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Dissertations / Theses on the topic 'Small molecule modulators'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Luccarelli, James. "Small Molecule Modulators of Apoptosis." Thesis, Harvard University, 2017. http://nrs.harvard.edu/urn-3:HUL.InstRepos:32676118.

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Control of cell survival relies on a delicate balance between pro-apoptotic and anti-apoptotic signalling. In humans, the key regulatory proteins are those of the BCL-2 family, which include effector proteins such as BAX and BAK, anti-apoptotic proteins including BCL-2 and MCL-1, and pro-apoptotic proteins including BID and BIM. Dysregulation of apoptosis is among the Hallmarks of Cancer, and modulation of apoptosis holds promise as an effective therapeutic strategy for a range of malignancies. This thesis advances new strategies for modulating apoptosis using small molecules. The first secti

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2

Moustakim, Moses. "Discovery of small molecule epigenetic modulators." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:0d4a42f1-8a47-4ad5-ac30-b4eaf0d36db3.

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Target validation is increasingly becoming a central tenet to successful execution of drug discovery campaigns. An emerging approach towards the development of novel therapies for previously untreated diseases is the development of small molecule chemical probes which can be used as early stage tools for pertinent biological questions to be explored about a molecular target within the context of disease. A number of proteins which regulate epigenetic mechanisms have been correlated with disease onset and progression. Despite disease links, there remains a paucity in the understanding by which

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3

Liu, Jia. "Mechanistic studies of small-molecule CFTR modulators." Thesis, University of Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627986.

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The cystic fibrosis transmembrane conductance regulator (CFTR) is a CI channel found in the apical membrane of epithelial cells. CFTR activity is tightly controlled by complex regulation. However, CFTR overactivity or loss-of-function mutations in CFTR are both disease causing conditions. The aims of my research were to investigate the mechanisms Of action of small-molecule CFTR modulators that regulate CFTR function. Loop diuretics are inhibitors ofNa+-K+-2Cr-cotranspOlter isofOlm 1 (NKCC1) located in the basolateral membrane of epithelial cells. I demonstrated that loop diuretics also inhibi

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4

Rütschlin, Sina [Verfasser]. "Small Molecule Modulators of Bacterial Swarming Behavior / Sina Rütschlin." Konstanz : KOPS Universität Konstanz, 2019. http://d-nb.info/1189586592/34.

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5

Tampi, Girish. "Investigating small molecule modulators of bio-molecular interactions : an in-silico study." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/12511/.

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Small molecule inhibitors are commonly used to target protein targets that assist in the spread of diseases such as AIDS, cancer and deadly forms of influenza. Despite drug companies spending millions on R&D, the number of drugs that pass clinical trials is limited due to difficulties in engineering optimal non-covalent interactions. As many protein targets have the ability to rapidly evolve resistance, there is an urgent need for methods that rapidly identify effective new compounds. The thermodynamic driving force behind most biochemical reactions is known as the Gibbs free energy and it con

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6

Yuan, Yuan. "Small-Molecule Modulators of Pancreatic Ductal Cells: Histone Methyltransferases and \(\beta\)-Cell Transdifferentiation." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10637.

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Small molecules are important not only for treating human diseases but also for studying disease-related biological processes. This dissertation focuses on the effects of small molecules on pancreatic ductal adenocarcinoma cells. Here, I describe the discovery of two small-molecule tool compounds and their applications for interrogating the biological processes related to two distinct diseases in the human pancreas. First, BRD4770 was identified as a histone methyltransferase inhibitor through a target-based biochemical approach, and was used as a probe to study the function of methyltransfera

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7

Paulk, Joshiawa Lanair James. "Modulators of Cellular and Biochemical PRC2 Activity." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13064968.

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EZH2 is a SET domain-containing methyltransferase and the catalytic component of the multimeric Polycomb- group (PcG) protein complex, PRC2. When in complex with other PRC2 members (EED, SUZ12, AEBP2, and RBBP4), EZH2 catalyzes methylation of H3K27, a histone modification associated with transcriptional repression and developmental regulation. As several PRC2 components are upregulated or mutated in a variety of human cancers, efforts to discover small-molecule modulators of PRC2 and understand its regulation may yield therapeutic insights. Identification of small-molecule probes with distinc

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8

Hamzah, Nurasyikin Binti. "Identification and optimisation of small molecule modulators of Orai3 and TRPC4 as potential therapeutics." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/21990/.

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Ca2+ signalling pathways require different types of ion channels to help control the concentration of Ca2+ in the cell in order to carry out diverse physiological activities. Excessive Ca2+ leads to therapeutic diseases such as necrosis,[1] cancer,[2] and heart failure.[3] Unfortunately, many of the available calcium inhibitors suffer from weak potency and selectivity profiles (i.e TRP, sodium, potassium channels). Two Ca2+ ion proteins (Orai3 and TRPC4) were selected to target with novel chemical probes to better understand their biological function and potential utility as therapeutic target

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9

Mota, F. "The discovery of small molecule modulators of soluble guanylate cyclase aided by surface plasmon resonance." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1434127/.

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Soluble guanylate cyclase is a multidimeric enzyme that regulates cardiovascular homeostasis and is the receptor for nitric oxide in the brain. The enzyme is the known target for a new agonist drug used for the treatment of pulmonary hypertension. Whilst drug discovery has been successful for the finding of small molecules that activate the enzyme, the currently available inhibitors lack selectivity as they act through oxidation of a heme prosthetic group in the enzyme, which is conserved amongst other hemeproteins. Nonetheless, it has been suggested that inhibition of soluble guanylate cyclas

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10

Ang, Jit Hang Jackie. "Developing biophysical and structural methods for characterisation of small molecule modulators of K2P potassium channels." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:850d137b-6270-48d9-9eaa-ce6fb65dcbc4.

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Biophysical techniques are widely used to determine the structure, function and ligand binding properties of a protein. However, their application to membrane proteins has been limited due to the difficulty of obtaining sufficient purified sample. In this work, I use such methods to examine the thermostability and ligand binding properties of TREKs, two members of the family of tandem pore domain K<sup>+</sup> channels important for the regulation of cellular excitability. Structures of TREK1 and TREK2 are available and thus when combined with such approaches may help guide the design of bette

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11

Mahasenan, Kiran V. "Discovery of novel small molecule enzyme inhibitors and receptor modulators through structure-based computational design." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1332367560.

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12

Elhusseini, M. A. E. "The design and sythesis of small molecule modulators of the arylhydrocarbon receptor and NRF2 transcription factors." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1559055/.

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Carcinogenesis is a complex process which requires a number of modifications to the genome in order to progress to tumor formation. Reactive oxygen species (ROS) have been identified as one of the causes of these mutations. The cellular response to ROS is to upregulate the production of an array of detoxifying enzymes. The transcription factors Nrf2 (nuclear factor erythroid 2-p45 related factor 2) and the AhR (arylhydrocarbon receptor) are modulators of antioxidant response element and xenobiotic response element regulated genes respectively. These proteins control biological responses to a r

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13

Setiawan, Careza [Verfasser], and Moritz [Akademischer Betreuer] Rossner. "NRG1 cleavage assay and small molecule screen for modulators of NRG1 processing / Careza Setiawan ; Betreuer: Moritz Rossner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1168145848/34.

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14

Selvadurai, Jayashankar [Verfasser]. "A combinatorial approach to study structure-activity relationships of myosins and dynamins using small molecule modulators / Jayashankar Selvadurai." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2012. http://d-nb.info/1024918939/34.

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15

Ursu, Andrei [Verfasser], Herbert [Akademischer Betreuer] Waldmann, and Hans Robert [Gutachter] Schöler. "Development of small molecule modulators of stem cell reprogramming / Andrei Ursu. Betreuer: Herbert Waldmann. Gutachter: Hans Robert Schöler." Dortmund : Universitätsbibliothek Dortmund, 2015. http://d-nb.info/1110893663/34.

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16

Farrington, Caroline Cain. "TARGETED DEGRADATION OF THE MYC ONCOGENE USING PP2AB56ALPHASELECTIVE SMALL MOLECULE MODULATORS OF PROTEINPHOSPHATASE 2A AS A THERAPEUTIC STRATEGY FOR TREATING MYCDRIVENCANCERS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1579905487094187.

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17

Becker, Ben Verfasser], Adam [Akademischer Betreuer] Antebi, Thorsten [Akademischer Betreuer] Hoppe, and Mats [Akademischer Betreuer] [Paulsson. "Small Molecule Modulators of Dauer Formation and Longevity in Caenorhabditis Elegans / Ben Becker. Gutachter: Adam Antebi ; Thorsten Hoppe ; Mats Paulsson." Köln : Universitäts- und Stadtbibliothek Köln, 2014. http://d-nb.info/1055038655/34.

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Becker, Ben [Verfasser], Adam Akademischer Betreuer] Antebi, Thorsten [Akademischer Betreuer] Hoppe, and Mats [Akademischer Betreuer] [Paulsson. "Small Molecule Modulators of Dauer Formation and Longevity in Caenorhabditis Elegans / Ben Becker. Gutachter: Adam Antebi ; Thorsten Hoppe ; Mats Paulsson." Köln : Universitäts- und Stadtbibliothek Köln, 2014. http://d-nb.info/1055038655/34.

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19

Pedley, Nicholas Michael. "Cell-based phenotypic screens to identify modulators of sensitivity to N-methyl-N'-nitro-N-nitrosoguanidine." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:c5c7fcf3-0a5e-4572-adf7-72e7792ff42d.

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Defective DNA repair capacity has been shown to be a common feature of cancer, and loss of function mutations in 'stability' genes that normally maintain the integrity of the genome may prove a key rate-limiting step in carcinogenesis. Since even genetically unstable cells require some repair functionality to maintain viability, these cancers likely exhibit an over-reliance on other DNA repair pathways for survival. Therapeutically targeting backup repair processes in such tumours represents a novel means by which to achieve selective tumour toxicity. Full exploitation of these synthetic letha

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20

Hinrichs, Wilko [Verfasser], Klaus-Armin [Akademischer Betreuer] Nave, Martin [Akademischer Betreuer] Göpfert, André [Akademischer Betreuer] Fischer, and Moritz [Akademischer Betreuer] Rossner. "A cell-based NRG1-ERBB4 assay designed for high-throughput compound screening to identify small molecule modulators with relevance for schizophrenia / Wilko Hinrichs. Gutachter: Martin Göpfert ; André Fischer ; Moritz Rossner. Betreuer: Klaus-Armin Nave." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1044869100/34.

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21

Barniol, Xicota Marta. "New polycyclic small molecules as ion channel modulators." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/400154.

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L’objectiu de la present tesi doctoral consisteix en desenvolupar molècules policícliques de baix pes molecular que tinguin com a diana tres canals iònics específics: la viroporina A/M2 del virus de la grip, el receptor purinèrgic dependent de lligand P2X7 i el receptor glutamatèrgic dependent de lligand N-metil-D-Aspartat, per tal de modular-los d’una manera tal que n’evitin o millorin el desenvolupament dels processos patogènics associats a aquestes proteïnes i/o que permetin ser emprades com a eines de recerca. En el capítol 1 es presenta una introducció general del paper dels canals iòn

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22

Alwassil, Osama. "Small Molecules as Negative Allosteric Modulators of Alpha7 nAChRs." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2829.

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Alpha7 Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in essential physiological functions and play a role in disorders such as Alzheimer’s disease. MD-354 (3-chlorophenylguanidine; 21), the first small–molecule negative allosteric modulator (NAM) at alpha7 nAChRs, served as a lead in developing structure–activity relationships for NAMs at a7 nAChRs. MD-354 (21) also binds at 5-HT3 receptors. Analogs of MD-354 with structural features detrimental to 5-HT3 receptor affinity were evaluated in patch-clamp recordings and an aniline N-methyl analog resulted in a more potent and se

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23

Riffell, Jenna Louise. "Small molecules as modulators of mitotic arrest and senescence in cancer." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/33801.

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Manipulation of the cell cycle is an extensively used and promising strategy for cancer therapy. To identify novel cell cycle modulators, automated fluorescence microscopy assays were designed and used to screen chemical libraries for modulators of mitotic arrest and senescence. 8-azaguanine, IC 261, erysolin and SKF 96365 were identified as chemicals that stimulate senescence, a state of prolonged growth arrest, in a p53-mutated growth arrest-deficient cell line. Microtubule-targeting cancer therapies such as paclitaxel block cell cycle progression at mitosis by prolonged activation of the mi

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24

Ferroni, Claudia <1980&gt. "Small Molecules as Modulators of Different Targets Involved in Tumor Progression." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4680/.

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Tumor is a lesion that may be formed by an abnormal growth of neoplastic cells. Many factors increase the risk of cancer and different targets are involved in tumor progression. Within this thesis, we have addressed two different biological targets, independently connected with tumor formation, e.g. Hsp90 and androgen receptor. The ATP-dependent chaperone Hsp90 is responsible for the conformational maturation and the renaturation of proteins. “Client” proteins are associated with the cancer hallmarks, as cell proliferation and tumor progression. Consequently, Hsp90 has evolved into promising

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25

Obliers, Miriam. "Novel small molecule modulator of the antioxidant response pathway : potential for therapy in inflammatory diseases/cancer." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=231076.

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26

Polaske, Nathan Walter. "STRUCTURAL ANALYSIS AND SYNTHETIC PROGRESS TOWARDS SMALL MOLECULES AS MODULATORS OF ANGIOGENESIS AT THE CELLULAR AND TRANSCRIPTIONAL LEVELS." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/194357.

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Progress towards the design and the application of small molecules as inhibitors of angiogenesis is reported. First, the regulation of hypoxia inducible transcription with epipolythiodioxopiperazine (ETP) natural products is discussed, beginning with the exploration of the physical and chemical properties of ETP skeletal analogs, xylylene-linked bis-diketopiperazines (1,4-piperazine-2,5-diones, DKPs).The design, synthesis and solid-state structures of a new class of xylylene-linked bis(1,4-piperazine-2,5-diones) are reported in an effort to extend the molecular framework of piperazine-2,5-dio

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27

Chen, Andrew Ph D. Massachusetts Institute of Technology. "Discovery and characterization of a small molecule that modulates c-Myc mediated transcription via max homodimer stabilization." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/123060.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 190-200).<br>The transcription factor Myc is a basic helix-loop-helix leucine zipper (bHLHLZ) protein with crucial roles in regulating normal cellular processes, but its transcriptional activity is deregulated in a majority of human cancers. Myc transcriptional activity is dependent on dimerization with its obligate partner Max, another bHLHLZ transcription factor. Max also forms homodimers as well as heterodime

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Mohanty, Sindhu Tanaya. "A small molecule modulator of prion protein increases human mesenchymal stem cell lifespan, ex vivo expansion and engraftment to bone marrow in NOD/SCID mice." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/7460/.

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Human mesenchymal stem cells (hMSCs) have been shown to have potential in regenerative approaches in bone and blood. Most protocols rely on their in vitro expansion prior to clinical use. However, several groups including our own have shown that hMSC lose proliferation and differentiation ability with serial passage in culture, limiting their clinical applications. Cellular prion protein (PrP) has been shown to enhance proliferation and promote self-renewal of hematopoietic, mammary gland and neural stem cells. With this work I tested the hypothesis that PrP decreased with cellular ageing of h

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29

Tran, Thi Ngoc Tuyen [Verfasser], Herbert [Akademischer Betreuer] Waldmann, and Martin [Gutachter] Engelhard. "Evaluation of the phage display protocol for target identification of small molecules : Identification and characterization of mitosis modulators / Thi Ngoc Tuyen Tran. Betreuer: Herbert Waldmann. Gutachter: Martin Engelhard." Dortmund : Universitätsbibliothek Dortmund, 2014. http://d-nb.info/1101595531/34.

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30

Letso, Reka Rebecca. "Investigating neurodegenerative diseases with small molecule modulators." Thesis, 2011. https://doi.org/10.7916/D8N01DH0.

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Elucidation of the mechanisms underlying cell death in neurodegenerative diseases has proven difficult, due to the complex and interconnected architecture of the nervous system as well as the often pleiotropic nature of these diseases. Cell culture models of neurodegenerative diseases, although seldom recapitulating all aspects of the disease phenotype, enable investigation of specific aspects of these disease states. Small molecule screening in these cell culture models is a powerful method for identifying novel small molecule modulators of these disease phenotypes. Mechanistic studies of the

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31

Moreira, Sara. "Studying p53 family proteins: search for small molecule modulators." Dissertação, 2013. http://hdl.handle.net/10216/75929.

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Moreira, Sara Gomes. "Studying p53 family proteins: search for small molecule modulators." Dissertação, 2013. https://repositorio-aberto.up.pt/handle/10216/85978.

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33

Ribeiro, Carlos Jorge Azevedo Costa 1980. "Design and synthesis of small molecule modulators of p53." Doctoral thesis, 2015. http://hdl.handle.net/10451/20616.

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Tese de doutoramento, Farmácia (Química Farmacêutica e Terapêutica), Universidade de Lisboa, Faculdade de Farmácia, 2015<br>Among the tumor suppressor genes, p53 is one of the most studied. It is widely regarded as the “guardian of the genome”, playing a pivotal part in the preservation of genomic integrity by regulating cell cycle, apoptosis, DNA repair, senescence and angiogenesis, and consequently has a major role in carcinogenesis. The function played by p53 in tumor suppression is further highlighted by the fact that direct inactivation of this gene occurs in more than 50% of malignancies

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Moreira, Sara Gomes. "Studying p53 family proteins: search for small molecule modulators." Master's thesis, 2013. https://repositorio-aberto.up.pt/handle/10216/85978.

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35

Pasyk, Stanislav. "Insights into the Interactions between CFTR and Small Molecule Modulators." Thesis, 2014. http://hdl.handle.net/1807/44127.

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Cystic Fibrosis (CF) is a life-threatening autosomal recessive disease affecting 1:3600 children born in Canada. CF is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channel. The most common disease causing mutation is a deletion of residue F508, resulting in a structurally compromised protein which is retained in the endoplasmic reticulum and targeted for proteasomal degradation. Therapeutic strategies currently being pursued to alleviate the afflictions caused by this and other mutants include the use of corrector compounds to modify the surfac

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Acúrcio, Rita C. "Discovery and development of new small-molecule immune system modulators." Doctoral thesis, 2019. http://hdl.handle.net/10451/42786.

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Modulation of immune modulatory pathways has emerged as one of the most successful and explored approaches for cancer immunotherapy. Current therapeutics include monoclonal antibodies, which have shown impressive clinical outcomes in the treatment of several types of tumors. However, low response rate, patient acquired resistance and induction of severe immune-related adverse effects represent critical drawbacks. To overcome these limitations, complementary strategies that inhibit tumor immunosuppressive pathways and enhance immunity are urgently needed. We hypothesized that inhibition of PD-1

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Mustaly, Hatim Mustafa. "Identification of small molecule modulators of the Hippo tumor suppressor pathway." Thesis, 2015. https://hdl.handle.net/2144/16121.

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The Hippo signaling pathway, originally identified in Drosophila melanogaster and later shown to be conserved in mammals, is essential in regulating organ size and maintaining tissue homeostasis. It is now clear that functional inactivation of the Hippo pathway is common in variety of cancers and promotes their development and progression. This suggests re-activation of Hippo pathway activity may prove an effective anti-cancer therapy. Here, we describe two small molecule activators of the Hippo pathway that we have recently uncovered from a focused small-molecule inhibitor screen.

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Gaines, Theresa D. "DESIGN, SYNTHESIS AND ANALYSIS OF SMALL MOLECULE HETEROCYCLIC AROMATIC-BASED CXCR4 MODULATORS." 2017. http://scholarworks.gsu.edu/chemistry_diss/134.

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CXCR4 is a chemokine receptor that has been linked to several disease related pathways including: HIV-1 proliferation, autoimmune disorders, inflammatory disease and cancer metastasis. The interaction of the C-X-C chemokine receptor type 4 (CXCR4) with C-X-C chemokine ligand 12 (CXCL12) plays a key role in triggering these disease related pathways. Various antagonists for these receptors have been synthesized and tested, but many are not useful clinically either because of toxicity or poor pharmacokinetics. Some of the most extensive CXCR4 antagonist libraries stem from a class of compounds, p

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Leão, Mariana. "Development of yeast-based assays to study p53 family proteins: identification of new small molecule modulators." Tese, 2014. http://hdl.handle.net/10216/77309.

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Leão, Mariana Valencia Castanheira Ferreira. "Development of yeast-based assays to study p53 family proteins: identification of new small molecule modulators." Tese, 2014. https://repositorio-aberto.up.pt/handle/10216/96553.

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Leão, Mariana Valencia Castanheira Ferreira. "Development of yeast-based assays to study p53 family proteins: identification of new small molecule modulators." Doctoral thesis, 2014. https://repositorio-aberto.up.pt/handle/10216/96553.

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MacBride, Megan Marie. "Nuclear receptors as drug targets design and biological evaluation of small molecule modulators of nuclear receptor action /." 2006. http://etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-1216/index.html.

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Costa, Verónica Sofia Leite Salazar e. "Searching for New Potential Small-Molecule Modulators of Pro-Apoptotic Proteins Using the Yeast-Based Screening Assay." Dissertação, 2015. http://hdl.handle.net/10216/80207.

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Costa, Verónica Sofia Leite Salazar e. "Searching for New Potential Small-Molecule Modulators of Pro-Apoptotic Proteins Using the Yeast-Based Screening Assay." Master's thesis, 2015. https://repositorio-aberto.up.pt/handle/10216/84495.

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Ribeiro, Rodrigo Filipe Nunes. "Small Molecule Modulators of the Circadian Rhythm: From Identification & Development to Pharmacological Potentials in Clock-related Disorders." Master's thesis, 2019. http://hdl.handle.net/10316/88258.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>This dissertation contains both internship reports – community pharmacy internship at Farmácia Machado and pharmaceutical industry internship at Bluepharma's Medical Affairs sector - in the form of a SWOT analysis and the monograph entitle "Small Molecule Modulators of the Circadian Rhythm: From Identification & Development to Pharmacological Potentials in Clock-related Disorders".The circadian clocks are internal timers hierarchically organized and composed of transcription-translationa

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YuWu, Szu, and 吳思宇. "Screening for small-molecule modulators for leukocyte reactive oxygen species production as drugs for diseases caused by redox immune dysregulation." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/3qn53j.

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47

Hinrichs, Wilko. "A cell-based NRG1-ERBB4 assay designed for high-throughput compound screening to identify small molecule modulators with relevance for schizophrenia." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-EF8B-7.

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48

Block, Peter [Verfasser]. "Concepts to interfere with protein-protein complex formations : data analysis, structural evidence and strategies for finding small molecule modulators / vorgelegt von Peter Block." 2005. http://d-nb.info/97790377X/34.

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Cheung, Sheldon Ting Fong. "Discovery and Development of Small-Molecule Modulators for the Sulfation of Glycosaminoglycans and Studying the Role of O-GlcNAc on CREB through Semisynthesis." Thesis, 2017. https://thesis.library.caltech.edu/9930/13/Thesis_Cheung5.pdf.

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<p>Glycosaminoglycans (GAGs) are sulfated polysaccharides that play key roles in many cellular processes, ranging from viral invasion and cancer metastasis to neuronal development. Their diverse biological activities stem from their complex sulfation patterns, which are tightly regulated in vivo. For instance, the GAG chondroitin sulfate (CS) has been shown to undergo regiochemical sulfation during development and after spinal cord injury. However, few tools exist to modulate specific GAG sulfation patterns and study their importance in different biological contexts. Here, we identified the fi

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O'Neill, Jennifer Campbell. "Syntheses of dipeptidic small molecules and their evaluation as bacterial modulators." 2008. http://www.library.wisc.edu/databases/connect/dissertations.html.

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