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Deng, Xin Jie, Yang Sheng You, Yan Ying Chen, and Xue Mei Yang. "The Application of the Smirnov Test in the Homogeneity Test for Non-Normal Distribution Temperature Series." Advanced Materials Research 516-517 (May 2012): 530–35. http://dx.doi.org/10.4028/www.scientific.net/amr.516-517.530.
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The homogeneity test is the first stage to revise the climate records. Its accuracy will directly affect the follow-up work. The classic method SNHT (Standard Normal Homogeneity Test) can only be applied in climatic sequences obey normal distribution, but lots of non-normality climate sequences need to be examined. In this paper, the Smirnov Test was introduced to test the homogeneity of the temperature series, which is a classical method for distribution test, and it can apply for the temperature sequences obey any distribution. The homogeneity test results by testing Chongqing Municipality's temperature sequences show that: the Smirnov Test is better than SNHT
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Wang, Xiaolan L., Qiuzi H. Wen, and Yuehua Wu. "Penalized Maximal t Test for Detecting Undocumented Mean Change in Climate Data Series." Journal of Applied Meteorology and Climatology 46, no. 6 (2007): 916–31. http://dx.doi.org/10.1175/jam2504.1.
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Abstract In this paper, a penalized maximal t test (PMT) is proposed for detecting undocumented mean shifts in climate data series. PMT takes the relative position of each candidate changepoint into account, to diminish the effect of unequal sample sizes on the power of detection. Monte Carlo simulation studies are conducted to evaluate the performance of PMT, in comparison with the most popularly used method, the standard normal homogeneity test (SNHT). An application of the two methods to atmospheric pressure series recorded at a Canadian site is also presented. It is shown that the false-alarm rate of PMT is very close to the specified level of significance and is evenly distributed across all candidate changepoints, whereas that of SNHT can be up to 10 times the specified level for points near the ends of series and much lower for the middle points. In comparison with SNHT, therefore, PMT has higher power for detecting all changepoints that are not too close to the ends of series and lower power for detecting changepoints that are near the ends of series. On average, however, PMT has significantly higher power of detection. The smaller the shift magnitude Δ is relative to the noise standard deviation σ, the greater is the improvement of PMT over SNHT. The improvement in hit rate can be as much as 14%–25% for detecting small shifts (Δ < σ) regardless of time series length and up to 5% for detecting medium shifts (Δ = σ–1.5σ) in time series of length N < 100. For all detectable shift sizes, the largest improvement is always obtained when N < 100, which is of great practical importance, because most annual climate data series are of length N < 100.
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Moschas, Fanis, and Eva Steirou. "Statistical Estimation of Changes in the Dominant Frequencies of Structures in Long Noisy Series of Monitoring Data." Mathematical Problems in Engineering 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/216860.
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Damage in structures is reflected in permanent changes of their natural frequencies and theoretically can be derived through measurements. Still, measurement-derived frequencies of structures usually reflect a superimposition of various effects, fluctuations due to environmental and loading conditions, noise, and possible permanent changes (damage or repair). The amplitude of the latter is usually of the same order of magnitude with the other effects; hence permanent shifts are masked by noise and cannot be identified, especially in long monitoring records. In order to overcome this problem, essential for the assessment of the structural health of various key structures, we adopt a statistical approach developed for the identification of shifts (inhomogeneities) in normally distributed climatological data, in particular the SNHT test. The efficiency of the SNHT was first tested on synthetic data and then on sets of estimates of dominant frequencies of a decaying pedestrian bridge. It was found that under certain conditions the SNHT can identify the location of shifts in dominant frequencies of structures; the amplitude of the shifts can then be easily computed. Since the efficiency of the test increases with the length of the time series, this test seems especially suitable for the analysis of long monitoring records.
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Khaliq, M. N., and T. B. M. J. Ouarda. "On the critical values of the standard normal homogeneity test (SNHT)." International Journal of Climatology 27, no. 5 (2007): 681–87. http://dx.doi.org/10.1002/joc.1438.
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Wanderley, Henderson Silva, André Luiz de Carvalho, Ronabson Cardoso Fernandes, and José Leonaldo de Souza. "Mudança no Regime Temporal da Temperatura do Ar e Precipitação Pluviométrica na Região de Rio Largo, Alagoas (Change in the Temporal Regime of Air Temperature and Rainfall in the Region of Rio Largo, Alagoas, Brazil)." Revista Brasileira de Geografia Física 7, no. 4 (2014): 662. http://dx.doi.org/10.26848/rbgf.v7.4.p662-667.
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Compreender como as alterações no clima têm modificado a temperatura do ar e a precipitação pluvial de uma região é essencial, sobretudo para regiões como o Nordeste brasileiro, que apresentam vasto histórico de secas e altas temperaturas. No entanto, estudos com esse fim são escassos ou até mesmo inexistentes para essa região. Deste modo, objetivou-se identificar mudanças ocorridas no regime temporal da temperatura diurna e noturna e na precipitação na região de Rio Largo, Alagoas. Para isto, utilizaram-se dados de temperatura diurna (máxima) e noturna (mínima) compreendidos entre 1973 e 2002, e de precipitação dispostos entre 1973 e 2008. As séries temporais foram submetidas ao teste estatístico SNHT (Standard Normal Homogeneity Test) para identificar possíveis pontos de mudança na média. A análise de regressão linear simples foi utilizada para identificar alterações nas séries temporais, testada por meio do teste t de Student, adotando-se nível de significância estatística de 0,05%, para ambos os testes estatísticos. A análise mostrou que as temperaturas demostraram pontos de mudanças significativos, no entanto, foi observada uma defasagem de quase dez anos entre os pontos. A tendência identificada entre as temperaturas foram opostas entre si, sendo de aumento para a temperatura diurna e de redução para a noturna. A precipitação demostrou tendência de redução, no entanto, não apresentou mudança estatística significativa. ABSTRACTUnderstanding how changes in climate have changed air temperature and rainfall in a region is essential, especially for regions such as the Brazilian Northeast, which have long history of drought and high temperatures. However, studies for this purpose are scarce or even nonexistent for this region. Thus, this study aimed to identify changes in the temporal regime of daytime and nighttime temperature and rainfall in the region of Rio Largo, Alagoas, Brazil. For this, it was used data of daytime temperature (maximum) and night (minimum) ranging from 1973 to 2002, and rainfall arranged between 1973 and 2008. Time series were submitted to SNHT (Standard Normal Homogeneity Test) statistical test to identify possible change point in average. A simple linear regression analysis was used to identify changes in time series, tested using the Student t test, adopting a significance level of 0.05%, for both statistical tests. The analysis showed that temperatures demonstrated significant change points, however, there was a gap of almost ten years between the points. The trend identified among the temperatures was opposed to each other, with increasing daytime temperature and reduction of nighttime temperature. Rainfall demonstrated trend of reducing, however, showed no statistically significant change.Keywords: daytime and nighttime temperature, SNHT, trend, change point.
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Gjelten, Herdis M., Øyvind Nordli, Arne A. Grimenes, and Elin Lundstad. "The Ås Temperature Series in Southern Norway–Homogeneity Testing And Climate Analysis." Bulletin of Geography. Physical Geography Series 7, no. 1 (2014): 7–26. http://dx.doi.org/10.2478/bgeo-2014-0001.
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Abstract Homogeneity is important when analyzing climatic long-term time series. This is to ensure that the variability in the time series is not affected by changes such as station relocations, instrumentation changes and changes in the surroundings. The subject of this study is a long-term temperature series from the Norwegian University of Life Sciences at Ås in Southern Norway, located in a rural area about 30 km south of Oslo. Different methods for calculation of monthly mean temperature were studied and new monthly means were calculated before the homogeneity testing was performed. The statistical method used for the testing was the Standard Normal Homogeneity Test (SNHT) by Hans Alexandersson. Five breaks caused by relocations and changes in instrumentation were identified. The seasonal adjustments of the breaks lay between -0.4°C and +0.5°C. Comparison with two other homogenized temperature series in the Oslo fjord region showed similar linear trends, which suggests that the long-term linear temperature trends in the Oslo fjord region are not much affected by spatial climate variation.
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Agbonaye, A. I., and O. C. Izinyon. "Evaluating the Quality of Spatial Data for the Analysis of Climate Variability in the Coastal Region of Nigeria." March 2021 5, no. 1 (2021): 76–90. http://dx.doi.org/10.36263/nijest.2021.01.0236.
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The lack of truly reliable data for climate change analyses and prediction presents challenges in climate modeling. Needed data are required to be hydrologically/statistically reliable to be useful for hydrological, meteorological, climate change, and estimation studies. Thus, data quality and homogeneity screening are preliminary analyses. In this study, the homogeneity of the climatic data used for analyses of climate variability was conducted in the coastal region of Nigeria. Climatic Research Unit (CRU 0.5× 0.5) gridded monthly climatic data for sixty years (1956- 2016) for nine states of the coastal region of Nigeria obtained from internet sources were validated with the Nigerian Meteorological Agency (NiMet) data to assure adequacy for use. The data were tested for normality using the Shapiro-Wilk (S-W) test, D’Agostino-Pearson omnibus test, and skewness test. Four homogeneity test methods were applied to 257 locations in the nine states of the coastal region of Nigeria and they include Pettit’s, Standard Normal Homogeneity Test (SNHT), Buishand’s and Von Neumann Ratio (VNR) tests. The results of the validity analysis indicated that the CRU data are very reliable and thus justified their use for the further analysis carried out in the study. Also, the results obtained indicated that CRU climatic data series were normally distributed and parametric methods could be used in further analysis of the data. Rainfall data homogeneity was detected for Bayelsa, Delta, Edo, Lagos, Ogun, and Ondo states and inhomogeneity for Akwa Ibom, Cross Rivers, and Rivers States. Also, temperature data inhomogeneity was detected for all the states in the study area.
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Ghebreyesus, Dawit, and Hatim O. Sharif. "Time Series Analysis of Monthly and Annual Precipitation in The State of Texas Using High-Resolution Radar Products." Water 13, no. 7 (2021): 982. http://dx.doi.org/10.3390/w13070982.
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Precipitation is the main source for replenishing groundwater stored in aquifers for a myriad of beneficial purposes, especially in arid and semi-arid regions. A significant portion of the municipal and agricultural water demand is satisfied through groundwater withdrawals in Texas. These withdrawals have to be monitored and regulated to be in balance with the recharge amount from precipitation in order to ensure water security. The main goal of this study is to understand the spatio-temporal variability of precipitation in the 21st century using high spatial resolution stage-IV radar data over the state of Texas and examine some climatic controls behind this variability. The results will shed light on the trends of precipitation and hence will contribute to improving water resources management strategies and policies. Pettit’s test and Standard Normal Homogeneity Test (SNHT), tools for detecting change-point in the monthly precipitation, suggested change-points have occurred across the state around the years 2013 and 2014. The test for the homogeneity of the data before and after 2013 revealed that, in over 64% of the state, the precipitation means were significantly different. The Panhandle region (northern part) is the only part of the state that did not show a significant difference in the mean precipitation before and after 2013. Theil-Sen’s slope test, Correlated Seasonal Mann-Kendall Test, and Cox and Stuart Trend Test all indicated that there were no significant trends in the monthly precipitation after 2013 in over 98% of the area of the state. Texas precipitation was found to be influenced significantly by the El Niño-Southern Oscillation (ENSO) and the Pacific Decadal Oscillation (PDO). A significant correlation in more than 82% and 60% of the state was found with ENSO at two-month and with PDO at four-month lag, respectively.
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Nordli, Øyvind. "The Svalbard Airport Temperature Series." Bulletin of Geography. Physical Geography Series 3, no. 1 (2010): 5–25. http://dx.doi.org/10.2478/bgeo-2010-0001.
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Abstract In the Isfjorden region of Spitsbergen in the Svalbard archipelago, the air temperature has been observed continuously at different sites since 1911 (except for a break during WW II). The thermal conditions at these various sites turned out to be different so that nesting the many series together in one composite time series would produce an inhomogenous long-term series. By using the SNHT (Standard Normal Homogeneity Test) the differences between the sites were assessed and the series adjusted accordingly. This resulted in an homogenised, composite series mainly from Green Harbour (Finneset in Grønfjorden), Barentsburg (also in Grønfjorden), Longyearbyen and the current observation site at Svalbard Airport. A striking feature in the series is a pronounced, abrupt change from cold temperature in the 1910s to warmth in the 1930s, when temperature reached a local maximum. This event is called the early 20th century warming. Thereafter the temperature decreased to a local minimum in the 1960s before the start of another increase that still seems to be ongoing. For the whole series, statistically significant positive trends were detected by the Mann-Kendall test for annual and seasonal values (except for winter). Quite often the Norwegian Meteorological Institute receives queries about long-term temperature series from Svalbard. Hopefully, the Svalbard Airport composite series will fulfil this demand for data. It may be downloaded free of charge from the Institute’s home page: http://sharki.oslo.dnmi.no and should be used with reference to this article.
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Gadedjisso-Tossou, Agossou, Komlavi II Adjegan, and Armand Ketcha Malan Kablan. "Rainfall and Temperature Trend Analysis by Mann–Kendall Test and Significance for Rainfed Cereal Yields in Northern Togo." Sci 2, no. 4 (2020): 74. http://dx.doi.org/10.3390/sci2040074.
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This study investigates the trend in monthly and annual rainfall, minimum and maximum temperature (Tmin and Tmax) using the Mann–Kendall (MK) test and Sen’s slope (SS) method and evaluates the significance of their variability for maize, sorghum and millet yields in northern Togo employing multiple regression analysis. The historical data of Kara, Niamtougou, Mango and Dapaong weather stations from 1977 to 2012 were used. Four non-parametric methods—Alexandersson’s Standard Normal Homogeneity Test (SNHT), Buishand’s Range Test (BRT), Pettitt’s Test (PT) and Von Neumann’s Ratio Test (VNRT)—were applied to detect homogeneity in the data. For the data which were serially correlated, a modified version of the MK test (pre-whitening) was utilised. Results showed an increasing trend in the annual rainfall in all four locations. However, this trend was only significant at Dapaong (p < 0.1). There was an increasing trend in Tmax at Kara, Mango and Niamtougou, unlike Dapaong where Tmax revealed a significant decreasing trend (p < 0.01). Similarly, there was an increasing trend in Tmin at Kara, Mango and Dapaong, unlike Niamtougou where Tmin showed a non-significant decreasing trend (p > 0.05). Rainfall in Dapaong was found to have increased (7.79 mm/year) more than the other locations such as Kara (2.20 mm/year), Niamtougou (4.57 mm/year) and Mango (0.67 mm). Tmax increased by 0.13, 0.13 and 0.32 °C per decade at Kara, Niamtougou and Mango, respectively, and decreased by 0.20 per decade in Dapaong. Likewise, Tmin increased by 0.07, 0.20 and 0.02 °C per decade at Kara, Mango and Dapaong, respectively, and decreased by 0.01 °C per decade at Niamtougou. Results of multiple regression analysis revealed nonlinear yield responses to changes in rainfall and temperature. Rainfall and temperature variability affects rainfed cereal crops production, but the effects vary across crops. The temperature has a positive effect on maize yield in Kara, Niamtougou and Mango but a negative effect on sorghum in Niamtougou and millet in Dapaong, while rainfall has a negative effect on maize yield in Niamtougou and Dapaong and millet yield in Mango. In all locations, rainfall and temperature variability has a significant effect on the cereal crop yields. There is, therefore, a need to adopt some adaptation strategies for sustainable agricultural production in northern Togo.
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Gadedjisso-Tossou, Agossou, Komlavi II Adjegan, and Armand Ketcha Malan Kablan. "Rainfall and Temperature Trend Analysis by Mann–Kendall Test and Significance for Rainfed Cereal Yields in Northern Togo." Sci 3, no. 1 (2021): 17. http://dx.doi.org/10.3390/sci3010017.
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This study investigates the trend in monthly and annual rainfall, minimum and maximum temperature (Tmin and Tmax) using the Mann–Kendall (MK) test and Sen’s slope (SS) method and evaluates the significance of their variability for maize, sorghum and millet yields in northern Togo employing multiple regression analysis. The historical data of Kara, Niamtougou, Mango and Dapaong weather stations from 1977 to 2012 were used. Four non-parametric methods—Alexandersson’s Standard Normal Homogeneity Test (SNHT), Buishand’s Range Test (BRT), Pettitt’s Test (PT) and Von Neumann’s Ratio Test (VNRT)—were applied to detect homogeneity in the data. For the data which were serially correlated, a modified version of the MK test (pre-whitening) was utilised. Results showed an increasing trend in the annual rainfall in all four locations. However, this trend was only significant at Dapaong (p < 0.1). There was an increasing trend in Tmax at Kara, Mango and Niamtougou, unlike Dapaong where Tmax revealed a significant decreasing trend (p < 0.01). Similarly, there was an increasing trend in Tmin at Kara, Mango and Dapaong, unlike Niamtougou where Tmin showed a non-significant decreasing trend (p > 0.05). Rainfall in Dapaong was found to have increased (7.79 mm/year) more than the other locations such as Kara (2.20 mm/year), Niamtougou (4.57 mm/year) and Mango (0.67 mm). Tmax increased by 0.13, 0.13 and 0.32 °C per decade at Kara, Niamtougou and Mango, respectively, and decreased by 0.20 per decade in Dapaong. Likewise, Tmin increased by 0.07, 0.20 and 0.02 °C per decade at Kara, Mango and Dapaong, respectively, and decreased by 0.01 °C per decade at Niamtougou. Results of multiple regression analysis revealed nonlinear yield responses to changes in rainfall and temperature. Rainfall and temperature variability affects rainfed cereal crops production, but the effects vary across crops. The temperature has a positive effect on maize yield in Kara, Niamtougou and Mango but a negative effect on sorghum in Niamtougou and millet in Dapaong, while rainfall has a negative effect on maize yield in Niamtougou and Dapaong and millet yield in Mango. In all locations, rainfall and temperature variability has a significant effect on the cereal crop yields. There is, therefore, a need to adopt some adaptation strategies for sustainable agricultural production in northern Togo.
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Mohammed, Ruqayah, and Miklas Scholz. "Climate Variability Impact on the Spatiotemporal Characteristics of Drought and Aridityin Arid and Semi-Arid Regions." Water Resources Management 33, no. 15 (2019): 5015–33. http://dx.doi.org/10.1007/s11269-019-02397-3.
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AbstractInvestigating the spatiotemporal distribution of climate data and their impact on the allocation of the regional aridity and meteorological drought, particularly in semi-arid and arid climate, it is critical to evaluate the climate variability effect and propose sufficient adaptation strategies. The coefficient of variation, precipitation concentration index and anomaly index were used to evaluate the climate variability, while the Mann-Kendall and Sen’s slope were applied for trend analysis, together with homogeneity tests. The aridity was evaluated using the alpha form of the reconnaissance drought index (Mohammed & Scholz, Water Resour Manag 31(1):531–538, 2017c), whereas drought episodes were predicted by applying three of the commonly used meteorological drought indices, which are the standardised reconnaissance drought index, standardized precipitation index and standardized precipitation evapotranspiration index. The Upper Zab River Basin (UZRB), which is located in the northern part of Iraq and covers a high range of climate variability, has been considered as an illustrative basin for arid and semi-arid climatic conditions. There were general increasing trends in average temperature and potential evapotranspiration and decreasing trends in precipitation from the upstream to the downstream of the UZRB. The long-term analysis of climate data indicates that the number of dry years has temporally risen and the basin has experienced succeeding years of drought, particularly after 1994/1995. There was a potential link between drought, aridity and climate variability. Pettitt’s, SNHT, Buishand’s and von Neumann’s homogeneity test results demonstrated that there is an evident alteration in the mean of the drought and aridity between the pre- and post-alteration point (1994).
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Langhammer, Jakub, and Jana Bernsteinová. "Which Aspects of Hydrological Regime in Mid-Latitude Montane Basins Are Affected by Climate Change?" Water 12, no. 8 (2020): 2279. http://dx.doi.org/10.3390/w12082279.
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This study analyzed the long-term alterations in runoff regime, seasonality and variability in headwater montane basins in Central Europe in response to the manifestations of climate change. We tested the common hypotheses on climate change effects on surface runoff dynamics in the Central Europe region, assuming that (i) recent climate warming will result in shifts in the seasonality of runoff, (ii) the runoff balance will remain without significant changes and (iii) that higher variability in runoff can be expected. The analyses were done on eight montane catchments in four mid-latitude mountain ranges in Central Europe, based on the uninterrupted time series of daily discharge observations from 1952 to 2018. We used 33 indicators of hydrologic alteration (IHA), 34 indicators of environmental flow components, the baseflow index, the calculation of surplus and deficit volumes and the frequency of peak and low flows. Homogeneity testing using Buishand, Pettitt and SNHT tests was applied to test the response of the hydrological alteration indicators to climate warming. We have proved the significant shifts in runoff seasonality, coinciding with the timing of the air temperature rise, marked by earlier snowmelt, followed by a decline in spring flows and a prolonged period of low flows. There was detected a rise in the baseflow index across the mountain ranges. Unlike the common hypotheses, the expected rise of runoff variability and frequency of peak flows was not demonstrated. However, we have identified a significant change of the flood hydrographs, tending to steeper shape with shorter recessing limbs as a sign of rising inner dynamics of flood events in montane catchments.
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Sharma, Vivek, Christopher Nicholson, Antony Bergantino, Suat Irmak, and Dannele Peck. "Temporal Trend Analysis of Meteorological Variables and Reference Evapotranspiration in the Inter-mountain Region of Wyoming." Water 12, no. 8 (2020): 2159. http://dx.doi.org/10.3390/w12082159.
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Long-term trends in reference evapotranspiration (ETref) and its controlling factors are critical pieces of information in understanding how agricultural water requirements and water resources respond to a variable and changing climate. In this study, ETref, along with climate variables that directly and indirectly impact it, such as air temperature (T), incoming solar radiation (Rs), wind speed (u), relative humidity (RH), and precipitation (P), are discussed. All variables are analyzed for four weather stations located in irrigated agricultural regions of inter-mountain Wyoming: Pinedale, Torrington, Powell, and Worland. Non-parametric Mann−Kendall (MK) trend test and Theil–Sen’s slope estimator were used to determine the statistical significance of positive or negative trends in climate variables and ETref. Three non-parametric methods—(i) Pettitt Test (PT), (ii) Alexandersson’s Standard Normal Homogeneity Test (SNHT), and (iii) Buishand’s Range Test (BRT)—were used to check the data homogeneity and to detect any significant Trend Change Point (TCP) in the measured data time-series. For the data influenced by serial correlation, a modified version of the MK test (pre-whitening) were applied. Over the study duration, a statistically significant positive trend in maximum, minimum, and average annual temperature (Tmax, Tmin, and Tavg, respectively) was observed at all stations, except for Torrington in the southeast part of Wyoming, where these temperature measures had negative trends. The study indicated that the recent warming trends are much more pronounced than during the 1930s Dust Bowl Era. For all the stations, no TCPs were observed for P; however, significant changes in trends were observed for Tmax and Tmin on both annual and seasonal timescales. Both grass and alfalfa reference evapotranspiration (ETo and ETr) had statistically significant positive trends in at least one season (in particular, the spring months of March, April, and May (MAM) or summer months of June, July, and August (JJA) at all stations, except the station located in southeast Wyoming (Torrington) where no statistically significant positive trends were observed. Torrington instead experienced statistically significant negative trends in ETo and ETr, particularly in the fall months of SON and winter months of DJF. Over the period-of-record, an overall change of +26, +31, −48, and +34 mm in ETo and +28, +40, −80, and +39 mm in ETr was observed at Pinedale, Powell, Torrington, and Worland, respectively. Our analysis indicated that both ETo (−3.4 mm year−1) and ETr (−5.3 mm year−1) are decreasing at a much faster rate in recent years at Torrington compared to other stations. Relationships between climate variables and ETo and ETr on an annual time-step reveal that ETo and ETr were significantly and positively correlated to Tavg, Tmax, Rs, Rn, and VPD, as well as significantly and negatively correlated to RH.
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Takhar, A., J. Stephens, P. S. Randhawa, A. L. Poirrier, and P. Andrews. "Validation of the sino-nasal outcome test-23 in septorhinoplasty surgery." Rhinology journal 52, no. 4 (2014): 301–4. http://dx.doi.org/10.4193/rhino14.009.
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Background: There has been a great expansion in patient-based outcome measures to face the ever-increasing demand to demonstrate surgical efficacy. However, surgeons have not adopted until now any systematic outcome instrument. The 22-item Sino-Nasal Outcome Test (SNOT-22) is a validated sinonasal outcome score in sinonasal and septorhinoplasty surgery but does not measure aesthetic outcome. The aim of this paper is to validate a modification to the Sino-Nasal Outcomes Test-22 (SNOT-22) with a new question regarding the shape of the nose (SNOT-23). Methodology: We conducted a prospective cohort study on 69 consecutive patients undergoing septorhinoplasty and a control group of healthy volunteers. Reproducibility, responsiveness to treatment, known group differences and validity of the SNOT-23 were analysed. Scores were compared to visual analogue scales, nasal obstruction symptoms evaluation (NOSE) score and nasal inspiratory peak flow. Results: SNOT-23 has good test-retest reliability and is a valid outcome measure for assessing response to surgery especially with regards to shape of the nose and nasal obstruction when compared to other patient reported measures. Conclusion: SNOT-23 is a valid and reliable tool that can be easily used in routine clinical practice to assess the functional and aesthetic outcomes from septorhinoplasty surgery. The SNOT-23 could be adopted as a universal, easy to use tool in rhinology clinics for the assessment of response to septorhinoplasty and sinus surgery.
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Tait, Sarah D., Dorina Kallogjeri, Smrithi Chidambaram, John Schneider, and Jay F. Piccirillo. "Psychometric and Clinimetric Validity of the Modified 25-Item Sino-Nasal Outcome Test." American Journal of Rhinology & Allergy 33, no. 5 (2019): 577–85. http://dx.doi.org/10.1177/1945892419851622.
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Background Productivity losses are a significant part of the disease burden associated with rhinosinusitis, but existing measures of disease-specific quality of life exclude explicit assessment of the impact of the disease on productivity. Objective The objective of this study was to evaluate the clinimetric and psychometric validity of the 25-item Sino-Nasal Outcome Test (SNOT-25), a modified version of the SNOT-22. Methods This was a prospective cohort study conducted at an academic medical center. Participants included adult patients with rhinosinusitis who presented for routine visits to the Washington University in St. Louis School of Medicine otolaryngology clinic between August 2016 and March 2017. Results The SNOT-25 was created with the addition of three productivity-specific items to the SNOT-22 instrument. A total of 120 rhinosinusitis patients completed all baseline measurements and 94 (78.3%) completed 3-month follow-up. The Cronbach’s α was 0.83, indicating high internal consistency. Rhinosinusitis patients had on average a 24-point higher baseline SNOT-25 score (95% confidence interval [CI]: 13–35) as compared to healthy controls indicating good discriminative validity. There was high correlation between SNOT-25 scores at 3 months and 3.5 months ( r = .81; 95% CI, 0.73–0.87) confirming strong test–retest reliability. SNOT-25 had a strong correlation with the overall score of the Nasal Obstruction Symptom Evaluation instrument ( r = .55; 95% CI, 0.42–0.65), and among Short Form-36 subscales, the strongest correlations existed between SNOT-25 and the fatigue scale ( r = −.522; 95% CI, −0.63 to −0.39). Exploratory factor analysis revealed that the 3 new questions of SNOT-25 loaded together with reduction in productivity and concentration items on a new “productivity” factor. Conclusion The SNOT-25 is a valid instrument that can be used to assess rhinosinusitis disease burden including the impact on productivity and may be a better predictor of treatment decisions and outcomes.
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Maningding, Christine Anne C., and Rodante A. Roldan. "Reliability and Validity of the Filipino Sino-Nasal Outcome Test (SNOT) 22." Philippine Journal of Otolaryngology-Head and Neck Surgery 33, no. 1 (2018): 17–20. http://dx.doi.org/10.32412/pjohns.v33i1.51.
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Objective: To translate the Sino-Nasal Outcome Test (SNOT) 22 into Filipino, and establish the validity and reliability of the Filipino version of the Sino-Nasal Outcome Test (SNOT) 22.
 
 Methods:
 Design: Prospective Cohort
 Setting: Tertiary Government Training Hospital
 Participants: Twenty one (21) patients with rhinosinusitis with or without nasal polyposis were administered the Filipino SNOT 22 to determine reliability. Sixty three (63) patients with rhinosinusitis with or without nasal polyps and forty eight (48) controls were recruited for the validity study.
 
 Results: The Filipino SNOT 22 had a Pearson correlation of 0.618 significant at the 0.01 level and a Cronbach’s alpha of 0.76. The calculated Z-Score was 7.21 with p-value < .00001 significant at p < .05. The value of U was 300 with a critical U value at 1512.
 
 Conclusion: The self administered Filipino SNOT 22 is a reliable and valid tool for measuring QOL among Filipino patients with rhinosinusitis.
 
 Keywords: sinusitis, reliability and validity, quality of life, sino-nasal outcome test 22
 
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Li, WenXiao, and Yongxin Yang. "Method to test the durability of fiber-reinforced polymers based on elastic modulus." Advances in Structural Engineering 23, no. 15 (2020): 3195–207. http://dx.doi.org/10.1177/1369433220923810.
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The performance degradation of fiber-reinforced polymer is often assessed based on the ultimate strength obtained during a destructive test. This method has the advantages of simple operation, clear internal mechanism, and noticeable data variation. However, because fiber-reinforced polymers are composed of high molecular compounds, their properties are influenced by several factors, such as the manufacturing process and composition ratio. Without a unified benchmark, it is difficult to unify destructive test data obtained by different researchers and organizations. In this study, a new test method named SNFT (Same Non-failure FRP Test) is proposed for assessing the durability of fiber-reinforced polymers. SNFT is a testing method in which the same specimen can be repeatedly tested at different aging periods. The rationality of the SNFT method is analyzed using the displacement compatibility between the degraded zone and the undegraded zone. The conversion principle based on the degraded degree between the destructive test and the SNFT method is deduced by calculation. An experimental test was designed to investigate the test conditions and control parameters of the SNFT method. SNFT and synchronous destructive tests on glass fiber–reinforced plastic were carried out under the conditions of wet heat and alkali solution, and the theoretical results were compared and verified with data in the literature. The results show that compared with the traditional durability destructive test method, the SNFT method shows more consistent data and less data fluctuation and incurs a lower test cost. The elastic modulus, adopted as the durability benchmark, can be similar to the test results of traditional destructive test methods and could be transformed based on the transformation relationship proposed in this article. The degradation of fiber-reinforced polymer in different environments is characterized by the variation in elastic modulus measured using the SNFT method. This study provides a theoretical basis for establishing a unified benchmark of durability tests and data and supports the quantitative design of durability.
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Yeolekar, Aditya M., Vidya Rokade, Kiran Shinde, Netra Pathak, Haris Qadri, and Kaustubh Kahane. "Sino-Nasal Outcome Test-22: Translation, Cross-cultural Adaptation, and Validation in Local Language." Bengal Journal of Otolaryngology and Head Neck Surgery 26, no. 1 (2018): 10–15. http://dx.doi.org/10.47210/bjohns.2018.v26i1.150.
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Introduction
 Quality of life questionnaires have been increasingly used in clinical studies to help estimate the magnitude of problem. Sino-Nasal Outcome Test -22 (SNOT-22) is considered to be a good tool to measure the severity of Sino-Nasal Diseases. As this test is in English, it may be difficult for the local population to express their symptoms correctly. Therefore we have translated and validated the SNOT- 22 test in local Indian language, Marathi.
 Materials and Methods
 An early Indian ( Marathi ) version of the SNOT 22 questionnaire was prepared. This was a prospective study,where forty patients with Sino-nasal Diseases confirmed on DNE & CT(PNS) filled the questionnaire. This was repeated after a period of 14 days to retest. For validation the questionnaire was also filled by healthy individuals.
 Results
 The mean SNOT-22 score ± SD was 50.17 ± 18.65 (range 10–93) in the initial test, and 49.61 ± 18.40 (range 21–91) in retest in the study group. Cronbach’s alpha was 0.835 and 0.837 at the initial and retest examination respectively, both values were suggesting a good internal consistency. The mean SNOT-22 score ± SD was 13 ± 11.68 in the control group and 49.61 ± 18.40 (range 21–91) in the sino-nasal disease group and proved by Mann- Whitney U test.
 Conclusion 
 The Marathi SNOT-22 is a valid instrument to assess the symptomatology of patients of Sino-nasal Diseases in Maharashtra.
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Oliver, Jeremie D., Kaiser G. Lim, and Erin K. O’Brien. "Correlation of Exhaled Nasal Nitric Oxide With Sinus Computed Tomography and Sinonasal Outcome Test Scores: A Cross-sectional Pilot Study." American Journal of Rhinology & Allergy 32, no. 6 (2018): 533–38. http://dx.doi.org/10.1177/1945892418801389.
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Background Computed tomography (CT) of the paranasal sinuses is the diagnostic reference standard for chronic rhinosinusitis and related inflammatory sinus pathology. Nasal nitric oxide (nNO) levels have been investigated as a diagnostic tool in sinus disease because it decreases with sinus obstruction. Objective The primary aim of the study was to determine the correlation of passive (baseline) and dynamic (humming) nNO to CT findings of sinus inflammation and to sinonasal symptoms measured by the modified Sinonasal Outcome Test (26 items) (SNOT-26). Methods From June 2015 through January 2016, subjects had baseline and humming nNO levels measured with a chemiluminescence NO analyzer, and each subject underwent CT imaging and completed the SNOT-26 survey. CT images were scored using the Lund–Mackay (LM) system (LM scores >3 indicated sinus inflammation). Correlation was measured by linear and ordinal regression analysis that compared SNOT-26 scores, LM scores, and nNO measurements. Results Fourteen subjects were recruited. LM scores had a positive pairwise correlation with total SNOT-26 scores ( R2 = .1457; correlation = .3817) and nasal-specific SNOT-26 scores ( R2 = .4036; correlation = .6353). Baseline nasal nNO scores had a negative pairwise correlation with LM scores ( R2 = .1580; correlation = −.3582), total SNOT-26 scores ( R2 = .1515; correlation = −.3893), and nasal-specific SNOT-26 scores ( R2 = .0805; correlation = −.4343). Although baseline nNO levels correlated with LM and SNOT-26 scores, humming nNO levels did not show a similar correlation. Conclusion Baseline passive nNO may be a useful and inexpensive point-of-care screening test for sinonasal opacification.
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Leong, S. C., H. K. Tsang, M. D. Wilkie, and G. Banhegyi. "Characterisation of patients with endoscopy-negative, computer tomography-negative midfacial segment pain using the sino-nasal outcome test." Rhinology journal 52, no. 1 (2014): 78–83. http://dx.doi.org/10.4193/rhino13.123.
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Background: The purpose of this study was to qualitatively characterise patients with midfacial segment pain (MSP) using the Sino-Nasal Outcome Test (SNOT). The data will provide a detailed overview of the physical and psychological impact on patients'well-being, and how it compares with the normal, healthy population. Methods: Suitable patients were prospectively identified from the Multi-disciplinary Facial Pain Clinic at the Royal Liverpool University Hospital, based on the diagnostic criteria for MSP. The pre-treatment SNOT-22 of these patients were also compared to patients with chronic rhinosinusitis and normal healthy volunteers. Results: Twenty-nine consecutive patients with a diagnosis of MSP were identified, and compared with 30 CRS patients and 34 healthy volunteers. The average SNOT-22 scores of MSP and CRS patients were higher than normal healthy volunteers. Patients with CRS had the highest rhinological subscale SNOT scores compared to normal healthy volunteers and MSP. Conversely, the reported ear and facial symptoms of MSP patients were most unfavourable. A similar trend was observed in reported sleep function where MSP patients recorded higher subscale scores than the other two cohorts. The subscale mean score for psychological function of MSP patients was not significant when compared to the mean score of patients diagnosed with CRS. Conclusion: MSP has an adverse impact on both physical and psychological well-being. The subtle differences in the SNOT subscores between MSP and CRS have provided greater insight into the character and disease impact of MSP. We propose that the SNOT may be suitably utilised in MSP to document disease severity and measure response to treatment.
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Husain, Qasim, Lloyd Hoehle, Katie Phillips, David S. Caradonna, Stacey T. Gray, and Ahmad R. Sedaghat. "The 22-Item Sinonasal Outcome Test as a Tool for the Assessment of Quality of Life and Symptom Control in Allergic Rhinitis." American Journal of Rhinology & Allergy 34, no. 2 (2019): 209–16. http://dx.doi.org/10.1177/1945892419884789.
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Background The 22-item Sinonasal Outcome Test (SNOT-22) is a validated patient-reported outcome measure for chronic rhinosinusitis and in many circumstances is used in rhinology/otolaryngology clinics to assess sinonasal symptoms in general when a formal diagnosis is not established, although with little support for such usage. Objective To assess the utility of the SNOT-22 as a reflection of quality of life (QOL) and symptom control for patients with allergic rhinitis (AR). Methods Retrospective review of 353 patients with persistent AR. Each patient completed a SNOT-22, 5-item EuroQol general health-related QOL (EQ-5D) questionnaire (from which the visual analog scale [VAS] was used), and Rhinitis Control Assessment Test (RCAT). In addition, 95 patients also completed these questionnaires 1 to 12 months later. Results The SNOT-22 was negatively correlated with the EuroQol 5-dimensional visual analog scale (EQ-5D VAS; r = −.45, 95% confidence interval [CI]: −0.53 to −0.36, P < .001) and RCAT ( r = −.62, 95% CI: −0.68 to −0.55, P < .001), with excellent internal consistency. The SNOT-22 demonstrated responsiveness, with mean change of −5.8 (95% CI: −8.9 to −2.6, P < .001) from pre- to posttreatment. The change in SNOT-22 over the treatment period was correlated with change in EQ-5D VAS ( r = −.28, 95% CI: −0.46 to −0.07, P = .008) and RCAT ( r = −.56, 95% CI: −0.69 to −0.41, P < .001). The minimal clinically important difference was calculated to be between 6 and 11. Conclusion The SNOT-22 has utility to assess QOL and symptom control in AR, and it is both reliable and responsive in its application to patients with AR. The SNOT-22 may therefore be a convenient and versatile tool in the clinical assessment of patients with AR.
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Lauriello, Maria, Vittoria Di Rubbo, Gaia Sinatti, et al. "Correlation Between SNOT-22, Nasal Cytology, and Mood Disorders in Patients With Allergic Rhinitis Treated With a Liposomal Nasal Spray." Allergy & Rhinology 10 (January 2019): 215265671986680. http://dx.doi.org/10.1177/2152656719866809.
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Patients with allergic rhinitis (AR) can suffer from mood disorders. The aim of this study was to investigate the clinical effect of a liposomal nasal spray (LN) containing vitamins A and E on the nasal mucosa in patients suffering from AR who had refused any type of anti-allergic treatment. For this purpose, the results of nasal cytology, Visual Analog Scale (VAS), Sino-Nasal Outcome Test-22 (SNOT-22), and Hospital Anxiety and Depression Scale (HADS) test were analyzed. Moreover, we evaluated the relationship between SNOT-22 and nasal cytology and between nasal symptoms and HADS scores. Statistical analysis revealed a significant decrease of scores at T1 in the LN treatment group as concerns VAS, SNOT-22, HADS-Anxiety test and a remarkable reduction of inflammatory cells detected with nasal cytology. Our study showed that higher levels of SNOT-22 corresponded to a higher level of HADS-Anxiety. The mechanisms underlying this relationship in AR patients are currently unknown, but we can suppose that improving mucosal trophism may contribute to the decrease of nasal symptoms and anxiety scores. The improvement of nasal symptoms, as measured by SNOT-22, was significantly correlated with the objective results of nasal cytology. These relationships between SNOT-22 and nasal cytology and between anxiety and cytology were investigated for the first time in our research.
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Tetsuo, Madoka, Keita Matsuno, Tomokazu Tamura, et al. "Development of a High-Throughput Serum Neutralization Test Using Recombinant Pestiviruses Possessing a Small Reporter Tag." Pathogens 9, no. 3 (2020): 188. http://dx.doi.org/10.3390/pathogens9030188.
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A serum neutralization test (SNT) is an essential method for the serological diagnosis of pestivirus infections, including classical swine fever, because of the cross reactivity of antibodies against pestiviruses and the non-quantitative properties of antibodies in an enzyme-linked immunosorbent assay. In conventional SNTs, an immunoperoxidase assay or observation of cytopathic effect after incubation for 3 to 7 days is needed to determine the SNT titer, which requires labor-intensive or time-consuming procedures. Therefore, a new SNT, based on the luciferase system and using classical swine fever virus, bovine viral diarrhea virus, and border disease virus possessing the 11-amino-acid subunit derived from NanoLuc luciferase was developed and evaluated; this approach enabled the rapid and easy determination of the SNT titer using a luminometer. In the new method, SNT titers can be determined tentatively at 2 days post-infection (dpi) and are comparable to those obtained by conventional SNTs at 3 or 4 dpi. In conclusion, the luciferase-based SNT can replace conventional SNTs as a high-throughput antibody test for pestivirus infections.
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Essawy, Wessam Mostafa. "Application of Arabic hearing in noise test on subjects with sensorineural hearing loss." International Journal of Otorhinolaryngology and Head and Neck Surgery 5, no. 6 (2019): 1635. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20194940.
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<p class="abstract"><strong>Background:</strong> HINT sentence test is one of adaptive speech in noise tests. It has been used in many clinical applications such as recording of speech perception threshold using sentences material in quiet and in noise and verifying the benefit from hearing-aid amplification and cochlear implants, especially in noise. This study was designed to apply HINT to subjects with SNHL to get a normative data for this group.</p><p class="abstract"><strong>Methods:</strong> This study included 50 subjects with bilateral mild to moderate sensorineural hearing loss. </p><p class="abstract"><strong>Results:</strong> In SNHL subjects, the mean of sSRT in quiet was 49.46 dB (A)±0.68 dB. The mean of S/N ratio at threshold was 7.69 S/N ratio ±0.68, -8.18±0.33 and -8.18±0.35 in the noise conditions 0°, 90° and 270° respectively.</p><p><strong>Conclusions:</strong> The statistical reliability and efficiency of the test suit it to practical applications especially in SNHL subjects. </p>
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Ling, Francis T. K., and Stilianos E. Kountakis. "Rhinosinusitis Task Force Symptoms versus the Sinonasal Outcomes Test in Patients Evaluated for Chronic Rhinosinusitis." American Journal of Rhinology 21, no. 4 (2007): 495–98. http://dx.doi.org/10.2500/ajr.2007.21.3052.
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Background The aim of this study was to compare Rhinosinusitis Task Force (RSTF) symptom scores with Sinonasal Outcome Test 20 (SNOT-20) in patients with chronic rhinosinusitis (CRS) and controls. Methods An analysis was performed of prospectively collected data in patients with CRS (n = 201) and controls (n = 100). The severity of individual RSTF major and minor symptom scores graded on a visual analog scale and total symptom scores were compared between the two groups. Correlation of the RSTF symptoms with the SNOT-20 was performed using data collected from the CRS group at baseline and at 1 year postoperatively. Results CRS patients had higher RSTF symptom scores compared with control patients when asked to rate the severity of nasal obstruction, facial pain/pressure, facial congestion, alteration of smell, nasal discharge, postnasal drip, headache, halitosis, fatigue, cough, and ear pain (p < 0.005). No statistically significant difference was seen for the symptoms of dental pain and fever. Total RSTF scores were 54.5 ± 1.9 in CRS patients versus 23.4 ± 3.0 in controls. Total SNOT-20 scores were 28.7 ± 0.8 in CRS patients versus 15.2 ± 0.6 in controls. In CRS patients, total RSTF scores correlated with total SNOT-20 scores at baseline (r = 0.36; p < 0.0001) and 1-year postoperatively (r = 0.37; p < 0.0001). Conclusion Total RSTF symptom scores are significantly different in patients with chronic rhinosinusitis compared with those without this disease. The total RSTF symptom scores also correlate with a validated outcome measures instrument.
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Safdar, Rabia Saleem, M. Faisal Mehar, Madiha Naz, Afsheen Asghar Khan, Nusrat Buzdar, and Tooba Aleem. "Frequency of sensorineural hearing loss in children with bacterial meningitis." Professional Medical Journal 27, no. 12 (2020): 2729–33. http://dx.doi.org/10.29309/tpmj/2020.27.12.4672.
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Objectives: To determine the frequency of sensorineural hearing loss (SNHL) in children with bacterial meningitis. Study Design: Cross Sectional study. Setting: Department of Paediatric Medicine Nishtar Hospital, Multan. Period: October 2019 to March 2020. Material & Methods: The study was conducted after permission from ethical committee. A total of 151 patients admitted with bacterial meningitis were enrolled. Apart from the presenting complaints, necessary information like the age and gender were noted. Examination of the child was done to assess the condition of child. Brainstem evoked response audiometry (BERA) test was performed before discharge of the patient from the hospital. The outcome variable that is SNHL in bacterial meningitis assessed by BERA test was noted in a specifically designed Performa. Results: Out of total of 151 patients, males were 83 (55%) while females 68 (45%). Overall mean age was 11.85+6.12 months. SNHL was found in 26 (17.2%) children. There was no significant effect of age or gender on the frequencies of SNHL. Conclusion: SNHL is a frequently encountered complication in our population of children with bacterial meningitis. SNHL should be carefully sought out and properly diagnosed in all the patients presenting with bacterial meningitis.
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Hancı, Deniz, Hüseyin Altun, Ethem Şahin, Niyazi Altıntoprak, and Cemal Cingi. "Turkish translation, cross-cultural adaptation and validation of the SinoNasal Outcome Test (SNOT)-22." ENT Updates 5, no. 2 (2015): 51–57. http://dx.doi.org/10.2399/jmu.2015002001.
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Li, Jennifer, Gracie Palmer, Suraj Shankar, et al. "Essential Oil Olfactory Test: Comparison of Affordable Rapid Olfaction Measurement Array (AROMA) to Sniffin’ Sticks 12." OTO Open 4, no. 4 (2020): 2473974X2096246. http://dx.doi.org/10.1177/2473974x20962464.
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Objectives To further demonstrate the validity of Affordable Rapid Olfaction Measurement Array (AROMA), an essential oil−based smell test, and compare it to the Sniffin’ Sticks 12 Test (SST12). Study Design Prospective cross-sectional study. Setting Academic medical center. Methods Fifty healthy individuals without sinonasal disease were recruited to the study. AROMA has been previously validated against the University of Pennsylvania Smell Identification Test. The current study tests 2 additional higher concentrations to increase the ability to detect olfactory reserve. Healthy participants completed AROMA, SST12, Sino-Nasal Outcome Test (SNOT-22), and Questionnaire of Olfactory Disorders (QoD). Spearman correlations were used to evaluate AROMA, SST, SNOT-22, and QoD. Results AROMA demonstrated strong test-retest reliability ( r = 0.757, P < .01). AROMA showed a moderate correlation to SST12 (ρ = 0.412, P < .01). Age and SNOT-22 were significantly correlated ( P < .05) with AROMA (ρ = −0.547, −0.331, respectively), and age was weakly correlated with SST (ρ = −0.377, P < .01). Median percent correct scores were as follows: SST12 identification, 92%; AROMA detection, 90%; and AROMA identification, 81%. Median correct odor identification of AROMA concentrations at 1×, 2×, 4×, and 8× were 64%, 75%, 92%, and 92%, respectively. Conclusion AROMA has a moderate correlation with SST12. AROMA is more strongly correlated than SST12 to age and SNOT-22. AROMA’s stronger correlation with subjective olfactory status, low cost, and adaptability may help remove barriers to routine olfactory testing in the clinic.
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Sakuma, Naoko, Hideaki Moteki, Hela Azaiez, et al. "Novel PTPRQ Mutations Identified in Three Congenital Hearing Loss Patients With Various Types of Hearing Loss." Annals of Otology, Rhinology & Laryngology 124, no. 1_suppl (2015): 184S—192S. http://dx.doi.org/10.1177/0003489415575041.
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Objectives: We present 3 patients with congenital sensorineural hearing loss (SNHL) caused by novel PTPRQ mutations, including clinical manifestations and phenotypic features. Methods: Two hundred twenty (220) Japanese subjects with SNHL from unrelated and nonconsanguineous families were enrolled in the study. Targeted genomic enrichment with massively parallel DNA sequencing of all known nonsyndromic hearing loss genes was performed to identify the genetic cause of hearing loss. Results: Four novel causative PTPRQ mutations were identified in 3 cases. Case 1 had progressive profound SNHL with a homozygous nonsense mutation. Case 2 had nonprogressive profound SNHL with a compound heterozygous mutation (nonsense and missense mutation). Case 3 had nonprogressive moderate SNHL with a compound heterozygous mutation (missense and splice site mutation). Caloric test and vestibular evoked myogenic potential (VEMP) test showed vestibular dysfunction in Case 1. Conclusion: Hearing loss levels and progression among the present cases were varied, and there seem to be no obvious correlations between genotypes and the phenotypic features of their hearing loss. The PTPRQ mutations appeared to be responsible for vestibular dysfunction.
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Rodgers, Sandra J., Shelia L. Karges, and Jeremiah T. Saliki. "Evaluation of a Semiautomated Latex Agglutination Test for the Detection of Pseudorabies Antibody in Swine Sera." Journal of Veterinary Diagnostic Investigation 8, no. 2 (1996): 168–71. http://dx.doi.org/10.1177/104063879600800205.
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Rapid screening of large numbers of swine sera for antibody is an essential element in the current eradication program for pseudorabies in the United States. We evaluated a recently introduced commercial semiautomated latex agglutination test (LAT) kit for pseudorabies antibody. A total of 1,191 swine sera were tested using the new procedure and 3 established tests: the manual LAT, the serum neutralization test (SNT), and an enzyme-linked immunosorbent assay (ELISA). There was close agreement among results of semiautomated LAT, the manual LAT, and ELISA but less agreement between semiautomated LAT and SNT. Overall, the sensitivities of the 4 tests were as follows: semiautomated LAT = manual LAT > ELISA > SNT. For 74 samples of known pseudorabies antibody status, the overall specificities were as follows: semi-automated LAT = manual LAT = SNT > ELISA. Because of its relative insensitivity, the SNT should no longer be considered the official “gold” standard for pseudorabies testing in the on-going eradication program. However, because no single test was perfect for all samples, a scheme including 3 tests in the following sequence is recommended: 1) screening using semiautomated LAT or ELISA and 2) confirmation testing of positives by manual LAT and SNT, with any sample that tests positive by any 2 tests being regarded as true positive.
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Boboshko, M. Yu, and E. V. Zhilinskaya. "Speech intelligibility in patients of different ages with chronic sensorineural hearing loss." Russian Otorhinolaryngology 20, no. 4 (2021): 8–14. http://dx.doi.org/10.18692/1810-4800-2021-4-8-14.
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Deterioration in speech intelligibility, the most common complaint of people with hearing loss, leads to social isolation and dramatically reduces the quality of life. The correction of peripheral hearing loss by hearing aid fitting does not always solve this problem in patients with chronic sensorineural hearing loss (SNHL). That is why in the process of audiological examination of patients with complaints of hearing loss, it is necessary to include methods of speech audiometry, which make it possible to comprehensively assess the functioning of the auditory system. The aim of the study: assessment of speech intelligibility in patients of different ages with SNHL. 94 people from 20 to 74 years of age were examined: 54 patients with SNHL (14 young and 40 elderly) and 40 people with normal hearing thresholds (20 young and 20 elderly). Besides the standard audiological examination, speech audiometry testing was conducted: evaluation of monosyllabic words intelligibility in quiet, binaural rapidly alternating speech test, dichotic digits test, Russian matrix sentence test (RuMatrix). Results: Speech intelligibility in elderly patients with SNHL was shown to be significantly worse than in young patients with a similar degree of hearing loss. The RuMatrix test in noise was proved to be the most sensitive test for comprehensive evaluation of the hearing system functioning.
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Krishnaswami, Balasubramanian, Prabu Velayutham, Naveenkumar Pruthivirajan, Sathiyam Murugesan, and Ramkumar Murugesan. "Evaluation of pre-operative sino-nasal outcome test- 22 scores as a predictor of outcome in patients undergoing functional endoscopic sinus surgery for chronic rhinosinusitis." International Journal of Otorhinolaryngology and Head and Neck Surgery 5, no. 4 (2019): 876. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20192070.
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<p class="abstract"><strong>Background:</strong> Numerous factors are to be considered when offering FESS as a treatment for patients with chronic rhinosinusitis (CRS) who have failed conservative medical treatment. The objective is to evaluate the sino-nasal outcome test (SNOT-22) and other patient demographic characteristics as predictors of postsurgical improvement in patients with CRS.</p><p class="abstract"><strong>Methods:</strong> Consecutive adult subjects presenting to the Otolaryngology clinics in a tertiary hospital, with refractory CRS that required surgery were included. Subjects were excluded if they did not complete both pre and post-operative SNOT-22 Questionnaire. Demographic and baseline measures, including allergic rhinitis, asthma and addiction status, Lund Kennedy endoscopic scores and Lund-Mackay computed tomography (CT) scoring were also obtained for each subject. Regression analyses were performed. </p><p class="abstract"><strong>Results:</strong> Fifty-one subjects met criteria and were included. These subjects showed a 55.4% overall improvement in postsurgical SNOT-22 evaluations. Multivariate regression analysis revealed that SNOT-22 items related to “runny nose,” “waking up at night”, “need to blow nose”, and “sneezing” were independent predictors of postsurgical SNOT-22 improvement (p&lt;0.05, for all).</p><p class="abstract"><strong>Conclusions:</strong> ENT surgeons can utilize the SNOT-22 tool to predict the possibility of symptom improvement post FESS in patients with CRS.</p>
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Wang, Jy-An John. "Oak Ridge National Laboratory (ORNL) spiral notch torsion test (SNTT) system." Practical Failure Analysis 3, no. 4 (2003): 23–27. http://dx.doi.org/10.1007/bf02715926.
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Lachanas, Vasileios A., Malamati Tsea, Stergiani Tsiouvaka, Jiannis K. Hajiioannou, Charalampos E. Skoulakis, and John G. Bizakis. "The sino-nasal outcome test (SNOT)-22: validation for Greek patients." European Archives of Oto-Rhino-Laryngology 271, no. 10 (2014): 2723–28. http://dx.doi.org/10.1007/s00405-014-2969-7.
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Zhou, Allen S., Anthony A. Prince, Alice Z. Maxfield, and Jennifer J. Shin. "Psychological Status as an Effect Modifier of the Association Between Sinonasal Instrument and Imaging Results." Otolaryngology–Head and Neck Surgery 163, no. 5 (2020): 1044–54. http://dx.doi.org/10.1177/0194599820926129.
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Objective: To determine whether psychological status is an effect modifier of the previously observed low discriminatory capacity of Sinonasal Outcome Test-22 (SNOT-22) scores for Lund-Mackay computed tomography (CT) results. Study Design: Observational outcomes study. Setting: Tertiary care center. Subjects and Methods: We assessed patients presenting with chronic sinonasal complaints who underwent CT of the sinuses within 1 month of completing the SNOT-22 instrument. SNOT-22 overall and domain scores were calculated, as were Lund-Mackay CT scores. The discriminatory capacity of SNOT-22 scores for CT results was determined using the receiver-operator characteristic area under the curve (ROC-AUC). Patient-Reported Outcome Measurement Information System (PROMIS) mental health T-scores were assessed, and stratified analyses were used to test for effect modification by psychological status. Results: In stratified analyses, patients with better PROMIS mental health scores had SNOT-22 overall (ROC-AUC 0.96) and nasal domain scores (ROC-AUC 0.97-0.98) that were highly discriminatory for Lund-Mackay scores, while those with worse mental health scores did not (ROC-AUC 0.42-0.55, P < .007). Patients with better SNOT-22 psychological domain scores also had nasal scores that discriminated among CT results significantly better than those with worse psychological domain scores (ROC-AUC 0.65-0.69 and 0.34-0.35, respectively, P < .013). Conclusions: Psychological status is an effect modifier of the relationship between SNOT-22 and Lund-Mackay scores. SNOT-22 scores were discriminatory for Lund-Mackay CT results in patients with better psychological status, while they were nondiscriminatory in those with worse psychological status. When assessing the relationship between subjective and objective measures of chronic rhinosinusitis, accounting for effect modification may have practical utility.
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Goodson, A., A. L. Poirrier, S. Ahluwalia, M. Bentley, and P. Andrews. "Sino-Nasal Outcome Test (SNOT-22) in septorhinoplasty: a useful outcome measure?" British Journal of Oral and Maxillofacial Surgery 50 (June 2012): S52. http://dx.doi.org/10.1016/j.bjoms.2012.04.105.
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Berrettini, Stefano, Francesca Forli, Gabriele Siciliano, and Michelangelo Mancuso. "Sudden bilateral hearing loss and sporadic mitochondrial DNA deletion." Journal of Laryngology & Otology 115, no. 2 (2001): 128–31. http://dx.doi.org/10.1258/0022215011907514.
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Abstract Several studies have indicated that a number of different mitochondrial DNA (mtDNA) mutations may be responsible for human pathologies. Sensorineural Hearing Loss (SNHL) may be associated with known syndromes (syndromal SNHL) or represent the only manifestation of mitochondrial damage (non-syndromal hearing loss). Moreover, mtDNA alterations may be responsible for aminoglycoside-induced deafness.We describe a patient harbouring a single sporadic mtDNA deletion, who presented with sudden adult-onset bilateral, although non-simultaneous SNHL, that was partially responsive to corticosteroids. Increased values of rest, and exercise, blood lactic acid were decisive for diagnosis, prompting muscle biopsy that revealed the mtDNA deletion. The case underscores the importance of investigating a mitochondrial disease in cases of SNHL of unknown origin and points out the importance of an increased blood level of lactic acid as a screening test.
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Guglielminotti, Jean, Nicolas Grillot, Marine Paule, et al. "Prediction of Movement to Surgical Stimulation by the Pupillary Dilatation Reflex Amplitude Evoked by a Standardized Noxious Test." Anesthesiology 122, no. 5 (2015): 985–93. http://dx.doi.org/10.1097/aln.0000000000000624.
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Abstract Background: Individual assessment of the amplitude of a physiologic reflex evoked by a standardized noxious test (SNT) before surgical stimulation has been suggested to predict movement upon the forthcoming surgical stimulation. This study aimed to compare the ability of pupillary dilatation reflex amplitude (PDRA) evoked by an SNT and estimated remifentanil effect-site concentration (Ce) to predict movement upon surgical stimulation. Methods: Eighty female patients were anesthetized for vacuum aspiration with propofol (Ce 4 μg/ml) and remifentanil. Remifentanil Ce was randomized to 0, 1, 3, or 5 ng/ml. SNT was a 60-mA, 5-s, 100-Hz tetanus applied on median nerve before cervix dilatation. PDRA was calculated as the difference in pupillary diameter after and before SNT. Movement upon cervix dilatation was recorded by an independent observer. Ability of PDRA and estimated remifentanil Ce to discriminate movers from non-movers during cervix dilatation was measured as the area under the receiver operating characteristics curve. Results: Twenty-one of the 76 patients analyzed moved during cervix dilatation. Mean PDRA (±1 SD) evoked by SNT was 2.0 ± 1.2 mm in movers and 0.6 ± 0.7 in non-movers (P &lt; 0.0001). Remifentanil Ce was 0.2 ± 0.4 ng/ml in movers and 3.0 ± 1.7 in non-movers (P &lt; 0.0001). Area under the receiver operating characteristics curve for PDRA was 0.90 (95% CI, 0.83 to 0.96) and for remifentanil Ce 0.94 (0.89 to 0.98), without any significant difference between the two areas. Conclusions: PDRA evoked by an SNT is as accurate as the estimated remifentanil Ce to predict movement upon cervix dilatation. PDRA could be valuable when estimated opioid Ce is not available or reliable.
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Brook, Christopher D., Alice Z. Maxfield, Hena Ahmed, Ahmad R. Sedaghat, Eric H. Holbrook, and Stacey T. Gray. "Factors Influencing the Need for Endoscopic Sinus Surgery in Adult Patients with Cystic Fibrosis." American Journal of Rhinology & Allergy 31, no. 1 (2017): 44–47. http://dx.doi.org/10.2500/ajra.2017.31.4385.
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Background Risk factors in adult patients with cystic fibrosis (CF) associated with surgical intervention have not been delineated. Objective To identify characteristics of adult patients with CF and with chronic rhinosinusitis that predict surgical intervention with endoscopic sinus surgery (ESS). Methods Patients were identified in a tertiary sinus center by the International Classification of Diseases, Ninth Revision codes 277.00-277.03, which represent CF. Charts were reviewed for the CF transmembrane conductance regulator (CFTR) gene mutation, Lund-Mackay score (LMS), the 22-item Sino-Nasal Outcome Test (SNOT-22) score, previous ESS, and occurrence of ESS after presentation. The Fisher exact test was used to test frequency of events between the groups, and the Mann Whitney U test and the t-test were used to compare means among LMS, SNOT-22, and age. The Cox proportional hazard analysis was used to calculate hazard ratios (HR) for the impact of LMS, SNOT-22 score, previous ESS, and CFTR gene mutation status on the occurrence of ESS after presentation. Results One hundred and fifteen patients met the inclusion criteria for the study. Patients with a history of surgery more often underwent ESS after presentation (p ≤ 0.01). The LMS and the SNOT-22 score were not significantly different between the groups of previous ESS and no previous ESS (p = 0.23 and p = 0.28, respectively). A severe mutation genotype was predictive of ESS after presentation (p = 0.03). SNOT-22 scores did not differ between the severe and mild groups (36.0 and 32.4, respectively; p = 0.57), but the mean LMS was significantly higher in the severe mutation group (12.5 and 9.7; p ≤ 0.01). Univariate Cox proportional hazard analysis revealed an increased occurrence of ESS for patients with severe mutations (HR, 3.6; p ≤ 0.01) or a history of ESS (HR, 2.3; p ≤ 0.01). Conclusion The occurrence of ESS in adult patients with CF was predicted by previous ESS intervention as well as the severity of CFTR mutation.
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Rahmawati, Rani. "Correlation : Anatomical Variations of Nasal Cavity and Paranasal Sinuses and the Quality of Life Based on SNOTT-22 Score." Saintika Medika 17, no. 1 (2021): 49–60. http://dx.doi.org/10.22219/sm.vol17.smumm1.13763.
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This study aims to determine the correlation between the anatomical variations of nasal cavity and paranasal sinuses and the quality of life based on SNOT-22 score in the patients who underwent paranasal sinuses CT scan. The samples are 36 patients with age ≥ 18 years. The method is Chi Square test / Fisher's test and Spearman’s rho test. The results showed that anatomical variations of the nasal cavity and paranasal sinuses from most of the patients who underwent paranasal sinuses CT scan had septal deviation n = 29, p = 0.007 (p <0.05) and concha bullosa n = 15, p = 0.029 (p <0.05). There was a significant correlation between total anatomical variation and quality of life based on SNOT-22 score in the patients who underwent paranasal sinuses CT scan p = 0.025 (p <0.05). There was no correlation between the anatomical variations of frontal cells, agger nasi cells, ethmoid bulla, uncinate process and haller cells and the quality of life based on SNOT-22 score in the patients who underwent paranasal sinuses CT scan.
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Wang, J. A., and K. C. Liu. "A New Approach to Evaluate Fracture Toughness of Structural Materials." Journal of Pressure Vessel Technology 126, no. 4 (2004): 534–40. http://dx.doi.org/10.1115/1.1804202.
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A new method, designated as Spiral Notch Torsion Test (SNTT), is developed recently to measure the intrinsic fracture toughness KIC of structural materials. The SNTT overcomes many of the limitations inherent in traditional techniques and makes it possible to standardize fracture toughness testing. It is uniquely suitable for testing a wide variety of materials used extensively in pressure vessel and piping structural components and weldments, including others such as ceramics, their composites, and concrete. The SNTT system operates by applying pure torsion to uniform cylindrical specimens with a notch line that spirals around the specimen at a 45 deg pitch. The KIC values are obtained with the aid of a three-dimensional finite-element computer code, TOR3D-KIC, developed at Oak Ridge National Laboratory (ORNL). The fundamental mechanism of SNTT approach is also described in the paper.
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Simuntis, Regimantas, Justinas Vaitkus, Ričardas Kubilius, et al. "Comparison of Sino-Nasal Outcome Test 22 Symptom Scores in Rhinogenic and Odontogenic Sinusitis." American Journal of Rhinology & Allergy 33, no. 1 (2018): 44–50. http://dx.doi.org/10.1177/1945892418804975.
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Background Odontogenic maxillary sinusitis (OMS) and rhinogenic sinusitis (RS) are the main types of chronic rhinosinusitis (CRS) and have a significant impact on health-related quality of life (HRQL), but the difference in HRQL and symptom presentation between them has not been specifically evaluated to date. Obejctive: Our aim was to compare patterns of symptoms and HRQL disease-specific domains in patients affected with these 2 types of CRS. Methods A group of 201 patients with CRS (99 with rhinogenic and 102 with odontogenic origin) completed the Sino-Nasal Outcome Test 22 (SNOT-22) questionnaire before treatment. Data sets were analyzed by using principal component analysis (PCA) to identify a set of symptom components together with the items excluded from PCA, which were then analyzed for differences between patients with OMS and RS. Results PCA of SNOT-22 items identified 5 components: “rhinologic,” “extranasal rhinologic,” “ear/facial,” “sleep and functional disturbance,” and “emotional disturbance.” Sneezing was excluded from PCA and treated as separate outcome variable and was significantly worse in RS patients. Patients with OMS scored significantly higher scores with regard to emotional disturbance, while RS patients scored significantly worse in sleep and functional disturbance. The extra symptom “malodor” was the most different symptom and was significantly worse in OMS patients. The total SNOT-22 score was not significantly different between the groups. Conclusion With controlling of covariates that may influence the severity of the disease, this study showed some significant differences in symptom patterns and HRQL impairment between patients with OMS and RS. Malodor is the most characteristic feature of OMS. Therefore, OMS should always be suspected in patients complaining of bad breath.
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Christidi, Foteini, Ioannis Zalonis, Nikolaos Smyrnis, and Ioannis Evdokimidis. "Selective Attention and the Three-Process Memory Model for the Interpretation of Verbal Free Recall in Amyotrophic Lateral Sclerosis." Journal of the International Neuropsychological Society 18, no. 5 (2012): 809–18. http://dx.doi.org/10.1017/s1355617712000562.
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AbstractThe present study investigates selective attention and verbal free recall in amyotrophic lateral sclerosis (ALS) and examines the contribution of selective attention, encoding, consolidation, and retrieval memory processes to patients’ verbal free recall. We examined 22 non-demented patients with sporadic ALS and 22 demographically related controls using Stroop Neuropsychological Screening Test (SNST; selective attention) and Rey Auditory Verbal Learning Test (RAVLT; immediate & delayed verbal free recall). The item-specific deficit approach (ISDA) was applied to RAVLT to evaluate encoding, consolidation, and retrieval difficulties. ALS patients performed worse than controls on SNST (p < .001) and RAVLT immediate and delayed recall (p < .001) and showed deficient encoding (p = .001) and consolidation (p = .002) but not retrieval (p = .405). Hierarchical regression analysis revealed that SNST and ISDA indices accounted for: (a) 91.1% of the variance in RAVLT immediate recall, with encoding (p = .016), consolidation (p < .001), and retrieval (p = .032) significantly contributing to the overall model and the SNST alone accounting for 41.6%; and (b) 85.2% of the variance in RAVLT delayed recall, with consolidation (p < .001) and retrieval (p = .008) significantly contributing to the overall model and the SNST alone accounting for 39.8%. Thus, selective attention, encoding, and consolidation, and to a lesser extent of retrieval, influenced both immediate and delayed verbal free recall. Concluding, selective attention and the memory processes of encoding, consolidation, and retrieval should be considered while interpreting patients’ impaired free recall. (JINS, 2012, 18, 1–10)
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Choi, Kevin J., Feras Y. Ackall, Tracy Truong, et al. "Sinonasal Quality of Life Outcomes After Extended Endonasal Approaches to the Skull Base." Journal of Neurological Surgery Part B: Skull Base 80, no. 04 (2018): 416–23. http://dx.doi.org/10.1055/s-0038-1675592.
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Introduction Endoscopic endonasal skull base surgery (EESBS) leads to significant alterations in sinonasal anatomy and physiology. However, there is limited data available on quality of life (QOL) outcomes following EESBS. Methods A retrospective review of patients undergoing EESBS from January 2014 to April 2017 was performed. Records were reviewed for clinical history, operative details, and 22-item Sinonasal Outcomes Test (SNOT-22) scores. Unadjusted and adjusted linear regression models were utilized to compare change in SNOT-22 scores from baseline in patients who underwent a simple sella approach (SA) or an extended beyond sella approach (BSA). Results A total of 108 patients were in the SA group, while 61 patients were in the BSA group. SNOT-22 scores were available at baseline and 3 months for 84 patients, while 6-month scores were available for 49 patients. SNOT-22 scores for all patients were not significantly different at 3 months (p = 0.40) or at 6 months (p = 0.58). Unadjusted linear regression model did not show an association between the type of approach and change in SNOT-22 score at 3 months (p = 0.07) and 6 months (p = 0.28). Adjusted regression model showed a significant decrease in SNOT-22 scores at 3 months (p = 0.04) for the BSA group, but there was no significant change in SNOT-22 score at 6 months (p = 0.22). Conclusion Patients undergoing EESBS had no significant change in outcomes at 3 and 6 months. A more extensive BSA was not associated with worse QOL outcomes as measured by SNOT-22.
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Ogino-Nishimura, Eriko, Shinya Hiroshiba, and Michitaka Iwanaga. "Reliability, Validity and Responsiveness of the Sino-Nasal Outcome Test (SNOT-22) in Japanese Patients." Nippon Jibiinkoka Gakkai Kaiho 120, no. 9 (2017): 1155–64. http://dx.doi.org/10.3950/jibiinkoka.120.1155.
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Ylivuori, Maija, Reija Ruuhela, Harri Sintonen, Paula Virkkula, Risto P. Roine, and Maija Hytönen. "Seasonal Variation in Generic and Disease-Specific Health-Related Quality of Life in Rhinologic Patients in Southern Finland." International Journal of Environmental Research and Public Health 18, no. 12 (2021): 6428. http://dx.doi.org/10.3390/ijerph18126428.
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Background: Seasonal variation in exacerbations, hospitalisations, and mortality statistics has been reported for some diseases. To our knowledge, however, no published studies exist on the seasonality of health-related quality of life (HRQoL) amongst rhinologic patients. Aims/Objectives: This study, therefore, aimed to investigate the possible seasonal variation in rhinologic patients’ HRQoL using the rhinologic disease-specific Sino-Nasal Outcome Test-22 (SNOT-22) and the generic 15D HRQoL instrument. Material and Methods: We enrolled unselected adult rhinologic patients requiring specialist care at the Helsinki University Hospital in this cross-sectional, questionnaire-based prospective study during four seasons: February (winter), May (spring), August (summer), and November (autumn). Patients received SNOT-22 and 15D questionnaires via post. The Finnish Meteorological Institute supplied climate data from these months. Results: SNOT-22 and 15D data were available for 301 and 298 patients, respectively. We found no statistically significant differences (p = 0.948) between the mean monthly 15D scores or mean SNOT-22 scales. Furthermore, the mean SNOT-22 subscales did not differ between the monthly study periods. Conclusions and Significance: Our study shows that seasonality did not impact rhinologic patients’ SNOT-22 or 15D HRQoL scores. Thus, these questionnaires can be used for follow-up amongst rhinologic patients regardless of season.
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Gadag, Raveendra P., Puneeth S. Nayak, and Tejaswini J. "Clinical Asssessment of Sensorineural Hearing Loss among Diabetes Mellitus Patients." Bengal Journal of Otolaryngology and Head Neck Surgery 28, no. 2 (2020): 112–19. http://dx.doi.org/10.47210/bjohns.2020.v28i2.297.
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Background: Hearing impairment is known to hamper the quality of life among patients, especially among diabetics due to the association of neuropathy with diabetes. However, the prevalence and degree of the SNHL depends upon different factors, such as age, gender, disease duration of DM, family history and glycemic status of the patients. Therefore, this study aimed to assess the association of SNHL with DM duration and familial DM and gender preponderance among SNHL–DM patients.
 Methods: Total 140 patients with DM were assessed for hearing impairment using Rinne, Weber and Absolute Bone Conduction Tests along with pure tone audiometry. Patients’ glycaemic status was determined by estimating fasting blood glucose (FBG) and post prandial blood glucose (PPBG) levels. Independent t-test, chi-square, ANOVA and Pearson’s correlation tests along with linear regression model were used to find association and correlation using R software.
 Results: Out of 140 patients, 60 were suffering from SNHL and majority were suffering from bilateral minimal hearing loss. SNHL was significantly associated with family history, age, duration of DM, FBG and PPBG levels were(Pvalues:1.79E08, 4.41E-06 and 0.02), however, significant correlated with duration of DM, FBS and PPBG level (r value:0.14–0.41).Furthermore, significant SNHL at 500 and 8000Hz was observed in the present study (Pvalue:0.002).
 Conclusion: A conclusive proof was drawn that family history of DM serve as a valuable variable in assessing the SNHL among DM patients.
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Brown, Hannah J., Hannah N. Kuhar, Max A. Plitt, Inna Husain, Pete S. Batra, and Bobby A. Tajudeen. "The Impact of Laryngopharyngeal Reflux on Patient-reported Measures of Chronic Rhinosinusitis." Annals of Otology, Rhinology & Laryngology 129, no. 9 (2020): 886–93. http://dx.doi.org/10.1177/0003489420921424.
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Objective: This study explored the impact of laryngopharyngeal reflux (LPR) on quality-of-life outcomes captured by Sino-Nasal Outcome Test (SNOT-22) and Reflux Symptom Index (RSI) in patients with chronic rhinosinusitis (CRS) and patients with symptoms of LPR. Methods: In a retrospective chart review, SNOT-22 and RSI scores were analyzed in patients seen at a tertiary care center with CRS, LPR, or both CRS and LPR. SNOT-22 items were grouped into sleep, nasal, otologic, and emotional symptom subdomains. Results: A total of 138 patients (36 with CRS alone, 60 with LPR alone, and 42 with both CRS and LPR) were included. Compared to patients with CRS alone, those with CRS and LPR (CRS+LPR) had higher SNOT-22 total (50.54 ± 19.53 vs 35.31 ± 20.20, P < .001), sleep (19.61 ± 9.31 vs 14.42 ± 10.34, P < .022), nasal (17.38 ± 7.49 vs 11.11 ± 8.52, P < .001), otologic subdomains (9.17 ± 5.07 vs 5.53 ± 5.14, P < .002), and RSI (22.06 ± 9.42 vs 10.75 ± 8.43, P < .003). Patients with LPR alone had higher RSI compared to those with CRS (18.48 ± 9.77 vs 10.75 ± 8.43, P < .037). RSI and SNOT-22 scores were positively correlated irrespective of patient group (R = 0.289, P = .003). Conclusion: Compared to patients with CRS or LPR alone, those with CRS+LPR demonstrated higher RSI and total and subdomain SNOT-22 scores. Patients with LPR alone had elevated SNOT-22 despite absent endoscopic evidence of sinusitis.
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Le, Phong T., Zachary M. Soler, Rabun Jones, Jose L. Mattos, Shaun A. Nguyen, and Rodney J. Schlosser. "Systematic Review and Meta-analysis of SNOT-22 Outcomes after Surgery for Chronic Rhinosinusitis with Nasal Polyposis." Otolaryngology–Head and Neck Surgery 159, no. 3 (2018): 414–23. http://dx.doi.org/10.1177/0194599818773065.
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Objective Wide variation exists regarding reported outcomes after endoscopic sinus surgery (ESS) for chronic rhinosinusitis with nasal polyps (CRSwNP). This study seeks to combine data across studies to generate a summary measure and explore factors that might lead to variation. Data Sources OVID Medline, Scopus, EbscoHost, Database of Abstracts and Reviews of Effects, Health Technology Assessment, and National Health Service Economic Evaluation Database. Review Methods A search was performed following the PRISMA guidelines. Two independent researchers conducted a search using the mentioned data sources. Studies published before August 29, 2016, that involved ESS to treat CRSwNP were included. Mean changes in Sinonasal Outcome Test–22 (SNOT-22) scores were determined through metaregression of the following independent variables: publication year, sex, age, allergy status, asthma, tobacco use, prior surgery, follow-up length, and preoperative SNOT-22. Results Fifteen articles with 3048 patients treated with ESS met inclusion criteria. Pooled analyses of SNOT-22 scores revealed a mean change of 23.0 points (95% CI, 20.2-25.8; P < .001). A metaregression of patient factor effects on the mean change of SNOT-22 scores demonstrated that age ( r = 0.71, P = .01), asthma ( r = 0.21, P = .01), prior ESS ( r = 0.29, P = .01), and preoperative SNOT-22 score ( r = 0.4, P < .01) correlated with greater improvement in SNOT-22 scores. Tobacco use ( r = −0.91, P = .01) and longer lengths of follow-up ( r = −0.45, P < .01) were associated with less improvement in SNOT-22 scores. Conclusions Quality-of-life outcomes are significantly improved after ESS among patients with CRSwNP. Patient-specific factors may affect the degree of SNOT-22 change after surgery.