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1

Singh, Shruti, Sara Z. Khan, Bhakti Patel, Rammohan Gumpeni, Sameer Verma, and Arunabh Talwar. "Slow vital capacity." International Journal of Advances in Medicine 8, no. 1 (2020): 144. http://dx.doi.org/10.18203/2349-3933.ijam20205488.

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Forced vital capacity (FVC) and slow vital capacity (SVC) are non-invasive tests of respiratory function. Although FVC has been extensively studied and is used in most PFT (pulmonary function test) labs, SVC can also be used in clinical practice as it is a more comfortable and convenient test to perform. SVC-based diagnostic criteria can lead to earlier detection of obstructive lung disease. In contrast to FVC, SVC is less affected by respiratory muscle fatigue, airflow patency, expiratory muscle weakness and air leakage making it an appropriate test of respiratory function in patients of amyotrophic lateral sclerosis (ALS) and other neuromuscular disorders. As respiratory insufficiency is the major cause of mortality in ALS patients, regular SVC measurement provides the respiratory functional status, so that early treatment can be started which improves the survival and quality of life in these patients. The purpose of this article is to highlight the importance of considering SVC in clinical practice.
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2

Chhabra, S. K. "Forced Vital Capacity, Slow Vital Capacity, or Inspiratory Vital Capacity: Which Is the Best Measure of Vital Capacity?" Journal of Asthma 35, no. 4 (1998): 361–65. http://dx.doi.org/10.3109/02770909809075669.

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3

Alberto de Castro Pereira, Carlos. "Difference between slow vital capacity and forced vital capacity in the diagnosis of airflow limitation." Jornal Brasileiro de Pneumologia 46, no. 2 (2020): e20200060-e20200060. http://dx.doi.org/10.36416/1806-3756/e20200060.

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4

Cohen, Judith, Dirkje S. Postma, Karin Vink-Klooster, et al. "FVC to Slow Inspiratory Vital Capacity Ratio." Chest 132, no. 4 (2007): 1198–203. http://dx.doi.org/10.1378/chest.06-2763.

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5

Huprikar, Nikhil, Valerie Bedsole, Tyson Sjulin, Michael Morris, and Andrew Skabelund. "An Evaluation of Slow Vital Capacity and Forced Vital Capacity Difference in Referred Patient Cohort." Chest 152, no. 4 (2017): A955. http://dx.doi.org/10.1016/j.chest.2017.08.990.

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6

Kang, Tae-Wook, and Jae-Seok Lee. "Effect of the Diaphragm Release Technique for a Diaphragmatic Mobility and Slow Vital Capacity." KOREAN ACADEMY OF CARDIORESPIRATORY PHYSICAL THERAPY 11, no. 2 (2023): 21–26. http://dx.doi.org/10.32337/kacpt.2023.11.2.21.

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Purpose: The purpose of this study was to investigate the immediate effect of diaphragm release technique applied to healthy adults on diaphragmatic mobility and slow vital capacity.
 Methods: This study included 21 healthy participants (13 males and 8 females). The participants performed exercises 10 times in 1 set diaphragm release technique, with a total of 3 sets. Before and after the intervention of the diaphragm release technique, diaphragmatic mobility was assessed using ultrasound, and slow vital capacity was evaluated using a portable digital spirometry device.
 Results: After the diaphragm release technique intervention, diaphragmatic mobility significantly increased in quiet breathing and deep breathing. In the case of slow vital capacity, only vital capacity increased significantly.
 Conclusion: Diaphragmatic mobility and slow vital capacity were affected by the diaphragm release technique, and it is believed that the diaphragm release technique will be useful as an intervention method in order to improve respiratory function.
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7

Han, Dongwook, Nayoon Yoon, Yeongran Jeong, Misook Ha, and Kunwoo Nam. "Effects of cervical self-stretching on slow vital capacity." Journal of Physical Therapy Science 27, no. 7 (2015): 2361–63. http://dx.doi.org/10.1589/jpts.27.2361.

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8

Lee, Juncheol, Sehee Hwang, Seungim Han, and Dongwook Han. "Effects of stretching the scalene muscles on slow vital capacity." Journal of Physical Therapy Science 28, no. 6 (2016): 1825–28. http://dx.doi.org/10.1589/jpts.28.1825.

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9

Nortje, Andre. "The Value of the Slow Vital Capacity in Diagnosing COPD." African Journal of Thoracic and Critical Care Medicine 27, no. 3 (2021): 127. http://dx.doi.org/10.7196/ajtccm.2021.v27i3.165.

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10

Calvo, Andrea, Rosario Vasta, Cristina Moglia, et al. "Prognostic role of slow vital capacity in amyotrophic lateral sclerosis." Journal of Neurology 267, no. 6 (2020): 1615–21. http://dx.doi.org/10.1007/s00415-020-09751-1.

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11

Lee, Jae-Seok, Dong-Wook Han, and Tae-Wook Kang. "Correlation between the Diaphragmatic Contraction Pressure and the Slow Vital Capacity." Journal of The Korean Society of Physical Medicine 14, no. 3 (2019): 47–53. http://dx.doi.org/10.13066/kspm.2019.14.3.47.

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12

Barros, Ana Raquel Goncalves de, Margarida Batista Pires, and Nuno Miguel Ferreira Raposo. "Importance of slow vital capacity in the detection of airway obstruction." Jornal Brasileiro de Pneumologia 39, no. 3 (2013): 317–22. http://dx.doi.org/10.1590/s1806-37132013000300008.

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OBJECTIVE: To investigate the presence of airway obstruction by determining the FEV1/FVC and FEV1/slow vital capacity (SVC) ratios. METHODS: This was a quantitative, retrospective cross-sectional study. The sample comprised 1,084 individuals who underwent spirometry and plethysmography in a central hospital in Lisbon, Portugal. The study sample was stratified into six groups, by pulmonary function. RESULTS: The analysis of the FEV1/FVC ratio revealed the presence of airway obstruction in 476 individuals (43.9%), compared with 566 individuals (52.2%) for the analysis of the FEV1/SVC ratio. In the airway obstruction, airway obstruction plus lung hyperinflation, and mixed pattern groups, the difference between SVC and FVC (SVC − FVC) was statistically superior to that in the normal pulmonary function, reduced FEF, and restrictive lung disease groups. The SVC − FVC parameter showed a significant negative correlation with FEV1 (in % of the predicted value) only in the airway obstruction plus lung hyperinflation group. CONCLUSIONS: The FEV1/SVC ratio detected the presence of airway obstruction in more individuals than did the FEV1/FVC ratio; that is, the FEV1/SVC ratio is more reliable than is the FEV1/FVC ratio in the detection of obstructive pulmonary disease.
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13

Mankar, Komal, Tushar Mankar, and Ramu Dindugala. "Significance of slow vital capacity, difference between slow and forced vital capacity, ratio of FEV1/SVC with increasing age and BMI in healthy males and females." National Journal of Physiology, Pharmacy and Pharmacology 14, no. 4 (2024): 1. http://dx.doi.org/10.5455/njppp.2024.14.02068202428022024.

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Background: The slow vital capacity (SVC), forced vital capacity (FVC) difference, and forced expiratory volume in one second (FEV1)/SVC ratio are crucial for understanding respiratory health, especially in mild airway obstruction. These parameters are more reliable than traditional measures and are influenced by age and body mass index (BMI). Investigating their relationship can improve diagnostic accuracy and health-care interventions. Aims and Objectives: (i) To record peak expiratory flow rate (PEFR), FVC, FEV1 of expiration, FEV1/FVC ratio, forced expiratory flow rate (FEF25-75%), mean forced expiratory flow rate from 0.2 to 1.2 l of volume expired (FEF.2-1.2), SVC, and find the difference between SVC and FVC, ratio of FEV1/SVC. (ii) To correlate SVC, SVC-FVC, FEV1/SVC, and other pulmonary function tests (PFTs) with age, gender, and BMI emphasizing their importance in detecting airway obstruction. (iii) To assess these known indicators of airflow obstruction in healthy individuals to gain knowledge of changing lung health with respect to advancing age, gender, and BMI. Materials and Methods: The study included 200 individuals, comprising both men and women aged between 18 and 60 years, who were in good health. The sample was divided into five age groups, and participants were classified into categories of underweight, normal weight, overweight, and obese based on their BMI. Standard procedures were employed to record anthropometric measurements. PEFR was measured using Wright’s peak flow meter, whereas FVC, FEV1, FEV1/FVC ratio, forced expiratory flow between 25 and 75% of FVC (FEF25-75%), forced expiratory flow at 2-1.2 l (FEF.2-1.2), and SVC were assessed using an expirograph (Helios 401, RMS, India). Adequate statistical analysis was conducted on the gathered data. Results: There was a highly significant difference in the means of SVC, SVC-FVC, FEV1/SVC, and other PFTs (P < 0.000) over the five age groups by ANOVA and a significant difference between younger and older age groups analyzed by post hoc test. It also showed a highly significant difference in the mean values of SVC, FEV1/SVC, and other PFTs over the categories of BMI and a significant difference between normal and obese groups by multiple comparisons. A small increase in mean values of SVC-FVC was seen in overweight, obese, and underweight compared to the normal BMI group. Females showed reduced mean values of SVC, FEV1/SVC, and other PFTs compared to males. (P < 0.000). The mean value of SVC-FVC in females is greater than in males (P < 0.01), which suggest that the tendency for airway obstruction may be greater in women compared to men due to smaller airway diameter and diffusion surface. PEFR, FVC, FEV1, FEV1/FVC, FEF25-75%, FEF.2-1.2, SVC, and FEV1/SVC were negatively correlated with age. SVC-FVC was positively correlated with age (r = 0.338, P < 0.000). There was a negative correlation between PEFR, FVC, FEV1, FEF25-75%, FEF.2-1.2, SVC, and BMI. Conclusions: PFT serves as a crucial diagnostic tool in assessing respiratory health, with parameters such as FVC and FEV1 commonly utilized. However, SVC is gaining recognition for its nuanced insights into lung function. This article delves into the significance of SVC, highlights the differences between SVC and FVC, and explores the relationship between FEV1/SVC ratio, age, and BMI in healthy individuals. The current research was undertaken due to a scarcity of existing studies and demonstrated that SVC, the ratio of FEV1/SVC, and other PFTs diminish with age progression and increasing BMI. In addition, females exhibited decreased lung function, with a greater disparity between SVC and FVC than males.
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14

Subramanian, Venkata S., and Sangeetha Partha Sarathy. "To Correlate the Difference between Slow Vital Capacity and Forced Vital Capacity with the Severity of Chronic Obstructive Pulmonary Disease." International Journal of Physiology 4, no. 1 (2016): 116. http://dx.doi.org/10.5958/2320-608x.2016.00023.8.

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15

Supriwandani, Heru, Mardiyono Mardiyono, and Warijan Warijan. "SLOW DEEP PURSED-LIPS BREATHING EXERCISE ON VITAL LUNG CAPACITY IN POST-EXTUBATION PATIENTS IN THE INTENSIVE CARE UNIT." Belitung Nursing Journal 4, no. 1 (2018): 58–67. http://dx.doi.org/10.33546/bnj.127.

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Background: The incidence of respiratory failure reaches 20-75 cases per 100,000 population each year with mortality rate reaching 30-50%. Provision of respiratory assistance with mechanical ventilation is provided with an indication of the inability of the respiratory function for optimal alveolar ventilation. Efforts to restore lung oxygenation ventilation function can be done through breathing exercises and are expected to improve pulmonary ventilation function.Objective: This study was to examine the effectiveness of the modified Slow Deep Pursed-Lips Breathing Exercise (SDPLBE) on vital lung capacity in patients post-extubation of mechanical ventilators.Methods: This was a true experimental study with pretest posttest control group design. Thirty respondents were selected using stratified random sampling, with 15 samples assigned in the experiment and control group. Peak flow meter was used to measure vital lung capacity (FEV1 value). Repeated measures ANOVA was used for data analysis.Results: There was a significant difference on respondent's vital lung capacity after given slow deep pursed lips-breathing exercise at each session from session 1 to session 8 (p=0.000). However both groups were not yet able to achieve ≥ 400 mL / min, but the experiment group was closer to the normal value (369) than the control group.Conclusion: Slow Deep Pursed-Lips Breathing Exercise may increase vital lung capacity in patients post-extubation of mechanical ventilator.
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16

Huprikar, Nikhil A., Andrew J. Skabelund, Valerie G. Bedsole, et al. "Comparison of Forced and Slow Vital Capacity Maneuvers in Defining Airway Obstruction." Respiratory Care 64, no. 7 (2019): 786–92. http://dx.doi.org/10.4187/respcare.06419.

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17

Han, Dong-Wook. "The Relationship between Muscular Endurance of Respiratory Muscles and Slow Vital Capacity." KOREAN ACADEMY OF CARDIORESPIRATORY PHYSICAL THERAPY 8, no. 1 (2020): 1–5. http://dx.doi.org/10.32337/kacpt.2020.8.1.1.

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18

PISTELLI, FRANCESCO, MATTEO BOTTAI, GIOVANNI VIEGI, et al. "Smooth Reference Equations for Slow Vital Capacity and Flow–Volume Curve Indexes." American Journal of Respiratory and Critical Care Medicine 161, no. 3 (2000): 899–905. http://dx.doi.org/10.1164/ajrccm.161.3.9906006.

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19

Nathan, S. D., H. Kim, S. Guthrie, et al. "Clinical Implications of Slow Vital Capacity in Patients with Idiopathic Pulmonary Fibrosis." American Journal of Respiratory and Critical Care Medicine 211, Abstracts (2025): A1754. https://doi.org/10.1164/ajrccm.2025.211.abstracts.a1754.

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20

Pinto, Susana, and Mamede de Carvalho. "Correlation between Forced Vital Capacity and Slow Vital Capacity for the assessment of respiratory involvement in Amyotrophic Lateral Sclerosis: a prospective study." Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 18, no. 1-2 (2016): 86–91. http://dx.doi.org/10.1080/21678421.2016.1249486.

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21

Anthraper, Jyothy, and Dr Reeny Roy. "Pulmonary Function Test of Forced Vital Capacity and Slow Vital Capacity Using Spirometry in Young Adults With Respect to Body Mass Index: A Normative Study." Volume 5 - 2020, Issue 8 - August 5, no. 8 (2020): 1094–111. http://dx.doi.org/10.38124/ijisrt20aug608.

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Objectives: To determine the effect of Age, Gender and its correlation on pulmonary functions of Forced Vital Capacity and Slow Vital Capacity in Group I (18-24 years) and Group II (25-30 years) with respect to Body Mass Index.  Methodology: Sixty healthy adults between 18-30 years were included in the study. Participants were subdivided into Group I (18 to 24 years) and Group II (25 to 30 years) each group having 15 males and 15 females. The parameters considered were expiratory reserve volume, tidal volume, inspiratory capacity, forced vital capacity and slow vital capacity. Spirometer RMS HELIOS 401 was used. Procedures were explained to each participant; best values from 3 maneuvers were documented and were subjected to analysis.  Results: It is noticed a significant difference in various parameters of pulmonary function. As age increases there was an increase in body mass index and the lung volume also increased. Overall males had higher pulmonary function compared to females, males in Group II (25-30 years) was better compared to males in Group I (18-24 years). With an increase in body mass index, pulmonary function was increased in males compared to females. Age, gender, age, and gender interaction effect with respect to Body Mass Index was seen.  Conclusion: Values obtained can be used as reference standard for estimation of lung volume for age group 18-30 years. In future, Spirometry can be used as a clinical assessment and management tool in the field of speech language pathology, by modifying respiratory patterns to control lung volumes, phonations and the flow of speech.
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22

Aelony, Yossef, and Marco Aurélio de Valois Correia Junior. "Correlation between slow vital capacity and the maximum phonation time in healthy adults." Revista CEFAC 18, no. 5 (2016): 1031–34. http://dx.doi.org/10.1590/1982-021620161856016.

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23

Pistelli, Francesco. "ERRATUM: SMOOTH REFERENCE EQUATIONS FOR SLOW VITAL CAPACITY AND FLOW–VOLUME CURVE INDEXES." American Journal of Respiratory and Critical Care Medicine 164, no. 9 (2001): 1740. http://dx.doi.org/10.1164/ajrccm.164.9.correspondence_a.

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24

Gibson, H. N., J. Roomi, and M. J. Connolly. "Slow Vital Capacity in Assessment of Reversibility of Airways Obstruction in Elderly Patients." Age and Ageing 24, suppl 2 (1995): P12. http://dx.doi.org/10.1093/ageing/24.suppl_2.p12-b.

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25

Yamada, Tatsuji, Akiomi Inoue, Kosuke Mafune, Hisanori Hiro, and Shoji Nagata. "Recovery of Percent Vital Capacity by Breathing Training in Patients With Panic Disorder and Impaired Diaphragmatic Breathing." Behavior Modification 41, no. 5 (2017): 665–82. http://dx.doi.org/10.1177/0145445517711436.

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Slow diaphragmatic breathing is one of the therapeutic methods used in behavioral therapy for panic disorder. In practice, we have noticed that some of these patients could not perform diaphragmatic breathing and their percent vital capacity was initially reduced but could be recovered through breathing training. We conducted a comparative study with healthy controls to investigate the relationship between diaphragmatic breathing ability and percent vital capacity in patients with panic disorder. Our findings suggest that percent vital capacity in patients with impaired diaphragmatic breathing was significantly reduced compared with those with normal diaphragmatic breathing and that diaphragmatic breathing could be restored by breathing training. Percent vital capacity of the healthy controls was equivalent to that of the patients who had completed breathing training. This article provides preliminary findings regarding reduced vital capacity in relation to abnormal respiratory movements found in patients with panic disorder, potentially offering alternative perspectives for verifying the significance of breathing training for panic disorder.
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26

Postma, DS, I. Peters, EJ Steenhuis, and HJ Sluiter. "Moderately severe chronic airflow obstruction. Can corticosteroids slow down obstruction?" European Respiratory Journal 1, no. 1 (1988): 22–26. http://dx.doi.org/10.1183/09031936.93.01010022.

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In a former study in patients with severe chronic airflow obstruction (CAO), (forced expiratory volume in one second (FEV1) ranging from 350-910 ml), we concluded that daily oral corticosteroids might slow down the progression of disease. The results of the present long-term (14-20 yr) study on 139 non-allergic patients with less severe CAO (FEV1 greater than or equal to 1200 ml, FEV1 as a percentage of vital capacity (FEV1%VC) 40-55%) confirm and extend our former observations. Four patterns of the course of FEV1 and inspiratory vital capacity (VC) in time were recognized: 1) linear decrease; 2) no change; 3) initial increase, followed by decrease; 4) initial decrease, followed by increase. Groups 1 and 3 had a higher functional residual capacity as a percentage of total lung capacity (FRC%TLC) as compared to group 2 and 4; the work of breathing was lower in group 2 than in the other three groups. Otherwise the initial 82 parameters, including the degree of reversibility of airflow obstruction and smoking habits were comparable in the four groups. The four patterns of FEV1 showed a strong association with the long-term use of prednisolone. When oral prednisolone was instituted or increased to a dose of at least 10 mg/day continuously, FEV1 either remained constant, decreased more slowly or even increased over many years of follow-up. When the oral dose was diminished to below 10 mg/day, FEV1 decreased.(ABSTRACT TRUNCATED AT 250 WORDS)
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27

Lee, Juncheol, and Dongwook Han. "Effect of the trunk forward bending angle in sitting position on slow vital capacity." Journal of Physical Therapy Science 29, no. 12 (2017): 2220–23. http://dx.doi.org/10.1589/jpts.29.2220.

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28

Jackson, Carlayne, Mamede De Carvalho, Angela Genge, et al. "Relationships between slow vital capacity and measures of respiratory function on the ALSFRS-R." Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 19, no. 7-8 (2018): 506–12. http://dx.doi.org/10.1080/21678421.2018.1497658.

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29

Gove, R. I., J. Shepherd, and P. S. Burge. "Variability and reversibility of the slow and forced vital capacity in chronic airflow obstruction." British Journal of Diseases of the Chest 81 (January 1987): 182–85. http://dx.doi.org/10.1016/0007-0971(87)90137-9.

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30

Han, Dong-Wook. "The Effects of Curl-up Exercise with Abdominal Hollowing on Slow Vital Capacity (SVC." KOREAN ACADEMY OF CARDIORESPIRATORY PHYSICAL THERAPY 12, no. 3 (2024): 63–68. https://doi.org/10.32337/kacpt.2024.12.3.63.

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31

Olson, Thomas P., Theodore A. Wilson, Bruce D. Johnson, and Robert E. Hyatt. "History dependence of vital capacity in constricted lungs." Journal of Applied Physiology 109, no. 1 (2010): 121–25. http://dx.doi.org/10.1152/japplphysiol.01365.2009.

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Measurements of dynamic force-length behavior of maximally activated strips of smooth muscle during oscillatory length changes show that force decreases well below the isometric force during the shortening phase of the oscillation. The magnitude of the decrease depends on the rate of shortening; for slower shortening, the decrease is smaller and force is larger. Modeling of expiratory flow, based on these data, predicts that vital capacity in constricted lungs depends on the rate of expiration. In maximally constricted lungs, forced vital capacity (FVC) is predicted to be 16% smaller than control, and vital capacity for a very slow expiration (SVC), 31% less than control. These predictions were tested by measuring FVC and SVC in constricted normal subjects. In the first group of 9 subjects, four maneuvers were made following the delivery of two doses of methacholine in the order: SVC, FVC, FVC, SVC. In a second group of 11 subjects, two maneuvers were performed at each dose in the order: FVC, SVC. At the highest dose of methacholine, FVC for both trials in group 1 and for the one trial in group 2 were all ∼13% less than control, a slightly smaller decrease than predicted. SVC for the 1st trial in group 1 was 27% less than control, also slightly smaller than predicted. The difference between FVC and SVC for this trial, 13%, was close to the predicted difference of 15%. However, SVC for the 2nd trial in group 1 (preceded by 3 vital capacity maneuvers) and for group 2 (preceded by 1) were no different from FVC. We conclude that vital capacity in constricted lungs depends on the dynamic force-length properties of smooth muscle and that the history dependence of the dynamic properties of smooth muscle is more complicated than has been inferred from oscillatory force-length behavior.
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32

Frerichs, Inéz, Taras Dudykevych, José Hinz, Marc Bodenstein, Günter Hahn, and Gerhard Hellige. "Gravity effects on regional lung ventilation determined by functional EIT during parabolic flights." Journal of Applied Physiology 91, no. 1 (2001): 39–50. http://dx.doi.org/10.1152/jappl.2001.91.1.39.

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Gravity-dependent changes of regional lung function were studied during normogravity, hypergravity, and microgravity induced by parabolic flights. Seven healthy subjects were followed in the right lateral and supine postures during tidal breathing, forced vital capacity, and slow expiratory vital capacity maneuvers. Regional 1) lung ventilation, 2) lung volumes, and 3) lung emptying behavior were studied in a transverse thoracic plane by functional electrical impedance tomography (EIT). The results showed gravity-dependent changes of regional lung ventilation parameters. A significant effect of gravity on regional functional residual capacity with a rapid lung volume redistribution during the gravity transition phases was established. The most homogeneous functional residual capacity distribution was found at microgravity. During vital capacity and forced vital capacity in the right lateral posture, the decrease in lung volume on expiration was larger in the right lung region at all gravity phases. During tidal breathing, the differences in ventilation magnitudes between the right and left lung regions were not significant in either posture or gravity phase. A significant nonlinearity of lung emptying was determined at normogravity and hypergravity. The pattern of lung emptying was homogeneous during microgravity.
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33

Patel, Devangiben Dilipbhai, Anwar Tausif, Singh Abhilasha, and Kamendu Abhishek. "Evaluation of Forced Vital Capacity (Fvc) and Slow Vital Capacity (Svc) in Suspected Patients of Obstructive Airway Disease Visiting Tertiary Care Hospital In Southern Bihar." International Journal of Pharmaceutical and Clinical Research 14, no. 10 (2022): 284–88. https://doi.org/10.5281/zenodo.13291650.

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<strong>Background:&nbsp;</strong>Forced expiratory volume in 1 second (FEV1) to forced vital capacity ratio (FVC) is being used to diagnose the obstructive lung diseases. Forced manoeuvre (FVC) or relaxed/slow manoeuvre (SVC) can be used to determine vital capacity (VC). In healthy individuals the difference between SVC and FVC (SVC-FVC) is minimal whereas in the presence of airway obstruction this difference will become significant. The present study was done with the objective to detect and compare the airway obstruction by determining the FEV1/FVC and FEV1/ SVC ratios.&nbsp;<strong>Methods:&nbsp;</strong>This was a prospective cross-sectional study done at Narayan medical college and hospital Sasaram Bihar during the period from January 2022 to June 2022 among the patients presenting with symptoms of obstructive airway disease. The sample comprised of 350 patients who underwent spirometry according to standard of ATS/ERS guidelines. As per the criteria, the patients are classified into four groups, by spirometry.&nbsp;<strong>Results:&nbsp;</strong>The analysis of FEV1/FVC revealed the presence of airway obstruction in 130 (37%) individuals compared to 165 (46%) individuals by the analysis of Fev1/SVC ratio. In the obstruction and mixed groups, the difference in vital capacity SVC &ndash; FVC is statistically superior (p&lt;0.05) when compared to normal and restriction groups.&nbsp;<strong>Conclusions:&nbsp;</strong>The FEV1/SVC ratio detected the presence of airway obstruction in more individuals than did FEV1/FVC ratio and hence FEV1/SVC considered as more reliable factor in the detection of obstructive airway diseases. &nbsp; &nbsp; &nbsp;
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34

Allen, S. C., C. Charlton, W. Backen, M. Warwick-Sanders, and P. Yeung. "Performing slow vital capacity in older people with and without cognitive impairment -- is it useful?" Age and Ageing 39, no. 5 (2010): 588–91. http://dx.doi.org/10.1093/ageing/afq084.

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35

Cotton, DJ, JT Mink, and BL Graham. "Detection of Peripheral Ventilation Inhomogeneity in Smokers." Canadian Respiratory Journal 4, no. 1 (1997): 27–33. http://dx.doi.org/10.1155/1997/234268.

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BACKGROUND: In smokers, ‘small airways’ narrowing alters the conventional, vital capacity single breath washout (SBWVC). Although, in some studies, the test predicts smokers at risk of developing chronic airflow limitation, its wide variability partly explains its poor positive predictive value. An alternative explanation for the test’s poor predictive value is that it may not accurately reflect small airway narrowing in the lung periphery.OBJECTIVE: To determine whether smoke-induced increases in ventilation inhomogeneity differ between SBWVCmanoeuvres, which augment topographical (apex-to-base) ventilation inhomogeneity, and submaximal manoeuvres (SBWSM), which enhance peripheral ventilation inhomogeneity.STUDY GROUP AND DESIGN: Cross-sectional study of 21 current smokers and 21 nonsmokers with similar age and forced expiratory volumes in 1 s (FEV1).METHODS: Smokers and nonsmokers performed SBW with either slow vital capacity inhalation and exhalation of test gas without breath holding (SBWVC); or slow inhalation of test gas from functional residual capacity to one-half inspiratory capacity and, after 0 s or 10 s of breath holding, slow exhalation to residual volume (SBWSM). For all SBW the normalized phase III helium slope (Sn), closing capacity (CC) as a percentage of total lung capacity (TLC) and mixing efficiency (Emix) were measured.RESULTS: For SBWVC, smoking had no effect on Snor Emix. However, CC/TLC was increased in smokers (P&lt;0.05), but did not correlate with pack years or age. For SBWSM, smoking had no effect on Emixor CC/TLC, but resulted in a steeper Sn(P &lt;0.05), which decreased more with breath holding (P&lt;0.01) and correlated with pack years (P&lt;0.05) at 0 s but not 10 s of breath holding.CONCLUSIONS: In smokers with normal FEV1, SBWSM manoeuvres reveal increases in breath hold time-dependent ventilation inhomogeneity in the lung periphery, not detected by conventional SBWVC.
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Aono, Yuya, Yutaro Nakamura, Masato Kono, et al. "Prognostic significance of forced vital capacity decline prior to and following antifibrotic therapy in idiopathic pulmonary fibrosis." Therapeutic Advances in Respiratory Disease 14 (January 2020): 175346662095378. http://dx.doi.org/10.1177/1753466620953783.

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Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease (ILD). Currently, two antifibrotic drugs are available for reducing forced vital capacity (FVC) decline in IPF. However, many pulmonologists wait before initiating treatment, especially when IPF patients have stable disease. This study aimed to investigate the impact on survival outcome of FVC decline and a slow rate of FVC decline prior to and following treatment with these two antifibrotic drugs. Methods: Out of the 235 IPF patients treated with antifibrotic therapy that were screened, 105 cases were eligible, who then underwent physiological evaluation at 6 months prior to and following antifibrotic therapy. Clinical characteristics and prognostic outcomes were compared among groups, and prognostic factors were evaluated using a Cox proportional hazards analysis. Results: In terms of %FVC decline prior to the therapy and a slow rate of FVC decline, there was no significant difference between stable and worsened groups and responder and non-responder groups, respectively. On the other hand, in terms of %FVC decline (decline &gt;5%) following antifibrotic therapy, the stable/improved group had significantly better prognosis than the worsened group. Prognostic analysis revealed that a stable/improved status following antifibrotic therapy [HR: 0.35 (0.15–0.87)] was significantly associated with a better prognosis. Conclusions: Concerning the FVC decline prior to and following antifibrotic therapy and a slow rate of FVC decline, only the FVC decline following the therapy is associated with a greater survival outcome. An early treatment decision may thus be beneficial for IPF. The reviews of this paper are available via the supplemental material section.
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Lambert, Rodney K., and Theodore A. Wilson. "Smooth muscle dynamics and maximal expiratory flow in asthma." Journal of Applied Physiology 99, no. 5 (2005): 1885–90. http://dx.doi.org/10.1152/japplphysiol.00450.2005.

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A computational model for maximal expiratory flow in constricted lungs is presented. The model was constructed by combining a previous computational model for maximal expiratory flow in normal lungs and a previous mathematical model for smooth muscle dynamics. Maximal expiratory flow-volume curves were computed for different levels of smooth muscle activation. The computed maximal expiratory flow-volume curves agree with data in the literature on flow in constricted nonasthmatic subjects. In the model, muscle force during expiration depends on the balance between the decrease in force that accompanies muscle shortening and the recovery of force that occurs during the time course of expiration, and the computed increase in residual volume (RV) depends on the magnitude of force recovery. The model was also used to calculate RV for a vital capacity maneuver with a slow rate of expiration, and RV was found to be further increased for this maneuver. We propose that the measurement of RV for a vital capacity maneuver with a slow rate of expiration would provide a more sensitive test of smooth muscle activation than the measurement of maximal expiratory flow.
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Cocconcelli, Elisabetta, Elisabetta Balestro, Davide Biondini, et al. "High-Resolution Computed Tomography (HRCT) Reflects Disease Progression in Patients with Idiopathic Pulmonary Fibrosis (IPF): Relationship with Lung Pathology." Journal of Clinical Medicine 8, no. 3 (2019): 399. http://dx.doi.org/10.3390/jcm8030399.

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High-Resolution Computed Tomography (HRCT) plays a central role in diagnosing Idiopathic Pulmonary Fibrosis (IPF) while its role in monitoring disease progression is not clearly defined. Given the variable clinical course of the disease, we evaluated whether HRCT abnormalities predict disease behavior and correlate with functional decline in untreated IPF patients. Forty-nine patients (with HRCT1) were functionally categorized as rapid or slow progressors. Twenty-one had a second HRCT2. Thirteen patients underwent lung transplantation and pathology was quantified. HRCT Alveolar (AS) and Interstitial Scores (IS) were assessed and correlated with Forced Vital Capacity (FVC) decline between HRCT1 and HRCT2. At baseline, AS was greater in rapids than in slows, while IS was similar in the two groups. In the 21 subjects with HRCT2, IS increased over time in both slows and rapids, while AS increased only in rapids. The IS change from HRCT1 to HRCT2 normalized per month correlated with FVC decline/month in the whole population, but the change in AS did not. In the 13 patients with pathology, the number of total lymphocytes was higher in rapids than in slows and correlated with AS. Quantitative estimation of HRCTs AS and IS reflects the distinct clinical and pathological behavior of slow and rapid decliners. Furthermore, AS, which reflects the immune/inflammatory infiltrate in lung tissue, could be a useful tool to differentiate rapid from slow progressors at presentation.
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39

Glanville, Allan R., Richard A. Yeend, James Theodore, and Eugene D. Robin. "Effect of single respiratory manoeuvres on specific airway conductance in heart–lung transplant recipients." Clinical Science 74, no. 3 (1988): 311–17. http://dx.doi.org/10.1042/cs0740311.

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1. The time course and magnitude of the effect of single slow and rapid respiratory manoeuvres on specific airway conductance (sGaw) was assessed in seven normal control subjects and in seven heart–lung transplant (HLT) recipients before and after experimentally induced bronchoconstriction. 2. Neither full inspiration, full exhalation nor vital capacity manoeuvres significantly altered sGaw in normal controls or HLT recipients under baseline conditions despite the presence of hyper-responsiveness to methacholine (MC) in the latter group. 3. After induced bronchoconstriction, single slow and rapid inspirations to total lung capacity transiently abolished or attenuated the bronchoconstriction in normal controls. This effect was absent in the HLT recipients. 4. In HLT recipients, the combination of hyper-responsiveness to MC, the absence of bronchoconstriction with respiratory manoeuvres and the absence of significant bronchodilatation after deep inspiration suggest lack of normal pulmonary innervation.
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40

Ferdousi, Sultana, KN Afreen, and S. Algin. "Effect of Slow Breathing Exercise on Forced Vital Capacity and Forced Expiratory Volume in Patients with Major Depressive Disorder." Bangladesh Medical Research Council Bulletin 44, no. 3 (2019): 118–23. http://dx.doi.org/10.3329/bmrcb.v44i3.39934.

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Background: Major Depressive Disorder (MDD) is associated with depressed lung function. Regular practice of slow breathing exercise (SBE) significantly improved lung function in healthy adult subjects. This study aimed to observe the effect of SBE and anti-depressive medication on forced vital capacity (FVC), forced expiratory volume in 1st second (FEV1) and FEV1/FVC% in major depressive disorder&#x0D; Methods: This prospective intervention study was carried out in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka on 60 newly diagnosed MDD female patients aged 20 to 50 years. They were enrolled from the Department of Psychiatry of BSMMU. Age, body mass index (BMI), socioeconomic status and occupation matched 30 apparently healthy females were controls. MDD patients were subdivided into 2 groups. Thirty (30) patients were intervened with slow breathing exercise (SBE) along with anti-depressive medication whereas 30 patients were under antidepressive medication only. All patients were studied at baseline and at the end of 3 months of intervention. FVC, FEV1 and FEV1/FVC% were assessed by a portable digital spirometer. To see the difference independent sample ‘t’ test and paired sample ‘t’test were used as appropriate.&#x0D; Results: FVC, FEV1, FEV1/FVC% were significantly lower (p≤0.001) in all MDD patients at baseline than control. After 3 months of follow-up these values were found significantly improved in patients with slow breathing but no improvement was found in patients treated with only anti-depressive medication. Moreover, these values were found significantly higher in patients with SBE than those of patients under medication only after 3 months of follow-up.&#x0D; Conclusion: Based on the study findings, it may be concluded that SBE may significantly improve depressed lung function of MDD patients whereas anti-depressive medication had no impact on reduced lung function associated with MDD.&#x0D; Bangladesh Med Res Counc Bull 2018; 44: 118-123
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Guimarães-Costa, Raquel, Thomas Similowski, Isabelle Rivals, et al. "Human diaphragm atrophy in amyotrophic lateral sclerosis is not predicted by routine respiratory measures." European Respiratory Journal 53, no. 2 (2019): 1801749. http://dx.doi.org/10.1183/13993003.01749-2018.

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Amyotrophic lateral sclerosis (ALS) patients show progressive respiratory muscle weakness leading to death from respiratory failure. However, there are no data on diaphragm histological changes in ALS patients and how they correlate with routine respiratory measurements.We collected 39 diaphragm biopsies concomitantly with laparoscopic insertion of intradiaphragmatic electrodes during a randomised controlled trial evaluating early diaphragm pacing in ALS (https://clinicaltrials.gov; NCT01583088). Myofibre type, size and distribution were evaluated by immunofluorescence microscopy and correlated with spirometry, respiratory muscle strength and phrenic nerve conduction parameters. The relationship between these variables and diaphragm atrophy was assessed using multivariate regression models.All patients exhibited significant slow- and fast-twitch diaphragmatic atrophy. Vital capacity (VC), maximal inspiratory pressure, sniff nasal inspiratory pressure (SNIP) and twitch transdiaphragmatic pressure did not correlate with the severity of diaphragm atrophy. Inspiratory capacity (IC) correlated modestly with slow-twitch myofibre atrophy. Supine fall in VC correlated weakly with fast-twitch myofibre atrophy. Multivariate analysis showed that IC, SNIP and functional residual capacity were independent predictors of slow-twitch diaphragmatic atrophy, but not fast-twitch atrophy.Routine respiratory tests are poor predictors of diaphragm structural changes. Improved detection of diaphragm atrophy is essential for clinical practice and for management of trials specifically targeting diaphragm muscle function.
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42

Cotton, DJ, JT Mink, and BL Graham. "Nonuniformity of Diffusing Capacity From Small Alveolar Gas Samples Is Increased in Smokers." Canadian Respiratory Journal 5, no. 2 (1998): 101–8. http://dx.doi.org/10.1155/1998/324920.

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BACKGROUND: Although centrilobular emphysema, and small airway, interstitial and alveoli inflammation can be detected pathologically in the lungs of smokers with relatively well preserved lung function, these changes are difficult to assess using available physiological tests. Because submaximal single breath washout (SBWSM) manoeuvres improve the detection of abnormalities in ventilation inhomogeneity in the lung periphery in smokers compared with traditional vital capacity manoeuvres, SBWSMmanoeuvres were used in this study to measure temporal differences in diffusing capacity using a rapid response carbon monoxide analyzer.OBJECTIVE: To determine whether abnormalities in the lung periphery can be detected in smokers with normal forced expired volumes in 1 s using the three-equation diffusing capacity (DLcoSB-3EQ) among small alveolar gas samples and whether the abnormalities correlate with increases in peripheral ventilation inhomogeneity.PARTICIPANTS AND DESIGN: Cross-sectional study in 21 smokers and 21 nonsmokers all with normal forced exhaled flow rates.METHODS: Both smokers and nonsmokers performed SBWSMmanoeuvres consisting of slow inhalation of test gas from functional residual capacity to one-half inspiratory capacity with either 0 or 10 s of breath holding and slow exhalation to residual volume (RV). They also performed conventional vital capacity single breath (SBWVC) manoeuvres consisting of slow inhalation of test gas from RV to total lung capacity and, without breath holding, slow exhalation to RV. DLcoSB-3EQ was calculated from the total alveolar gas sample. DLcoSB-3EQ was also calculated from four equal sequential, simulated aliquots of the total alveolar gas sample. DLcoSB-3EQ values from the four alveolar samples were normalized by expressing each as a percentge of DLcoSB-3EQ from the entire alveolar gas sample. An index of variation (DI) among the small-sample DLcoSB-3EQ values was correlated with the normalized phase III helium slope (Sn) and the mixing efficiency (Emix).RESULTS: For SBWSM, DIwas increased in smokers at 0 s of breath holding compared with nonsmokers, and correlated with age, smoking pack-years and Sn. The decrease in DIwith breath holding was greater in smokers and correlated with the change in Sn with breath holding. For SBWVCmanoeuvres, there were no differences due to smoking in Sn or Emix, but DIwas increased in smokers and correlated with age and smoking pack-years, but not with Sn.CONCLUSIONS: For SBWSMmanoeuvres the increase in DIin smokers correlated with breath hold time-dependent increases in Sn, suggesting that the changes in DIreflected the same structural alterations that caused increases in peripheral ventilation inhomogeneity. For SBWVCmanoeuvres, the increase in DIin smokers was not associated with changes in ventilation inhomogeneity, suggesting that the effect of smoking on DIduring this manoeuvre was due to smoke-related changes in alveolar capillary diffusion, rather than due solely to alterations in the distribution of ventilation.
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43

Filuk, R. B., and N. R. Anthonisen. "Changes in regional emptying sequence need not change maximum expiratory flow." Journal of Applied Physiology 60, no. 6 (1986): 1834–38. http://dx.doi.org/10.1152/jappl.1986.60.6.1834.

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Nine normal young men inhaled boluses of He at the onset of slow vital capacity (VC) inspirations. During the subsequent VC expirations, we measured expired flow, volume, and He concentrations. Expirations consisted of full or partial maximum expiratory flow-volume (MEFV) maneuvers. Full maneuvers were forced expirations from total lung capacity (TLC). Partial maneuvers were accomplished by expiring slowly from TLC to 70, 60, 50, and 40% VC and then initiating forced expiration. Expired He concentrations from full and partial maneuvers were compared with each other and with those resulting from slow expirations. At comparable volumes less than 50% VC, flow during partial and full MEFV maneuvers did not differ. Expired He concentrations were higher during partial maneuvers than during full ones; at the onset of partial maneuvers upper zone emptying predominated, whereas this was not the case at the same lung volumes during maneuvers initiated at TLC. We observed substantial differences in regional emptying sequence that did not influence maximum expiratory flow.
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44

Saint-Pierre, Mathieu, Jamil Ladha, Danilo C. Berton, et al. "Is the Slow Vital Capacity Clinically Useful to Uncover Airflow Limitation in Subjects With Preserved FEV1/FVC Ratio?" Chest 156, no. 3 (2019): 497–506. http://dx.doi.org/10.1016/j.chest.2019.02.001.

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45

Lee, Jin-Woo, and Dong-Wook Han. "Effect of the Evjenth-Hamberg Stretching for the Intercostal Muscles on Rib Cage Movement and Slow Vital Capacity." KOREAN ACADEMY OF CARDIORESPIRATORY PHYSICAL THERAPY 13, no. 1 (2025): 51–57. https://doi.org/10.32337/kacpt.2025.13.1.51.

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46

Yuan, Wei, Haoyan Wang, Qiu-Fen Xu, et al. "Difference Between Slow and Forced Vital Capacity in Patients With COPD: An Index of the Severity of Airflow limitation." Chest 144, no. 4 (2013): 688A. http://dx.doi.org/10.1378/chest.1699692.

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47

M., Saravanan, P. M. Ramesh, and K. Rajarajeswari. "Which is better among FEV1/FVC and FEV1/SVC in obstructive airway disease?" International Journal of Advances in Medicine 5, no. 6 (2018): 1328. http://dx.doi.org/10.18203/2349-3933.ijam20184195.

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Background: Forced expiratory volume in 1 second (FEV1) to forced vital capacity ratio (FVC) is being used to diagnose the obstructive lung diseases. Forced manoeuvre (FVC) or relaxed/slow manoeuvre (SVC) can be used to determine vital capacity (VC). In healthy individuals the difference between SVC and FVC (SVC-FVC) is minimal whereas in the presence of airway obstruction this difference will become significant. The present study was done with the objective to detect and compare the airway obstruction by determining the FEV1/FVC and FEV1/ SVC ratios.Methods: This was a prospective cross-sectional study done at OPD, Government Thiruvoteeswarar hospital of thoracic medicine/Kilpauk medical college during the period from September 2016 to February 2017among the patients presenting with symptoms of obstructive airway disease. The sample comprised of 353 patients who underwent spirometry according to standard of ATS/ERS guidelines. As per the criteria, the patients are classified into four groups, by spirometry.Results: The analysis of FEV1/FVC revealed the presence of airway obstruction in 131 (37%) individuals compared to 165 (46%) individuals by the analysis of Fev1/SVC ratio. In the obstruction and mixed groups, the difference in vital capacity SVC – FVC is statistically superior (p&lt;0.05) when compared to normal and restriction groups.Conclusions: The FEV1/SVC ratio detected the presence of airway obstruction in more individuals than did FEV1/FVC ratio and hence FEV1/SVC considered as more reliable factor in the detection of obstructive airway diseases.
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48

Martinez, Larissa, Diego Rodrigues, Leila Donária, et al. "Difference Between Slow and Forced Vital Capacity and Its Relationship with Dynamic Hyperinflation in Patients with Chronic Obstructive Pulmonary Disease." Lung 197, no. 1 (2018): 9–13. http://dx.doi.org/10.1007/s00408-018-0174-y.

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49

Mirzoev, Timur M., Kristina A. Sharlo та Boris S. Shenkman. "The Role of GSK-3β in the Regulation of Protein Turnover, Myosin Phenotype, and Oxidative Capacity in Skeletal Muscle under Disuse Conditions". International Journal of Molecular Sciences 22, № 10 (2021): 5081. http://dx.doi.org/10.3390/ijms22105081.

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Skeletal muscles, being one of the most abundant tissues in the body, are involved in many vital processes, such as locomotion, posture maintenance, respiration, glucose homeostasis, etc. Hence, the maintenance of skeletal muscle mass is crucial for overall health, prevention of various diseases, and contributes to an individual’s quality of life. Prolonged muscle inactivity/disuse (due to limb immobilization, mechanical ventilation, bedrest, spaceflight) represents one of the typical causes, leading to the loss of muscle mass and function. This disuse-induced muscle loss primarily results from repressed protein synthesis and increased proteolysis. Further, prolonged disuse results in slow-to-fast fiber-type transition, mitochondrial dysfunction and reduced oxidative capacity. Glycogen synthase kinase 3β (GSK-3β) is a key enzyme standing at the crossroads of various signaling pathways regulating a wide range of cellular processes. This review discusses various important roles of GSK-3β in the regulation of protein turnover, myosin phenotype, and oxidative capacity in skeletal muscles under disuse/unloading conditions and subsequent recovery. According to its vital functions, GSK-3β may represent a perspective therapeutic target in the treatment of muscle wasting induced by chronic disuse, aging, and a number of diseases.
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Koç, Murat, and Nazmi Saritaş. "The Effect of Respiratory Muscle Training on Aerobic and Anaerobic Strength in Adolescent Taekwondo Athletes." Journal of Education and Training Studies 7, no. 2 (2019): 103. http://dx.doi.org/10.11114/jets.v7i2.3764.

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This study was conducted to investigate the effect of respiratory muscle training on respiratory functions and aerobic and anaerobic strength in adolescent taekwondo athletes. Between the ages of 12–17, 32 taekwondo athletes participated in the study. Participating athletes were randomly divided into two groups as ‘’experimental group’’ (n=15) and ‘’control group’’ (n=17) as to similar characteristics. The experimental group was given respiratory muscle training for 30 min with an adjustable respiratory pressure device for 3 days a week through 8 weeks period. No exercise was given to the control group with the device. A 20 meter shuttle run test was performed for aerobic capacity and a vertical jump test was performed for anaerobic strength. The inspiratory pressure was measured. After the respiratory muscle training, statistically significant difference was found in the maximum oxygen consumption capacities (MaxVO2) and anaerobic strength values (p&lt;0.05). In the measurements of respiratory function, forced vital capacity (FVC), slow vital capacity (SVC) and maximal voluntary ventilation (MVV), significant difference was found in favor of the experimental group (p&lt;0.05). In the measurements of inspiration pressure, the results of pressure, strength, flow, volume and energy values were significantly different in favor of the experimental group (p&lt;0.05). Respiratory muscle training increased the aerobic and anaerobic strength capacity of the experimental group in comparison with the control group. Some of the exercises that were used in the treatment of COPD are thought to facilitate the athletes’ respiration control.
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