Log in

Relevant bibliographies by topics / Smudge cells / Journal articles

To see the other types of publications on this topic, follow the link: Smudge cells.

Journal articles on the topic 'Smudge cells'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Smudge cells.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Nowakowski, Grzegorz S., James D. Hoyer, Tait D. Shanafelt, et al. "Percentage of Smudge Cells on Routine Blood Smear Predicts Survival in Chronic Lymphocytic Leukemia." Journal of Clinical Oncology 27, no. 11 (2009): 1844–49. http://dx.doi.org/10.1200/jco.2008.17.0795.

Full text

Abstract:

PurposeSmudge cells are ruptured chronic lymphocytic leukemia (CLL) cells appearing on the blood smears of CLL patients. Our recent findings suggest that the number of smudge cells may have important biologic correlations rather than being only an artifact of slide preparation. In this study, we evaluated whether the smudge cell percentage on a blood smear predicted survival of CLL patients.Patients and MethodsWe calculated smudge cell percentages (ratio of smudged to intact cells plus smudged lymphocytes) on archived blood smears from a cohort of previously untreated patients with predominant

APA, Harvard, Vancouver, ISO, and other styles

2

Gogia, Ajay, Vinod Raina, Atul Sharma, et al. "Prognostic and predictive significance of smudge cell percentage on routine blood smear in chronic lymphocytic leukemia patients: A single center study from northern India." Journal of Clinical Oncology 30, no. 15_suppl (2012): 6593. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.6593.

Full text

Abstract:

6593 Background: Smudge cells are ruptured lymphocytes seen on routine blood smears of chronic lymphocytic leukemia (CLL) patients. We evaluated prognostic and predictive significance of smudge cells percentage on a blood smear in CLL patients. Methods: We calculated smudge cell percentages (ratio of smudged to intact cells plus smudged lymphocyte) on archived blood smears of 185 untreated CLL patients registered at I.R.C.H, AIIMS, New Delhi over a period of 11 years. Results: There were 135 males and 50 females. The median age was 60 years (28-89). Median absolute lymphocyte count was 42 X109

APA, Harvard, Vancouver, ISO, and other styles

3

Nowakowski, Grzegorz S., James D. Hoyer, Tait D. Shanafelt, et al. "Smudge Cells on Routine Blood Smear Predict Clinical Outcome in Chronic Lymphocytic Leukemia: A Universally Available Prognostic Test." Blood 108, no. 11 (2006): 2785. http://dx.doi.org/10.1182/blood.v108.11.2785.2785.

Full text

Abstract:

Abstract Background: The prognosis of patients with early Rai and Binet stage CLL is variable. Recently developed prognostic tests (mutation status, ZAP-70, chromosome evaluation by FISH) require significant technologic expertise and are not available worldwide to most patients with CLL. Smudge cells are ruptured CLL cells appearing on a blood smear. Using a proteomic approach, we recently discovered that the cytoskeletal protein vimentin is expressed at higher levels in CLL cells with unmutated IgVH and that vimentin expression is a marker of poor prognosis in early stage CLL (Blood, 2005;106

APA, Harvard, Vancouver, ISO, and other styles

4

Nowakowski, Grzegorz S., James D. Hoyer, Tait D. Shanafelt, et al. "Percentage of Smudge Cells on Blood Smear Predicts Prognosis in Chronic Lymphocytic Leukemia: A Multicenter Study." Blood 110, no. 11 (2007): 745. http://dx.doi.org/10.1182/blood.v110.11.745.745.

Full text

Abstract:

Abstract Background: Smudge cells are ruptured CLL cells seen on blood smears of CLL patients. For over a century, smudge cells were thought to represent an artifact of slide preparation. We recently showed that smudge cell formation was inversely proportional to leukemic B cell vimentin content. Vimentin is a cytoskeletal protein critical for lymphocyte rigidity and migration; high vimentin content is related to poor prognosis in CLL. Concordantly, in an initial small cohort of patients from a single institution, we found that patients with a low (<30%) percentage of smudge cells on a bloo

APA, Harvard, Vancouver, ISO, and other styles

5

Szerafin, László, János Jakó, Ferenc Riskó, and Zsuzsanna Hevessy. "The prognostic value of smudge cells (Gumprecht shadows) in chronic lymphocytic leukaemia." Orvosi Hetilap 153, no. 44 (2012): 1732–37. http://dx.doi.org/10.1556/oh.2012.29477.

Full text

Abstract:

Introduction: Smudge cells (Gumprecht shadows) are chronic lymphocytic leukaemic cells ruptured during peripherial blood smear preparation. It has been demonstrated to be linked to reduced expression of the cytoskeletal protein vimentin and its inverse correlation with the clinical outcome of the disease. Aims: Investigation of the percentage of smudge cells, CD38-, ZAP-70-positive cells and the time to treatment in patients with chronic lymphocytic leukaemia. Methods: Authors investigated the percentage of smudge cells, CD38- and ZAP-70-positive cells in the peripheral blood of 50 patients wi

APA, Harvard, Vancouver, ISO, and other styles

6

Sall, Abibatou, Awa Oumar Touré, Fatimata Bintou Sall, et al. "Using Smudge Cells Percentage on Routine Blood Smear in Chronic Lymphoytic Leukemia As Prognostic Factor: Senegalese Experience." Blood 126, no. 23 (2015): 5273. http://dx.doi.org/10.1182/blood.v126.23.5273.5273.

Full text

Abstract:

Abstract Introduction/ Background : Chronic lymphocytic leukemia (CLL) is a heterogeneous disease which can present as an aggressive and life threatening leukemia or as an indolent form that will not require treatment for decades. This heterogeneity has important consequences which will impact on clinical approaches, treatment strategies, and survival times from diagnosis. Prognostic markers such as expression of specific proteins in or on CLL cells (ie, CD38, 70-kD ζ-associated protein or CD49d), cytogenetic abnormalities (del 13q, del 11q, del 17p and trisomy 12) quantified by FISH and immun

APA, Harvard, Vancouver, ISO, and other styles

7

Paluri, Ravikumar, Supriya Koya, Randall S. Davis, et al. "Percentage of Smudge Cells Predicting Prognosis In Chronic Lymphocytic Leukemia." Blood 116, no. 21 (2010): 4624. http://dx.doi.org/10.1182/blood.v116.21.4624.4624.

Full text

Abstract:

Abstract Abstract 4624 Background: Identifying prognostic markers is important for clinical and pathological course of chronic lymphocytic leukemia. Percentage of smudge cells in CLL patients has recently been reported as a novel prognostic factor. We present here the preliminary results of the retrospective cohort study of 90 patients diagnosed with CLL at a major referral center in the state of Alabama between 1997 and 2009. Methods: Smudge cell percentage (ratio of smudge cells to combined smudge cells and intact cells) was calculated by microscopic evaluation of archived Wright-Giemsa stai

APA, Harvard, Vancouver, ISO, and other styles

8

Billett, Henny H., Kateryna Fedorov, Margarita Kushnir, David Yin, and Morayma Reyes Gil. "Neutrophil Extracellular Traps (NETs) Are a Subset of Smudge Cells Identifiable By Peripheral Smear Autoanalyzers." Blood 134, Supplement_1 (2019): 2321. http://dx.doi.org/10.1182/blood-2019-127448.

Full text

Abstract:

Background. Neutrophil Extracellular Traps (NETs) are composed of extracellular decondensed chromatin networks that play an important role in immune and inflammatory response regulation. Simple and reliable identification of NETs has been challenging. Automated analyzers such as the CellaVision® Hematology Autoanalyzer identify a subset of cell-derived entities as smudge cells. We hypothesize that, in addition to the typical degenerated lymphocytes (DLs) forming smudge cells, a proportion of smudge cells as identified by the Autoanalyzer are actually NETs. Since patients with high numbers of N

APA, Harvard, Vancouver, ISO, and other styles

9

Higuchi, Toru, Ogawa Eiki, Hamashima Hiroshi, and Ito Kenta. "Smudge cells due to infectious mononucleosis." IDCases 23 (2021): e01057. http://dx.doi.org/10.1016/j.idcr.2021.e01057.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Barouqa, Mohammad, Kenji Ikemura, Henny Billett, et al. "Neutrophilic Extracellular Traps (NETs); A Subset of Smudge Cells Identifiable by Peripheral Smear Autoanalyzers in the Rising Era of Artificial Intelligence." American Journal of Clinical Pathology 154, Supplement_1 (2020): S10—S11. http://dx.doi.org/10.1093/ajcp/aqaa137.018.

Full text

Abstract:

Abstract Background Digitized microscopy such as CellaVision® technology has revolutionized the laboratory. Smudge cells, also called basket cells, are usually seen in lymphoproliferative disorders representing remnants from degenerated lymphocytes (DLs). CellaVision® classifies DLs and web-like remnants as smudge cells. The morphology of the web-like remnants is compatible with Neutrophil Extracellular Traps (NETs) where extracellular decondensed DNA chromatin network is formed as one of several neutrophilic reactions to stress. Currently, we lack clinical tests that reliably identify and qua

APA, Harvard, Vancouver, ISO, and other styles

11

Paydas, Semra. "Smudge cells: Very old history and new conclusions." Leukemia Research 34, no. 12 (2010): 1680. http://dx.doi.org/10.1016/j.leukres.2010.06.021.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Dilip, Deepika, Siddharth Singi, Dylan C. Webb, et al. "Peripheral Blood Smear-Based Deep Learning to Predict Cancer-Associated Thrombosis." Blood 144, Supplement 1 (2024): 2626. https://doi.org/10.1182/blood-2024-202054.

Full text

Abstract:

Background: Patients with cancer have an elevated risk of developing venous thromboembolism (VTE), a common source of morbidity and mortality. Neutrophil Extracellular Traps (NET's) are thought to contribute to the hypercoagulable state of malignancy. NET's are classified as smudge cells or artifacts using the CellaVision analyzer (CellaVision, Sweden), an automated system for performing hematology laboratory differentials. New VTE biomarkers could potentially improve risk estimation for this subpopulation of patients. We hypothesized that cellular morphology of white blood cells (WBC's), espe

APA, Harvard, Vancouver, ISO, and other styles

13

Susman, David, Russell Price, and Rouslan Kotchetkov. "Lymphocytosis with Smudge Cells Is Not Equivalent to Chronic Lymphocytic Leukemia." Case Reports in Oncology 14, no. 2 (2021): 950–56. http://dx.doi.org/10.1159/000516748.

Full text

Abstract:

Chronic lymphocytic leukemia (CLL) often presents with lymphocytosis and smudge cells (SCs) on routine peripheral blood (PB) tests. In some cases, these findings are assumed to be sufficient to diagnose CLL. We present a 54-year-old male who was referred for further management of progressing CLL. At the initial presentation, he looked unwell and had diffuse lymphadenopathy and splenomegaly. Blood work showed normocytic anemia (hemoglobin 72 g/L), thrombocytopenia (platelet count 74 × 10<sup>9</sup>/L), leukocytosis (white blood cell count 135.5 × 10<sup>9</sup>/L) inclu

APA, Harvard, Vancouver, ISO, and other styles

14

Go, Ronald S. "Smudge Cells, Serum Albumin, and Prognosis in B-Cell Chronic Lymphocytic Leukemia." Journal of Clinical Oncology 27, no. 22 (2009): e44-e44. http://dx.doi.org/10.1200/jco.2009.23.8188.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Panei, Carlos Javier, Alejandra Larsen, Ester Teresa González, and María Gabriela Echeverría. "Presence of Gumprecht shadows (smudge cells) in bovine leukemia virus-positive cattle." Journal of Virological Methods 193, no. 2 (2013): 519–20. http://dx.doi.org/10.1016/j.jviromet.2013.07.022.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Jerez, Joaquín, and Daniel M. Ernst. "High percentage of smudge cells in a patient with COVID19: Rediscovering their utility." eJHaem 1, no. 1 (2020): 374–75. http://dx.doi.org/10.1002/jha2.52.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Porimal Mollik. "Segmentation White Blood Cells by Machine Learning Algorithms." World Journal of Biology Pharmacy and Health Sciences 13, no. 2 (2023): 009–14. http://dx.doi.org/10.30574/wjbphs.2023.13.2.0159.

Full text

Abstract:

Blood and its elements have a vital position in human life and are the best indicator for deciding many pathological states. Specifically, white blood cells are of great significance for diagnosing hematological disorders. In this analysis, 350 microscopic blood smudge images have experimented with six machine learning algorithms for the sort of white blood cells, and their renditions have resembled. Thirty-five distinct geometric and statistical (consistency) features have been pulled from blood pictures for practicum and test parameters of machine learning algorithms. According to the outcom

APA, Harvard, Vancouver, ISO, and other styles

18

Porimal, Mollik. "Segmentation White Blood Cells by Machine Learning Algorithms." World Journal of Biology Pharmacy and Health Sciences 13, no. 2 (2023): 009–14. https://doi.org/10.5281/zenodo.7948500.

Full text

Abstract:

Blood and its elements have a vital position in human life and are the best indicator for deciding many pathological states. Specifically, white blood cells are of great significance for diagnosing hematological disorders. In this analysis, 350 microscopic blood smudge images have experimented with six machine learning algorithms for the sort of white blood cells, and their renditions have resembled. Thirty-five distinct geometric and statistical (consistency) features have been pulled from blood pictures for practicum and test parameters of machine learning algorithms. According to the outcom

APA, Harvard, Vancouver, ISO, and other styles

19

Yun, Hyun Don, and Edmund K. Waller. "Smudge cells following treatment with pentostatin in a patient with B-cell prolymphocytic leukemia." Blood 122, no. 4 (2013): 474. http://dx.doi.org/10.1182/blood-2013-02-481697.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Webb, Dylan C., Cesar Colorado-Jimenez, Maly Fenelus, et al. "Deep Learning-Driven 24-Hour Mortality Risk Assessment through Peripheral Blood Smear Morphology in Hospitalized Cancer Patients." Blood 144, Supplement 1 (2024): 4992. https://doi.org/10.1182/blood-2024-208716.

Full text

Abstract:

Introduction: Mortality in cancer pateints is often preceded by catastrophic hematologic and inflammatory syndromes such as the systemic inflammatory response syndrome/sepsis, disseminated intravascular coagulation (DIC), microangiopathic hemolytic anemia, hemophagocytic lymphohistiocytosis, and cytokine release syndrome. These conditions alter peripheral blood cells, causing changes in the morphology of red blood cells (RBC), white blood cells (WBC) and platelets in peripheral blood smears (PBS). We hypothesize that attention-based deep learning models using PBS feature embeddings can predict

APA, Harvard, Vancouver, ISO, and other styles

21

Macdonald, Denis, Harold Richardson, and Anne Raby. "Practice Guidelines on the Reporting of Smudge Cells in the White Blood Cell Differential Count." Archives of Pathology & Laboratory Medicine 127, no. 1 (2003): 105. http://dx.doi.org/10.5858/2003-127-105-pgotro.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Chang, Chih-Chun, Jen-Tang Sun, Tse-Hsuan Liou, et al. "Clinical Significance of Smudge Cells in Peripheral Blood Smears in Hematological Malignancies and Other Diseases." Asian Pacific Journal of Cancer Prevention 17, no. 4 (2016): 1847–50. http://dx.doi.org/10.7314/apjcp.2016.17.4.1847.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Silveira, Júlia Meireles da Silva, Sheila de Oliveira Medeiros, Renata Fernandes Ferreira de Moraes, et al. "Cytomorphological similarities between feline viral leukemia, bovine enzootic leukosis and adult T-cell leukemia/lymphoma: A review." Research, Society and Development 10, no. 9 (2021): e13010917900. http://dx.doi.org/10.33448/rsd-v10i9.17900.

Full text

Abstract:

Leukemias are malignant neoplasms of hematological origin and originating from bone marrow cells. Innumerable species can be affected by this disease, which can be originated by several causes, including infection by viruses belonging to the Retroviridae family. In felines, humans and cattle, the leukemia-inducing retroviruses are Feline Leukemia Virus (FeLV), human T-cell lymphotropic virus type 1 (HTLV-1) and Bovine Leukosis Virus (BLV), respectively. In Brazil, the number of domestic cats infected with FeLV grows progressively, when compared to the incidence of infected animals in developed

APA, Harvard, Vancouver, ISO, and other styles

24

Verma Saluja, Komal, Yajesh Arya, Deepti Sukheeja, and Chetan Prakash Suman. "Spontaneous tumour lysis syndrome in chronic lymphocytic leukaemia: an unanticipated complication of an undiagnosed disease." BMJ Case Reports 17, no. 11 (2024): e261320. http://dx.doi.org/10.1136/bcr-2024-261320.

Full text

Abstract:

Spontaneous tumour lysis syndrome (STLS) is a rare oncological emergency characterised by the spontaneous destruction of tumour cells in the absence of chemotherapy, with the release of large amounts of intracellular ions and metabolic products leading to organ damage and at times death. In chronic lymphocytic leukaemia (CLL), historically, tumour lysis syndrome has been rarely observed owing to low rate of proliferation and slow response to chemotherapy. We report a rare case of STLS in underlying undiagnosed CLL. A man in his 60s presented with vomiting, diarrhoea, breathlessness on exertion

APA, Harvard, Vancouver, ISO, and other styles

25

Sahreni, Rahmi, and Irza Wahid. "Leukemia Limfositik Kronik pada Limfoma Non Hodgkin." Jurnal Kesehatan Andalas 8, no. 1S (2019): 84. http://dx.doi.org/10.25077/jka.v8i1s.933.

Full text

Abstract:

Leukemia Limfositik Kronik (LLK) adalah suatu keganasan hematologik yang ditandai oleh proliferasi klonal dan penumpukan limfosit B neoplastik dalam darah. Limfoma Non Hodgkin (LNH) adalah kelompok keganasan primer limfosit B, limfosit T jarang berasal dari sel NK (natural killer). Keduanya merupakan keganasan hematologi yang berasal dari limfosit B. Transformasi LNH menjadi LLK sangat jarang terjadi. Telah dilaporkan perempuan 38 tahun dengan keluhan utama benjolan di leher muncul kembali sejak 1 bulan yang lalu setelah kemoterapi LNH dengan regimen Cyclophosfamide, Doxorubicine, Vincristine

APA, Harvard, Vancouver, ISO, and other styles

26

Johansson, P., L. Eisele, L. Klein-Hitpass, et al. "Percentage of smudge cells determined on routine blood smears is a novel prognostic factor in chronic lymphocytic leukemia." Leukemia Research 34, no. 7 (2010): 892–98. http://dx.doi.org/10.1016/j.leukres.2010.02.038.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Motoa, Gabriel, Harry Ross Powers, and Lisa M. Brumble. "Disseminated cryptococcosis in a patient with newly diagnosed HTLV-1 infection." BMJ Case Reports 14, no. 1 (2021): e235794. http://dx.doi.org/10.1136/bcr-2020-235794.

Full text

Abstract:

Infection by human T-lymphotropic virus 1 (HTLV-1) is often seen as the cause of chronic infection or lymphoproliferative disorders, but many clinicians do not recognise its association with severe immunosuppression. We report the case of a woman in her 70s from the Caribbean who sought care at the emergency department for weakness, fatigue and weight loss. Further work-up showed atypical lymphocytosis with floral lymphocytes and smudge cells in the peripheral blood smear and hypercalcaemia. Chest CT demonstrated a moderate right pleural effusion. Results of HIV testing were negative, and scre

APA, Harvard, Vancouver, ISO, and other styles

28

Matos, Daniel M., Guilherme Perini, Carlos Kruzich, Eduardo M. Rego, and Roberto P. Falcão. "Smudge cells in peripheral blood smears did not differentiate chronic lymphocytic leukemia from other B-cell chronic lymphoprolipherative diseases." Revista Brasileira de Hematologia e Hemoterapia 31, no. 5 (2009): 333–36. http://dx.doi.org/10.1590/s1516-84842009005000069.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Yonal, Ipek, Esra Nazlıgul, Gulsum Tas, Mehmet Ramazan Agan, Mustafa Nuri Yenerel, and Meliha Nalcaci. "A case of chronic lymphocytic leukemia with massive ascites." Rare Tumors 4, no. 4 (2012): 165–68. http://dx.doi.org/10.4081/rt.2012.e51.

Full text

Abstract:

An 81-year old woman with a history of chronic lymphocytic leukemia (CLL) was admitted with night sweats and abdominal distension. A complete blood count showed hemoglobin 5 g/dL, white blood cell (WBC) count 28.5×109/L and platelets 38.4×109/L. Peripheral blood smear examination showed a large number of smudge cells and lymphocytosis composed of mature-looking lymphocytes with clumped nuclear chromatin. Computed tomography scan demonstrated enlarged cervical, axillary, paraaortic, retroperitoneal and mesenteric lymph nodes with concomitant omental thickening and ascites. Also, the liver and t

APA, Harvard, Vancouver, ISO, and other styles

30

Nowakowski, Grzegorz S., James D. Hoyer, Tait D. Shanafelt, et al. "Using Smudge Cells on Routine Blood Smears to Predict Clinical Outcome in Chronic Lymphocytic Leukemia: A Universally Available Prognostic Test." Mayo Clinic Proceedings 82, no. 4 (2007): 449–53. http://dx.doi.org/10.4065/82.4.449.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Bissell, M. G. "Using Smudge Cells on Routine Blood Smears to Predict Clinical Outcome in Chronic Lymphocytic Leukemia: A Universally Available Prognostic Test." Yearbook of Pathology and Laboratory Medicine 2008 (January 2008): 365–66. http://dx.doi.org/10.1016/s1077-9108(08)70762-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

White, Robert A., Steven G. McNulty, Shelly Roman, et al. "Chromosomal localization, hematologic characterization, and iron metabolism of the hereditary erythroblastic anemia (hea) mutant mouse." Blood 104, no. 5 (2004): 1511–18. http://dx.doi.org/10.1182/blood-2004-01-0076.

Full text

Abstract:

Abstract Understanding iron metabolism has been enhanced by identification of genes for iron deficiency mouse mutants. We characterized the genetics and iron metabolism of the severe anemia mutant hea (hereditary erythroblastic anemia), which is lethal at 5 to 7 days. The hea mutation results in reduced red blood cell number, hematocrit, and hemoglobin. The hea mice also have elevated Zn protoporphyrin and serum iron. Blood smears from hea mice are abnormal with elevated numbers of smudge cells. Aspects of the hea anemia can be transferred by hematopoietic stem cell transplantation. Neonatal h

APA, Harvard, Vancouver, ISO, and other styles

33

Doan, Phuong L., J. Lauren Russell, Sarah K. Meadows, et al. "Deletion of Bak and Bax in Tie2+ BM Hematopoietic Stem Cells Induces a B Cell Lymphoproliferative Disorder." Blood 114, no. 22 (2009): 1247. http://dx.doi.org/10.1182/blood.v114.22.1247.1247.

Full text

Abstract:

Abstract Abstract 1247 Poster Board I-269 Chronic lymphocytic leukemia (CLL) is characterized by a monoclonal, mature B-cell lymphocytosis, lymphadenopathy and splenomegaly. The pathogenesis of CLL is thought to be related to abnormal programmed cell death mechanisms but the precise contribution of several pro-apoptotic genes remains unknown. Elucidation of the pathogenesis of CLL is also limited by the lack of animal models which reproduce the CLL phenotype. We present a transgenic mouse model in which conditional, tissue-specific deletion of Bax is achieved in Tie2+ hematopoietic stem cells

APA, Harvard, Vancouver, ISO, and other styles

34

Brigden, Malcolm L., Sandra Au, Susan Thompson, Sean Brigden, Patrick Doyle, and Yotis Tsaparas. "Infectious Mononucleosis in an Outpatient Population." Archives of Pathology & Laboratory Medicine 123, no. 10 (1999): 875–81. http://dx.doi.org/10.5858/1999-123-0875-imiaop.

Full text

Abstract:

Abstract Objectives.—To determine the sensitivity and specificity of 2 modern hematology analyzers in flagging heterophile-positive patients; to determine if heterophile-positive, instrument-flagged specimens contain a larger number or a different spectrum of atypical lymphocytes; to document the overall sensitivity and specificity of Hoagland's morphologic criteria in identifying heterophile-positive patients in an outpatient population with a clinical diagnosis of mononucleosis; and to examine whether individual morphologic features might aid in the diagnosis of suspected infectious mononucl

APA, Harvard, Vancouver, ISO, and other styles

35

Fedorov, Kateryna, Mohammad Barouqa, David Yin, Margarita Kushnir, Henny H. Billett, and Morayma Reyes Gil. "Identifying Neutrophil Extracellular Traps (NETs) in Blood Samples Using Peripheral Smear Autoanalyzers." Life 13, no. 3 (2023): 623. http://dx.doi.org/10.3390/life13030623.

Full text

Abstract:

Neutrophil Extracellular Traps (NETs) are large neutrophil-derived structures composed of decondensed chromatin, cytosolic, and granule proteins. NETs play an important role in fighting infection, inflammation, thrombosis, and tumor progression processes, yet their fast and reliable identification has been challenging. Smudge cells (SCs) are a subcategory of white cells identified by CellaVision®, a hematology autoanalyzer routinely used in clinical practice that uses digital imaging to generate “manual” differentials of peripheral blood smears. We hypothesize that a proportion of cells identi

APA, Harvard, Vancouver, ISO, and other styles

36

Rendra, Muthia, Rismawati Yaswir, and Akmal M. Hanif. "Gambaran Laboratorium Leukemia Kronik di Bagian Penyakit Dalam RSUP Dr. M. Djamil Padang." Jurnal Kesehatan Andalas 2, no. 3 (2013): 141. http://dx.doi.org/10.25077/jka.v2i3.153.

Full text

Abstract:

AbstrakLeukemia merupakan penyakit keganasan sel darah yang berasal dari sumsum tulang ditandai oleh proliferasi sel-sel darah putih, dengan manifestasi adanya sel-sel abnormal dalam darah tepi. Pada tahun 2006, leukemia berada pada urutan ke-5 dari keseluruhan penderita kanker di Indonesia. Leukemia kronik merupakan leukemia yang paling sering terjadi pada dewasa dan lanjut usia. Secara umum leukemia kronik diklasifikasikan atas Leukemia Granulositik Kronik (LGK) dan Leukemia Limfositik Kronik (LLK). Leukemia kronik yang perjalanannya lambat dan diiringi oleh gejala yang tidak khas, maka pene

APA, Harvard, Vancouver, ISO, and other styles

37

Paul, Ronald, Lidice L. Lopez, Diana B. Careaga, Oilda Rubio, and Ravindra Mylvaganam. "Conservative Whole Blood Extended Differential Method." Blood 110, no. 11 (2007): 3846. http://dx.doi.org/10.1182/blood.v110.11.3846.3846.

Full text

Abstract:

Abstract The neutrophilic precursors (excluding bands), blast cells and erythroblasts normally reside in the bone marrow. The presence of any of these precursors as well as atypical/variant lymphocytes in peripheral blood is indicative of a diseased or disordered state. Therefore, it is of clinical importance to identify and enumerate these atypical cell populations. In general, commercial hematology systems do not have the ability to enumerate all of the nucleated atypical cells that are traditionally identified by manual differential. However, the manual differential is labor intensive and c

APA, Harvard, Vancouver, ISO, and other styles

38

Tayyib,, Nahla, Mabrouk Abo-Zaid, Ahmed Ismail, Soha Mohammed, and Ali Amin. "COVID-19 Case Report: Circulating blood cells morphology in convalescent patient." Journal of Umm Al-Qura University for Medical Sciences 8, no. 2 (2022): 25–28. http://dx.doi.org/10.54940/ms38961714.

Full text

Abstract:

Objective: Many studies have detailed the mechanisms of infection and quantitative peripheral blood findings reported in severe acute respiratory syndrome virus 2 (SARS-CoV-2) patients during the severity of infection since the start of the coronavirus disease 2019 (COVID-19) pandemic. Though, only a few studies have described blood morphologic abnormalities. We report peripheral blood cells morphologic changes in convalescent patient. Design: We performed complete blood counts (CBC), and blood smear of 52-year-old patient who were COVID-19 positive test by (RT-PCR), from May 20, 2021, through

APA, Harvard, Vancouver, ISO, and other styles

39

Agustinus Sigit Pamungkas and Enny. "Unmasking Occult Malignancy: The Pivotal Role of the Peripheral Blood Smear in the Initial Diagnosis of Chronic Lymphocytic Leukemia." Bioscientia Medicina : Journal of Biomedicine and Translational Research 9, no. 8 (2025): 8431–41. https://doi.org/10.37275/bsm.v9i8.1363.

Full text

Abstract:

Background: Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy in adults, frequently discovered incidentally through routine blood tests due to its often nonspecific clinical presentation. In resource-limited settings, fundamental laboratory investigations are crucial for initiating the diagnostic pathway. This report illustrates the critical diagnostic value of the complete blood count and peripheral blood smear in identifying CLL in a patient presenting with vague constitutional symptoms. Case presentation: A 43-year-old female with a history of type 2 diabetes mellitus pr

APA, Harvard, Vancouver, ISO, and other styles

40

Lazim, A., and R. Kuklani. "Sclerosing Epithelioid Fibrosarcoma; A Case report and review of literature." American Journal of Clinical Pathology 156, Supplement_1 (2021): S89. http://dx.doi.org/10.1093/ajcp/aqab191.189.

Full text

Abstract:

Abstract Introduction/Objective Sclerosing Epithelioid Fibrosarcoma (SEF) is an unusual, rare clinically aggressive form of soft tissue sarcoma. It is characterized by a slow evolution, with local recurrences and late metastases that are mainly pulmonary and pleural in about 80% of cases. SEF has distinctive morphology and occurs most commonly in deep soft tissue of adult extremities. Lesions involving the head and neck region are uncommon and rare intraosseously in oral cavity. Methods/Case Report Herein we report a case of a 52-year-old male who presented with a symptomatic radiolucent lesio

APA, Harvard, Vancouver, ISO, and other styles

41

Gulati, Gene, Vandi Ly, Guldeep Uppal, and Jerald Gong. "Feasibility of Counting Smudge Cells as Lymphocytes in Differential Leukocyte Counts Performed on Blood Smears of Patients With Established or Suspected Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma." Laboratory Medicine 48, no. 2 (2017): 137–47. http://dx.doi.org/10.1093/labmed/lmx002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Sun, Xiaoping, Amaris Shi, Jinchun Matthew Liu, Jeffrey Liu, Yun Gong, and Zhihong Hu. "Abstract B031: Artificial Intelligence-Enhanced Image Analysis of Peripheral Blood Smears Supports the Diagnosis and Monitoring of Acute Promyelocytic Leukemia." Clinical Cancer Research 31, no. 13_Supplement (2025): B031. https://doi.org/10.1158/1557-3265.aimachine-b031.

Full text

Abstract:

Abstract Acute promyelocytic leukemia (APL) is a high-risk leukemia requiring prompt diagnosis and treatment to reduce early mortality. Peripheral blood (PB) smears often provide excellent monolayer morphology, offering diagnostic information comparable to bone marrow aspirate smears. CellaVision, an automated imaging system widely used in hematology laboratories, enables automated classification of blood cells and generates high-resolution images to support accurate morphological assessment. To enhance early detection and precise monitoring of APL from PB smears, we developed a “MDA-LeukoLens

APA, Harvard, Vancouver, ISO, and other styles

43

Adami, Dante, Sebastian Riechert, Tim Schmittmann, et al. "Autonomous Region-of-Interest Detection, Cell Segmentation and Cell Classification in Bone Marrow Cytomorphology Using Deep Learning." Blood 144, Supplement 1 (2024): 4975. https://doi.org/10.1182/blood-2024-205235.

Full text

Abstract:

The differential nucleated cell count in bone marrow smears forms the diagnostic basis in hematological disorders. The current gold standard involves manually detecting evaluable regions of interest (ROI) and subjectively categorizing up to 500 cells to form a diagnosis. This process is time-consuming, labor-intensive, and suffers from high inter-observer variability. To address this issue, we propose an end-to-end deep learning pipeline for automating cytomorphology in bone marrow smears, covering ROI selection in whole slide images (WSI), cell detection and classification of 20 cell types. R

APA, Harvard, Vancouver, ISO, and other styles

44

Azadi, Amir, Padmini Moffett, Mounika Mandadi, and Goetz H. Kloecker. "a Rare Case of Chronic Lymphocytic Leukemia (CLL), Transforming to Two Different Types of Aggressive Lymphoma during the Course of the Disease." Blood 124, no. 21 (2014): 5650. http://dx.doi.org/10.1182/blood.v124.21.5650.5650.

Full text

Abstract:

Abstract A rare case of chronic lymphocytic leukemia (CLL), Transforming to two different types of aggressive lymphoma during the course of the disease. BACKGROUND Patients with chronic lymphocytic leukemia may have disease transformation to non-Hodgkin's lymphoma (DLBL)or prolymphocytic leukemia (PLL) To date there have been no cases in the english literatures reporting a CLL patient presenting with transformation to both of these different types of more aggressive diseases during the course of their disease. We describe a rare case of CLL who developed transformation to PLL and DLBL, also kn

APA, Harvard, Vancouver, ISO, and other styles

45

Haferlach, Torsten, Christian Pohlkamp, Inseok Heo, et al. "Automated Peripheral Blood Cell Differentiation Using Artificial Intelligence - a Study with More Than 10,000 Routine Samples in a Specialized Leukemia Laboratory." Blood 138, Supplement 1 (2021): 103. http://dx.doi.org/10.1182/blood-2021-152447.

Full text

Abstract:

Abstract Background: Cytomorphology is the gold standard for quick assessment of peripheral blood (PB) and bone marrow samples in hematological neoplasms and is used to orchestrate specific diagnostics. Artificial Intelligence (AI) promises to provide an unbiased way of interrogating blood smear data as reproducibility varies across labs. This is a prospective clinical study (ClinicalTrials.gov Identifier: NCT04466059) conducted on our approach outlined at ASH 2020. Aim: Use an AI model to classify cell images to produce differential counts of PB smears side-by-side to routine diagnostics. Met

APA, Harvard, Vancouver, ISO, and other styles

46

Haridas, Keerthana, and Nirali Shah. "ODP564 Hypercalcemia in the Setting of HTLV-1 Infection and Normal PTHrP Levels." Journal of the Endocrine Society 6, Supplement_1 (2022): A183—A184. http://dx.doi.org/10.1210/jendso/bvac150.378.

Full text

Abstract:

Abstract A 53 year old male with history of HTLV-1 infection associated myelopathy but with unknown mode of transmission, presented with acute on chronic bilateral lower extremity weakness and numbness with no other deficits. Examination revealed decreased strength (grade 1/5) in lower extremities with normal bulk, tone and sensations. Initial blood work revealed hypercalcemia with corrected Calcium of 16.2mg/dl(8.5-11.5), Phosphorus of 2.7mg/dl (2.5- 4.5) and Alkaline Phosphatase of 126mg/dl(20-140). Workup for hypercalcemia revealed Parathyroid hormone (PTH) level of 14pg/ml (10-65), 25 hydr

APA, Harvard, Vancouver, ISO, and other styles

47

Oo, Thein H., and Neela Natarajan. "Rituximab Is Effective in Refractory Adult Immune Thrombocytopenic Purpura Associated with Chronic Lymphocytic Leukemia." Blood 104, no. 11 (2004): 3952. http://dx.doi.org/10.1182/blood.v104.11.3952.3952.

Full text

Abstract:

Abstract Chronic lymphocytic leukemia ( CLL ) is the commonest leukemia in the western world. 2% of CLL patients present with immune thrombocytopenic purpura ( ITP ). Corticosteroids, intravenous immune globulins ( IVIG ) and splenectomy have been the mainstay of treatment of ITP. Rituximab is the monoclonal antibody against CD-20 antigen expressed on the B-lymphocytes. It has established its role in the treatment of many B-cell malignancies in the last one decade. Due to its B-cell depletion capability, interests in employing rituximab in the treatment of many autoimmune diseases have grown i

APA, Harvard, Vancouver, ISO, and other styles

48

Stepien, Karolina, Franek Sierpowski, Zsombor Prucsi, et al. "Abstract 2066: Measuring the activity of SMUG1 DNA glycosylase with a novel sSTRIDE-SMUG1 assay." Cancer Research 84, no. 6_Supplement (2024): 2066. http://dx.doi.org/10.1158/1538-7445.am2024-2066.

Full text

Abstract:

Abstract On average, spontaneous deamination of cytosine to aberrant base uracil happens 70-200 times per human genome per day. These mutagenic U/G mispairs are, however, corrected by error-free base repair (BER) initiated by uracil-DNA glycosylases. SMUG1 (single-strand selective monofunctional uracil DNA glycosylase), as one of the major glycosylases, removes uracil and oxidized pyrimidines from DNA. In spite of the name, SMUG1 removes uracil also from double-stranded DNA. Unrepaired by SMUG1 U/G mispairs are mutagenic, and alterations in SMUG1 expression levels have been linked to cancer de

APA, Harvard, Vancouver, ISO, and other styles

49

An, Mi-Jin, Geun-Seup Shin, Hyun-Min Lee, and Jung-Woong Kim. "Ablation of SMUG1 Reduces Cell Viability and Increases UVC-Mediated Apoptosis in Hepatocarcinoma HepG2 Cells." Genes 12, no. 2 (2021): 201. http://dx.doi.org/10.3390/genes12020201.

Full text

Abstract:

Uracil is an unavoidable aberrant base in DNA sequences, the repair of which takes place by a highly efficient base excision repair mechanism. The removal of uracil from the genome requires multiple biochemical steps with conformational changes of DNA that inhibit DNA replication and interfere with transcription. However, the relevance of uracil in DNA for cellular physiology and transcriptional regulation is not fully understood. We investigated the functional roles of SMUG1 using knock-down (KD) and knock-out (KO) models. The proliferation ratio of SMUG1 KD and KO cells was decreased compare

APA, Harvard, Vancouver, ISO, and other styles

50

McPherson, Lisa A., Yixuan Gao, Shanthi Adimoolam, et al. "Abstract 4777: A small-molecule SMUG1 activator enhances repair of 5-hydroxymethyl-2’-deoxyuridine-mediated pyrimidine lesions in DNA." Cancer Research 84, no. 6_Supplement (2024): 4777. http://dx.doi.org/10.1158/1538-7445.am2024-4777.

Full text

Abstract:

Abstract Background: Pharmacological upregulation of DNA repair pathways presents a potentially promising approach for cancer prevention in populations that are genetically high-risk. SMUG1, an enzyme involved in base excision repair, removes uracil and certain oxidized bases from DNA to mitigate adverse genotoxic and mutagenic effects and represents a promising target for cancer therapy. A growing body of evidence suggests that SMUG1 is involved in tumorigenesis, and deficiency of SMUG1 correlates with poor prognosis in several cancers. We hypothesize that upregulation of SMUG1 by a small mol

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!