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Relevant bibliographies by topics / Smudge cells

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Academic literature on the topic 'Smudge cells'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Smudge cells"

1

Nowakowski, Grzegorz S., James D. Hoyer, Tait D. Shanafelt, et al. "Percentage of Smudge Cells on Routine Blood Smear Predicts Survival in Chronic Lymphocytic Leukemia." Journal of Clinical Oncology 27, no. 11 (2009): 1844–49. http://dx.doi.org/10.1200/jco.2008.17.0795.

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PurposeSmudge cells are ruptured chronic lymphocytic leukemia (CLL) cells appearing on the blood smears of CLL patients. Our recent findings suggest that the number of smudge cells may have important biologic correlations rather than being only an artifact of slide preparation. In this study, we evaluated whether the smudge cell percentage on a blood smear predicted survival of CLL patients.Patients and MethodsWe calculated smudge cell percentages (ratio of smudged to intact cells plus smudged lymphocytes) on archived blood smears from a cohort of previously untreated patients with predominant

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Gogia, Ajay, Vinod Raina, Atul Sharma, et al. "Prognostic and predictive significance of smudge cell percentage on routine blood smear in chronic lymphocytic leukemia patients: A single center study from northern India." Journal of Clinical Oncology 30, no. 15_suppl (2012): 6593. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.6593.

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6593 Background: Smudge cells are ruptured lymphocytes seen on routine blood smears of chronic lymphocytic leukemia (CLL) patients. We evaluated prognostic and predictive significance of smudge cells percentage on a blood smear in CLL patients. Methods: We calculated smudge cell percentages (ratio of smudged to intact cells plus smudged lymphocyte) on archived blood smears of 185 untreated CLL patients registered at I.R.C.H, AIIMS, New Delhi over a period of 11 years. Results: There were 135 males and 50 females. The median age was 60 years (28-89). Median absolute lymphocyte count was 42 X109

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Nowakowski, Grzegorz S., James D. Hoyer, Tait D. Shanafelt, et al. "Smudge Cells on Routine Blood Smear Predict Clinical Outcome in Chronic Lymphocytic Leukemia: A Universally Available Prognostic Test." Blood 108, no. 11 (2006): 2785. http://dx.doi.org/10.1182/blood.v108.11.2785.2785.

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Abstract Background: The prognosis of patients with early Rai and Binet stage CLL is variable. Recently developed prognostic tests (mutation status, ZAP-70, chromosome evaluation by FISH) require significant technologic expertise and are not available worldwide to most patients with CLL. Smudge cells are ruptured CLL cells appearing on a blood smear. Using a proteomic approach, we recently discovered that the cytoskeletal protein vimentin is expressed at higher levels in CLL cells with unmutated IgVH and that vimentin expression is a marker of poor prognosis in early stage CLL (Blood, 2005;106

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Nowakowski, Grzegorz S., James D. Hoyer, Tait D. Shanafelt, et al. "Percentage of Smudge Cells on Blood Smear Predicts Prognosis in Chronic Lymphocytic Leukemia: A Multicenter Study." Blood 110, no. 11 (2007): 745. http://dx.doi.org/10.1182/blood.v110.11.745.745.

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Abstract Background: Smudge cells are ruptured CLL cells seen on blood smears of CLL patients. For over a century, smudge cells were thought to represent an artifact of slide preparation. We recently showed that smudge cell formation was inversely proportional to leukemic B cell vimentin content. Vimentin is a cytoskeletal protein critical for lymphocyte rigidity and migration; high vimentin content is related to poor prognosis in CLL. Concordantly, in an initial small cohort of patients from a single institution, we found that patients with a low (<30%) percentage of smudge cells on a bloo

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5

Szerafin, László, János Jakó, Ferenc Riskó, and Zsuzsanna Hevessy. "The prognostic value of smudge cells (Gumprecht shadows) in chronic lymphocytic leukaemia." Orvosi Hetilap 153, no. 44 (2012): 1732–37. http://dx.doi.org/10.1556/oh.2012.29477.

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Introduction: Smudge cells (Gumprecht shadows) are chronic lymphocytic leukaemic cells ruptured during peripherial blood smear preparation. It has been demonstrated to be linked to reduced expression of the cytoskeletal protein vimentin and its inverse correlation with the clinical outcome of the disease. Aims: Investigation of the percentage of smudge cells, CD38-, ZAP-70-positive cells and the time to treatment in patients with chronic lymphocytic leukaemia. Methods: Authors investigated the percentage of smudge cells, CD38- and ZAP-70-positive cells in the peripheral blood of 50 patients wi

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Sall, Abibatou, Awa Oumar Touré, Fatimata Bintou Sall, et al. "Using Smudge Cells Percentage on Routine Blood Smear in Chronic Lymphoytic Leukemia As Prognostic Factor: Senegalese Experience." Blood 126, no. 23 (2015): 5273. http://dx.doi.org/10.1182/blood.v126.23.5273.5273.

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Abstract Introduction/ Background : Chronic lymphocytic leukemia (CLL) is a heterogeneous disease which can present as an aggressive and life threatening leukemia or as an indolent form that will not require treatment for decades. This heterogeneity has important consequences which will impact on clinical approaches, treatment strategies, and survival times from diagnosis. Prognostic markers such as expression of specific proteins in or on CLL cells (ie, CD38, 70-kD ζ-associated protein or CD49d), cytogenetic abnormalities (del 13q, del 11q, del 17p and trisomy 12) quantified by FISH and immun

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Paluri, Ravikumar, Supriya Koya, Randall S. Davis, et al. "Percentage of Smudge Cells Predicting Prognosis In Chronic Lymphocytic Leukemia." Blood 116, no. 21 (2010): 4624. http://dx.doi.org/10.1182/blood.v116.21.4624.4624.

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Abstract Abstract 4624 Background: Identifying prognostic markers is important for clinical and pathological course of chronic lymphocytic leukemia. Percentage of smudge cells in CLL patients has recently been reported as a novel prognostic factor. We present here the preliminary results of the retrospective cohort study of 90 patients diagnosed with CLL at a major referral center in the state of Alabama between 1997 and 2009. Methods: Smudge cell percentage (ratio of smudge cells to combined smudge cells and intact cells) was calculated by microscopic evaluation of archived Wright-Giemsa stai

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Billett, Henny H., Kateryna Fedorov, Margarita Kushnir, David Yin, and Morayma Reyes Gil. "Neutrophil Extracellular Traps (NETs) Are a Subset of Smudge Cells Identifiable By Peripheral Smear Autoanalyzers." Blood 134, Supplement_1 (2019): 2321. http://dx.doi.org/10.1182/blood-2019-127448.

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Background. Neutrophil Extracellular Traps (NETs) are composed of extracellular decondensed chromatin networks that play an important role in immune and inflammatory response regulation. Simple and reliable identification of NETs has been challenging. Automated analyzers such as the CellaVision® Hematology Autoanalyzer identify a subset of cell-derived entities as smudge cells. We hypothesize that, in addition to the typical degenerated lymphocytes (DLs) forming smudge cells, a proportion of smudge cells as identified by the Autoanalyzer are actually NETs. Since patients with high numbers of N

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Higuchi, Toru, Ogawa Eiki, Hamashima Hiroshi, and Ito Kenta. "Smudge cells due to infectious mononucleosis." IDCases 23 (2021): e01057. http://dx.doi.org/10.1016/j.idcr.2021.e01057.

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Barouqa, Mohammad, Kenji Ikemura, Henny Billett, et al. "Neutrophilic Extracellular Traps (NETs); A Subset of Smudge Cells Identifiable by Peripheral Smear Autoanalyzers in the Rising Era of Artificial Intelligence." American Journal of Clinical Pathology 154, Supplement_1 (2020): S10—S11. http://dx.doi.org/10.1093/ajcp/aqaa137.018.

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Abstract Background Digitized microscopy such as CellaVision® technology has revolutionized the laboratory. Smudge cells, also called basket cells, are usually seen in lymphoproliferative disorders representing remnants from degenerated lymphocytes (DLs). CellaVision® classifies DLs and web-like remnants as smudge cells. The morphology of the web-like remnants is compatible with Neutrophil Extracellular Traps (NETs) where extracellular decondensed DNA chromatin network is formed as one of several neutrophilic reactions to stress. Currently, we lack clinical tests that reliably identify and qua

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Book chapters on the topic "Smudge cells"

1

Qiao, Guohui, Minglei Sun, Guanghua Zong, Fanggu Wu, Suling Huang, and Shichuan Tang. "Automatic Smudge Cell Recognition Based on Unimodal Region and Weak Edge Features." In Advances in Intelligent and Soft Computing. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-25664-6_68.

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Flemming, Dr Kelly D. "Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)." In Fifty Neurologic Cases From Mayo Clinic. Oxford University PressNew York, NY, 2004. http://dx.doi.org/10.1093/oso/9780195177442.003.0025.

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Abstract The patient initially received treatment with corticosteroids for presumed acute disseminated encephalomyelitis (ADEM). After treatment was initiated, skin biopsy results became available. Electron microscopy showed thickening of the basal lamina from deposits of granular osmophilic material (GOM), consistent with CADASIL. CADASIL is an inherited condition characterized by migraine, recurrent subcortical strokes, and dementia. The disease leads progressively to a subcortical dementia characterized by frontal lobe signs and memory loss. In addition, pseudobulbar palsy, gait disturbance

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