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Journal articles on the topic 'Small animal imaging'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Lewis, Jason S., S. Achilefu, J. R. Garbow, R. Laforest, and M. J. Welch. "Small animal imaging." European Journal of Cancer 38, no. 16 (2002): 2173–88. http://dx.doi.org/10.1016/s0959-8049(02)00394-5.

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2

Ntziachristos, Vasilis, Joseph P. Culver, Bradley W. Rice, and Special Section Guest Editors. "Small-Animal Optical Imaging." Journal of Biomedical Optics 13, no. 1 (2008): 011001. http://dx.doi.org/10.1117/1.2890838.

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3

Hutchins, G. D., M. A. Miller, V. C. Soon, and T. Receveur. "Small Animal PET Imaging." ILAR Journal 49, no. 1 (2008): 54–65. http://dx.doi.org/10.1093/ilar.49.1.54.

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4

de Kemp, R. A., F. H. Epstein, C. Catana, B. M. W. Tsui, and E. L. Ritman. "Small-Animal Molecular Imaging Methods." Journal of Nuclear Medicine 51, Supplement_1 (2010): 18S—32S. http://dx.doi.org/10.2967/jnumed.109.068148.

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5

Fine, Eugene J., Lawrence Herbst, Linda A. Jelicks, Wade Koba, and Daniel Theele. "Small-Animal Research Imaging Devices." Seminars in Nuclear Medicine 44, no. 1 (2014): 57–65. http://dx.doi.org/10.1053/j.semnuclmed.2013.08.006.

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6

Bartling, Soenke, Wolfram Stiller, Wolfhard Semmler, and Fabian Kiessling. "Small Animal Computed Tomography Imaging." Current Medical Imaging Reviews 3, no. 1 (2007): 45–59. http://dx.doi.org/10.2174/157340507779940327.

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7

PECK, GRAHAM. "Manual of Small Animal Diagnostic Imaging." Journal of Small Animal Practice 36, no. 12 (1995): 546. http://dx.doi.org/10.1111/j.1748-5827.1995.tb02808.x.

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8

Tennant, Bryn. "Small Animal Review." Companion Animal 24, no. 6 (2019): 286. http://dx.doi.org/10.12968/coan.2019.24.6.286.

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Introduction: Cats showing seizure activity at under 12 months of age are more likely to have primary (structural) epilepsy than idiopathic epilepsy or reactive seizures. Advanced diagnostic imaging is recommended for cats with juvenile-onset seizures once metabolic and toxic causes have been excluded.

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9

FUJII, Hirofumi, Izumi O. UMEDA, and Yoshiki KOJIMA. "VIII. Small Animal Imaging Using SPECT." RADIOISOTOPES 57, no. 3 (2008): 219–32. http://dx.doi.org/10.3769/radioisotopes.57.219.

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10

Pomper, M., and J. Lee. "Small Animal Imaging in Drug Development." Current Pharmaceutical Design 11, no. 25 (2005): 3247–72. http://dx.doi.org/10.2174/138161205774424681.

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11

Glaser, Vicki. "Improving In Vivo Small Animal Imaging." Genetic Engineering & Biotechnology News 33, no. 3 (2013): 1, 34–35. http://dx.doi.org/10.1089/gen.33.3.18.

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12

Croft, Barbara Y., and John M. Hoffman. "NCI-Funded Small Animal Imaging Programs." Academic Radiology 8, no. 4 (2001): 372–74. http://dx.doi.org/10.1016/s1076-6332(03)80511-1.

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13

Zhou, Jing, Zhuang Liu, and Fuyou Li. "Upconversion nanophosphors for small-animal imaging." Chem. Soc. Rev. 41, no. 3 (2012): 1323–49. http://dx.doi.org/10.1039/c1cs15187h.

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14

Kindlmann, Gordon, Richard A. Normann, Arun Badi, Charles Keller, Greg M. Jones, and Christopher R. Johnson. "Scientific visualization in small animal imaging." ACM SIGGRAPH Computer Graphics 38, no. 2 (2004): 4–7. http://dx.doi.org/10.1145/1012283.1012291.

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15

Kundu, B. K., A. V. Stolin, J. Pole, et al. "Tri-modality small animal imaging system." IEEE Transactions on Nuclear Science 53, no. 1 (2006): 66–70. http://dx.doi.org/10.1109/tns.2005.862970.

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16

Balaban, R. S., and V. A. Hampshire. "Challenges in Small Animal Noninvasive Imaging." ILAR Journal 42, no. 3 (2001): 248–62. http://dx.doi.org/10.1093/ilar.42.3.248.

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17

Jelicks, Linda A., Herbert B. Tanowitz, and Chris Albanese. "Small Animal Imaging of Human Disease." American Journal of Pathology 182, no. 2 (2013): 294–95. http://dx.doi.org/10.1016/j.ajpath.2012.11.015.

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18

Gough, Alex. "Small animal Review." Companion Animal 27, no. 3 (2022): 48. http://dx.doi.org/10.12968/coan.2022.27.3.48.

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Introduction: Computed tomography is an advanced imaging modality, giving detailed three-dimensional images with good differentiation between tissue densities, useful for orthopaedic and soft tissue imaging. The use of contrast improves its accuracy when imaging soft tissues and allows angiography. Computed tomography has become much more widely available in practice in the UK in recent years, with most referral centres and some larger primary practices now boasting their own facilities, often used by other practices when referring cases for outpatient scans. Studies regarding the use of compu

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19

Wirrwar, A., C. Antke, K. Kley, H. W. Müller, and S. Nikolaus. "State-of-the-art of small animal imaging with high-resolution SPECT." Nuklearmedizin 44, no. 06 (2005): 257–66. http://dx.doi.org/10.1055/s-0038-1625323.

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SummaryDuring the recent years, in vivo imaging of small animals using SPECT has become of growing relevance. Along with the development of dedicated high-resolution small animal SPECT cameras, an increasing number of conventional clinical scanners has been equipped with single or multipinhole collimators. This paper reviews the small animal tomographs, which are operating at present and compares their performance characteristics. Furthermore, we describe the in vivo imaging studies, which have been performed so far with the individual scanners and survey current approaches to optimize molecul

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20

Gallagher, Sean R., Meng Yang, Eric Ibsen, et al. "Abstract 6298: The first fully automated, integrated workflow between a small animal imaging tool and animal study management software improves the accuracy, reproducibility, and efficiency of small animal imaging studies." Cancer Research 85, no. 8_Supplement_1 (2025): 6298. https://doi.org/10.1158/1538-7445.am2025-6298.

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Abstract Preclinical imaging systems and electronic data capture (EDC) technologies are transforming biomedical research and drug discovery by offering powerful, time-saving tools for oncology study data acquisition, analysis, and management. Advanced imaging modalities, such as bioluminescence, fluorescence, CT, MRI, and PET imaging, allow researchers to non-invasively visualize and quantify biological processes in small animal models. These systems support longitudinal studies of disease progression, therapeutic efficacy, and molecular mechanisms, aiding novel drug development while minimizi

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21

Kye, Hyunjun, Yuon Song, Tsedendamba Ninjbadgar, Chulhong Kim, and Jeesu Kim. "Whole-Body Photoacoustic Imaging Techniques for Preclinical Small Animal Studies." Sensors 22, no. 14 (2022): 5130. http://dx.doi.org/10.3390/s22145130.

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Photoacoustic imaging is a hybrid imaging technique that has received considerable attention in biomedical studies. In contrast to pure optical imaging techniques, photoacoustic imaging enables the visualization of optical absorption properties at deeper imaging depths. In preclinical small animal studies, photoacoustic imaging is widely used to visualize biodistribution at the molecular level. Monitoring the whole-body distribution of chromophores in small animals is a key method used in preclinical research, including drug-delivery monitoring, treatment assessment, contrast-enhanced tumor im

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22

Tsui, B. M. W., and D. L. Kraitchman. "Recent Advances in Small-Animal Cardiovascular Imaging." Journal of Nuclear Medicine 50, no. 5 (2009): 667–70. http://dx.doi.org/10.2967/jnumed.108.058479.

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23

Carpenter, Colin M., Conroy Sun, Guillem Pratx, Hongguang Liu, Zhen Cheng, and Lei Xing. "Radioluminescent nanophosphors enable multiplexed small-animal imaging." Optics Express 20, no. 11 (2012): 11598. http://dx.doi.org/10.1364/oe.20.011598.

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24

Li, Changqing, Gregory S. Mitchell, and Simon R. Cherry. "Cerenkov luminescence tomography for small-animal imaging." Optics Letters 35, no. 7 (2010): 1109. http://dx.doi.org/10.1364/ol.35.001109.

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25

Michalowski, J. "Imaging Facilities Focus On Small Animal Research." JNCI Journal of the National Cancer Institute 93, no. 23 (2001): 1773–74. http://dx.doi.org/10.1093/jnci/93.23.1773.

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26

Aguiar, Pablo, Anxo Fernández-Ferreiro, Filippo Galli, and Charalampos Tsoumpas. "Imaging Biomarkers in Translational Small Animal Models." Contrast Media & Molecular Imaging 2019 (February 4, 2019): 1–2. http://dx.doi.org/10.1155/2019/9469041.

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27

Valéra, Marie-Cécile, Bernard Payrastre, and Olivier Lairez. "Nuclear imaging of thrombosis in small animal." Platelets 28, no. 7 (2016): 643–48. http://dx.doi.org/10.1080/09537104.2016.1246720.

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28

Cao, Xu, Yuzhu Gong, Yang Li, et al. "Persistent luminescence tomography for small animal imaging." Biomedical Optics Express 8, no. 3 (2017): 1466. http://dx.doi.org/10.1364/boe.8.001466.

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29

Magata, Yasuhiro. "Small animal imaging studies and their prospects." Folia Pharmacologica Japonica 147, no. 3 (2016): 161–67. http://dx.doi.org/10.1254/fpj.147.161.

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30

Breton, E., P. Choquet, C. Goetz, et al. "Dual SPECT/MR imaging in small animal." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 571, no. 1-2 (2007): 446–48. http://dx.doi.org/10.1016/j.nima.2006.10.131.

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31

Youn, Hyewon, and Kee-Jong Hong. "In vivo Noninvasive Small Animal Molecular Imaging." Osong Public Health and Research Perspectives 3, no. 1 (2012): 48–59. http://dx.doi.org/10.1016/j.phrp.2012.02.002.

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32

Driehuys, B., J. Nouls, A. Badea, et al. "Small Animal Imaging with Magnetic Resonance Microscopy." ILAR Journal 49, no. 1 (2008): 35–53. http://dx.doi.org/10.1093/ilar.49.1.35.

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33

Nuyts, Johan, Kathleen Vunckx, Michel Defrise, and Christian Vanhove. "Small animal imaging with multi-pinhole SPECT." Methods 48, no. 2 (2009): 83–91. http://dx.doi.org/10.1016/j.ymeth.2009.03.015.

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34

Bakermans, Adrianus J., Desiree Abdurrachim, Rik P. M. Moonen, et al. "Small animal cardiovascular MR imaging and spectroscopy." Progress in Nuclear Magnetic Resonance Spectroscopy 88-89 (August 2015): 1–47. http://dx.doi.org/10.1016/j.pnmrs.2015.03.001.

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35

QI, Y. "High-resolution SPECT for small-animal imaging." Nuclear Science and Techniques 17, no. 3 (2006): 164–69. http://dx.doi.org/10.1016/s1001-8042(06)60032-8.

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36

Lecomte, Roger. "Technology challenges in small animal PET imaging." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 527, no. 1-2 (2004): 157–65. http://dx.doi.org/10.1016/j.nima.2004.03.113.

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37

Rivers, Bill J., and Gary R. Johnston. "Diagnostic Imaging Strategies in Small Animal Nephrology." Veterinary Clinics of North America: Small Animal Practice 26, no. 6 (1996): 1505–17. http://dx.doi.org/10.1016/s0195-5616(96)50138-5.

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38

Binderup, Tina, Henrik H. El-Ali, Valentina Ambrosini, et al. "Molecular Imaging with Small Animal PET/CT." Current Medical Imaging Reviews 7, no. 3 (2011): 234–47. http://dx.doi.org/10.2174/157340511796411221.

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39

Khalil, Magdy. "Small Animal micro-PET imaging: an overview." Egyptian Journal Nuclear Medicine 14, no. 14 (2017): 8–27. http://dx.doi.org/10.21608/egyjnm.2017.5435.

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40

Weisenberger, A. G., R. Wojcik, E. L. Bradley, et al. "SPECT-CT system for small animal imaging." IEEE Transactions on Nuclear Science 50, no. 1 (2003): 74–79. http://dx.doi.org/10.1109/tns.2002.807949.

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41

Kastis, G. A., L. R. Furenlid, D. W. Wilson, T. E. Peterson, H. B. Barber, and H. H. Barrett. "Compact CT/SPECT Small-Animal Imaging System." IEEE Transactions on Nuclear Science 51, no. 1 (2004): 63–67. http://dx.doi.org/10.1109/tns.2004.823337.

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42

Diana, A., M. Pivetta, and M. Cipone. "Imaging Evaluation of the Small Animal Mediastinum." Veterinary Research Communications 30, S1 (2006): 145–51. http://dx.doi.org/10.1007/s11259-006-0028-6.

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43

Pomper, Martin G. "Can small animal imaging accelerate drug development?" Journal of Cellular Biochemistry 87, S39 (2002): 211–20. http://dx.doi.org/10.1002/jcb.10443.

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44

Schellingerhout, Dawid, Roberto Accorsi, Umar Mahmood, John Idoine, Richard C. Lanza, and Ralph Weissleder. "Coded Aperture Nuclear Scintigraphy: A Novel Small Animal Imaging Technique." Molecular Imaging 1, no. 4 (2002): 153535002002213. http://dx.doi.org/10.1162/15353500200221362.

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We introduce and demonstrate the utility of coded aperture (CA) nuclear scintigraphy for imaging small animals. CA imaging uses multiple pinholes in a carefully designed mask pattern, mounted on a conventional gamma camera. System performance was assessed using point sources and phantoms, while several animal experiments were performed to test the usefulness of the imaging system in vivo, with commonly used radiopharmaceuticals. The sensitivity of the CA system for 99mTc was 4.2 × 103 cps/Bq (9400 cpm/μCi), compared to 4.4 × 104 cps/Bq (990 cpm/μCi) for a conventional collimator system. The sy

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45

Kersemans, Veerle, Stuart Gilchrist, Philip Danny Allen, et al. "A System-Agnostic, Adaptable and Extensible Animal Support Cradle System for Cardio-Respiratory-Synchronised, and Other, Multi-Modal Imaging of Small Animals." Tomography 7, no. 1 (2021): 39–54. http://dx.doi.org/10.3390/tomography7010004.

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Standardisation of animal handling procedures for a wide range of preclinical imaging scanners will improve imaging performance and reproducibility of scientific data. Whilst there has been significant effort in defining how well scanners should operate and how in vivo experimentation should be practised, there is little detail on how to achieve optimal scanner performance with best practices in animal welfare. Here, we describe a system-agnostic, adaptable and extensible animal support cradle system for cardio-respiratory-synchronised, and other, multi-modal imaging of small animals. The anim

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46

Graves, E., R. Weissleder, and V. Ntziachristos. "Fluorescence Molecular Imaging of Small Animal Tumor Models." Current Molecular Medicine 4, no. 4 (2004): 419–30. http://dx.doi.org/10.2174/1566524043360555.

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47

IMAI, Hirohiko, Atsuomi KIMURA, and Hideaki FUJIWARA. "Small Animal Imaging with Hyperpolarized 129Xe Magnetic Resonance." Analytical Sciences 30, no. 1 (2014): 157–66. http://dx.doi.org/10.2116/analsci.30.157.

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48

Bentolila, L. A., Y. Ebenstein, and S. Weiss. "Quantum Dots for In Vivo Small-Animal Imaging." Journal of Nuclear Medicine 50, no. 4 (2009): 493–96. http://dx.doi.org/10.2967/jnumed.108.053561.

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49

Piscaer, T. M., G. J. V. M. van Osch, J. A. N. Verhaar, and H. Weinans. "Imaging of experimental osteoarthritis in small animal models." Biorheology 45, no. 3-4 (2008): 355–64. http://dx.doi.org/10.3233/bir-2008-0482.

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50

Park, J. M., and S. S. Gambhir. "Multimodality Radionuclide, Fluorescence, and Bioluminescence Small-Animal Imaging." Proceedings of the IEEE 93, no. 4 (2005): 771–83. http://dx.doi.org/10.1109/jproc.2005.844263.

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