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Journal articles on the topic 'SMTr'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

da Silva, Tânia Regina Marques, Juliana Ribeiro de Freitas, Queilan Chagas Silva, et al. "Virulent Mycobacterium fortuitum Restricts NO Production by a Gamma Interferon-Activated J774 Cell Line and Phagosome-Lysosome Fusion." Infection and Immunity 70, no. 10 (2002): 5628–34. http://dx.doi.org/10.1128/iai.70.10.5628-5634.2002.

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ABSTRACT The virulence of different isolates of Mycobacterium has been associated with two morphologically distinguishable colonial variants: opaque (SmOp) and transparent (SmTr). In this report we used an in vitro assay to compare macrophage (Mφ) responses to SmOp and SmTr Mycobacterium fortuitum variants, taking advantage of the fact that these variants were derived from the same isolate. Cells preactivated or not with gamma interferon (IFN-γ) were infected with SmOp or SmTr M. fortuitum. We showed that SmOp and SmTr induced different levels of nitric oxide (NO) production by IFN-γ-stimulate

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2

Parent, Mélissandre, and Isabelle Blanchette. "La stimulation magnétique transcrânienne répétitive est-elle efficace pour traiter les troubles anxieux?" Neuropsychologie clinique et appliquée 1, Fall 2017 (2017): 56–73. http://dx.doi.org/10.46278/j.ncacn.20170813.

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Un tiers des personnes souffrant d’un trouble anxieux ne répond pas aux traitements conventionnels. La stimulation magnétique transcrânienne répétitive (SMTr) pourrait être un traitement complémentaire ou alternatif pour tenter de soigner ces personnes. Dans cet article, nous décrivons l’état des connaissances actuelles dans ce domaine de recherche émergeant concernant l’efficacité du traitement de la SMTr pour traiter certains troubles anxieux (selon le DSM-IV-TR). Le trouble de stress post-traumatique, le trouble obsessionnel-compulsif et le trouble panique sont les troubles anxieux les plus

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3

Durand, F., C. Gaudeau-Bosma, V. Moulier, et al. "Effet de la stimulation magnétique transcrânienne répétitive (rTMS) sur une tâche de N-back avec leurre : étude randomisée en double insu." European Psychiatry 29, S3 (2014): 545. http://dx.doi.org/10.1016/j.eurpsy.2014.09.329.

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ContexteLa stimulation magnétique transcrânienne répétitive (SMTr) appliquée sur le cortex préfrontal dorso-latéral (CPFDL) a prouvé son efficacité dans le traitement de la dépression résistante [1]. En plus d’une amélioration sur la symptomatologie, des études rapportent des effets positifs sur le fonctionnement cognitif [2], dont la mémoire de travail. Cependant, cet effet ne semble pas être retrouvé chez des sujets sains [3] lors d’une tâche de N-back sans leurre. L’objectif de notre étude est donc d’évaluer l’impact de la SMTr sur le CPFDL, région plus sensible à une tâche de N-back avec l

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4

Pal, Rajinder, Gulshan Mahajan, Virender Sardana, Bavita Asthir, and Bhagirath Singh Chauhan. "Performance of Dry-Seeded Rice Genotypes under Varied Soil Moisture Regimes and Foliar-Applied Hormones." Plants 9, no. 4 (2020): 539. http://dx.doi.org/10.3390/plants9040539.

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Plant hormones influence various physiological processes during the growth and development of plants, but their critical roles in influencing yield and antioxidant activities in dry-seeded rice (DSR) have not been adequately explored. This study aims to analyze the performance and antioxidant activity of contrasting genotypes of DSR in response to soil moisture regimes and foliar-applied hormones. The study comprised sixteen treatments that were evaluated under field conditions as per split-plot design in three replications. Treatments comprised combinations of two soil moisture tension regime

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5

Young, Adam M. H., Mathew R. Guilfoyle, Helen Fernandes, Matthew R. Garnett, Shruti Agrawal, and Peter J. Hutchinson. "The application of adult traumatic brain injury models in a pediatric cohort." Journal of Neurosurgery: Pediatrics 18, no. 5 (2016): 558–64. http://dx.doi.org/10.3171/2016.5.peds15427.

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OBJECTIVE There is increasing interest in the use of predictive models of outcome in adult head injury. Two international models have been identified to be reliable modalities for predicting outcome: the Corticosteroid Randomisation After Significant Head Injury (CRASH) model, and the International Mission on Prognosis and Analysis of randomized Controlled Trials in TBI (IMPACT) model. However, these models are designed only to identify outcomes in adult populations. METHODS A retrospective analysis was performed on pediatric patients with severe traumatic brain injury (TBI) admitted to the pe

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6

Carland, Francine, Shozo Fujioka, and Timothy Nelson. "The Sterol Methyltransferases SMT1, SMT2, and SMT3 Influence Arabidopsis Development through Nonbrassinosteroid Products." Plant Physiology 153, no. 2 (2010): 741–56. http://dx.doi.org/10.1104/pp.109.152587.

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7

Pérocheau, Dominique, Françoise Laroche, and Serge Perrot. "Traitement de la douleur en rhumatologie : la stimulation magnétique transcrânienne répétitive (SMTr), une nouvelle approche en développement." Revue du Rhumatisme 80, no. 6 (2013): 559–63. http://dx.doi.org/10.1016/j.rhum.2013.04.006.

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8

Hodaj, Hasan, Jean-Pierre Alibeu, Caroline Maindet Dominici, David Szekely, and Claude Jacquot. "Traitement des douleurs réfractaires de la face par la stimulation magnétique transcrânienne répétitive (SMTr) : étude ouverte sur une année." Douleurs : Evaluation - Diagnostic - Traitement 11, no. 6 (2010): 280–87. http://dx.doi.org/10.1016/j.douler.2010.09.001.

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9

Eraiah, B. "Optical Properties of Erbium doped Molybdenum Tellurite Glasses." Mapana - Journal of Sciences 15, no. 1 (2016): 17–27. http://dx.doi.org/10.12723/mjs.36.2.

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The glasses with the composition of xEr 2 O 3 -5AgCl- 15MoO 3 -(80-x) TeO 2 (x = 0, 0.5 and 1 mol%, named as SMT0, SMT1 and SMT2, respectively) were synthesized using conventional melt quenching method and their optical properties were investigated through UV-Visible spectrophotometer. Density and molar volume values of the glass samples were estimated, their values were found in the range from 5.52 to 5.64 g/cm 3 and 27.737 to 28.689 cm 3 , respectively. The UV absorption spectra were recorded at room temperature in the wavelength range 200-1100nm. From the absorption edge data, it is found t

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10

Hodaj, H., J. M. Pellat, D. Szekely, J. P. Alibeu, T. Bougerol, and C. Jacquot. "CC03 Utilisation de la stimulation magnétique transcranienne répétitive (SMTR) dans le traitement de la douleur neuropathique chronique résistante aux thérapeutiques conventionnelles." Douleurs : Evaluation - Diagnostic - Traitement 8 (October 2007): 62–63. http://dx.doi.org/10.1016/s1624-5687(07)73135-9.

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11

Li, Shyr-Jiann, and Mark Hochstrasser. "The Yeast ULP2 (SMT4) Gene Encodes a Novel Protease Specific for the Ubiquitin-Like Smt3 Protein." Molecular and Cellular Biology 20, no. 7 (2000): 2367–77. http://dx.doi.org/10.1128/mcb.20.7.2367-2377.2000.

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ABSTRACT Yeast Smt3 and its vertebrate homolog SUMO-1 are ubiquitin-like proteins (Ubls) that are reversibly ligated to other proteins. LikeSMT3, SMT4 was first isolated as a high-copy-number suppressor of a defective centromere-binding protein. We show here that SMT4 encodes an Smt3-deconjugating enzyme, Ulp2. In cells lacking Ulp2, specific Smt3-protein conjugates accumulate, and the conjugate pattern is distinct from that observed in a ulp1ts strain, which is defective for a distantly related Smt3-specific protease, Ulp1. The ulp2Δ mutant exhibits a pleiotropic phenotype that includes tempe

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12

Jalenques, I., G. Legrand, E. Vaille-Perret, R. Tourtauchaux, and F. Galland. "Efficacité et tolérance de la stimulation magnétique transcrânienne (SMTr) dans le traitement des dépressions chez le sujet âgé : revue de la littérature." L'Encéphale 36 (June 2010): D105—D118. http://dx.doi.org/10.1016/j.encep.2009.10.007.

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13

Rastelli, F., M. Toba, C. Tchokotche, et al. "Stimulation Magnétique Transcranienne répétitive (SMTr) dans le traitement de la négligence spatiale chez les patients cérébrolésés droits : présentation d’une étude clinique multicentrique en double insu." Annals of Physical and Rehabilitation Medicine 54 (October 2011): e217-e218. http://dx.doi.org/10.1016/j.rehab.2011.07.400.

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14

Szwed, Aleksandra, Katarzyna Miłowska, Sylwia Michlewska, et al. "Generation Dependent Effects and Entrance to Mitochondria of Hybrid Dendrimers on Normal and Cancer Neuronal Cells In Vitro." Biomolecules 10, no. 3 (2020): 427. http://dx.doi.org/10.3390/biom10030427.

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Dendrimers as drug carriers can be utilized for drugs and siRNA delivery in central nervous system (CNS) disorders, including various types of cancers, such as neuroblastomas and gliomas. They have also been considered as drugs per se, for example as anti-Alzheimer’s disease (AD), anti-cancer, anti-prion or anti-inflammatory agents. Since the influence of carbosilane–viologen–phosphorus dendrimers (SMT1 and SMT2) on the basic cellular processes of nerve cells had not been investigated, we examined the impact of two generations of these hybrid macromolecules on two murine cell lines—cancer cell

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15

Toba, M., F. Rastelli, C. Tchokothe, et al. "Utilisation de la Stimulation Magnetique Transcraniene répétitive (SMTr) dans la rééducation de la négligence spatiale unilatérale après accident vasculaire cérébral : bases théoriques et données préliminaires du projet PHRC régional « NEGLECT »." Annals of Physical and Rehabilitation Medicine 54 (October 2011): e217. http://dx.doi.org/10.1016/j.rehab.2011.07.399.

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16

Schaeffer, Aurélie, Pierrette Bouvier-Navé, Pierre Benveniste, and Hubert Schaller. "Plant sterol-C24-methyl transferases: Different profiles of tobacco transformed with SMT1 or SMT2." Lipids 35, no. 3 (2000): 263–69. http://dx.doi.org/10.1007/s11745-000-0522-1.

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17

Rey, C., A. Rico, P. Asquinazi, et al. "Effet de la stimulation magnétique transcrânienne répétitive (SMTR) appliquée sur le cortex moteur primaire, sur la spasticité des membres inférieurs (MI) et la plasticité cérébrale chez des patients présentant une sclérose en plaques (SEP)." Revue Neurologique 169 (April 2013): A113—A114. http://dx.doi.org/10.1016/j.neurol.2013.01.272.

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18

Chaudhuri, Mainak, and Mark Heinrich. "SMTp." ACM SIGARCH Computer Architecture News 32, no. 2 (2004): 124. http://dx.doi.org/10.1145/1028176.1006712.

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19

Poizat, Jean-Claude, and Françoise Dasturová. "Smrt." REFLEXE 2019, no. 57 (2020): 143–60. http://dx.doi.org/10.14712/25337637.2020.11.

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20

Barbara Gunawan and Diesy Nurfithriyani. "PREDIKSI FINANCIAL DISTRESS PADA BUMN DALAM RANGKA MENILAI KINERJA PERUSAHAAN PEMERINTAH." Jurnal Aplikasi Akuntansi 4, no. 1 (2019): 59–76. http://dx.doi.org/10.29303/jaa.v4i1.73.

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Badan Usaha Milik Negara (BUMN) memiliki peran dalam peningkatan pendapatan negara melalui pembayaran pajak dan setoran deviden perusahaan, namun permasalahan yang dihadapi saat ini adalah hutang yang dimiliki BUMN semakin meningkat dikarenakan komitmen pemerintah pada pembiayaan perusahaan kurang optimal sehingga memungkinkan perusahaan berada pada kondisi kesulitan keuangan. Penelitian ini bertujuan untuk memprediksi kesulitan keuangan atau financial distress perusahaan BUMN bidang industri pengolahan selama 2014-2018 dan menganalisis kestabilan kinerja perusahaan pada tahun tersebut. Predik

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21

Nikolić, Milica, and Radomir Konstantinović. "Dekartova smrt." World Literature Today 72, no. 3 (1998): 653. http://dx.doi.org/10.2307/40154171.

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22

Koch, Linda. "SMRT move?" Nature Reviews Genetics 15, no. 3 (2014): 146. http://dx.doi.org/10.1038/nrg3678.

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23

Dupont, H., D. Dupont-Perdrizet, and JL Lupéron. "Smur et charge en soins: Codage activité smur (CAS)." Annales Françaises d'Anesthésie et de Réanimation 16, no. 6 (1997): 721. http://dx.doi.org/10.1016/s0750-7658(97)86240-5.

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24

Akhmedova, N. R., S. M. Agapashaeva, and O. M. Aliev. "Physicochemical study of SmTe-In2Te3 and SmTe-InTe systems." Russian Journal of Inorganic Chemistry 54, no. 10 (2009): 1662–63. http://dx.doi.org/10.1134/s0036023609100258.

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25

Stanya, Kristopher J., Yu Liu, Anthony R. Means, and Hung-Ying Kao. "Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT." Journal of Cell Biology 183, no. 1 (2008): 49–61. http://dx.doi.org/10.1083/jcb.200806172.

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Silencing mediator for retinoic acid and thyroid hormone receptor (SMRT) is a transcriptional corepressor that participates in diverse signaling pathways and human diseases. However, regulation of SMRT stability remains largely unexplored. We show that the peptidyl-prolyl isomerase Pin1 interacts with SMRT both in vitro and in mammalian cells. This interaction requires the WW domain of Pin1 and SMRT phosphorylation. Pin1 regulates SMRT protein stability, thereby affecting SMRT-dependent transcriptional repression. SMRT phosphorylation at multiple sites is required for Pin1 interaction, and the

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26

Franke, Julian. "The death of the author | the death of the architect: Meaning in architecture and the role of users." SAJ - Serbian Architectural Journal 10, no. 1 (2018): 1–12. http://dx.doi.org/10.5937/saj1801001f.

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In his work The Death of the Author (1967), Roland Barthes creates a new definition of authorship, in that the author is not the real originator of meaning in literature, but rather the reader. This questions the influence and responsibility of originators in creative fields in general. This paper applies Barthes's thesis to the profession of architecture. Therefore the role of users is discussed, as well as meaning and language in architecture. With the help of the semiotic work by Umberto Eco and texts by Roman Ingarden and Jonathan Hill, the paper will attempt to show how the sole image of

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27

Samuel, James, Linda Beck, Jessica Appler, et al. "AOAC SMPR 2015.011." Journal of AOAC INTERNATIONAL 99, no. 1 (2016): 298–302. http://dx.doi.org/10.5740/jaoac.int.smpr2015.011.

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28

Ostlund, Eileen, Jessica Appler, Jeff Ballin, et al. "AOAC SMPR 2015.012." Journal of AOAC INTERNATIONAL 99, no. 1 (2016): 303–7. http://dx.doi.org/10.5740/jaoac.int.smpr2015.012.

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Tallent, Sandra M., Jessica Appler, Patrice Arbault, et al. "AOAC SMPR 2015.013." Journal of AOAC International 99, no. 1 (2016): 308–12. http://dx.doi.org/10.5740/jaoac.int.smpr2015.013.

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30

Zhang, Yanjun, Joseph M. Betz, James Griffiths, et al. "AOAC SMPR 2015.014." Journal of AOAC INTERNATIONAL 99, no. 1 (2016): 314–17. http://dx.doi.org/10.5740/jaoac.int.smpr2015.014.

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31

Ingle, Prashant, W. Bradley Barrett, Clyde Don, et al. "AOAC SMPR 2015.015." Journal of AOAC INTERNATIONAL 99, no. 1 (2016): 318–19. http://dx.doi.org/10.5740/jaoac.int.smpr2015.015.

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32

Austad, John, W. Bradley Barrett, Joseph M. Betz, et al. "AOAC SMPR 2015.016." Journal of AOAC INTERNATIONAL 99, no. 1 (2016): 320–21. http://dx.doi.org/10.5740/jaoac.int.smpr2015.016.

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33

Vetter, Monica L. "Methylation Gets SMRT." Developmental Cell 5, no. 3 (2003): 359–60. http://dx.doi.org/10.1016/s1534-5807(03)00267-3.

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34

Watkins, Rosemary C. "New SMTE Handbook." Journal of Music Teacher Education 4, no. 2 (1995): 3–5. http://dx.doi.org/10.1177/105708379500400201.

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35

Vukčević, Vladan. "Iznenadna srčana smrt." Srce i krvni sudovi 30, no. 4 (2011): 175–76. http://dx.doi.org/10.5937/siks1103175v.

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36

Hasumi, Keiji, and Eriko Suzuki. "Impact of SMTP Targeting Plasminogen and Soluble Epoxide Hydrolase on Thrombolysis, Inflammation, and Ischemic Stroke." International Journal of Molecular Sciences 22, no. 2 (2021): 954. http://dx.doi.org/10.3390/ijms22020954.

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Stachybotrys microspora triprenyl phenol (SMTP) is a large family of small molecules derived from the fungus S. microspora. SMTP acts as a zymogen modulator (specifically, plasminogen modulator) that alters plasminogen conformation to enhance its binding to fibrin and subsequent fibrinolysis. Certain SMTP congeners exert anti-inflammatory effects by targeting soluble epoxide hydrolase. SMTP congeners with both plasminogen modulation activity and anti-inflammatory activity ameliorate various aspects of ischemic stroke in rodents and primates. A remarkable feature of SMTP efficacy is the suppres

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37

Li, Hui, Christopher Leo, Daniel J. Schroen, and J. Don Chen. "Characterization of Receptor Interaction and Transcriptional Repression by the Corepressor SMRT." Molecular Endocrinology 11, no. 13 (1997): 2025–37. http://dx.doi.org/10.1210/mend.11.13.0028.

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Abstract SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) are two related transcriptional corepressors that contain separable domains capable of interacting with unliganded nuclear receptors and repressing basal transcription. To decipher the mechanisms of receptor interaction and transcriptional repression by SMRT/N-CoR, we have characterized protein-protein interacting surfaces between SMRT and nuclear receptors and defined transcriptional repression domains of both SMRT and N-CoR. Deletional analysis reveals two individual nucl

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Amano, Izuki, Ayane Ninomiya, Megan Ritter, Kristen R. Vella, Anthony Neil Hollenberg, and Noriyuki Koibuchi. "Nuclear Receptor Corepressors NCoR1 and SMRT Plays Unique Roles in Central Nervous System." Journal of the Endocrine Society 5, Supplement_1 (2021): A976. http://dx.doi.org/10.1210/jendso/bvab048.1995.

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Abstract The nuclear corepressor 1 (NCoR1) and the silencing mediator of retinoid and thyroid hormone receptors (SMRT) are critical coregulators of the thyroid hormone receptor (TR), mediating transcriptional repression via histone deacetylation. Thyroid hormone (TH) plays an essential role in many physiological processes via the TR. How the corepressors regulate TR signaling is not fully understood, especially in central nervous system (CNS). To determine the role of NCoR1 and SMRT in the CNS, we used mice with conditional NCoR1 (NCoR1lox/lox) and SMRT (SMRTlox/lox) alleles in combination wit

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Templier, F., T. Lœb, B. Vincent, F. Bouvet, M. Baer, and J. Pasteyer. "Smur des villes et smur des champs: epidemiologie de la traumatologie." Annales Françaises d'Anesthésie et de Réanimation 16, no. 6 (1997): 714. http://dx.doi.org/10.1016/s0750-7658(97)86225-9.

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40

Hong, Suk-Hyun, and Martin L. Privalsky. "The SMRT Corepressor Is Regulated by a MEK-1 Kinase Pathway: Inhibition of Corepressor Function Is Associated with SMRT Phosphorylation and Nuclear Export." Molecular and Cellular Biology 20, no. 17 (2000): 6612–25. http://dx.doi.org/10.1128/mcb.20.17.6612-6625.2000.

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ABSTRACT The SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressor participates in the repression of target gene expression by a variety of transcription factors, including the nuclear hormone receptors, promyelocytic leukemia zinc finger protein, and B-cell leukemia protein 6. The ability of SMRT to associate with these transcription factors and thereby to mediate repression is strongly inhibited by activation of tyrosine kinase signaling pathways, such as that represented by the epidermal growth factor receptor. We report here that SMRT function is potently inhi

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Sun, Qian, Sze Wan Cheng, Kelton Cheung, Marianne M. Lee, and Michael K. Chan. "Cry Protein Crystal-Immobilized Metallothioneins for Bioremediation of Heavy Metals from Water." Crystals 9, no. 6 (2019): 287. http://dx.doi.org/10.3390/cryst9060287.

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Cry proteins have been the subject of intense research due to their ability to form crystals naturally in Bacillus thuringiensis (Bt). In this research we developed a new strategy that allows for the removal of cadmium and chromium from wastewater by using one Cry protein, Cry3Aa, as a framework to immobilize tandem repeats of the cyanobacterial metallothionein SmtA from Synechococcus elongatus (strain PCC 7942). SmtA is a low molecular weight cysteine-rich protein known to bind heavy metals. A series of Cry3Aa-SmtA constructs were produced by the fusion of one, three, or six tandem repeats of

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Newman, Jane D., Meghan M. Russell, Lixin Fan, Yun-Xing Wang, Giovanni Gonzalez-Gutierrez, and Julia C. van Kessel. "The DNA binding domain of the Vibrio vulnificus SmcR transcription factor is flexible and binds diverse DNA sequences." Nucleic Acids Research 49, no. 10 (2021): 5967–84. http://dx.doi.org/10.1093/nar/gkab387.

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Abstract Quorum sensing gene expression in vibrios is regulated by the LuxR/HapR family of transcriptional factors, which includes Vibrio vulnificus SmcR. The consensus binding site of Vibrio LuxR/HapR/SmcR proteins is palindromic but highly degenerate with sequence variations at each promoter. To examine the mechanism by which SmcR recognizes diverse DNA sites, we generated SmcR separation-of-function mutants that either repress or activate transcription but not both. SmcR N55I is restricted in recognition of single base-pair variations in DNA binding site sequences and thus is defective at t

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43

Yuan, Wei, Qian Hu, Jiao Zhang, Feng Huang, and Jing Liu. "Hydrophobic Modification of Graphene Oxide and Its Effect on the Corrosion Resistance of Silicone-Modified Epoxy Resin." Metals 11, no. 1 (2021): 89. http://dx.doi.org/10.3390/met11010089.

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This study modified graphene oxide (GO) with hydrophilic octadecylamine (ODA) via covalent bonding to improve its dispersion in silicone-modified epoxy resin (SMER) coatings. The structural and physical properties of ODA-GO were characterized by field-emission scanning electron microscopy (FE-SEM), X-ray diffraction analysis (XRD), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and contact angle tests. The ODA-GO composite materials were added to SMER coatings by physical mixing. FE-SEM, water absorption, and contact angle tests wer

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Blackmore, Julia K., Sudipan Karmakar, Guowei Gu та ін. "The SMRT Coregulator Enhances Growth of Estrogen Receptor-α-Positive Breast Cancer Cells by Promotion of Cell Cycle Progression and Inhibition of Apoptosis". Endocrinology 155, № 9 (2014): 3251–61. http://dx.doi.org/10.1210/en.2014-1002.

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Abstract The SMRT coregulator functions as a dual coactivator and corepressor for estrogen receptor-α (ERα) in a gene-specific manner, and in several studies its elevated expression correlates with poor outcome for breast cancer patients. A specific role of SMRT in breast cancer progression has not been elucidated, but SMRT knock-down limits estradiol-dependent growth of MCF-7 breast cancer cells. In this study, small-interfering RNA (siRNA) and short-hairpin RNA (shRNA) approaches were used to determine the effects of SMRT depletion on growth of ERα-positive MCF-7 and ZR-75–1 breast cancer ce

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45

Li, Xiao-Lei, and Jinkui Tang. "Recent developments in single-molecule toroics." Dalton Transactions 48, no. 41 (2019): 15358–70. http://dx.doi.org/10.1039/c9dt02113b.

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46

Hong, Suk-Hyun, Zhihong Yang та Martin L. Privalsky. "Arsenic Trioxide Is a Potent Inhibitor of the Interaction of SMRT Corepressor with Its Transcription Factor Partners, Including the PML-Retinoic Acid Receptor α Oncoprotein Found in Human Acute Promyelocytic Leukemia". Molecular and Cellular Biology 21, № 21 (2001): 7172–82. http://dx.doi.org/10.1128/mcb.21.21.7172-7182.2001.

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ABSTRACT The SMRT corepressor complex participates in transcriptional repression by a diverse array of vertebrate transcription factors. The ability to recruit SMRT appears to play a crucial role in leukemogenesis by the PML-retinoic acid receptor α (RARα) oncoprotein, an aberrant nuclear hormone receptor implicated in human acute promyelocytic leukemia (APL). Arsenite induces clinical remission of APL through a incompletely understood mechanism. We report here that arsenite is a potent inhibitor of the interaction of SMRT with its transcription factor partners, including PML-RARα. Arsenite op

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Kim, Hyeongmin, Chung-Lyol Lee, Seohyun Lee та ін. "Mechanically Robust Gastroretentive Drug-Delivery Systems Capable of Controlling Dissolution Behaviors of Coground β-Lapachone". Pharmaceutics 11, № 6 (2019): 271. http://dx.doi.org/10.3390/pharmaceutics11060271.

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In this study, we aimed to design a highly swellable and mechanically robust matrix tablet (SMT) as a gastroretentive drug-delivery system (GRDDS) capable of improving the dissolution behavior of β-lapachone with low aqueous solubility. For the preparation of SMTs, the cogrinding technique and freeze–thaw method were used to disperse β-lapachone in SMTs in an amorphous state and to enhance the swelling and mechanical properties of SMTs, respectively. As a result, the crystallinity of coground β-lapachone incorporated in the SMTs was found to be considerably decreased; thereby, the dissolution

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Harrison, Benjamin K., Husen Zhang, Will Berelson, and Victoria J. Orphan. "Variations in Archaeal and Bacterial Diversity Associated with the Sulfate-Methane Transition Zone in Continental Margin Sediments (Santa Barbara Basin, California)." Applied and Environmental Microbiology 75, no. 6 (2009): 1487–99. http://dx.doi.org/10.1128/aem.01812-08.

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ABSTRACT The sulfate-methane transition zone (SMTZ) is a widespread feature of continental margins, representing a diffusion-controlled interface where there is enhanced microbial activity. SMTZ microbial activity is commonly associated with the anaerobic oxidation of methane (AOM), which is carried out by syntrophic associations between sulfate-reducing bacteria and methane-oxidizing archaea. While our understanding of the microorganisms catalyzing AOM has advanced, the diversity and ecological role of the greater microbial assemblage associated with the SMTZ have not been well characterized.

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Chen, Yu-Wen, Jann-Inn Tzeng, Min-Fei Lin, Ching-Hsia Hung, and Jhi-Joung Wang. "Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Allodynia and Suppresses Spinal Substance P and Proinflammatory Cytokine Release in Rats." Physical Therapy 95, no. 1 (2015): 76–85. http://dx.doi.org/10.2522/ptj.20130306.

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BackgroundTranscutaneous electrical nerve stimulation (TENS) is often used for management of chronic pain.ObjectiveThe purpose of this study was to investigate whether TENS altered postincisional allodynia, substance P, and proinflammatory cytokines in a rat model of skin-muscle incision and retraction (SMIR).DesignThis was an experimental study.MethodsHigh-frequency (100-Hz) TENS therapy began on postoperative day 3 and was administered for 20 minutes daily to SMIR-operated rats by self-adhesive electrodes delivered to skin innervated via the ipsilateral dorsal rami of lumbar spinal nerves L1

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Murakami, Chiaki, Fumi Hoshino, Hiromichi Sakai, Yasuhiro Hayashi, Atsushi Yamashita та Fumio Sakane. "Diacylglycerol kinase δ and sphingomyelin synthase–related protein functionally interact via their sterile α motif domains". Journal of Biological Chemistry 295, № 10 (2020): 2932–47. http://dx.doi.org/10.1074/jbc.ra119.012369.

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The δ isozyme of diacylglycerol kinase (DGKδ) plays critical roles in lipid signaling by converting diacylglycerol (DG) to phosphatidic acid (PA). We previously demonstrated that DGKδ preferably phosphorylates palmitic acid (16:0)- and/or palmitoleic acid (16:1)-containing DG molecular species, but not arachidonic acid (20:4)-containing DG species, which are recognized as DGK substrates derived from phosphatidylinositol turnover, in high glucose-stimulated myoblasts. However, little is known about the origin of these DG molecular species. DGKδ and two DG-generating enzymes, sphingomyelin synth

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