhecida. Essa estrutura de microondas, poderá simular,
por exemplo, uma ou mais camadas de material absorvente.Um
modelo numérico foi desenvolvido, e a partir dele foi
elaborado um programa de computador, para determinar as
características de radiação de antenas espirais em
cavidade. São apresentados e comparados os resultados
obtidos para três configurações de antenas espirais de
Arquimedes do tipo fenda: sem cavidade, com cavidade
condutora e com um material absorvente colocado sobre a
face da cavidade oposta a abertura da antena.<br>Broad band systems need radiators to operate over the
entire frequency band. Frequency independent antennas, in
particular spiral antennas, are finding increasing
application in such systems, for commercial or military
purposes. This dissertation has for objective the analysis
of performance of cavity-backed slot spiral antenna, by
applying the moment method . For this study it will be
taken into account cavities with the face opposing to the
antenna consisting of a perfect conductor or connected to a
structure of microwaves with known scattering matrix. This
microwave structure will be able to simulate, for example,
one or more layers of absorbing material. A numerical model
was developed, and based on it, it was elaborated a
computer program to determine the radiation characteristics
of cavity-backed spiral antennas. The results surveyed for
three configurations of slot Archimedean spiral antenna are
presented and compared: without cavity, with conducting
cavity, and with an absorbing material placed on the cavity
opposite to the antenna.
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Guerra, Sandra. "Gene polymorphisms in SLE." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/gene-polymorphisms-in-sle(96ff1bac-bcca-40f1-bfd7-24bc87dc7a25).html.
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Systemic lupus erythematosus (SLE) is an autoimmune disease, with a strong genetic component. It is characterised by hyperactive T and B cells, chronic inflammation and the production of antinuclear autoantibodies. SLE affects mostly women of child baring age, with a 9:1 ratio, women to men and has been reported to be more prevalent in people of non-European ancestry. In the era of genome-wide association studies (GWAS), elucidating the genetic factors present in SLE has been very successful, with over 28 confirmed disease susceptibility loci mapped and a number of candidate genes identified. During this thesis I fine mapped IL18 as it had previously been reported to be associated with SLE, SNP rs360719. After fine mapping and subphenotype analysis in UK and African American cohorts, I was unable to replicate the published association. Although genetic data did not confirm IL18 to be associated with SLE, I demonstrated increased IL-18 serum levels in SLE renal patients compared to SLE patients. I further analysed IL10, another previously associated SLE candidate loci in our current SLE GWAS cohort (4000 cases and 9000 controls) of European ancestry. I again was unable to replicate the previous association, however using other SLE GWAS data showed SNP rs3024505 to be associated in Northern European samples. Further analysing our SLE GWAS, I located IKZF3 as a candidate loci. I identified an associated block of 56 SNPS and located the association to a single SNP rs2941509, p=1.46xlQ-8. Furthermore, I demonstrated an allelic imbalance in this SNP, with the protective G allele being expressed 1.5 times greater than the risk A allele, in controls. These data here demonstrated in this thesis indicates the importance of fine mapping candidate loci and verification of previously associated loci. This thesis contributes to the current knowledge of SLE by demonstrating discrepancies in published association data and showing the importance of larger studies.
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Han, Yong. "Some problems about SLE." Thesis, Orléans, 2017. http://www.theses.fr/2017ORLE2007/document.
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Cette thèse se concentre sur trois sujets liés aux SLE(k) processus. La première partie concerne le processus dipolar SLE(k) et la mesure de restriction conforme à la bande ; La deuxième partie porte sur la propriété de connectivité de la mesure de la boucle brownienne ; Et la troisième partie porte sur le spectre des moyens intégrés généralisés du processus entier intérieur des processus Loewner piloté par un processus Lévy<br>This thesis focuses on three topics related to the SLE(k) processes. The first part is about the dipolar SLE(k)process and the conformal restriction measure on the strip ; the second part is about the connectivity propertyof the Brownian loop measure ; and the third part is about the generalized integral means spectrum of the innerwhole plane Loewner processes driven by a Lévy process
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Štefl, Jan. "SEO - optimalizace pro vyhledávače." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2008. http://www.nusl.cz/ntk/nusl-235984.
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Visiblity of page assume that is situated at top positions in search engines results for particular keywords. Search engine optimization is collection of rules, that should pass every page. In this thesis is described all essences of this technique, including methodology, that helps create optimized pages.
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Špaček, Petr. "Nástroj pro SEO analýzu." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2011. http://www.nusl.cz/ntk/nusl-237037.
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The thesis deals with SEO problems (Search Engine Optimization). The part of the thesis is creation of tool which analyzes web pages in multilanguage versions and results provides with appropriate educational effect for user. According the analyzing that can be also used in the regular interval it's possible to show optimization history. The tool uses Microsoft technologies, especially ASP.NET, SQL Server 2008 or Microsoft Server 2008 and is developed by Visual Studio 2010.
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Komárek, Miroslav. "SEO optimalizace webových stránek." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-15618.
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The goal of this thesis is to analyze methods and techniques applying to Search Engine Optimization (SEO). The thesis combines theoretical knowledge extracted from scientific sources and from author's experiences. Search Engine Optimization methods are divided into two major chapters according to sphere of their activity. On Page Factors -- factors occuring on web pages and Off Page Factors -- factors affecting web pages but occuring out of web pages. There is a case study at the end of this thesis. Acquired knowledge are used there. The case study is based on real-world project and includes detailed results and economical indicators.
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Diblík, Jan. "SEO optimalizace webových stránek." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-76673.
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The topic of this thesis is search engine optimization (SEO). This term covers many activities, procedures and techniques. When using SEO you can improve your position in a search engine and narrow it to so called key words. The first part of the theoretical part acquaints readers with the basic facts, statistics and defines the basic terminology. The main objective of the second part is concentrated on the main elements which affect the successes of optimalization. The practical part is dealing with analysis of the optimalized e-shop including its competitors. The changes and recommendations of improvement and development of the e-shop were suggested on the basis of the analysis, the theoretical acquirements and the experience of the author. These changes are gradually implemented in the following part of the thesis. The impact on the attendance and placement in the search engines is reviewed after the realization of the suggested above.
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Engelbrecht, Sarah. "Design of meso-scale cellular structure for rapid manufacturing." Thesis, Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/33876.
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Customized cellular material is a relatively new area made possible by advancements in rapid manufacturing technologies. Rapid manufacturing is ideal for the production of customized cellular structure, especially on the meso scale, due to the size and complexity of the design. The means to produce this type of structure now exist, but the processes to design the structure are not well developed. The manual design of customized cellular material is not realistic due to the large number of features. Currently there are few tools available that aid in the design of this type of material. In this thesis, an automated tool to design customized cellular structure is presented.
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Latef, Ahmed. "Caractérisation de catalyseurs Mo/SiO et Pt-Mo/SiO par R.P.E et S.P.X." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37607053n.
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Alfaya, Antonio Alberto da Silva. "Preparação, caracterização e propriedades dos fosfatos de oxidos mistos SiO²/TiO² e SiO²/ZrO²." [s.n.], 2000. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249677.
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Orientador: Yoshitaka Gushikem<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-07-25T20:03:57Z (GMT). No. of bitstreams: 1
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Wagle, Shyam Sharan <1982>. "SLA Violation Detection Model and SLA Assured Service Brokering (SLaB) in Multi-Cloud Architecture." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amsdottorato.unibo.it/7791/1/WAGLE_ShyamSharan_tesi.pdf.
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Cloud brokering facilitates CSUs to find cloud services according to their requirements. In the current practice, CSUs or Cloud Service Brokers (CSBs) select cloud services according to SLA committed by CSPs in their website. In our observation, it is found that most of the CSPs do not fulfill the service commitment mentioned in the SLA agreement. Verified cloud service performances against their SLA commitment of CSPs provide an additional trust on CSBs to recommend services to the CSUs. In this thesis work, we propose a SLA assured service-brokering framework, which considers both committed and delivered SLA by CSPs in cloud service recommendation to the users.
For the evaluation of the performance of CSPs, two evaluation techniques: Heat Map and IFL are proposed, which include both directly measurable and non-measurable parameters in the performance evaluation CSPs. These two techniques are implemented using real data measured from CSPs. The result shows that Heat Map technique is more transparent and consistent in CSP performance evaluation than IFL technique. In this work, regulatory compliance of the CSPs is also analyzed and visualized in performance heat map table to provide legal status of CSPs. Moreover, missing points in their terms of service and SLA document are analyzed and recommended to add in the contract document. In the revised European GPDR, DPIA is going to be mandatory for all organizations/tools. The decision recommendation tool developed using above mentioned evaluation techniques may cause potential harm to individuals in assessing data from multiple CSPs. So, DPIA is carried out to assess the potential harm/risks to individuals due to our tool and necessary precaution to be taken in the tool to minimize possible data privacy risks. It also analyzes the service pattern and future performance behavior of CSPs to help CSUs in decision making to select appropriate CSP.
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Skala, Jakub. "Modelování podnikových procesů." Master's thesis, Vysoká škola ekonomická v Praze, 2008. http://www.nusl.cz/ntk/nusl-12361.
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The diploma thesis deals with the theme of Modeling business processes with orientation to the metric process interface. The aim of the thesis is to design the architecture of metric, which enabled to construct type metrics of the process interface. Firstly, the reader is informed about the basic terms related to process modeling, process management and connection of strategy with metrics. The next part describes the architecture of metrics created, which is oriented to supporting the process management of the organization. The set of type metrics was chosen with consideration to the possibility of their placement on process interface. The set created in this manner should help to connect strategy with processes when implementing into organization. The last part of the thesis describes the practical application of knowledge obtained in the PARMA project. This project deals with the proposal and implementation of the process management into the Bureau of the Municipality of Prague 10. The thesis deals with two processes and the conclusions obtained in the theoretic part of the thesis are applied herein.
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Jandl, Štěpán. "Online marketing internetových stránek Golfprint.eu." Master's thesis, Vysoká škola ekonomická v Praze, 2012. http://www.nusl.cz/ntk/nusl-199047.
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The Master's thesis "Online marketing of website Golfprint.eu" deals with various aspects of website pages Golfprint.eu. The main objective of Master's thesis is based on the analyzes and studies to assess the specific Internet project, examine the strategy and formulate concrete proposals and recommendations with a view to the next time period. In addition to the broadly defined area of internet marketing and learn about the standard tools and factors that ensure an adequate commercial success. At the same detail to present selected web project and specify its main aims and objectives in the marketplace.
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Pererva, Volodymyr S. Plivačuk Kateryna V. "Selo Buky : minule, sučasne, majbutnje /." Bila Cerkva : Pšonkivs·kyj, 2008. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=016788165&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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Svartsjaern, Mikael. "Footwall stability in SLC mining." Doctoral thesis, Luleå tekniska universitet, Geoteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-65420.
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This thesis is based on a case study of the Kiirunavaara sublevel cave (SLC) mine. It focuses on footwall stability and damage development in the mining infrastructure on mine scale. Damage to the infrastructure is mappable for the full height of the footwall by access through decommissioned infrastructure associated with earlier mining stages. Damages range from pure structurally controlled failures (wedge failures) in the upper part of the footwall to fracture growth through intact rock combined with micro‑seismic emissions at the active mining depth. The thesis addresses four distinct research questions; (i) What are the predominant failure mechanisms for the Kiirunavaara footwall? (ii) What is the role of confinement on the damage development in the footwall? (iii) How does the SLC relate to the footwall damage development? (iv) How can infrastructure damage associated to the future mining be estimated using currently available data? Two sets of calibrated numerical models were used to study the damage evolution processes using damage mapping data as the main calibration parameter. Validation of the models was achieved by correlation of model output to micro-seismic locations. The modelling and damage mapping results were used as the basis for the development of a simple prognosis tool for estimating the ultimate extent of infrastructure damage associated to the mining advance for future mining steps. A literature review on slope failure modes, large scale failures in cave mining and failure tracking using micro-seismic locations is included to provide background and definitions. The literature describes principal failure modes as well as mechanism combinations such as structurally controlled failures initiated by deep seated rock mass failures or relaxation. Cases are presented where previously stable structures become destabilised by cave advance and examples where micro‑seismic recordings were used to track deformations and the initiation and growth of newly formed fractures. The Kiirunavaara SLC mine is presented in detail as the main case study of the work. The mine has been in operation since the early 20th century with a transition to underground operation over 50 years ago. The extent of the orebody is 4 km in length with an average width of 80-90 m, the termination at depth has yet to be determined. The ore has an average dip of 60˚ east and a dip-along-strike to the north. Both the footwall and hangingwall rock masses are considered hard and competent with UCS values for the footwall ranging from ca. 130 MPa to extreme cases of 600 MPa. The ore is mined in production blocks about 400 m wide (along strike), Mining of the northernmost blocks, situated in the Lake ore, did not start as open pit operations but has been accessed from the underground via SLC only. The instabilities in the footwall has been addressed by several research studies in the past, with the predominant failure mechanisms in different studies being suggested as large scale tensile failure, complex wedge failure, or rotational shear failure, i.e., some type of principal slope failure. In this work, conceptual numerical models in UDEC were calibrated to fit underground damage mapping data by tracking numerical shear strain concentrations. The conceptual models suggested rock mass damage without the indications of development of large scale slope failure mechanisms such as shear bands. Mine scale PFC models were calibrated with respect to the rock mass strength parameters derived by the conceptual UDEC models and used to study rock mass fracturing in the absence of large scale failure. It is shown that damage to the rock mass occurs mainly close to the active mining in a seismically active zone. This is suggested to weaken and soften the rock mass to allow the development of infrastructure damage in this volume to occur as the rock mass relaxes when entering the stress shadow of the SLC as mining progresses. The damage to the rock mass at the production depth is argued, based on seismic records and a parametric study in UDEC, to constitute of large quantities of local shear failures coalescing to appear as a large scale step-path or rotational shear failure in mapping records. The extent of the associated infrastructure damage is predicated to be limited by the extent of the damaged rock mass zone. A simple bi-linear equation is suggested using ore-width and mining depth as input to estimate the ultimate extent of the damaged zone for each mining stage and thus the limit of later infrastructure damage development. The thesis is concluded with recommendations for future work and potential for continued research.<br>Denna avhandling baseras på en fallstudie av skivrasgruvan Kiirunavaara. Fokus ligger på liggväggstabilitet och skadeutveckling på gruvans infrastruktur i gruvskala. Infrastrukturskador kan karteras längs med hela liggväggens höjd där tillgång till bergmassan ges via urdrifttagna ortar och ramper drivna i samband med tidigare brytningssteg. Dokumenterade skador varierar med djupet – från strukturstyrda brott i den övre delen av liggväggen till ny sprickbildning genom intakt berg kombinerat med mikro-seismik vid nuvarande brytningsdjup. Fyra distinkta forskningsfrågor avhandlas; (i) Vilka är de dominerande brottsmekanismerna i Kiirunavaaras liggvägg? (ii) Vilken roll spelar inspänning för brottsutvecklingen i liggväggen? (iii) På vilket sätt relateras skivrasbrytningen till brottsutvecklingen? (iv) Hur kan skador på gruvans infrastruktur kopplat till framtida brytningssteg uppskattas med data tillgängliga idag? Två omgångar med kalibrerade numeriska modeller togs fram för att studera skadeutvecklingen i liggväggen med skadekarteringsdata som primär kalibreringsparameter. Validering av modellerna uppnåddes genom att studera samstämmigheten mellan modellresultaten och lokaliseringen av mikro-seismiska händelser. Modellresultaten och skadekarteringsdatabasen användes som grund för att utveckla ett enkelt prognosverktyg för att uppskatta den slutgiltiga utbredningen av infrastrukturskador direkt associerade med gruvbrytningen för framtida brytningssteg. En litteraturstudie av släntbrott, storkskaliga brott i samband med rasbrytning samt brottsövervakning med mikro-seismik är inkluderad som bakgrund och för att definiera terminologier som används genom avhandlingen. Literaturstudien beskriver principiella brottsmekanismer samt kombinationer av mekanismer såsom strukturstyrda brott pådrivna av djupt belägna bergmassebrott eller minskad inspänning. Fallstudier presenteras där tidigare stabila strukturer destabiliseras av rasbrytningens framskridande och exempel där mikro-seismikdata använts för att följa deformationer samt initiering och tillväxt av nya sprickor i intakt berg och bergmassa. Kiirunavaaragruvan presenteras i detalj som den huvudsakliga fallstudien för arbetet. Gruvan har varit aktiv sedan tidigt 1900-tal med övergång till underjordsbrytning för över 50 år sedan. Malmkroppens utbredning är 4 km längs strykningen med en genomsnittlig vidd av 80-90 m, och malmkroppens fortsättning mot djupet är öppen. Malmen har en genomsnittlig stupning av 60 grader öst med en fältstupning mot norr. Bergmassan i både liggvägg och hängvägg anses vara hård och kompetent med UCS värden för liggväggen mellan ca. 130 MPa till extrema fall av 600 MPa. Malmen bryts i produktionsblock med ca 400 m bredd (längs malmens strykning). Brytning av de nordligaste blocken, belägna i Sjömalmen, har inte skett i dagbrott utan har utförts enbart via skivrasbrytning. Instabiliteten i liggväggen har avhandlats i ett flertal tidigare studier. De dominerande brottsmekanismerna har föreslagits i tidigare arbeten som storskaligt dragbrott, komplext kilbrott eller cirkulärt skjuvbrott d.v.s. någon typ av principiellt släntbrott. I arbetet för denna avhandling kalibrerades konceptuella numeriska modeller i UDEC mot skadekarteringsdata från liggvägens underjord, med avseende på koncentrationer av skjuvtöjningar. De konceptuella modellerna visade på bergmasseskador utan indikationer på storskaligt släntbrott, exempelvis koncentrationer av numeriska skjuvband. PFC-modeller i gruvskala kalibrerades gentemot bergmasseparametrarna från de konceptuella studierna i UDEC för att direkt studera upprickningen av bergmassan i frånvaro av storskaliga brottsindikationer. Modellerna visade på att skador i bergmassan främst uppkommer nära brytningsområdet i en seismiskt aktiv zon. Detta föreslås försvaga och mjukgöra bergmassan vilket i sin tur leder till utveklingen av infrastrukturskador i den skadade volymen när berget avlastas då området hamnar i spänningsskugga från skivraset. Ovanstående studier visar att skadorna som uppkommer i bergmassan, baserat på de konceptuella UDEC-modellerna och mikro-seismiska data, består av ett stort antal lokala skjuvbrott vilka samverkar till att framstå som ett storskaligt trappstegsbrott eller cirkulärt skjuvbrott i skadekarteringsdatat. Utbredningen av de relaterade infrastrukturskadorna förutspås begränsas av utbredningen av bergmasseskadorna uppkomna vid bryningen. Ett enkelt bi-linjär samband föreslås vilket använder malmbredd och brytningsdjup för att uppskatta den slutgiltiga utbredningen av skadezonen i bergmassan för varje brytningssteg, och i förlängningen begräsningen av senare uppkommande infrastrukturskador. Avhandlingen avslutas med rekommendationer för fortsatt arbete samt framtida forskningspotential.
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Schmid, Thomas. "Slot allocation at European airports." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ64302.pdf.
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Vellala, Manoj. "Stack Composition for SILO Architecture." NCSU, 2008. http://www.lib.ncsu.edu/theses/available/etd-03212008-153547/.
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SILO is a new internetworking architecture that represents a significant departure from current philosophy and practice. The architecture consists of building blocks of fine-grain functionality, explicit support for combining elemental blocks to accomplish highly configurable complex communication tasks, and control elements to facilitate (what is currently referred to as) cross-layer interactions. It takes a holistic view of network design, allowing applications to work synergistically with the network architecture and physical layers so as to meet the application's needs within resource availability constraints. The SILO research advocates a non-layered architecture based on silos of services assembled on demand and specific to an application and network environment. With the goal to facilitate what in today's layered architecture is referred to as ``cross-laye' interactions, in a manner that meets the exact user requirements and optimizes performance, the main focus of this research work is on developing mechanisms to optimize the construction of SILOs (stack of services) in a manner that takes into account service specific constraints, current network conditions and user policies.