Relevant bibliographies by topics / Solid-Phase Peptide Synthesis; Spot Synthesis

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Academic literature on the topic 'Solid-Phase Peptide Synthesis; Spot Synthesis'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 February 2022

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Journal articles on the topic "Solid-Phase Peptide Synthesis; Spot Synthesis"

1

Li, Wenyi, John D. Wade, Eric Reynolds, and Neil M. O'Brien-Simpson. "Chemical Modification of Cellulose Membranes for SPOT Synthesis." Australian Journal of Chemistry 73, no. 3 (2020): 78. http://dx.doi.org/10.1071/ch19335.

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Since the development of solid-phase peptide synthesis in the 1960s, many laboratories have modified the technology for the production of peptide arrays to facilitate the discovery of novel peptide mimetics and therapeutics. One of these, known as SPOT synthesis, enables parallel peptide synthesis on cellulose paper sheets and has several advantages over other peptide arrays methods. Today, the SPOT technique remains one of the most frequently used methods for synthesis and screening of peptides on arrays. Although polypropylene and glass can be used for the preparation of peptide arrays, the
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2

De-Simone, Salvatore Giovanni, Larissa Rodrigues Gomes, Paloma Napoleão-Pêgo, Guilherme Curty Lechuga, Jorge Soares de Pina, and Flavio Rocha da Silva. "Epitope Mapping of the Diphtheria Toxin and Development of an ELISA-Specific Diagnostic Assay." Vaccines 9, no. 4 (2021): 313. http://dx.doi.org/10.3390/vaccines9040313.

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Background: The diphtheria toxoid antigen is a major component in pediatric and booster combination vaccines and is known to raise a protective humoral immune response upon vaccination. Although antibodies are considered critical for diphtheria protection, little is known about the antigenic determinants that maintain humoral immunity. Methods: One-hundred and twelve 15 mer peptides covering the entire sequence of diphtheria toxin (DTx) protein were prepared by SPOT synthesis. The immunoreactivity of membrane-bound peptides with sera from mice immunized with a triple DTP vaccine allowed mappin
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Swiontek, Wasko, Fraczyk, Galecki, Kaminski, and Kolesinska. "Insulin Hot-Spot Analogs Formed with N-Methylated Amino Acid Residues Inhibit Aggregation of Native Hormone." Molecules 24, no. 20 (2019): 3706. http://dx.doi.org/10.3390/molecules24203706.

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In this study, N-methylated analogs of hot-spots of insulin were designed and synthesized, in the expectation that they would inhibit the aggregation of both insulin hot-spots and the entire hormone. Synthesis of insulin “amyloidogenic” analogs containing N-methylated amino acid residues was performed by microwave-assisted solid phase according to the Fmoc/tert-Bu strategy. As a coupling reagent 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium toluene-4-sulfonate (DMT/NMM/TosO-) was used. Three independent methods were applied in aggregation studies of the complexes of insulin with it
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Lloyd-Williams, Paul, Fernando Albericio, and Ernest Giralt. "Convergent solid-phase peptide synthesis." Tetrahedron 49, no. 48 (1993): 11065–133. http://dx.doi.org/10.1016/s0040-4020(01)81800-7.

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LLOYD-WILLIAMS, PAUL, FERNANDO ALBERICIO, and ERNEST GIRALT. "Convergent solid-phase peptide synthesis." International Journal of Peptide and Protein Research 37, no. 1 (2009): 58–60. http://dx.doi.org/10.1111/j.1399-3011.1991.tb00733.x.

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KISO, YOSHIAKI, YOICHI FUJIWARA, TOORU KIMURA, AKIKO NISHITANI, and KENICHI AKAJI. "Efficient solid phase peptide synthesis." International Journal of Peptide and Protein Research 40, no. 3-4 (2009): 308–14. http://dx.doi.org/10.1111/j.1399-3011.1992.tb00306.x.

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Grandas, A., E. Pedroso, E. Giralt, C. Granier, and J. Van Rietschoten. "Convergent solid phase peptide synthesis IV." Tetrahedron 42, no. 24 (1986): 6703–11. http://dx.doi.org/10.1016/s0040-4020(01)82111-6.

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Le´ger, Roger, Rose Yen, Miles W. She, Ving J. Lee, and Scott J. Hecker. "N-Linked solid phase peptide synthesis." Tetrahedron Letters 39, no. 24 (1998): 4171–74. http://dx.doi.org/10.1016/s0040-4039(98)00777-1.

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Felix, Arthur M. "SOLID-PHASE PEPTIDE SYNTHESIS. Bruce Merrifield." Kobunshi 51, no. 8 (2002): 630–32. http://dx.doi.org/10.1295/kobunshi.51.630.

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Krchňák, Viktor, Josef Vágner, Martin Flegel, and Otakar Mach. "Continuous-flow solid-phase peptide synthesis." Tetrahedron Letters 28, no. 38 (1987): 4469–72. http://dx.doi.org/10.1016/s0040-4039(00)96541-9.

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Dissertations / Theses on the topic "Solid-Phase Peptide Synthesis; Spot Synthesis"

1

Jackson, Marcus J. "DESIGN OF A SCREENING PROCESS FOR THE DEVELOPMENT." Master's thesis, Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/202826.

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Chemistry<br>M.A.<br>We have initiated the development of a screening platform to design a library of small molecules on the same solid support surface. This solid support surface, and the chemistry involved, can be utilized as a means of developing lead target molecules, namely ligands and catalysts. Evidence shows the successful assembly of both simple amino acids, as well as successful employment of our synthetic compounds. We support our efforts by showing compatibility for binding studies with larger macromolecules. Thus, intrigue remains by the prospects of this project. Challenges withi
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Adamson, R. "Solid phase peptide synthesis." Thesis, University of Bradford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371460.

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Raphy, Gilles. "Solid phase peptide synthesis." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/14254.

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A new method of purification has been developed for peptides synthesised by the Merrifield solid phase methodology. N<SUP>PROB*LEM</SUP>-17-Tetrabenzo(a,c,g,i)fluorenylmethoxycarbonyl glycine (Tbfmoc Gly OH) has been prepared, and coupled <i>via</i> its symmetrical anhydride or its HOBt ester to the N-terminus of a peptide at the final stage of the synthesis. The strong affinity of the Tbfmoc group for graphitised carbon (PGC) allows the retention of Tbfmoc-protected peptides on a column packed with this material, whilst incorrectly terminated sequences and other materials are washed away. Fol
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Heine, Helge Niklas. "Peptidmimetika an Zellulosemembranen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2000. http://dx.doi.org/10.18452/14537.

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Die SPOT-Synthese an Zellulosemembranen wurde 1992 als eine hocheffiziente Methode zur parallelen Synthese von Peptiden beschrieben. Die wichtigste Anwendung der so synthetisierten Verbindungen ist das direkte Festphasen-Screening. Im Rahmen dieser Arbeit ist es gelungen, das Anwendungsgebiet der SPOT-Methode von Peptiden auf verschiedene Peptidmimetika auszudehnen und durch Screening entsprechender Bibliotheken bioaktive Substanzen zu identifizieren. (1) Peptoid-Synthese an Zellulosemembranen Die Ähnlichkeit von Oligo-N-alkylglycinen (Peptoiden) zu Peptiden sowie die Vereinbarkeit ihrer Sy
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McInnes, Campbell. "New methodology for solid phase peptide synthesis." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/12616.

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A novel linker for the solid phase synthesis of peptide amides is described. This linker based on 2-alkoxydibenzocycloheptadiene enables release of the peptide derivative under very mild conditions and is compatible with base labile N-alpha protecting groups. The efficacy of this linker in generating c-terminal peptide amides has been demonstrated in the synthesis of the natural products, little gastrin, big gastrin, substance P and bombesin. Modification of the linker allows peptide hydrazides to be prepared. The use of the linker in producing unprotected peptide hydrazides has been exemplifi
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Richards, Mark Ian. "Refined methods in solid (gel) phase peptide synthesis." Thesis, University of Wolverhampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343258.

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Dirscherl, Georg. "Solid-phase synthesis of peptide - metal-complex conjugates." kostenfrei, 2007. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/902/.

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Hewage, Gihan B. (Gihan Bhagye). "Advancements in polymer resins for solid-phase peptide synthesis." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/105055.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Chemistry, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 28-30).<br>The use of polymeric supports in solid-phase peptide synthesis has allowed for the facile, rapid synthesis of short peptides in a one bead/one sequence manner. This approach allows for screening peptide libraries for binding and catalytic activities. Once hits are found, the sequence of the active protein can be determined via mass spectrometry. However, problems arise when trying to create large libraries (on the
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Holland, David Richard. "Allylation of glycine equivalents during solid phase peptide synthesis." Thesis, University of Bath, 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311452.

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McIntyre, Denise Lynne. "Novel linkers for the solid-phase synthesis of peptide aldehydes." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/11846.

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Serine and cysteine proteases are potently inhibited by peptide aldehydes. Compared with the plethora of methods available for solution synthesis of peptide aldehydes, there are relatively few methods for the solid phase synthesis of peptide aldehydes. The development of novel linkers for the solid phase synthesis of peptide aldehydes is reported (Scheme 1). When X = N, the aldehyde 4 can be cleaved in mild acid with 97% enantiomeric excess (e.e.). When X = O, base hydrolysis results in aldehyde 4 cleavage with complete epimerisation of the α-stereocentre. The use of <i>Mucor meihei</i> lipase
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Books on the topic "Solid-Phase Peptide Synthesis; Spot Synthesis"

1

C, Sheppard R., ed. Solid phase peptide synthesis: A practical approach. IRL Press at Oxford University Press, 1989.

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Richards, Mark Ian. Refined methods in solid (gel) phase peptide synthesis. University of Wolverhampton, 2001.

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Coffey, Andrew Franklin. A new approach to computer controlled solid (gel) phase peptide synthesis. University of Wolverhampton, 1990.

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4

Butwell, Francis G. W. A 13C n.m.r. study of ultra-high-load solid (gel) phase peptide synthesis. The Polytechnic, Wolverhampton, School of Applied Sciences, 1988.

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Mole, Edward John. Side chain protecting strategies in ultra-high load solid (gel) phase peptide synthesis. ThePolytechnic, Wolverhampton, School of Applied Sciences, 1988.

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Life during a golden age of peptide chemistry: The concept and development of solid-phase peptide synthesis. American Chemical Society, 1993.

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Chan, W., and Peter White, eds. Fmoc Solid Phase Peptide Synthesis. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780199637256.001.0001.

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In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems outstanding at the time of publication of this earlier work have now been, for the most part, solved. As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures. The focus of this new volume is much broader, and covers not only the essential procedures for the production
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C, Chan Weng, and White Peter D, eds. Fmoc solid phase peptide synthesis: A practical approach. Oxford University Press, 2000.

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(Editor), W. C. Chan, and Peter D. White (Editor), eds. Fmoc Solid Phase Peptide Synthesis: A Practical Approach (Practical Approach Series). Oxford University Press, USA, 2000.

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Fmoc Solid Phase Peptide Synthesis: A Practical Approach (Practical Approach Series). Oxford University Press, USA, 2000.

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Book chapters on the topic "Solid-Phase Peptide Synthesis; Spot Synthesis"

1

Winkler, Dirk F. H. "SPOT Synthesis: The Solid-Phase Peptide Synthesis on Planar Surfaces." In Methods in Molecular Biology. Springer US, 2019. http://dx.doi.org/10.1007/978-1-0716-0227-0_10.

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Bodanszky, Miklos. "Solid Phase Peptide Synthesis." In Peptide Chemistry. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-97886-9_10.

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Bodanszky, Miklos. "Solid Phase Peptide Synthesis." In Peptide Chemistry. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-78206-0_10.

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Cudic, Mare, and Gregg B. Fields. "Solid-Phase Peptide Synthesis." In Springer Protocols Handbooks. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-60327-375-6_32.

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Merrifield, R. B. "Solid-Phase Peptide Synthesis." In Advances in Enzymology - and Related Areas of Molecular Biology. John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/9780470122778.ch6.

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Fields, Gregg B. "Solid-Phase Peptide Synthesis." In Springer Protocols Handbooks. Humana Press, 1998. http://dx.doi.org/10.1007/978-1-59259-642-3_42.

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Winkler, Dirk F. H. "Automated Solid-Phase Peptide Synthesis." In Methods in Molecular Biology. Springer US, 2019. http://dx.doi.org/10.1007/978-1-0716-0227-0_5.

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Hansen, Paul R., and Alberto Oddo. "Fmoc Solid-Phase Peptide Synthesis." In Methods in Molecular Biology. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2999-3_5.

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Albericio, Fernando, Paul Lloyd-Williams, Margarida Gairí, Gemma Jou, Ramon Eritja, and Ernest Giralt. "Convergent solid-phase peptide synthesis." In Peptides. Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2264-1_240.

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Soomets, Ursel, Mihkel Zilmer, and lo Langel. "Manual Solid Phase Synthesis of Glutathione Analogs." In Peptide Synthesis and Applications. Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-877-3:241.

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Conference papers on the topic "Solid-Phase Peptide Synthesis; Spot Synthesis"

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Barany, George. "Orthogonal Solid-Phase Peptide Synthesis." In The 24th American Peptide Symposium. Prompt Scientific Publishing, 2015. http://dx.doi.org/10.17952/24aps.2015.001.

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Turcotte, Stéphane, and William D. Lubell. "Solid-Phase Synthesis of Azasulfurylphenylalanine4-GHRP-6." In The 24th American Peptide Symposium. Prompt Scientific Publishing, 2015. http://dx.doi.org/10.17952/24aps.2015.040.

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de la Torre, Beatriz G., Ashish Kumar, Yahya Jad, et al. "Solid-phase peptide synthesis: the Greener, the Better." In 35th European Peptide Symposium. Prompt Scientific Publishing, 2018. http://dx.doi.org/10.17952/35eps.2018.099.

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Pomo-Villar, Esteban, Encarnacion Nogueira, Maria del Carmen Fernandez, et al. "Synthesis of Protected Thiophospho Amino Acids for Solid Phase Peptide Synthesis." In The 1st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1997. http://dx.doi.org/10.3390/ecsoc-1-02027.

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Merrifield, Bruce. "Solid phase peptide synthesis: New chemistry and new directions." In Future Aspect in Peptide Chemistry - Ringberg Conference. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199901012.

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Traore, Mariam, and William D. Lubell. "Solid-Phase Synthesis of Aza-Lysine Peptide Analogue of Trypsin Substrate." In The 24th American Peptide Symposium. Prompt Scientific Publishing, 2015. http://dx.doi.org/10.17952/24aps.2015.202.

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Ciencialová, Alice, Lenka Klasová, Jiří Jiráček, Jana Barthová, and Tomislav Barth. "Fluorescent labeled amino acid utilizable in solid phase peptide synthesis." In VIIth Conference Biologically Active Peptides. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2001. http://dx.doi.org/10.1135/css200104041.

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Mahmoodi, Mohammad M., Tomohiro Kubo, Daniel Abate-Pella, Jane E. Wissinger, and Mark D. Distefano. "Solvent-Free Synthesis of Bhc-Cl and Application to Cysteine Protection in Solid Phase Peptide Synthesis." In The Twenty-Third American and the Sixth International Peptide Symposium. Prompt Scientific Publishing, 2013. http://dx.doi.org/10.17952/23aps.2013.248.

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Fuente-Moreno, M., A. Oddo, M. Sheykhzade, D. S. Pickering, and P. R. Hansen. "Fmoc Solid-Phase Peptide Synthesis of Human alfa-Calcitonin Gene-Related Peptide and Two Fluorescent Analogs." In The 24th American Peptide Symposium. Prompt Scientific Publishing, 2015. http://dx.doi.org/10.17952/24aps.2015.264.

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Niethammer, Felix, Daniel Maisch, and Marcus Rothe. "Evaluation of the ”ResPep continuousflow synthesizer” with real-time UVmonitoring, automated feedback & heating in solid phase peptide synthesis." In 35th European Peptide Symposium. Prompt Scientific Publishing, 2018. http://dx.doi.org/10.17952/35eps.2018.116.

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Reports on the topic "Solid-Phase Peptide Synthesis; Spot Synthesis"

1

Vouros, Paul, and Terrance Black. Solid Phase Peptide Synthesis of Antimicrobial Peptides for cell Binding Studies: Characterization Using Mass Spectrometry. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada412571.

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