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Journal articles on the topic 'Solubility'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Lajoie, Léo, Anne-Sylvie Fabiano-Tixier, and Farid Chemat. "Water as Green Solvent: Methods of Solubilisation and Extraction of Natural Products—Past, Present and Future Solutions." Pharmaceuticals 15, no. 12 (2022): 1507. http://dx.doi.org/10.3390/ph15121507.

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Water is considered the greenest solvent. Nonetheless, the water solubility of natural products is still an incredibly challenging issue. Indeed, it is nearly impossible to solubilize or to extract many natural products properly using solely water due to their low solubility in this solvent. To address this issue, researchers have tried for decades to tune water properties to enhance its solvent potential in order to be able to solubilise or extract low-water solubility compounds. A few methods involving the use of solubilisers were described in the early 2000s. Since then, and particularly in

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2

Vaibhav, Gulabrao Bhamare, Ravindra Joshi Renuka, Sakharam Gangurde Mayur, and V. Pawar Vijay. "Theoretical consideration of solubility by Hildebrand solubility approach." World Journal of Advanced Research and Reviews 12, no. 3 (2021): 528–41. https://doi.org/10.5281/zenodo.5813923.

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Pharmaceutical field is widely focusing on solubility parameter models to select solvent or non-solvent that can enhance solvency of drug. Solubility Parameter is very useful concept in understanding the mechanism of solvent and solvency behavior with their applications in pharmaceuticals to open the door of research having focus on theoretical considerations of solubility. Hildebrand and Hansen Solubility Parameter are frequently used to identify solvents.

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3

Van Dyk, John W., Harry L. Frisch, and Dao T. Wu. "Solubility, solvency, and solubility parameters." Industrial & Engineering Chemistry Product Research and Development 24, no. 3 (1985): 473–78. http://dx.doi.org/10.1021/i300019a028.

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4

Aghnatios, C., R. Losno, and F. Dulac. "A fine fraction of soil used as an aerosol analogue during the DUNE experiment: sequential solubility in water, decreasing pH step-by-step." Biogeosciences 11, no. 17 (2014): 4627–33. http://dx.doi.org/10.5194/bg-11-4627-2014.

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Abstract. A soil sample collected in a desert aerosol source area near Douz (southern Tunisia) was dry-sieved at 20 μm in order to extract the fraction similar to a wind-generated aerosol, and was used to seed mesocosms during the DUNE experiment (a DUst experiment in a low Nutrient, low chlorophyll Ecosystem). In this work, said "aerosol-like" fine dust was sequentially leached by short contacts with water at initial pHs, decreasing from seven to one, representing various wet environmental conditions. For each step, the solubility of a given element is calculated as the amount of its dissolve

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5

O'Brien, Geoffrey G. "Solubility." Iowa Review 30, no. 3 (2000): 52–53. http://dx.doi.org/10.17077/0021-065x.5323.

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6

Azimullah, Stanekzai, ,. Vikrant, CK Sudhakar, et al. "Nanosuspensions as a promising approach to enhance bioavailability of poorly soluble drugs : An update." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 574–82. http://dx.doi.org/10.22270/jddt.v9i2.2436.

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Solubility is a vital factor for devloping drug delivery systems for poorly water soluble drugs. Several conventional approaches for enhancement of solubility have limited applicability, especially when the drugs are poorly water soluble. Nanosuspension technology can be used to enhance the solubilty, stability as well as the bioavailability of poorly water soluble drugs. Nanosuspensions are biphasic systems comperising of pure drug particles dispersed in an aqueous vehicle, stabilized by surfac active agents. Fabrication of nanosuspension is simple and more advantageous than other approaches.

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7

Benne, Darja, and Harald Behrens. "Water solubility in haplobasaltic melts." European Journal of Mineralogy 15, no. 5 (2003): 803–14. http://dx.doi.org/10.1127/0935-1221/2003/0015-0803.

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8

Bajait, Manoj Gajanan. "IMPORTANCE OF SOLUBILITY AND SOLUBILITY ENHANCEMENT TECHNIQUES." Journal of Medical Pharmaceutical And Allied Sciences 8, no. 6 (2019): 2403–16. http://dx.doi.org/10.22270/jmpas.v8i6.878.

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9

Carpenter, John H. "Solubility Products and Solubility: Plus Ca Change?" Journal of Chemical Education 66, no. 2 (1989): 184. http://dx.doi.org/10.1021/ed066p184.

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10

Redelius, Per. "Bitumen Solubility Model Using Hansen Solubility Parameter." Energy & Fuels 18, no. 4 (2004): 1087–92. http://dx.doi.org/10.1021/ef0400058.

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11

Tessiri, Chanikanda, Sunee Channarong, and Paveena Wongtrakul. "Development of Aqueous Formulation Containing the Extracted Mangiferin." Key Engineering Materials 901 (October 8, 2021): 40–47. http://dx.doi.org/10.4028/www.scientific.net/kem.901.40.

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Mangiferin, a polyphenol of C-glycosylxanthone, exhibits various bioactivities with poor aqueous solubility. It is known as a potent antioxidant, which leads to remarkable UV protection and anti-aging properties. Mangiferin can be found in many plant species, among which the mango leaf is one of the primary sources. From our study, the extraction yield of mangifein obtained from the leaves of Mangifera indica L. variety Nam Doc Mai was 3.17% with 95.02% ± 0.064 purity (HPTLC analysis). The solubility of mangiferin in the studied pure solvents arranging in descending order were ethoxydiglycol,

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12

Thorn, Andrew. "Safer Solubility." Studies in Conservation 37, no. 1 (1992): 12. http://dx.doi.org/10.2307/1506433.

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13

Thorn, Andrew. "Safer solubility." Studies in Conservation 37, no. 1 (1992): 12–21. http://dx.doi.org/10.1179/sic.1992.37.1.12.

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14

Vaibhav Gulabrao Bhamare, Renuka Ravindra Joshi, Mayur Sakharam Gangurde, and Vijay V Pawar. "Theoretical consideration of solubility by Hildebrand solubility approach." World Journal of Advanced Research and Reviews 12, no. 3 (2021): 528–41. http://dx.doi.org/10.30574/wjarr.2021.12.3.0680.

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Pharmaceutical field is widely focusing on solubility parameter models to select solvent or non-solvent that can enhance solvency of drug. Solubility Parameter is very useful concept in understanding the mechanism of solvent and solvency behavior with their applications in pharmaceuticals to open the door of research having focus on theoretical considerations of solubility. Hildebrand and Hansen Solubility Parameter are frequently used to identify solvents.

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15

Ibrahim, Naz, Shahla Smail, Nozad Hussein, and Tara Abdullah. "Solubility enhancement of nimodipine using mixed hydrotropic solid dispersion technique." Zanco Journal of Medical Sciences 24, no. 3 (2020): 386–94. http://dx.doi.org/10.15218/zjms.2020.046.

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Background and objective: Low aqueous solubility of active pharmaceutical ingredients has an effect on both formulation development and bioavailability. Nimodipine is an antihypertensive agent with low oral bioavailability, which might be attributed to the extremely poor water solubility. This study aimed to increase the solubility of nimodipine in water using hydrotropes and solid dispersion technology to increase dissolution rate compared to the marketed drug product. Methods: Solubility of nimodipine was determined separately in sodium acetate, sodium citrate, sodium benzoate, and niacinami

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16

Anjali, Motwani* Pooja Hatwar Dr. Ravindra Bakal. "Advances in Solubility Enhancement of Poorly Soluble Drugs in Pharmaceutical Development: A Review of Current Techniques and Strategies." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 138–48. https://doi.org/10.5281/zenodo.14029216.

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Solubility is a key determinant in the bioavailability of drugs, particularly those categorized under Class II and IV of the Biopharmaceutical Classification System (BCS), which exhibit poor aqueous solubility. This review provides an introduction to the concept of solubility, alongside a brief discussion on the BCS classification. Key definitions of solubility are presented, followed by a mention of several factors affecting solubility, such as temperature, pH, and particle size. The article then outlines various techniques employed to enhance solubility, including physical methods like parti

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17

Arianie, Lucy. "Potention of Lignin, Lignin Sulfonate and Lignin Acetate from Palm Empty Bunch as an Additive Substance in Urea Fertilizer as an Effort to Reduce the Solubility of Urea Nitrogen." Advanced Materials Research 93-94 (January 2010): 409–12. http://dx.doi.org/10.4028/www.scientific.net/amr.93-94.409.

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Hydrophobic lignin’s character is used as the base of lignin usage as the binder in the urea fertilizer tablet. Lignin was isolated from black liquor of pulp and paper with palm empty bunch materials. Sulfonation of lignin isolate produced lignin sulfonate. Acetylation of lignin isolate produced lignin acetate. Lignin, lignin sulfonate and lignin acetate analyzed its solubility showed that lignin has no solubility in water. Therefore, urea fertilizer need to be modified by lignin. Nitrogen concentration of tablet lignin – urea with variation of lignin percentage 1,2,3,4 and 5 % examined with K

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18

Pigeon, Pascal, Feten Najlaoui, Michael James McGlinchey, Juan Sanz García, Gérard Jaouen, and Stéphane Gibaud. "Unravelling the Role of Uncommon Hydrogen Bonds in Cyclodextrin Ferrociphenol Supramolecular Complexes: A Computational Modelling and Experimental Study." International Journal of Molecular Sciences 24, no. 15 (2023): 12288. http://dx.doi.org/10.3390/ijms241512288.

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We sought to determine the cyclodextrins (CDs) best suited to solubilize a patented succinimido-ferrocidiphenol (SuccFerr), a compound from the ferrociphenol family having powerful anticancer activity but low water solubility. Phase solubility experiments and computational modelling were carried out on various CDs. For the latter, several CD-SuccFerr complexes were built starting from combinations of one or two CD(s) where the methylation of CD oxygen atoms was systematically changed to end up with a database of ca. 13 k models. Modelling and phase solubility experiments seem to indicate the p

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19

Nainwal, Nidhi, Ranjit Singh, Sunil Jawla, and Vikas Anand Saharan. "The Solubility-Permeability Interplay for Solubility-Enabling Oral Formulations." Current Drug Targets 20, no. 14 (2019): 1434–46. http://dx.doi.org/10.2174/1389450120666190717114521.

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The Biopharmaceutical classification system (BCS) classifies the drugs based on their intrinsic solubility and intestinal permeability. The drugs with good solubility and intestinal permeability have good bioavailability. The drugs with poor solubility and poor permeability have solubility dependent and permeability dependent bioavailability, respectively. In the current pharmaceutical field, most of the drugs have poor solubility. To solve the problem of poor solubility, various solubility enhancement approaches have been successfully used. The effects of these solubility enhancing approaches

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20

Hewitt, M., M. T. D. Cronin, S. J. Enoch, J. C. Madden, D. W. Roberts, and J. C. Dearden. "In Silico Prediction of Aqueous Solubility: The Solubility Challenge." Journal of Chemical Information and Modeling 49, no. 11 (2009): 2572–87. http://dx.doi.org/10.1021/ci900286s.

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21

Lou, Yuecun, Pingjiao Hao, and Glenn Lipscomb. "NELF predictions of a solubility–solubility selectivity upper bound." Journal of Membrane Science 455 (April 2014): 247–53. http://dx.doi.org/10.1016/j.memsci.2013.12.071.

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22

Saal, Christoph, and Anna Christine Petereit. "Optimizing solubility: Kinetic versus thermodynamic solubility temptations and risks." European Journal of Pharmaceutical Sciences 47, no. 3 (2012): 589–95. http://dx.doi.org/10.1016/j.ejps.2012.07.019.

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23

Buchowski, H., and A. Khiat. "Solubility of solids in liquids: one-parameter solubility equation." Fluid Phase Equilibria 25, no. 3 (1986): 273–78. http://dx.doi.org/10.1016/0378-3812(86)80003-6.

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24

Pinal, Rodolfo, and Samuel H. Yalkowsky. "Solubility and Partitioning VII: Solubility of Barbiturates in Water." Journal of Pharmaceutical Sciences 76, no. 1 (1987): 75–85. http://dx.doi.org/10.1002/jps.2600760120.

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25

Pinal, Rodolfo, and Samuel H. Yalkowsky. "Solubility and Partitioning IX: Solubility of Hydantoins in Water." Journal of Pharmaceutical Sciences 77, no. 6 (1988): 518–22. http://dx.doi.org/10.1002/jps.2600770611.

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26

Mattigod, Shas V., Dhanpat Rai, Andrew R. Felmy, and Linfeng Rao. "Solubility and solubility product of crystalline Ni(OH)2." Journal of Solution Chemistry 26, no. 4 (1997): 391–403. http://dx.doi.org/10.1007/bf02767678.

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27

Vishakha, Vishwanath Doke, M. Khutle Nilesh, Sharma Maya, and Gupta Khemchand. "Self-Solidifying and Self-Nanoemulsifying Drug Delivery System of Itraconazole." Indian Journal of Science and Technology 16, no. 3 (2023): 190–203. https://doi.org/10.17485/IJST/v16i3.1940.

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ABSTRACT <strong>Objective:</strong> To improve solubility, dissolution, and permeability of BCS class II drug Itraconazole (ITZ) using a self solidifying self nano emulsifying drug delivery system (SNEDDS). <strong>Method:</strong> The solubility of ITZ was assessed in oils, surfactants, co-surfactants, and buffers. Surfactants, co-surfactants, and combination of surfactants (S-comb) were selected on the basis of emulsification efficacy test. The ability to solidify self emulsifying mixture was assessed and solid SNEDDSS was developed and optimised. <strong>Finding:</stron

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28

Kaur, Gurleen, Alfisha Saifi, Kapil Kumar, and Deepak Teotia. "Development and Evaluation of Micro Emulsion Formulations of Nebivolol for Solubility Enhancement." Journal of Drug Delivery and Therapeutics 11, no. 5 (2021): 84–89. http://dx.doi.org/10.22270/jddt.v11i5.5005.

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Nebivolol HCl is a newer drug of β1-adrenergic blocker category, basically used as anti-hypertensive. It is a 3rd generation, antagonist, having NO (nitric oxide) enhancing vasodilator properties. It has 12% oral bioavailability, because of its pre systemic metabolism by the means of cytochrome P450 2D6 enzymes. Its log P value is 4.03 and 5mg is its daily dose. It is highly lipophilic drug and belongs to class BCS II, with slow dissolution. Bioavailability of any drug can be improved by avoiding its first pass metabolism and promoting solubility. Several researchers have worked on the develop

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29

Asim Mushtaq, Asim Mushtaq, and Hilmi Mukhtar and Azmi Mohd Shariff Hilmi Mukhtar and Azmi Mohd Shariff. "Solubility Parameter Study of Polysulfone, Polyvinyl Acetate in Dimethylacetamide Solvent." Journal of the chemical society of pakistan 41, no. 1 (2019): 203. http://dx.doi.org/10.52568/000726/jcsp/41.01.2019.

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The solubility parameter is calculated to express the magnitude and nature of the interactive forces between the polymers and solvents. It measures the affinity between the components of a mixture. To improve the prediction of the solubility parameter, the group contribution method is used to calculate the overall solubility parameter as suggested by Hildebrand. Hildebrand’s method is used to predict the interaction between the polymers and solvent. In this study, calculate the solubility parameters of polysulfone (PSU), polyvinyl acetate (PVAc) polymers and dimethylacetamide (DMAc) solvent by

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30

Hasanova, Z. T. "SOLUBILITY OF GERMANIUM DISELENIDE IN THE Cu3AsSe4." Azerbaijan Chemical Journal, no. 4 (December 8, 2021): 67–70. http://dx.doi.org/10.32737/0005-2531-2021-4-67-70.

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Differential thermal analysis and powder X-ray diffraction methods were used for phase equilibria studying in the Cu3AsSe4-GeSe2 system. It was established that wide (up to 30 mol.%) solid solutions based on Cu3AsSe4 are formed. GeSe2-rich alloys consist of various heterogeneous mixtures, including phases outside the T–x plane of this section

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31

Dutchak, Vasyl, Olena Astakhova, and Leonid Kvitkovsky. "Reciprocal Solubility of Gasoline Fractions and Ethanol." Chemistry & Chemical Technology 5, no. 2 (2011): 215–20. http://dx.doi.org/10.23939/chcht05.02.215.

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32

Ahirrao, Sapana P., Kishor S. Rathi, Diksha B. Koli, Sanjay J. Kshirsagar, and Sarita Pawar. "SOLUBILITY ENHANCEMENT OF NITAZOXANIDE USING SOLID DISPERSION." Indian Research Journal of Pharmacy and Science 5, no. 4 (2018): 1674–87. http://dx.doi.org/10.21276/irjps.2018.5.4.6.

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33

Teerapipattanapong, Panida, Pimrada Jaikon, Nichapa Ningsanonda, et al. "Evaluating Various Lactose Types as Solid Carriers for Improving Curcumin Solubility in Solid Self-Nanoemulsifying Drug Delivery Systems (S-SNEDDSs) for Oral Administration." Sci 6, no. 4 (2024): 69. http://dx.doi.org/10.3390/sci6040069.

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Curcumin, a bioactive compound derived from turmeric, possesses numerous pharmaceutical properties; however, its poor aqueous solubility and permeability result in low bioavailability. This study aims to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) using different lactose types as solid carriers for the oral administration of curcumin to enhance its solubility. The system comprised curcumin, an oil phase, and a surfactant. Jasmine oil, as the oil phase, and Cremophor® RH40, as the surfactant, were selected due to their superior ability to solubilize curcumin. A microemu

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34

Singh, Narinder, Amar Pal Singh, and Ajeet Pal Singh. "Solubility: An overview." International Journal of Pharmaceutical Chemistry and Analysis 7, no. 4 (2021): 166–71. http://dx.doi.org/10.18231/j.ijpca.2020.027.

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35

Mamardashvili, Galina, Nugdzar Mamardashvili, and Boris Berezin. "Solubility of Alkylporphyrins." Molecules 5, no. 12 (2000): 762–66. http://dx.doi.org/10.3390/50600762.

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36

Marcus, Yizhak, Allan L. Smith, M. V. Korobov, A. L. Mirakyan, N. V. Avramenko, and E. B. Stukalin. "Solubility of C60Fullerene." Journal of Physical Chemistry B 105, no. 13 (2001): 2499–506. http://dx.doi.org/10.1021/jp0023720.

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37

Eger, EI. "ANESTHETIC PLASTIC SOLUBILITY." Anesthesiology 69, no. 3A (1988): A297. http://dx.doi.org/10.1097/00000542-198809010-00296.

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38

Kachalina, О. V., and A. A. Korenkova. "Cervical endometriosis – solubility." Medical Council, no. 21 (January 20, 2019): 174–77. http://dx.doi.org/10.21518/2079-701x-2018-21-174-177.

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Cervical endometriosis is a common disease in young women, which is characterized by the appearance of tissue on the vaginal part of the cervix, similar in structure to the endometrium and undergoing cyclic changes in accordance with the menstrual cycle, and is a form of external genital endometriosis. The article presents the pathogenetic mechanisms of this disease development in terms of possibility of exposure to them during pathogenetic therapy.

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39

Sinclair, Meeghan. "Monitoring protein solubility." Nature Biotechnology 19, no. 2 (2001): 101. http://dx.doi.org/10.1038/84325.

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40

Marshall, Andrew. "Photoreversible enzyme solubility." Nature Biotechnology 17, no. 1 (1999): 10. http://dx.doi.org/10.1038/5356.

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41

Clever, H. Lawrence. "Solubility of mercury." Journal of Chemical Education 62, no. 8 (1985): 720. http://dx.doi.org/10.1021/ed062p720.2.

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42

Gildea, Brian D., Shelagh Casey, Joan MacNeill, Heather Perry-O'Keefe, Ditte Sørensen, and James M. Coull. "PNA solubility enhancers." Tetrahedron Letters 39, no. 40 (1998): 7255–58. http://dx.doi.org/10.1016/s0040-4039(98)01581-0.

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43

Wolf, B. A. "Solubility of polymers." Pure and Applied Chemistry 57, no. 2 (1985): 323–36. http://dx.doi.org/10.1351/pac198557020323.

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44

Ewing, F., E. Forsythe, and M. Pusey. "Orthorhombic lysozyme solubility." Acta Crystallographica Section D Biological Crystallography 50, no. 4 (1994): 424–28. http://dx.doi.org/10.1107/s0907444993014428.

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45

Darrow, Frank W. "Solubility (Hallgren, Richard)." Journal of Chemical Education 66, no. 1 (1989): A43. http://dx.doi.org/10.1021/ed066pa43.

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46

Corkern, Walter H., and Linda L. Munchausen. "Solubility of alcohols." Journal of Chemical Education 69, no. 11 (1992): 928. http://dx.doi.org/10.1021/ed069p928.1.

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47

Avdeef, Alex, and Cynthia M. Berger. "pH-metric solubility." European Journal of Pharmaceutical Sciences 14, no. 4 (2001): 281–91. http://dx.doi.org/10.1016/s0928-0987(01)00190-7.

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48

Rizzi, L. G., and S. Auer. "Amyloid Fibril Solubility." Journal of Physical Chemistry B 119, no. 46 (2015): 14631–36. http://dx.doi.org/10.1021/acs.jpcb.5b09210.

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49

Butina, Darko, and Joelle M. R. Gola. "Modeling Aqueous Solubility." Journal of Chemical Information and Computer Sciences 43, no. 3 (2003): 837–41. http://dx.doi.org/10.1021/ci020279y.

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50

Asherie, Neer, Charles Ginsberg, Samuel Blass, Arieh Greenbaum, and Sarah Knafo. "Solubility of Thaumatin." Crystal Growth & Design 8, no. 6 (2008): 1815–17. http://dx.doi.org/10.1021/cg800276r.

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