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Journal articles on the topic 'Sodium new houttuyfonate (SNH)'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Yan, Guiming, Yuanqing Si, Jing Shao, Tianming Wang, Changzhong Wang, and Daqiang Wu. "Sodium Houttuyfonate and Sodium New Houttuyfonate Affect the Composition of Gut Microbiota and Production of Inflammatory Factors in Mice." Natural Product Communications 15, no. 11 (2020): 1934578X2097251. http://dx.doi.org/10.1177/1934578x20972518.

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Houttuynia drugs, including sodium houttuyfonate (SH) and sodium new houttuyfonate (SNH), are derivatives of the active ingredient of Houttuynia cordata, which can be used as both a vegetable and medicine in China. We aimed to explore the regulation effects of SH and SNH on the gut microbiota and production of inflammatory factors in mice. Here, we found that SH and SNH led to an increase in the production of interferon gamma and nuclear factor κ, and decreased the production of lipocalin-2 in the mice. The alpha diversity results of gut microbiota of the mice showed that the gut microbiota of

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2

Jiang, Rilei, Cheng Hu, Qian Li, et al. "Sodium new houttuyfonate suppresses metastasis in NSCLC cells through the Linc00668/miR-147a/slug axis." Journal of Experimental & Clinical Cancer Research 38, no. 1 (2019): 155. https://doi.org/10.1186/s13046-019-1152-9.

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<strong>Background: </strong>As most lung cancer patients present with invasive, metastatic disease, it is vital to investigate anti-metastatic treatments for non-small cell lung cancer (NSCLC). <i>Houttuynia cordata</i> is commonly used as a Chinese anticancer medicine in the clinic, and sodium new houttuyfonate (SNH), a main compound of this herb, has long been found to have antibiotic effects, although its anticancer effects have not been investigated. Here, we tried to address this lack of research from the perspective of the competing endogenous RNA (ceRNA) theory.<strong>Methods: </stron

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3

He, Lixin, Huili Feng, Baoyi Yin та ін. "Sodium New Houttuyfonate Induces Apoptosis of Breast Cancer Cells via ROS/PDK1/AKT/GSK3β Axis". Cancers 15, № 5 (2023): 1614. http://dx.doi.org/10.3390/cancers15051614.

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Background: Sodium new houttuyfonate (SNH) has been reported to have anti-inflammatory, anti-fungal, and anti-cancer effects. However, few studies have investigated the effect of SNH on breast cancer. The aim of this study was to investigate whether SNH has therapeutic potential for targeting breast cancer. Methods: Immunohistochemistry and Western blot analysis were used to examine the expression of proteins, flow cytometry was used to detect cell apoptosis and ROS levels, and transmission electron microscopy was used to observe mitochondria. Results: Differentially expressed genes (DEGs) bet

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4

Jia, Fengjing, Qun Yu, Ling Zhao, Yunhui Shen, Haidong Guo, and Feng He. "Sodium New Houttuyfonate Inhibits Cancer-Promoting Fusobacterium nucleatum (Fn) to Reduce Colorectal Cancer Progression." Cancers 14, no. 24 (2022): 6111. http://dx.doi.org/10.3390/cancers14246111.

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Colorectal cancer (CRC) is a major cause of morbidity and mortality worldwide. Recent studies showed that the common anaerobe Fusobacterium nucleatum (Fn) is closely associated with a higher risk for carcinogenesis, metastasis, and chemoresistance of CRC. However, there is no specific antimicrobial therapy for CRC treatment. Herbal medicine has a long history of treating diseases with remarkable effects and is attracting extensive attention. In this study, we tested six common phytochemicals for their antimicrobial activities against Fn and whether anti-Fn phytochemicals can modulate CRC devel

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5

Yang, Linsong, Jia Xu, Yucheng Li, et al. "Influence of Sodium New Houttuyfonate as a New EGFR-TK Inhibitor on the Apoptosis and Autophagy of MCF-7 Cells and Its Toxicity to Caenorhabditis elegans." Processes 11, no. 6 (2023): 1652. http://dx.doi.org/10.3390/pr11061652.

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Sodium new houttuyfonate (SNH) is volatile oil extracted from Houttuynia cordata Thunb. Its molecular formula is C14H27O5SNa, and molecular weight is 330.41. It is a new anti-inflammatory drug that has been used clinically over recent years. In this work, the binding interaction simulation study on SNH and epidermal growth factor receptor-tyrosine kinase (EGFR-TK) was conducted. SNH demonstrated a good binding ability to EGFR-TK and formed hydrogen-bonds with Cys773, Asp776, and Tyr777. This indicated that SNH might play an antitumor role as a potential inhibitor of EGFR-TK. In vitro, after tr

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6

Yang, Xiaofeng, Liping Wang, Minglei Zhao, Haiping Qi, and Yao Wu. "A 4-Methylumbelliferone-based Fluorescent Probe for Sodium New Houttuyfonate." Chinese Journal of Chemistry 28, no. 8 (2010): 1469–74. http://dx.doi.org/10.1002/cjoc.201090251.

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7

Zhou, Yefei, Meixian Zhou, Dunlin Zhang, Honglin Zhang, and Liyang Zhang. "Immune response of AA broilers to IBV H120 vaccine and sodium new houttuyfonate." Research in Veterinary Science 89, no. 3 (2010): 373–77. http://dx.doi.org/10.1016/j.rvsc.2010.04.010.

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8

Shui, Yusen, Qingsong Jiang, Xiaoying Lyu, et al. "Inhibitory effects of sodium new houttuyfonate on growth and biofilm formation of Streptococcus mutans." Microbial Pathogenesis 157 (August 2021): 104957. http://dx.doi.org/10.1016/j.micpath.2021.104957.

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9

Yang, Xiao-Yan, Tianyuan Shi, Gaofei Du, et al. "iTRAQ-Based Proteomics Revealed the Bactericidal Mechanism of Sodium New Houttuyfonate against Streptococcus pneumoniae." Journal of Agricultural and Food Chemistry 64, no. 32 (2016): 6375–82. http://dx.doi.org/10.1021/acs.jafc.6b02147.

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10

Yang, Xiao-Yan, Gui-Bin Wang, Yao-Jin Le, Wan-Ting Liu, and Qing-Yu He. "Quantitative Proteomics Reveals the Antitumor Effects of Sodium New Houttuyfonate on Non-small Cell Lung Cancer." Journal of Exploratory Research in Pharmacology 000, no. 000 (2021): 000. http://dx.doi.org/10.14218/jerp.2021.00007.

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11

Yang, Xiao-Feng, Hanchun Yao, Ji-Bao Zhai, and Hua Li. "Chemiluminescence Determination of Sodium New Houttuyfonate in Pharmaceutical Preparations Based on Tween 80—Rhodamine B System." Journal of Fluorescence 17, no. 1 (2006): 15–21. http://dx.doi.org/10.1007/s10895-006-0150-4.

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12

Dai, Kejun, Ling Chen, Jun Liu, Yuqiong Ding, Cheng Gu, and Xujing Lu. "MiR-147a mediated by sodium new houttuyfonate could enhance radiosensitivity of non-small cell lung cancer cells via suppressing STAT3." Advances in Clinical and Experimental Medicine 30, no. 2 (2021): 173–81. http://dx.doi.org/10.17219/acem/130599.

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13

Lu, Xi, Xinyi Yang, Xue Li, et al. "In Vitro Activity of Sodium New Houttuyfonate Alone and in Combination with Oxacillin or Netilmicin against Methicillin-Resistant Staphylococcus aureus." PLoS ONE 8, no. 7 (2013): e68053. http://dx.doi.org/10.1371/journal.pone.0068053.

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14

Yang, Guangyuan, Ruotong Yang, Xiaoxiao Zhu, et al. "In vitro and in vivo activity of sodium houttuyfonate and sodium new houttuyfonate against Candida auris infection by affecting adhesion, aggregation, and biofilm formation abilities." Microbiology Spectrum, June 18, 2025. https://doi.org/10.1128/spectrum.00222-25.

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ABSTRACT Candida auris is a rapidly spreading multidrug-resistant fungus that causes fatal infections under certain global conditions. Sodium houttuyfonate (SH) and sodium new houttuyfonate (SNH) are stable derivatives of houttuynin (decyl aldehyde) extracted from Houttuynia cordata , both possessing antifungal and antibacterial pharmacological activities. However, the inhibitory effects of SH and SNH on C. auris remain unclear. Therefore, this study aims to evaluate the potential activity and possible mechanisms of SH and SNH as antifungal agents against C. auris . First, our results showed t

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15

Wu, Daqiang, Xiaomei He, Mengxue Hu та ін. "Sodium New Houttuyfonate Effectively Improves Phagocytosis And Inhibits the Excessive Release of Inflammatory Factors By Repressing TLR4/NF-Кb Pathway in Macrophages". Current Pharmaceutical Biotechnology 24 (18 квітня 2023). http://dx.doi.org/10.2174/1389201024666230418163100.

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aims: We aim to investigate the effect and possible mechanism of SNH on macrophages against bacteria in vitro. background: Sodium new houttuyfonate (SNH) is an adduct of houttuyfonate, the main component of the common Chinese medicine plant Houttuynia cordata, which has been widely applied in antibacterial and anti-inflammatory in the clinic. Due to the mild direct antimicrobial activity in vitro, the antimicrobial mechanism of SNH is still unclear. objective: The effect and possible mechanism of SNH on macrophages against bacteria were investigated to shed light on the antibacterial mechanism

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16

Zhang, Qian, Fangyan Liu, Meng Zeng, et al. "Antifungal Activity of Sodium New Houttuyfonate Against Aspergillus fumigatus in vitro and in vivo." Frontiers in Microbiology 13 (April 26, 2022). http://dx.doi.org/10.3389/fmicb.2022.856272.

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Aspergillus fumigatus is an important pathogen causing invasive aspergillosis, which is associated with high morbidity and mortality in immunocompromised people. However, the treatment of A. fumigatus infection is a growing challenge, owing to the limited availability antifungal agents and the continual emergence of drug-resistant strains. Drug repurposing is a potential strategy to solve this current problem. Sodium new houttuyfonate (SNH), derived from houttuynin, extracted from Houttuynia cordata, has anti-bacterial and anti-Candida albicans effects. However, whether it has anti-A. fumigatu

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17

Bao, Yilin, Dingxian Feng, Jinping Zhang, et al. "Efficacy of sodium new houttuyfonate against Aspergillus flavus: insights from in vitro and in vivo models of invasive pulmonary aspergillosis." Frontiers in Pharmacology 16 (May 1, 2025). https://doi.org/10.3389/fphar.2025.1577561.

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Aspergillus flavus is an opportunistic pathogenic fungus that causes invasive aspergillosis in humans. Due to the limited variety and quantity of clinical antifungal drugs and their adverse effects, the development of new broad-spectrum antifungal drugs is urgently required. Our preliminary research showed that sodium new houttuyfonate (SNH) was efficacious against A. fumigatus infection, but its effects against A. flavus remain unknown. In this study, we used the microdilution broth susceptibility method to determine the antifungal activities of four antifungal drugs and SNH against 12 clinic

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18

Zhou, Xue, Fujiao Huang, Jinping Zhang, et al. "The immunomodulatory effects of sodium new houttuyfonate on different states of macrophage against Aspergillus fumigatus infection via distinct mechanism in invasive pulmonary aspergillosis." Chinese Medicine 20, no. 1 (2025). https://doi.org/10.1186/s13020-025-01157-3.

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Abstract Background Invasive pulmonary aspergillosis (IPA) is usually caused by Aspergillus fumigatus infection and associated with high morbidity and mortality in immunocompromised patients. Sodium new houttuyfonate (SNH) has antifungal and immunomodulatory properties, but the therapeutic effect against IPA remains unknown. Methods The therapeutic effect of SNH in mice with IPA was determined by histopathological analysis and measurements of fungal loads. The toxicity of SNH to mouse alveolar macrophages (MH-S cells) and the changes in phagocytosis ability of MH-S cells to A. fumigatus were d

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19

Li, Xue, Penghe Wang, Xinxin Hu, et al. "The combined antibacterial effects of sodium new houttuyfonate and berberine chloride against growing and persistent methicillin-resistant and vancomycin-intermediate Staphylococcus aureus." BMC Microbiology 20, no. 1 (2020). http://dx.doi.org/10.1186/s12866-020-02003-2.

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Abstract Background Infections caused by drug-resistant Staphylococcus aureus, especially vancomycin-intermediate Staphylococcus aureus (VISA), leave clinicians with limited therapeutic options for treatment. Persister cells is a leading cause of recalcitrant infection and antibiotic treatment failure, and there is no drug in clinical use that specifically targets persister cells currently. Here, we report a promising combination therapy of sodium new houttuyfonate (SNH) and berberine chloride (BBR) which is able to eradicate both growing and persistent drug-resistant Staphylococcus aureus. Re

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20

"Effects of sodium new houttuyfonate on proliferation, apoptosis and migration of A2780 cells." International Journal of Frontiers in Medicine 4, no. 2 (2022). http://dx.doi.org/10.25236/ijfm.2022.040209.

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21

Zhao, Yeye, Longfei Mei, Yuanqing Si, et al. "Sodium New Houttuyfonate Affects Transcriptome and Virulence Factors of Pseudomonas aeruginosa Controlled by Quorum Sensing." Frontiers in Pharmacology 11 (October 2, 2020). http://dx.doi.org/10.3389/fphar.2020.572375.

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22

Jiang, Rilei, Cheng Hu, Qian Li, et al. "Sodium new houttuyfonate suppresses metastasis in NSCLC cells through the Linc00668/miR-147a/slug axis." Journal of Experimental & Clinical Cancer Research 38, no. 1 (2019). http://dx.doi.org/10.1186/s13046-019-1152-9.

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23

Jiang, Rilei, Bing Lu, Fanchao Feng, et al. "The sodium new houttuyfonate suppresses NSCLC via activating pyroptosis through TCONS ‐14036/ miR ‐1228‐5p/ PRKCDBP pathway." Cell Proliferation, January 25, 2023. http://dx.doi.org/10.1111/cpr.13402.

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24

Wu, Jiadi, Daqiang Wu, Yeye Zhao, et al. "Sodium New Houttuyfonate Inhibits Candida albicans Biofilm Formation by Inhibiting the Ras1-cAMP-Efg1 Pathway Revealed by RNA-seq." Frontiers in Microbiology 11 (August 25, 2020). http://dx.doi.org/10.3389/fmicb.2020.02075.

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