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Journal articles on the topic 'SMLC'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Prieto Castillo, Carolina. "Discurso de clausura. XXV Congreso ALAPAC/ML, III Congreso SMLC Chile, XVII Jornada SMLC, Chile 2021." Revista Mexicana de Patología Clínica y Medicina de Laboratorio 67, no. 4 (2020): 173–75. http://dx.doi.org/10.35366/99462.

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Marx, M., P. Vacha, B. Riis, T. Feyerabend, and E. Richter. "444First practical experience with a simulation-multileafcollimator (SMLC)." Radiotherapy and Oncology 40 (January 1996): S114. http://dx.doi.org/10.1016/s0167-8140(96)80453-1.

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3

Kayacan, Erkan. "Sliding mode learning control of uncertain nonlinear systems with Lyapunov stability analysis." Transactions of the Institute of Measurement and Control 41, no. 6 (August 13, 2018): 1750–60. http://dx.doi.org/10.1177/0142331218788125.

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This paper addresses the Sliding Mode Learning Control (SMLC) of uncertain nonlinear systems with Lyapunov stability analysis. In the control scheme, a conventional control term is used to provide the system stability in compact space while a type-2 neuro-fuzzy controller (T2NFC) learns system behaviour so that the T2NFC completely takes over overall control of the system in a very short time period. The stability of the sliding mode learning algorithm has been proven in the literature; however, it is restrictive for systems without overall system stability. To address this shortcoming, a nove

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Nuha, Hilal H., Nachwan M. Andriansyah, and Asep Mulyana. "Simulasi Penentuan Lokasi Perangkat Bergerak dengan Metode Enhanced Observed Time Difference." Jurnal Eksplora Informatika 9, no. 2 (March 31, 2020): 111–23. http://dx.doi.org/10.30864/eksplora.v9i2.306.

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Sebagai alternatif Global Positioning System (GPS) yang berbasis satelit, jaringan seluler yang tersebar di berbagai daerah bisa digunakan untuk penentuan lokasi seperti Enhanced Observed Time Difference (EOTD) yang merupakah teknik penentuan lokasi menggunakan perangkat seluler seperti Base Transceiver Station (BTS) dan Mobile Station (MS). Sistem EOTD membutuhkan komponen tambahan BTS berupa Location Measurement Unit (LMU) dan Serving Mobile Location Center (SMLC). LMU berfungsi memberitahu MS tentang waktu pengiriman sinyal sedangkan SMLC berfungsi sebagai server yang menerima request dari

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Marx, M., P. Vacha, B. Riis, T. Feyerabend, and E. Richter. "413Clinical use of a new simulation-multileaf-collimator (SMLC) in cervical cancer." Radiotherapy and Oncology 40 (January 1996): S106. http://dx.doi.org/10.1016/s0167-8140(96)80422-1.

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6

Shaikh, Mubin, Jay Burmeister, Michael Joiner, Shalini Pandya, Bo Zhao, and Qiang Liu. "Biological effect of different IMRT delivery techniques: SMLC, DMLC, and helical tomotherapy." Medical Physics 37, no. 2 (January 25, 2010): 762–70. http://dx.doi.org/10.1118/1.3284369.

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Orozco Rodríguez, Rafael, and Róger Muñoz Hernández. "Efecto de abonos orgánicos en las propiedades químicas del suelo y el rendimiento de la mora (Rubus adenotrichus) en dos zonas agroecológicas de Costa Rica." Revista Tecnología en Marcha 25, no. 1 (May 21, 2012): 16. http://dx.doi.org/10.18845/tm.v25i1.173.

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<p>El objetivo de esta investigación es evaluar el efecto de dos abonos orgánicos en las propiedades quími- cas del suelo y el rendimiento de plantas de mora (<em>Rubus adenotrichus </em>cv.’Vino’) en dos zonas de Costa Rica.</p> <p>Para ello se establecieron dos experimentos, uno en Buena Vista de Pérez Zeledón (BVPZ) y otro en San Mar tín de León Cor tés (SMLC), ambos en la provin- cia de San José, Costa Rica. La investigación se realizó entre agosto del 2005 y julio del 2008.</p> <p>Se evaluaron tres tratamientos en cada experimen- to: Compost (C) y

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8

FURUE, HIROKAZU, ISA NISHIYAMA, JUN YAMAMOTO, HIROSHI YOKOYAMA, and JUN HATANO. "Molecular Alignment in SmLC Cells Having a Surface Layer with INS Phase Sequence." Ferroelectrics 310, no. 1 (January 2004): 31–35. http://dx.doi.org/10.1080/00150190490510258.

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9

Liu, Qiang, Patrick McDermott, and Jay Burmeister. "Effect of respiratory motion on the delivery of breast radiotherapy using SMLC intensity modulation." Medical Physics 34, no. 1 (December 26, 2006): 347–51. http://dx.doi.org/10.1118/1.2405323.

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Neethu, B., and M. M. Ghangrekar. "Electricity generation through a photo sediment microbial fuel cell using algae at the cathode." Water Science and Technology 76, no. 12 (September 11, 2017): 3269–77. http://dx.doi.org/10.2166/wst.2017.485.

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Abstract Sediment microbial fuel cells (SMFCs) are bio-electrochemical devices generating electricity from redox gradients occurring across the sediment–water interface. Sediment microbial carbon-capture cell (SMCC), a modified SMFC, uses algae grown in the overlying water of sediment and is considered as a promising system for power generation along with algal cultivation. In this study, the performance of SMCC and SMFC was evaluated in terms of power generation, dissolved oxygen variations, sediment organic matter removal and algal growth. SMCC gave a maximum power density of 22.19 mW/m2, wh

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11

Price, Robert A., Scott Murphy, Shawn W. McNeeley, C. M. Charlie Ma, Eric Horwitz, Benjamin Movsas, Adam Raben, and Alan Pollack. "A method for increased dose conformity and segment reduction for SMLC delivered IMRT treatment of the prostate." International Journal of Radiation Oncology*Biology*Physics 57, no. 3 (November 2003): 843–52. http://dx.doi.org/10.1016/s0360-3016(03)00711-9.

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12

Shaikh, M., B. Zhao, J. Burmeister, Q. Liu, S. Pandya, and M. Joiner. "SU-FF-T-503: Biological Effect of Different IMRT Delivery Techniques: SMLC, DMLC and Helical TomoTherapy®." Medical Physics 36, no. 6Part17 (June 2009): 2639. http://dx.doi.org/10.1118/1.3182001.

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13

Lee, T., I. Rosen, R. Fields, and K. Hogstrom. "SU-FF-T-122: Comparison of Helical Tomotherapy to SMLC IMRT for Treatment of Parotid Gland Tumors." Medical Physics 34, no. 6Part9 (June 2007): 2429. http://dx.doi.org/10.1118/1.2760780.

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Wiedenman, J. L., I. Rivera-Rivera, D. Vyas, G. Tsika, L. Gao, K. Sheriff-Carter, X. Wang, L. Y. Kwan, and R. W. Tsika. "Beta-MHC and SMLC1 transgene induction in overloaded skeletal muscle of transgenic mice." American Journal of Physiology-Cell Physiology 270, no. 4 (April 1, 1996): C1111—C1121. http://dx.doi.org/10.1152/ajpcell.1996.270.4.c1111.

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The hypertrophic responses of white fast-twitch muscle to mechanical overload has been investigated using transgenic mice. After 7 wk of overload, endogenous beta-myosin heavy chain (MHC) and slow myosin light chain 1 and 2 (SMLC1, SMLC2) protein were increased in the overloaded plantaris (OP) muscle compared with sham-operated control plantaris (CP)muscle. Concurrently, the levels of endogenous beta-MHC, SMLC1, SMLC2, and cardiac/slow troponin C (CTnC) mRNA transcripts were significantly increased in OP muscles, whereas skeletal troponin C (sTnC) mRNA transcript levels decreased. As an initia

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Nalichowski, A., P. McDermott, and J. Burmeister. "TU-FF-A1-03: Comparison of Surface Dose Resulting From SMLC and Compensator-Based IMRT for Breast Radiotherapy." Medical Physics 33, no. 6Part18 (June 2006): 2218. http://dx.doi.org/10.1118/1.2241640.

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Nepomnaschy, Irene, Adriana Déroche, Christiane Dosne Pasqualini, and Isabel Piazzon. "Maternal influence on the immune response: SMLC reactions between identical and reciprocal F1 hybrids and the role of lactation." Immunology Letters 18, no. 1 (May 1988): 19–25. http://dx.doi.org/10.1016/0165-2478(88)90064-8.

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Maylem, Excel Rio, Leon Spicer, Isadora Batalha, and Luis Schutz. "PSIV-5 Developmental and hormonal regulation of gene expression of fibrillin-1 (FBN1) and the asprosin receptor, olfactory receptor family 4 subfamily M member 1 (OR4M1), in bovine ovarian cells." Journal of Animal Science 98, Supplement_4 (November 3, 2020): 283–84. http://dx.doi.org/10.1093/jas/skaa278.510.

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Abstract Asprosin is a novel fasting-induced protein associated with insulin resistance and polycystic ovaries in humans. It is encoded by FBN1 gene and produced when FBN1 is cleaved by the enzyme furin. In cattle, the role of asprosin is unknown. To characterize mRNA abundance of FBN1, furin, and the asprosin receptor, OR4M1, in granulosa (GC) and theca cells (TC), and identify hormones regulating FBN1 mRNA expression, GC and TC from small (&lt; 6 mm; SM) and large (&gt;5 mm; LG) follicles were collected from heifers at an abattoir and used for real-time gene expression analysis or in

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18

Zhu, X. Ronald, Christopher J. Schultz, and Michael T. Gillin. "Planning quality and delivery efficiency of sMLC delivered IMRT treatment of oropharyngeal cancers evaluated by RTOG H-0022 dosimetric criteria." Journal of Applied Clinical Medical Physics 5, no. 4 (October 1, 2004): 80–95. http://dx.doi.org/10.1120/jacmp.2022.25307.

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Zhu, X. Ronald, Christopher J. Schultz, and Michael T. Gillin. "Planning quality and delivery efficiency of sMLC delivered IMRT treatment of oropharyngeal cancers evaluated by RTOG H-0022 dosimetric criteria." Journal of Applied Clinical Medical Physics 5, no. 4 (September 2004): 80–95. http://dx.doi.org/10.1120/jacmp.v5i4.2014.

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Burmeister, Jay, Patrick N. McDermott, Todd Bossenberger, Edgar Ben-Josef, Kenneth Levin, and Jeffrey D. Forman. "Effect of MLC leaf width on the planning and delivery of SMLC IMRT using the CORVUS inverse treatment planning system." Medical Physics 31, no. 12 (November 10, 2004): 3187–93. http://dx.doi.org/10.1118/1.1812607.

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Price, R. A., K. Paskalev, S. McNeeley, and C.-M. Ma. "Elongated beamlets: a simple technique for segment and MU reduction for sMLC IMRT delivery on accelerators utilizing 5 mm leaf widths." Physics in Medicine and Biology 50, no. 19 (September 21, 2005): N235—N242. http://dx.doi.org/10.1088/0031-9155/50/19/n01.

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Tyagi, N., J. Moran, D. Litzenberg, B. Fraass, and I. Chetty. "TU-C-T-6E-07: Monte Carlo Investigation of Dosimetric Differences Between SMLC and DMLC IMRT Delivery Techniques in Heterogeneous Media." Medical Physics 32, no. 6Part16 (May 26, 2005): 2090. http://dx.doi.org/10.1118/1.1998375.

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Liu, Q., P. McDermott, and J. Burmeister. "TU-EE-A2-02: Effect of Respiratory Motion On the Delivery of Breast Radiotherapy Using Physical Compensators and SMLC Intensity Modulation." Medical Physics 32, no. 6Part17 (May 26, 2005): 2108–9. http://dx.doi.org/10.1118/1.1998449.

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Maylem, Excel Rio S., Leon J. Spicer, Isadora Batalha, and Luis F. Schutz. "Discovery of a possible role of asprosin in ovarian follicular function." Journal of Molecular Endocrinology 66, no. 1 (January 2021): 35–44. http://dx.doi.org/10.1530/jme-20-0218.

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Asprosin is a novel fasting-induced protein encoded by fibrillin-1 (FBN1) gene, produced when FBN1 is cleaved by the enzyme furin, and is associated with insulin resistance and polycystic ovarian syndrome in humans. To characterize mRNA abundance of FBN1, FURIN, and the presumed asprosin receptor, olfactory receptor family 4 subfamily M member 1 (OR4M1) in granulosa (GC) and theca cells (TC), and identify hormones regulating FBN1 mRNA expression, GC and TC from small (1–5 mm; SM) and large (>8 mm; LG) follicles were collected from ovaries of heifers obtained at an abattoir and used for real

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Liu, Lixin, Meijie Qi, Yujie Liu, Xinzhu Xue, Danni Chen, and Junle Qu. "Super-Resolution Image Reconstruction Based on Single-Molecule Localization Algorithm." Photonics 8, no. 7 (July 12, 2021): 273. http://dx.doi.org/10.3390/photonics8070273.

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Fluorescence imaging is an important and efficient tool in cell biology and biomedical research. In order to observe the dynamics of biological macromolecules such as DNA, RNA and proteins in live cells, it is extremely necessary to surpass the Abbe diffraction limit in microscopic imaging. Single-molecule localization microscopy (SMLM) is a sort of super-resolution imaging technique that can obtain a large number of images of sparse fluorescent molecules by the use of photoswitchable fluorescent probes and single-molecule localization technology. The center positions of fluorescent molecules

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de Vasconcelos, Suyane Maria Luna Cruz, Mary Anne Sampaio de Melo, Joao Paulo Marques Saraiva Wenceslau, Iriana Carla Junqueira Zanin, Haroldo Cesar Pinheiro Beltrao, Carlos Augusto Oliveira Fernandes, Paulo Cesar de Almeida, and Lidiany Karla Azevedo Rodrigues. "In situ Assessment of Effects of the Bromide- and Fluoride-incorporating Adhesive Systems on Biofilm and Secondary Caries." Journal of Contemporary Dental Practice 15, no. 2 (2014): 142–48. http://dx.doi.org/10.5005/jp-journals-10024-1504.

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ABSTRACT Aim This in situ study assessed the effects of adhesive systems containing or not fluoride and/or the antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) on the microbiological composition of dental biofilm and enamel demineralization. Materials and methods During two phases of 14 days, ten volunteers wore intraoral palatal appliances containing two slabs of human enamel according to a double-blind, crossover design. The slabs were randomly restored using a composite resin and one of the following adhesive systems: All-Bond SETM (self-etch, fluoride/MDPB free adhe

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Tyagi, N., D. Litzenberg, J. Moran, B. Fraass, and I. Chetty. "SU-FF-T-445: Use of the Monte Carlo Method as a Comprehensive Tool for SMLC and DMLC-Based IMRT Delivery and Quality Assurance (QA)." Medical Physics 33, no. 6Part13 (June 2006): 2148. http://dx.doi.org/10.1118/1.2241364.

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Kira, T., H. Awano, S. Shuto, A. Matsuda, M. Baba, K. Konno, and S. Shigeta. "The FIAU Derivative (2′S)-2′-Deoxy-2′-C-Methyl-5-Iodouridine (SMIU) is a Novel, Less Cytotoxic and Potent anti-HSV and anti-VZV Agent." Antiviral Chemistry and Chemotherapy 7, no. 4 (August 1996): 209–12. http://dx.doi.org/10.1177/095632029600700406.

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In this study, the anti-herpetic activities of novel 2′-methyl nucleoside analogues which were substituted at the 5 position of the pyrimidine with a halogen were investigated. The 2′-fluoro-5-iodo-aracytosine (FIAC) congeners (2′S)-2′-deoxy-2′- C-methylcytidine which were substituted with Br or I at the 5 position (SMBC or SMIC); and 2′-fluoro-5-iodo-arauridine (FIAU) congeners (2′S)-2′-deoxy-2′-C-methyluridine which were substituted with Br or I at the 5 position (SMBU or SMIU), proved to have potent antiviral activities against herpes simplex virus type-1 (HSV-1) and varicella-zoster virus

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Nichols, Jacqueline A., Maria Chiara Perego, Luis F. Schütz, Amber M. Hemple, and Leon J. Spicer. "Hormonal regulation of vascular endothelial growth factor A (VEGFA) gene expression in granulosa and theca cells of cattle1." Journal of Animal Science 97, no. 7 (May 11, 2019): 3034–45. http://dx.doi.org/10.1093/jas/skz164.

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Abstract Vascular endothelial growth factor A (VEGFA) stimulates angiogenesis and is associated with increased vascularity in ovarian follicles of cattle. The objectives of this study were to investigate the developmental and hormonal regulation of VEGFA expression in ovarian granulosa and theca cells (TC) of cattle. Bovine ovaries were collected from a local slaughterhouse and granulosa cells (GC) and TC were collected from small (SM; 1 to 5 mm) and large (LG; 8 to 20 mm) follicles. Cells were collected fresh or cultured in serum-free medium and treated with various factors that regulate angi

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Mizutani, Yoichi, Hiroyuki Nakanishi, Kosuke Yamamoto, Yong Nan Li, Hiroki Matsubara, Kazuya Mikami, Koji Okihara, Akihiro Kawauchi, Benjamin Bonavida, and Tsuneharu Miki. "Downregulation of Smac/DIABLO Expression in Renal Cell Carcinoma and Its Prognostic Significance." Journal of Clinical Oncology 23, no. 3 (January 20, 2005): 448–54. http://dx.doi.org/10.1200/jco.2005.02.191.

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Purpose Second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) was recently identified as a protein that is released from mitochondria in response to apoptotic stimuli and promotes apoptosis by antagonizing inhibitor of apoptosis proteins. Furthermore, Smac/DIABLO plays an important regulatory role in the sensitization of cancer cells to both immune- and drug-induced apoptosis. However, little is known about the clinical significance of Smac/DIABLO in various cancers, including renal cell carcinoma (RCC). This study examined Sma

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Liu, Peijun, Jining Lu, Wellington V. Cardoso, and Cyrus Vaziri. "The SPARC-related Factor SMOC-2 Promotes Growth Factor-induced Cyclin D1 Expression and DNA Synthesis via Integrin-linked Kinase." Molecular Biology of the Cell 19, no. 1 (January 2008): 248–61. http://dx.doi.org/10.1091/mbc.e07-05-0510.

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Secreted modular calcium-binding protein-2 (SMOC-2) is a recently-identified SPARC-related protein of unknown function. In mRNA profiling experiments we, found that SMOC-2 expression was elevated in quiescent (G0) mouse fibroblasts and repressed after mitogenic stimulation with serum. The G0-specific expression of SMOC-2 was similar to that of platelet-derived growth factor-β receptor (PDGFβR), a major mitogenic receptor. Therefore, we tested a possible role for SMOC-2 in growth factor-induced cell cycle progression. SMOC-2 overexpression augmented DNA synthesis induced by serum and fibroblast

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Mizutani, Yoichi, and Haruhito Azuma. "Prognostic significance of second mitochondria-derived activator of caspase expression in bladder cancer and target for therapy." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): e15000-e15000. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e15000.

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e15000 Background: Although the expression of second mitochondria-derived activator of caspase (Smac/DIABLO) has been reported in various cancers, little is known about its clinical significance in bladder cancer. The present study was designed to evaluate the relationship between progression of disease and Smac/DIABLO expression by clinical pathological analysis of patients with bladder cancer. Methods: The level of Smac/DIABLO expression was quantified by western blot analysis using non-fixed fresh frozen tissues derived from patients with bladder cancer. Results: All normal bladders express

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Roberts, Darren L., Wendy Merrison, Marion MacFarlane, and Gerald M. Cohen. "The Inhibitor of Apoptosis Protein-Binding Domain of Smac Is Not Essential for Its Proapoptotic Activity." Journal of Cell Biology 153, no. 1 (April 2, 2001): 221–28. http://dx.doi.org/10.1083/jcb.153.1.221.

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Smac/DIABLO, a recently identified inhibitor of apoptosis protein (IAP)-binding protein, is released from the mitochondria during apoptosis and reportedly potentiates apoptosis by relieving the inhibition of IAPs on caspases. We now describe the molecular characterization of Smac β, an alternatively spliced form of Smac, which lacks the mitochondrial-targeting sequence found in Smac and has a cortical distribution in both human embryonic kidney 293 and breast epithelial tumor MCF-7 cells. Smac β, which binds IAPs in vitro, does not bind IAPs in intact cells due to cellular processing and remov

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Okada, Hitoshi, Woong-Kyung Suh, Jianping Jin, Minna Woo, Chunying Du, Andrew Elia, Gordon S. Duncan, et al. "Generation and Characterization of Smac/DIABLO-Deficient Mice." Molecular and Cellular Biology 22, no. 10 (May 15, 2002): 3509–17. http://dx.doi.org/10.1128/mcb.22.10.3509-3517.2002.

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ABSTRACT The mitochondrial proapoptotic protein Smac/DIABLO has recently been shown to potentiate apoptosis by counteracting the antiapoptotic function of the inhibitor of apoptosis proteins (IAPs). In response to apoptotic stimuli, Smac is released into the cytosol and promotes caspase activation by binding to IAPs, thereby blocking their function. These observations have suggested that Smac is a new regulator of apoptosis. To better understand the physiological function of Smac in normal cells, we generated Smac-deficient (Smac−/− ) mice by using homologous recombination in embryonic stem (E

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Koohang, Alex, Joanna Paliszkiewicz, and Jerzy Goluchowski. "Social media privacy concerns: trusting beliefs and risk beliefs." Industrial Management & Data Systems 118, no. 6 (July 9, 2018): 1209–28. http://dx.doi.org/10.1108/imds-12-2017-0558.

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Purpose The purpose of this paper is to build a research model that examines social media privacy concerns (SMPC) in relation to users’ trusting beliefs and risk beliefs. Design/methodology/approach An instrument with eight constructs (SMPC: collection, SMPC: secondary usage, SMPC: errors, SMPC: improper access, SMPC: control, SMPC: awareness, trusting beliefs and risk beliefs) was developed and administered to subjects from a mid-sized university in the USA. Collected data were analyzed using partial least square structural equation modeling. Findings The results showed that three of the six

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Giagkousiklidis, Stavros, Hubert Kasperczyk, Meike Vogler, Klaus-Michael Debatin та Simone Fulda. "Sensitization for γ-Irradiation-Induced Apoptosis by Smac." Blood 104, № 11 (16 листопада 2004): 3392. http://dx.doi.org/10.1182/blood.v104.11.3392.3392.

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Abstract Smac is released from mitochondria during the onset of apoptosis and promotes apoptosis via abrogating the binding of Inhibitor of Apoptosis Proteins (IAPs) to caspases. γ-irradiation is one of the most commonly used therapeutic approaches in clinical oncology, which triggers cell death in tumors via DNA and/or membrane damage. Since we recently found that Smac agonists sensitized even resistant tumors for apoptosis induced by death receptor ligation or anticancer drugs, we investigated the effect of Smac agonists on apoptosis following γ-irradiation in the present study. Here, we rep

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Ali, Rafat, Shalini Singh, and Wahajul Haq. "IAP Proteins Antagonist: An Introduction and Chemistry of Smac Mimetics under Clinical Development." Current Medicinal Chemistry 25, no. 31 (October 16, 2018): 3768–95. http://dx.doi.org/10.2174/0929867325666180313112229.

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Background: Smac mimetics (also known as IAP antagonist) are a new class of targeted drugs having a goal to suppress the IAPs, reestablishing the apoptotic pathways and inducing cancer cell death. Therefore, development of Smac mimetics was considered an attractive strategy for the development of new anticancer drugs. Lots of reviews have come in yesteryears which mainly discussed the biology of IAPs and their role in cancer development. None of these reviews focused on the chemical synthesis of Smac mimetics. Methods: Literature study was done by using standard bibliographic search engines li

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Brock, D. A., G. Buczynski, T. P. Spann, S. A. Wood, J. Cardelli, and R. H. Gomer. "A Dictystelium mutant with defective aggregate size determination." Development 122, no. 9 (September 1, 1996): 2569–78. http://dx.doi.org/10.1242/dev.122.9.2569.

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Starved Dictyostelium cells aggregate into groups of roughly 10(5) cells. We have identified a gene which, when repressed by antisense transformation or homologous recombination, causes starved cells to form large numbers of small aggregates. We call the gene smlA for small aggregates. A roughly 1.0 kb smlA mRNA is expressed in vegetative and early developing cells, and the mRNA level then decreases at about 10 hours of development. The sequence of the cDNA and the derived amino acid sequence of the SmlA protein show no significant similarity to any known sequence. There are no obvious motifs

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Stefansson, Gunnar, and Jamie Lentin. "From Smileys to Smileycoins: Using a Cryptocurrency in Education." Ledger 2 (December 18, 2017): 38–54. http://dx.doi.org/10.5195/ledger.2017.103.

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This paper describes a cryptocurrency to reward students for their studies. The currency bears the apt name Smileycoin or SMLY and is used within the tutor-web online learning platform. In order to make the SMLY attractive to students several approaches have been used, including support from companies whose services can be purchased for SMLY. The paper describes the use of the SMLY as a reward mechanism in a large undergraduate calculus course, including student adoption, student use of SMLY, coinbase use for education in low-income areas, and response to abuse.

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Gaylord, Graham, S. Kathleen Bailey, and John M. Haggarty. "Introducing Shared Mental Health Care in Northwestern Ontario: An Analysis of Changing Referral Patterns of Primary Care Providers." Canadian Journal of Community Mental Health 34, no. 2 (July 1, 2015): 63–72. http://dx.doi.org/10.7870/cjcmh-2015-020.

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This study describes a shared mental health care (SMHC) model introduced in Northern Ontario and examines how its introduction affected primary care provider (PCP) mental health referral patterns. A chart review examined referrals (N = 4,600) from 5 PCP sites to 5 outpatient community mental health services from January 2001 to December 2005. PCPs with access to SMHC made significantly more mental health referrals (p < 0.001). Two demographically similar PCPs were then compared, one co-located with SMHC. Referrals for depression to non-SMHC mental health services were 1.69 times more likely

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Chang, Yung-Chieh, and Chun Hei Antonio Cheung. "An Updated Review of Smac Mimetics, LCL161, Birinapant, and GDC-0152 in Cancer Treatment." Applied Sciences 11, no. 1 (December 31, 2020): 335. http://dx.doi.org/10.3390/app11010335.

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Inhibitor of apoptosis proteins (IAPs) are suggested as therapeutic targets for cancer treatment. Smac/DIABLO is a natural IAP antagonist in cells; therefore, Smac mimetics have been developed for cancer treatment in the past decade. In this article, we review the anti-cancer potency and novel molecular targets of LCL161, birinapant, and GDC-0152. Preclinical studies demonstrated that Smac mimetics not only induce apoptosis but also arrest cell cycle, induce necroptosis, and induce immune storm in vitro and in vivo. The safety and tolerance of Smac mimetics are evaluated in phase 1 and phase 2

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Zhao, Xiaolan, Bilyana Georgieva, Andrei Chabes, Vladimir Domkin, Johannes H. Ippel, Jürgen Schleucher, Sybren Wijmenga, Lars Thelander, and Rodney Rothstein. "Mutational and Structural Analyses of the Ribonucleotide Reductase Inhibitor Sml1 Define Its Rnr1 Interaction Domain Whose Inactivation Allows Suppression of mec1 andrad53 Lethality." Molecular and Cellular Biology 20, no. 23 (December 1, 2000): 9076–83. http://dx.doi.org/10.1128/mcb.20.23.9076-9083.2000.

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ABSTRACT In budding yeast, MEC1 and RAD53 are essential for cell growth. Previously we reported that mec1or rad53 lethality is suppressed by removal of Sml1, a protein that binds to the large subunit of ribonucleotide reductase (Rnr1) and inhibits RNR activity. To understand further the relationship between this suppression and the Sml1-Rnr1 interaction, we randomly mutagenized the SML1 open reading frame. Seven mutations were identified that did not affect protein expression levels but relieved mec1 and rad53inviability. Interestingly, all seven mutations abolish the Sml1 interaction with Rnr

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Espinosa, Magali, Floria Lizárraga, Karla Vázquez-Santillán, Alfredo Hidalgo-Miranda, Patricia Piña-Sánchez, Javier Torres, Román A. García-Ramírez, Vilma Maldonado, Jorge Melendez-Zajgla, and Gisela Ceballos-Cancino. "Coexpression of Smac/DIABLO and Estrogen Receptor in breast cancer." Cancer Biomarkers 30, no. 4 (April 9, 2021): 429–46. http://dx.doi.org/10.3233/cbm-200535.

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BACKGROUND: Smac/DIABLO is a proapoptotic protein deregulated in breast cancer, with a controversial role as a tumor marker, possibly due to a lack of correlative mRNA and protein analyses. OBJECTIVE: To investigate the association of Smac/DIABLO gene and protein levels with clinical variables in breast cancer patients. METHODS: Smac/DIABLO mRNA expression was analyzed by qPCR in 57 frozen tissues, whereas protein levels were assessed by immunohistochemistry in 82 paraffin-embedded tissues. Survivin mRNA levels were also measured. In vitro assays were performed to investigate possible regulato

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Chang, Yeonho, Do-Hyeon Kim, Kai Zhou, Min Gyu Jeong, Soyeon Park, Yonghoon Kwon, Triet Minh Hong, Jungeun Noh, and Sung Ho Ryu. "Improved resolution in single-molecule localization microscopy using QD-PAINT." Experimental & Molecular Medicine 53, no. 3 (March 2021): 384–92. http://dx.doi.org/10.1038/s12276-021-00572-4.

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AbstractSingle-molecule localization microscopy (SMLM) has allowed the observation of various molecular structures in cells beyond the diffraction limit using organic dyes. In principle, the SMLM resolution depends on the precision of photoswitching fluorophore localization, which is inversely correlated with the square root of the number of photons released from the individual fluorophores. Thus, increasing the photon number by using highly bright fluorophores, such as quantum dots (QDs), can theoretically fundamentally overcome the current resolution limit of SMLM. However, the use of QDs in

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Miao, Wang, Wu Qiuji, Song Congkuan, Liu Yixin, Wang Xulong, Zhang Boyu, Qin Guizhen, Zhang Jun, and Wei Yongchang. "Small cell carcinoma as an independent prognostic factor for cervical cancer patients: a population-based analysis." Future Oncology 17, no. 24 (August 2021): 3175–85. http://dx.doi.org/10.2217/fon-2020-1081.

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Aim: To compare cervical small cell carcinoma (SmCC) with squamous cell carcinoma (SCC) in patient characteristics and survival outcomes. Methods: Cervical SmCC and SCC patients in Surveillance, Epidemiology, and End Results database from 2004 to 2015 were enrolled. Propensity-score matching analysis (PSM) paired subjects with similar background variables. Cox regression, Kaplan–Meier and stratified analyses were conducted before and after PSM. Results: Cervical SmCC patients showed a higher rate of larger tumor size, advanced grade disease, lymph node involvement and distant metastasis (p &lt

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Chaiyakit, Pruk, Ittiwat Onklin, and Weeranate Ampunpong. "Result of posteromedial capsule and superficial medial collateral ligament release on gap and alignment in total knee arthroplasty in varusknee deformity by computer assisted surgery measurement: a retrospective stud." Orthopaedic Journal of Sports Medicine 8, no. 5_suppl5 (May 1, 2020): 2325967120S0006. http://dx.doi.org/10.1177/2325967120s00063.

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Soft tissue release and gap balancing in total knee arthroplasty (TKA) are important issue and lack of conclusive result. We performed posteromedial capsule (PMC) and superficial medial collateral ligament (sMCL) release by preservation of anterior attachment of pes anserine. Gaps and alignment were recorded by computer assisted surgery measurement. Results: T: The mean correction of varus deformity after PMC release and sMCL release were 4.88 ± 2.82° and 3.39 ± 1.7 respectively with the mean FC after PMC and sMCL release correction of 5.57 ± 3.5 and 1.34 ± 2.9° respectively. The mean medial g

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Merriam, Laura A., Fabiana S. Scornik, and Rodney L. Parsons. "Ca2+-Induced Ca2+ Release Activates Spontaneous Miniature Outward Currents (SMOCs) in Parasympathetic Cardiac Neurons." Journal of Neurophysiology 82, no. 2 (August 1, 1999): 540–50. http://dx.doi.org/10.1152/jn.1999.82.2.540.

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Mudpuppy parasympathetic cardiac neurons exhibit spontaneous miniature outward currents (SMOCs) that are thought to be due to the activation of clusters of large conductance Ca2+-activated K+ channels (BK channels) by localized release of Ca2+ from internal stores close to the plasma membrane. Perforated-patch whole cell recordings were used to determine whether Ca2+-induced Ca2+ release (CICR) is involved in SMOC generation. We confirmed that BK channels are involved by showing that SMOCs are inhibited by 100 nM iberiotoxin or 500 μM tetraethylammonium (TEA), but not by 100 nM apamin. SMOC fr

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Guo, Fei, Ramadevi Nimmanapalli, Shanthi Paranawithana, Sylvie Wittman, David Griffin, Purva Bali, Erica O'Bryan, Carlos Fumero, Hong Gang Wang, and Kapil Bhalla. "Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative–(BMS 247550) and Apo-2L/TRAIL–induced apoptosis." Blood 99, no. 9 (May 1, 2002): 3419–26. http://dx.doi.org/10.1182/blood.v99.9.3419.

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Abstract Second mitochondria-derived activator of caspases (Smac)/DIABLO is a mitochondrial protein that is released into the cytosol along with cytochrome c (cyt c) during the execution of the intrinsic pathway of apoptosis. Smac/DIABLO promotes apoptosis by neutralizing the inhibitory effect of the inhibitor of apoptosis (IAP) family of proteins on the processing and activities of the effector caspases. Present studies demonstrate that, upon engagement of the mitochondrial pathway of apoptosis, epothilone (Epo) B derivative BMS 247550, a novel nontaxane antimicrotubule agent, as well as the

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Yin, Tao, Xiao Min Cai, Lin Su, Ling Wang, Fei Rong, Chun Wei Yuan, and De Gang Fu. "Lake Sediment Microbial Fuel Cell Generate Electricity and Power Wireless Sensor." Advanced Materials Research 773 (September 2013): 74–79. http://dx.doi.org/10.4028/www.scientific.net/amr.773.74.

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Sediment microbial fuel cells (SMFCs) can generate electricity without maintenance in the field. SMFC is considered as an alternative renewable and sustainable power source. Though the SMFC is very appealing energy source, it presents certain challenges for real applications. Its output voltage and current are very low and its output voltage cant be increased by stacking several SMFCs in series in an open water body such as the lake. In this research, we construct and simulate a field SMFC with sediment from Xuanwu Lake in Nanjing, China. Open-circuit voltage of the SMFC is 750 mV and the maxi

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Li, Zhen, Michelle Annett, Ken Hinckley, and Daniel Wigdor. "SMAC." Proceedings of the ACM on Human-Computer Interaction 3, EICS (June 13, 2019): 1–47. http://dx.doi.org/10.1145/3300961.

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