Relevant bibliographies by topics / SMRT

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'SMRT'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 March 2023

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Journal articles on the topic "SMRT"

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Poizat, Jean-Claude, and Françoise Dasturová. "Smrt." REFLEXE 2019, no. 57 (February 25, 2020): 143–60. http://dx.doi.org/10.14712/25337637.2020.11.

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Vukčević, Vladan. "Iznenadna srčana smrt." Srce i krvni sudovi 30, no. 4 (2011): 175–76. http://dx.doi.org/10.5937/siks1103175v.

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Ghoshal, Pushpankur, Christiane Houde, Angela Szafranek, Alain Nganga, Timothy Johnson, Ashley Bigelow, Joseph Moran-Guiati, Dominic Smiraglia, Asher Alban Chanan-Khan, and Lionel J. Coignet. "SMRT; Not So Smart in Multiple Myeloma." Blood 110, no. 11 (November 16, 2007): 4137. http://dx.doi.org/10.1182/blood.v110.11.4137.4137.

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Abstract Multiple myeloma (MM), a clonal B-cell malignancy, characterized by accumulation of plasma cells in bone marrow is the second most hematological malignancy in United States. In the BM, the myeloma and stromal cells secrete cytokines, which support the growth and survival of the myeloma cells. We previously showed that JAG2, one of the NOTCH ligand, is over-expressed in MM cells (Blood. 2004 Dec 1;104(12)). We hypothesized that over-expression of JAG2 in myeloma cells induce secretion of IL-6 from the stromal cells and subsequently enhances the proliferation of myeloma cells. JAG2 has been shown to be over-expressed in all cell lines and patient samples studied To identify the mechanism for JAG2 overexpression in MM cells, we assessed the potential modifications of the JAG2 promoter in MM cell lines as well as patient samples (an JAG2 negative controls) by studying both methylation and histone acetylation level of the JAG2 promoter. We show that difference in H4 acetylation level might play a crucial role in JAG2 expression. Acetylation state of histones can be regulated by the recruitment of histone deacetylases (HDACs). HDACs are typically recruited to promoter regions through interaction with nuclear co-repressors such as SMRT. The cell lines and patient samples studied presented significantly reduced levels of SMRT. Therefore, based on these observations we propose a model in which partial down-regulation of SMRT recruits less active HDAC3 (as confirmed by immunoprecipitation). As a result the deactylation process of histones in the JAG2 promoter region has been impaired and the cells lost their regulatory mechanism on transcriptional regulation of JAG2. This provides a mechanistic explanation for JAG2 over-expression in MM and on the direct involvement of the SMRT co-repressor in MM pathogenesis.
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Nikolić, Milica, and Radomir Konstantinović. "Dekartova smrt." World Literature Today 72, no. 3 (1998): 653. http://dx.doi.org/10.2307/40154171.

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Koch, Linda. "SMRT move?" Nature Reviews Genetics 15, no. 3 (February 4, 2014): 146. http://dx.doi.org/10.1038/nrg3678.

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Stanya, Kristopher J., Yu Liu, Anthony R. Means, and Hung-Ying Kao. "Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT." Journal of Cell Biology 183, no. 1 (October 6, 2008): 49–61. http://dx.doi.org/10.1083/jcb.200806172.

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Silencing mediator for retinoic acid and thyroid hormone receptor (SMRT) is a transcriptional corepressor that participates in diverse signaling pathways and human diseases. However, regulation of SMRT stability remains largely unexplored. We show that the peptidyl-prolyl isomerase Pin1 interacts with SMRT both in vitro and in mammalian cells. This interaction requires the WW domain of Pin1 and SMRT phosphorylation. Pin1 regulates SMRT protein stability, thereby affecting SMRT-dependent transcriptional repression. SMRT phosphorylation at multiple sites is required for Pin1 interaction, and these sites can be phosphorylated by Cdk2, which interacts with SMRT. Cdk2-mediated phosphorylation of SMRT is required for Pin1 binding and decreases SMRT stability, whereas mutation of these phosphorylation sites abrogates Pin1 binding and stabilizes SMRT. Finally, decreases in SMRT stability occur in response to the activation of Her2/Neu/ErbB2, and this receptor functions upstream of both Pin1 and Cdk2 in the signaling cascade that regulates SMRT stability and cellular response to tamoxifen.
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Chen, Rui, Hongqian Xue, and Bin Li. "Comparison of SP, SMAT, SMRT, LSP, and UNSM Based on Treatment Effects on the Fatigue Properties of Metals in the HCF and VHCF Regimes." Metals 12, no. 4 (April 10, 2022): 642. http://dx.doi.org/10.3390/met12040642.

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This paper aims to provide a better understanding regarding the effects of shot peening (SP), surface mechanical attrition treatment (SMAT), laser shock peening (LSP), surface mechanical rolling treatment (SMRT), and ultrasonic nanocrystal surface modification (UNSM) on the fatigue properties of metals in high-cycle fatigue (HCF) and very-high-cycle fatigue (VHCF) regimes. The work in this paper finds that SMRT and UNSM generally improve the high-cycle and very-high-cycle fatigue properties of metals, while SP, SMAT, and LSP can have mixed effects. The differences are discussed and analyzed with respect to the aspects of surface finish, microstructure and microhardness, and residual stress. SMRT and UNSM generally produce a smooth surface finish, while SP and SMAT tend to worsen the surface finish on metals, which is harmful to their fatigue properties. In addition to inducing a plastic deformation zone and increasing microhardness, surface treatments can also generate a nanograin layer and gradient microstructure to enhance the fatigue properties of metals. The distribution of treatment-induced residual stress and residual stress relaxation can cause mixed effects on the fatigue properties of metals. Furthermore, increasing residual stress through SP and SMAT can cause further deterioration of the surface finish, which is detrimental to the fatigue properties of metals.
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Vetter, Monica L. "Methylation Gets SMRT." Developmental Cell 5, no. 3 (September 2003): 359–60. http://dx.doi.org/10.1016/s1534-5807(03)00267-3.

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Li, Hui, Christopher Leo, Daniel J. Schroen, and J. Don Chen. "Characterization of Receptor Interaction and Transcriptional Repression by the Corepressor SMRT." Molecular Endocrinology 11, no. 13 (December 1, 1997): 2025–37. http://dx.doi.org/10.1210/mend.11.13.0028.

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Abstract SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) are two related transcriptional corepressors that contain separable domains capable of interacting with unliganded nuclear receptors and repressing basal transcription. To decipher the mechanisms of receptor interaction and transcriptional repression by SMRT/N-CoR, we have characterized protein-protein interacting surfaces between SMRT and nuclear receptors and defined transcriptional repression domains of both SMRT and N-CoR. Deletional analysis reveals two individual nuclear receptor domains necessary for stable association with SMRT and a C-terminal helix essential for corepressor dissociation. Coordinately, two SMRT domains are found to interact independently with the receptors. Functional analysis reveals that SMRT contains two distinct repression domains, and the corresponding regions in N-CoR also repress basal transcription. Both repression domains in SMRT and N-CoR interact weakly with mSin3A, which in turn associates with a histone deacetylase HDAC1 in a mammalian two-hybrid assay. Far-Western analysis demonstrates a direct protein-protein interaction between two N-CoR repression domains with mSin3A. Finally we demonstrate that overexpression of full-length SMRT further represses basal transcription from natural promoters. Together, these results support a role of SMRT/N-CoR in corepression through the utilization of multiple mechanisms for receptor interactions and transcriptional repression.
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Amano, Izuki, Ayane Ninomiya, Megan Ritter, Kristen R. Vella, Anthony Neil Hollenberg, and Noriyuki Koibuchi. "Nuclear Receptor Corepressors NCoR1 and SMRT Plays Unique Roles in Central Nervous System." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A976. http://dx.doi.org/10.1210/jendso/bvab048.1995.

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Abstract The nuclear corepressor 1 (NCoR1) and the silencing mediator of retinoid and thyroid hormone receptors (SMRT) are critical coregulators of the thyroid hormone receptor (TR), mediating transcriptional repression via histone deacetylation. Thyroid hormone (TH) plays an essential role in many physiological processes via the TR. How the corepressors regulate TR signaling is not fully understood, especially in central nervous system (CNS). To determine the role of NCoR1 and SMRT in the CNS, we used mice with conditional NCoR1 (NCoR1lox/lox) and SMRT (SMRTlox/lox) alleles in combination with mice that express Cre recombinase in a neuronal specific fashion (Snap25-Cre). Global deletion of NCoR1 or SMRT during embryogenesis results in lethality. We also showed that NCoR1/SMRT double knock-out mice die within two weeks after induction of Cre activity in adult mice. Now, we found that neuronal specific NCoR1 or SMRT KO mice survive without obvious impairment of neuronal development. However, NCoR1/SMRT double knock-out mice die within postnatal 1-2 weeks and have impaired body growth. Thus, both NCoR1 and SMRT have important roles in maintaining normal neuronal function. Recently, cased of mutations in NCoR1 and SMRT in humans have been reported. These cases report phenotypes including Autism Spectrum Disorder (ASD) and intellectual disability. The cerebellum has been thought to contribute to motor control and learning. Surprisingly, it has also been shown to be a key brain structure involved in social cognition and its dysfunction may play a role in ASD. The Purkinje cell is the main neuron in the cerebellum. Thus, we generated cerebellar Purkinje cell specific NCoR1/SMRT knock-out mice using L7/Pcp2-Cre mice. In contrast to neuronal specific KO mice, both NCoR1 or SMRT single or double knock-out mice survive until adulthood. SMRT Purkinje cell knock-out mice showed abnormalities in 3ch social interaction test indicating impaired social functioning, similar to some ASD symptoms. Electrophysiological testing showed current injection evoked more action potentials in SMRT KO mice. These results suggest Purkinje cell dysfunction caused by SMRT deletion may result in social disability. Our data demonstrate for the first time that NCoR1 and SMRT have separate functions in different areas of the brain but also have some redundant function when knocked out together in all neurons.
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Dissertations / Theses on the topic "SMRT"

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Stanya, Kristopher J. "Phosphorylation-Dependent Regulation of the Corepressor SMRT." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1220559727.

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Kralertová, Jana. "Výstavní cyklus SMRT v objektech Národního muzea." Master's thesis, Vysoká škola ekonomická v Praze, 2015. http://www.nusl.cz/ntk/nusl-264346.

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The thesis focuses on a field of museum marketing, particularly on a marketing mix issue. The marketing mix is described on an example of an exhibition cycle named DEATH which took place in five object of the National museum during a period from 18 June 2014 until 31 March 2016. The DEATH was the last from a row of exhibition cycles which prevailed during the closing of the Historical building for the reason of its complex reconstruction. A descriptive analysis of the marketing mix of the DEATH exhibition cycle is conducted in the thesis. Application of marketing tools is subsequently evaluated through detailed analyses which will identify weaknesses. At the same time recommendations are developed to improve the National museums marketing mix and make it more efficient.
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Nofsinger, Russell R. "Role of corepressor SMRT in nuclear receptor biology /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3148259.

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Kruusvee, Valdeko. "The structural basis of MeCP2 interaction with NCoR/SMRT co-repressor complex." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/25703.

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Rett syndrome (RTT) is an X-linked neurological disorder primarily caused by mutations in the MECP2 gene. The majority of RTT mutations disrupt the interaction of MeCP2 with DNA or TBL1X/TBL1XR1, which forms the scaffold of NCoR/SMRT co-repressor complex. Patients with RTT show no signs of neuronal death, although they have abnormal neuronal morphology, indicating that it is a neurodevelopmental rather than a neurodegenerative disease. It has been shown that reactivation of silenced MeCP2 in mice rescues the RTT phenotype, which implies that the disease is treatable. The RTT mutations in MeCP2 cluster to two regions - the methyl-CpG-binding domain (MBD) and NCoR/SMRT Interaction Domain (NID). While the interaction between MBD and DNA has been biochemically and structurally characterised, there are no structural data about the interaction between MeCP2 NID and TBL1XR1. The aim of this work was to understand how mutations in the NID cause RTT by characterising the interaction between MeCP2 and TBL1XR1. I have solved the structure of MeCP2 NID bound to TBL1XR1 WD40 domain. I show that a small region of the MeCP2 NID makes extensive contacts with TBL1XR1, and that these contacts are mediated primarily by MeCP2 residues known to be mutated in RTT. I also measured the affinities between TBL1XR1 and MeCP2-derived peptides using fluorescence anisotropy and surface plasmon resonance assays. I determined the affinity between MeCP2 NID peptide and TBL1XR1 to be around 10- 20 μM, and show that mutations in either MeCP2 or TBL1XR1 can abolish this interaction. Taken together, these data strongly suggest that the abolition of the interaction between MeCP2 NID and TBL1XR1 WD40 domain is sufficient to cause RTT. This knowledge can help with the rational design of small drug-like molecules that might be able to mediate the interaction between mutated MeCP2 and TBL1XR1, potentially helping to treat the disease.
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Pörzgen, Yvonne. "Entschlossen zur Unentschlossenheit : Meša Selimovićs Roman Derviš i smrt und der Diskurs um die Willensfreiheit." Universität Potsdam, 2011. http://opus.kobv.de/ubp/volltexte/2012/5887/.

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Latreille, Mathieu. "Retinoic acid receptors (RARs) hinge and helix 1 play important roles in the interaction with NCoR and SMRT corepressors." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33796.

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NCoR and SMRT are corepressors that interact with the ligand-binding domain (LBD) of retinoic acid receptors (RARs) in the absence of ligand to repress transcription. This interaction is allowed through the presence of small alpha-helical motifs found in corepressors that interact with residues lining the hydrophobic pocket of the RARs. Unlike RARalpha and RARgamma, RARbeta weakly interacts with NCoR and SMRT. Here we show that the determinants in RARalpha present in helix 1 (H1) (I188), H7 (A311), H9 (D346), and H10 (M377) are important for corepressor binding. Substitution of these amino acids with RARbeta corresponding residues decreased interaction with SMRT. Moreover, gain of function experiments showed that introduction of some of these determinants in RARbeta resulted in an improved ability to interact with SMRT. Furthermore, the hinge region of RARalpha is very important for the stability of the LBD and corepressor binding. In a mammalian two-hybrid assay, we show that in the presence of NCoR, RARbeta hinge region could not stabilize as much its LBD as RARalpha. However, RARalpha hinge efficiently stabilized the LBD of RARbeta in the presence of the corepressor. We also show that the RARbeta H12 inhibits interaction with corepressors. Deletion of H12 rescued these interactions both in solution and on DNA, and rendered RARbeta a potent repressor in vivo. These results suggest that RARbeta, although having a high degree of identity with RARalpha, has major conformational differences that affect its ability to interact with corepressors. All together, these modified receptors will be useful tools to identify determinants in RARs important for corepressor interaction and help elucidate the precise molecular mechanism by which RARbeta acts as a tumor suppressor.
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Piazza, Federica. "sviluppo di metodiche biomolecolari per la cattura e l'eradicazione del gambero rosso della Louisiana Procambarus clarkii (Girard, 1852)." Doctoral thesis, Università degli studi di Trieste, 2015. http://hdl.handle.net/10077/10918.

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2013/2014
L’obiettivo del presente progetto di dottorato consiste nello sviluppo di metodologie innovative per la gestione del Crostaceo Decapode Procambarus clarkii, il gambero rosso della Louisiana. La specie è considerata in gran parte del pianeta come aliena invasiva in quanto è in grado di diffondersi in habitat anche molto diversi da quello d’origine ed è diventata una minaccia per le specie di gamberi locali, con le quali entra in competizione, e provoca danni agli ecosistemi e all’economia. Le vie di introduzione sono gli allevamenti commerciali e la liberazione in natura da parte di acquariofili. La sua diffusione è facilitata dalla notevole capacità di spostamento: P. clarkii riesce a percorrere fino a 3 km in una notte fuori dall’acqua attraverso i campi. In Italia la colonizzazione è stata rapida a causa del degrado degli habitat per la forte antropizzazione e per l’assenza di predatori e di parassiti specifici. Le particolari caratteristiche ecologiche di P. clarkii gli permettono di vivere ovunque, è una specie essenzialmente a strategia r in grado di colonizzare ambienti instabili. Il gambero rosso raggiunge molto rapidamente la maturità sessuale ed è caratterizzato da una riproduzione annuale multipla (fino a 4 volte a seconda della temperatura dell’acqua). L’elevata resistenza agli stress ambientali consente alla specie di vivere in un ampio range di temperature, di sopportare basse concentrazioni di ossigeno, elevata salinità e anche la presenza di inquinanti. Ha abitudini alimentari generaliste, nutrendosi di macroinvertebrati, pesci, anfibi; inoltre ha un’intensa attività erbivora che causa una drastica riduzione della massa delle macrofite che determina un forte impatto sulla biodiversità degli ecosistemi. È inoltre portatore sano della peste del gambero, dovuta al fungo Aphanomyces astaci, letale per tutte le specie locali. Le tecniche che sono state messe a punto durante il dottorato di ricerca sono: 1. l'utilizzo di esche a feromoni per il trappolaggio specie-specifico; 2. la sterilizzazione degli individui, con esche contenenti l’ormone gonado inibitorio (GIH); 3. la tecnica del rilascio di maschi sterili (SMRT). La prima metodologia si basa sui feromoni, sostanze chimiche prodotte dalle ghiandole a rosetta associate alla vescica urinaria nei Decapodi. In P. clarkii i feromoni sono rilasciati dalle femmine sessualmente mature per attrarre i maschi ricettivi e sono liberati attraverso l’urina. È stata prodotta una libreria in phage-display, una collezione di piccole proteine che sono fuse alle proteine fagiche, partendo dai tessuti della zona del nefroporo, delle ghiandole a rosetta, e dal rene (ghiandola verde) di femmine in periodo riproduttivo. La libreria è stata poi selezionata su antennule di maschi sessulamente attivi, sede dei recettori per i feromoni, per isolare molecole ad attività feromonale. Le selezioni sono state testate con esperimenti comportamentali di attrattività e una è risultata attrattiva nei confronti di maschi di P. clarkii. Con questa selezione sono state allestite le esche, costituite da una piastra petri forata contenente una matrice di alginato che ingloba le molecole della selezione. La validazione del sistema è stata eseguita attraverso prove in campo, presso il canale del Brancoletto, dove sono state posizionate nasse vuote, nasse con la nostra esca e nasse con una scatoletta di cibo per gatti. Con le prove è stata confermata l'attività attrattiva e la specie specificità dell’esca prodotta che cattura quasi esclusivamente esemplari di P. clarkii al contrario delle esche trofiche. La seconda tecnica prevede l’utilizzo dell’ormone gonado inibitorio, che inibisce la vitellogenesi nelle femmine e lo sviluppo dei testicoli nei maschi. L’ormone è prodotto dal complesso organo X-ghiandola del seno all’interno dei peduncoli oculari. L’obiettivo è stato quello di individuare un sistema per veicolare, attraverso il cibo (oral delivery), il GIH in modo da sterilizzare gli animali direttamente in natura semplicemente con la distribuzione di esche ormonali. La validazione dell'efficacia dell'oral delivery è stata effettuata con insulina umana e con l’ormone iperglicemizzante dei Crostacei (cHH) attraverso l’utilizzo di capsule ovvero palline di alginato, in cui è stato inglobato l’ormone mescolato a mangime per renderlo appetibile. Il rilevamento di insulina umana nell'emolinfa degli animali trattati dopo alcune ore dalla somministrazione ha dimostrato l'efficacia di questa formulazione. Gli esperimenti seguenti con il cHH non hanno dato i risultati sperati ed è stato deciso di sperimentare una tecnica differente che si basa sulla produzione di capsule mediante una microemulsione in cui il cHH è incluso in microgocce d’olio, a loro volta incluse in una matrice di alginato e chitosano. Questo sistema ha permesso di rilevare una differenza altamente significativa tra la glicemia degli animali trattati rispetto a quella degli animali di controllo. Viene così dimostrato l'assorbimento di dosi bioattive di ormoni peptidici attraverso il canale digerente utilizzando questa formulazione. La terza metodologia consiste nella sterilizzazione dei maschi e nel loro successivo rilascio in natura in modo che possano competere per l’accoppiamento con i maschi non trattati. Questa tecnica è già stata utilizzata per il controllo degli Insetti invasivi e i nostri dati confermano la possibilità di usarla anche per i Crostacei Decapodi. Sono stati analizati i danni del tessuto testicolare a differenti dosaggi di irradiazioni ionizzanti. Le radiazioni provocano ai vari dosaggi consistenti danni agli stadi precoci della spermatogenesi come dimostrato dalle differenze significative nel diametro medio degli acini analizzati in sezioni semifini a 10 e 30 giorni dal trattamento. L’analisi ultratsrutturale ha confermato la presenza di danni cellulari, in tutto il lobo testicolare ai vari dosaggi. Le radiazioni inducono danni permanenti e impediscono un regolare sviluppo dei testicoli, dimostrando di essere una tecnica eccellente per la sterilizzazione dei maschi di P. clarkii. I nostri dati individuano la dose di 40 Gy come il migliore compromesso tra i danni causati ai testicoli e i danni all’animale, in quanto i maschi irradiati non subiscono alterazioni significative nel comportamento riproduttivo. Tutte le tecniche innovative sviluppate durante il dottorato di ricerca hanno dato risultati estremamente interessanti evidenziando numerosi vantaggi nel loro utilizzo rispetto alle tecniche tradizionali. L’utilizzo delle esche a feromoni garantisce un minimo impatto sulla flora/fauna locale, dovuto solo al posizionamento delle trappole, e una gestione semplificata del trappolaggio intensivo in quanto non è richiesta una cernita degli animali presenti nella nassa. Il metodo autocida con le esche ormonali, per la sterilizzazione degli animali in natura, presenta numerosi vantaggi: il rilascio delle esche prima della stagione riproduttiva non richiede personale specializzato; il GIH è specie-specifico e non dovrebbe agire sul metabolismo di specie non bersaglio e, sebbene l'assorbimento non ha un’efficienza elevata, bastano dosi circolanti minime dell'ormone per esplicare la sua attività biologica. Infine la tecnica SMRT, nonostante la notevole variabilità del livello di sterilizzazione degli animali ad un certo dosaggio, costituisce, ad oggi, il metodo di controllo della diffusione del gambero rosso meno impegnativa sia dal punto di vista economico che gestionale in quanto la sterilizzazione e il rilascio dei maschi trattati possono essere eseguiti, in un solo giorno, con cadenza annuale. Ulteriori approfondimenti sono necessari per valutare l’applicabilità di queste tecniche per il controllo di popolazioni naturali, ma esse costituiscono senza dubbio una svolta significativa nelle ricerche del settore in quanto potrebbero garantire un drastico abbassamento dei costi nella gestione integrata delle popolazioni di P. clarkii.
XXVII Ciclo
1983
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Solayman, Md. "High-Throughput Sequencing Based Probing of Protein/RNA Structures and Functions." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/416290.

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The rapid advancement in sequencing chemistry, sequencing technologies, and bioinformatics has significantly increased the sequencing automation and lowered the cost. The applications of high-throughput sequencing (HTS) technologies are expanding from research laboratories to diagnostic clinics on a regular basis. Moreover, diverse methods used in epigenetics, proteomics, structure probing of macromolecules (DNA, RNA, and proteins) have been developed based on the HTS technology. This thesis describes the development of two novel techniques, high-throughput split-protein profiling (HiTS) and RNA solvent accessibility probing method (RL-Seq), broadening the applications of HTS technologies for probing protein/RNA structures and functions. Chapter 1 of the thesis provides an overview of the history of HTS technologies, available platforms, ongoing development in this field, and their diverse applications, particularly in the area of proteomics and RNA structure probing. In Chapter 2, we introduced the HiTS method that allowed fast identification of self- and assisted complementary positions of three antibiotic-resistant proteins (fosfomycin, fosA3; erythromycin, ermB; and chloramphenicol, catI resistant-proteins). The finding of suitable split sites in proteins is important because they are used as reporters in protein complementary assay (PCA) for studying protein-protein interactions in different organisms. However, only a small number of split-protein systems have been identified so far owing to manual, labourintensive optimization of the candidate genes. The proposed HiTS method employs transposon mutagenesis, conditional interaction of split fragments by rapamycin-regulated FRB-FKBP protein pairs, and deep sequencing for fast identification of self- and assisted complementary fragments, which are subsequently confirmed by low-throughput testing. In Chapter 3, we further applied the HiTS method on T7 RNA polymerase (T7 RNAP), a bacteriophage RNA polymerase, considering its importance in synthetic biology in addition to the PCA. We found that the newly developed HiTS method could also be applicable to T7 RNAP for locating suitable split sites for self-complementing variants. Several selfcomplementing variants were found and one with a stronger signal than the wild type one. In Chapter 4, in preparation of applying HTS technology to probe RNA solvent accessibility, we reviewed the available experimental and computational techniques for RNA solvent accessibility studies and identified existing research gaps. Current experimental approaches for studying RNA solvent accessibility include hydroxyl radical probing (HRF-Seq), light activated structural examination of RNA (LASER), and its modified versions (LASER-Seq, LASER-Map, and icLASER). The reactivity readouts of these methods are based on either the reverse transcriptase stop (RT-stop) at cleavage points or mutational profiling at adduct formation sites. These approaches rely on reverse transcriptase enzymes and random primers, which suffer from non-specific drop-off to create short truncated sequences, which successively lead to false-positive signals at probe-reactive sites. In Chapter 5, we proposed the RL-Seq (RtcB Ligation-Seq) method to overcome the abovementioned limitations of the existing approaches. The method is illustrated by measuring the solvent accessibility of Escherichia coli complete ribosomal complexes at the single-nucleotide resolution. In this method, unique properties of RtcB ligase were used to identify the probing sites by ligating a pre-defined 5′-OH end containing linker with the hydroxyl radicals cleavage generated 3′-P ends. The application of this method to ribosomal RNAs (23S, 16S, and 5S rRNAs) confirmed its ability to estimate solvent accessibility with high sensitivity (required low sequencing depth) and accuracy (strong correlation to structure-derived values). In addition, the pre-defined linker employed in this method allowed using of a fixed primer in reverse transcription reaction and significantly minimized the biases during subsequent PCR amplification. In Chapter 6, we discussed the future prospects of these HTS technology-based methods developed in this thesis.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Institute for Glycomics
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Přibylová, Ivana. "Útěšná smrt - pojednání o smrti v raném novověku." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-408305.

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The first part deals about death at the end of 16 th and beginning of 17 th century. For orientation in Baroque color the work includes part pertaining to burials, which were indispensable social rituals of that era. The mention is about plague, that killed both, Catholics, non-Catholics and unbelievers. Part two points out to the era invention of book printing. In short deals about works, based on the idea of death. The sermon was dedicated mainly to husband of deceased. So it is briefly discussed the person of one of the representatives of the Waldstein family, Jiří. The main part is a sermon, which was published in printed form and was accompanied with two articles, namely Artyculy. A message to all believers, that soul of believers asscents to heaven. Annendung from "a printer's pen" concludes whole little file of Matěj Klesel, pastor of Hostinné. Burial sermons of of Early modern age contained large ammont of quations from Old and New Testament, quatations of the Church Fathers and other popular autthors of that era. There are included directly to original text. They motify readers, how to behave in life to reach redumption and offer the help for after live Part of my work is a basic statement about the text, after which followes text analysis and summary. The aim of this work is to make the...
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POLÁČKOVÁ, Ludmila. "Smrt v literatuře versus tvář smrti v dnešní společnosti." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-393880.

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This diploma thesis looks into the issues of death and dying. Based on a chosen work of fiction, it endeavours to remit the topic of fear of dying and concerns on the possibilities of how to deal with it from points of view of a dying person as well as that of an accompanying one. By using and connecting approaches used in sociology of literature and social work, it aims to appraise the benefit of reading fiction on the given topic for social workers in their professional as well as personal life. The work of fiction therefore serves as an alternative receptive material. By its interpretation, a social worker or layman can gain a more profound knowledge of current social issues, which the last matters of a human unquestionably belong to.
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Books on the topic "SMRT"

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Havlíček, Jaroslav. Smrt bibliomanova. Praha: Nakl. Brody, 1997.

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Merc, Dušan. Dantejeva smrt. Maribor: Litera, 2007.

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Bijela smrt. Rijeka: Adamić, 2004.

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Drakul, Simon. Ili smrt. Skopje: Goce Delčev, 1989.

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Euripidova smrt. Beograd: "Filip Višnjiʹc", 2002.

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Putnikova smrt. Zaprešić: Fraktura, 2003.

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Kranjc, Tomaž. Smrt sem. Ljubljana: Gimnazija Šentvid, 1999.

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Kocevski, Danilo. Poetovata smrt. Skopje: Kultura, 1995.

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Vučković, Radovan. Smrt, buđenje. Beograd: Svet knjige, 2011.

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Michlová, Marie. Smrt Múz. Praha: Torst, 2011.

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Book chapters on the topic "SMRT"

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Džaji, Harris. "Selimovi, Meša: Derviš i smrt." In Kindlers Literatur Lexikon (KLL), 1–2. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_22399-1.

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KLL and Nedžad Ćudić. "Mažuranić, Ivan: Smrt Smail-Age Čengića." In Kindlers Literatur Lexikon (KLL), 1–2. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_16089-1.

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Privalsky, M. L. "Regulation of SMRT and N-CoR Corepressor Function." In Current Topics in Microbiology and Immunology, 117–36. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-662-10595-5_6.

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Xia, Zeyu, Yingbo Cui, Ang Zhang, Peng Zhang, Sifan Long, Tao Tang, Lin Peng, Chun Huang, Canqun Yang, and Xiangke Liao. "Large-Scale Parallel Alignment Algorithm for SMRT Reads." In Algorithms and Architectures for Parallel Processing, 213–29. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-95388-1_14.

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Bottacini, Francesca, and Douwe van Sinderen. "Bifidobacterium Genome Assembly and Methylome Analysis Using Pacbio SMRT Sequencing." In Methods in Molecular Biology, 225–32. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1274-3_18.

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Andhare, Devika, Sachin S. Holkar, and Thomas J. Pucadyil. "SMrT Assay for Real-Time Visualization and Analysis of Clathrin Assembly Reactions." In Clathrin-Mediated Endocytosis, 161–75. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8719-1_12.

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Tellgren-Roth, Christian, and Mohea Couturier. "Detecting DNA Methylations in the Hyperthermoacidophilic Crenarchaeon Sulfolobus acidocaldarius Using SMRT Sequencing." In Prokaryotic Gene Regulation, 39–50. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2413-5_3.

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Yang, Yao, and Stuart A. Scott. "DNA Methylation Profiling Using Long-Read Single Molecule Real-Time Bisulfite Sequencing (SMRT-BS)." In Methods in Molecular Biology, 125–34. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7231-9_8.

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Ambardar, Sheetal, and Malali Gowda. "High-Resolution Full-Length HLA Typing Method Using Third Generation (Pac-Bio SMRT) Sequencing Technology." In Methods in Molecular Biology, 135–53. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8546-3_9.

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Ghosh, Soumyadyuti, Soumyajit Dey, and Debdeep Mukhopadhyay. "SMarT: A SMT Based Privacy Preserving Smart Meter Streaming Methodology." In Security, Privacy, and Applied Cryptography Engineering, 267–86. Cham: Springer Nature Switzerland, 2022. http://dx.doi.org/10.1007/978-3-031-22829-2_15.

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Conference papers on the topic "SMRT"

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Muftić, Edin. "„Smrt je kalež, a čovjek je kušač“: smrt u starijoj arapskoj poeziji." In Desničini susreti 2017. Filozofski fakultet u Zagrebu, FF Press, 2018. http://dx.doi.org/10.17234/desnicini_susreti2017.20.

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Cvitković, Miran, and Ante Klarić. "Ali lahko zdravnik dovoli pacientovo smrt?" In 27. posvetovanje Medicina, pravo in družba: Sodobni izzivi in dileme. Unviersity of Maribor Press, 2018. http://dx.doi.org/10.18690/978-961-286-147-6.7.

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Šeatović, Svetlana. "Smrt građanske elite u Zimskom ljetovanju." In Desničini susreti 2017. Filozofski fakultet u Zagrebu, FF Press, 2018. http://dx.doi.org/10.17234/desnicini_susreti2017.15.

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Anušić, Nikola. "Kad smrt poždere smrt: utjecaj pandemije španjolske gripe iz 1918. godine na dinamiku patocenične promjene u sjevernoj Hrvatskoj." In Desničini susreti 2017. Filozofski fakultet u Zagrebu, FF Press, 2018. http://dx.doi.org/10.17234/desnicini_susreti2017.30.

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Ikbal, Febina, and R. Gopikakumari. "Watermarking using SMRT on Grayscale Images and Attack analysis." In TENCON 2019 - 2019 IEEE Region 10 Conference (TENCON). IEEE, 2019. http://dx.doi.org/10.1109/tencon.2019.8929427.

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Korlach, Jonas. "Single-Molecule, Real-Time (SMRT™) Monitoring of Biomolecules." In Bio-Optics: Design and Application. Washington, D.C.: OSA, 2011. http://dx.doi.org/10.1364/boda.2011.bwc1.

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Petković, Nikola. "Smrt i međustanje u radovima Juana Rulfa i Dževada Karahasana." In Desničini susreti 2017. Filozofski fakultet u Zagrebu, FF Press, 2018. http://dx.doi.org/10.17234/desnicini_susreti2017.24.

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Petrović, Dragana. "PRAVO NA DOSTOJANSTVENU SMRT U ITALIJANSKOM PRAVU – ŽIVOT U MREŽI." In XVIII Majsko savetovanje. University of Kragujevac, Faculty of Law, 2022. http://dx.doi.org/10.46793/xviiimajsko.647p.

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The topic is important, difficult, tedious, burdensome ... Nothing changes here, ever. Dying, fear, pain, suffering, anxiety, apathy ... No one is exempt from that "story". Death is necessary. Life always ends in death. It is a journey into the unknown which, from the point of view of a long and happy life, produces great disorder and fierce frustrations. A series of big attitudes is simply imposed. Opinions are exaggerated in one direction or another. Black and white!? In fact, the stupid extremes, even the "ways" used in doing so, were for many worthy of a "merciful" end to life. Life itself, the author points out, directs us to reject all theoretical extremes. However, it seems to us that we would not have done better in this field, even under more moderate, much more favorable conditions. In that too much confusion, it's just important to keep a little more rational !? The "right solution", or if we want "satisfactory" will already come up !? In that context, with the risk of repeating some of what was said, our attention was specifically drawn to the punishment of the perpetrator of the relevant act in Italian law. It should be noted that the picture provided by the study of this complex and provocative issue is in fact a mirror of the specific relationship between legislative solutions, especially in the area of responsibility and punishment of the main actors of "euthanasia" and "suicide assistance", and complicated life situations. which they will, we shall see, differ considerably. Finally, as the author points out, the views discussed here seem to provide an opportunity to open up some new vistas, it may shed light on the problem from a different perspective and offer a different way of resolving the aforementioned, very complex and difficult issues that arise in connection with it.
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Vukomanović Rastegorac, Vladimir. "Šašava besmrtnost i garava smrt: predstave ljudske smrti u poeziji za decu i mlade Miroslava Antića." In Desničini susreti 2017. Filozofski fakultet u Zagrebu, FF Press, 2018. http://dx.doi.org/10.17234/desnicini_susreti2017.22.

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Khayrallah, Huda, and João Sedoc. "SMRT Chatbots: Improving Non-Task-Oriented Dialog with Simulated Multiple Reference Training." In Findings of the Association for Computational Linguistics: EMNLP 2020. Stroudsburg, PA, USA: Association for Computational Linguistics, 2020. http://dx.doi.org/10.18653/v1/2020.findings-emnlp.403.

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Reports on the topic "SMRT"

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Miller, Jack, and Marie-Laure Hicks. Small Modular Nuclear Reactors. Parliamentary Office of Science and Technology, July 2018. http://dx.doi.org/10.58248/pn580.

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There is growing UK and international interest in using ‘small modular nuclear reactors’ (SMRs) to generate electricity, and the UK Government announced a number of measures to support SMR development in the 2018 Nuclear Sector Deal. Stakeholders suggest that, compared with conventional nuclear reactors, SMRs could offer cost savings to operators and consumers, more flexible energy production and a greater choice of potential sites. This note examines key aspects of SMR technology, their economics and regulation.
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DEMIROVA, V., and M. VAZINA. SMART TECHNOLOGY “SMART CITY” (LITERATURE REVIEW). Science and Innovation Center Publishing House, 2021. http://dx.doi.org/10.12731/2070-7568-2021-10-5-1-54-59.

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The article analyzes the current concept of the development of urban areas “Smart City”, which involves the integration of various information and communication technologies for the management of urban infrastructure. The article analyzes the concept of smart technologies and the prospects of their use for the development of urban infrastructure of the future.
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Carrasco, Carlos, Pedro Franca, Joan Enric Ricart, Jordi Salvador, and Albert Tapia. Financing Smart Solutions in Cities: Smart Financing. Servicio de Publicaciones de la Universidad de Navarra, November 2019. http://dx.doi.org/10.15581/018.op-325.

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Baldessari, Gianni, Oliver Bender, Domenico Branca, Luigi Crema, Anna Giorgi, Nina Janša, Janez Janša, Marie-Eve Reinert, and Jelena Vidović. Smart Altitude. Edited by Annemarie Polderman, Andreas Haller, Chiara Pellegrini, Diego Viesi, Xavier Tabin, Chiara Cervigni, Stefano Sala, et al. Verlag der Österreichischen Akademie der Wissenschaften, March 2021. http://dx.doi.org/10.1553/smart-altitude.

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This final report summarizes the outcomes of the Smart Altitude project. The Smart Altitude project ran from June 2018 to April 2021 and was carried out by ten partners from six different countries in the Alpine Space (Austria, France, Italy, Germany, Slovenia, and Switzerland). The project was co-financed by the European Union via Interreg Alpine Space. The aim of the project was to enable and accelerate the implementation of low-carbon policies in winter tourism regions by demonstrating the efficiency of a step-by-step decision support tool for energy transition in four Living Labs. The project targeted policymakers, ski resort operators, investors, tourism, and entrepreneurship organizations. The Smart Altitude approach was designed to ensure suitability across the Alpine Space, thereby fostering its replication and uptake in other winter tourism regions and thus increasing the resilience of mountain areas.
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Truyol, Sabine. Smart Microgrids. Office of Scientific and Technical Information (OSTI), September 2022. http://dx.doi.org/10.2172/1886774.

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Nirm V. Nirmalan. SMART POWER TURBINE. Office of Scientific and Technical Information (OSTI), November 2003. http://dx.doi.org/10.2172/833266.

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Petry, Frederick, Ted Tsui, John Cook, Lucy Smedstad, and James Dykes. Smart Climatology System. Fort Belvoir, VA: Defense Technical Information Center, September 2010. http://dx.doi.org/10.21236/ada530518.

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Haykin, Martha E., and Robert B. J. Warnar. Smart card technology. Gaithersburg, MD: National Bureau of Standards, 1988. http://dx.doi.org/10.6028/nist.sp.500-157.

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Kachru, Ravinder. Smart Optical Memory. Fort Belvoir, VA: Defense Technical Information Center, September 1997. http://dx.doi.org/10.21236/ada330667.

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Koberstein, Jeffrey T. Smart Polymer Surfaces. Fort Belvoir, VA: Defense Technical Information Center, February 2009. http://dx.doi.org/10.21236/ada509097.

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