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Dissertations / Theses on the topic 'Solid dosage form'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Massinga, Pedro Horacio. "Gel-based solid dosage form for pesticide delivery." Diss., University of Pretoria, 2008. http://hdl.handle.net/2263/23498.

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The aim of this research was to develop a solid dosage form containing 1.5 g of the pesticide cypermethrin. The dosage should be stable in a tropical climate. In addition, it is to disintegrate and disperse in 10 L of tap water within 3 minutes. Such dissolution should yield a 150 ppm dispersion of cypermethrin, stable for at least one week. This provides for a dip dispersion to treat ticks and fly infestation on livestock. A new solid dosage was formulated as the scope of this research. It is a gel-based solid dosage form. Polymer electrolyte ASP4 - a copolymer of methacrylic acid, ethyl acry

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2

Nqabeni, Luxolo. "Development of an antiretroviral solid dosage form using multivariate analysis." Thesis, Nelson Mandela Metropolitan University, 2007. http://hdl.handle.net/10948/705.

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The aim of pharmaceutical development is to design a quality product and the manufacturing process to deliver the product in a reproducible manner. The development of a new and generic formulation is based on a large number of experiments. Statistics provides many tools for studying the conditions of formulations and processes and enables us to optimize the same while being able to minimize our experimentation. The purpose of this study was to apply experimental design methodology (DOE) and multivariate analysis to the development and optimization of tablet formulations containing 150 mg lamiv

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3

Phillips, Justin. "Dextrin nanocomposites and deep eutectic solvents as matrices for solid dosage forms." Diss., University of Pretoria, 2020. http://hdl.handle.net/2263/81724.

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Controlled-release formulations for pesticide applications act as depot systems that continuously release the active ingredients into the environment over a speci ed period, usually from months to years. However, some applications require fast-dissolving drug delivery. The interest of this research is in fast-release of water-insoluble pesticides into aquatic environments. This study considered the use of dextrin starch and urea eutectics as fast release, solid dosage carrier forms that contain an active ingredient. The chosen active for this study is an acaricide called amitraz (N-methy

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4

Lopez, Lopez Felipe. "Better medicines for children : elucidating patient acceptability to guide flexible solid oral dosage form design." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10028121/.

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A medicine will not elicit its desired therapeutic effect if the patient is not able or willing to take it. The specific needs of the target population must be taken into account in the design of medicines. Evaluation of the effect of formulation factors on patient’s acceptability could guide the development of better medicines for children. Flexible solid oral dosage forms, including multiparticulates and (oro)dispersible formulations, offer advantages over conventional solid and liquid dosage forms to meet the needs of paediatric patients. These advantages include favourable stability profil

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5

Grout, B. F. "Novel applications of at-line near-infrared spectroscopy as process analytical technology for solid dosage form pharmaceutical analysis." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1395997/.

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The principal aim of this research was to assess at-line Near Infrared Spectroscopy (NIRS) to support Process Analytical Technology (PAT) applications within solid dosage form manufacturing. The history of PAT was traced from implementation of process analytical applications prior to the 2003 United States, Food and Drug Administration PAT initiative through to current time. The use of NIRS within the PAT context was reviewed, highlighting two areas in solid dosage manufacturing where further research of at-line NIRS is warranted; material testing and finished dosage form analysis. Novel appli

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6

Kindgen, Sarah M. [Verfasser]. "Hydrodynamics and solid dosage form disintegration/dissolution : immediate release tablets and novel in situ polyelectrolyte gastroretentive drug delivery systems / Sarah M. Kindgen." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2015. http://d-nb.info/1225749581/34.

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7

Yin, Xianzhen. "Structure Pharmaceutics Based on Synchrotron Radiation X-Ray Micro- Computed Tomography: From Characterization to Evaluation and Innovation of Pharmaceutical Structures." Thesis, University of Bradford, 2016. http://hdl.handle.net/10454/17378.

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Drug delivery systems (DDS) are essentially pharmaceutical products for human therapy, typically involving a mixture of active ingredients and excipients. Based upon quantitative characterization of structure, the thesis introduces the concept of classifying the architecture of DDS into four levels by their spatial scale and the life time period. The primary level is recognised as the static structure of the whole dosage form with a size from μm to cm with the final structure generated by formulation design. The secondary level categorises the structures of particles or sub-units to for

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8

MODICA, DE MOHAC Laura. "Novel Drug Delivery System for Treatment-Resistant Schizophrenia." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/478483.

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9

Ibrahim, Mohamed Asim Y. "Co-processing of drugs and co-crystal formers and its effect on pharmaceutical dosage-form performance. Co-crystallization of urea/ 2-methoxybenzamide, caffeine/ malonic acid, caffeine/ oxalic acid and theophylline/ malonic acid systems: Solid-state characterization including imaging, thermal, X-ray and Raman spectroscopic techniques with subsequent evaluation of tableting behaviour." Thesis, University of Bradford, 2008. http://hdl.handle.net/10454/12760.

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This dissertation has focused on the solid-state characterization of different co-crystal system as well as the effect of co-crystallization of these systems on pharmaceutical dosage form performance. Urea/ 2-MB, caffeine/ malonic acid, caffeine/ oxalic acid and theophylline/ malonic acid co-crystals were prepared using co-grinding- and co-precipitation techniques. In addition, the synthesis of co-crystals through two novel methods has been demonstrated. This includes compaction and convection mixing. The solid-state characterization of the co-crystals has been carried out using XRPD, Raman sp

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10

Ibrahim, Mohamed Asim Yousif. "Co-processing of drugs and co-crystal formers and its effect on pharmaceutical dosage-form performance : co-crystallization of urea/2-methoxybenzamide, caffeine/malonic acid, caffeine/oxalic acid and theophylline/malonic acid systems : solid-state characterization including imaging, thermal, X-ray and Raman spectroscopic techniques with subsequent evaluation of tableting behaviour." Thesis, University of Bradford, 2008. http://hdl.handle.net/10454/12760.

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This dissertation has focused on the solid-state characterization of different co-crystal system as well as the effect of co-crystallization of these systems on pharmaceutical dosage form performance. Urea/ 2-MB, caffeine/ malonic acid, caffeine/ oxalic acid and theophylline/ malonic acid co-crystals were prepared using co-grinding- and co-precipitation techniques. In addition, the synthesis of co-crystals through two novel methods has been demonstrated. This includes compaction and convection mixing. The solid-state characterization of the co-crystals has been carried out using XRPD, Raman sp

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11

Velásquez, Armijo Cristián Jesús. "Aplicação de métodos termo-analíticos e espectroscóspicos na avaliação do comportamento do fármaco isoniazida frente a adjuvantes tecnológicos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2003. http://hdl.handle.net/10183/144233.

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Os métodos termo-analíticos são ferramentas úteis na avaliação da compatibilidade entre fármacos e adjuvantes, com destaque à calorimetria exploratória diferencial. Neste trabalho foram avaliados a compatibilidade e o comportamento térmico entre a isoniazida e adjuvantes tecnológicos primários usualmente empregados em formas farmacêuticas sólidas. A compatibilidade foi examinada por meio da preparação de misturas físicas binárias do tipo fármaco/adjuvante. Foi investigada também a influência da granulação por via úmida e do processo de compactação para as misturas de isoniazida e adjuvantes co

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12

Grossová, Marie. "Tvorba biofilmu u probiotických bakterií a jejich zpracování do pevné lékové formy." Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2016. http://www.nusl.cz/ntk/nusl-263349.

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The aim of present work is cultivation of probiotic bacteria L. acidophilus, B. breve and B. longum in such a way that the culture forms cells clusters or comprehensive biofilm on the variety of free carriers. Biofilm formation of L. acidophilus on the silica from point of view bile and acid tolerance in gastrointestinal tract was studied. While the number of living cells in planktonic form (planktonic form) at pH 1 fell by 30 %, the viability of the biofilm cells was maintained to 90 % under the same environmental conditions. The biofilm culture showed also the protection against environment

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13

Shiko, Gentiana. "Quantitative and non-invasive studies of the dissolution behaviour of solid state pharmaceutics." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610272.

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14

Muschert, Susanne. "Polymeric coatings for solid dosage forms : characterization and optimization." Lille 2, 2008. http://www.theses.fr/2008LIL2S023.

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Les dispersions aqueuses de polymère sont couramment utilisées dans l'industrie pharmaceutique pour pelliculer les formes galéniques destinées à la voie orale et permettre une libération contrôlée du principe actif. Il est nécessaire de faire attention à la stabilité à long terme des films au cours du stockage et d'éviter une diminution des taux de principe actif libéré par continuation de la coalescence des particules de polymère. L'idée de ce travail était d'ajouter un second composant approprié aux dispersions aqueuses d'éthyle cellulose afin d'améliorer la formation du film et la stabilité

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15

Webster, Jessica Angela. "Assessment of amoxycillin suppositories." Thesis, Rhodes University, 1997. http://hdl.handle.net/10962/d1003280.

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The investigations in this dissertation have been 'conducted to investigate the formulation and analysis of a paediatric amoxycillin suppository. The oral administration of antibiotics to young children can at times be roblematic. Compliance is sometimes poor because of a sore throat, nausea, vomiting, a high fever or a dislike for the taste or smell of the medicine:- In-such cases the rectal administration of an antibiotic could provide an alternative route of administration that avoids some of the problems that affect oral administration. Difficulties associated with rectal administration ar

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16

Dunkley, SiaÌ‚n. "Adhesive and non-adhesive coatings for solid oral dosage-forms." Thesis, University of Portsmouth, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271371.

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17

Viboonkiat, Runglawan. "Methods to prepare amorphous material for rapid dissolution solid dosage forms." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406229.

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18

Kim, Won S. M. Massachusetts Institute of Technology. "Layer bonding of solvent-cast thin films for pharmaceutical solid dosage forms." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/65307.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 81-84).<br>In the pharmaceutical industry, the conventional tablet manufacturing process, a batch-based process based on solid powder handling, presents challenges such as inhomogeneous blending between Active Pharmaceutical Ingredients (APIs) and excipients, low yield, and low production rate. These difficulties can be resolved by the realization of a continuous manufacturing process through co-processing of APIs and e

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19

Gendrin, Christelle. "Chemical imaging and chemometrics for the analysis of pharmaceutical solid dosage forms." Université Louis Pasteur (Strasbourg) (1971-2008), 2008. https://publication-theses.unistra.fr/public/theses_doctorat/2008/GENDRIN_Christelle_2008.pdf.

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Des systèmes d'imagerie hyperspectrale ont été mis sur le marché pour l'analyse chimique microscopique et macroscopique. Constitués d'un détecteur plan présentant une matrice de pixels, ou d'un détecteur point lié à une plateforme mobile, ils peuvent acquérir des spectres localisés spatialement [. . . ]. Les données générées ont donc deux dimensions spatiales et une dimension spectrale, formant ainsi un cube de données. Elles permettent à la fois l'identification des constituants des échantillons et la visualisation de leur distribution spatiale. L'industrie pharmaceutique s'est vivement intér

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20

Gendrin, Christelle Hirsch Ernest. "Chemical imaging and chemometrics for the analysis of pharmaceutical solid dosage forms." Strasbourg : Université de Strasbourg, 2009. http://eprints-scd-ulp.u-strasbg.fr:8080/1031/01/GENDRIN_Christelle_2008.pdf.

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21

Knopp, Matthias Manne [Verfasser]. "Development of predictive tools for amorphous solid dosage forms / Matthias Manne Knopp." Mainz : Universitätsbibliothek Mainz, 2016. http://d-nb.info/1121045715/34.

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22

Kyobula, Mary. "Manufacturing of oral solid dosage forms using 3D inkjet printing." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/42980/.

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Ink-jet printing is a precise and versatile technique that accurately deposits small volumes of solutions (pico litres) in specific locations. Recently inkjet printing has attracted increasing attention in the pharmaceutical industry because of its ability to deliver low adjustable doses, variable drug release profiles and drug combinations suitable for the paradigm of personalised medicines. The significant growth in the aging population and the rise in the number of patients suffering from multiple chronic diseases are the key drivers. The current traditional tablet compression methods are l

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23

Andreis, Uilian de [UNESP]. "Farmacomagnetografia colônia: estudo in vitro da desintegração de comprimidos magnéticos revestidos." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/102442.

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Made available in DSpace on 2014-06-11T19:32:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-12-21Bitstream added on 2014-06-13T21:03:25Z : No. of bitstreams: 1 andreis_u_dr_botib.pdf: 1982280 bytes, checksum: 3d2499c3ae7d16a4f3593d5077238d10 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>A avaliação dos parâmetros motores do trato gastrintestinal é condição necessária para caracterizar o comportamento de formas farmacêuticas sólidas administradas pela via oral. A função motora gastrintestinal pode ser alterada em detrimento de doenças, interações com med

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24

Kolbina, Marina [Verfasser]. "Phospholipids as functional excipients in solid oral dosage forms / Marina Kolbina." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/117663867X/34.

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25

Blaesi, Aron H. "The design and manufacture of immediate-release optimal solid dosage forms." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/100862.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2014.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>Pharmaceutical manufacturing has traditionally been considered largely a matter of regulatory compliance. Consequently, it has been inefficient, but it is now increasingly being recognized as an opportunity for cost reduction. Recent initiatives by

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Corá, Luciana Aparecida [UNESP]. "A biosusceptometria AC aplicada à tecnologia farmacêutica." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/102448.

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Made available in DSpace on 2014-06-11T19:32:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-09-18Bitstream added on 2014-06-13T20:03:09Z : No. of bitstreams: 1 cora_la_dr_botib.pdf: 5114466 bytes, checksum: ae97ba77c87f4a9ec255be22db0f2b7f (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A administração oral de drogas é uma prática comum na terapia e as formas farmacêuticas sólidas são amplamente utilizadas. A variação no perfil de absorção ao longo do trato gastrintestinal (TGI) humano e a possibilidade de liberar drogas em diferentes regiões são os

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27

Bolognesi, Leandro. "Avaliação do tempo de trânsito esofágico de formas farmacêuticas sólidas pela cintilografia e biosusceptometria AC /." Botucatu : [s.n.], 2008. http://hdl.handle.net/11449/87775.

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Orientador: José Ricardo de Arruda Miranda<br>Banca: Luciana Aparecida Corá<br>Banca: Éder Rezende Moraes<br>Resumo: A administração oral de fármacos é uma prática comum na terapia e as formas farmacêuticas sólidas são amplamente utilizadas. O conhecimento sobre o trânsito de cápsulas e comprimidos no trato gastrointestinal é incompleto. Desse modo, avaliar o trânsito esofágico de farmacêuticas sólidas fornece um entendimento mais profundo sobre os mecanismos que desencadeiam a esofagite induzida por fármacos. Geralmente, os estudos de trânsito esofágico são realizados por meio da cintilografi

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28

Blair, Tina Caroline. "Some factors influencing the survival of microbial contamination in solid oral dosage forms." Thesis, King's College London (University of London), 1989. https://kclpure.kcl.ac.uk/portal/en/theses/some-factors-influencing-the-survival-of-microbial-contamination-in-solid-oral-dosage-forms(25307998-751d-4cb1-ae1b-49bf680e395c).html.

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29

Khaled, Shaban. "Extrusion based 3D printing as a novel technique for fabrication of oral solid dosage forms." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/38437/.

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Extrusion based three dimensional (3D) printing is defined as a process used to make a 3D object layer by layer directly from a computer aided device (CAD). The application of extrusion based 3D printing process to manufacture functional oral solid tablets with relatively complex geometries is demonstrated in this thesis. In Chapter 3 the viability of using a basic desktop 3D printer (Fab@Home) to print functional guaifenesin bilayer tablets (GBTs) is demonstrated. Guaifenesin is an over the counter (OTC) water soluble medicine used as expectorant for reduction of chest congestion caused by co

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30

Sefidaniforough, Ayda. "Investigating practices around medication administration to people with swallowing difficulties living in aged care facilities." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/132201/1/Ayda_Sefidaniforough_Thesis.pdf.

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Swallowing solid oral medications whole is a daily struggle for people who have swallowing difficulties. In aged care facilities, healthcare workers frequently modify medications for residents, e.g. crush tablets or open capsules, to make the medicines easier to administer, and swallow. These practices are not always safe and can put residents at risk of adverse effects. Through the use of interviews, surveys, and observations, this project investigated barriers and facilitators to giving medicines to aged care residents with swallowing difficulties, and then proposed the design of an interven

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31

Andreis, Uilian de. "Farmacomagnetografia colônia : estudo in vitro da desintegração de comprimidos magnéticos revestidos /." Botucatu : [s.n.], 2010. http://hdl.handle.net/11449/102442.

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Orientador: José Ricardo de Arruda Miranda<br>Banca: Luciana Aparecida Corá<br>Banca: Ricardo Brandit de Oliveira<br>Banca: Cristina Helena dos Reis Serra<br>Banca: José Ricardo Corrêa Saglietti<br>Resumo: A avaliação dos parâmetros motores do trato gastrintestinal é condição necessária para caracterizar o comportamento de formas farmacêuticas sólidas administradas pela via oral. A função motora gastrintestinal pode ser alterada em detrimento de doenças, interações com medicamentos ou intervenções cirúrgicas. Essas alterações, por sua vez, podem influenciar diversos processos farmacêuticos e,

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Maniruzzaman, Mohammed. "Development of hot-melt extrusion as a novel technique for the formulation of oral solid dosage forms." Thesis, University of Greenwich, 2012. http://gala.gre.ac.uk/9812/.

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Hot-melt extrusion (HME) is one of the most widely used technologies in the plastic, rubber and food industries and it has also been extensively explored and used in academia and the pharmaceutical industry over the last decade. This project aims to investigate the efficiency of hydrophilic polymers to enhance the dissolution rate of poorly water-soluble APIs processed by HME. Indomethacin (INM) and famotidine (FMT) were selected as model active substances while polyvinyl caprolactam graft copolymer, Soluplus® (SOL) and vinylpyrrolidone-vinyl acetate copolymer grades Kollidon® VA64 (VA64) and

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33

Bolognesi, Leandro [UNESP]. "Avaliação do tempo de trânsito esofágico de formas farmacêuticas sólidas pela cintilografia e biosusceptometria AC." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/87775.

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Made available in DSpace on 2014-06-11T19:23:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-10-30Bitstream added on 2014-06-13T18:09:06Z : No. of bitstreams: 1 bolognesi_l_me_botib.pdf: 259849 bytes, checksum: d7d575323f591bd0006aeb8a07bc7b2b (MD5)<br>Universidade Estadual Paulista (UNESP)<br>A administração oral de fármacos é uma prática comum na terapia e as formas farmacêuticas sólidas são amplamente utilizadas. O conhecimento sobre o trânsito de cápsulas e comprimidos no trato gastrointestinal é incompleto. Desse modo, avaliar o trânsito esofágico de farmacêuticas sólidas forn

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Corá, Luciana Aparecida. "A biosusceptometria AC aplicada à tecnologia farmacêutica /." Botucatu : [s.n.], 2008. http://hdl.handle.net/11449/102448.

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Orientador: José Ricardo de Arruda Miranda<br>Banca: Cristina Helena dos Reis Serra<br>Banca: Oswaldo Baffa Filho<br>Banca: Raul César Evangelista<br>Banca: Eryvaldo Sócrates Tabosa do Egyto<br>Resumo: A administração oral de drogas é uma prática comum na terapia e as formas farmacêuticas sólidas são amplamente utilizadas. A variação no perfil de absorção ao longo do trato gastrintestinal (TGI) humano e a possibilidade de liberar drogas em diferentes regiões são os maiores desafios para o desenvolvimento de novos produtos. Desse modo, avaliar formas farmacêuticas sólidas in vivo fornece um ent

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Ali, Rebaz [Verfasser]. "Oral Controlled-Release Solid Dosage Forms, Use of Novel Polymer and Unconventional Polymer Blends / Rebaz Ali." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1069290157/34.

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Kutza, Claudia [Verfasser], Karsten [Akademischer Betreuer] Mäder, Alfred [Akademischer Betreuer] Blume, and Benjamin [Akademischer Betreuer] Boyd. "“Solidified liquid lipids” for oral solid dosage forms : characterisation and processing / Claudia Kutza. Betreuer: Karsten Mäder ; Alfred Blume ; Benjamin Boyd." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2016. http://d-nb.info/1090786646/34.

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Wulff, Robert [Verfasser], and Claudia S. [Akademischer Betreuer] Leopold. "Development of polymer blend coatings for tailor-made drug release from solid dosage forms / Robert Wulff. Betreuer: Claudia S. Leopold." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2015. http://d-nb.info/107729560X/34.

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Wilson, Matthew Ryan. "The design and characterisation of novel multi-layer solid oral dosage forms manufactured using holt melt extrusion." Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675444.

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The aim of this thesis was to highlight the use of hot melt extrusion (HME) as a manufacturing process in the development of single and multi-dose, multi-layered solid oral dosage forms using celluloses to control drug release. Furthermore the ability of HME to be used as a technique to manufacture multi-layered tablets was analysed becoming cognisant of the factors that influence drug release from such systems. The impact of HME, polymer type, drug type, drug loading and tablet dimensions on the amount of drug released and the drug release mechanisms were defined and utilised to produce a cli

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El, Aita Ilias [Verfasser], Jörg [Gutachter] Breitkreutz, and Peter [Gutachter] Kleinebudde. "Manufacturing solid dosage forms using pressure-assisted microsyringe 3D-printing / Ilias El Aita ; Gutachter: Jörg Breitkreutz, Peter Kleinebudde." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1232490059/34.

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Matthews, Darren W. "Solid oral dosage forms of sparingly soluble compounds: enhancement of their release profiles to predict bioavailability of dissolution rate limited drugs." Thesis, Aston University, 2006. http://publications.aston.ac.uk/11034/.

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Two drugs, troglitazone and atovaquone, were selected based upon them being poorly soluble in aqueous media and being relatively lipophilic. These drugs were incorporated into solid dispersions, of various drug to polymer ratios, to improve their solubility. Three polymers were chosen to be the carrier in the solid dispersions; two gastric soluble polymers hydroxypropyl methylcellulose, polyvinylpyrrolidone and one enteric polymer, hydroxypropyl methylcellulose phthalate. Dissolution runs, in Fasted State Simulated Intestinal Fluid (FaSSIF), were performed upon the drugs, physical mixtures and

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Mado, George. "Using machine learning and multivariate predictive modelling to shorten dissolution time for solid dosage with the fully automated dissolution robot SingBATH." Thesis, KTH, Fiber- och polymerteknologi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-297658.

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Syftet med detta examensarbete är att förkorta 20-timmars frisättningen för en tablettformulering med förlängd frisättning genom att använda maskininlärning genom multivariat prediktiv modellering, helt automatisera frisättningsmetoden och utvärdera antalet tabletter som kan representera en batch vid frisättningsanalys av en specifik provtablett. Prediktionsmodellerna byggdes i SIMCA 14, som är en programvara för multivariat dataanalys. Två PLS-prediktionsmodeller byggdes som använder sig av de första 8 timmarna av frisättningen som X-variabler för att prediktera mängden aktiv farmaceutisk ing

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42

Gut, Yoann. "Imagerie par spectrométrie de masse MALDI et outils chimiométriques pour la cartographie de formes pharmaceutiques solides." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2012.

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L’agence européenne du médicament (EMA) stipule que les entreprises pharmaceutiques se doivent d’améliorer continuellement le contrôle de leur production afin de garantir la qualité des médicaments et préserver la santé des patients. Les outils analytiques classiques sont, par exemple, capables d’examiner l’intégralité d’un comprimé pharmaceutique pour contrôler la qualité et la quantité des substances actives utilisées et estimer leurs profils de libération dans l’organisme. Ils ne permettent cependant pas de cartographier la distribution des composés chimiques pourtant considérée comme un cr

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43

Laukamp, Eva Julia [Verfasser], Jörg [Akademischer Betreuer] Breitkreutz, and Peter [Akademischer Betreuer] Kleinebudde. "Melt Extruded Drug Formulations for Individual Dosing by the Solid Dosage Pen / Eva Julia Laukamp. Gutachter: Jörg Breitkreutz ; Peter Kleinebudde. Betreuer: Jörg Breitkreutz." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2015. http://d-nb.info/1069620157/34.

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Marinho, Jackeline de Souza. "Desenvolvimento de formas farmacêuticas sólidas contendo alto teor de produto seco por aspersão de frutos de Libidibia ferrea mart." Universidade Federal do Amazonas, 2016. http://tede.ufam.edu.br/handle/tede/5134.

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Submitted by Izabel Monteiro (izabel_22@hotmail.com) on 2016-08-03T15:40:38Z No. of bitstreams: 1 Dissertação - Jackeline de Souza Marinho.pdf: 2225410 bytes, checksum: 7a6f9be92271f2c88a3bc632cfead114 (MD5)<br>Approved for entry into archive by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2016-08-17T15:57:58Z (GMT) No. of bitstreams: 1 Dissertação - Jackeline de Souza Marinho.pdf: 2225410 bytes, checksum: 7a6f9be92271f2c88a3bc632cfead114 (MD5)<br>Approved for entry into archive by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2016-08-17T16:10:32

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Fischer, Dominique Corinne Hermine. "Contaminação microbiana em medicamentos fitoterápicos sob a forma sólida." Universidade de São Paulo, 1992. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-10072008-152345/.

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Foram analisados 84 lotes de especialidades fitoterápicas de uso oral, na forma de cápsula, comprimido e pó, contendo 17 drogas vegetais, produzidas por 20 fabricantes e comercializadas em farmácias, drogarias, lojas de produtos naturais e supermercados da cidade de são Paulo. O confronto da apresentação comercial das mesmas em relação à legislação nacional, indicou que a minoria (15/84) atendeu a tais exigências, além de ter demonstrado total falta de padronização de qualidade pelos produtores, inclusive com ausência de definição e conceituação, enquadrando-as indistintamente como medicamento

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Korte, Carolin [Verfasser], Jörg [Gutachter] Breitkreutz, Peter [Gutachter] Kleinebudde, and Julian [Akademischer Betreuer] Quodbach. "3D-Drug-Printing: Extrusion of Printable Drug-Loaded Filaments and Development of Novel Solid Dosage Forms / Carolin Korte ; Gutachter: Jörg Breitkreutz, Peter Kleinebudde ; Betreuer: Julian Quodbach." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2019. http://d-nb.info/1182032192/34.

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47

Wong, Yew Mun. "Improving recognition and management of swallowing difficulties with medicines." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/203193/1/Yew%20Mun_Wong_Thesis.pdf.

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This thesis looked at improving the screening and management of people who dislike swallowing solid oral medicines e.g. tablets and capsules. A novel screening tool was developed and validated to assist healthcare professionals in quickly identifying people who dislike swallowing tablets and capsules. A clinical trial was run to look at whether pill-swallowing aids made it easier for people to swallow tablets. The findings from the thesis may provide useful information with regards to managing people who dislike swallowing solid oral medicines, and information about pill-swallowing aids that a

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Deshmukh, Shivprasad S. "Investigation of injection moulding for novel drug delivery systems. An investigation into the use of injection moulding to produce pharmaceutical dosage forms and to understand the relationship between materials, processing conditions and performance, in particular drug release and stability." Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/14302.

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The feasibility of the injection moulding (IM) was explored for the development of novel drug delivery systems. Controlled release formulations were developed using a substituted cellulose derivative, hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and a graft co-polymer (Soluplus®). BCS class II drugs ibuprofen and the felodipine were selected based on their physicochemical properties. In the present work, a homogenous dispersion of drugs in the polymer matrices was achieved using Hot Melt Extrusion (HME) and extruded pellets obtained were used for the development of the injection

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Deshmukh, Shivprasad Shahajirao. "Investigation of injection moulding for novel drug delivery systems : an investigation into the use of injection moulding to produce pharmaceutical dosage forms and to understand the relationship between materials, processing conditions and performance, in particular drug release and stability." Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/14302.

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The feasibility of the injection moulding (IM) was explored for the development of novel drug delivery systems. Controlled release formulations were developed using a substituted cellulose derivative, hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and a graft co-polymer (Soluplus®). BCS class II drugs ibuprofen and the felodipine were selected based on their physicochemical properties. In the present work, a homogenous dispersion of drugs in the polymer matrices was achieved using Hot Melt Extrusion (HME) and extruded pellets obtained were used for the development of the injection m

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Joseph, Ashton Edward. "Comparison of the sutherlandioside B levels in two commercially available Sutherlandia frutescence preparations and the effect of elevated temperature and humidity on these levels." Thesis, University of the Western Cape, 2009. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_1532_1299237071.

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<p>Sutherlandia frutescens (tribe Galegeae, Fabaceae), is a popular medicinal plant traditionally used in South Africa. In 2000, a company called Phyto Nova (Pty) Ltd. initiated large-scale cultivation and contract manufacturing of tablets, made from the powdered herb (i.e. thin stems and leaves). Most of these commercial Sutherlandia solid dosage forms are made from the dried leaf powder but recently a new product, viz. Promune&trade<br>capsules, made from a freeze-dried aqueous extract, came on the market and was claimed to be &ldquo<br>better&rdquo<br>as it mimics the traditional tea. Howev

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