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Journal articles on the topic 'Sodium citicoline'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Panda, Sagar Suman, Ravi Kumar B V V, Ganeswar Mohanta, and Jnyanaranjan Panda. "Reverse Phase Ultrafast Liquid Chromatography Method for Simultaneous Estimation of Citicoline Sodium and Piracetam in Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 6, no. 1 (2013): 1952–57. http://dx.doi.org/10.37285/ijpsn.2013.6.1.5.

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A simple, precise and accurate RP-UFLC method was developed for simultaneous determination of citicoline sodium and piracetam in tablets. Separation was carried on an Enable C18G column (250 mm × 4.6 mm i.d., 5 μm) using methanol: water (10 mM TEA) (75:25, v/v) as mobile phase at flow rate of 1 ml/min in isocratic mode. The PDA detection wavelength was 225 nm. The retention time of citicoline sodium and piracetam were 1.985 and 3.007 min, respectively. The method was validated for linearity, specificity, precision, accuracy and robustness as per ICH guidelines. The method was linear in the con

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2

Rayakwar, Neetesh, and Yuvraj Singh Dangi. "Development and characterization of controlled release bilayered tablets of Citicoline sodium." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 125–31. http://dx.doi.org/10.22270/jddt.v9i2-s.2471.

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Objectives: The aim of present investigation was formulation development and evaluation of bi-layer tablets of citicoline sodium. Materials and Methods: An aqueous granulation process was adopted to formulate citicoline sodium (CTS) bilayer tablets. Wet granulation method has been utilized for the formulation of bilayer CTS tablet. Citicoline sodium, microcrystalline cellulose (pH 101 & 102), HPMC K4, K15, K-100, PVP K-30, Magnesium stearate, cross-carmellose sodium, sodium starch glycolate and red oxide were used for preparation. Pre-formulation studies of citicoline sodium and drug excip

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3

ZHAO, Ming, Juan ZHANG, and Jin GAO. "Determination of sodium pyrosulfite in citicoline sodium injection." Pharmaceutical Care and Research 12, no. 6 (2012): 450–72. http://dx.doi.org/10.5428/pcar20120616.

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4

P.N., Aliyev. "INVESTIGATION OF THE IR-SPECTRUM OF SODIUM CITICOLINE IN CONDENSED MATTER PHYSICS." ИННОВАЦИОННЫЕ НАУЧНЫЕ ИССЛЕДОВАНИЯ 2023. 6-1(30) (June 18, 2023): 5–10. https://doi.org/10.5281/zenodo.8052756.

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The article investigates the mathematical model of the sodium citicoline molecule in condensed matter physics using the Gaussian software. A structural-dynamic model was constructed, based on which, according to the RHF/3-21G quantum model, calculations of the fundamental frequencies of vibrations of atoms and functional groups of the molecule were performed. Represented the data obtained in the form of a theoretically calculated IR spectrum of the compound. The obtained IR spectrum is also justified based on the quantum mechanical behavior of individual atoms and radicals of the molecule. Thi

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5

Panda, SagarSuman, Ganeswar Mohanta, and BeraVenkata Varaha Ravi Kumar. "Estimation of citicoline sodium in tablets by difference spectrophotometric method." Chronicles of Young Scientists 4, no. 1 (2013): 18. http://dx.doi.org/10.4103/2229-5186.108799.

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6

Kruchinina, Margarita V., Andrei A. Gromov, Elina V. Kruchinina, and Yulia A. Shishakina. "Changes in the electrical and viscoelastic parameters of erythrocytes in patients with manifestations of metabolic syndrome, COVID-19 convalescents, when exposed to citicoline in an in vitro experiment." Consilium Medicum 25, no. 11 (2024): 767–74. http://dx.doi.org/10.26442/20751753.2023.11.202528.

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Aim. To study changes in the electrical and viscoelastic parameters of erythrocytes using the method of dielectrophoresis in patients with manifestations of the metabolic syndrome who underwent COVID-19, when exposed to the drug citicoline in an in vitro experiment to reduce the severity of microcirculatory disorders. Materials and methods. 31 men were examined with manifestations of metabolic syndrome (50.6±9.9 years), COVID-19 convalescences, within 8 to 12 months after the disease, the diagnosis was confirmed by PCR, ELISA. The electrical and viscoelastic parameters of erythrocytes we

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7

Plotnikov, Mark B., Galina A. Chernysheva, Vera I. Smolyakova, et al. "Neuroprotective Effects of a Novel Inhibitor of c-Jun N-Terminal Kinase in the Rat Model of Transient Focal Cerebral Ischemia." Cells 9, no. 8 (2020): 1860. http://dx.doi.org/10.3390/cells9081860.

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A novel specific inhibitor of c-Jun N-terminal kinase, 11H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt (IQ-1S), has a high affinity to JNK3 compared to JNK1/JNK2. The aim of this work was to study the mechanisms of neuroprotective activity of IQ-1S in the models of reversible focal cerebral ischemia (FCI) in Wistar rats. The animals were administered with an intraperitoneal injection of IQ-1S (5 and 25 mg/kg) or citicoline (500 mg/kg). Administration of IQ-1S exerted a pronounced dose-dependent neuroprotective effect, not inferior to the effects of citicoline. Administration of IQ-1S at d

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8

Kalyn, Y., S. Gavrilova, T. Safarova, and E. Shipilova. "Comparative Efficacy and Safety of Antidepressive Mono- and Multimodal Therapy with Citicoline in Elderly Patients with Depression in Psychogeriatric Unit." European Psychiatry 33, S1 (2016): S470. http://dx.doi.org/10.1016/j.eurpsy.2016.01.1716.

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IntroductionCiticoline is a choline donor involved in the biosynthesis of brain phospholipids and acetylcholine, used for treating neurodegenerative disorders. Several studies have shown its beneficial effects both in degenerative and vascular cognitive decline. Due to its effects on the adrenergic and dopaminergic CNS activity, citicoline can also be used as an adjuvant in depression treatment.Objectives and aimsComparative evaluation of efficacy and safety of a multimodal antidepressive therapy with ceraxone (citicoline) plus one of the antidepressants (venlafaxine, agomelatine, or fluvoxami

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9

Patel, JimmiA, ChhaganbhaiN Patel, Bibhuranjan Panigrahi, and Badmanaban Ramalingan. "Stress degradation studies on citicoline sodium and development of a validated stability-indicating HPLC assay." Chronicles of Young Scientists 2, no. 3 (2011): 150. http://dx.doi.org/10.4103/2229-5186.90892.

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10

Gao, Jin, Ming Zhao, Xiaoying Fu, et al. "Identification of Related Substances in Citicoline Sodium Injection by HPLC-DAD and HPLC-MS/MS." Asian Journal of Chemistry 25, no. 14 (2013): 7697–704. http://dx.doi.org/10.14233/ajchem.2013.14572.

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11

S. Malgundkar, Mr Sanjay, and Dr Saira Mulla. "Validated Hptlc Method for Simulteneous Determination of Citicoline sodium and Piracetam in Combined Dosage Form." IOSR Journal of Pharmacy and Biological Sciences 9, no. 3 (2014): 28–33. http://dx.doi.org/10.9790/3008-09322833.

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12

Deepa, S., B. E. Kumara Swamy, and K. Vasantakumar Pai. "Electrochemical sensing performance of citicoline sodium modified carbon paste electrode for determination of dopamine and serotonin." Materials Science for Energy Technologies 3 (2020): 584–92. http://dx.doi.org/10.1016/j.mset.2020.06.001.

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13

Mok, Chee-Keng, Yan Ling Ng, Bintou Ahmadou Ahidjo, et al. "Evaluation of In Vitro and In Vivo Antiviral Activities of Vitamin D for SARS-CoV-2 and Variants." Pharmaceutics 15, no. 3 (2023): 925. http://dx.doi.org/10.3390/pharmaceutics15030925.

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The COVID-19 pandemic has brought about unprecedented medical and healthcare challenges worldwide. With the continual emergence and spread of new COVID-19 variants, four drug compound libraries were interrogated for their antiviral activities against SARS-CoV-2. Here, we show that the drug screen has resulted in 121 promising anti-SARS-CoV-2 compounds, of which seven were further shortlisted for hit validation: citicoline, pravastatin sodium, tenofovir alafenamide, imatinib mesylate, calcitriol, dexlansoprazole, and prochlorperazine dimaleate. In particular, the active form of vitamin D, calci

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14

Wang, Ning-qun, Li-ye Wang, Hai-ping Zhao, et al. "Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/369021.

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Luoyutong (LYT) capsule has been used to treat cerebrovascular diseases clinically in China and is now patented and approved by the State Food and Drug Administration. In this retrospective validation study we investigated the ability of LYT to protect against cerebral ischemia-reperfusion injury in rats. Cerebral ischemia-reperfusion injury was induced by middle cerebral artery occlusion followed by reperfusion. Capsule containing LYT (high dose and medium dose) as treatment group and Citicoline Sodium as positive control treatment group were administered daily to rats 30 min after reperfusio

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15

Liu, Yihan, Qicheng Zhang, Ninglin Zhou, et al. "Study on a novel poly (vinyl alcohol)/graphene oxide-citicoline sodium-lanthanum wound dressing: Biocompatibility, bioactivity, antimicrobial activity, and wound healing effect." Chemical Engineering Journal 395 (September 2020): 125059. http://dx.doi.org/10.1016/j.cej.2020.125059.

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16

Mahmoud, Omnia A., Maha A. Hegazy, Hesham Salem, and Azza A. Moustafa. "Comparative study of reversed-phase high-performance liquid chromatographyversusthin-layer chromatography—densitometry for determination of citicoline sodium in presence of its alkaline degradation products." Journal of Planar Chromatography – Modern TLC 28, no. 3 (2015): 241–47. http://dx.doi.org/10.1556/1006.2015.28.3.8.

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17

Danukalo, M. V., and Yu M. Kolesnyk. "The specificity of iNOS expression indicators in the basal magnocellular nucleus of rats under early pathogenetic correction in experimental neurodestruction." Zaporozhye Medical Journal 26, no. 5 (2024): 379–86. http://dx.doi.org/10.14739/2310-1210.2024.5.309732.

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Aim. To characterize iNOS expression indicators in the basal magnocellular nucleus of rats during early pathogenetic correction of neurodegeneration induced by intracerebroventricular colchicine administration. Materials and methods. The study was conducted using 50 male Wistar rats aged 10–11 months, which were divided into 5 experimental groups (n = 10). The control animals (group 1) were administered a 0.9 % NaCl solution intracerebroventricularly, while the other experimental group rats (groups 2–5) received a colchicine solution in the same manner. The following day, the animals from grou

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18

Plotnikov, Mark B., Galina A. Chernysheva, Oleg I. Aliev, et al. "Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats." Molecules 24, no. 9 (2019): 1722. http://dx.doi.org/10.3390/molecules24091722.

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c-Jun N-terminal kinase (JNK) is activated by various brain insults and is implicated in neuronal injury triggered by reperfusion-induced oxidative stress. Some JNK inhibitors demonstrated neuroprotective potential in various models, including cerebral ischemia/reperfusion injury. The objective of the present work was to study the neuroprotective activity of a new specific JNK inhibitor, IQ-1S (11H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt), in the model of global cerebral ischemia (GCI) in rats compared with citicoline (cytidine-5′-diphosphocholine), a drug approved for the treatment o

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19

AbouElhassan, Kariman M., Hatem A. Sarhan, Amal K. Hussein, Ashraf Taye, Yasmin M. Ahmed, and Mohamed A. Safwat. "Brain Targeting of Citicoline Sodium via Hyaluronic Acid-Decorated Novel Nano-Transbilosomes for Mitigation of Alzheimer’s Disease in a Rat Model: Formulation, Optimization, in vitro and in vivo Assessment." International Journal of Nanomedicine Volume 17 (December 2022): 6347–76. http://dx.doi.org/10.2147/ijn.s381353.

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20

"Synthesis of Process Related Impurities of Citicoline and Citicoline Sodium." Indian Journal of Chemistry 63, no. 3 (2024). http://dx.doi.org/10.56042/ijc.v63i3.6700.

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21

Medhat, Passant M., Heba-Alla H. Abd-ElSalam, Manal Mohamed Fouad, Amr M. Mahmoud, Hany Bebawi, and Nermine Samir Ghoniem. "Nanoparticles Modified Solid-Contact Potentiometric Sensor for Selective Nanomolar Citicoline Determination." Journal of The Electrochemical Society, March 26, 2025. https://doi.org/10.1149/1945-7111/adc5a9.

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Abstract In light of the increasing concerns surrounding the hyper-inflammatory condition of COVID-19 on the neurovascular system, it's crucial to explore treatments for both short- and long-term neurological issues. Citicoline sodium, known for its anti-inflammatory, antiviral, neuroprotective, and neurorestorative properties, plays a significant role in addressing neurological diseases, particularly cognitive defects following COVID-19. This work describes three glassy carbon potentiometric sensors fabricated to determine Citicoline sodium in its market dosage forms and spiked human plasma.

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22

Premi, Enrico, Valentina Cantoni, Alberto Benussi, et al. "Citicoline Treatment in Acute Ischemic Stroke: A Randomized, Single-Blind TMS Study." Frontiers in Neurology 13 (July 13, 2022). http://dx.doi.org/10.3389/fneur.2022.915362.

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BackgroundRecent research on animal models of ischemic stroke supports the idea that pharmacological treatment potentially enhancing intrinsic brain plasticity could modulate acute brain damage, with improved functional recovery. One of these new drugs is citicoline, which could provide neurovascular protection and repair effects.ObjectivesThe objective of this randomized, single-blind experimental study was to evaluate whether the treatment with Rischiaril® Forte was able to restore intracortical excitability measures, evaluated through transcranial magnetic stimulation (TMS) protocols, in pa

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23

Zhao, Penghui, Baoshu Liu, Chenxin Xie, Qiuju Li, Xue Du, and Hua Sun. "Crystallization of Citicoline sodium by Anti-solvent assisted with Ultrasound." Journal of Crystal Growth, June 2022, 126738. http://dx.doi.org/10.1016/j.jcrysgro.2022.126738.

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24

A.E. Mohamed, Ayman. "Synthesis, Isolation and Characterization of three acid and alkaline hydrolytic products of Nimodipine and Development of a valid RP-HPLC method for simultaneous determination of Nimodipine and Citicoline sodium in the presence of Nimodipine degradation products in Bulk and Tablets." Brazilian Journal of Analytical Chemistry 8 (January 19, 2021). http://dx.doi.org/10.30744/brjac.2179-3425.ar-52-2020.

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Impurity profiling of active pharmaceutical ingredients is a crucial step in assessing their quality. Moreover, the chemical nature of nimodipine makes it susceptible easily to acidic and alkaline hydrolysis. On the other hand, nimodipine is co-formulated with citicoline sodium pharmaceutically as tablets to treat cerebral ischemia. In this study, three degradation products of nimodipine were synthesized, isolated and characterized with aid of FTIR spectroscopy, 1H-NMR as well as LC-MS/MS after exposing to drastic acidic and alkaline conditions. Subsequently, a simple, selective and valid RP-H

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25

Bhattacharyya, Sayani, and Anisha Verma. "Preparation and characterization of multicomponent particles for controlled and tunable release of citicoline." Drug Delivery Letters 12 (June 20, 2022). http://dx.doi.org/10.2174/2210303112666220620093106.

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Background: Memory disorders require a steady-state balance of choline and cytidine. Citicoline is prescribed as an exogenous source of choline and cytidine. Objective: The present study proposes a mucoadhesive multiparticulate sustained delivery of citicoline as a supportive control for memory loss. Methods: The formulation of citicoline sodium microparticles was done by ionotropic gelation method using alginate and hydroxypropyl methylcellulose (HPMC) in three different ratios. The three formulations were preliminary evaluated for the in vitro drug release study. Depending on their release p

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26

Abbaszadeh, Mohammad, Rokhsana Rasooli, Mohsen Shadi Mazdaghani, Hamid Rajaian, and Hossein Ali Shamsaei. "Pharmacokinetics of citicoline after intravenous and intramuscular administration in dogs." Veterinary Science Development 8, no. 1 (2018). http://dx.doi.org/10.4081/vsd.2018.6945.

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Background: New studies have confirmed the role of citicoline in reversing different pathological conditions in canine medicine, but dosing regimens of this drug has not yet been investigated in dogs. Using a high-performance liquid chromatography (HPLC) system, this study aims to quantify the levels of citicoline in dogs plasma after intravenous (IV) and intramuscular (IM) administration.Design and methods: The subjects of this study were 12 male, mixed breed healthy dogs that were approximately 2 to 3 years old and had a body weight between 15 and 25 kg. Plasma samples were extracted followi

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27

Khodayar, Mohammad Javad, Maryam Shirani, Mehrad Nikravesh, Elaheh Mohammadi, Laya Sadat Khorsandi, and Saeedeh Shariati. "Protective Effect of Citicoline on Sodium Arsenite-Induced Nephrotoxicity in Mice." Jundishapur Journal of Natural Pharmaceutical Products In Press, In Press (2024). http://dx.doi.org/10.5812/jjnpp-144745.

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Background: Sodium arsenite (NaAsO2) is a common mineral contaminant in drinking water in numerous parts of the world. It has been shown to have cardiovascular, metabolic, neuroendocrine, and urinary effects on the body. There is abundant scientific evidence that establishes a strong correlation between arsenic exposure and kidney-related disorders. Objectives: The present study aimed to investigate the potential protective effect of citicoline against NaAsO2-induced nephrotoxicity. Methods: The groups included a control group, a group treated with NaAsO2 at a concentration of 50 ppm, a group

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28

Kou, Lin, Juan Tan, Wen Yang, Xiaoyue Liu, Jing Zhou, and Rong Liu. "Efficacy of Butylphthalide Injection in Conjunction with Citicoline Sodium in Treating Ischemic Stroke." Indian Journal of Pharmaceutical Sciences 86, S2 (2024). http://dx.doi.org/10.36468/pharmaceutical-sciences.spl.892.

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29

Chen, Keguang, Xiaoyan Liu, Chunmin Wei, Guiyan Yuan, and Rui Zhang. "Determination of Uridine in Human Plasma by HPLC and its Application in Citicoline Sodium Pharmacokinetics and Bioequivalence Studies." Journal of Bioequivalence & Bioavailability 03, no. 04 (2011). http://dx.doi.org/10.4172/jbb.1000062.

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30

Zhou, Zheng, Mingxuan Liu, Haoyu You, et al. "Multiple‐Stimuli‐Responsive Biomimetic Polypyrrole Delivery System for Synergistic Regulation and Restoration of Epileptic Foci." Advanced Functional Materials, June 23, 2025. https://doi.org/10.1002/adfm.202510305.

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AbstractConsidering that currently used anti‐epileptic drugs (AEDs) in clinical practice can only suppress abnormal discharges without intervening in the inflammatory microenvironment, combining anti‐inflammatory and antioxidant agents with AEDs is probably an effective approach to overcoming the limitations of AEDs. Additionally, damaged neurons and the blood‐brain barrier (BBB) in epileptic foci require corresponding repair to minimize the risks of triggering new epileptogenic events. Unfortunately, there are hardly any effective strategies that integrate inflammatory microenvironment regula

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31

Anjani Durga, Kodukula Mohana, and Asha Deepti Choppala. "ANALYTICAL TECHNIQUES IN NEUROPHARMACOLOGY: SIMULTANEOUS DETERMINATION OF CITICOLINE SODIUM AND PIRACETAM BY UV-SPECTROSCOPY AND HIGH PERFORMANCE LIQUID CHROMATOGRAPHY." Journal of Population Therapeutics and Clinical Pharmacology, July 10, 2024. http://dx.doi.org/10.53555/jptcp.v31i7.7171.

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32

Yuliani, Sapto, Muhammad Faishal Akbar, Nurfidho Rochmafihro, Yosi Uthary, and Lasmi Deslaila. "Effects of Centella asiatica L. On Spatial Memory and Bcl-2 Gene Expression in the Hippocampus of Rats Injected With Trimethyltin." Indonesian Journal of Pharmacy, June 25, 2021, 141–49. http://dx.doi.org/10.22146/ijp.1134.

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Cell death (apoptosis) in the hippocampus is related to impaired memory functions. Gotu kola (Centella asiatica) contains asiatic acid and asiaticoside, which act as antioxidants and improve memory function. This study was intended to determine the effects of gotu kola extracts on Bcl-2 gene expression and spatial memory in rats with impaired memory functions due to trimethyltin (TMT) injection. The rats were subdivided into six groups, each group consisting of 10. The normal group was given sodium carboxymethyl cellulose (CMC-Na); the TMT group was given CMC-Na; the positive group was given 2

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