Log in

Relevant bibliographies by topics / Small inhibitory compounds

Contents

Journal articles
Dissertations / Theses
Books
Book chapters
Conference papers
Reports

Academic literature on the topic 'Small inhibitory compounds'

Author: Grafiati

Published: 15 June 2024

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Small inhibitory compounds.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Small inhibitory compounds"

1

Yan, Hua, Tomoko Chiba Mizutani, Nobuhiko Nomura, et al. "A Novel Small Molecular Weight Compound with a Carbazole Structure That Demonstrates Potent Human Immunodeficiency Virus Type-1 Integrase Inhibitory Activity." Antiviral Chemistry and Chemotherapy 16, no. 6 (2005): 363–73. http://dx.doi.org/10.1177/095632020501600603.

Full text

Abstract:

The integration of reverse transcribed proviral DNA into a host genome is an essential event in the human immunodeficiency virus type 1 (HIV-1) replication life cycle. Therefore, the viral enzyme integrase (IN), which plays a crucial role in the integration event, has been an attractive target of anti-retroviral drugs. Several IN inhibitory compounds have been reported previously, yet none has been successful in clinical use. To find a new, more successful IN inhibitor, we screened a diverse library of 12000 small molecular weight compounds randomly by in vitro strand-transfer assay. We identi

APA, Harvard, Vancouver, ISO, and other styles

2

Alvarez-Gonzalez, Juan Antonio, Robert Maul, Rahul M. Kohli, and Patricia J. Gearhart. "Small molecule inhibitors of Activation-Induced Deaminase." Journal of Immunology 200, no. 1_Supplement (2018): 48.18. http://dx.doi.org/10.4049/jimmunol.200.supp.48.18.

Full text

Abstract:

Abstract Activation-Induced Deaminase (AID) is a cytosine deaminase that converts cytosine into uracil in DNA, which initiates a cascade of mutagenic DNA repair to introduce point mutations and double-strand breaks. Specific targeting of AID to the immunoglobulin heavy chain locus promotes somatic hypermutation in antibody variable genes for affinity maturation, and breaks in switch regions for class switch recombination (CSR). However, mis-targeting of AID to other loci could initiate tumor development and lead to greater drug resistance among cancer cells when continually expressed. To ident

APA, Harvard, Vancouver, ISO, and other styles

3

Asai, Takashi, Tsutomu Takeuchi, Jeff Diffenderfer, and L. David Sibley. "Identification of Small-Molecule Inhibitors of Nucleoside Triphosphate Hydrolase in Toxoplasma gondii." Antimicrobial Agents and Chemotherapy 46, no. 8 (2002): 2393–99. http://dx.doi.org/10.1128/aac.46.8.2393-2399.2002.

Full text

Abstract:

ABSTRACT Approximately 150,000 small-molecule compounds were tested by a robotic screening assay for their ability to inhibit nucleoside triphosphate hydrolase (NTPase), a novel enzyme of the tachyzoite form of Toxoplasma gondii. Five unrelated species of compounds were found to inhibit the activities of both NTPase isoforms (NTPase isoform I [NTPase-I] and NTPase-II). The 50% inhibitory concentrations (IC50s) ranged from 0.1 to 20 μM, and in general, the IC50s were similar for both NTPase isoforms. However, the activity of NTPase-I was 20 times more sensitive than the activity of NTPase-II to

APA, Harvard, Vancouver, ISO, and other styles

4

Patkar, Chinmay G., Martha Larsen, Michael Owston, Janet L. Smith, and Richard J. Kuhn. "Identification of Inhibitors of Yellow Fever Virus Replication Using a Replicon-Based High-Throughput Assay." Antimicrobial Agents and Chemotherapy 53, no. 10 (2009): 4103–14. http://dx.doi.org/10.1128/aac.00074-09.

Full text

Abstract:

ABSTRACT Flaviviruses cause severe disease in humans and are a public health priority worldwide. However, no effective therapies or drugs are commercially available yet. Several flavivirus replicon-based assays amenable to high-throughput screening of inhibitors have been reported recently. We developed and performed a replicon-based high-throughput assay for screening small-molecule inhibitors of yellow fever virus (YFV) replication. This assay utilized packaged pseudoinfectious particles containing a YFV replicon that expresses Renilla luciferase in a replication-dependent manner. Several sm

APA, Harvard, Vancouver, ISO, and other styles

5

Han, Chun, Jiahong Ren, Feng Su, et al. "Hybrids of Quinoline and Anilinopyrimidine: Novel EGFRT790M Inhibitors with Antiproliferative Activity against Non-Small Cell Lung Cancer Cell Lines." Anti-Cancer Agents in Medicinal Chemistry 20, no. 6 (2020): 724–33. http://dx.doi.org/10.2174/1871520620666200302113206.

Full text

Abstract:

Background: The third-generation irreversible Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors (TKIs) inhibit the T790M mutation while sparing EGFRWT. However, the C797S point mutation confers resistance to existing irreversible EGFRT790M inhibitors. Objective: Novel EGFRT790M inhibitors were designed through hybridization of quinoline and anilinopyrimidine, and biologically evaluated their antiproliferative activity against Non-Small Cell Lung Cancer (NSCLC) cell lines. Methods: The target compounds 11a-h were synthesized and structurally characterized with 1H, 13C Nuclear M

APA, Harvard, Vancouver, ISO, and other styles

6

Shen, Hao, Shiqi Liu, Limin Shang, et al. "Discovery of Small-Molecule Inhibitors Against Norovirus 3CLpro Using Structure-Based Virtual Screening and FlipGFP Assay." Viruses 17, no. 6 (2025): 814. https://doi.org/10.3390/v17060814.

Full text

Abstract:

Norovirus, a major cause of acute gastroenteritis, possesses a single-stranded positive-sense RNA genome. The viral 3C-like cysteine protease (3CLpro) plays a critical role in processing the viral polyprotein into mature non-structural proteins, a step essential for viral replication. Targeting 3CLpro has emerged as a promising strategy for developing small-molecule inhibitors against Norovirus. In this study, we employed a combination of virtual screening and the FlipGFP assay to identify potential inhibitors targeting the 3CLpro of Norovirus genotype GII.4. A library of approximately 58,800

APA, Harvard, Vancouver, ISO, and other styles

7

Abramić, Marija, and Dejan Agić. "Survey of Dipeptidyl Peptidase III Inhibitors: From Small Molecules of Microbial or Synthetic Origin to Aprotinin." Molecules 27, no. 9 (2022): 3006. http://dx.doi.org/10.3390/molecules27093006.

Full text

Abstract:

Dipeptidyl peptidase III (DPP III) was originally thought to be a housekeeping enzyme that contributes to intracellular peptide catabolism. More specific roles for this cytosolic metallopeptidase, in the renin-angiotensin system and oxidative stress regulation, were confirmed, or recognized, only recently. To prove indicated (patho)physiological functions of DPP III in cancer progression, cataract formation and endogenous pain modulation, or to reveal new ones, selective and potent inhibitors are needed. This review encompasses natural and synthetic compounds with experimentally proven inhibit

APA, Harvard, Vancouver, ISO, and other styles

8

Noueiry, Amine O., Paul D. Olivo, Urszula Slomczynska, et al. "Identification of Novel Small-Molecule Inhibitors of West Nile Virus Infection." Journal of Virology 81, no. 21 (2007): 11992–2004. http://dx.doi.org/10.1128/jvi.01358-07.

Full text

Abstract:

ABSTRACT West Nile virus (WNV) has spread throughout the United States and Canada and now annually causes a clinical spectrum of human disease ranging from a self-limiting acute febrile illness to acute flaccid paralysis and lethal encephalitis. No therapy or vaccine is currently approved for use in humans. Using high-throughput screening assays that included a luciferase expressing WNV subgenomic replicon and an NS1 capture enzyme-linked immunosorbent assay, we evaluated a chemical library of over 80,000 compounds for their capacity to inhibit WNV replication. We identified 10 compounds with

APA, Harvard, Vancouver, ISO, and other styles

9

Lefas, Georgia, and George Chaconas. "High-Throughput Screening Identifies Three Inhibitor Classes of the Telomere Resolvase from the Lyme Disease Spirochete." Antimicrobial Agents and Chemotherapy 53, no. 10 (2009): 4441–49. http://dx.doi.org/10.1128/aac.00529-09.

Full text

Abstract:

ABSTRACT Lyme disease, the most common vector-borne zoonosis in North America, is caused by the spirochetal pathogen Borrelia burgdorferi. The telomere resolvase encoded by this organism (ResT) promotes the formation of covalently closed hairpin ends on the linear DNA molecules of B. burgdorferi through a two-step transesterification. ResT is essential for survival and is therefore an attractive target for the development of highly specific antiborrelial drugs. To identify ResT inhibitors, a novel fluorescence-based high-throughput assay was developed and used to screen a library of 27,520 sma

APA, Harvard, Vancouver, ISO, and other styles

10

Ercan-Fang, Nacide, Miriam R. Taylor, Judith L. Treadway, et al. "Endogenous effectors of human liver glycogen phosphorylase modulate effects of indole-site inhibitors." American Journal of Physiology-Endocrinology and Metabolism 289, no. 3 (2005): E366—E372. http://dx.doi.org/10.1152/ajpendo.00264.2004.

Full text

Abstract:

Phosphorylase is regulated by a number of small-molecular-weight effectors that bind to three sites on the enzyme. Recently, a fourth site referred to as the indole-inhibitor site has been identified. Synthetic compounds bind to the site and inhibit activity. However, the effects of these compounds in the presence of other endogenous effectors are unknown. We have determined the effects of four indole derivative glycogen phosphorylase inhibitors (GPI) on recombinant human liver glycogen phosphorylase a activity. The GPIs tested were all potent inhibitors. However, the endogenous inhibitors (gl

APA, Harvard, Vancouver, ISO, and other styles

More sources

Dissertations / Theses on the topic "Small inhibitory compounds"

1

He, Fei, and 贺斐. "In vitro growth inhibitory effects of arsenic trioxide in non-small cell lung cancer with different epidermal growth factor receptormutations." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45860063.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Richmond, Oliver H. III. "Extraction, Purification and Evaluation of PRMT5-Inhibitory Phytochemical Compounds for the Treatment of Prostate Adenocarcinoma." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2019. http://digitalcommons.auctr.edu/cauetds/185.

Full text

Abstract:

The development and advancement of prostate cancer is supported by a plethora of genetic and proteomic abnormalities, including events of post-translational modifications. The protein arginine methyltransferase 5 (PRMT5) enzyme regulates epigenetic events of histone modifications and protein post-translational modifications within protein signaling pathways. PRMT5 functions by catalyzing the symmetric dimethylation of terminal arginine residues on target protein substrates. Under abnormal conditions of overexpression and upregulation, PRMT5 methyltransferase activity constitutively drives the

APA, Harvard, Vancouver, ISO, and other styles

3

García, Reyes Balbina [Verfasser]. "Validation of new Casein Kinase 1 (CK1) small molecule inhibitor compounds and characterization of Inhibitors of Wnt Production (IWPs) as inhibitors of CK1δ / Balbina García Reyes". Ulm : Universität Ulm, 2018. http://d-nb.info/1151938424/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Mohamed, Safwat. "Parallel synthesis of small molecule compound libraries : isoform selective Rho-Kinase inhibitors." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54300.

Full text

Abstract:

The objective of this thesis was to use parallel synthesis to build small molecule libraries of novel compounds with potential as isoform selective type II rho-kinase (ROCK1/2) inhibitors. Considerable effort is ongoing to identify isoform selective ROCK inhibitors, as hyperactivity of the ROCK is implicated in cardiovascular diseases, cancer, diabetes and many other diseases that affect millions of Canadians, and billions of people worldwide. In the absence the extensive structural details of the type II kinase inhibitor binding mode, we have used an empirical approach to the design of type I

APA, Harvard, Vancouver, ISO, and other styles

5

Strand, Mårten. "The discovery of antiviral compounds targeting adenovirus and herpes simplex virus : assessment of synthetic compounds and natural products." Doctoral thesis, Umeå universitet, Virologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-88186.

Full text

Abstract:

There is a need for new antiviral drugs. Especially for the treatment of adenovirus infections, since no approved anti-adenoviral drugs are available. Adenovirus infections in healthy persons are most often associated with respiratory disease, diarrhea and infections of the eye. These infections can be severe, but are most often self-limiting. However, in immunocompromised patients, adenovirus infections are associated with morbidity and high mortality rates. These patients are mainly stem cell or bone marrow transplantation recipients, however solid organ transplantation recipients or AIDS pa

APA, Harvard, Vancouver, ISO, and other styles

6

Nikjoo, Dariush. "Design and Synthesis of a Small Set of Thiourea-based Compounds as Inhibitors of AChE1 from Mosquitoes." Thesis, Umeå universitet, Kemiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-92551.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Stoup, Nicolas. "Rôle des domaines EGF de la mucine MUC4 dans la relation structure-fonction et le ciblage thérapeutique du complexe oncogénique MUC4-ErbB2 dans l'adénocarcinome pancréatique." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS065.

Full text

Abstract:

Le cancer du pancréas représente la 4e cause de mortalité par cancer dans le monde. C'est une pathologie fortement létale, dont la survie à 5 ans n'excède pas 10%. Ce pronostic sombre s'explique majoritairement par un diagnostic tardif de la maladie, le plus souvent à des stades métastatiques ou localement avancés (80 % des patients au diagnostic), mais aussi et surtout par un manque de thérapies efficaces. En effet, les thérapies ciblées, notamment celles visant le récepteur ErbB2 (surexprimé dans ce cancer), ainsi que les chimiothérapies conventionnelles (FOLFIRINOX, gemcitabine, Nab-paclita

APA, Harvard, Vancouver, ISO, and other styles

8

Garbom, Sara. "A strategy to identify novel antimicrobial compounds : a bioinformatics and HTS approach." Doctoral thesis, Umeå : Department of Molecular Biology, Umeå University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-900.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Merkle, Ruth [Verfasser], and Ursula [Akademischer Betreuer] Klingmüller. "Impact of growth factors, therapeutic inhibitors and cytostatic compounds on the response of non-small-cell lung carcinoma cell lines / Ruth Merkle ; Betreuer: Ursula Klingmüller." Heidelberg : Universitätsbibliothek Heidelberg, 2015. http://d-nb.info/1180396413/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Schmidt, Thomas Christian. "Theoretical Investigations on the Interactions of Small Compounds with their Molecular Environments." Doctoral thesis, 2015. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-127860.

Full text

Abstract:

Im ersten Teil dieser Arbeit wird eine Kombination theoretischer Methoden für die strukturbasierte Entwicklung neuer Wirkstoffe präsentiert. Ausgehend von der Kristallstruktur eines kovalenten Komplexes einer Modellverbindung mit dem Zielprotein wurde mit Hilfe von quantenmechanischen und QM/MM Rechnungen die genaue Geometrie des vorausgehenden nicht-kovalenten Komplexes betimmt. Letztere ist der bestimmende Faktor für die Reaktivität des Inhibitors gegenüber der katalytisch aktiven Aminosäure und damit für die Ausbildung einer kovalenten Bindung. Aus diesem Grund wurde diese Geometrie auch fü

APA, Harvard, Vancouver, ISO, and other styles

Books on the topic "Small inhibitory compounds"

1

Woywodt, Alexander, and Diana Chiu. Drug-induced and toxic glomerulopathies. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0082.

Full text

Abstract:

Glomerulopathies induced by particular exogenous compounds or molecules include those attributable to toxicity, and those caused by inducing an immune or autoimmune response. Tubules are more commonly the target of toxicity as they absorb and concentrate components of filtrate. Damage to endothelial cells may account for thrombotic microangiopathy in response to calcineurin inhibitors. Endothelial cells are also likely to be the target in drug-induced small vessel vasculitis. Toxicity to podocytes accounts for focal segmental glomerulosclerosis caused by pamidronate and other agents. Chloroqui

APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Small inhibitory compounds"

1

Workman, Paul. "Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-40204-4_11.

Full text

Abstract:

Abstract This personal perspective focuses on small-molecule inhibitors of proteostasis networks in cancer—specifically the discovery and development of chemical probes and drugs acting on the molecular chaperones HSP90 and HSP70, and on the HSF1 stress pathway. Emphasis is on progress made and lessons learned and a future outlook is provided. Highly potent, selective HSP90 inhibitors have proved invaluable in exploring the role of this molecular chaperone family in biology and disease pathology. Clinical activity was observed, especially in non small cell lung cancer and HER2 positive breast

APA, Harvard, Vancouver, ISO, and other styles

2

Ferrari, Stefania, Federica Pellati, and Maria Paola Costi. "Protein–Protein Interaction Inhibitors: Case Studies on Small Molecules and Natural Compounds." In Disruption of Protein-Protein Interfaces. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-37999-4_2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Kakkar, Rita. "In silico design of PDHK inhibitors: From small molecules to large fluorinated compounds." In Computational Chemistry Methodology in Structural Biology and Materials Sciences. Apple Academic Press, 2017. http://dx.doi.org/10.1201/9781315207544-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Hoffer, Laurent, Philippe Roche, and Xavier Morelli. "Rational Design of PDZ Domain Inhibitors: Discovery of Small Organic Compounds Targeting PDZ Domains." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1166-1_16.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Shuldau, Mikita A., Artsemi M. Yushkevich, Ivan P. Bosko, Alexander V. Tuzikov, and Alexander M. Andrianov. "Generative Autoencoders for Designing Novel Small-Molecule Compounds as Potential SARS-CoV-2 Main Protease Inhibitors." In Communications in Computer and Information Science. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-98883-8_9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Nock, Berthold A., and Theodosia Maina. "Theranostic Radiopeptides in Nuclear Oncology: Design, Preclinical Screening, and Clinical Translation." In Beyond Becquerel and Biology to Precision Radiomolecular Oncology: Festschrift in Honor of Richard P. Baum. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-33533-4_22.

Full text

Abstract:

AbstractCancer theranostics is an emerging and exciting field in nuclear medicine, whereby suitably designed radionuclide carriers, after injection to patients, seek and specifically interact with biomolecular targets overexpressed on cancer cells. When a diagnostic radionuclide is applied, molecular imaging with SPECT (gamma emitter) or PET (positron emitter) will reveal tumor lesions, allowing for initial diagnosis and assessment of disease spread and progression. Hence, molecular imaging represents a reliable tool for patient stratification, dosimetry and planning of therapy that follows ne

APA, Harvard, Vancouver, ISO, and other styles

7

A. Elrashedy, Ahmed. "Targeting Inhibitor of Enterococcus faecalis: Insights from Comparative Molecular Dynamics and Binding Free Energy Analyses." In Infectious Diseases. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.114329.

Full text

Abstract:

For the past 50 years, antibiotics that target DNA gyrase have proven to be clinically successful. As a result, the search for novel gyrase inhibitors has intensified due to the rise in bacterial resistance. Since it is absent in eukaryotes yet essential in all bacteria, anti-bacterials target it aggressively. Although quinolones are a clinically approved medication, both Gram-positive and Gram-negative bacteria are developing resistance to them, which compromises their therapeutic efficacy. Thus, it is vital to identify novel compounds that can efficiently inhibit DNA gyrase. A recent experim

APA, Harvard, Vancouver, ISO, and other styles

8

Selvakumar, P., Santosh Kumar Nathsharma, and Sumanta Bhattacharya. "Small Molecule Inhibitors." In Advances in Medical Diagnosis, Treatment, and Care. IGI Global, 2025. https://doi.org/10.4018/979-8-3693-7728-4.ch017.

Full text

Abstract:

Small molecule inhibitors represent a cornerstone of modern pharmaceutical and biomedical research, offering targeted therapeutic interventions against a wide array of diseases by modulating specific molecular targets within cells. Defined by their molecular size, typically less than 900 daltons, these compounds interact selectively with proteins, enzymes, receptors, or other biomolecules involved in disease pathways. The concept of small molecule inhibition revolves around disrupting or altering the activity of these targets, thereby influencing cellular processes critical for disease progres

APA, Harvard, Vancouver, ISO, and other styles

9

Telang, Nitin. "Stem Cell Models: Novel Experimental Approach for Testable Alternatives against Therapy-resistant Breast and Colon Cancer." In Functional Foods for Health Maintenance: Understanding their Role in Cancer Prevention. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815179217123010018.

Full text

Abstract:

Breast and colon cancer represent the leading causes of mortality in developed countries. The treatment options for these organ site cancers differ depending on the status of hormone/growth factor receptors in molecular subtypes that exhibit altered expression of oncogenes/tumor suppressor genes and growth factormediated molecular pathways. Conventional cytotoxic chemo-endocrine therapy traditionally includes the use of anthracyclin, taxol, cisplatin, anti-estrogens, antifolates and DNA anti-metabolites. Additionally, the use of molecular pathway-specific small molecule inhibitors represents e

APA, Harvard, Vancouver, ISO, and other styles

10

Chen, Dong, Joshua Ray, Tomasz Cierpicki, and Jolanta Grembecka. "Menin Inhibitors: Discovery, Development and Clinical Translation." In Epigenetic Drug Discovery. Royal Society of Chemistry, 2024. http://dx.doi.org/10.1039/9781837674916-00596.

Full text

Abstract:

The protein–protein interaction between menin and Mixed Lineage Leukemia 1 (MLL1) protein plays a critical role in a subset of acute leukemia, including leukemias with MLL1 translocations or mutations in the nucleophosmin (NPM1) gene, providing an opportunity for therapeutic intervention. Indeed, multiple small molecule inhibitors directly targeting menin to block its interactions with MLL1 were reported within the last decade. These compounds demonstrate pronounced anti-leukemic activity in pre-clinical models of MLL1-rearranged and NPM1-mutated leukemia, resulting in clinical translation of

APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Small inhibitory compounds"

1

Wang, Xi, Shuai Ren, Yi He, et al. "Effect of Organic Solvent on Corrosion Inhibition of Mild Steel in CO2 Environment." In CONFERENCE 2022. AMPP, 2022. https://doi.org/10.5006/c2022-17942.

Full text

Abstract:

Abstract Injection of inhibitors is an economic and efficient way to combat corrosion of tubular steels utilized in the production and transmission of oil and gas. Given variability in the physicochemical environments encountered in the field, small scale laboratory testing is necessary to determine the effectiveness of inhibitors in specific corrosive environments. To achieve ppm concentrations of an inhibitor in a small-scale lab setup, the inhibitor often needs to be pre-diluted before addition to the test electrolyte, which has the potential to introduce experimental errors. One factor tha

APA, Harvard, Vancouver, ISO, and other styles

2

Wang, H., B. Brown, S. Nesic, and A. Pailleret. "Investigation of Inhibitor Adsorption Mechanism by in Situ Tapping Mode Atomic Force Microscopy." In CORROSION 2021. AMPP, 2021. https://doi.org/10.5006/c2021-16610.

Full text

Abstract:

ABSTRACT Inhibition of internal corrosion is essential for assuring asset integrity of oil and gas transportation pipelines. Among the various types of inhibitors, the organic corrosion inhibitors are the most widely used in oilfield applications. Consequently, it is necessary to understand the adsorption mechanism and corrosion inhibition capabilities of organic inhibitors. Although the corrosion inhibition mechanisms of organic inhibitors have been extensively investigated by electrochemistry analysis, the adsorption modes and film properties of corrosion inhibitors have rarely been studied

APA, Harvard, Vancouver, ISO, and other styles

3

Obeyesekere, Nihal, and Thusitha Wickramarachchi. "Transition from Combinatorial Chemistry to Present Day Robotics in Product Development for Oil Field Chemicals." In MECC 2023. AMPP, 2023. https://doi.org/10.5006/mecc2023-20245.

Full text

Abstract:

Abstract In this paper, the slow evolution of combinatorial chemistry from its dawn in 1980’s to today’s oil field product development is discussed. Combinatorial chemistry comprises chemical synthetic methods that make it possible to prepare a vast number of compounds in a single process. These compound libraries can be made as mixtures, sets of individual compounds or chemical structures generated by computer software. This phenomenon was first invented by Arpad Furka (Lorand University, Budapest) in 1982. He described the principle of it, the combinatorial synthesis and a deconvolution proc

APA, Harvard, Vancouver, ISO, and other styles

4

Singla, Kushal, Hubert Perrot, Bruce Brown, and Srdjan Nesic. "Adsorption of Model Inhibitor Compound Characterized Using Quartz Crystal Microbalance with Dissipation Monitoring." In CONFERENCE 2023. AMPP, 2023. https://doi.org/10.5006/c2023-19145.

Full text

Abstract:

Abstract Although inhibitor adsorption and inhibition mechanisms have been studied extensively using various electrochemical techniques, these electrochemical techniques only provide an indirect estimate of inhibitor adsorption. In the present study, a QCM with dissipation monitoring (QCM-D) was used to investigate the adsorption on gold coated quartz crystal resonator (QCR) of a model corrosion inhibitor (CI) compound at different bulk inhibitor concentrations. In a first step, the classical Sauerbrey’s equation was used to analyze the normalized frequency change data for estimation of adsorb

APA, Harvard, Vancouver, ISO, and other styles

5

Gulbrandsen, Egil, and Jean-Hervé Morard. "Why Does Glycol Inhibit CO2 Corrosion?" In CORROSION 1998. NACE International, 1998. https://doi.org/10.5006/c1998-98221.

Full text

Abstract:

Abstract CO2 corrosion of carbon steel and its inhibition in mixtures of water and ethylene glycol (MEG) or diethylene glycol (DEG) has been studied at 1 bar CO2, 25 °C, pH 5 under natural convection conditions. Corrosion rates predicted by the glycol at 1 bar CO2,25 °C, pH 5 under natural convection agreement with the experimental results. Analysis of the experimental results shows that the corrosion inhibitor effect of MEG and DEG can be correlated to changes in solution properties with increasing MEG or DEG concentration, such as decreased CO2 solubility, decreased CO2 diffusivity / increas

APA, Harvard, Vancouver, ISO, and other styles

6

Schmitt, Guenter, and Ruediger Forster. "Unexpected Effect of Small Oxygen Concentrations in Sales Gas on Element Currents between Pipeline Steel and Magnetite from Black Powder." In CORROSION 2015. NACE International, 2015. https://doi.org/10.5006/c2015-05587.

Full text

Abstract:

Abstract Magnetite as the major part of black powder encountered in transmission pipelines all over the world can form galvanic elements with the pipeline steel, provided a liquid film with some ionic conductivity is present. This galvanic element can exist also in the absence of water, provided other compounds are present to assure some ionic conductivity, e.g. organic acids like formic acid, acetic acid, acetates, or ammonium compounds from inhibitor packages. In this galvanic element iron forms the anode and magnetite the surface for the cathodic reaction. The element currents are in the µA

APA, Harvard, Vancouver, ISO, and other styles

7

Holden, Jim, Andrea Hansen, Alla Furman, Rita Kharshan, and Elizabeth Austin. "Vapor Corrosion Inhibitors in Hydro-Testing and Long Term Storage Applications." In CORROSION 2010. NACE International, 2010. https://doi.org/10.5006/c2010-10405.

Full text

Abstract:

Abstract Hydro-testing or hydrostatic testing of metallic equipment such as vessels, piping, valves etc. is an important method for quality control of parts, after production and during use. When water is used in these tests, corrosion of the metal, during and after testing is a concern. Vapor-phase corrosion inhibitors (VCI), when added to water in small concentrations are able to prevent corrosion during testing, during wet storage and after testing. The mechanism of amino-carboxylate based vapor-phase corrosion inhibitors is to prevent corrosion of metals in three phases: within the solutio

APA, Harvard, Vancouver, ISO, and other styles

8

Agarwal, D. C., Lee Stewart, and Mike McAllister. "Alloy 602CA(UNS N06025) Solves Pig Tail Corrosion Problems in Refineries." In CORROSION 2003. NACE International, 2003. https://doi.org/10.5006/c2003-03656.

Full text

Abstract:

Abstract In high temperature corrosion, besides oxygen and nitrogen attack, alloys frequently encounter attack by carbon species. This attack can take two forms namely carburization and metal dusting (some times referred to as catastrophic carburization). Carburization generally occurs at carbon activities less than 1 and at temperatures typically greater than 800° to 850°C and may result in alloy embrittlement due to formation of internal carbides. Metal Dusting on the other hand, leads to rapid wastage, thinning and disintegration of alloys into graphite, metal particles, and possibly carbid

APA, Harvard, Vancouver, ISO, and other styles

9

Alsawaf, Shahed, Tuğba Bal, and Zihni Onur Çalışkaner. "EXPLORING THE POTENTIAL OF DRUG REPURPOSING AGAINST ABNORMALLY REGULATED CELL-MATRIX INTERACTIONS IN THE TREATMENT OF PANCREATIC CANCER (A COMPUTATIONAL STUDY)." In STRA International Conference on Engineering & Technology, 09-10 October 2024, Istanbul. Global Research & Development Services, 2024. https://doi.org/10.20319/icstr.2024.9192.

Full text

Abstract:

Pancreatic ductal adenocarcinoma (PDAC) represents one of the most aggressive cancers, with a 5-year survival rate of only 8%. The progression of the disease is significantly influenced by the tumor microenvironment, especially by cell-extracellular matrix (ECM) interactions. The aim of this study is to repurpose small molecules as inhibitor candidates to jointly target key receptors for the ECM attachment, specifically discoidin domain receptors (DDR1 and DDR2), which are implicated in promoting tumor growth through cell-collagen interactions.Using a computational drug repurposing framework,

APA, Harvard, Vancouver, ISO, and other styles

10

Yang, Jiang, and Xintong Wang. "Effect of Thio-Chemicals Molecular Structure for Corrosion Inhibition in CO2 Corrosive Environments." In SPE International Conference on Oilfield Chemistry. SPE, 2023. http://dx.doi.org/10.2118/213847-ms.

Full text

Abstract:

Abstract Carbon dioxide often exists in oil and gas fields, and CO2 flooding is also increasingly used to enhance oil recovery. CO2 is highly corrosive to steel in oilfield fluid. The effective and economical method for controlling corrosion is the addition of corrosion inhibitors for carbon steel materials. Small thio-compounds have been found effective to enhance corrosion inhibition of imidazoline inhibitors. In this study, several small thio-derivatives inhibitor including mercaptoethanol (ME), thiourea (TU), and mercaptoacetic acid (TGA) and 2-mercaptobenzimidazole (MBI) were compared to

APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Small inhibitory compounds"

1

Yompakdee, Chulee, and Warintorn Chavasiri. An active compound Kempferia parviflora with inhibitory activity against GSK-3 kinase implicated in type II Diabetes and Alzheimer's disease. Chulalongkorn University, 2015. https://doi.org/10.58837/chula.res.2015.37.

Full text

Abstract:

Calcium signaling pathways play pivotal roles in regulation of various important biological processes in eukaryotes ranging from yeast to human. Because of the high degree in gene conservation from yeast to human, the small molecule inhibitors discovered in the yeast based-drug screening system can be expected to exert their function in human as well. The immunosuppressive agents, FK506 and cyclosporine A, are an example. Our previous studies using a zds1 yeast-based assay to search for inhibitors in the calcium signaling pathway in Saccharomyces cerevisae mutant strain from the crude extract

APA, Harvard, Vancouver, ISO, and other styles

2

Chamovitz, Daniel A., and Zhenbiao Yang. Chemical Genetics of the COP9 Signalosome: Identification of Novel Regulators of Plant Development. United States Department of Agriculture, 2011. http://dx.doi.org/10.32747/2011.7699844.bard.

Full text

Abstract:

This was an exploratory one-year study to identify chemical regulators of the COP9 signalosome. Chemical Genetics uses small molecules to modify or disrupt the function of specific genes/proteins. This is in contrast to classical genetics, in which mutations disrupt the function of genes. The underlying concept is that the functions of most proteins can be altered by the binding of a chemical, which can be found by screening large libraries for compounds that specifically affect a biological, molecular or biochemical process. In addition to screens for chemicals which inhibit specific biologic

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!