Log in

Relevant bibliographies by topics / SLOX1 / Journal articles

To see the other types of publications on this topic, follow the link: SLOX1.

Journal articles on the topic 'SLOX1'

Author: Grafiati

Published: 1 April 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'SLOX1.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Zhou, Yu, Qiong-Yao Tang, Xiao-Ming Xia, and Christopher J. Lingle. "Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix." Journal of General Physiology 135, no. 5 (2010): 481–94. http://dx.doi.org/10.1085/jgp.201010403.

Full text

Abstract:

The tremorogenic fungal metabolite, paxilline, is widely used as a potent and relatively specific blocker of Ca2+- and voltage-activated Slo1 (or BK) K+ channels. The pH-regulated Slo3 K+ channel, a Slo1 homologue, is resistant to blockade by paxilline. Taking advantage of the marked differences in paxilline sensitivity and the homology between subunits, we have examined the paxilline sensitivity of a set of chimeric Slo1/Slo3 subunits. Paxilline sensitivity is associated with elements of the S5–P loop–S6 module of the Slo1 channel. Replacement of the Slo1 S5 segment or the second half of the

APA, Harvard, Vancouver, ISO, and other styles

2

Tian, Yutao, Florian Ullrich, Rong Xu, Stefan H. Heinemann, Shangwei Hou, and Toshinori Hoshi. "Two distinct effects of PIP2 underlie auxiliary subunit-dependent modulation of Slo1 BK channels." Journal of General Physiology 145, no. 4 (2015): 331–43. http://dx.doi.org/10.1085/jgp.201511363.

Full text

Abstract:

Phosphatidylinositol 4,5-bisphosphate (PIP2) plays a critical role in modulating the function of numerous ion channels, including large-conductance Ca2+- and voltage-dependent K+ (BK, Slo1) channels. Slo1 BK channel complexes include four pore-forming Slo1 (α) subunits as well as various regulatory auxiliary subunits (β and γ) that are expressed in different tissues. We examined the molecular and biophysical mechanisms underlying the effects of brain-derived PIP2 on human Slo1 BK channel complexes with different subunit compositions that were heterologously expressed in human embryonic kidney

APA, Harvard, Vancouver, ISO, and other styles

3

Yang, Xiaoli, Duanlu Hou, Jianjun Liu, et al. "Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Level is Related to Clinical Prognosis In Patients with Acute Atherosclerosis-related Ischemic Stroke." Clinical and Applied Thrombosis/Hemostasis 27 (January 2021): 107602962110595. http://dx.doi.org/10.1177/10760296211059500.

Full text

Abstract:

To investigate the associations between soluble Lectin-like Oxidized Low-density lipoprotein receptor-1 (sLOX-1) and clinical prognosis, especially infarct volume in patients with acute atherosclerosis-related ischemic stroke. We recruited acute ischemic stroke patients within 3 days after onset. Patients were stratified into 3 groups by sLOX-1 level. Initial stroke severity was assessed using the National Institutes of Health Stroke Scale scores, and infarct volume was measured using DWI by ITK-SNAP software. The clinical prognosis was evaluated by DWI volume, clinical response at discharge,

APA, Harvard, Vancouver, ISO, and other styles

4

Zhao, Zi-wen, Yi-wei Xu, Shu-mei Li, Jin-jian Guo, Tao Yi, and Liang-long Chen. "Higher serum lectin-like oxidized low-density lipoprotein receptor-1 in patients with stable coronary artery disease is associated with major adverse cardiovascular events: A multicentre pilot study." Biochemia medica 29, no. 1 (2018): 84–93. http://dx.doi.org/10.11613/bm.2019.010705.

Full text

Abstract:

Introduction: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is involved in the pathophysiology of atherosclerosis and acute coronary syndromes (ACS). Circulating soluble LOX-1 (sLOX-1) has been linked to the risk of coronary artery disease (CAD). Our aim was to test if baseline serum sLOX-1 was associated with major adverse cardiovascular events (MACE) in patients with stable CAD. Materials and methods: This multicentre pilot study enrolled 833 stable CAD patients. All patients were followed for two years. Serum sLOX-1 concentrations were detected by enzyme-linked immunosorbe

APA, Harvard, Vancouver, ISO, and other styles

5

Li, Huilin, Weinong Guo, Kathryn A. Yamada та Jeanne M. Nerbonne. "Selective elimination of IK,slow1 in mouse ventricular myocytes expressing a dominant negative Kv1.5α subunit". American Journal of Physiology-Heart and Circulatory Physiology 286, № 1 (2004): H319—H328. http://dx.doi.org/10.1152/ajpheart.00665.2003.

Full text

Abstract:

Although previous studies have revealed a role for the voltage-gated K+ channel α-subunit Kv1.5 ( KCNA5) in the generation of the 4-aminopyridine (4-AP)-sensitive component of delayed rectification in mouse ventricles ( IK,slow1), the phenotypic consequences of manipulating IK,slow1 expression in vivo in different (mouse) models are distinct. In these experiments, point mutations were introduced in the pore region of Kv1.5 to change the tryptophan (W) at position 461 to phenylalanine (F) to produce a nonconducting subunit, Kv1.5W461F, that is shown to function as a Kv1 subfamily-specific domin

APA, Harvard, Vancouver, ISO, and other styles

6

Zhao, Zi-wen, Yi-wei Xu, Shu-mei Li, et al. "Baseline Serum sLOX-1 Concentrations Are Associated with 2-Year Major Adverse Cardiovascular and Cerebrovascular Events in Patients after Percutaneous Coronary Intervention." Disease Markers 2019 (October 20, 2019): 1–8. http://dx.doi.org/10.1155/2019/4925767.

Full text

Abstract:

Background. Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) may be a potential biomarker of coronary artery disease (CAD) and stroke. Objective. We aimed to investigate the association and prognostic value of elevated sLOX-1 concentrations with regard to long-term major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with CAD undergoing primary percutaneous coronary intervention (PCI). Methods. A total of 1011 patients were enrolled. Serum sLOX-1 concentrations were detected by the enzyme-linked immunosorbent assay (ELISA). Patients were followed

APA, Harvard, Vancouver, ISO, and other styles

7

Hao, Fangfang, Jinliang Chen, Jinnan Wu, et al. "Expression of Serum sLOX-1 in Patients with Non-Small-Cell Lung Cancer and Its Correlation with Lipid Metabolism." Canadian Respiratory Journal 2022 (April 11, 2022): 1–9. http://dx.doi.org/10.1155/2022/6619331.

Full text

Abstract:

Objective. The aim of this study was to investigate the expression level of soluble LOX-1 (sLOX-1) in the serum of non-small-cell lung cancer (NSCLC) patients and its correlation with lipid metabolism. Methods. 99 inpatients with NSCLC and 81 healthy controls were enrolled in this study. The levels of serum sLOX-1 were compared between the two groups, and the correlation of sLOX-1 with clinicopathological characteristics, blood lipid indices, and carcinoembryonic antigen was analyzed. Results. Compared with the healthy controls, sLOX-1, low-density lipoprotein, triglyceride, and carcinoembryon

APA, Harvard, Vancouver, ISO, and other styles

8

Li, Bo, Li-hua Zhang, Xin-guo Yang, Xiong-tao Liu, and Yin-gang Ren. "Serum sLOX-1 levels are associated with the presence and severity of angiographic coronary artery disease in patients with metabolic syndrome." Clinical & Investigative Medicine 33, no. 6 (2010): 398. http://dx.doi.org/10.25011/cim.v33i6.14591.

Full text

Abstract:

Purpose: Patients with metabolic syndrome are at high-risk for development of atherosclerosis and cardiovascular events. Serum soluble lectin-like oxidized low-density lipoprotein receptor-1(sLOX-1) is associated with coronary artery disease (CAD) and metabolic disorders. We sought to assess whether serum sLOX-1 levels are correlated with the presence and severity of CAD in patients with metabolic syndrome (MetS) undergoing coronary angiography. Methods: Serum sLOX-1 levels were measured in 112 consecutive patients with MetS, undergoing coronary angiography for the evaluation of CAD. The sever

APA, Harvard, Vancouver, ISO, and other styles

9

Coulon, Stéphane, Pierre-Henri L. Gaillard, Charly Chahwan, William Hayes McDonald, John R. Yates, and Paul Russell. "Slx1-Slx4 Are Subunits of a Structure-specific Endonuclease That Maintains Ribosomal DNA in Fission Yeast." Molecular Biology of the Cell 15, no. 1 (2004): 71–80. http://dx.doi.org/10.1091/mbc.e03-08-0586.

Full text

Abstract:

In most eukaryotes, genes encoding ribosomal RNAs (rDNA) are clustered in long tandem head-to-tail repeats. Studies of Saccharomyces cerevisiae have indicated that rDNA copy number is maintained through recombination events associated with site-specific blockage of replication forks (RFs). Here, we describe two Schizosaccharomyces pombe proteins, homologs of S. cerevisiae Slx1 and Slx4, as subunits of a novel type of endonuclease that maintains rDNA copy number. The Slx1-Slx4–dependent endonuclease introduces single-strand cuts in duplex DNA on the 3′ side of junctions with single-strand DNA.

APA, Harvard, Vancouver, ISO, and other styles

10

Ali Sheikh, Md Sayed. "Plasma soluble lectin-like oxidized low-density lipoprotein receptor-1 acts as a new biomarker for NSTEMI and STEMI patients." African Health Sciences 22, no. 3 (2022): 349–58. http://dx.doi.org/10.4314/ahs.v22i3.37.

Full text

Abstract:

Objective: The diagnostic significance of plasma soluble lectin-like oxidized low-density lipoprotein receptor-1(sLOX-1) for non-ST segment elevated myocardial infarction (NSTEMI) and ST segment elevated myocardial infarction (STEMI) were explored by this study. Methods: In this study, 107 acute NSTEMI, 223 acute STEMI and 107 healthy subjects, and hypoxic (1%02) ventricular cardiomyocytes H9c2 were used. Results: The significantly up-regulated plasma sLOX-1 levels in acute NSTEMI and STEMI patients compared to healthy subjects (p<0.001). Both male and female NSTEMI and STEMI gr

APA, Harvard, Vancouver, ISO, and other styles

11

Balin, Mehmet, Ahmet Çelik, M. Ali Kobat, and Adil Baydas. "Pregnancy Followed by Delivery May Affect Circulating Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels in Women of Reproductive Age." Mediators of Inflammation 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/837375.

Full text

Abstract:

Background/Objective. It is known that menopause or lack of endogenous estrogen is a risk factor for endothelial dysfunction and CAD. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is involved inmultiple phases of vascular dysfunction.The purpose of the current study was to determine the association between soluble LOX-1 (sLOX-1) and pregnancy followed by delivery in women of reproductive age.Materials/Methods. Sixty-eight subjects with pregnancy followed by delivery (group 1) and 57 subjects with nongravidity (group 2) were included in this study. Levels of sLOX-1 were measur

APA, Harvard, Vancouver, ISO, and other styles

12

Xu, Xiang, Mingzhu Wang, Jixue Sun, et al. "Structure specific DNA recognition by the SLX1–SLX4 endonuclease complex." Nucleic Acids Research 49, no. 13 (2021): 7740–52. http://dx.doi.org/10.1093/nar/gkab542.

Full text

Abstract:

Abstract The SLX1–SLX4 structure-specific endonuclease complex is involved in processing diverse DNA damage intermediates, including resolution of Holliday junctions, collapse of stalled replication forks and removal of DNA flaps. The nuclease subunit SLX1 is inactive on its own, but become activated upon binding to SLX4 via its conserved C-terminal domain (CCD). Yet, how the SLX1–SLX4 complex recognizes specific DNA structure and chooses cleavage sites remains unknown. Here we show, through a combination of structural, biochemical and computational analyses, that the SAP domain of SLX4 is cri

APA, Harvard, Vancouver, ISO, and other styles

13

Kumar, Sandeep, Wahid Ali, Sridhar Mishra, et al. "Circulating Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 (sLOX-1): A Diagnostic Indicator across the Spectrum of Acute Coronary Syndrome." Journal of Clinical Medicine 10, no. 23 (2021): 5567. http://dx.doi.org/10.3390/jcm10235567.

Full text

Abstract:

Background: Cardiac troponin is the best marker to diagnose acute coronary syndrome (ACS). However, early diagnosis using markers for plaque instability may be of significance. Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) plays an important role in the pathogenesis of atherosclerosis plaque rupture and may be a potential biomarker of coronary artery disease (CAD), including ACS. The current study aims to evaluate sLOX-1 levels in the sera of patients with ACS as an independent marker of CAD with other established diagnostic markers and assess its level before and af

APA, Harvard, Vancouver, ISO, and other styles

14

Gaur, Vineet, Weronika Ziajko, Shivlee Nirwal, Aleksandra Szlachcic, Marta Gapińska, and Marcin Nowotny. "Recognition and processing of branched DNA substrates by Slx1–Slx4 nuclease." Nucleic Acids Research 47, no. 22 (2019): 11681–90. http://dx.doi.org/10.1093/nar/gkz842.

Full text

Abstract:

Abstract Structure-selective endonucleases cleave branched DNA substrates. Slx1 is unique among structure-selective nucleases because it can cleave all branched DNA structures at multiple sites near the branch point. The mechanism behind this broad range of activity is unknown. The present study structurally and biochemically investigated fungal Slx1 to define a new protein interface that binds the non-cleaved arm of branched DNAs. The DNA arm bound at this new site was positioned at a sharp angle relative to the arm that was modeled to interact with the active site, implying that Slx1 uses DN

APA, Harvard, Vancouver, ISO, and other styles

15

Alioua, Abderrahmane, Rong Lu, Yogesh Kumar, et al. "Slo1 Caveolin-binding Motif, a Mechanism of Caveolin-1-Slo1 Interaction Regulating Slo1 Surface Expression." Journal of Biological Chemistry 283, no. 8 (2007): 4808–17. http://dx.doi.org/10.1074/jbc.m709802200.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Stankova, Teodora R., Ginka T. Delcheva, Ana I. Maneva, and Stefka V. Vladeva. "Serum Levels of Carbamylated LDL, Nitrotyrosine and Soluble Lectin-like Oxidized Low-density Lipoprotein Receptor-1 in Poorly Controlled Type 2 Diabetes Mellitus." Folia Medica 61, no. 3 (2019): 419–25. http://dx.doi.org/10.3897/folmed.61.e39343.

Full text

Abstract:

Introduction: Carbamylated low-density lipoprotein (cLDL) has profound proatherogenic properties. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) has been identified as the primary cLDL receptor. The soluble form of LOX-1 (sLOX-1) and 3-nitrotyrosine (NT) have recently been suggested as biomarkers of vascular disease. Although type 2 diabetes mellitus (T2DM) is characterised by an increased atherosclerotic risk, the clinical data on cLDL, NT and sLOX-1 levels in T2DM are limited. Aim: To explore the possible role of cLDL, NT and sLOX-1 as potential biomarkers for disease progre

APA, Harvard, Vancouver, ISO, and other styles

17

Kim, Eun Young, Yu-Hsin Chiu, and Stuart E. Dryer. "Neph1 regulates steady-state surface expression of Slo1 Ca2+-activated K+ channels: different effects in embryonic neurons and podocytes." American Journal of Physiology-Cell Physiology 297, no. 6 (2009): C1379—C1388. http://dx.doi.org/10.1152/ajpcell.00354.2009.

Full text

Abstract:

Large-conductance Ca2+-activated K+ (BKCa) channels encoded by the Slo1 gene are often components of large multiprotein complexes in excitable and nonexcitable cells. Here we show that Slo1 proteins interact with Neph1, a member of the immunoglobulin superfamily expressed in slit diaphragm domains of podocytes and in vertebrate and invertebrate nervous systems. This interaction was established by reciprocal coimmunoprecipitation of endogenous proteins from differentiated cells of a podocyte cell line, from parasympathetic neurons of the embryonic chick ciliary ganglion, and from HEK293T cells

APA, Harvard, Vancouver, ISO, and other styles

18

Sagar, Divya, Ranjitha Gaddipati, Emily Ongstad, et al. "Soluble LOX-1: A Potential biomarker for SLE and Cardiovascular Comorbidity." Journal of Immunology 200, no. 1_Supplement (2018): 45.1. http://dx.doi.org/10.4049/jimmunol.200.supp.45.1.

Full text

Abstract:

Abstract Cardiovascular disease is the leading cause of mortality among systemic lupus erythematosus (SLE) patients. LOX-1 is a scavenger receptor strongly implicated in plaque formation, progression and destabilization. It gets upregulated during vascular inflammation on endothelial cells, monocytes, macrophages, smooth muscle cells and platelets. Soluble LOX-1 (sLOX-1) can serve as a potential biomarker for identifying SLE patients with increased cardiovascular risk. In a 120 SLE patient cohort, circulating sLOX-1 levels were 2-fold higher compared to healthy controls, particularly in those1

APA, Harvard, Vancouver, ISO, and other styles

19

Pirillo, Angela, and Alberico Luigi Catapano. "Soluble Lectin-Like Oxidized Low Density Lipoprotein Receptor-1 as a Biochemical Marker for Atherosclerosis-Related Diseases." Disease Markers 35 (2013): 413–18. http://dx.doi.org/10.1155/2013/716325.

Full text

Abstract:

Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1), the main oxidized low-density lipoprotein (OxLDL) in endothelial cells, is upregulated in atherosclerotic lesions and is involved in several cellular processes that regulate the pathogenesis of atherosclerosis. The LOX-1 expressed on the cell surface can be proteolytically cleaved and released in a soluble form (sLOX-1) in the circulation under pathological conditions. Serum levels of sLOX-1, in fact, are elevated at the early stages of acute coronary syndrome and are associated with coronary plaque vulnerability and with the pre

APA, Harvard, Vancouver, ISO, and other styles

20

Coulon, Stéphane, Eishi Noguchi, Chiaki Noguchi, Li-Lin Du, Toru M. Nakamura, and Paul Russell. "Rad22Rad52-dependent Repair of Ribosomal DNA Repeats Cleaved by Slx1-Slx4 Endonuclease." Molecular Biology of the Cell 17, no. 4 (2006): 2081–90. http://dx.doi.org/10.1091/mbc.e05-11-1006.

Full text

Abstract:

Slx1 and Slx4 are subunits of a structure-specific DNA endonuclease that is found in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and other eukaryotic species. It is thought to initiate recombination events or process recombination structures that occur during the replication of the tandem repeats of the ribosomal DNA (rDNA) locus. Here, we present evidence that fission yeast Slx1-Slx4 initiates homologous recombination events in the rDNA repeats that are processed by a mechanism that requires Rad22 (Rad52 homologue) but not Rhp51 (Rad51 homologue). Slx1 is required to generate ∼50% of

APA, Harvard, Vancouver, ISO, and other styles

21

Stankova, Delcheva, Maneva, and Vladeva. "Serum Levels of Carbamylated LDL and Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 are Associated with Coronary Artery Disease in Patients with Metabolic Syndrome." Medicina 55, no. 8 (2019): 493. http://dx.doi.org/10.3390/medicina55080493.

Full text

Abstract:

Background and objectives: Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) has been recognized as the primary receptor for carbamylated low-density lipoproteins (cLDL) and is increasingly being viewed as a critical mediator of vascular inflammation and atherosclerosis. The aim of the current study was to evaluate the possible role of circulating cLDL and soluble LOX-1 (sLOX-1) as potential biomarkers of metabolic syndrome (MetS) as well as of coronary artery disease (CAD) among MetS patients. Materials and Methods: The serum levels of cLDL and sLOX-1 were measured by ELISA in 3

APA, Harvard, Vancouver, ISO, and other styles

22

Roberts, Tania M., Michael S. Kobor, Suzanne A. Bastin-Shanower, et al. "Slx4 Regulates DNA Damage Checkpoint-dependent Phosphorylation of the BRCT Domain Protein Rtt107/Esc4." Molecular Biology of the Cell 17, no. 1 (2006): 539–48. http://dx.doi.org/10.1091/mbc.e05-08-0785.

Full text

Abstract:

RTT107 (ESC4, YHR154W) encodes a BRCA1 C-terminal-domain protein that is important for recovery from DNA damage during S phase. Rtt107 is a substrate of the checkpoint protein kinase Mec1, although the mechanism by which Rtt107 is targeted by Mec1 after checkpoint activation is currently unclear. Slx4, a component of the Slx1-Slx4 structure-specific nuclease, formed a complex with Rtt107. Deletion of SLX4 conferred many of the same DNA-repair defects observed in rtt107Δ, including DNA damage sensitivity, prolonged DNA damage checkpoint activation, and increased spontaneous DNA damage. These ph

APA, Harvard, Vancouver, ISO, and other styles

23

Kim, Eun Young, Kyoung-Jae Choi, and Stuart E. Dryer. "Nephrin binds to the COOH terminus of a large-conductance Ca2+-activated K+ channel isoform and regulates its expression on the cell surface." American Journal of Physiology-Renal Physiology 295, no. 1 (2008): F235—F246. http://dx.doi.org/10.1152/ajprenal.00140.2008.

Full text

Abstract:

We carried out a yeast two-hybrid screen to identify proteins that interact with large-conductance Ca2+-activated K+ (BKCa) channels encoded by the Slo1 gene. Nephrin, an essential adhesion and scaffolding molecule expressed in podocytes, emerged in this screen. The Slo1-nephrin interaction was confirmed by coimmunoprecipitation from the brain and kidney, from HEK-293T cells expressing both proteins, and by glutathione S-transferase pull-down assays. We detected nephrin binding to the Slo1VEDEC splice variant, which is typically retained in intracellular stores, and to the β4-subunit. However,

APA, Harvard, Vancouver, ISO, and other styles

24

Ridgway, Lon D., Eun Young Kim, and Stuart E. Dryer. "MAGI-1 interacts with Slo1 channel proteins and suppresses Slo1 expression on the cell surface." American Journal of Physiology-Cell Physiology 297, no. 1 (2009): C55—C65. http://dx.doi.org/10.1152/ajpcell.00073.2009.

Full text

Abstract:

Large conductance Ca2+-activated K+ (BKCa) channels encoded by the Slo1 gene (also known as KCNMA1) are physiologically important in a wide range of cell types and form complexes with a number of other proteins that affect their function. We performed a yeast two-hybrid screen to identify proteins that interact with BKCa channels using a bait construct derived from domains in the extreme COOH-terminus of Slo1. A protein known as membrane-associated guanylate kinase with inverted orientation protein-1 (MAGI-1) was identified in this screen. MAGI-1 is a scaffolding protein that allows formation

APA, Harvard, Vancouver, ISO, and other styles

25

Ren, Kaixuan, Huayun Jiang, Tiantian Li, Chengqun Qian, Li Zhu, and Tianle Wang. "Correlation of sLOX-1 Levels and MR Characteristics of Culprit Plaques in Intracranial Arteries with Stroke Recurrence." Diagnostics 13, no. 4 (2023): 804. http://dx.doi.org/10.3390/diagnostics13040804.

Full text

Abstract:

(1) Background: Symptomatic intracranial artery atherosclerosis (sICAS) is an important cause of acute ischaemic stroke (AIS) and is associated with a high risk of stroke recurrence. High-resolution magnetic resonance vessel wall imaging (HR-MR-VWI) is an effective method for evaluating atherosclerotic plaque characteristics. Soluble lectin-like oxidised low-density lipoprotein receptor-1 (sLOX-1) is closely associated with plaque formation and rupture. We aim to explore the correlation between sLOX-1 levels and culprit plaque characteristics, based on HR-MR-VWI, with stroke recurrence in pati

APA, Harvard, Vancouver, ISO, and other styles

26

Qian, Xiang, Crina M. Nimigean, Xiaowei Niu, Brenda L. Moss та Karl L. Magleby. "Slo1 Tail Domains, but Not the Ca2+ Bowl, Are Required for the β1 Subunit to Increase the Apparent Ca2+ Sensitivity of BK Channels". Journal of General Physiology 120, № 6 (2002): 829–43. http://dx.doi.org/10.1085/jgp.20028692.

Full text

Abstract:

Functional large-conductance Ca2+- and voltage-activated K+ (BK) channels can be assembled from four α subunits (Slo1) alone, or together with four auxiliary β1 subunits to greatly increase the apparent Ca2+ sensitivity of the channel. We examined the structural features involved in this modulation with two types of experiments. In the first, the tail domain of the α subunit, which includes the RCK2 (regulator of K+ conductance) domain and Ca2+ bowl, was replaced with the tail domain of Slo3, a BK-related channel that lacks both a Ca2+ bowl and high affinity Ca2+ sensitivity. In the second, th

APA, Harvard, Vancouver, ISO, and other styles

27

Hou, Shangwei, Rong Xu, Joseph F. Clark, William L. Wurster, Stefan H. Heinemann, and Toshinori Hoshi. "Bilirubin Oxidation End Products Directly Alter K+ Channels Important in the Regulation of Vascular Tone." Journal of Cerebral Blood Flow & Metabolism 31, no. 1 (2010): 102–12. http://dx.doi.org/10.1038/jcbfm.2010.54.

Full text

Abstract:

The exact etiology of delayed cerebral vasospasm following cerebral hemorrhage is not clear, but a family of compounds termed ‘bilirubin oxidation end products (BOXes)’ derived from heme has been implicated. As proper regulation of vascular smooth muscle tone involves large-conductance Ca2+- and voltage-dependent Slo1 K+ (BK, maxiK, KCa1.1) channels, we examined whether BOXes altered functional properties of the channel. Electrophysiological measurements of Slo1 channels heterologously expressed in a human cell line and of native mouse BK channels in isolated cerebral myocytes showed that BOXe

APA, Harvard, Vancouver, ISO, and other styles

28

Hoshi, Toshinori, Rong Xu, Shangwei Hou, Stefan H. Heinemann, and Yutao Tian. "A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid." Journal of General Physiology 142, no. 5 (2013): 507–22. http://dx.doi.org/10.1085/jgp.201311061.

Full text

Abstract:

Long-chain polyunsaturated omega-3 fatty acids such as docosahexaenoic acid (DHA) at nanomolar concentrations reversibly activate human large-conductance Ca2+- and voltage-gated K+ (Slo1 BK) channels containing auxiliary β1 or β4 subunits in cell-free patches. Here we examined the action of DHA on the Slo1 channel without any auxiliary subunit and sought to elucidate the biophysical mechanism and the molecular determinants of the DHA sensitivity. Measurements of ionic currents through human Slo1 (hSlo1) channels reveal that the stimulatory effect of DHA does not require activation of the volta

APA, Harvard, Vancouver, ISO, and other styles

29

Uransilp, Nattaphol, Pannawat Chaiyawatthanananthn, and Sombat Muengtaweepongsa. "Efficacy of High-Dose and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcomes in Patient with Acute Ischemic Stroke: A Randomized, Double-Blind, Parallel, Controlled Trial." Neurology Research International 2018 (2018): 1–6. http://dx.doi.org/10.1155/2018/7268924.

Full text

Abstract:

Backgrounds. Stroke is the leading cause of death and long-term disability. Oxidative stress is elevated during occurrence of acute ischemic stroke (AIS). Soluble LOX-1 (sLOX-1) and NO are used as biomarkers for vascular oxidative stress that can reflect stabilization of atherosclerotic plaque. Previous study showed that simvastatin can reduce oxidative stress and LOX-1 expression. Objectives. To evaluate neurological outcomes and serum sLOX-1 and NO levels in patients with AIS treatment with low dose 10 mg/day and high dose 40 mg/day of simvastatin. Methods. 65 patients with AIS within 24 hou

APA, Harvard, Vancouver, ISO, and other styles

30

Zhang, Xue, Xuhui Zeng, and Christopher J. Lingle. "Slo3 K+ Channels: Voltage and pH Dependence of Macroscopic Currents." Journal of General Physiology 128, no. 3 (2006): 317–36. http://dx.doi.org/10.1085/jgp.200609552.

Full text

Abstract:

The mouse Slo3 gene (KCNMA3) encodes a K+ channel that is regulated by changes in cytosolic pH. Like Slo1 subunits responsible for the Ca2+ and voltage-activated BK-type channel, the Slo3 α subunit contains a pore module with homology to voltage-gated K+ channels and also an extensive cytosolic C terminus thought to be responsible for ligand dependence. For the Slo3 K+ channel, increases in cytosolic pH promote channel activation, but very little is known about many fundamental properties of Slo3 currents. Here we define the dependence of macroscopic conductance on voltage and pH and, in parti

APA, Harvard, Vancouver, ISO, and other styles

31

Yeste, Marc, Marc Llavanera, Guillermo Pérez, et al. "Elucidating the Role of K+ Channels during In Vitro Capacitation of Boar Spermatozoa: Do SLO1 Channels Play a Crucial Role?" International Journal of Molecular Sciences 20, no. 24 (2019): 6330. http://dx.doi.org/10.3390/ijms20246330.

Full text

Abstract:

This study sought to identify and localize SLO1 channels in boar spermatozoa by immunoblotting and immunofluorescence, and to determine their physiological role during in vitro sperm capacitation. Sperm samples from 14 boars were incubated in a capacitation medium for 300 min in the presence of paxilline (PAX), a specific SLO1-channel blocker, added either at 0 min or after 240 min of incubation. Negative controls were incubated in capacitation medium, and positive controls in capacitation medium plus tetraethyl ammonium (TEA), a general K+-channel blocker, also added at 0 min or after 240 min

APA, Harvard, Vancouver, ISO, and other styles

32

Flott, Sonja, and John Rouse. "Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage." Biochemical Journal 391, no. 2 (2005): 325–33. http://dx.doi.org/10.1042/bj20050768.

Full text

Abstract:

Members of the RecQ family of DNA helicases, mutated in several syndromes associated with cancer predisposition, are key regulators of genome stability. The Saccharomyces cerevisiae SLX4 gene is required for cell viability in the absence of Sgs1, the only yeast RecQ helicase. SLX4 encodes one subunit of the heterodimeric Slx1–Slx4 endonuclease, although its cellular function is not clear. Slx1–Slx4 was reported to preferentially cleave replication fork-like structures in vitro, and cells lacking SLX4 are hypersensitive to DNA alkylation damage. Here we report that Slx4 becomes phosphorylated i

APA, Harvard, Vancouver, ISO, and other styles

33

Zheng, Yangmin, Yuyou Huang, Lingzhi Li, et al. "sLOX-1: A Molecule for Evaluating the Prognosis of Recurrent Ischemic Stroke." Neural Plasticity 2021 (August 28, 2021): 1–9. http://dx.doi.org/10.1155/2021/6718184.

Full text

Abstract:

Several clinical parameters and biomarkers have been proposed as prognostic markers for stroke. However, it has not been clarified whether the risk factors affecting the prognosis of patients with recurrent and first-ever stroke are similar. In this study, we aimed to explore the relationship between soluble lectin-like oxidized low-density lipoprotein receptor 1 (sLOX-1) levels and the prediction of the functional outcome in patients with recurrent and first-ever stroke. A total of 266 patients with recurrent and first-ever stroke, who underwent follow-up for 3 months, were included in this s

APA, Harvard, Vancouver, ISO, and other styles

34

Horrigan, Frank T., Stefan H. Heinemann, and Toshinori Hoshi. "Heme Regulates Allosteric Activation of the Slo1 BK Channel." Journal of General Physiology 126, no. 1 (2005): 7–21. http://dx.doi.org/10.1085/jgp.200509262.

Full text

Abstract:

Large conductance calcium-dependent (Slo1 BK) channels are allosterically activated by membrane depolarization and divalent cations, and possess a rich modulatory repertoire. Recently, intracellular heme has been identified as a potent regulator of Slo1 BK channels (Tang, X.D., R. Xu, M.F. Reynolds, M.L. Garcia, S.H. Heinemann, and T. Hoshi. 2003. Nature. 425:531–535). Here we investigated the mechanism of the regulatory action of heme on heterologously expressed Slo1 BK channels by separating the influences of voltage and divalent cations. In the absence of divalent cations, heme generally de

APA, Harvard, Vancouver, ISO, and other styles

35

Zhou, Yu, Huanghe Yang, Jianmin Cui, and Christopher J. Lingle. "Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel." Journal of General Physiology 149, no. 11 (2017): 985–1007. http://dx.doi.org/10.1085/jgp.201711845.

Full text

Abstract:

For those interested in the machinery of ion channel gating, the Ca2+ and voltage-activated BK K+ channel provides a compelling topic for investigation, by virtue of its dual allosteric regulation by both voltage and intracellular Ca2+ and because its large-single channel conductance facilitates detailed kinetic analysis. Over the years, biophysical analyses have illuminated details of the allosteric regulation of BK channels and revealed insights into the mechanism of BK gating, e.g., inner cavity size and accessibility and voltage sensor-pore coupling. Now the publication of two structures o

APA, Harvard, Vancouver, ISO, and other styles

36

Çoner, Ali, Alp Aydınalp, and Haldun Müderrisoğlu. "Evaluation of hs-CRP and sLOX-1 Levels in Moderate-to-High Risk Acute Coronary Syndromes." Endocrine, Metabolic & Immune Disorders - Drug Targets 20, no. 1 (2020): 96–103. http://dx.doi.org/10.2174/1871530319666190408145905.

Full text

Abstract:

Objective: Risk stratification and prompt treatment are essential for the management of acute coronary syndromes (ACS) and prediction of future prognosis. Subclinical vascular inflammation and novel biomarkers play an important role in the clinical evaluation of ACS patients. Methods: We enrolled patients who were admitted to emergency service with unstable angina or non- ST segment elevated ACS (NSTE-ACS) in the study population. Coronary artery disease (CAD) complexity was determined via evaluation of angiographical views and peripheral venous blood samples were collected to measure highly s

APA, Harvard, Vancouver, ISO, and other styles

37

Zhou, Xiaohong, Maria DeLucia, and Jinwoo Ahn. "SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 Protein by HIV-1 Viral Protein R (Vpr)." Journal of Biological Chemistry 291, no. 33 (2016): 16936–47. http://dx.doi.org/10.1074/jbc.m116.721183.

Full text

Abstract:

Evolutionarily conserved structure-selective endonuclease MUS81 forms a complex with EME1 and further associates with another endonuclease SLX4-SLX1 to form a four-subunit complex of MUS81-EME1-SLX4-SLX1, coordinating distinctive biochemical activities of both endonucleases in DNA repair. Viral protein R (Vpr), a highly conserved accessory protein in primate lentiviruses, was previously reported to bind SLX4 to mediate down-regulation of MUS81. However, the detailed mechanism underlying MUS81 down-regulation is unclear. Here, we report that HIV-1 Vpr down-regulates both MUS81 and its cofactor

APA, Harvard, Vancouver, ISO, and other styles

38

Chen, Mingyi, Xin Lin, Hannah Archibald, Ted Wun, and Ralph Green. "Increased Circulating Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor (sLOX-1) and Increased Endothelial Cell Expression of LOX-1 in Sickle Cell Disease (SCD): A Novel Marker for SCD Vasculopathy?" Blood 120, no. 21 (2012): 246. http://dx.doi.org/10.1182/blood.v120.21.246.246.

Full text

Abstract:

Abstract Abstract 246 Introduction: Inflammation and abnormal adhesion of sickle red blood cells (RBCs), leukocytes and platelets to the vascular endothelium are postulated to play a central role in the pathogenesis of vaculopathy associated with sickle cell disease (SCD). Dysfunctional endothelial cells in the SCD vaso-occlusive process display vasoconstriction, proinflammatory and prothrombotic changes. Sickle RBCs may damage or activate the endothelium via enhanced expression of cell surface adhesion molecules such as vascular cell adhesion molecule (VCAM), intercellular adhesion molecules

APA, Harvard, Vancouver, ISO, and other styles

39

Magleby, Karl L. "Gating Mechanism of BK (Slo1) Channels." Journal of General Physiology 121, no. 2 (2003): 81–96. http://dx.doi.org/10.1085/jgp.20028721.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Tian, Yutao, Stefan H. Heinemann, and Toshinori Hoshi. "Large-conductance Ca2+- and voltage-gated K+channels form and break interactions with membrane lipids during each gating cycle." Proceedings of the National Academy of Sciences 116, no. 17 (2019): 8591–96. http://dx.doi.org/10.1073/pnas.1901381116.

Full text

Abstract:

Membrane depolarization and intracellular Ca2+promote activation of the large-conductance Ca2+- and voltage-gated (Slo1) big potassium (BK) channel. We examined the physical interactions that stabilize the closed and open conformations of the ion conduction gate of the human Slo1 channel using electrophysiological and computational approaches. The results show that the closed conformation is stabilized by intersubunit ion–ion interactions involving negative residues (E321 and E324) and positive residues (329RKK331) at the cytoplasmic ends of the transmembrane S6 segments (“RKK ring”). When the

APA, Harvard, Vancouver, ISO, and other styles

41

Kim, Yonghwan, Gabriella S. Spitz, Uma Veturi, Francis P. Lach, Arleen D. Auerbach, and Agata Smogorzewska. "Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4." Blood 121, no. 1 (2013): 54–63. http://dx.doi.org/10.1182/blood-2012-07-441212.

Full text

Abstract:

Abstract SLX4, the newly identified Fanconi anemia protein, FANCP, is implicated in repairing DNA damage induced by DNA interstrand cross-linking (ICL) agents, topoisomerase I (TOP1) inhibitors, and in Holliday junction resolution. It interacts with and enhances the activity of XPF-ERCC1, MUS81-EME1, and SLX1 nucleases, but the requirement for the specific nucleases in SLX4 function is unclear. Here, by complementing a null FA-P Fanconi anemia cell line with SLX4 mutants that specifically lack the interaction with each of the nucleases, we show that the SLX4-dependent XPF-ERCC1 activity is ess

APA, Harvard, Vancouver, ISO, and other styles

42

Mullen, Janet R., Vivek Kaliraman, Samer S. Ibrahim, and Steven J. Brill. "Requirement for Three Novel Protein Complexes in the Absence of the Sgs1 DNA Helicase in Saccharomyces cerevisiae." Genetics 157, no. 1 (2001): 103–18. http://dx.doi.org/10.1093/genetics/157.1.103.

Full text

Abstract:

Abstract The Saccharomyces cerevisiae Sgs1 protein is a member of the RecQ family of DNA helicases and is required for genome stability, but not cell viability. To identify proteins that function in the absence of Sgs1, a synthetic-lethal screen was performed. We obtained mutations in six complementation groups that we refer to as SLX genes. Most of the SLX genes encode uncharacterized open reading frames that are conserved in other species. None of these genes is required for viability and all SLX null mutations are synthetically lethal with mutations in TOP3, encoding the SGS1-interacting DN

APA, Harvard, Vancouver, ISO, and other styles

43

Rouse, John. "Control of genome stability by Slx protein complexes." Biochemical Society Transactions 37, no. 3 (2009): 495–510. http://dx.doi.org/10.1042/bst0370495.

Full text

Abstract:

The six Saccharomyces cerevisiae SLX genes were identified in a screen for factors required for the viability of cells lacking Sgs1, a member of the RecQ helicase family involved in processing stalled replisomes and in the maintenance of genome stability. The six SLX gene products form three distinct heterodimeric complexes, and all three have catalytic activity. Slx3–Slx2 (also known as Mus81–Mms4) and Slx1–Slx4 are both heterodimeric endonucleases with a marked specificity for branched replication fork-like DNA species, whereas Slx5–Slx8 is a SUMO (small ubiquitin-related modifier)-targeted

APA, Harvard, Vancouver, ISO, and other styles

44

Inoue, Nobutaka, Tomonori Okamura, Yoshihiro Kokubo, et al. "LOX Index, a Novel Predictive Biochemical Marker for Coronary Heart Disease and Stroke." Clinical Chemistry 56, no. 4 (2010): 550–58. http://dx.doi.org/10.1373/clinchem.2009.140707.

Full text

Abstract:

Abstract Background: Lectin-like oxidized LDL receptor 1 (LOX-1) is implicated in atherothrombotic diseases. Activation of LOX-1 in humans can be evaluated by use of the LOX index, obtained by multiplying the circulating concentration of LOX-1 ligands containing apolipoprotein B (LAB) times that of the soluble form of LOX-1 (sLOX-1) [LOX index = LAB × sLOX-1]. This study aimed to establish the prognostic value of the LOX index for coronary heart disease (CHD) and stroke in a community-based cohort. Methods: An 11-year cohort study of 2437 residents age 30–79 years was performed in an urban are

APA, Harvard, Vancouver, ISO, and other styles

45

Cochet-Escartin, Olivier, Jason A. Carter, Milena Chakraverti-Wuerthwein, Joydeb Sinha, and Eva-Maria S. Collins. "Slo1 regulates ethanol-induced scrunching in freshwater planarians." Physical Biology 13, no. 5 (2016): 055001. http://dx.doi.org/10.1088/1478-3975/13/5/055001.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Liu, Jianxi, Anna N. Bukiya, Guruprasad Kuntamallappanavar, Aditya K. Singh, and Alex M. Dopico. "Distinct Sensitivity of Slo1 Channel Proteins to Ethanol." Molecular Pharmacology 83, no. 1 (2012): 235–44. http://dx.doi.org/10.1124/mol.112.081240.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Ando, Makoto, Takayuki Matsumoto, Shota Kobayashi, Maika Iguchi, Kumiko Taguchi, and Tsuneo Kobayashi. "Differential participation of calcium-activated potassium channel in endothelium-dependent hyperpolarization-type relaxation in superior mesenteric arteries of spontaneously hypertensive rats." Canadian Journal of Physiology and Pharmacology 96, no. 8 (2018): 839–44. http://dx.doi.org/10.1139/cjpp-2017-0557.

Full text

Abstract:

The purpose of this study was to determine the relationship of KCa channels to endothelium-dependent hyperpolarizing factor (EDHF)-mediated relaxation induced by acetylcholine (ACh) in the superior mesenteric arteries of 7-month-old spontaneously hypertensive rats (SHR). Upon inhibition of nitric oxide synthase and cyclooxygenase, ACh-induced EDHF-mediated relaxation was found to be weaker in SHR than in age-matched Wistar Kyoto rats (WKY). These relaxations in both group were attenuated by combined treatment with small-conductance and intermediate-conductance Ca2+-activated K+ channels (SKCa

APA, Harvard, Vancouver, ISO, and other styles

48

Contreras, Gustavo F., Karen Castillo, Nicolás Enrique, et al. "A BK (Slo1) channel journey from molecule to physiology." Channels 7, no. 6 (2013): 442–58. http://dx.doi.org/10.4161/chan.26242.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Zakharov, Sergey I., John P. Morrow, Guoxia Liu, Lin Yang, and Steven O. Marx. "Activation of the BK (SLO1) Potassium Channel by Mallotoxin." Journal of Biological Chemistry 280, no. 35 (2005): 30882–87. http://dx.doi.org/10.1074/jbc.m505302200.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Avdonin, Vladimir, Xiang Dong Tang, and Toshinori Hoshi. "Stimulatory Action of Internal Protons on Slo1 BK Channels." Biophysical Journal 84, no. 5 (2003): 2969–80. http://dx.doi.org/10.1016/s0006-3495(03)70023-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!