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Dissertations / Theses on the topic 'Sodium humate'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Sohraby, Sarah. "Le canal sodium épithélial." Doctoral thesis, Universite Libre de Bruxelles, 1988. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/213399.

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2

Velho, Albertina Menezes. "Topology of human sodium dependent vitamin C transporters." Thesis, University of Kent, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405985.

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3

Robins, Gerard George. "Second messenger regulation of human epithelial sodium channels." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402198.

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4

Love, Thomas D. "The effect of exercise on sodium balance in humans." Thesis, Loughborough University, 2010. https://dspace.lboro.ac.uk/2134/7072.

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During exercise water and electrolytes are lost in sweat. There is a large variation in both sweat rate and sweat composition and as a consequence sweat electrolyte loss can be large, especially for sodium, the primary cation in sweat. The loss of large amounts of sodium in sweat has been linked with hyponatraemia and muscle cramps. Sodium intake is encouraged in some athletes and in some exercise situations, which is in direct contrast to guidelines aimed at the general population aimed at reducing average sodium intakes to 2.4g of sodium per day (6g salt/day). Dietary sodium intakes have bee

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5

Hills, Claire Elizabeth. "SGK and disrupted renal sodium handling in diabetes." Thesis, University of Warwick, 2006. http://wrap.warwick.ac.uk/81100/.

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Diabetic nephropathy is associated with secondary hypertension arising from aberrant sodium reabsorption in the kidney. This thesis characterises a novel human cell line derived from the human cortical collecting duct (HCD) to assess glucoseevoked changes in key elements, such as the serum and glucocorticoid inducible kinase (SGKI) and the epithelial sodium channel (ENaC), involved in the regulation of sodium transport. In addition I have also examined the effects of TGF-f3I and [Ci+]i on SGKI and ENaC expression. RT-PCR, western blot analysis, immunocytochemistry and single cell imaging were

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6

Winski, Shannon Lee 1967. "Metabolism and toxicity of sodium arsenate in human erythrocytes." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282320.

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Toxicity of arsenic species is dependent on chemical oxidation state. Inorganic arsenic in the trivalent state, arsenite or As(III), is more biologically active than pentavalent arsenic, arsenate or As(V), and is more toxic by most measures. As(V), however, is more stable and prevalent in the environment. One consequence of environmental exposure is peripheral vascular disease, which is primarily due to vascular changes, but toxicity to the erythrocyte has not been evaluated. To understand toxicity and the implications of arsenic oxidation state, human erythrocytes were utilized to model the u

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7

Charlton, J. A. "Aspects of sodium and magnesium interrelationships in mammalian absorption and metabolism." Thesis, University of Newcastle Upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376219.

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8

Cheung, Kwok-ho Alvin, and 張國豪. "The role of human sodium dicarboxylate cotransporter in oxidative stress." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B27769070.

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9

Ma, Jie. "Human Endogenous Sodium Pump Inhibitors Measurement, Source, Synthesis and Regulation." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2953.

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The sodium pump (SP or Na+,K+-ATPase) is a membrane embedded protein complex that pumps 3 sodium ions out and 2 potassium ions into the cell per cycle and in so doing creates a cell membrane electrochemical potential. The membrane potential is critical for any functional cell. In the vasculature, reduction in the voltage potential causes vascular smooth muscle contraction and a narrowing of blood vessels (vasoconstriction) which can lead to increased blood pressure (hypertension). Substantial research over the past several decades has provided a vast amount of research on SP inhibitors, someti

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10

Scoumanne, Ariane Claire Agnes Ghislaine. "Expression of the cardiac hH1 sodium channel in human vascular endothelium." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408244.

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11

Tan, Chong Da. "Metabolic regulation of epithelial sodium channels in human airway epithelial cells." Thesis, St George's, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546781.

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12

Whitaker, William Richard James. "The distribution of voltage-gated sodium channels in the human brain." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621736.

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13

Wang, Qian. "Regulation of sodium transport across epithelia derived from human mammary gland." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/17600.

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Doctor of Philosophy<br>Department of Anatomy and Physiology<br>Bruce D. Schultz<br>The first aim of this project is to define the cellular mechanisms that account for the low Na[superscript]+ concentration in human milk. MCF10A cells, which were derived from human mammary epithelium and grown on permeable supports, exhibit amiloride- and benzamil-sensitive short circuit current (I[subscript]sc), suggesting activity of the epithelial Na[superscript]+ channel, ENaC. When cultured in the presence of cholera toxin (Ctx), MCF10A cells exhibit greater amiloride sensitive I[subscript]sc at all time

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14

Xu, Hua. "Subcloning and regulation of a human intestinal sodium-phosphate cotransporter gene." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/284333.

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Phosphate plays a critical role in the body as a constituent of bone and tooth for body development, and as a urinary buffer for pH in body acid-base balance regulation. The phosphorus level in blood in human is between 3.0 to 4.5 mg/dl. When the blood phosphate concentration is lower than 2.5 mg/dl, the person develops hypophosphatemia. When the blood phosphate concentration is higher than 4.5 mg/dl, the person develops hyperphosphatemia. It is critically important for the body to control the phosphate level in blood and maintain the phosphate homeostasis. The kidney and the intestine are the

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15

Döring, Barbara. "Molekulare und funktionelle Charakterisierung des humanen Sodium-dependent Organic Anion Transporters (SOAT)." Giessen VVB Laufersweiler, 2010. http://geb.uni-giessen.de/geb/volltexte/2010/7636/index.html.

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16

Wright, Karen Faye. "Teaching Heart Failure Patients a Low-Sodium Diet." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/6155.

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Congestive heart failure (CHF) is a progressive medical condition affecting more than 7 million people in the United States (US) with 700,000 new cases reported annually. More than half of those treated for CHF are readmitted at least once a year. The problem addressed by this quality improvement initiative was lack of adherence to low sodium diet (LSD) among CHF patients, knowledge and skill deficit, and excessive 30-day CHF readmissions. The health belief model and the self-care deficit theory guide nurses in acquiring the skills needed to teach LSD. Twelve months of data were selected from

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17

Fotiadou, Parthena. "Effect of sodium butyrate on human placental trophoblast cells and cell lines." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322651.

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18

Ismail, Noor. "Hormone-induced expression of the epithelial sodium channel in human airway cells." Thesis, University of Dundee, 2013. https://discovery.dundee.ac.uk/en/studentTheses/b0adffc7-eac8-49c4-b0ed-35cea636a3a9.

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Respiratory distress syndrome and pulmonary oedema often result in poor health and in the worst case scenario, death. Several studies have proposed that the eventual resolution of these dangerous conditions is due to active sodium reabsorption through the epithelial sodium channel (ENaC), which is crucial for lung fluid clearance. Although clinical prognosis can be improved by using glucocorticoid hormones to augment the ENaC-dependent removal of liquid from the lungs, we still require a better understanding of the underlying mechanism in order to improve treatments in the future. This thesis,

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19

Morris, Susan Jane. "Pharmacological responses of the human skin microcirculation in health and in diabetes." Thesis, University of Exeter, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361348.

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20

Basquin, Cécile. "Etude de deux-cotransporteurs sodium-soluté : la mélibiose perméase d'Escherichia coli et le symporteur Na-Iode humain." Nice, 2005. http://www.theses.fr/2005NICE4006.

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L’étude des relations structure-fonction de deux protéines membranaires appartenant à la famille des transporteurs sodium/soluté constitue l’objet de ce travail de thèse. La mélibiose perméase d’Escherichia coli (MelB) est située dans la membrane interne des bactéries et catalyse l’accumulation des a-galactosides (mélibiose). Nous avons montré que la boucle cytoplasmique reliant les hélices-a IV et V constitue un domaine fonctionnel impliqué dans les mécanismes de translocation des substrats. Nous avons également précisé que cette boucle participerait à un changement de conformation intervenan

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21

Pasquié, Jean-Luc. "Hypertrophie cardiaque dans l'hypertension artérielle expérimentale et humaine : rôle du sodium alimentaire et de la bradykinine." Montpellier 1, 1997. http://www.theses.fr/1997MON1T027.

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22

Suades, Sala Albert. "Expression and characterization of a human sodium glucose transporter (hSGLT1) in Pichia pastoris." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/457436.

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En els últims 20 anys, la caracterització de proteines de membrana ha esdevingut un camp interessant per el disseny de fàrmacs però, la falta d’informació del seu mecanisme d’acció i estructura fa encara més difícil buscar noves dianes terapèutiques. Per tant, estudiar l’estructura i el mecanisme d’acció de proteines de membrana acceleraria la recerca de nous fàrmacs i les seves implicacions mèdiques. El projecte de tesis presentat aquí està centrat en explorar les característiques del transprotador de glucosa humà (hSGLT1). Aquest transportador està implicat en la absorció de glucosa intesti

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23

Selvarajah, Viknesh. "Novel mechanisms for buffering the haemodynamic effects of dietary salt and the relevance of skin sodium in humans." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/283604.

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Background: Hypertension is one of the most common diseases in the United Kingdom and it remains an important risk factor for cardiovascular morbidity and mortality. Dietary sodium is an important trigger for hypertension and humans show a heterogeneous blood pressure (BP) response to salt intake. The mechanisms for this have not been fully explained, with renal sodium handling thought to play a central role. Animal studies have shown that dietary salt loading results in Na+ accumulation and lymphangiogenesis in skin mediated by vascular endothelial growth factor-C (VEGF-C), both attenuating t

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24

Harris, Jesse. "Comparison of STERIPLEX™ HC and Sodium Hypochlorite Cytotoxicity on Primary Human Gingival Fibroblasts." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2662.

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This study examined the cytotoxic effects of STERIPLEX™ HC (sBioMed, Orem, UT) and sodium hypochlorite (NaOCl) on human fibroblast cells in vitro. Fibroblasts exposed to various concentrations of NaOCl or STERIPLEX™ HC were visualized via light microscopy. Dilutions of either NaOCl or STERIPLEX™ HC that did not appear to disrupt the integrity of the cells were recorded for further analysis. Cells were then cultured and grown to confluence in five separate plates. A void was created down the middle of each plate. If the cells were viable, cellular confluence was seen. If nonviable, conflue

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25

Rakova, Natalia [Verfasser]. "Long-term studies on sodium balance and their relevance to human health / Natalia Rakova." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1119803152/34.

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26

Huc, Sylvaine. "Caractérisation moléculaire et structurale de l'extrémité C-Terminale du co-transporteur sodium/iode humain (hNIS) : implication de ce domaine dans la régulation du transporteur." Montpellier 1, 2007. http://www.theses.fr/2007MON13516.

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Le NIS est une protéine membranaire intrinsèque, exprimée dans les cellules thyroïdiennes où il permet la captation et la concentration des ions iodures. Un premier volet des travaux de thèse a été consacré à l’expression en système bactérien et à la purification du domaine C-terminal de ce transporteur humain. La caractérisation biochimique et structurale (dichroïsme circulaire et RMN) a mis en évidence que cette extrémité C-terminale est peu structurée mais capable de dimériser. Ce fragment a également été utilisé comme sonde pour tester l’interaction avec des protéines à domaines PDZ. Un de

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27

Döring, Barbara [Verfasser]. "Molekulare und funktionelle Charakterisierung des humanen Sodium-dependent Organic-Anion-Transporters (SOAT) / vorgelegt von Barbara Döring." Giessen : VVB Laufersweiler, 2010. http://d-nb.info/1006825339/34.

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28

Antia, Irina J. "The turnover of sodium/potassium pumps in human lymphocytes during upregulation in response to lithium." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297074.

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29

Desaulniers, Philippe. "Étude des réponses phagocytaires et chimiotactiques du neutrophile humain dans des modèles in vitro." Thesis, Université Laval, 2006. http://www.theses.ulaval.ca/2006/23334/23334.pdf.

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Le neutrophile humain est impliqué dans la première ligne de défense du corps humain. Pour jouer ce rôle le neutrophile doit se rendre au site inflammatoire et phagocyter les agents microbiens. L’objectif de cette étude est d’étudier les mécanismes impliqués lors de la chimiotaxie des neutrophiles et la phagocytose. Les résultats obtenus permettent d’identifier plusieurs voies de signalisation impliquées dans ces deux réponses majeures du neutrophile et décrivent des différences majeures entre les signaux chimiotactiques qui permettent une spécialisation de la réponse.

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30

Proulx, Sophie. "Voies de signalisation du neutrophile humain dans le contexte de l'arthrite goutteuse." Thesis, Université Laval, 2010. http://www.theses.ulaval.ca/2010/27483/27483.pdf.

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31

Rosier, Stephen P. "Functional characterisation and regulation of recombinant human sodium-dependent vitamin C transporter isoforms in mammalian cells." Thesis, University of Kent, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413273.

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32

Sanglay, Gabriel Christopher. "Inactivation and Mechanism of Electron Beam Irradiation and Sodium Hypochlorite Sanitizers against a Human Norovirus Surrogate." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354305401.

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33

Lainé-Cessac, Pascale. "La pyridoxal kinase erythrocytaire humaine : son activation par les ions potassium, sodium, lithium ; son inhibition par les medicaments." Angers, 1996. http://www.theses.fr/1996ANGE0507.

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34

Pan, Huiyan. "Epidermal growth factor and functional voltage-gated sodium channel expression in human metastatic breast cancer in vitro." Thesis, Imperial College London, 2006. http://hdl.handle.net/10044/1/11229.

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35

Jenkins, Richard J. "The mechanisms whereby the sodium, potassium-ATPhase undergoes adaptive changes in human lymphocytes in response to lithium." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236273.

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36

Merron, Andrew James. "Molecular imaging of oncolytic adenoviruses in vivo using the human sodium/iodide symporter as a reporter gene." Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500075.

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37

Ozerlat, Iley. "Effects of estrogen on voltage-gated sodium channel expression and function in human breast cancer cell lines." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/11853.

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38

Aue, Aaron Douglass. "An Evaluation of the In Vivo Debridement Efficacy of 3.0% NaOCl vs. 6.0% NaOCl Ultrasound After Hand and Rotary Instrumentation in Human Mandibular Molars." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1253552721.

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39

Bekkers, J. M. "Studies of single ion channels : Nonstationary sodium current fluctuations in squid axon, and patch clamp analysis of acetylcholine-activated channels in cultured rat skeletal muscle." Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372643.

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40

Hirose, Sayako. "Propranolol Attenuates Late Sodium Current in a Long QT Syndrome Type 3-Human Induced Pluripotent Stem Cell Model." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265195.

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41

Ng, Chi Wing. "Detection of sodium and potassium in single human erythrocytes by laser-induced plasma spectroscopy : instrumentation and feasibility demonstration." HKBU Institutional Repository, 1999. http://repository.hkbu.edu.hk/etd_ra/173.

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42

Mokhtar, Noor Fatmawati. "Pharmacological studies of voltage-gated sodium channel expression in human breast cancer cells : control of metastatic cell behaviours." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/7119.

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The overall aim of this PhD was to improve our understanding, including the clinical potential, of neonatal Nav1.5 (nNav1.5) expression in human metastatic breast cancer. Mainly, the strongly metastatic MDA-MB-231 cells were used throughout the studies. The specific aims were threefold, as follows: 1) To test the effects of several types of voltage-gated sodium channel (VGSC) blocker on nNav1.5 mRNA and protein expression and metastatic cell behaviours (MCBs); (2) to determine the effects of hypoxia on the drug treatments and MCBs; and (3) to elucidate a possible association of carbonic anhydr

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43

Achard, Jean-Michel. "Régulation mécanique de l'activité du canal sodium sensible à l'amiloride du lymphocyte B humain : mise en évidence et étude des mécanismes cellulaires impliqués." Compiègne, 1996. http://www.theses.fr/1996COMPD990.

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44

Markadieu, Nicolas. "Etude du rôle de la phosphatidylinositol 3-kinase dans la réabsorption du sodium par un modèle de tubule distal et collecteur du rein." Doctoral thesis, Universite Libre de Bruxelles, 2005. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210988.

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Cette thèse vise à démontrer l’importance de la PI 3-kinase dans la régulation hormonale de la réabsorption rénale du sodium. Ce contrôle extrêmement précis, notamment par l’aldostérone, s’effectue au niveau du néphron distal. Nous avons utilisé comme modèle l’épithélium de cellules A6, dérivées du tubule distal de Xenopus Laevis. Le transport unidirectionnel de sodium s’effectue en deux étapes: depuis, l’entrée à partir du milieu luminal par des canaux sodiques épithéliaux (ENaCs) insérés dans la membrane apicale, jusqu’à la sortie vers le liquide extracellulaire par des pompes Na+/K+-ATPases

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45

Kuntz-Simon, Gaëlle. "Implication des variations de la concentration intracellulaire en thiols dans la reactivation du virus de l'immunodeficience humaine et du cytomegalovirus humain : effet du valproate de sodium sur la multiplication de ces virus." Université Louis Pasteur (Strasbourg) (1971-2008), 1995. http://www.theses.fr/1995STR13097.

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Comme decrit dans la litterature, nous confirmons que la n-acetyl-l-cysteine (nac), precurseur de glutathion (gsh), inhibe la transactivation de la sequence ltr ainsi que la multiplication du virus de l'immunodeficience humaine (vih) dans des cellules chroniquement infectees. Cependant, nous montrons que ces inhibitions sont independantes de l'augmentation du taux de gsh intracellulaire puisque d'autres precurseurs de gsh, tels l'oxothiazolidine 4-carboxylate ou l'homocysteine, ne produisent pas les memes effets, mais au contraire, stimulent la multiplication du vih. Par ailleurs, une augmenta

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46

Mies, Frédérique. "Régulation du canal sodium épithélial par les acides gras polyinsaturés n-3." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210514.

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I. DESCRIPTION DE PROJET DE RECHERCHE<p><p>Le canal sodium épithélial bloquable par l’amiloride (ENaC) est une protéine intégrale de la membrane apicale des épithéliums impliqués dans l’absorption du sodium. Deux fonctions majeures sont directement liées au fonctionnement d’ENaC. D’une part, la régulation de la balance sodée par le rein et donc de la pression artérielle et d’autre part, la clairance du fluide alvéolaire pulmonaire.<p>Le transport vectoriel de sel et d’eau à travers ces épithéliums à jonctions serrées repose sur un transport actif de sodium entraînant un flux osmotique d’eau. C

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47

DAMIANI, RENATA. "Influência do butirato de sódio, da cicloheximida e do cloreto de manganês na produtividade, glicosilação e propriedades biológicas da tireotrofina humana derivada de CHO." reponame:Repositório Institucional do IPEN, 2013. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10602.

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Made available in DSpace on 2014-10-09T12:42:23Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:02:00Z (GMT). No. of bitstreams: 0<br>Tese (Doutoramento)<br>IPEN/T<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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48

Kondo, Yasushi. "Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells." Kyoto University, 2018. http://hdl.handle.net/2433/230976.

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49

Mizehoun, Adissoda Gbedecon Carmelle. "Apport alimentaire de sodium, potassium et iode, relation avec l'état nutritionnel au Bénin." Thesis, Limoges, 2015. http://www.theses.fr/2015LIMO0134/document.

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Une consommation élevée de sodium et une faible consommation de potassium sont associées à la survenue de l'HTA et des MCV. Limiter la consommation de sel et encourager celle de « plus de fruits et légumes » sont des mesures efficaces pour réduire l’incidence de ces maladies. Ces interventions nécessitent des données épidémiologiques fiables. Elles doivent aussi tenir compte de la disponibilité adéquate de l’iode dans le sel pour assurer un statut optimal en iode aux populations. Il n’existe pas de données représentatives sur le niveau de consommation en sodium, potassium et iode en population

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50

Siefers, Kyle John. "Sodium salicylate prevents inflammation-associated decreases in phosphorylated-Enos SER1177 in human aortic endothelial cells through an AMPK-dependent mechanism." Thesis, University of Iowa, 2014. https://ir.uiowa.edu/etd/4753.

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Obesity is associated with chronic inflammation and increased risk of developing cardiovascular disease (CVD). Obesity is also associated with nitric oxide (NO)-mediated vascular endothelial dysfunction (VED), an independent predictor of increased CVD risk in humans. Pro-inflammatory cytokines secreted by the adipose tissue, such as TNF-Α, may contribute to VED through promotion of insulin resistance or directly through a reduction in endothelial NO synthase (eNOS) expression and/or phosphorylation. Sodium salicylate (Na-Sal) is a non-acetylated aspirin that inhibits the pro-inflammatory trans

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