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Journal articles on the topic 'Sodium (23Na) Magnetic Resonance Imaging (MRI)'

Author: Grafiati

Published: 14 March 2023

Last updated: 19 July 2025

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1

Akbari, Alireza, and Christopher W. McIntyre. "Recent Advances in Sodium Magnetic Resonance Imaging and Its Future Role in Kidney Disease." Journal of Clinical Medicine 12, no. 13 (2023): 4381. http://dx.doi.org/10.3390/jcm12134381.

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Sodium imbalance is a hallmark of chronic kidney disease (CKD). Excess tissue sodium in CKD is associated with hypertension, inflammation, and cardiorenal disease. Sodium magnetic resonance imaging (23Na MRI) has been increasingly utilized in CKD clinical trials especially in the past few years. These studies have demonstrated the association of excess sodium tissue accumulation with declining renal function across whole CKD spectrum (early- to end-stage), biomarkers of systemic inflammation, and cardiovascular dysfunction. In this article, we review recent advances of 23Na MRI in CKD and disc

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Giovannetti, Giulio, Alessandra Flori, Nicola Martini, et al. "Hardware and Software Setup for Quantitative 23Na Magnetic Resonance Imaging at 3T: A Phantom Study." Sensors 24, no. 9 (2024): 2716. http://dx.doi.org/10.3390/s24092716.

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Magnetic resonance (MR) with sodium (23Na) is a noninvasive tool providing quantitative biochemical information regarding physiology, cellular metabolism, and viability, with the potential to extend MR beyond anatomical proton imaging. However, when using clinical scanners, the low detectable 23Na signal and the low 23Na gyromagnetic ratio require the design of dedicated radiofrequency (RF) coils tuned to the 23Na Larmor frequency and sequences, as well as the development of dedicated phantoms for testing the image quality, and an MR scanner with multinuclear spectroscopy (MNS) capabilities. I

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Giovannetti, Giulio, Alessandra Flori, Nicola Martini, et al. "Sodium Radiofrequency Coils for Magnetic Resonance: From Design to Applications." Electronics 10, no. 15 (2021): 1788. http://dx.doi.org/10.3390/electronics10151788.

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Sodium (23Na) is the most abundant cation present in the human body and is involved in a large number of vital body functions. In the last few years, the interest in Sodium Magnetic Resonance Imaging (23Na MRI) has considerably increased for its relevance in physiological and physiopathological aspects. Indeed, sodium MRI offers the possibility to extend the anatomical imaging information by providing additional and complementary information on physiology and cellular metabolism with the heteronuclear Magnetic Resonance Spectroscopy (MRS). Constraints are the rapidly decaying of sodium signal,

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Kamp, Benedikt, Miriam Frenken, Lena Klein-Schmeink, et al. "Evaluation of Sodium Relaxation Times and Concentrations in the Achilles Tendon Using MRI." International Journal of Molecular Sciences 23, no. 18 (2022): 10890. http://dx.doi.org/10.3390/ijms231810890.

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Sodium magnetic resonance imaging (MRI) can be used to evaluate the change in the proteoglycan content in Achilles tendons (ATs) of patients with different AT pathologies by measuring the 23Na signal-to-noise ratio (SNR). As 23Na SNR alone is difficult to compare between different studies, because of the high influence of hardware configurations and sequence settings on the SNR, we further set out to measure the apparent tissue sodium content (aTSC) in the AT as a better comparable parameter. Ten healthy controls and one patient with tendinopathy in the AT were examined using a clinical 3 Tesl

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Atthe, Bharath K., Andriy M. Babsky, Paige N. Hopewell, Carrie L. Phillips, Bruce A. Molitoris, and Navin Bansal. "Early monitoring of acute tubular necrosis in the rat kidney by 23Na-MRI." American Journal of Physiology-Renal Physiology 297, no. 5 (2009): F1288—F1298. http://dx.doi.org/10.1152/ajprenal.00388.2009.

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Reabsorption of water and other molecules is dependent on the corticomedullary sodium concentration gradient in the kidney. During the early course of acute tubular necrosis (ATN), this gradient is altered. Therefore, 23Na magnetic resonance imaging (MRI) was used to study the alterations in renal sodium distribution in the rat kidney during ischemia and reperfusion (IR) injury, which induces ATN. In-magnet ischemia was induced for 0 (control), 10, 20, 30 or 50 min in Wistar rats. 23Na images were collected every 10 min during baseline, ischemia, and 60-min reperfusion periods. T1 and T2 relax

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Moosmann, Julia, Okan Toka, Peter Linz, et al. "Tolvaptan treatment in an adult Fontan patient with protein-losing enteropathy: a serial 23Na-MRI investigation." Therapeutic Advances in Chronic Disease 12 (January 2021): 204062232110040. http://dx.doi.org/10.1177/20406223211004005.

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Background: Protein-losing enteropathy (PLE) is a severe complication of the univentricular Fontan circulation and associated with disturbances in salt and water homeostasis. Fontan patients with PLE have a poor prognosis, with increased morbidity and mortality. Due to limited therapeutic strategies, patients are often treated only symptomatically. Methods: We report our first experience of Tolvaptan (TLV) treatment in a Fontan patient with PLE, severe volume retention and hyponatraemia, refractory to conventional diuretic therapy. In addition to clinical parameters, we monitored drug effects

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Sadykhov, E. G., Yu A. Pirogov, N. V. Anisimov, et al. "Magnetic Resonance Imaging on Sodium Nuclei: Potential Medical Applications of 23Na MRI." Applied Magnetic Resonance 49, no. 9 (2018): 925–57. http://dx.doi.org/10.1007/s00723-018-1045-7.

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8

Ruder, Arne Mathias, Sherif A. Mohamed, Michaela A. U. Hoesl, et al. "Radiosurgery-induced early changes in peritumoral tissue sodium concentration of brain metastases." PLOS ONE 19, no. 11 (2024): e0313199. http://dx.doi.org/10.1371/journal.pone.0313199.

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Background Stereotactic radiosurgery (SRS) is an effective therapy for brain metastases. Response is assessed with serial 1H magnetic resonance imaging (MRI). Early markers for response are desirable to allow for individualized treatment adaption. Previous studies indicated that radiotherapy might have impact on tissue sodium concentration. Thus, 23Na MRI could provide early quantification of response to SRS. Purpose We investigated whether longitudinal detection of tissue sodium concentration alteration within brain metastases and their peritumoral tissue after SRS with 23Na MRI was feasible.

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9

Perelman, Adi, Naftali Lazarovitch, Jan Vanderborght, and Andreas Pohlmeier. "Quantitative imaging of sodium concentrations in soil-root systems using magnetic resonance imaging (MRI)." Plant and Soil 454, no. 1-2 (2020): 171–85. http://dx.doi.org/10.1007/s11104-020-04628-8.

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Abstract Aims Demonstrating the potential of MRI as a 3D, non-invasive and continuous measurement technique to map Na+ concentration distributions in soil and around roots. Methods Dissolved NaCl in soil and soil-plant systems was mapped by 3D 23Na-MRI. The lower limit of detectability in saturated and unsaturated porous media was evaluated, followed by evaporation experiments to test the quantification. Finally, Na+ enrichment around tomato roots, irrigated with saline solution under low/high transpiration rates (LT, HT), was imaged in parallel to the root system,. Results A spin echo pulse s

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Eisele, Philipp, Simon Konstandin, Martin Griebe, et al. "Heterogeneity of acute multiple sclerosis lesions on sodium (23Na) MRI." Multiple Sclerosis Journal 22, no. 8 (2015): 1040–47. http://dx.doi.org/10.1177/1352458515609430.

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Background: Advanced magnetic resonance imaging (MRI) techniques provide a window into pathological processes in multiple sclerosis (MS). Nevertheless, to date only few studies have performed sodium MRI in MS. Objectives: We analysed total sodium concentration (TSC) in hyperacute, acute and chronic lesions in MS with 23Na MRI. Methods: 23Na MRI and 1H MRI were performed in 65 MS patients and 10 healthy controls (HC). Mean TSC was quantified in all MS lesions with a diameter of >5 mm and in the normal appearing white and grey matter (NAWM, NAGM). Results: TSC in the NAWM and the NAGM of MS p

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Ronga, Mario, Gloria Angeretti, Sergio Ferraro, Giovanni De Falco, Eugenio Genovese, and Paolo Cherubino. "Imaging of articular cartilage: current concepts." Joints 02, no. 03 (2014): 137–40. http://dx.doi.org/10.11138/jts/2014.2.3.137.

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Magnetic resonance imaging (MRI) is the gold standard method for non-invasive assessment of joint cartilage, providing information on the structure, morphology and molecular composition of this tissue. There are certain minimum requirements for a MRI study of cartilage tissue: machines with a high magnetic field (> 1.5 Tesla); the use of surface coils; and the use of T2-weighted, proton density-weighted fast-spin echo (T2 FSE-DP) and 3D fat-suppressed T1-weighted gradient echo (3D-FS T1W GRE) sequences. For better contrast between the different joint structures, MR arthography is a method t

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Guiheneuf, Thierry M., Stephen J. Gibbs, and Laurance D. Hall. "Measurement of the inter-diffusion of sodium ions during pork brining by one-dimensional 23Na Magnetic Resonance Imaging (MRI)." Journal of Food Engineering 31, no. 4 (1997): 457–71. http://dx.doi.org/10.1016/s0260-8774(96)00085-4.

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Eleff, Scott M., Mitchell D. Schnall, Laszlo Ligetti, et al. "Concurrent measurements of cerebral blood flow, sodium, lactate, and high-energy phosphate metabolism using19F,23Na,1H, and31P nuclear magnetic resonance spectroscopy." Magnetic Resonance in Medicine 7, no. 4 (1988): 412–24. http://dx.doi.org/10.1002/mrm.1910070404.

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14

Puder, Lia, Sophie Roth, Philipp Krabusch, et al. "Cardiac Phenotype and Tissue Sodium Content in Adolescents With Defects in the Melanocortin System." Journal of Clinical Endocrinology & Metabolism 106, no. 9 (2021): 2606–16. http://dx.doi.org/10.1210/clinem/dgab368.

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Abstract Context Pro-opiomelanocortin (POMC) and the melanocortin-4 receptor (MC4R) play a pivotal role in the leptin–melanocortin pathway. Mutations in these genes lead to monogenic types of obesity due to severe hyperphagia. In addition to dietary-induced obesity, a cardiac phenotype without hypertrophy has been identified in MC4R knockout mice. Objective We aimed to characterize cardiac morphology and function as well as tissue Na+ content in humans with mutations in POMC and MC4R genes. Methods A cohort of 42 patients (5 patients with bi-allelic POMC mutations, 6 heterozygous MC4R mutation

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15

Wolff, S. D., J. Eng, B. A. Berkowitz, S. James, and R. S. Balaban. "Sodium-23 nuclear magnetic resonance imaging of the rabbit kidney in vivo." American Journal of Physiology-Renal Physiology 258, no. 4 (1990): F1125—F1131. http://dx.doi.org/10.1152/ajprenal.1990.258.4.f1125.

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The mechanism by which the mammalian kidney generates a concentration gradient of sodium from cortex to papilla is still not entirely understood. Studies of how the kidney as an organ generates this gradient have been hampered by the lack of a noninvasive method for monitoring the intrarenal sodium distribution. Herein, we demonstrate the value of sodium-23 nuclear magnetic resonance (23Na-NMR) imaging to nondestructively assess the intrarenal sodium distribution. 23Na-NMR images were obtained from a surgically exposed kidney preparation that showed the two-dimensional distribution of sodium i

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Nielsen, Per Mose, Christian Østergaard Mariager, Daniel Guldager Kring Rasmussen, et al. "Noninvasive Assessment of Fibrosis Following Ischemia/Reperfusion Injury in Rodents Utilizing Na Magnetic Resonance Imaging." Pharmaceutics 12, no. 8 (2020): 775. http://dx.doi.org/10.3390/pharmaceutics12080775.

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Fibrosis is often heterogeneously distributed, and classical biopsies do not reflect this. Noninvasive methods for renal fibrosis have been developed to follow chronic kidney diseases (CKD) and to monitor anti-fibrotic therapy. In this study, we combined two approaches to assess fibrosis regression following renal ischemia-reperfusion injury (IRI): magnetic resonance imaging (MRI) and noninvasive extracellular matrix (ECM) biomarkers. MRI was used to evaluate fibrosis in bilateral IRI in rats after reperfusion at 7, 14, and 21 days. This was performed with 1HT1 and T2* mapping, dynamic contras

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Christa, Martin, Andreas M. Weng, Bettina Geier, et al. "Increased myocardial sodium signal intensity in Conn’s syndrome detected by 23Na magnetic resonance imaging." European Heart Journal - Cardiovascular Imaging 20, no. 3 (2018): 263–70. http://dx.doi.org/10.1093/ehjci/jey134.

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18

Meyer, Melissa M., Alexander Schmidt, Justus Benrath, et al. "Cerebral sodium (23Na) magnetic resonance imaging in patients with migraine — a case-control study." European Radiology 29, no. 12 (2019): 7055–62. http://dx.doi.org/10.1007/s00330-019-06299-1.

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19

Allen, K. L., A. L. Busza, S. R. Williams, and S. R. Williams. "Early changes in cerebral sodium distribution following ischaemia monitored by 23Na magnetic resonance imaging." Magnetic Resonance Imaging 12, no. 6 (1994): 895–900. http://dx.doi.org/10.1016/0730-725x(94)92030-3.

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Yu, Zidan, Guillaume Madelin, Daniel K. Sodickson, and Martijn A. Cloos. "Simultaneous proton magnetic resonance fingerprinting and sodium MRI." Magnetic Resonance in Medicine 83, no. 6 (2019): 2232–42. http://dx.doi.org/10.1002/mrm.28073.

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Burge, Alissa, Hollis Potter, and Erin Argentieri. "Magnetic Resonance Imaging of Articular Cartilage within the Knee." Journal of Knee Surgery 31, no. 02 (2018): 155–65. http://dx.doi.org/10.1055/s-0037-1620233.

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AbstractMagnetic resonance imaging (MRI) provides an effective and noninvasive means by which to evaluate articular cartilage within the knee. Existing techniques can be utilized to detect and monitor longitudinal changes in cartilage status due to injury or progression of degenerative disease. Quantitative MRI (qMRI) techniques can provide a metric by which to evaluate the efficacy of cartilage repair techniques and offer insight into the composition of cartilage and cartilage repair tissue. In this review, we provide background on MR signal generation and decay, the utility of morphologic MR

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Hernandez, Daniel. "Design of a Coplanar Interlayer Gapped Microstrips Arrangement for Multi-Nuclei (1H, 19F, 31P, and 23Na) Applications in 7T MRI." Applied Sciences 11, no. 3 (2021): 957. http://dx.doi.org/10.3390/app11030957.

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Seven Tesla Magnetic Resonance (MR) systems can obtain high quality anatomical images using protons (1H) and can be used for multinuclear imaging and MR spectroscopy. These imaging modes can also obtain images and metabolic information using other nuclei, such as 19F, 31P, and 23Na. Here, we present an RF coil unit using a microstrip capable of resonating at four frequencies: 300 (1H), 280 (19F), 121 (31P), and 78 (23Na) MHz. The RF unit consists of a single feeding port and four lines that resonate and run a current at their respective frequency. We used the gapped microstrip concept to isola

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Rotundo, Sabrina, Valeria Lazzoni, Alessandro Dellabate, Danilo Brizi, and Agostino Monorchio. "Dual-Tuned Magnetic Metasurface for Field Enhancement in 1H and 23Na 1.5 T MRI." Applied Sciences 15, no. 11 (2025): 5958. https://doi.org/10.3390/app15115958.

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In this paper, we present a novel passive dual-tuned magnetic metasurface, which can enhance the field distribution produced by a closely placed radio-frequency coil for both 1H and 23Na 1.5 T MRI imaging. In particular, the proposed solution comprises a 5 × 5 capacitively loaded array, in which each unit-cell is composed of two concentric spiral coils. Specifically, the unit-cell internal spiral coil operates at the proton Larmor frequency (64 MHz), whereas the external is at the sodium one (17 MHz). Therefore, the paper aims to demonstrate the possibility of enhancing the magnetic field dist

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Solomakha, G., N. Egorova, R. Balafendiev, C. Simovski, and S. Glybovski. "Wideband Coil Based on Microstrip Line for Multiheteronuclear Magnetic Resonance Spectroscopy." Journal of Physics: Conference Series 2015, no. 1 (2021): 012146. http://dx.doi.org/10.1088/1742-6596/2015/1/012146.

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Abstract Magnetic Resonance Spectroscopy of X-nucleus is a method for mapping metabolite quantity in-vivo in the desired region of the human body. However, this method has a lot of difficulties. Since natural abundance of X-nucleus is much lower than for hydrogen, to improve SNR of the spectrum we need to work in higher static magnetic fields. But, even at such high fields, X-nuclei imaging still a very difficult process. One of the problems are RF-coils, which are required for transmission and reception of signals. Traditionally, for human body X-nuclei MRS multi-tuned loop coils are used. Ho

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Matwiyoff, Nicholas A. "NMR imaging and spectroscopy of tissue at high resolution: problems and prospects." Proceedings, annual meeting, Electron Microscopy Society of America 44 (August 1986): 110–11. http://dx.doi.org/10.1017/s0424820100142190.

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When the nuclei of atoms like hydrogen (1H), carbon (13C), phosphorus (31P), and sodium (23Na) are subjected to a static magnetic field, they can be induced to emit electromagnetic radiation. This phenomenon, called nuclear magnetic resonance (NMR), was first demonstrated experimentally by the research groups of Bloch and Purcell in 1946. Because the spectrum of the radiation emitted depends on the type of nucleus and its chemical environment, NMR spectroscopy was rapidly exploited by chemists and has become a major tool for the investigation of molecular structure and the analysis of complex

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Strasser, Paul, Verena Schinegger, Joachim Friske, et al. "Superfluorinated, Highly Water-Soluble Polyphosphazenes as Potential 19F Magnetic Resonance Imaging (MRI) Contrast Agents." Journal of Functional Biomaterials 15, no. 2 (2024): 40. http://dx.doi.org/10.3390/jfb15020040.

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“Hot spot” 19F magnetic resonance imaging (MRI) has garnered significant attention recently for its ability to image various disease markers quantitatively. Unlike conventional gadolinium-based MRI contrast agents, which rely on proton signal modulation, 19F-MRI’s direct detection has a unique advantage in vivo, as the human body exhibits a negligible background 19F-signal. However, existing perfluorocarbon (PFC) or PFC-based contrast materials suffer from several limitations, including low longitudinal relaxation rates and relatively low imaging efficiency. Hence, we designed a macromolecular

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Wetterling, Friedrich, Lindsay Gallagher, Jim Mullin, et al. "Sodium-23 Magnetic Resonance Imaging Has Potential for Improving Penumbra Detection but Not for Estimating Stroke Onset Time." Journal of Cerebral Blood Flow & Metabolism 35, no. 1 (2014): 103–10. http://dx.doi.org/10.1038/jcbfm.2014.174.

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Tissue sodium concentration increases in irreversibly damaged (core) tissue following ischemic stroke and can potentially help to differentiate the core from the adjacent hypoperfused but viable penumbra. To test this, multinuclear hydrogen-1/sodium-23 magnetic resonance imaging (MRI) was used to measure the changing sodium signal and hydrogen-apparent diffusion coefficient (ADC) in the ischemic core and penumbra after rat middle cerebral artery occlusion (MCAO). Penumbra and core were defined from perfusion imaging and histologically defined irreversibly damaged tissue. The sodium signal in t

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Levytskyi, Yevhenii A., Olexandr А. Burianov, Taras M. Omelchenko, and Igor V. Ievsieienko. "MAGNETIC RESONANCE IMAGING DETERMINATION OF STRUCTURAL DISORDERS OF ARTICULAR CARTILAGE: MODERN DIAGNOSTIC TECHNOLOGIES AND RESEARCH PROSPECTS." Wiadomości Lekarskie 76, no. 4 (2023): 849–56. http://dx.doi.org/10.36740/wlek202304123.

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The aim: Tо present enhanced (with the contrast) and non-enhanced MRI techniques, provide an update on the physical principles of the main and latest techniques, and describe the advantages and disadvantages of each technique. The information obtained can provide an opportunity to diagnose changes at the structural level of the articular cartilage, thereby improving the early diagnosis of OA and optimizing the tactics of further treatment of patients. Materials and methods: We retrospectively reviewed publications published in the PubMed and Embase databases up to February 2023 using the follo

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Henderson, Luke A., Paul M. Macey, Chris A. Richard, Matthew L. Runquist, and Ronald M. Harper. "Functional magnetic resonance imaging during hypotension in the developing animal." Journal of Applied Physiology 97, no. 6 (2004): 2248–57. http://dx.doi.org/10.1152/japplphysiol.00297.2004.

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Hypotension in adult animals recruits brain sites extending from cerebellar cortex to the midbrain and forebrain, suggesting a range of motor and endocrine reactions to maintain perfusion. We hypothesized that comparable neural actions during development rely more extensively on localized medullary processes. We used functional MRI to assess neural responses during sodium nitroprusside challenges in 14 isoflurane-anesthetized kittens, aged 14–25 days, and seven adult cats. Baseline arterial pressure increased with age in kittens, and basal heart rates were higher. The magnitude of depressor re

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van Wesemael, T. J., E. C. de Moel, W. M. Teeuwisse, et al. "POS1386 INCREASED SODIUM ACCUMULATION IN INFLAMED KNEES OF PATIENTS WITH AUTOIMMUNE JOINT DISEASE DETECTED BY 23NA-MAGNETIC RESONANCE IMAGING." Annals of the Rheumatic Diseases 84 (June 2025): 1412. https://doi.org/10.1016/j.ard.2025.06.734.

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Juif, L., P. Calame, C. Chausset, et al. "P306 Efficacy and tolerance of sodium picosulfate preparation in bowel Magnetic Resonance Imaging in Crohn’s disease." Journal of Crohn's and Colitis 16, Supplement_1 (2022): i333—i334. http://dx.doi.org/10.1093/ecco-jcc/jjab232.433.

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Abstract Background Polyethylene glycol (PEG) is one of the most commonly used bowel preparation for magnetic resonance imaging (MRI) in Crohn’s Disease (CD). Sodium picosulfate (Pico) is a low volume bowel preparation known for its efficacy and higher tolerability for colonoscopy. No study has to date evaluated tolerance and efficacy of Pico preparations for MRI in CD. Aim: To assess for the first time the efficacy and tolerance of Pico preparation compared to PEG preparation for bowel MRI in CD. Methods The study took place in a French university hospital. To assess the efficacy of low volum

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Potter, Kimberlee, Bruce J. Balcom, T. Adrian Carpenter, and Laurance D. Hall. "The gelation of sodium alginate with calcium ions studied by magnetic resonance imaging (MRI)." Carbohydrate Research 257, no. 1 (1994): 117–26. http://dx.doi.org/10.1016/0008-6215(94)84112-8.

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Oei, Edwin, Marius Wick, Anja Müller-Lutz, Christoph Schleich, and Falk Miese. "Cartilage Imaging: Techniques and Developments." Seminars in Musculoskeletal Radiology 22, no. 02 (2018): 245–60. http://dx.doi.org/10.1055/s-0038-1639471.

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AbstractCartilage degeneration is one of the most common chronic age-related joint disorders leading to pain and reduced joint motion. The increasing prevalence of osteoarthritis requires accurate cartilage imaging, both clinically and in research. Detailed cartilage imaging is also necessary for traumatic cartilage lesions and for pre- and postoperative assessment of cartilage repair procedures. Although still widely used, conventional radiography bears significant limitations because it assesses cartilage indirectly by joint space width. Magnetic resonance imaging (MRI) enables direct visual

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Wetterling, Friedrich, Eva Chatzikonstantinou, Laurent Tritschler, et al. "Investigating potentially salvageable penumbra tissue in an in vivo model of transient ischemic stroke using sodium, diffusion, and perfusion magnetic resonance imaging." BMC Neuroscience 17, no. 1 (2016): 82. https://doi.org/10.1186/s12868-016-0316-1.

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<strong>Background: </strong> Diffusion magnetic resonance imaging (MRI) is the current-state-of-the-art technique to clinically investigate acute (0–24 h) ischemic stroke tissue. However, reduced apparent diffusion coefficient (ADC)—considered a marker of tissue damage—was observed to reverse spontaneously during the subacute stroke phase (24–72 h) which means that low ADC cannot be used to reflect the damaged tissue after 24 h in experimental and clinical studies. One reason for the change in ADC is that ADC values drop with cytotoxic edema (acute phase) and rise when vasogenic edema begins

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Baki, Abdulkader, Amani Remmo, Norbert Löwa, Frank Wiekhorst, and Regina Bleul. "Albumin-Coated Single-Core Iron Oxide Nanoparticles for Enhanced Molecular Magnetic Imaging (MRI/MPI)." International Journal of Molecular Sciences 22, no. 12 (2021): 6235. http://dx.doi.org/10.3390/ijms22126235.

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Colloidal stability of magnetic iron oxide nanoparticles (MNP) in physiological environments is crucial for their (bio)medical application. MNP are potential contrast agents for different imaging modalities such as magnetic resonance imaging (MRI) and magnetic particle imaging (MPI). Applied as a hybrid method (MRI/MPI), these are valuable tools for molecular imaging. Continuously synthesized and in-situ stabilized single-core MNP were further modified by albumin coating. Synthesizing and coating of MNP were carried out in aqueous media without using any organic solvent in a simple procedure.

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Nowak, Kristen L., Linda Fried, Anna Jovanovich, et al. "Dietary Sodium/Potassium Intake Does Not Affect Cognitive Function or Brain Imaging Indices." American Journal of Nephrology 47, no. 1 (2018): 57–65. http://dx.doi.org/10.1159/000486580.

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Background: Dietary sodium may influence cognitive function through its effects on cerebrovascular function and cerebral blood flow. Methods: The aim of this study was to evaluate the association of dietary sodium intake with cognitive decline in community-dwelling older adults. We also evaluated the associations of dietary potassium and sodium:potassium intake with cognitive decline, and associations of these nutrients with micro- and macro-structural brain magnetic resonance imaging (MRI) indices. In all, 1,194 participants in the Health Aging and Body Composition study with measurements of

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Heye, Anna K., Michael J. Thrippleton, Francesca M. Chappell, et al. "Blood pressure and sodium: Association with MRI markers in cerebral small vessel disease." Journal of Cerebral Blood Flow & Metabolism 36, no. 1 (2015): 264–74. http://dx.doi.org/10.1038/jcbfm.2015.64.

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Dietary salt intake and hypertension are associated with increased risk of cardiovascular disease including stroke. We aimed to explore the influence of these factors, together with plasma sodium concentration, in cerebral small vessel disease (SVD). In all, 264 patients with nondisabling cortical or lacunar stroke were recruited. Patients were questioned about their salt intake and plasma sodium concentration was measured; brain tissue volume and white-matter hyperintensity (WMH) load were measured using structural magnetic resonance imaging (MRI) while diffusion tensor MRI and dynamic contra

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Lavalle, Salvatore, Rosa Scapaticci, Edoardo Masiello, et al. "Beyond the Surface: Nutritional Interventions Integrated with Diagnostic Imaging Tools to Target and Preserve Cartilage Integrity: A Narrative Review." Biomedicines 13, no. 3 (2025): 570. https://doi.org/10.3390/biomedicines13030570.

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This narrative review provides an overview of the various diagnostic tools used to assess cartilage health, with a focus on early detection, nutrition intervention, and management of osteoarthritis. Early detection of cartilage damage is crucial for effective patient management. Traditional diagnostic tools like radiography and conventional magnetic resonance imaging (MRI) sequences are more suited to detecting late-stage structural changes. This paper highlights advanced imaging techniques, including sodium MRI, T2 mapping, T1ρ imaging, and delayed gadolinium-enhanced MRI of cartilage, which

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Pinter, Jule, Charles Chazot, Stefano Stuard, Ulrich Moissl, and Bernard Canaud. "Sodium, volume and pressure control in haemodialysis patients for improved cardiovascular outcomes." Nephrology Dialysis Transplantation 35, Supplement_2 (2020): ii23—ii30. http://dx.doi.org/10.1093/ndt/gfaa017.

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Abstract Chronic volume overload is pervasive in patients on chronic haemodialysis and substantially increases the risk of cardiovascular death. The rediscovery of the three-compartment model in sodium metabolism revolutionizes our understanding of sodium (patho-)physiology and is an effect modifier that still needs to be understood in the context of hypertension and end-stage kidney disease. Assessment of fluid overload in haemodialysis patients is central yet difficult to achieve, because traditional clinical signs of volume overload lack sensitivity and specificity. The highest all-cause mo

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COX, BRIAN. "CHEMISTRY: HOW DOES IT SHAPE UP?" COSMOS 04, no. 01 (2008): 55–69. http://dx.doi.org/10.1142/s0219607708000299.

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There is more to organic chemistry than the covalent bond. The design and synthesis of molecules, because of their particular architecture, are able to bind strongly target ions or molecules by utilizing lots of individually relatively weak non-covalent interactions has led to many novel and important applications. Examples include the transport of ions across biological membranes, the generation of unusual ionic species, such as sodium anions, the recovery of pure metals from mineral ores, and contrasting agents for magnetic resonance imaging (MRI).

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Zheng, Lin-Xin, Kai-En Guo, Jia-Qi Huang, et al. "Curcumin alleviated dextran sulfate sodium-induced colitis by recovering memory Th/Tfh subset balance." World Journal of Gastroenterology 29, no. 36 (2023): 5226–39. http://dx.doi.org/10.3748/wjg.v29.i36.5226.

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The liver is one of the organs most commonly involved in metastatic disease, especially due to its unique vascularization. It’s well known that liver metastases represent the most common hepatic malignant tumors. From a practical point of view, it’s of utmost importance to evaluate the presence of liver metastases when staging oncologic patients, to select the best treatment possible, and finally to predict the overall prognosis. In the past few years, imaging techniques have gained a central role in identifying liver metastases, thanks to ultrasonography, contrast-enhanced computed tomography

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Wolff, S. D., C. Eng, and R. S. Balaban. "NMR studies of renal phosphate metabolites in vivo: effects of hydration and dehydration." American Journal of Physiology-Renal Physiology 255, no. 4 (1988): F581—F589. http://dx.doi.org/10.1152/ajprenal.1988.255.4.f581.

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The present study characterizes the 31P-nuclear magnetic resonance (NMR) spectrum of rabbit kidneys in vivo and evaluates the effect of hydration on phosphorous metabolites including the organic solute glycerophosphorylcholine (GPC). Cortical phosphorylethanolamine is the predominant component of the phosphomonoester region of the 31P spectrum. The contribution of blood to the spectrum is mainly from 2,3 diphosphoglycerate, which comprises approximately 30% of the inorganic phosphate region. Acute infusion of 0.9% saline decreases the sodium content of the inner medulla by greater than 50% in

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Yamashita, Chikara, Hiroshi Shigeto, Norihisa Maeda, Takako Torii, Yasumasa Ohyagi, and Jun-ichi Kira. "A Case of Central Pontine Myelinolysis Caused by Hypophosphatemia Secondary to Refeeding Syndrome." Case Reports in Neurology 7, no. 3 (2015): 196–203. http://dx.doi.org/10.1159/000440711.

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Central pontine myelinolysis (CPM), which was originally considered to be the result of rapid correction of chronic hyponatremia, is not necessarily accompanied by hyponatremia or drastic changes in serum sodium level. Here, we report a case of an anorexic 55-year-old male with a history of pharyngo-laryngo-esophagogastrectomy, initially hospitalized with status epilepticus. Although his consciousness gradually recovered as we were controlling his convulsion, it deteriorated again with new onset of anisocoria, and magnetic resonance imaging (MRI) at this point revealed CPM. Rapid change of ser

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Horvat-Menih, Ines, Mary A. McLean, Maria Jesus Zamora-Morales, et al. "Multiarm, non-randomised, single-centre feasibility study—investigation of the differential biology between benign and malignant renal masses using advanced magnetic resonance imaging techniques (IBM-Renal): protocol." BMJ Open 14, no. 10 (2024): e083980. http://dx.doi.org/10.1136/bmjopen-2024-083980.

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IntroductionLocalised renal masses are an increasing burden on healthcare due to the rising number of cases. However, conventional imaging cannot reliably distinguish between benign and malignant renal masses, and renal mass biopsies are unable to characterise the entirety of the tumour due to sampling error, which may lead to delayed treatment or overtreatment. There is an unmet clinical need to develop novel imaging techniques to characterise renal masses more accurately. Renal tumours demonstrate characteristic metabolic reprogramming, and novel MRI methods have the potential to detect thes

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Tasdiqul, Islam, and Murmu Chiranjib. "Detectability of Spinal Metastasis in Known Malignancies: A Comparative Study between 1Tesla MRI and F18 Sodium Fluoride PET- CT." International Journal of Pharmaceutical and Clinical Research 15, no. 5 (2023): 452–61. https://doi.org/10.5281/zenodo.12563682.

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<strong>Background:</strong>  The development of spinal metastasis is a seminal event in the progression of common malignancies and their early detection plays a critical role in deciding the treatment protocol and assessing prognosis. There is no consensus in the literature regarding the preferred imaging modality. The study was undertaken with the objective to compare the efficacy of Magnetic Resonance Imaging (MRI) as against 18F Sodium Fluoride (Positron Emission Tomography- Computed Tomography) PET-CT in detection of spinal metastatic lesions. <strong>Methods:</strong> A to

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Śmierciak, Natalia, Wirginia Krzyściak, Marta Szwajca, et al. "Benefits and Meaning of Lipids Profile in Relation to Oxidative Balance and Brain Morphology in Schizophrenia." International Journal of Molecular Sciences 24, no. 14 (2023): 11375. http://dx.doi.org/10.3390/ijms241411375.

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Schizophrenia is characterized by complex metabolic dysregulations and their consequences. Until now, numerous theories have explained its pathogenesis, using a spectrum of available technologies. We focused our interest on lipid profile—periphery high-density cholesterol level and lipoproteins in the human brain and compared magnetic resonance imaging (MRI) scans of patients with schizophrenia and the healthy group. Detailed analysis of biochemical parameters was performed using magnetic resonance spectroscopy. Our study aimed to reveal correlations between periphery high-density lipoproteins

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Darwish, M. IM, R. K. Rowe, J. RC van der Maarel, L. Pel, H. Huinink, and P. LJ Zitha. "Contaminant containment using polymer gel barriers." Canadian Geotechnical Journal 41, no. 1 (2004): 106–17. http://dx.doi.org/10.1139/t03-072.

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Polymer gels are well known in the oil industry, but their potential for use as barriers to contaminant transport has not previously received significant study. As a first step, this paper examines the potential for a polyelectrolyte gel to serve as a barrier to the migration of sodium chloride. Two series of tests are reported. These involve the use of hydrogen pulsed field gradient nuclear magnetic resonance (HPFGNMR) to measure the self-diffusion on a microscopic scale and the use of magnetic resonance imaging (MRI) to monitor Na+ and H+ migration in the polymer gel with time. It is show

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Haberkorn, Uwe, and Annette Altmann. "Imaging Techniques for Gene Therapy: SPECT, PET, and MRI." Journal of Pharmacy Practice 14, no. 5 (2001): 383–96. http://dx.doi.org/10.1106/eqat-deqg-6hr6-11h3.

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Gene therapy by the transfer and expression of suicide genes is performed using genes coding for nonmammalian enzymes that transform nontoxic prodrugs into toxic metabolites. Employing radiolabeled specific substrates and scintigraphic procedures to determine the functional activity of the recombinant enzyme in vivo, a therapeutic window of maximal gene expression and consecutive drug administration may be defined. If the gene therapy approach is based on the transduction of receptor genes, the recombinant gene expression in tumor cells can be monitored with radiolabeled ligands. Transfer of t

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Schreiner, Markus M., Vladimir Mlynarik, Štefan Zbýň, et al. "New Technology in Imaging Cartilage of the Ankle." CARTILAGE 8, no. 1 (2016): 31–41. http://dx.doi.org/10.1177/1947603516632848.

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The incidence of osteochondral lesions, as well as osteoarthritis of the ankle joint following osteochondritis dissecans and trauma, has been reappraised in recent years. Consequently, an increasing number of surgical interventions using different cartilage repair techniques is performed in the ankle joint, which has resulted in a growing demand for repetitive and objective assessment of cartilage tissue and its repair. While morphological imaging does enable monitoring of macroscopic changes with increasing precision, it fails to provide information about the ultrastructural composition of ca

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Pruijm, Menno, Lucie Hofmann, Bruno Vogt, et al. "Renal Tissue Oxygenation in Essential Hypertension and Chronic Kidney Disease." International Journal of Hypertension 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/696598.

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Animal studies suggest that renal tissue hypoxia plays an important role in the development of renal damage in hypertension and renal diseases, yet human data were scarce due to the lack of noninvasive methods. Over the last decade, blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI), detecting deoxyhemoglobin in hypoxic renal tissue, has become a powerful tool to assess kidney oxygenation noninvasively in humans. This paper provides an overview of BOLD-MRI studies performed in patients suffering from essential hypertension or chronic kidney disease (CKD). In line with anim

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