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Brettschneider, Helga. "Neues aus der Neuropädiatrie." Kinder- und Jugendmedizin 19, no. 01 (February 2019): 58–59. http://dx.doi.org/10.1055/s-0039-1682837.
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Die Neurowoche in Berlin Ende November 2018 hat sich wieder als Informationseldorado für Neuromediziner erwiesen. Ein Durchbruch wurde zum Beispiel in der Behandlung von Kleinkindern mit spinaler Muskelatrophie Typ 1 (SMA Typ 1) erzielt: Per Gentherapie lässt sich die seltene neuromuskuläre Erkrankung verlangsamen.
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Facharztmagazine, Redaktion. "2-Jahres-Daten zeigen Wirksamkeit und Verträglichkeit von Risdiplam bei SMA Typ 1." Pädiatrie 33, no. 1 (February 2021): 63. http://dx.doi.org/10.1007/s15014-021-3682-9.
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Eisenkölbl, Astrid. "Neue Therapiemöglichkeiten der spinalen Muskelatrophie." Pädiatrie & Pädologie 56, no. 2 (March 23, 2021): 59–66. http://dx.doi.org/10.1007/s00608-021-00870-0.
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ZusammenfassungSeit einiger Zeit stehen für die Behandlung der spinalen Muskelatrophie (SMA) Medikamente mit unterschiedlichen Wirkmechanismen zur Verfügung, die den Verlauf der Erkrankung erheblich beeinflussen können. Unbehandelt ist diese neuromuskuläre Erkrankung immer progredient und führt bei der schwersten Verlaufsform SMA Typ 1 meist innerhalb von 24 Monaten zum Tod. Der genetische Defekt liegt auf dem Survival-motor-neuron-1-Gen (SMN1-Gen). Dies führt zu einem Verlust von SMN1-Protein und damit zum Untergang von Motoneuronen. Bei allen Patienten liegt das SMN2-Gen, das nur etwa 10 % funktionstüchtiges Protein bilden kann, in unterschiedlicher Kopienanzahl vor und beeinflusst den klinischen Schweregrad der Erkrankung, wobei fließende Übergänge zwischen den einzelnen Typen zu beobachten sind. Das erste für die SMA zugelassene Medikament ist Spinraza®, ein Antisense-Oligonukleotid, das intrathekal verabreicht wird, das mRNA-Splicing verändert und so zu einer vermehrten Produktion von SMN2-Protein führt. Das zweite zugelassene Medikament ist Zolgensma®. Dabei handelt es sich um eine Genersatztherapie, bei der das SMN1-Gen mittels eines Virusvektors als Einmalinfusion in den Körper eingebracht wird, um dann funktionierendes SMN-Protein zu bilden. Kurz vor der Zulassung steht außerdem Risdiplam®, dies ist ein sogenanntes „small molecule“ und setzt wie Spinraza® am SMN2-Gen an. Der Vorteil besteht in der Möglichkeit der oralen Einnahme. In allen Studien zu diesen Medikamenten wurde gezeigt, dass ein möglichst früher, am besten präsymptomatischer Beginn die besten Ergebnisse in den motorischen Scores für die Patienten erbrachte. Ein Neugeborenen-Screening könnte die betroffenen Kinder noch vor Symptombeginn detektieren.
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Tanyeli, Ayhan, Metin BAŞTUĞ, Derya GÜZEL ERDOĞAN, Ali Doğan DURSUN, Fırat AKAT, and Hakan FIÇICILAR. "Deneysel Tip 1 Diabetes Mellitusta Aralıklı Hipoksinin Kardiyak Kas Kalsiyum Homeostazına Etkisi." Sakarya Medical Journal 9, no. 3 (September 16, 2019): 536–43. http://dx.doi.org/10.31832/smj.605094.
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Vaccaro, Alexandra, and J. Alex Parker. "Formes sauvages et mutées de TDP-1/TDP-43 dans la SLA." médecine/sciences 29, no. 4 (April 2013): 343–45. http://dx.doi.org/10.1051/medsci/2013294003.
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Parapat, Nicholas. "PENGARUH PENGGUNAAN MEDIA AUDIO VISUAL TERHADAP HASIL BELAJAR KELAS XII N 1 SIPAHUTAR T.P 2019/ 2020." Areopagus : Jurnal Pendidikan Dan Teologi Kristen 18, no. 1 (March 1, 2020): 67–78. http://dx.doi.org/10.46965/ja.v18i1.41.
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AbstracThis research aims to determine the influence of the use of audio visual media on the outcome of PAK grade XII students SMA Negeri 1 Sipahutar learning year 2019/2020. The research hypothesis is that there is a positive and significant influence on the use of audio visual media on the outcome of PAK grade XII students SMA Negeri 1 Sipahutar Year learning 2019/2020.This research is a correlational study using the descriptive and inferential statistical techniques. The population is the entire grade XII student of SMA Negeri 1 at the 2019/2020 Christian Protestant learning year, amounting to 358 people. Sampling using the Random Sampling technique of 12% of the population is 40 people. This research instrument is a closed poll for variable X and test for variable Y. This research is a correlational study using the descriptive and inferential statistical techniques. The population is the entire grade XII student of SMA Negeri 1 at the 2019/2020 Christian Protestant learning year, amounting to 358 people. Sampling using the Random Sampling technique of 12% of the population is 40 people. This research instrument is a closed poll for variable X and test for variable YKeywords: Penggunaan Media Audio Visual, Hasil Belajar Siswa.
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Xishan, Zhu, Yu Haojun, He Baoxin, Zhou Xinna, Jiang Ni, Zhang Hongmei, Wang Xiaoli, and Ren Jun. "Mouse Flk-1+Sca-1- Mesenchymal Stem Cells." Transplantation 97, no. 5 (March 2014): 509–17. http://dx.doi.org/10.1097/01.tp.0000442775.46133.38.
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Agusti, Ivo Selvia, and Windya Ayu Sabrina. "PENGARUH KOMPETENSI SOSIAL DAN KOMPETENSI KEPRIBADIAN GURU TERHADAP PRESTASI BELAJAR EKONOMI SISWA KELAS XI SMA NEGERI 6 MEDAN TAHUN PELAJARAN 2015/2016." NIAGAWAN 6, no. 1 (June 30, 2017): 17. http://dx.doi.org/10.24114/niaga.v6i1.7080.
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Tujuan penelitian ini untuk mengetahui pengaruh kompetensi sosial dan kompetensi guru terhadap prestasi belajar ekonomi siswa kelas VI SMA Negeri 6 Medan Tahun Ajaran 2015/2016. Hasil penelitian menunjukan bahwa: 1) terdapat tidak ada pengaruh dan tidak signifikan antara kompetensi sosial terhadap prestasi belajar ekonomi, 2) terdapat pengaruh dan signifikan antara kompetensi kepribadian guru terhadap prestasi belajar ekonomi. 3) terdapat pengaruh positif dan signifikan antara kompetensi sosial dan kompetensi kepribadian guru secara bersama-sama terhadap prestasi belajar ekonomi. Kesimpulan dari penelitian ini adalah variabel kompetensi sosial (X1) tidakberpengaruh terhadap prestasi belajar ekonomi dan variabel kompetensi kepribadian guru (X2)berpengaruh dan signifikan terhadap prestasi belajar ekonomi siswa kelas XI SMA Negeri 6 Medan T.P 2015/2016. Keywords: Kompetensi Sosial, Kompetensi Guru, Prestasi Belajar
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Anastasi, Cyril, Patricia Rousselle, Maya Talantikite, Agnès Tessier, Caroline Cluzel, Alice Bachmann, Natacha Mariano, et al. "BMP-1 disrupts cell adhesion and enhances TGF-β activation through cleavage of the matricellular protein thrombospondin-1." Science Signaling 13, no. 639 (July 7, 2020): eaba3880. http://dx.doi.org/10.1126/scisignal.aba3880.
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Bone morphogenetic protein 1 (BMP-1) is an important metalloproteinase that synchronizes growth factor activation with extracellular matrix assembly during morphogenesis and tissue repair. The mechanisms by which BMP-1 exerts these effects are highly context dependent. Because BMP-1 overexpression induces marked phenotypic changes in two human cell lines (HT1080 and 293-EBNA cells), we investigated how BMP-1 simultaneously affects cell-matrix interactions and growth factor activity in these cells. Increasing BMP-1 led to a loss of cell adhesion that depended on the matricellular glycoprotein thrombospondin-1 (TSP-1). BMP-1 cleaved TSP-1 between the VWFC/procollagen-like domain and the type 1 repeats that mediate several key TSP-1 functions. This cleavage induced the release of TSP-1 C-terminal domains from the extracellular matrix and abolished its previously described multisite cooperative interactions with heparan sulfate proteoglycans and CD36 on HT1080 cells. In addition, BMP-1–dependent proteolysis potentiated the TSP-1–mediated activation of latent transforming growth factor–β (TGF-β), leading to increased signaling through the canonical SMAD pathway. In primary human corneal stromal cells (keratocytes), endogenous BMP-1 cleaved TSP-1, and the addition of exogenous BMP-1 enhanced cleavage, but this had no substantial effect on cell adhesion. Instead, processed TSP-1 promoted the differentiation of keratocytes into myofibroblasts and stimulated production of the myofibroblast marker α-SMA, consistent with the presence of processed TSP-1 in human corneal scars. Our results indicate that BMP-1 can both trigger the disruption of cell adhesion and stimulate TGF-β signaling in TSP-1–rich microenvironments, which has important potential consequences for wound healing and tumor progression.
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Lam, Wendy, and Zhi-Qiang Zhang. "Hotspots of mite new species discovery: Parasitiformes (2013–2015)." Systematic and Applied Acarology 21, no. 10 (December 21, 2016): 1693. http://dx.doi.org/10.11158/saa.21.12.10.
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A survey of type localities of new species of the Parasitiformes described in two journals (Systematic & Applied Acarology and Zootaxa) during the last three years (2013–2015) revealed interesting patterns of species discovery. Taxonomically, the 142 new species are unevenly distributed among 24 families with the top three families accounting for over 61% of the total. The economically important Phytoseiidae is the top-ranked family. Geographically, the 142 new species of the Parasitiformes are described from 29 countries in the world. The pattern of distribution of these new species among the countries is highly uneven—over half of the new species (52.8%) are from the top 3 countries (Brazil, Iran and Turkey), whereas most countries (65.5%) have only 1–3 new species each.
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Nasution, Suci Handayani. "Peningkatan aktivitas dan hasil belajar biologi siswa melalui penerapan model pembelajaran sfae di kelas xi ipa sma ypi delitua t.p. 2015/2016." Proceeding of Biology Education 1, no. 1 (July 6, 2018): 38–49. http://dx.doi.org/10.21009/pbe.1-1.5.
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Penelitian ini bertujuan meningkatkan aktivitas dan hasil belajar biologi melalui penerapan model pembelajaran Student Facilitator and Explaining di kelas XI IPA1 SMA Yayasan Pendidikan Islam Delitua T.P. 2015/2016 pada materi sistem reproduksi. Jenis penelitian ini adalah penelitian tindakan kelas (PTK) terdiri dari tiga siklus, subjek penelitian berjumlah 20 siswa. Instrumen yang digunakan adalah tes hasil belajar pilihan berganda serta lembar observasi pengamatan aktivitas belajar siswa selama pembelajaran. Kegiatan perbaikan pembelajaran pada siklus I: pembelajaran menggunakan charta, siklus II: guru memberi kartu pertanyaan, siklus III: guru memberi kesempatan siswa bertanya dan siswa lain untuk menjawab pertanyaan yang diajukan siswa sebelumnya. Hasil penelitian menunjukkan terjadi peningkatan aktivitas belajar siswa Pada siklus I persentase aktivitas visual, mendengarkan, oral dan diskusi 62,05% (tidak tuntas), siklus II meningkat menjadi 72,26% (tidak tuntas) dan meningkat di siklus III yaitu sebesar 91,79% (tuntas). Penelitian juga menunjukkan terjadi peningkatan hasil belajar siswa secara klasikal, pada siklus I 45% (tidak tuntas), siklus II 70% (tidak tuntas), dilanjutkan ke siklus III diperoleh ketuntasan belajar klasikal 90% (tuntas). Hal ini menunjukkan penerapan model pembelajaran Student Facilitator and Explaining di kelas XI IPA SMA Yayasan Pendidikan Islam Delitua dapat meningkatkan aktivitas dan hasil belajar siswa dari siklus I sampai ke siklus III.
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Mustopa, Mustopa. "Budaya Sekolah Islami (BUSI): Studi Kasus di SMA Islam Sultan Agung 1 Semarang." Nadwa 11, no. 2 (October 17, 2017): 109. http://dx.doi.org/10.21580/nw.2017.11.2.1880.
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<p><em>The value crisis has affected the Indonesian people in all areas of life including education. </em><em>These</em><em> conditions lead to the importance of intensive value education in schools. This paper aims to find out the concept of Islamic School Culture (Busi) and its implementation pattern in SMA Islam Sultan Agung 1 Semarang. The type of this research is descriptive qualitative. The result of the research shows that Busi in Sultan Agung 1 Semarang Islamic High School includes iqra 'culture, congregational prayer culture, thaharah culture, social interaction culture, and exemplary culture. The implementation pattern </em><em>has</em><em> </em><em>been using </em><em>top down with </em><em>three step: </em><em>socialization, habituation and monitoring. This pattern has succeeded in applying these Islamic values to unite in other school cultural activities in accordance with the vision, mission and objectives of the institution.</em><strong><em></em></strong></p><p> </p><p><strong>Abstrak</strong></p><p>Krisis nilai telah menimpa bangsa Indonesia pada semua bidang kehidupan termasuk dunia pendidikan. Kondisi seperti ini menyebabkan pentingnya pendidikan nilai secara intensif di sekolah-sekolah. Tulisan ini bertujuan untuk mengetahui konsep Budaya Sekolah Islami (Busi) dan pola pelaksanaannya di SMA Islam Sultan Agung 1 Semarang. Jenis penelitian ini adalah deskriptif kualitatif. Hasil penelitian menunjukkan bahwa Busi di SMA Islam Sultan Agung 1 Semarang meliputi budaya <em>iqra</em>, budaya shalat berjamaah, budaya <em>thaharah</em>, budaya pergaulan islami, dan budaya keteladanan. Pola Pelaksanaan Busi dilaksanakan secara <em>top down</em> dengan tahapan sosialisasi, pembiasaan dan monitoring. Pola ini telah berhasil menerapkan nilai-nilai Islam tersebut menyatu dalam aktifitas budaya sekolah yang lain sesuai dengan visi, misi dan tujuan lembaga</p>
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Simanihuruk, Lambok A., and Nahor M. Simanungkalit. "PENGARUH PENGGUNAAN INTERNET SEBAGAI SUMBER BELAJAR PADA MATERI PENGINDERAAN JAUH DAN SIG TERHADAP HASIL BELAJAR TENGAH SEMESTER GEOGRAFI KELAS XII IPS SMA NEGERI 21 MEDAN T.P. 2017 / 2018." Tunas Geografi 7, no. 1 (May 17, 2019): 9. http://dx.doi.org/10.24114/tgeo.v7i1.11087.
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Penelitian ini bertujuan untuk : (1) Untuk mengetahui bagaimana penggunaan internet sebagai sumber belajar pada materi penginderaan jauh dan sistem informasi geografi di kelas XII IPS SMA Negeri 21 Medan tahun ajaran 2017/2018. (2) Untuk mengetahui bagaimana pengaruh penggunaan internet sebagai sumber belajar terhadap hasil ujian tengah semester geografi pada materi penginderaan jauh dan sistem informasi geografi kelas XII IPS di SMA Negeri 21 Medan tahun ajaran 2017/2018. Penelitian ini dilaksanakan di kelas XII IPS SMA Negeri 21 Medan Tahun Pelajaran 2017/2018. Populasi dalam penelitian ini adalah seluruh siswa kelas XII IPS SMA Negeri 21 Medan sebanyak 124 siswa. Sampel dalam penelitian ini sebanyak 40 orang. Teknik pengumpulan data dalam penelitian ini adalah studi dokumenter dan komunikasi tidak langsung. Teknik analisis data yang digunakan yaitu Analisis Regresi Linear Sederhana, Uji determinan dan Pengujian Hipotesis secara Parsial (Uji t) dengan menggunakan aplikasi SPSS IBM 20. Hasil penelitian menunjukkan bahwa : (1). Penggunaan Internet sebagai Sumber belajar di SMA Negeri 21 Medan kelas XII IPS berada pada kategori sedang sebesar 65 % dengan nilai 73- 105. (2) Pengaruh Penggunaan Internet sebagai Sumber belajar terhadap hasil belajar siswa, hal ini dibuktikan thitung sebesar 4,233. Dan apabila nilai thitung didistribusikan kepada ttabel dengan taraf signifikan 95% dan ɑ = 5% dengan dk = 40-1 = 39 maka diperoleh ttabel 2,024. Dengan demikian thitung > ttabel (4,233 > 2,024), sehingga Penggunaan Internet sebagai Sumber belajar pada materi Penginderaan Jauh dan SIG berpengaruh signifikan terhadap hasil belajar tengah semester siswa kelas XII IPS SMA Negeri 21 Medan Tahun ajaran 2017/2018.
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Susanto, Tri, Tono Sugihartono, and Dian Pujianto. "UPAYA MENINGKATKAN KEMAMPUAN SERVIS ATAS MELALUI PENERAPAN LATIHAN MENGGUNAKAN DUMBBELL PADA SISWA KELAS X IPS 6 SMA PLUS NEGERI 7 BENGKULU." KINESTETIK 3, no. 1 (March 6, 2019): 125–31. http://dx.doi.org/10.33369/jk.v3i1.8903.
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Abstrak Penelitian ini bertujuan untuk meningkatkan kemampuan servis atas dengan penerapan dumbbell pada permainan bola voli siswa kelas X IPS 6 SMA Plus Negeri 7 Bengkulu. Metode penelitian tindakan kelas dengan rancangan terdiri atas prasiklus. siklus I, dan siklus II, di mana siklus I dan siklus II dilakukan empat tahap pelaksanaan yaitu. 1) perencanaan, 2) aksi atau tindakan, 3) obserpasi, dan 4) refleksi. Subjek penelitian ini adalah adalah siswa kelas X IPS 6 SMA Plus Negeri 7 Bengkulu sebanyak 30 orang, yang terbagi menjadi 6 perempuan dan 24 laki-laki., tempat penelitian dilaksanakan di SMA Plus Negeri 7 Bengkulu. Berdasarkan hasil penelitian meningkatkan kemampuan servis atas menggunakan dumbbell. Pada prasiklus hasil tes servis atas menggunakan dumbbell memperoleh hasil nilai rata-rata ketuntasan siswa sebesar 16,66%. Pada siklus I hasil nilai rata-rata keterampilan tes kemampuan servis atas pada olahraga bola voli meningkat menjadi 50%, sedangkan hasil nilai rata-rata keterampilan tes kemampuan servis atas aktivitas guru dengan nilai 7. Pada siklua II hasil nilai rata-rata keterampilan tes kemapuan servis atas menggunakan dumbbell memperoleh hasil rata-rata 76,66% sedangakan aktifitas guru siklus ke II menjadi 10. Berdasarkan penelitian tersebut dapat disimpulkan bahwa latihan dumbbell meningkatkan kemampuan servis atas pada Siswa Kelas X Ips 6 SMA Plus Negeri 7 Bengkulu. Kata Kunci: Service Atas, Dumbbell dan Permainan Bola Voli Abstract This study aims to improve the top service capability by applying dumbbell on the students' volleyball game of class X IPS 6 SMA Plus Negeri 7 Bengkulu. The classroom action research method with the design consists of prasiklus. Cycle I, and cycle II, where cycle I and cycle II are done four stages of implementation that is. 1) planning, 2) action or action, 3) obserpation, and 4) reflection. The subjects of this research are students of class X IPS 6 SMA Plus Negeri 7 Bengkulu as many as 30 people, divided into 6 women and 24 men, where the research conducted in SMA Plus Negeri 7 Bengkulu. Based on the results of the study improve the serviceability of using dumbbell load. In prasiklus the results of top service tests using dumbbell load obtained the results of the average score of students mastery of 16.66%. In the first cycle, the average score of the skills of the top serviceability test in volleyball increased to 50%, while the average score of the skill of service ability test on teacher activity was 7. On the second score the average score of skill test Top service using dumbbell obtained an average yield of 76.66% while the activity of teachers to cycle II to 10. Based on the research it can be concluded that the dumbbell load training improves the service capability on the students of Class X Ips 6 Sma Plus Negeri 7 Bengkulu. Keywords: Top Service, Dumbbell and Game volleyball
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Malonda, Marlyn, Adrian Umboh, and Stefanus Gunawan. "Thrombospondin-1 and blood pressure in 7-8-year-old children born low birth weight and small for gestational age." Paediatrica Indonesiana 57, no. 5 (January 5, 2018): 269. http://dx.doi.org/10.14238/pi57.5.2017.1668.
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Background Thrombospondin-1 (TSP-1) is associated with endothelial damage, glomerular impairment, and hypertension. Low birth weight (LBW) and small for gestational age (SGA) children have higher risk of morbidity and mortality.Objective To assess for a possible association between TSP-1 level and blood pressure in children who were born low birth weight and small for gestational age.Methods We conducted a cross-sectional study from March to May 2015. Inclusion criteria were children who were born LBW and SGA in 2007-2008 at Prof. Dr. R. D. Kandou General Hospital, resided in Manado, North Sulawesi, had complete medical records, and whose parents consented to their participation. Exclusion criteria were children who were in puberty, obese, had renal disease, taking medications that affect blood pressure, or who were admitted to the hospital in the 2 weeks prior to enrollment. Data were analyzed using regression and simple correlation tests to assess for associations between TSP-1 and birth weight, as well as TSP-1 and blood pressure.Results Subjects’ mean TSP-1 level was 257.95 ng/dL. There was a strong negative correlation between TSP-1 and birth weight (r=-0.784; P<0.0001). In addition, there were strong positive correlations between TSP-1 level and systolic blood pressure (r=0.718; P<0.0001) as well as TSP-1 and diastolic blood pressure (r=0.670; P<0.0001).Conclusion Higher TSP-1 is associated with higher systolic and diastolic blood pressure in 7-8-year-old children who were LBW and SGA at birth. Also, TSP-1 and birth weight have a strong negative correlation.
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Malonda, Marlyn, Adrian Umboh, and Stefanus Gunawan. "Thrombospondin-1 and blood pressure in 7-8-year-old children born low birth weight and small for gestational age." Paediatrica Indonesiana 57, no. 5 (January 5, 2018): 269. http://dx.doi.org/10.14238/pi57.5.2017.269-73.
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Background Thrombospondin-1 (TSP-1) is associated with endothelial damage, glomerular impairment, and hypertension. Low birth weight (LBW) and small for gestational age (SGA) children have higher risk of morbidity and mortality.Objective To assess for a possible association between TSP-1 level and blood pressure in children who were born low birth weight and small for gestational age.Methods We conducted a cross-sectional study from March to May 2015. Inclusion criteria were children who were born LBW and SGA in 2007-2008 at Prof. Dr. R. D. Kandou General Hospital, resided in Manado, North Sulawesi, had complete medical records, and whose parents consented to their participation. Exclusion criteria were children who were in puberty, obese, had renal disease, taking medications that affect blood pressure, or who were admitted to the hospital in the 2 weeks prior to enrollment. Data were analyzed using regression and simple correlation tests to assess for associations between TSP-1 and birth weight, as well as TSP-1 and blood pressure.Results Subjects’ mean TSP-1 level was 257.95 ng/dL. There was a strong negative correlation between TSP-1 and birth weight (r=-0.784; P<0.0001). In addition, there were strong positive correlations between TSP-1 level and systolic blood pressure (r=0.718; P<0.0001) as well as TSP-1 and diastolic blood pressure (r=0.670; P<0.0001).Conclusion Higher TSP-1 is associated with higher systolic and diastolic blood pressure in 7-8-year-old children who were LBW and SGA at birth. Also, TSP-1 and birth weight have a strong negative correlation.
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Iuculano, Francesca, Carlos Maria Duarte, Núria Marbà, and Susana Agustí. "Seagrass as major source of transparent exopolymer particles in the oligotrophic Mediterranean coast." Biogeosciences 14, no. 22 (November 15, 2017): 5069–75. http://dx.doi.org/10.5194/bg-14-5069-2017.
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Abstract. The role of seagrass, Posidonia oceanica, meadows as a source of transparent exopolymer particles (TEPs) to Mediterranean coastal waters was tested by comparing the TEP dynamics in two adjacent coastal waters in the oligotrophic NW Mediterranean Sea, one characterized by oligotrophic open-sea waters and the other accumulating seagrass leaf litter, together with an experimental examination of TEP release by seagrass litter. TEP concentrations ranged from 4.6 to 90.6 µg XG (xanthan gum) Eq L−1, with mean (±SE) values of 38.7 (± 2.02) µg XG Eq L−1 in the site devoid of seagrass litter, whereas the coastal beach site accumulating leaf litter had > 10-fold mean TEP concentrations of 487.02 (± 72.8) µg XG Eq L−1. Experimental evaluation confirmed high rates of TEP production by P. oceanica litter, allowing calculations of the associated TEP yield. We demonstrated that P. oceanica is an important source of TEPs to the Mediterranean Sea, contributing an estimated 76 Gg C as TEPs annually. TEP release by P. oceanica seagrass explains the elevated TEP concentration relative to the low chlorophyll a concentration in the Mediterranean Sea.
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Woodley, J. D. "Sea-urchins exert top-down control of macroalgae on Jamaican coral reefs (1)." Coral Reefs 18, no. 2 (July 24, 1999): 192. http://dx.doi.org/10.1007/s003380050179.
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Toyota, K., J. C. McConnell, R. M. Staebler, and A. P. Dastoor. "Air-snowpack exchange of bromine, ozone and mercury in the springtime Arctic simulated by the 1-D model PHANTAS – Part 1: In-snow bromine activation and its impact on ozone." Atmospheric Chemistry and Physics Discussions 13, no. 8 (August 5, 2013): 20341–418. http://dx.doi.org/10.5194/acpd-13-20341-2013.
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Abstract. To provide a theoretical framework towards better understanding of ozone depletion events (ODEs) and atmospheric mercury depletion events (AMDEs) in the polar boundary layer, we have developed a one-dimensional model that simulates multiphase chemistry and transport of trace constituents from porous snowpack and through the atmospheric boundary layer (ABL) as a unified system. In this paper, we describe a general configuration of the model and the results of simulations related to reactive bromine release from the snowpack and ODEs during the Arctic spring. The model employs a chemical mechanism adapted from the one previously used for the simulation of multiphase halogen chemistry involving deliquesced sea-salt aerosols in the marine boundary layer. A common set of aqueous-phase reactions describe chemistry both in the liquid-like (or brine) layer on the grain surface of the snowpack and in "haze" aerosols mainly composed of sulfate in the atmosphere. The process of highly soluble/reactive trace gases, whether entering the snowpack from the atmosphere or formed via gas-phase chemistry in the snowpack interstitial air (SIA), is simulated by the uptake on brine-covered snow grains and subsequent reactions in the aqueous phase while being traveled vertically within the SIA. A "bromine explosion", by which, in a conventional definition, HOBr formed in the ambient air is deposited and then converted heterogeneously to Br2, is a dominant process of reactive bromine formation in the top 1 mm (or less) layer of the snowpack. Deeper in the snowpack, HOBr formed within the SIA leads to an in-snow bromine explosion, but a significant fraction of Br2 is also produced via aqueous radical chemistry in the brine on the surface of the snow grains. These top- and deeper-layer productions of Br2 both contribute to the Br2 release into the atmosphere, but the deeper-layer production is found to be more important for the net outflux of reactive bromine. Although ozone is removed via bromine chemistry, it is also among the key species that control both the conventional and in-snow bromine explosions. On the other hand, aqueous-phase radical chemistry initiated by photolytic OH formation in the liquid-like layer is also a significant contributor to the in-snow source of Br2 and can operate without ozone, whereas the delivery of Br2 to the atmosphere becomes much smaller after ozone is depleted. Catalytic ozone loss via bromine radicals occurs more rapidly in the SIA than in the ambient air, giving rise to apparent dry deposition velocities for ozone from the air to the snow on the order of 10−3 cm s-1 under sunlight. Overall, however, the depletion of ozone in the system is caused predominantly by ozone loss in the ambient air. Increasing depth of the turbulent ABL under windy conditions will delay the build-up of reactive bromine and the resultant loss of ozone, while leading to the higher column amount of BrO in the atmosphere. If moderately saline and acidic snowpack is as prevalent as assumed in our model runs on sea ice during the spring, the shallow, stable ABL under calm weather conditions may undergo persistent ODEs without substantial contributions from blowing/drifting snow and wind-pumping mechanisms, whereas the column densities of BrO in the ABL will likely remain too low during the course of such events to be detected unambiguously by satellite nadir measurements.
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Wagenhach, D., W. Graf, A. Minikin, U. Trefzer, J. Kipfstuhl, H. Oerter, and N. Blindow. "Reconnaissance of chemical and isotopic firn properties on top of Berkner Island, Antarctica." Annals of Glaciology 20 (1994): 307–12. http://dx.doi.org/10.3189/1994aog20-1-307-312.
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The ice cap on Berkner Island is grounded on bedrock within the Filchner-Ronne Ice Shelf and is, therefore, expected to be a well-suited place to retrieve long-term ice-core records reflecting the environmental situation of the Weddell Sea region. Shallow firn cores were drilled to 11 m at the two main summits of Berkner Island and analysed in high depth resolution for electrical d.c. conductivity(ECM), stable isotopes, chloride, sulphate, nitrate and methane-sulphonate (MSA).From the annual layering of δD and non-sea-salt (nss) sulphate, a mean annual snow accumulation of 26.6 cm water at the north dome and 17.4cm water at the south domeare obtained. As a result of ineffective wind scouring indicated by a relatively lownear-surface snow density, regular annual cycles are found for all species at least in the upper 4-5 m. Post-depositional changes are responsible for a substantial decrease o[the seasonal δD and nitrate amplitude as well as for considerable migration of the MSA signal operating below a depth of 3-4 m. The mean chemical and isotopic firn properties at the south dome correspond to the situation on the Filchner-Ronne Ice Shelf at a comparable distance to the coast, whereas the north dome is found to be much more influenced by maritime air masses. Persistent high sea-salt levels in winter snow at Berkner Island heavily obscure the determination of nss sulphate probably due to sulphate fractionation in the Antarctic sea-salt aerosol. Estimated time-scale spredict ages at 400 m depth to be ~2000 years for the north and ~3000 years for the south dome. Pleistocene ice is expected in the bottom 200 and 300 m, respectively.
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Ali, Muhammad. "PENINGKATAN AKTIVITAS DAN HASIL BELAJAR FISIKA MELALUI PEMBELAJARAN FISIKA GASING PADA SISWA KELAS X-2 SMA NEGERI 1 PINANGSORI TAHUN PELAJARAN 2016/2017." PeTeKa 1, no. 2 (June 13, 2018): 82. http://dx.doi.org/10.31604/ptk.v1i2.82-87.
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Research action class it aims to find out if a top physics learning can improve student learning outcomes and activities. The research consists of two cycles are performed in class X-2 SMA Negeri 1 Pinangsori Central Tapanuli Regency who numbered 33 students. The characteristics of this class have a liveliness and low learning outcomes than classroom X others. Indicators of success for the liveliness of the students at least 75%, and indicators of the results of the study classical at least 85% of the number of students who take the test. During the research showed an increase in the activities and achievements of student learning of the cycle I to cycle II. On cycle I nthe average ilai psychomotor students end of the cycle I of 75.85 became 79.26 end cycle II, the affective value of scientific attitude on cycle I with an average of 78.03 and rose to 80.74 on cycle II. Analysis of the cognitive learning of students obtained through exam results per cycle is done per cycle. Improvement of cognitive learning results seen from the average value obtained before students cycle 65 ketuntasan with 31%, end of cycle I average of 73.52 with ketuntasan 6 3.64 % and the end of sklus II becomes 78, 1 8 with ketuntasan 87.88 %. From the results of the research, it can be concluded that the application of learning physics top can increase the activity and results of the study physics in grade students X-2 SMA Negeri 1 Pinangsori. Keywords: activity, the results of the study and a top Physics.
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Wadman, Renske I., Marc D. Jansen, Chantall A. D. Curial, Ewout J. N. Groen, Marloes Stam, Camiel A. Wijngaarde, Jelena Medic, et al. "Analysis of FUS, PFN2, TDP-43, and PLS3 as potential disease severity modifiers in spinal muscular atrophy." Neurology Genetics 6, no. 1 (January 3, 2020): e386. http://dx.doi.org/10.1212/nxg.0000000000000386.
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ObjectiveTo investigate mutations in genes that are potential modifiers of spinal muscular atrophy (SMA) severity.MethodsWe performed a hypothesis-based search into the presence of variants in fused in sarcoma (FUS), transactive response DNA-binding protein 43 (TDP-43), plastin 3 (PLS3), and profilin 2 (PFN2) in a cohort of 153 patients with SMA types 1–4, including 19 families. Variants were detected with targeted next-generation sequencing and confirmed with Sanger sequencing. Functional effects of the identified variants were analyzed in silico and for PLS3, by analyzing expression levels in peripheral blood.ResultsWe identified 2 exonic variants in FUS exons 5 and 6 (p.R216C and p.S135N) in 2 unrelated patients, but clinical effects were not evident. We identified 8 intronic variants in PLS3 in 33 patients. Five PLS3 variants (c.1511+82T>C; c.748+130 G>A; c.367+182C>T; c.891-25T>C (rs145269469); c.1355+17A>G (rs150802596)) potentially alter exonic splice silencer or exonic splice enhancer sites. The variant c.367+182C>T, but not RNA expression levels, corresponded with a more severe phenotype in 1 family. However, this variant or level of PLS3 expression did not consistently correspond with a milder or more severe phenotype in other families or the overall cohort. We found 3 heterozygous, intronic variants in PFN2 and TDP-43 with no correlation with clinical phenotype or effects on splicing.ConclusionsPLS3 and FUS sequence variants do not modify SMA severity at the population level. Specific variants in individual patients or families do not consistently correlate with disease severity.
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Li, Tao, Hamel Tailor, Xiuzhi Li, Zujian Wang, Ying Liu, Chao He, Tao Chu, Liaodong Ai, Dongfang Pang, and Xifa Long. "Top-Seeded Solution Growth and Properties of High TC Pb(In1/2Nb1/2)O3–Pb(Zn 1/3Nb2/3O3–PbTiO3 Single Crystals." Science of Advanced Materials 5, no. 9 (September 1, 2013): 1271–74. http://dx.doi.org/10.1166/sam.2013.1582.
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Ruangvaravate, Ngamkae. "Change in Corneal Endothelial Cell Density after Baerveldt Shunt Implantation in Glaucoma Patients." Siriraj Medical Journal 73, no. 4 (March 26, 2021): 252–58. http://dx.doi.org/10.33192/smj.2021.33.
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Objective: To evaluate changes in corneal endothelial cells density (EDC) at 1 one, six, and twelve months after Baerveldt shunt implantation. Materials and Methods: This prospective study included 24 patients who underwent Baerveldt shunt implantation for refractory glaucoma, and who had one full year of post-surgical follow-up. Best corrected visual acuity (BCVA), intraocular pressure (IOP), number of glaucoma medications, central corneal thickness (CCT), corneal endothelial cell density (EDC), and morphology in central, inferior, and superotemporal (stEDC) areas were recorded at baseline, and 1, 6, and 12 months after surgery. Distance between the tip of tube to corneal endothelium (TTC) was measured using optical coherence tomography at one month after surgery. Results: Twenty-four eyes from 24 patients were analyzed. Sixty-two percent were primary open-angle glaucoma, and 73.1% of patients had previous trabeculectomy. Mean BCVA was not significantly changed. The mean IOP at six months (12.2±4.35 mmHg) and at one year (11.1±4.31 mmHg) was significantly lower than baseline (20.1±9.24 mmHg) (p<0.001 and p<0.001 respectively). Median (min, max) number of anti-glaucoma medications significantly decreased from 4 (1, 6) at baseline to 1 (0, 3) and 1 (0, 3) at six months and one year after surgery (p<0.001 and p<0.001, respectively). Mean baseline stEDC was 1,527±644 cells/mm2. From linear mixed model, stEDC showed the most significantly decreasing slope (y=1365.54 – 18.6125t, p=0.014), and CCT showed a significant increase over time (y=533.65 + 1.8853t). Pearson’s correlation coefficient between TTC and stEDC change at one year was not statistically significant (-0.403, p=0.172). Conclusion: After Baerveldt shunt implantation, EDC loss over time was found in the area closest to where the tube was placed in addition to increasing CCT. Distance from tip of tube to cornea is not the only factor that can cause EDC loss after shunt implantation. Additional study to identify other possible mechanisms is warranted.
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Gaydos, Joseph K., Leslie Dierauf, Grant Kirby, Deborah Brosnan, Kirsten Gilardi, and Gary E. Davis. "Top 10 Principles for Designing Healthy Coastal Ecosystems Like the Salish Sea." EcoHealth 5, no. 4 (December 2008): 460–71. http://dx.doi.org/10.1007/s10393-009-0209-1.
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Damanik, Dede Parsaoran. "PENGARUH MODEL QUANTUM TEACHING TERHADAP HASIL BELAJAR SISWA PADA MATERI POKOK LISTRIK DINAMIS." JURNAL PENELITIAN BIDANG PENDIDIKAN 23, no. 2 (June 21, 2018): 112. http://dx.doi.org/10.24114/jpp.v23i2.10010.
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Penelitian ini bertujuan untuk mengetahui pengaruh yang signifikan penggunaan model Quantum Teaching tehadap hasil belajar fisika pada materi pokok listrik dinamis. Jenis penelitian yang digunakan dalam penelitian ini adalah quasi eksperimen dengan desain penelitian two group pretes-postes. Populasi dalam penelitian ini adalah seluruh siswa kelas X SMA Kebangsaan Medan T.P. 2016/2017 yang terdiri dari 3 kelas dengan jumah 103 siswa. Pengambilan sampel dilakukan dengan teknik cluster random sampling, dimana siswa kelas X-1 dengan jumlah 33 siswa sebagai kelas eksperimen yang diajar dengan Model Quantum Teaching dan siswa kelas X-2 dengan jumlah 33.siswa yang diajar dengan Model pembelajaran langsung. Hasil penelitian untuk kelas eksperimen dan kelas kontrol menunjukkan bahawa data berdidstribusi normal dan homogen. Untuk uji kesamaan rata-rata pretes didapat memiliki kemampuan awal yang sama, dengan menggunakan uji t dua pihak. Kemudian diberi perlakuan untuk kelas eksperimen yang diajar dengan model Quantum teaching dan di kelas kontrol dengan model pembelajaran langsung dengan hasil nilai rata-rata postes untuk kelas eksperimen diperoleh 72 dengan standar deviasi 9,161 dan nilai rata-rata post-tes untuk kelas kontrol diperoleh 66,424 dengan standar deviasi 8,302. Dari hasil uji t satu pihak dapat disimpulkan ada pengaruh yang signifikan penggunaan model quantum teaching terhadap hasil belajar siswa pada materi pokok listrik dinamis siswa kelas X Semester II SMA Kebangsaan Medan
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Colegate, T. M., and N. Clarke. "Searching for Fast Radio Transients with SKA Phase 1." Publications of the Astronomical Society of Australia 28, no. 4 (2011): 299–316. http://dx.doi.org/10.1071/as11031.
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AbstractThe Square Kilometre Array (SKA) provides an excellent opportunity for low-cost searches for fast radio transients. The increased sensitivity and field of view of the SKA compared with other radio telescopes will make it an ideal instrument to search for impulsive emission from high–energy density events. We present a high-level search ‘use case’ and propose event rate per unit cost as a figure of merit to compare transient survey strategies for radio telescope arrays; we use event rate per beam formed and searched as a first-order approximation of this measure. Key results are that incoherent (phase-insensitive) combination of antenna signals achieves the highest event rate per beam, and that 50–100 MHz processed bandwidth is sufficient for extragalactic searches with SKA Phase 1; the gain in event rate from using the full available bandwidth is small. Greater system flexibility will enable more effective searches, but need not drive the top-level system requirements beyond those already proposed for the SKA. The most appropriate search strategy depends on the observed sky direction and the source population; for SKA Phase 1, low-frequency aperture arrays tend to be more effective for extragalactic searches, and dishes more effective for directions of increased scatter broadening, such as near the Galactic plane.
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Griewank, P. J., and D. Notz. "A 1-D modelling study of Arctic sea-ice salinity." Cryosphere 9, no. 1 (February 11, 2015): 305–29. http://dx.doi.org/10.5194/tc-9-305-2015.
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Abstract. We use a 1-D model to study how salinity evolves in Arctic sea ice. To do so, we first explore how sea-ice surface melt and flooding can be incorporated into the 1-D thermodynamic Semi-Adaptive Multi-phase Sea-Ice Model (SAMSIM) presented by Griewank and Notz (2013). We introduce flooding and a flushing parametrization which treats sea ice as a hydraulic network of horizontal and vertical fluxes. Forcing SAMSIM with 36 years of ERA-interim atmospheric reanalysis data, we obtain a modelled Arctic sea-ice salinity that agrees well with ice-core measurements. The simulations thus allow us to identify the main drivers of the observed mean salinity profile in Arctic sea ice. Our results show a 1.5–4 g kg−1 decrease of bulk salinity via gravity drainage after ice growth has ceased and before flushing sets in, which hinders approximating bulk salinity from ice thickness beyond the first growth season. In our simulations, salinity interannual variability of first-year ice is mostly restricted to the top 20 cm. We find that ice thickness, thermal resistivity, freshwater column, and stored energy change by less than 5% on average when the full salinity parametrization is replaced with a prescribed salinity profile.
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Berg and Klein. "Autoimmunhepatitis und Overlap-Syndrom: Diagnostik." Praxis 91, no. 34 (August 1, 2002): 1339–46. http://dx.doi.org/10.1024/0369-8394.91.34.1339.
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Die autoimmune Hepatitis (AIH) ist eine seltene chronische Leberkrankheit (ca. 5% aller chronischen Lebererkrankungen), bei der als Folge des Toleranzverlustes gegen hepatozelluläre Proteine eine Zerstörung der Hepatozyten mit Übergang in eine Zirrhose zugrunde liegt. Klinisch ist sie charakterisiert durch die Prädominanz des weiblichen Geschlechts, eine Hypergammaglobulinämie und das gute Ansprechen auf eine immunsuppressive Therapie. Drei verschiedene Subtypen können unterschieden werden. Die häufigste Form ist die «lupoide Hepatitis» (AIH-Typ 1) mit Nachweis der Antikörper gegen Kerne und glatte Muskulatur. Diagnostisch relevant sind in diesem Zusammenhang vor allem die Antikörper gegen Aktin. Die Anti-LKM-1-Autoantikörper sind serologisch Marker für die AIH-Typ 2. Bei jungen Menschen sind sie bevorzugt nachweisbar, und der Verlauf dieser autoimmunen Erkrankung ist aggressiver als der der lupoiden Hepatitis. Die Antikörper gegen das lösliche Leberprotein (SLA) und das Leber-Pankreas-spezifische Antigen (LP) können isoliert oder in Assoziation mit Antikörpern gegen Kerne und glatte Muskulatur auftreten. Es ist offen, ob sie eine eigene Subgruppe (AIH-Typ 3) charakterisieren. Die antineutrophilen zytoplasmatischen Antikörper (ANCA) erkennen zytoplasmatische oder nukleäre Komponenten von neutrophilen Granulozyten. Eine eindeutige Identifizierung ihrer Antigen-Determinanten steht noch aus. Sie kommen häufig bei der AIH-Typ 1, aber nicht bei der AIH-Typ 2 vor. Auch bei Patienten mit primär-sklerosierender Cholangitis (PSC) lassen sie sich häufig nachweisen (40–70%). Eine Sonderform stellt die autoimmune Cholangitis dar, die klinisch/histologisch die Kriterien einer primär-biliären Zirrhose (PBC) zeigt, serologisch jedoch negativ ist für antimitochondriale Antikörper (AMA), bei der aber hochtitrige Antikörper gegen Kerne nachweisbar sind. Man darf sie mit großer Wahrscheinlichkeit als Subtyp einer PBC klassifizieren. Finden sich klinisch/histologisch die Zeichen einer hepatitischen bzw. cholestatischen Lebererkrankung und lassen sich diese mit diagnostisch relevanten Autoantikörpern assoziieren, muss in erster Linie an ein Überlappungssyndrom gedacht werden. Mit großer Sicherheit kann z.B. die Diagnose AIH/PBC gestellt werden, wenn Antikörper gegen SLA/LP oder LKM in Assoziation mit AMA nachweisbar sind. Bei Patienten mit klassischer Manifestation einer PSC (ERCP-typische Befunde plus Colitis ulcerosa) muss dann an ein ‹Overlap› zwischen PSC und AIH gedacht werden, wenn z.B. gleichzeitig ANCA sowie die AIH-typischen Antikörper gegen SLA/LP oder LKM positiv sind. Neben diesen auf die Leber bzw. Gallengänge bezogenen autoimmunen Manifestationen kann die AIH auch mit organspezifischen Autoimmunerkrankungen insbesondere einer autoimmunen Thyreoiditis assoziiert sein. Auch bei dem polyglandulären Syndrom (APS-1), bei der multiple endokrinologische und nicht-endokrinologische Manifestationen im Vordergrund stehen, ist das Auftreten einer AIH bei einem Teil der Patienten beobachtet worden.
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Susanto, Irwan. "EFFECT OF SKILL APPROACH TO PROCESS OF STUDENT LEARNING SMA NEGERI 1 SEUNUDDON NORTH ACEH." Jurnal Pendidikan Fisika 4, no. 2 (December 1, 2015): 1. http://dx.doi.org/10.22611/jpf.v4i2.3190.
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This study aims to determine the skills approach to the learning outcomes of students in the subject matter of heat in class X at SMA Negeri 1 Seunuddon Aceh Utara. This research is a form of experiment. The population in this study were all second semester class X at SMA Negeri 1 Seunuddon Aceh Utara T.P.2013/2014 consisting of two classes of 60 people. The sample of this study is the total sample is X-1 (class experiment) is taught with the skills approach, and X-2 (control group) were taught using the conventional approach amounted to 30 0rang. Research instrument is the achievement test in the form of 20 multiple-choice questions that consists of 5 options first tested on students outside of the sample, to determine the validity, reliability, distinguishing features, and level of difficulty of the test. From the results of this study showed the average value of the experimental class pretest was 41.66 and 38.66 the control class is through testing prior knowledge obtained t <t table (1.511 <2.002) These results indicate that the ability of the two classesare the same initial. Then given a different treatment. Experimental class withthe skills approach and control classes with conventional approaches. Aftertreatment carried posttest with an average yield of 73.00 experimental class and control class 60.66. From the results of the t test obtained t> t table (4.224>1.671) with α = 0.05 df = 58, it can be concluded that there is a significant influence on the process skills approach to student learning outcomes in the subject matter of heat in class X at SMA Negeri 1 Seunuddon Aceh UtaraT.P.2013/2014.
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Griewank, P. J., and D. Notz. "A 1-D model study of Arctic sea-ice salinity." Cryosphere Discussions 8, no. 2 (March 26, 2014): 1723–93. http://dx.doi.org/10.5194/tcd-8-1723-2014.
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Abstract. We use a 1-D model to study how salinity evolves in Arctic sea ice. To do so, we first explore how sea-ice surface melt and flooding can be incorporated into the 1-D thermodynamic SAMSIM sea-ice model presented by Griewank and Notz (2013). We introduce flooding and a flushing parametrization which treats sea ice as a hydraulic network of horizontal and vertical fluxes. Forcing SAMSIM with 36 years of ERA-interim atmospheric reanalysis data, we obtain a modeled Arctic sea-ice salinity that agrees well with ice-core measurements. The simulations hence allow us to identify the main drivers of the observed mean salinity profile in Arctic sea ice. Our results show a 1.5–4 g kg−1 decrease of bulk salinity via gravity drainage after ice growth has ceased and before flushing sets in, which hinders approximating bulk salinity from ice thickness beyond the first growth season. In our simulations, salinity variability of first-year ice is mostly restricted to the top 20 cm. We find that ice thickness, thermal resistivity, freshwater column, and stored energy change by less than 5% on average when the full salinity parametrization is replaced with a prescribed salinity profile. We conclude that for earth system models the impact of fully parametrizing the Arctic temporal salinity evolution is too small to justify the increase in computational cost and model complexity.
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Faiqoh, Nurul, Nadhirotul Khasanah, Lia Puji Astuti, Riski Prayitno, and Baskoro Adi Prayitno. "Profil Keterampilan Argumentasi Siswa Kelas X dan XI MIPA di SMA Batik 1 Surakarta pada Materi Keanekaragaman Hayati." Jurnal Pendidikan Biologi 7, no. 3 (November 1, 2018): 174. http://dx.doi.org/10.24114/jpb.v7i3.10122.
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The research aims to know the argumentation skill profile and the difference of students' argumentation skill between 10th MS (Match and Science) and 11th MS in Batik 1 Senior High School of Surakarta on Biodiversity material. The type of research is descriptive quantitative using survey method. Population research is all students or 400 students of class 10th and 11th MS in SMA Batik 1 Surakarta. Sampling technique using stratified proportional random sampling. The instrument to measure the skills of the user is using essay handbooks. Analysis of argumentability was using Toulmin's Argumentation Pattern (TAP). The data were analyzed using quantitative descriptive. The results showed the quality of the students' argumentation in one of the Private High School Surakarta in sufficient category. Percentage of achievement of each indicator is 68% claim, 60% warrant, 53% data, 45% s backing and 0% rebuttal. The result of t-test got sig. (2-tailed) about 0.002. therefore we can conclude that argumentation skill of 10th and 11th MS in SMA Batik 1 Surakarta have significant differences of class X and XI argumentation skill shows a significant differences, although the argumentation skill quality of both cluster class is enough.
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Susilowati, Emi Budi, and Ahmad Ashari. "Pengembangan Sistem Evaluasi Kegiatan Belajar Mengajar Berbasis Web Studi Kasus : di SMA Negeri 1 Surakarta." IJCCS (Indonesian Journal of Computing and Cybernetics Systems) 7, no. 2 (July 31, 2013): 199. http://dx.doi.org/10.22146/ijccs.3360.
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AbstrakInternet telah menjadi sumber informasi yang tidak terbatas di dalam pendidikan. Dengan adanya internet, berbagai informasi dapat diperoleh secara mudah dan cepat serta memberikan banyak manfaat diantaranya memperluas cakrawala siswa, sebagai sumber tambahan pelajaran dan mengembangkan kreatifitas siswa. Disamping itu juga dikembangkannya online learning yang memudahkan guru dalam memberikan pengayaan materi diluar tatap muka maupun memberikan evaluasi kepada peserta didik dengan memanfaatan jaringan internet sehingga mempermudah dan memperlancar dalam penyelenggaraan pendidikan. Salah satu teknologi dalam internet yang digunakan adalah web service. Web service dibangun pada inti protokol internet yaitu TCP/IP dan HTTP. Dalam kegiatan belajar mengajar dikenal suatu evaluasi yang merupakan pengukuran hasil belajar siswa sebagai prestasi belajar, yaitu penguasaan materi pelajaran sesuai dengan kompetensi yang ditetapkan. Untuk mempermudah dalam mengukur ketercapaian belajar tersebut dikembangkan program aplikasi Sistem Evaluasi Kegiatan Belajar Mengajar Berbasis Web yang diintegrasikan dengan e-learning yang sudah tersedia, sehingga kebutuhan user yang menggunakan online test dari e-learning bisa ditangani.Penelitian ini menghasilkan web penyedia layanan analisis butir soal dan analisis ketuntasan belajar yang diintegrasikan dengan e-learning yang sudah tersedia disekolah menggunakan web service. Pengujian dilakukan dengan cara pengintegrasian data dengan e-learning dilakukan tukar menukar pesan terhadap permintaan, tanggapan dan kesalahan dalam parameter permintaan. Kata kunci— Web Service, e-learning, Analisis Evaluasi Pembelajaran AbstractThe Internet has become an unlimited source of information in education. With the Internet, information can be obtained easily and quickly and provides many benefits including expanding the horizons of students, as an additional source of learning and develop student creativity. Besides, the development of online learning that allows teachers to provide enrichment materials outside of face-to-face and provide evaluations to students with memanfaatan Internet network that simplify and streamline the education. One of the technologies used in the Internet is a web service. Web services are built on the core Internet protocols are TCP / IP and HTTP.In the teaching and learning activities that are known to an evaluation of student learning outcomes as a measurement of achievement, that mastery of the subject matter in accordance with established competencies. To make it easier to measure the achievement of learning were developed application program Evaluation System Teaching and Learning Activities are integrated with the Web-based e-learning are already available, so the user needs to use online test of the e-learning can be handled.This research resulted in the service provider's point about the analysis and the analysis of mastery learning that integrates with existing e-learning available at the school using the web service. Testing is done by integrating the data with e-learning done exchanging messages to requests, responses and errors in parameter query. Keywords—Web services, e-learning, Learning Evaluation Analysis
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Toyota, K., J. C. McConnell, R. M. Staebler, and A. P. Dastoor. "Air–snowpack exchange of bromine, ozone and mercury in the springtime Arctic simulated by the 1-D model PHANTAS – Part 1: In-snow bromine activation and its impact on ozone." Atmospheric Chemistry and Physics 14, no. 8 (April 25, 2014): 4101–33. http://dx.doi.org/10.5194/acp-14-4101-2014.
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Abstract. To provide a theoretical framework towards a better understanding of ozone depletion events (ODEs) and atmospheric mercury depletion events (AMDEs) in the polar boundary layer, we have developed a one-dimensional model that simulates multiphase chemistry and transport of trace constituents from porous snowpack and through the atmospheric boundary layer (ABL) as a unified system. This paper constitutes Part 1 of the study, describing a general configuration of the model and the results of simulations related to reactive bromine release from the snowpack and ODEs during the Arctic spring. A common set of aqueous-phase reactions describes chemistry both within the liquid-like layer (LLL) on the grain surface of the snowpack and within deliquesced "haze" aerosols mainly composed of sulfate in the atmosphere. Gas-phase reactions are also represented by the same mechanism in the atmosphere and in the snowpack interstitial air (SIA). Consequently, the model attains the capacity of simulating interactions between chemistry and mass transfer that become particularly intricate near the interface between the atmosphere and the snowpack. In the SIA, reactive uptake on LLL-coated snow grains and vertical mass transfer act simultaneously on gaseous HOBr, a fraction of which enters from the atmosphere while another fraction is formed via gas-phase chemistry in the SIA itself. A "bromine explosion", by which HOBr formed in the ambient air is deposited and then converted heterogeneously to Br2, is found to be a dominant process of reactive bromine formation in the top 1 mm layer of the snowpack. Deeper in the snowpack, HOBr formed within the SIA leads to an in-snow bromine explosion, but a significant fraction of Br2 is also produced via aqueous radical chemistry in the LLL on the surface of the snow grains. These top- and deeper-layer productions of Br2 both contribute to the release of Br2 to the atmosphere, but the deeper-layer production is found to be more important for the net outflux of reactive bromine. Although ozone is removed via bromine chemistry, it is also among the key species that control both the conventional and in-snow bromine explosions. On the other hand, aqueous-phase radical chemistry initiated by photolytic OH formation in the LLL is also a significant contributor to the in-snow source of Br2 and can operate without ozone, whereas the delivery of Br2 to the atmosphere becomes much smaller after ozone is depleted. Catalytic ozone loss via bromine radical chemistry occurs more rapidly in the SIA than in the ambient air, giving rise to apparent dry deposition velocities for ozone from the air to the snow on the order of 10−3 cm s−1 during daytime. Overall, however, the depletion of ozone in the system is caused predominantly by ozone loss in the ambient air. Increasing depth of the turbulent ABL under windy conditions will delay the buildup of reactive bromine and the resultant loss of ozone, while leading to the higher column amount of BrO in the atmosphere. During the Arctic spring, if moderately saline and acidic snowpack is as prevalent as assumed in our model runs on sea ice, the shallow, stable ABL under calm weather conditions may undergo persistent ODEs without substantial contributions from blowing/drifting snow and wind-pumping mechanisms, whereas the column densities of BrO in the ABL will likely remain too low in the course of such events to be detected unambiguously by satellite nadir measurements.
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Rahayu, Yunita, Suhendar, and Jujun Ratnasari. "Keterampilan Argumentasi Siswa Pada Materi Sistem Gerak SMA Negeri Kabupaten Sukabumi-Indonesia." BIODIK 6, no. 3 (September 5, 2020): 310–20. http://dx.doi.org/10.22437/bio.v6i3.9802.
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The study was conducted to determine the profile of the written argumentation skills of class XI students at SMA Negeri Sukabumi Regency. The method in this study uses a descriptive method with a qualitative approach. The subjects were class XI students of SMA Negeri Sukabumi with a total of 36 students, who had followed the motion system material. The instrument used was in the form of problem descriptions to measure students' argumentation skills with 10 questions that referred to the Toulmin Argumentation Pattern (TAP) argumentation skill indicators. The results showed that students' written argumentation skills were still at level 1-2, students at that level could only include claims, data, warrant and backing indicators in their answers. Whereas the refutational indicators (rebuttal) students have not been able to provide answers using refutation or reinforcement, so that the quality of student argumentation in Sukabumi District High School is still low and needs to be trained so that students' written argumentation skills can develop.
Abstrak. Penelitian dilakukan untuk mengetahui profil keterampilan argumentasi tertulis siswa kelas XI di SMA Negeri Kabupaten Sukabumi. Metode dalam penelitian ini menggunakan metode deskriptif dengan pendekatan kualitatif. Subjek penelitian adalah siswa kelas XI SMA Negeri Kabupaten Sukabumi dengan jumlah 36 siswa, yang telah mengikuti materi sistem gerak. Instrumen yang digunakan berupa soal uraian untuk mengukur keterampilan argumentasi siswa dengan jumlah 10 soal yang mengacu pada indikator keterampilan argumentasi Toulmin Argumentation Pattern (TAP). Hasil penelitian menunjukkan bahwa keterampilan argmentasi tertulis siswa masih berada di level 1-2, siswa pada level tersebut hanya bisa menyertakan indikator klaim (claim), data (data), jaminan (warrant) dan dukungan (backing) dalam jawabannya. Sedangkan pada indikator sanggahan (rebuttal) siswa belum bisa memberikan jawaban dengan menggunakan sanggahan maupun penguatan, sehingga kualitas argumentasi siswa di SMA Negeri Kabupaten Sukabumi masih rendah dan perlu untuk dilatihkan agar keterampilan argumentasi tertulis siswa dapat berkembang.
Kata kunci : Keterampilan argumentasi, sekolah menengah atas, materi sistem gerak
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Breiting, M., K. Heisch, S. Nolte-Buchholtz, M. von der Hagen, and M. Smitka. "Verwendung eines Cough-Assist zur Optimierung der Sekretelimination bei Säuglingen und Kleinkindern mit neuromuskulären Erkrankungen: Umfrage zum üblichen Vorgehen in Deutschland und Fallbericht eines Patienten mit SMA Typ 1." Zeitschrift für Palliativmedizin 13, no. 05 (September 4, 2012). http://dx.doi.org/10.1055/s-0032-1323057.
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de Torrenté, Antoine. "Typ-1-Diabetes: neue Technologie?" Swiss Medical Forum ‒ Schweizerisches Medizin-Forum 17, no. 14 (April 4, 2017). http://dx.doi.org/10.4414/smf.2017.02873.
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Donath, MY, C. Weder, A. Brunner, C. Keller, P. Zala, and B. Schwegler. "Sind Typ-1- und Typ-2-Diabetes die gleiche Krankheit?" Swiss Medical Forum ‒ Schweizerisches Medizin-Forum 9, no. 20 (May 13, 2009). http://dx.doi.org/10.4414/smf.2009.06822.
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Vetterli, Florian Kaspar, and Julia Rakusa. "Immuntherapie-induzierter Diabetes mellitus Typ 1." Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, August 29, 2018. http://dx.doi.org/10.4414/smf.2018.03332.
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Hediger, S., V. Preller, W. Jochum, B. Müllhaupt, and C. Gubler. "Glykogen-Hepatopathie bei Diabetes mellitus Typ 1." Swiss Medical Forum ‒ Schweizerisches Medizin-Forum 10, no. 30 (July 28, 2010). http://dx.doi.org/10.4414/smf.2010.07236.
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Züger, T. "Der postprandiale Blutzucker am Beispiel eines Typ-1-Diabetikers." Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, February 19, 2003. http://dx.doi.org/10.4414/smf.2003.04798.
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Schwitzgebel, Valerie, Mirjam Dirlewanger, and Philippe Klee. "Behandlung von Typ-1-Diabetes im Kindes- und Jugendalter." Swiss Medical Forum ‒ Schweizerisches Medizin-Forum 17, no. 46 (November 15, 2017). http://dx.doi.org/10.4414/smf.2017.03097.
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Gerber, Philipp A., Daniel Zimmermann, and Giatgen A. Spinas. "Diabetes mellitus Typ 1 – neue Entwicklungen in der intensivierten Insulintherapie." Swiss Medical Forum ‒ Schweizerisches Medizin-Forum 13, no. 23 (June 5, 2013). http://dx.doi.org/10.4414/smf.2013.01525.
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Die Redaktion. "Tenet - Typ-1-Diabetes - «drug eluting» - Tätowierten mit resistenten Staphylokokken - diabetische Schwangere - Assoziation?" Swiss Medical Forum ‒ Schweizerisches Medizin-Forum 6, no. 46 (November 15, 2006). http://dx.doi.org/10.4414/smf.2006.06020.
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Die Redaktion. "Stroke-Units - neue Stammzellenlinien - Prävention des Diabetes Typ 1 - Dimitri Ivanovitch Mendeleievx periodische Tabelle - Trachom - Intraartikuläre Injektionen von Kortikosteroiden." Swiss Medical Forum ‒ Schweizerisches Medizin-Forum 4, no. 37 (September 8, 2004). http://dx.doi.org/10.4414/smf.2004.05305.
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Simamora, Diana Melisa, and Pintor Simamora. "PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE GROUP INVESTIGATION TERHADAP HASIL BELAJAR PENGETAHUAN KONSEPTUAL SISWA PADA MATERI POKOK PENGUKURAN DI SMA NEGERI 1 PANCUR BATU." INPAFI (Inovasi Pembelajaran Fisika) 6, no. 2 (July 4, 2018). http://dx.doi.org/10.24114/inpafi.v6i2.10098.
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Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran kooperatif tipe group investigation (GI) terhadap pengetahuan Konseptual siswa pada materi pokok pengukuran. Jenis penelitian ini adalah quasi experiment. Populasi seluruh siswa kelas X SMA Negeri 1 Pancur Batu T.P 2017/2018 yang berjumlah 5 kelas. Pengambilan sampel pada penelitian ini menggunakan teknik cluster random sampling dan terpilih dua kelas sebagai kelas eksperimen dan kelas kontrol. Instrumen yang digunakan adalah tes pilihan berganda sebanyak 20 soal yang disertai dengan pengamatan sikap, keterampilan dan aktivitas. Data rata-rata pretes kelas eksperimen dan kelas kontrol adalah 44,861 dan 41,388. Hasil uji beda diperoleh th = 1,560 < tt = 1,994, artinya kedua kelas mempunyai kemampuan awal yang sama. Nilai rata-rata postes kelas eksperimen 75,138 dan kelas kontrol 59,305. Uji normalitas dan homogenitas menunjukkan bahwa kedua kelas berdistribusi normal dan homogen. Uji hipotesis memberikan bahwa th = 6,901 > tt = 1,667 berarti Ha diterima yang menyatakan ada perbedaan yang signifikan akibat pengaruh model pembelajaran kooperatif tipe group investigation terhadap hasil belajar pengetahuan konseptual siswa. Akhirnya disimpulkan bahwa model pembelajaran kooperatif tipe group investigation berpengaruh terhadap pengetahuan konseptual siswa pada materi pokok pengukuran di kelas X SMA Negeri 1 Pancur Batu T.P 2017/2018Kata Kunci : quasi eksperiment,group investigation, pengetahuan konseptual, konvensional
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Gaol, Leni Lumban, and Derlina . "PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE THINK PAIR SHARE (TPS) TERHADAP HASIL BELAJAR SISWA PADA MATERI POKOK LISTRIK DINAMIS KELAS X SMA NEGERI 1 TANJUNG MORAWA." INPAFI (Inovasi Pembelajaran Fisika) 4, no. 3 (August 1, 2016). http://dx.doi.org/10.24114/inpafi.v4i3.5600.
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ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh model kooperatif tipe think pair share (TPS)terhadap hasil dan aktivitas belajar siswapada materi pokoklistrik dinamis kelas X SMA Negeri 1 Tanjung Morawa T.P. 2014/2015.Penelitian ini termasuk quasi experiment. Populasipenelitian adalah seluruh siswa kelas X SMA Negeri 1 Tanjung Morawa T.P. 2014/2015 yang terdiri dari 11 kelas, dengan cara cluster random sampling terpilih kelas X-1 sebagai kelas eksperimen berjumlah 36 siswa dan kelas X-3 sebagai kelas kontrol berjumlah 36 siswa. Instrumen yang digunakan adalah tes hasil belajardan lembar observasi aktivitas siswa. Berdasarkan uji beda nilai rata-rata pretes menunjukkan bahwa kedua kelas memiliki kemampuan awal yang sama. Setelah perlakuan, diperoleh nilai rata-rata postes kelas eksperimen dengan model pembelajaran kooperatif tipe think pair share (TPS) 70,42 dan kelas kontrol dengan model pembelajaran konvensional 62,50.Hasil pengujian menunjukkan bahwa data yang diperoleh berdistribusi normal dan homogen melalui uji normalitas dan uji homogenitas data. Selanjutnya dari data observasi menunjukkan bahwa aktivitas belajar siswa dalam kelompok eksperimen termasuk dalam kategori cukup aktif. Akhirnya dapat disimpulkan bahwa secara signifikan terdapat pengaruh model pembelajaran kooperatif tipe think pair share (TPS) terhadap hasil dan aktivitas belajar siswa pada materi listrik dinamis. Kata Kunci : Quasi Experiment, Think Pair Share, Hasil Belajar
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Sihotang, Aleksander, and Sehat Simatupang. "PENGARUH MODEL PEMBELAJARANBERBASIS MASALAHMENGGUNAKANANIMASITERHADAPKEMAMPUANPEMECAHAN MASALAH FISIKA SISWAKELAS X SMA N 1 SUMBUL." INPAFI (Inovasi Pembelajaran Fisika) 4, no. 4 (November 1, 2016). http://dx.doi.org/10.24114/inpafi.v4i4.5661.
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ABSTRAK Penelitian ini bertujuan untuk mengetahui adanya pengaruh model pembelajaran berbasis masalah menggunakan animasi terhadap kemampuan pemecahan masalah fisika siswa pada materi pokok listrik dinamis kelas X semester II di SMA Negeri 1 Sumbul T.P. 2015/2016. Jenis penelitian ini adalahquasi experiment dengan populasi seluruh siswa kelas X SMA Negeri 1 Sumbul yang terdiri dari 8 kelas. Sampel penelitian diambil 2 kelas yang ditentukan dengan teknik cluster random sampling, kelas X-3 sebanyak 35 siswa sebagai kelas eksperimen yang diberi perlakuan denganmodel pembelajaranberbasis masalah menggunakan animasi dan kelas X-4 sebanyak 36 siswasebagai kelas kontrol dengan pembelajaran konvensional.Instrumen yang digunakan dalam penelitian ini adalah tes kemampuan pemecahan masalah dalam bentuk essai sebanyak 10 soal yang telah dinyatakan valid oleh ahli fisika. Uji normalitas dan uji homogenitas data pretes untuk kedua kelas sampel disimpulkan bahwa kedua kelas sampel normal dan homogen, serta kedua kelas mempunyai kemampuan awal yang sama.Hasil penelitian menunjukkan adanya pengaruh model pembelajaran berbasis masalah menggunakan animasi terhadap kemampuan pemecahan masalahfisika siswa pada materi pokok listrik dinamis kelas X SMA Negeri 1 Sumbul T.P 2015/2016. Kata kunci :pembelajaran berbasis masalah, animasi, kemampuan pemecahan masalah.
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Purba, Nur Ainun, and Khairul Amdani. "PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE GROUP INVESTIGATION TERHADAP HASIL BELAJAR SISWA PADA MATERI GERAK LURUS DI KELAS X SMAN 2 PERCUT SEI TUAN T.A. 2017/2018." INPAFI (Inovasi Pembelajaran Fisika) 6, no. 4 (February 16, 2019). http://dx.doi.org/10.24114/inpafi.v6i4.12487.
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Penelitian ini bertujuan untuk mengetahui adanya pengaruh model problem based learning terhadap hasil belajar siswa pada materi fluida statis di kelas XI semester I SMA Negeri 1 Namorambe T.P. 2017/2018. Jenis penelitian ini adalah kuasi eksperimen dengan populasi seluruh siswa kelas XI SMA Negeri 1 Namorambe yang terdiri dari 2 kelas. Sampel penelitian diambil 2 kelas yang ditentukan dengan Sampel tunggal kelas XI MIA I sebagai kelas eksperimen yang diberi perlakuan dengan menggunakan model problem based learning dan kelas XI-MIA II sebagai kelas kontrol yang menggunakan pembelajaran konvensional. Sebelum perlakuan diberikan, terlebih dahulu instrumen divalidkan oleh ahli dan oleh dua orang dosen. Instrumen yang divalidasi dalam penelitian ini adalah tes dalam bentuk essai sebanyak 10 soal. Dari hasil penelitian diperoleh, diperoleh nilai rata – rata pretes kelas eksperimen 29,26 dengan standar deviasi 6,97 dan pada kelas kontrol sebesar 26,4 dengan standar deviasi 8,41. Setelah dilakukan uji normalitas dan uji homogenitas, data nilai pretes dari kelas eksperimen dan kontrol dinyatakan berdistribusi normal dan homogen. Melalui pengujian statistik diperoleh hasil yang signifikan bahwa kemampuan awal kedua kelas adalah sama. Setelah pembelajaran selesai, diberikan postes dan diperoleh nilai rata –rata kelas eksperimen 71,5 dengan standar deviasi 9,57 dan kelas kontrol 64,83 dengan standar deviasi 9,23. Melalui pengujian statistik menggunakan uji-t satu pihak dapat disimpulkan bahwa ada pengaruh yang signifikan model Problem Based Learning terhadap hasil belajar siswa pada materi pokok fluida statis di kelas XI SMA Negeri 1 Namorambe T.P.2017/2018. Kata Kunci: model problem based learning, hasil belajar, konvensional
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Sari, Aswitha, and Betty M. Turnip Turnip. "PENGARUH MODEL PEMBELAJARAN INKUIRI TE R HADAP HASIL BELAJAR SISWA PADA MATERI POKOK GERAK LURUS DI KELAS X SMA SWASTA HARAPAN BANGSA KUALA T.P. 2014/2015." INPAFI (Inovasi Pembelajaran Fisika) 4, no. 1 (February 1, 2016). http://dx.doi.org/10.24114/inpafi.v4i1.5412.
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ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran Inkuiri terhadap hasil belajar pada materi gerak lurus di kelas X SMA Swasta Harapan Bangsa Kuala T.P. 2014/2015. Jenis penelitian ini adalah quasi eksperimen dengan populasi seluruh siswa kelas X SMA Swasta Harapan Bangsa yang terdiri dari 2 kelas. Sampel penelitian diambil 2 kelas yang ditentukan dengan teknik cluster random sampling, yaitu kelas X-1 dengan menggunakan model pembelajaran inkuiri dan kelas X-2 dengan pembelajaran konvensional. Instrumen yang digunakan dalam penelitian ini terdiri dari: (1) tes hasil belajar kognitif dalam bentuk pilihan berganda dengan 5 option sebanyak 20 soal, (2) lembar observasi afektif siswa, dan (3) lembar observasi psikomotorik siswa. Analisa data menunjukkan nilai rata-rata pretes kelas eksperimen 27,97 dan kelas kontrol 29,83. Hasil analisis data pretes menunjukkan bahwa sampel berasal dari populasi yang berdistribusi normal, varians kedua sampel homogen, dan kedua sampel memiliki kemampuan awal yang sama. Setelah dilakukan perlakuan dan sekaligus mengobservasi afektif dan psikomotorik diperoleh nilai rata-rata postes pada kelas eksperimen dan kelas kontrol masing-masing 72,50 dan 65,67. Berdasarkan hasil analisis data postes menggunakan uji-t diperoleh bahwa ada pengaruh model pembelajaran Inkuiri terhadap hasil belajar siswa pada pada materi pokok gerak lurus di kelas X SMA Swasta Harapan Bangsa Kuala T.P 2014/2015. Model pembelajaran inkuiri dapat digunakan sebagai salah satu alternatif model pembelajaran dalam upaya meningkatkan hasil belajar siswa. Kata Kunci : model pembelajaran inkuiri, hasil belajar, gerak lurus.