Relevant bibliographies by topics / Solitary Plasmacytoma of Bone

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Academic literature on the topic 'Solitary Plasmacytoma of Bone'

Author: Grafiati
Published: 7 June 2025
Last updated: 16 July 2025

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Journal articles on the topic "Solitary Plasmacytoma of Bone"

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Majumdar, S., U. Raghavan, and N. S. Jones. "Solitary plasmacytoma and extramedullary plasmacytoma of the paranasal sinuses and soft palate." Journal of Laryngology & Otology 116, no. 11 (2002): 962–65. http://dx.doi.org/10.1258/00222150260369561.

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Solitary plasmacytoma of the paranasal sinuses are uncommon neoplasms of B lymphocyte origin. They comprise one per cent of all head and neck tumours of the upper respiratory tract. They can be solitary plasmacytomas of the bone (SPB), an extramedullary plasmacytoma or a local manifestation of multiple myeloma. Conversion to multiple myeloma happens more frequently in SPB. Radiotherapy is the common modality of treatment with, or without, adjuvant chemotherapy. Extramedullary plasmacytoma carries a better prognosis than a solitary plasmacytoma of the bone. We report four cases of solitary plasmacytoma of the bone and an extramedullary plasmacytoma of the paranasal sinuses and soft palate.
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Humail, Syed Mujahid, Masroor Ahmed, Ghulam Mustafa K.K, Muhammad Bux, and Hassan Dost Afridi. "SOLITARY PLASMACYTOMA." Professional Medical Journal 21, no. 01 (2018): 229–31. http://dx.doi.org/10.29309/tpmj/2014.21.01.1917.

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Solitary plasmacytoma of bone is one of the subtypes of plasma cell neoplasms.Solitary plasmacytoma is a kind of malignant tumor characterized by localized collection ofmonoclonal plasma cells. It is most frequently seen in vertebrae and long bones. Plasmacytomaof clavicle is very rare. We report a case of solitary plasmacytoma of lateral end of clavicle in a 30year old male presented with complaint of pain and swelling around the right shoulder region,though SPB can involve any bone of body but SPB involving the lateral end of clavicle is very rarepresentation.
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Rahman, Md Atikur, Aklaque Hossain Khan, and Kanak Kanti Barua. "Pulsatile Midline Solitary Plasmacytoma in the Frontal Head Region-A Case Report”." Bangladesh Journal of Neuroscience 32, no. 1 (2016): 39–42. http://dx.doi.org/10.3329/bjn.v32i1.57412.

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Primary craniocerebral plasmacytomas are uncommon and represent only 0.7 % of all plasmacytomas. In this case solitary plasmacytoma in the midline frontal head region of the skull and discuss the clinical features and prognosis of this tumor. Plasmacytoma can present as multiple myeloma, solitary plasmacytoma of the bone or extramedullary plasmacytoma. Solitary plasmacytoma is a rare entity that composes of malignant plasma cells and involves the bone to form only one or two lesions without evidence of disease dissemination. It accounts for only 4% of malignant plasma cell tumors. 50 years old male was suffering from plasmacytoma in the frontal head region in our case which is pulsatile. On images showed multiple differential diagnosis but after operation histological examination revealed plasmacytoma.
 Bangladesh Journal of Neuroscience 2016; Vol. 32 (1): 39-42
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Akbar, Ahna Ali, Anu Abhilash, and Mayeesh Radhakrishna. "Solitary plasmacytoma masquerading as a benign lesion." Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology 9, no. 3 (2023): 150–54. http://dx.doi.org/10.18231/j.jooo.2023.033.

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Plasmacytoma refers to a distinct and localized growth of plasma cells that are neoplastic and monoclonal in nature. Solitary plasmacytomas (SP) can be categorized into two groups based on their location: solitary bone plasmacytoma (SBP), which most commonly occurs in the vertebrae and secondarily in long bones, and extramedullary plasmacytoma (EMP), encompassing SPs found outside the bone. Long bones are frequently affected in solitary plasmacytomas. SBP specifically in the jaw is a rare condition, leading to challenges in diagnosis and often resulting in misdiagnosis. SBP carries a higher risk of progression to myeloma, and the primary treatment option is radiotherapy (RT). By employing RT alone, approximately 30% of SBP patients and 65% of EMP patients can achieve long-term disease-free survival (DFS). This article presents a case of a 40-year-old female patient diagnosed with solitary plasmacytoma of the mandible, with detailed documentation of clinical, radiographic, and histological features.
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McCormack, Sean, Eyad Hamad, and Amar Hamad. "Solitary Plasmacytoma of the Breast: A Case of an Uncommon Breast Neoplasm." Case Reports in Hematology 2023 (June 3, 2023): 1–5. http://dx.doi.org/10.1155/2023/9622042.

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Plasmacytoma is a rare cancer that originates from a single plasma cell and is characterized by the abnormal proliferation of monoclonal plasma cells. It is typically localized in a single area of the body, most commonly in the bone or soft tissue. Solitary plasmacytoma can be further classified as either solitary plasmacytoma of bone (SPB) or solitary extramedullary plasmacytoma (SEP or EMP). Diagnosis may be delayed in symptomatically silent plasmacytomas, but early diagnosis and prompt treatment are crucial for the management of this disease. The mean age for patients with plasmacytoma varies depending on the specific type of plasmacytoma, but generally, it is more common in older adults. Soft tissue plasmacytomas are uncommon, and plasmacytomas manifesting within the breast are extremely rare, especially when they are not a manifestation of multiple myeloma (MM). This report presents a case of SEP of the breast in a 79-year-old female patient. This rare disease needs to be studied further in terms of long-term survival and disease progression to MM. By raising awareness and understanding of plasmacytoma, we aim to improve outcomes and quality of life for patients affected by this disease.
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Kumar, Shaji, Rafael Fonseca, Angela Dispenzieri, et al. "Prognostic value of angiogenesis in solitary bone plasmacytoma." Blood 101, no. 5 (2003): 1715–17. http://dx.doi.org/10.1182/blood-2002-08-2441.

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Angiogenesis plays an important role in the biology of multiple myeloma (MM) and has prognostic importance in this disease. Solitary plasmacytoma is a localized plasma cell malignancy that progresses to MM in a significant number of patients. We examined if angiogenesis is increased in solitary plasmacytoma and if it can help identify patients likely to progress to myeloma. We studied angiogenesis in plasmacytoma biopsy samples and bone marrow biopsies from 25 patients. High-grade angiogenesis was present in 64% of plasmacytomas. In contrast, bone marrow angiogenesis was low in all patients. Patients with high-grade angiogenesis in the plasmacytoma sample were more likely to progress to myeloma and had a shorter progression-free survival compared with patients with low-grade angiogenesis (P = .02). Angiogenesis is increased in solitary plasmacytoma and is a significant predictor of progression to myeloma and provides further evidence of its importance in the pathogenesis of myeloma.
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Ng, Calvin SH, and Kelvin KW Lau. "Solitary Bone Plasmacytoma." Canadian Respiratory Journal 20, no. 1 (2013): 11. http://dx.doi.org/10.1155/2013/469876.

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Bannur, HB, and VM Dhorigol. "Solitary bone plasmacytoma." Journal of Cytology 21, no. 3 (2004): 163. http://dx.doi.org/10.4103/0970-9371.238317.

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Grammatico, Sara, Emilia Scalzulli, and Maria Teresa Petrucci. "SOLITARY PLASMACYTOMA." Mediterranean Journal of Hematology and Infectious Diseases 9, no. 1 (2017): e2017052. http://dx.doi.org/10.4084/mjhid.2017.052.

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Solitary plasmacytoma is a rare disease characterized by a localized proliferation of neoplastic monoclonal plasma cells, without evidence of systemic disease. It can be subdivided into solitary bone plasmacytoma, if the lesion originates in bone, or solitary extramedullary plasmacytoma, if the lesion involves a soft tissue. Incidence of solitary bone plasmacytoma is higher than solitary extramedullary plasmacytoma. Also prognosis is different: even if both forms respond well to treatment, overall survival and progression free survival of solitary bone plasmacytoma is poorer than solitary extramedullary plasmacytoma due to its higher rate of evolution in multiple myeloma. However, the recent advances in the diagnosis of multiple myeloma can better refine also the diagnosis of plasmacytoma. Flow cytometry studies and molecular analysis may reveal clonal plasma cells in the bone marrow; magnetic resonance imaging or 18 Fluorodeoxyglucose positron emission tomography could better define osteolytic bone lesions. A more precise exclusion of eventual occult systemic involvement can avoid cases of misdiagnosed multiple myeloma patients, that were previously considered solitary plasmacytoma and less treated, with an unavoidable poor prognosis.Due to the rarity of the disease, there is no uniform consensus about prognostic factors and treatment. Radiotherapy is the treatment of choice; however, some authors debates about the radiotherapy dose and the relationship with the response rate. Moreover, the role of surgery and chemotherapy is still under debate. Nevertheless, we must consider that the majority of studies include a small number of patients and analyze the efficacy of conventional chemotherapy; few cases are reported concerning the efficacy of novel agents.Keywords: solitary plasmacytoma; myeloma; radiotherapy; osteolytic lesions
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Sofa, Maya, Maman Abdurahman, Kiki A. Rizky, et al. "Case Series of Rare Head and Neck Plasmacytoma: Experiences in Indonesia." Bioscientia Medicina : Journal of Biomedicine and Translational Research 7, no. 9 (2023): 3609–19. http://dx.doi.org/10.37275/bsm.v7i9.867.

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Background: Solitary plasmacytoma (SP) is a rare case of plasma cell neoplasms, which only represent 5-10% of all plasma cell neoplasms that afflict two or three people per every 100,000 of the general population. This neoplasm is divided into solitary plasmacytoma of the bone (SBP) and solitary extramedullary plasmacytoma (SEP), depending on the location. Due to the rarity, SBP can be misdiagnosed as multiple myeloma (MM) while SEP as plasma cell granuloma, whereas the treatments are very different. This study aimed to present our experiences in diagnosing SP in the head and neck to differentiate them from MM and plasma cell granuloma.
 Case presentation: One case of multiple solitary plasmacytomas of the bone (SPB) in the frontal bone and one case of intraoral solitary extramedullary plasmacytoma (SEP) were presented. The SBP showed abnormality in the laboratory and the CT showed a punch-out lesion which is similar to MM. The SEP showed normal laboratory findings, but the histopathology mimicked plasma cell granuloma. Both immunohistochemistry was positive for CD138, and the SEP diagnosis was confirmed by Ki67 and κ-light chain. Complete examination from history taking, physical examination, radiology and laboratory findings, bone marrow morphology, and histopathology including immunohistochemistry examination, are very important to determine the correct diagnosis.
 Conclusion: the case was diagnosed as head and neck solitary plasmacytoma.
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Dissertations / Theses on the topic "Solitary Plasmacytoma of Bone"

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Dashti, Mahdi. "Non- epithelial bone cysts of the jaw." University of the Western Cape, 2020. http://hdl.handle.net/11394/7528.

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>Magister Scientiae - MSc<br>Aneurysmal Bone Cysts (ABC) and Solitary Bone Cysts (SBC), both non-epithelial cysts of the jaws are defined as benign lesions of an unclear aetiology. There is limited literature available on these two primary non-epithelial cysts of the jaws, especially in African populations. This retrospective study focused on the clinical and radiographic features, as well as management of the non-epithelial cysts of the jaws presenting at the University of the Western Cape Oral Health Centre from 1970-2018. The aim of this study was to describe the clinical and radiological features of non-epithelial cysts of the jaws that presented at the Departments of Maxillo-Facial and Oral Surgery and Diagnostics and Radiology at the University of the Western Cape Oral Health Centre as well as their management and recurrence patterns.
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Xu, Linlin. "CD166 modulates disease progression and osteolytic disease in multiple myeloma." Diss., 2016. http://hdl.handle.net/1805/10477.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Multiple myeloma (MM) is an incurable malignancy characterized by the proliferation of neoplastic plasma cells in the bone marrow (BM) and by multiple osteolytic lesions throughout the skeleton. We previously reported that CD166 is a functional molecule on normal hematopoietic stem cells (HSC) that plays a critical role in HSC homing and engraftment, suggesting that CD166 is involved in HSC trafficking and lodgment. CD166, a member of the immunoglobulin superfamily capable of mediating homophilic interactions, has been shown to enhance metastasis and invasion in several tumors. However, whether CD166 is involved in MM and plays a role in MM progression has not been addressed. We demonstrated that a fraction of all human MM cell lines tested and MM patients’ BM CD138+ cells express CD166. Additionally, CD166+ cells preferentially home to the BM of NSG mice. Knocking-down (KD) CD166 expression on MM cells with shRNA reduced their homing to the BM. Furthermore, in a long-term xenograft model, NSG mice inoculated with CD166KD cells showed delayed disease progression and prolonged survival compared to mice receiving mock transduced cells. To examine the potential role of CD166 in osteolytic lesions, we first used a novel Ex Vivo Organ Culture Assay (EVOCA) which creates an in vitro 3D system for the interaction of MM cells with the bone microenvironment. EVOCA data from MM cells lines as well as from primary MM patients’ CD138+ BM cells demonstrated that bone osteolytic resorption was significantly reduced when CD166 was absent on MM cells or calvarial cells. We then confirmed our ex vivo findings with intra-tibial inoculation of MM cells in vivo. Mice inoculated with CD166KD cells had significantly less osteolytic lesions. Further analysis demonstrated that CD166 expression on MM cells alters bone remodeling by inhibiting RUNX2 gene expression in osteoblast precursors and increasing RANKL to OPG ratio in osteoclast precursors. We also identified that CD166 is indispensable for osteoclastogenesis via the activation of TRAF6-dependent signaling pathways. These results suggest that CD166 directs MM cell homing to the BM and promotes MM disease progression and osteolytic disease. CD166 may serve as a therapeutic target in the treatment of MM.
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Books on the topic "Solitary Plasmacytoma of Bone"

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Cassidy, Jim, Donald Bissett, Roy A. J. Spence OBE, Miranda Payne, and Gareth Morris-Stiff. Malignancy of unknown primary. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199689842.003.0026.

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Bone and soft tissue malignancies describes a large group of sarcomas, some of which require highly specialist management, including osteosarcoma, Ewing’s sarcoma, and rhabdomyosarcoma, so that referral to an appropriate multidisciplinary team (MDT) is mandatory. Limb conserving surgery combined with pre- and postoperative chemotherapy is curative in the majority of osteosarcomas, and similar approach which may include local radiotherapy also holds for Ewing’s. Other primary bone tumours are reviewed including malignant fibrous histiocytoma, chondrosarcoma, chordoma, solitary plasmacytoma, and primary lymphoma of bone.Soft tissue sarcomas comprise a heterogeneous group of tumours, ranging from low grade pathology with at worst propensity to local recurrence after conservative surgery, to high grade disease (including extra osseous Ewing’s) where intensive chemotherapy along with surgery is standard therapy. Pre-or postoperative radiotherapy improves local control for many soft tissue sarcomas. For most soft tissue sarcomas, chemosensitivity is modest at best, offering palliative benefit in metastatic disease, but no clear survival benefit in adjuvant therapy. Gastrointestinal stromal tumours and a few others are susceptible to targeted therapy, and it is hoped that this approach may be applicable to more in the future.Metastatic disease from both bone and soft tissue sarcomas is often pulmonary, and metastectomy can provide effective treatment, particularly when lung lesion is solitary.
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Collins, Graham, and Chris Bunch. Multiple myeloma and related conditions. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0290.

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Multiple myeloma is a cancerous disorder of the bone marrow and arises from a clonal proliferation of plasma cells, resulting in end-organ damage (e.g. renal failure, hypercalcaemia, bone disease, and bone marrow failure). When a plasma cell clone is only detected in one site (either bony or soft tissue), it is termed a plasmacytoma. Monoclonal gammopathy of uncertain significance is also a clonal proliferation of plasma cells but, by definition, does not result in end-organ damage. This chapter addresses the diagnosis and management of multiple myeloma.
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Newell-Price, John, Alia Munir, and Miguel Debono. Primary hyperparathyroidism. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0187.

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Primary hyperparathyroidism is a disorder of bone mineralization and renal physiology due to excess parathyroid hormone secretion. Parathyroid hormone (PTH) is produced and released by the parathyroid chief cells, under regulation of the G- protein-coupled calcium-sensing receptor. Primary hyperparathyroidism occurs when there is a loss of the inhibitory feedback of PTH release by extracellular calcium. The rise in PTH levels is initially associated with a normal serum calcium, and then over time with hypercalcaemia. The most common cause of primary hyperparathyroidism is a benign solitary adenoma (80%). Other causes include multiple adenomas and hyperplasia. This chapter reviews the causes, clinical features, and management of primary hyperparathyroidism.
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Book chapters on the topic "Solitary Plasmacytoma of Bone"

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Bahk, Won-Jong. "Solitary Plasmacytoma." In Diagnosis and Management of Primary Bone Tumors. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-5498-8_7.

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He, Yue, Hui Shan Ong, Zhen Tian, Lin Zhu, and Xiao Guang Li. "Solitary Plasmacytoma of Bone." In Inflammatory and Neoplastic Diseases of Craniofacial Bones. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-4155-7_53.

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Lust, John A. "Solitary Plasmacytoma of Bone and Extramedullary Plasmacytoma." In Hematologic Malignancies: Multiple Myeloma and Related Plasma Cell Disorders. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-662-08885-2_4.

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Walker, Ronald C., Laurie Jones-Jackson, Twyla Bartel, Tracy Brown, and Bart Barlogie. "Imaging of Multiple Myeloma, Solitary Plasmacytoma, MGUS, and Other Plasma Cell Dyscrasias." In Myeloma Bone Disease. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-554-5_2.

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Dingli, David, and Prashant Kapoor. "Solitary Plasmacytoma." In Multiple Myeloma. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8520-9_16.

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Order, Stanley E., and Sarah S. Donaldson. "Plasmacytoma(Solitary)." In Radiation Therapy of Benign Diseases. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-58719-1_89.

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Jensen, Lindsay G., Loren K. Mell, Christin A. Knowlton, et al. "Solitary Plasmacytoma." In Encyclopedia of Radiation Oncology. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_1256.

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Tsang, R. W. "Solitary plasmacytoma." In Management of Rare Adult Tumours. Springer Paris, 2009. http://dx.doi.org/10.1007/978-2-287-92246-6_60.

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Moulopoulos, Lia A., and Meletios A. Dimopoulos. "Solitary Plasmacytoma." In Radiological Imaging in Hematological Malignancies. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-18832-9_17.

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Campanacci, Mario, Franco Bertoni, and Patrizia Bacchini. "Plasmacytoma." In Bone and Soft Tissue Tumors. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-29279-2_34.

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Conference papers on the topic "Solitary Plasmacytoma of Bone"

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Fernandes, Tatiana Melo, Mariana DOliveira Bulhões da Costa, Bartira Souza Melo, et al. "SOLITARY BONE PLASMACYTOMA MIMICKING RHEUMATOID ARTHRITIS AS AN ATYPICAL PRESENTATION." In XL Congresso Brasileiro de Reumatologia. Sociedade Brasileiro de Reumatologia, 2023. http://dx.doi.org/10.47660/cbr.2023.1811.

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Schreiner, Sabine, Agmal Scherzad, Matthias Scheich, Stephan Hackenberg, and Thomas Gehrke. "Extramedullary manifestations of multiple Myeloma and solitary Plasmacytomas in the head and neck region." In 95th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e. V., Bonn. Georg Thieme Verlag KG, 2024. http://dx.doi.org/10.1055/s-0044-1784671.

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Velagapudi, R. K., and G. Cumbo-Nacheli. "An Unusual Cause of Hoarseness: Solitary Extramedullary Plasmacytoma Presenting as a Mediastinal Mass." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5834.

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Stawovy, L. E., E. Rojas, V. Badami, et al. "Massive Intrathoracic Amyloidoma from an Untreated Solitary Plasmacytoma: A Decade in the Making." In American Thoracic Society 2022 International Conference, May 13-18, 2022 - San Francisco, CA. American Thoracic Society, 2022. http://dx.doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5517.

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Lamb, Meredith M., Abdullah Zeatoun, Taylor Stack-Pyle, et al. "Solitary Plasmacytoma of the Head and Neck: Case Series and Review of the Literature." In 32nd Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2023. http://dx.doi.org/10.1055/s-0043-1762309.

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Esteban, Jorge Illarramendi, Ivan Quispe, Mercedes Rodriguez, et al. "BREAST PLASMACYTOMA: A CASE TREATED WITH IRRADIATION THAT EVOLVED TO FURTHER BILATERAL BREAST INVOLVEMENT AND SYSTEMIC DISEASE REFRACTORY TO CHEMOTHERAPY." In Brazilian Breast Cancer Symposium 2022. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s2078.

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Introduction: Plasmacytomas are uncommon malignant lesions in the breast. Further knowledge is needed about the presentation, diagnosis, and therapy of this disease. Case report: A 78-year-old woman had a previous diagnosis of sacral bone plasmacytoma in March 2005 that was treated with radiotherapy. A new lesion involved in the cervical spine in 2008 was also irradiated. A mammogram and ultrasound found two well-defined nodules in January 2012 in the upper outer quadrant of the right breast, with a total diameter of 38 mm. Biopsy showed a proliferation of cells with Ki-67 staining in more than 90% and positivity for CD38, CD138, CD45, and CD79A, an exclusive expression of lambda light chains. The pathological diagnosis was anaplastic plasmacytoma. She received radiotherapy with remission of the breast lesions. After further appearance of bone lesions, she started chemotherapy with bortezomib, melphalan, and prednisone in January 2016. A PET study in July 2016 showed, among other findings, the presence of a 4-cm lesion in the upper-outer quadrant of the left breast (SUVmax: 3.9). Biopsy gave a diagnosis of plasmacytoma, with cells staining strongly positive for CD138, MUN1, and CD38, with the expression of lambda light chain. Chemotherapy was changed to lenalidomide plus dexamethasone. A further PET in January 2017 displayed, among other findings, the persistence of the lesion in the left breast (SUVmax: 5.4) with two new lesions in the right breast (SUVmax: 5.3 and 13). There was also a sacral progression, and chemotherapy was changed to pomalidomide, dexamethasone plus cyclophosphamide. The evolution of the patient was unfavorable, and she died in June 2017. Criteria for multiple myeloma were not present along the course of the disease. Conclusion: Evolution to bilateral involvement, relapse in the same breast, and refractoriness to chemotherapy are remarkable aspects of this case report and give further information about this presentation of the disease.
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Wong, Brandon, and Katherine Liu. "Solitary Bone Lesions: A Breakdown Of The Bone-RADS V2023 Risk Stratification System For Radiographic Imaging." In Radiopaedia 2024 Virtual Conference. Radiopaedia.org, 2024. http://dx.doi.org/10.53347/rposter-2468.

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Vidoni, A., and A. Saifuddin. "Diagnostic Accuracy of CT-Guided Core Needle Biopsy for Solitary Bone Lesions in Pediatric Patients." In ESSR 2020 Virtual Meeting. Thieme Medical Publishers, Inc., 2020. http://dx.doi.org/10.1055/s-0040-1722507.

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Temiyasathit, Sara, Ronald Y. Kwon, Padmaja Tummala, Clarence C. Quah, and Christopher R. Jacobs. "Adenylyl Cyclase 6 Mediates Primary Cilia-Dependent Changes in Cyclic Adenosine Monophosphate in Response to Dynamic Fluid Flow." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206200.

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It is well accepted that fluid flow is an important mechanical signal in regulating bone structure and function. Primary cilia, which are solitary, microtubule-based organelles that extend from the centrosome into extracellular space in many cell types, have been shown to mediate fluid flow-induced osteogenic responses in MLO-Y4 osteocyte-like cells [1], however, primary cilia did not mediate increases in intracellular Ca2+ concentration [1]. Recently, we identified cAMP as a novel early signaling molecule in primary cilia-dependent mechanotransduction of fluid flow in osteocytes. Specifically, we show that MLO-Y4 osteocyte-like cells respond to oscillatory flow with a rapid decrease in intracellular levels of cAMP that is dependent on the primary cilium [2]. Adenylyl cyclase 6 (AC6) is an enzyme responsible for the synthesis of cAMP from ATP. We found that AC 6 localizes to the primary cilium of bone cells (Fig. 1). In this study, our goal was to determine whether AC6 mediates the primary cilia-dependent, flow-induced decrease in cAMP.
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Reports on the topic "Solitary Plasmacytoma of Bone"

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Nelson, Brenda L. Solitary Bone Cyst. Defense Technical Information Center, 2010. http://dx.doi.org/10.21236/ada520056.

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