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Journal articles on the topic 'Sodium caprylate'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

AMALARADJOU, MARY ANNE ROSHNI, THIRUNAVUKKARASU ANNAMALAI, PATRICK MAREK, et al. "Inactivation of Escherichia coli O157:H7 in Cattle Drinking Water by Sodium Caprylate." Journal of Food Protection 69, no. 9 (2006): 2248–52. http://dx.doi.org/10.4315/0362-028x-69.9.2248.

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Escherichia coli O157:H7 is an important foodborne pathogen. Cattle serve as one of the major reservoirs of E. coli O157:H7, excreting the pathogen in feces. Environmental persistence of E. coli O157:H7 is critical in its epidemiology on far MS, and the pathogen has been isolated from cattle water troughs. Thus, there is a need for an effective method for killing E. coli O157:H7 in cattle drinking water. In this study, the efficacy of sodium caprylate for killing E. coli O157:H7 in cattle drinking water was investigated. A four-strain mixture of E. coli O157:H7 was inoculated (6.0 log CFU/ml)

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Dhere, Manisha, Arti Majumdar, and Neelesh Malviya. "COMPLEX OF ELUXADOLINE WITH SODIUM CAPRYLATE FOR IMPROVED SOLUBILITY AND DISSOLUTION RATE." INDIAN DRUGS 57, no. 11 (2021): 22–26. http://dx.doi.org/10.53879/id.57.11.11857.

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In the present research, newly developed complex with sodium caprylate was investigated for solubility and dissolution enhancement of eluxadoline. Complexes were prepared in different ratios by solvent evaporation method and characterised solubility study, Infrared spectroscopy (IR), Diffrential scanning calorimetry (DSC), X-Ray Diffraction (XRD), drug content analysis and in vitro Drug release. The solubility and dissolution rate revealed most suitable ratio of eluxadoline and sodium caprylate (1:4). The IR, DSC and X-RD data also confirmed the results. It was concluded that complex prepared

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Tomilin, M. V., T. V. Korotkova, and P. A. Loginov. "Comparative analysis of quality attributes of a human albumin preparation with a modified stabilising composition." Biological Products. Prevention, Diagnosis, Treatment 23, no. 3-1 (2023): 411–21. http://dx.doi.org/10.30895/2221-996x-2023-23-3-1-411-421.

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Scientific relevance. The national and international human albumin preparations registered in the Russian Federation mainly differ in their excipient compositions. While all the international preparations of human albumin contain a mixture of sodium caprylate and N-acetyl-DL-tryptophan, the Russian ones contain only sodium caprylate. However, albumin stabilisation with sodium caprylate at high concentrations affects the ligand-binding properties of albumin. For this reason, as well as to achieve storage stability not only at temperatures of 2 °C to 8 °C but also at room temperature, most inter

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Ketan, Soni, and Sharma Kavita. "Eco-friendly Spectrophotometric analysis of Mefenamic acid (poorly water-soluble drug) using the mixed solvency concept." Indian Journal of Science and Technology 14, no. 28 (2021): 2337–41. https://doi.org/10.17485/IJST/v14i28.476.

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Abstract <strong>Objectives:</strong> To investigate an eco-friendly method to enhance the solubility of Mefenamic acid. The present investigation was to employ these hydrotropic solutions to extract the drugs from their dosage forms, precluding the use of costlier and harmful organic solvents. <strong>Methodology:</strong> Mefenamic acid was analyzed by using UV Visible spectrophotometer (Model 1800, Shimadzu), and its solubility (poorly water-soluble drug) measured by mixed solvency method. Sodium caprylate solution was used as a hydrotropic solubilizing agent.<strong> Fi

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Carpenter, Garima, and R. K. Maheshwari. "Formulation and development of fast dissolving oral film of a poorly soluble drug, frusemide with improved drug loading using mixed solvency concept and its evaluation." Journal of Drug Delivery and Therapeutics 8, no. 6 (2018): 132–41. http://dx.doi.org/10.22270/jddt.v8i6.2034.

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The aim of the present research work is to explore the application of mixed solvency concept to formulate and develop a fast dissolving oral film of furosemide with improved drug loading. In the present study, poorly soluble drug, furosemide was tried to be solubilized by employing the combination of physiologically compatible water-soluble additives (solubilizers) to formulate its fast dissolving formulations. For the development of fast dissolving oral film, firstly, different film forming polymers were tested for their film properties. The second fast dissolving layer was also formed and op

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6

Chede, Laxmi Shanthi, Brett A. Wagner, Garry R. Buettner, and Maureen D. Donovan. "Electron Spin Resonance Evaluation of Buccal Membrane Fluidity Alterations by Sodium Caprylate and L-Menthol." International Journal of Molecular Sciences 22, no. 19 (2021): 10708. http://dx.doi.org/10.3390/ijms221910708.

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The ability of sodium caprylate and l-menthol to fluidize phospholipid bilayers composed of lipids simulating the buccal epithelium was investigated using electron spin resonance (ESR) to evaluate the action of these agents as permeation enhancers. 5-Doxyl stearic acid (5-DSA) and 16-doxyl stearic acid (16-DSA) were used as spin labels to identify alterations in membrane fluidity near the polar head groups or inner acyl regions of the lipid bilayer, respectively. The molecular motion of both 5-DSA and 16-DSA showed increased disorder near the polar and inner hydrophobic regions of the bilayer

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7

Lee, Ying-Chi, and John H. Johnson. "Determination of sodium caprylate in plasma volume expanders by gas chromatography." Journal of Chromatography A 361 (January 1986): 279–84. http://dx.doi.org/10.1016/s0021-9673(01)86916-8.

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8

Ospennikov, Alexander S., Galina V. Kornilaeva, Viktor F. Larichev, et al. "Activity against SARS-CoV-2 of Various Anionic Disinfectants and Their Complexes with Hydrophobically Modified Chitosan." Eurasian Journal of Chemistry 110, no. 2 (2023): 51–58. http://dx.doi.org/10.31489/2959-0663/2-23-13.

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The aim of this work was to study virucidal activity against SARS-CoV-2 of several anionic disinfectants, which are antiseptics recommended by the U.S. Environmental Protection Agency (EPA), and to prepare their complexes with hydrophobically modified chitosan active against SARS-CoV-2. Experiments were per-formed using a clinical isolate of SARS-CoV-2 obtained from a patient in 2020. It was shown that sodium dodecyl benzene sulfonate (SDBS) is already active at rather small concentrations (above 2 mM), which completely deactivate the virus. In the same concentration range, sodium caprylate do

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9

Valipe, Satyender Rao, Jenifer Ann Nadeau, Thirunavukkarasu Annamali, Kumar Venkitanarayanan, and Thomas Hoagland. "In vitro antimicrobial properties of caprylic acid, monocaprylin, and sodium caprylate againstDermatophilus congolensis." American Journal of Veterinary Research 72, no. 3 (2011): 331–35. http://dx.doi.org/10.2460/ajvr.72.3.331.

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10

BANDO, Hiroshi. "Useful Oral Administration of Glucagon-Like Peptide 1 Receptor Agonist (GLP-1RA) as Semaglutide (Rybelsus) for Type 2 Diabetes Mellitus (T2DM)." Asploro Journal of Biomedical and Clinical Case Reports 5, no. 1 (2022): 38–41. http://dx.doi.org/10.36502/2022/asjbccr.6260.

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As recommended pharmacological agents for type 2 diabetes mellitus (T2DM), Glucagon-Like Peptide 1 receptor agonist (GLP-1Ra) is highly evaluated for its various beneficial effects. Among them, semaglutide (Rybelsus) has been in focus for useful oral formation with useful oral hypoglycemic agent (OHA). Administration per os is possible due to the developed technique of absorption enhancer sodium N-(8-[2-hydroxybenzoyl] amino) caprylate. Clinical efficacy was shown by a series of Peptide Innovation for Early Diabetes Treatment (PIONEER) with enough weight reduction and decreased HbA1c. From the

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BANDO, Hiroshi. "Latest Development of Administration Routes for Anti-Diabetic Agents using Insulin Nanoparticles (NPs)." Asploro Journal of Biomedical and Clinical Case Reports 5, no. 3 (2023): 165–68. http://dx.doi.org/10.36502/2022/asjbccr.6280.

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For the latest development for anti-diabetic agents, nanoparticles (NPs) have been in focus. Permeation enhancers (PEs) are known to increase the oral absorption of various kinds of macromolecules. One of PEs would be sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC), which has been used for glucagon-like peptide-1 receptor agonist (GLP-1RA) as oral semaglutide (Rybelsus). For insulin encapsulation, polyelectrolyte nanocomplex (PEC) have been the promising carriers. Furthermore, spray drying technique has been an adequate and well-known industrial method for developing pharmaceutical indu

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12

Agrawal, Rinshi, and RK Maheshwari. "Novel application of mixed solvency concept in the development of oral liquisolid system of a poorly soluble drug, cefixime and its evaluation." Journal of Drug Delivery and Therapeutics 8, no. 6-s (2018): 5–8. http://dx.doi.org/10.22270/jddt.v8i6-s.2167.

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Application of mixed solvency has been employed in the present research work to develop a liquisolid system (Powder formulation) of poorly water soluble drug, cefixime (as model drug). Material and Methods: For poorly water soluble drug cefixime, combination of solubilizers such as sodium acetate, sodium caprylate and propylene glycol as mixed solvent systems were used to decrease the overall concentration of solubilizers required to produce substantial increase in solubility and thereby resulting in enhanced drug loading capacity of cefixime. The procured sample of cefixime was characterized

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13

Khlybova, E. V., E. S. Kormshchikova, A. V. Drobkova, and I. V. Paramonov. "A Chromatographic Method for Assay of Sodium Caprylate in the Formulation “Albumin, Solution for Infusions”." Pharmaceutical Chemistry Journal 51, no. 3 (2017): 235–38. http://dx.doi.org/10.1007/s11094-017-1589-0.

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14

Kim, Jae Cheon, Eun Ji Park, and Dong Hee Na. "Gastrointestinal Permeation Enhancers for the Development of Oral Peptide Pharmaceuticals." Pharmaceuticals 15, no. 12 (2022): 1585. http://dx.doi.org/10.3390/ph15121585.

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Recently, two oral-administered peptide pharmaceuticals, semaglutide and octreotide, have been developed and are considered as a breakthrough in peptide and protein drug delivery system development. In 2019, the Food and Drug Administration (FDA) approved an oral dosage form of semaglutide developed by Novo Nordisk (Rybelsus®) for the treatment of type 2 diabetes. Subsequently, the octreotide capsule (Mycapssa®), developed through Chiasma’s Transient Permeation Enhancer (TPE) technology, also received FDA approval in 2020 for the treatment of acromegaly. These two oral peptide products have be

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15

Kollanoor, Anup, Pradeep Vasudevan, Manoj Kumar Mohan Nair, Thomas Hoagland, and Kumar Venkitanarayanan. "Inactivation of bacterial fish pathogens by medium-chain lipid molecules (caprylic acid, monocaprylin and sodium caprylate)." Aquaculture Research 38, no. 12 (2007): 1293–300. http://dx.doi.org/10.1111/j.1365-2109.2007.01799.x.

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16

Wang, Jianji, Zhenning Yan, Yang Zhao та Fengling Cui. "Partial Molar Volumes and Viscosities of Some α-Amino Acids in Micellar Solutions of Sodium Caprylate". Journal of Chemical & Engineering Data 49, № 5 (2004): 1354–58. http://dx.doi.org/10.1021/je049927v.

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17

Thakur, Yashi, and R. K. Maheshwari. "Novel Application of Mixed Solvency Concept to Develop and Formulate Dry Powder Injection for Reconstitution of a Poorly Water Soluble Drug, Amlodipine Besylate and their Evaluations." Journal of Drug Delivery and Therapeutics 11, no. 4-S (2021): 101–8. http://dx.doi.org/10.22270/jddt.v11i4-s.4991.

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In the recent generation of pharmaceutical research, it has been observed that many newly designed and discovered drug products have less water solubility. Thus, leading to difficulties in several developmental, manufacturing and administrative processes. Furthermore, the clinical trials of these drugs have witnessed a great failure due to their poor pharmacokinetics. The lineup of our research work was promotion of mixed solvency concept by formulating the dry powder injection for reconstitution of poorly water-soluble drug amlodipine besylate by decreasing the solubilisers concentration in s

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18

Sabin, Juan, Gerardo Prieto, Alfredo González-Pérez, Juan Ruso, and Felix Sarmiento. "Effects of fluorinated and hydrogenated surfactants on human serum albumin at different pHs." Biomacromolecules 74 (August 2, 2005): 176–82. https://doi.org/10.1021/bm050549w.

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Complexation between human serum albumin (HSA) and two different surfactants, one fully fluorinated (sodium perfluorooctanoate, SPFO) and one fully hydrogenated (sodium caprylate, SO), was studied using ú-potential measurements and difference spectroscopy. The study was carried out at three different pHs, 3.2, 6.7, and 10.0. The spectroscopy study was performed at pHs 6.7 and 10.0, given that at pH 3.2 high turbidity was observed in the wide range of surfactant concentrations. The results were interpreted in terms of the electrostatic and hydrophobic contributions to the stability

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19

JIANG, Cui-Lan, Li-Na WANG, Ji-Hong HAN, and Ye JIANG. "Detection of Sodium Caprylate in Human Serum Albumin by Precolumn Derivation Reversed Phase High Performance Liquid Chromatography." CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION) 38, no. 3 (2010): 425–28. http://dx.doi.org/10.3724/sp.j.1096.2010.00425.

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20

Wan, Yan, Ting Zhang, Tao Chen, Ying Wang, and Yifeng Li. "Sodium caprylate induced precipitation post Protein A chromatography as an effective means for host cell protein clearance." Protein Expression and Purification 164 (December 2019): 105460. http://dx.doi.org/10.1016/j.pep.2019.105460.

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21

Yan, Zhenning, Xiaolan Wang, Xiangru Bai, Shuangqiang Wang, and Jianji Wang. "Volumetric, conductometric and fluorescence probe studies of interactions between glycyl dipeptides and sodium caprylate in aqueous media." Journal of Chemical Thermodynamics 52 (September 2012): 89–94. http://dx.doi.org/10.1016/j.jct.2012.01.024.

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22

Kajii, Hiroshi, Toshiharu Horie, Masahiro Hayashi, and Shoji Awazu. "Fluorescence Study of the Membrane-Perturbing Action of Sodium Caprylate as Related to Promotion of Drug Absorption." Journal of Pharmaceutical Sciences 77, no. 5 (1988): 390–92. http://dx.doi.org/10.1002/jps.2600770506.

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23

Kajii, Hiroshi, Toshiharu Horie, Masahiro Hayashi, and Shoji Awazu. "Effects of sodium salicylate and caprylate as adjuvants of drug absorption on isolated rat small intestinal epithelial cells." International Journal of Pharmaceutics 33, no. 1-3 (1986): 253–55. http://dx.doi.org/10.1016/0378-5173(86)90061-x.

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24

Nadarzynski, Alexandra, Jonas Scholz, and Markus S. Schröder. "Skin Barrier Enhancing Alternative Preservation Strategy of O/W Emulsions by Water Activity Reduction with Natural Multifunctional Ingredients." Cosmetics 9, no. 3 (2022): 53. http://dx.doi.org/10.3390/cosmetics9030053.

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Water activity (aw) as an important parameter for self-preservation can help to control microbial growth in cosmetic formulations. However, high amounts of water-binding substances are required to lower the aw enough to affect microbial growth. Since consequences for the skin barrier have been poorly studied so far, we investigated the effect of aw-lowering agents on both the antimicrobial properties of o/w emulsions and skin physiological parameters. A combination of selected natural humectants (Sodium lactate, Propanediol, Erythritol, Betaine and Sodium PCA) with a total concentration of 28

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Li, Ying, and Chunyan Zhu. "Development and In Vitro and In Vivo Evaluation of Microspheres Containing Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate for the Oral Delivery of Berberine Hydrochloride." Molecules 25, no. 8 (2020): 1957. http://dx.doi.org/10.3390/molecules25081957.

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Microspheres containing absorption enhancer (sodium N-[8-(2-hydroxybenzoyl)amino]caprylate, SNAC) were developed to enhance the oral bioavailability of berberine hydrochloride (BER) with poor intestinal membrane permeability. Microspheres were prepared and characterized by particle size measurements, scanning electron microscopy, differential scanning calorimetry, BER payload and release, Caco-2 cell monolayer transport, and rat pharmacokinetics. The microspheres were spherical and had uniform size, high encapsulation efficiency and high loading capacity. In vitro release studies showed that B

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Rao, Nahid, Reenoo Jauhari, Vaishali Sati, and Pallavi Godiyal. "AN INSIGHT INTO THE TREATMENT STRATEGIES OF OBESITY USING SEMAGLUTIDE AND ITS COMPETITIVE ANALOGUES: A REVIEW ARTICLE." Journal of Applied Pharmaceutical Sciences and Research 5, no. 2 (2022): 3–16. http://dx.doi.org/10.31069/japsr.v5i2.02.

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Obesity is a major public health problem in the world. This growing rate represents an epidemic that requires immediate attention. Oral Semaglutide is a semaglutide compound with an absorption enhancer, a sodium N- (8 - [2-hydroxybenzoyl] amino) caprylate (SNAC). The mechanism of action simply produces Glucagon-like peptide-1 (GLP-1) as a food-based digestive hormone that acts as an appetite signal, stimulates insulin release, inhibits glucagon production, and regulates diarrhea. This article shows the correlation of GLP-1 association with motivation to feed and Semaglutide’s anorectic effect

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Chiang, Po-Chang, Gauri Deshmukh, Jia Liu, et al. "Evaluating the Pharmacokinetics and Systemic Effects of a Permeability Enhancer Sodium N-[8-(2-hydroxybenzoyl)amino] Caprylate in Rats." Journal of Pharmaceutical Sciences 109, no. 8 (2020): 2629–36. http://dx.doi.org/10.1016/j.xphs.2020.04.016.

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Ma, Hui, Chengzhi Yan, and Zhiping Mi. "Metabolomic Insights into Energy Utilization Strategies of Asiatic Toads (Bufo gargarizans) During Hibernation." Animals 15, no. 3 (2025): 403. https://doi.org/10.3390/ani15030403.

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Hibernation is a crucial adaptive strategy for amphibians, facilitating survival in harsh environmental conditions by lowering metabolic rates and reducing energy use. This study employed GC-MS and LC-MS metabolomics to systematically analyze the serum metabolome of Bufo gargarizans during hibernation, aiming to uncover its metabolic adaptation mechanisms. A total of 136 differentially expressed metabolites (DEMs) were identified, of which 115 were downregulated and 21 upregulated, mainly involved in amino acid, carbohydrate, and lipid metabolism. KEGG pathway analysis showed that most metabol

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Hu, Lixia, Jiaqin Tang, Xudong Zhang, and Yifeng Li. "Sodium caprylate wash during Protein A chromatography as an effective means for removing protease(s) responsible for target antibody fragmentation." Protein Expression and Purification 186 (October 2021): 105907. http://dx.doi.org/10.1016/j.pep.2021.105907.

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Gahlot, Neha, and Rajesh Kumar Maheshwari. "Formulation and development of vaginal films of poorly water soluble drug, metronidazole, using mixed solvency concept and their evaluations." Journal of Drug Delivery and Therapeutics 8, no. 6 (2018): 41–48. http://dx.doi.org/10.22270/jddt.v8i6.2085.

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Aim: To deliver antibacterial therapy in an efficacious way, film dosage form has been proposed for drug delivery in vagina which can overcome bioavailability issues of poorly water soluble drugs. The present research work is aimed to explore the application of mixed solvency concept to increase solubility of poorly water soluble drug, metronidazole. Materials and Methods: Metronidazole, a slightly soluble drug in water was tried to be solubilized by employing the combination of solubilizers like niacinamide, sodium benzoate, sodium caprylate, caffeine and urea to endeavour its fast dissolving

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31

Kim, Hwi Seung, and Chang Hee Jung. "Oral Semaglutide, the First Ingestible Glucagon-Like Peptide-1 Receptor Agonist: Could It Be a Magic Bullet for Type 2 Diabetes?" International Journal of Molecular Sciences 22, no. 18 (2021): 9936. http://dx.doi.org/10.3390/ijms22189936.

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The gastrointestinal tract secretes gut hormones in response to food consumption, and some of these stimulate insulin secretion. Glucagon-like peptide-1 (GLP-1) is an incretin peptide hormone released from the lower digestive tract that stimulates insulin secretion, suppresses glucagon secretion, and decreases hunger. GLP-1 receptor agonist (GLP-1RA) mimics the action of endogenous GLP-1, consequently reversing hyperglycemia and causing weight reduction, demonstrating its efficacy as an antidiabetic and antiobesity agent. Previously restricted to injection only, the invention of the absorption

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Widiyarti, Galuh, Megawati Megawati, and Muhammad Hanafi. "The Potential use of Geraniol Esters from Citronella Oil as Anticancer Agents." Oriental Journal of Chemistry 35, no. 3 (2019): 987–96. http://dx.doi.org/10.13005/ojc/350310.

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Geraniol which is mainly contained in citronella oil is one of the Indonesian natural products with anticancer potential. In this study, synthesis of geranyl butyrate, geranyl caproate, and geranyl caprylate from geraniol was conducted using sodium hydroxide as a catalyst. The aim was to enhance the anticancer activity of geraniol as a starting material. In order to achieve this, its esters were identified through the use of Gas Chromatography-Mass Spectroscopy (GCMS), Fourier Transform Infra Red (FTIR), Thin Layer Chromatography (TLC), and Proton Nuclear Magnetic Resonance (1H-NMR). They were

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McIntyre, C., J. Schmidt, M. C. Castelli, and B. Bittner. "Study on the impact of SNAC (sodium N-[8-(2-hydroxybenzoyl) amino] caprylate) on the bioavailability of ibandronate (IBN) in postmenopausal women." Journal of Drug Delivery Science and Technology 21, no. 6 (2011): 521–25. http://dx.doi.org/10.1016/s1773-2247(11)50084-x.

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Lucena, Antônio Edson de Souza, Divaldo de Almeida Sampaio, Ednaldo Rosas da Silva, Virgínia Florêncio de Paiva, Ana Cláudia Santiago, and Ana Cristina Lima Leite. "A new methodology for polyvalent intravenous immunoglobulin solution production with a two-stage process of viral inactivation." Brazilian Journal of Pharmaceutical Sciences 46, no. 4 (2010): 777–83. http://dx.doi.org/10.1590/s1984-82502010000400020.

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Highly purified intravenous immunoglobulin G concentrate (IV IgG) was produced with the use of polyethylene glycol associated to a single-stage precipitation by ethanol, instead of the classic Cohn-Oncley process, which employs cold alcohol as the precipitating agent, in a three-stage process. Precipitation of crude fraction containing more than 95% of immunoglobulin G was performed by liquid chromatography with a cation exchanger, CM-Sepharose, as a stationary phase. During the process, the product was subjected to two-stage viral inactivation. The first stage was performed by the action of s

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Fatoki, Toluwase Hezekiah, Omodele Ibraheem, Oladoja A. Awofisayo, Abiodun Samuel Oyedele, and Olapade Samuel Akinlolu. "In Silico Investigation of First-Pass Effect on Selected Small Molecule Excipients and Structural Dynamics of P-glycoprotein." Bioinformatics and Biology Insights 14 (January 2020): 117793222094318. http://dx.doi.org/10.1177/1177932220943183.

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In this study, the interaction of selected pharmaceutical excipients on the function of P-glycoprotein (P-gp) and activity of 6 cytochrome P450 (CYP) isoforms were computationally investigated. At binding free energy cut-off value of −5.0 kcal/mol, the result showed possible modulatory or inhibitory effect by cethyl alcohol on CPY3A4 and P-gp; cetyltrimethyl-ammonium bromide (CTAB) on CYP1A2 and P-gp; dibutyl sebacate on CYP2C9, CYP2E1, and P-gp; sodium caprylate on CYP1A2 and CYP3A4; while most of the tested excipients have good interaction with the cytochromes and P-gp. The predicted pharmac

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Shapira-Furman, Tovi, Ayala Bar-Hai, Amnon Hoffman, and Abraham J. Domb. "The Synthesis of SNAC Phenolate Salts and the Effect on Oral Bioavailability of Semaglutide." Molecules 29, no. 16 (2024): 3909. http://dx.doi.org/10.3390/molecules29163909.

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Purpose: Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC) is a well-known penetration enhancer widely used in commercial applications. This study aims to broaden its properties through a novel strategy of converting it into its phenolate salts. The objective is to investigate the synthesis of SNAC phenolate salts, specifically SNAC–choline (SNAC-CH), SNAC–sodium (SNAC-Na), and SNAC–phosphatidylcholine (SNAC-PC), and to explore their potential application in improving the oral absorption of semaglutide. Methods: The synthesis of SNAC phenolate salts was confirmed through 1H-NMR, FTIR, and a

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Mousa, Shaker A., Haifeng Zhang, Ahmad Aljada, et al. "Pharmacokinetics and Pharmacodynamics of Oral Heparin Solid Dosage Form in Healthy Human Subjects." Blood 110, no. 11 (2007): 4009. http://dx.doi.org/10.1182/blood.v110.11.4009.4009.

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Abstract Heparin is not orally absorbed, presumably because of its size and polyanionic charge and hence is administered parenterally, either by continuous or intermittent infusion or by subcutaneous (SC) injection. However, a formulation that would result in absorption of heparin after oral administration would provide an attractive alternative to parenteral heparin. In that regard several attempts to develop effective non-parenteral heparin formulations have been reported, but they have met with limited success. The present investigation determined the molecular structure, pharmacokinetic (P

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Money, Samuel R., and John W. York. "Development of Oral Heparin Therapy for Prophylaxis and Treatment of Deep Venous Thrombosis." Cardiovascular Surgery 9, no. 3 (2001): 211–18. http://dx.doi.org/10.1177/096721090100900302.

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Objective: To review the current research and published literature regarding the development of oral heparin therapy for the prophylaxis and treatment of deep venous thrombosis. Background: Currently, the accepted practice of prophylaxis and/or treatment of acute deep venous thrombosis (DVT) is intravenous or subcutaneous (SQ) heparin followed by oral warfarin or SC low molecular weight heparin (LMWH) therapy followed by warfarin. Both of which are less than ideal. More recently, advances have been made towards an effective oral heparin preparation that would resolve many of the drawbacks to t

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Nolasco-Soria, Héctor, Carlos Alfonso Alvarez-González, Dariel Tovar-Ramírez, Jorge González-Bacerio, Alberto del Monte-Martínez, and Fernando Vega-Villasante. "Optimization of Classical Lipase Activity Assays for Fish Digestive Tract Samples." Fishes 9, no. 7 (2024): 261. http://dx.doi.org/10.3390/fishes9070261.

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Fish possess lipases from embryonic development to adulthood. Lipase activity methods vary and significantly differ in terms of the concentration of the substrate used, bile salt, Ca2+, temperature, pH, and type of lipase units, which limits comparative studies. The three most-used substrates are p-nitrophenyl (p-NP), β-naphthyl (β-N) derivates, and emulsified natural oils. These were selected to be redesigned in this study to measure lipase activity under temperature, pH, ion, and bile salt conditions closer to fish physiology, using the appropriate molar absorption coefficient to calculate t

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Athavale, Maithili, Aldon Fernandes, John Kaundinya, and Gautam Daftary. "Validation of a simple, rapid and cost effective method for the estimation of caprylic acid and sodium caprylate from biological products using NEFA-C kit." Biologicals 38, no. 2 (2010): 321–24. http://dx.doi.org/10.1016/j.biologicals.2009.10.001.

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Li, Ying, Dandan Yang, and Chunyan Zhu. "Impact of Sodium N-[8-(2-Hydroxybenzoyl)amino]-caprylate on Intestinal Permeability for Notoginsenoside R1 and Salvianolic Acids in Caco-2 Cells Transport and Rat Pharmacokinetics." Molecules 23, no. 11 (2018): 2990. http://dx.doi.org/10.3390/molecules23112990.

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For drugs with high hydrophilicity and poor membrane permeability, absorption enhancers can promote membrane permeability and improve oral bioavailability. Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC) is a new kind of absorption enhancer that has good safety. To investigate the absorption enhancement effect of SNAC on non-polar charged and polar charged drugs and establish the absorption enhancement mechanism of SNAC, SNAC was synthesized and characterized. Two representative hydrophilic drugs—notoginsenoside R1 (R1) and salvianolic acids (SAs)—were selected as model drugs. In vitro Ca

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Hess, Shmuel, Victoria Rotshild, and Amnon Hoffman. "Investigation of the enhancing mechanism of sodium N-[8-(2-hydroxybenzoyl)amino]caprylate effect on the intestinal permeability of polar molecules utilizing a voltage clamp method." European Journal of Pharmaceutical Sciences 25, no. 2-3 (2005): 307–12. http://dx.doi.org/10.1016/j.ejps.2005.03.003.

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Granhall, Charlotte, Tine A. Bækdal, Astrid Breitschaft, Flemming L. Søndergaard, Thomas W. Anderson, and Mette Thomsen. "Absence of QTc Prolongation with Sodium N-(8-[2-Hydroxybenzoyl] Amino) Caprylate (SNAC), an Absorption Enhancer Co-Formulated with the GLP-1 Analogue Semaglutide for Oral Administration." Diabetes Therapy 12, no. 9 (2021): 2599–610. http://dx.doi.org/10.1007/s13300-021-01106-x.

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Castelli, M. Cristina, Diane F. Wong, Kristen Friedman, and M. Gary I. Riley. "Pharmacokinetics of Oral Cyanocobalamin Formulated With Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC): An Open-Label, Randomized, Single-Dose, Parallel-Group Study in Healthy Male Subjects." Clinical Therapeutics 33, no. 7 (2011): 934–45. http://dx.doi.org/10.1016/j.clinthera.2011.05.088.

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Kozak, Sarah M., Kyle M. Margison, and Dennis J. D'amico. "Synergistic Antimicrobial Combinations Inhibit and Inactivate Listeria monocytogenes in Neutral and Acidic Broth Systems." Journal of Food Protection 80, no. 8 (2017): 1266–72. http://dx.doi.org/10.4315/0362-028x.jfp-17-035.

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ABSTRACT The use of antimicrobial compounds can be an effective approach to control Listeria monocytogenes in ready-to-eat foods, but it can also be limited by cost, restrictions on concentrations in foods, and potential changes to organoleptic properties. Combinatorial approaches that produce additive or synergistic effects allow for reductions in individual antimicrobial concentrations while achieving the same level of control. The present study determined the MIC and MBC of an antimicrobial compound when used alone or in binary combinations against L. monocytogenes in growth media adjusted

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Weng, Huixian, Lefei Hu, Lei Hu, et al. "Corrigendum to “The complexation of insulin with sodium N‐[8‐(2‐hydroxybenzoyl)amino]‐caprylate for enhanced oral delivery: Effects of concentration, ratio, and pH” [Chinese Chemical Letters 33 (2022) 1889-1894]." Chinese Chemical Letters 36, no. 8 (2025): 111316. https://doi.org/10.1016/j.cclet.2025.111316.

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Kozak, Sarah M., Yustyna Bobak, and Dennis J. D'Amico. "Efficacy of Antimicrobials Applied Individually and in Combination for Controlling Listeria monocytogenes as Surface Contaminants on Queso Fresco." Journal of Food Protection 81, no. 1 (2017): 46–53. http://dx.doi.org/10.4315/0362-028x.jfp-17-279.

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ABSTRACT Outbreaks of listeriosis are continually attributed to the consumption of Hispanic-style soft cheeses contaminated with Listeria monocytogenes postpasteurization. Once contaminated, L. monocytogenes can grow rapidly in cheeses like Queso Fresco (QF) even when stored at refrigeration temperatures. Several antimicrobials, including acidified calcium sulfate with lactic acid (ACSL), ɛ-polylysine (EPL), hydrogen peroxide (HP), lauric arginate ethyl ester (LAE), and sodium caprylate (SC), have demonstrated antilisterial activity in food. The objectives of this study were to determine the e

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Шелехова, Т. М., И. М. Абрамова, Н. В. Шелехова, Л. И. Скворцова, Н. В. Полтавская, and М. В. Амелякина. "Comparative analysis of the chemical composition of grain distillates of russian and foreign production." Food processing industry, no. 10 (September 28, 2024): 110–14. http://dx.doi.org/10.52653/ppi.2024.10.10.022.

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к зерновым дистиллятам. Многообразие технологических схем и перерабатываемого сырья обуславливает значительные различия в химическом составе зерновых дистиллятов. Исследования, направленные на разработку новых инструментальных методов анализа и расширение нормируемых показателей для зерновых дистиллятов, позволят сформулировать дополнительные критерии качества. С использованием разработанных нами методик проведен сравнительный анализ химического состава дистиллятов из зерна пшеницы и кукурузы производства России, Шотландии, США. Определены диапазоны варьирования массовых концентраций для катио

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Ye, Dingwei, Xiaojie Bian, Weiqing Han, et al. "Phase II therapeutic equivalence study of Abiraterone Acetate Tablets (I) vs. ZYTIGA^® in patients with metastatic castration-resistant prostate cancer." Journal of Clinical Oncology 40, no. 16_suppl (2022): e17040-e17040. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e17040.

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e17040 Background: Abiraterone acetate is approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC). However, the originator abiraterone acetate (ZYTIGA) is observed to be with relatively low bioavailability and high pharmacokinetic variability. Abiraterone Acetate Tablets (I), in which Sodium N-[8-(2-hydroxy-benzoyl) amino] caprylate (SNAC) was added in the formulation as an absorption enhancer, was therefore developed by using nanocrystal technology to enhance the dissolution rate of pharmaceutical compounds, leading to the improvement of the low oral bioavailabil

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Ye, Dingwei, Xiaojie Bian, Weiqing Han, et al. "Phase II therapeutic equivalence study of Abiraterone Acetate Tablets (I) vs. ZYTIGA^® in patients with metastatic castration-resistant prostate cancer." Journal of Clinical Oncology 40, no. 16_suppl (2022): e17040-e17040. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e17040.

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e17040 Background: Abiraterone acetate is approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC). However, the originator abiraterone acetate (ZYTIGA) is observed to be with relatively low bioavailability and high pharmacokinetic variability. Abiraterone Acetate Tablets (I), in which Sodium N-[8-(2-hydroxy-benzoyl) amino] caprylate (SNAC) was added in the formulation as an absorption enhancer, was therefore developed by using nanocrystal technology to enhance the dissolution rate of pharmaceutical compounds, leading to the improvement of the low oral bioavailabil

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