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Journal articles on the topic 'Soluble CD89'

Author: Grafiati

Published: 22 June 2024

Last updated: 31 July 2025

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1

Launay, Pierre, Béatrice Grossetête, Michelle Arcos-Fajardo та ін. "Fcα Receptor (Cd89) Mediates the Development of Immunoglobulin a (Iga) Nephropathy (Berger's Disease)". Journal of Experimental Medicine 191, № 11 (1999): 1999–2010. http://dx.doi.org/10.1084/jem.191.11.1999.

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The pathogenesis of immunoglobulin A (IgA) nephropathy (IgAN), the most prevalent form of glomerulonephritis worldwide, involves circulating macromolecular IgA1 complexes. However, the molecular mechanism(s) of the disease remain poorly understood. We report here the presence of circulating soluble FcαR (CD89)-IgA complexes in patients with IgAN. Soluble CD89 was identified as a glycoprotein with a 24-kD backbone that corresponds to the expected size of CD89 extracellular domains. To demonstrate their pathogenic role, we generated transgenic (Tg) mice expressing human CD89 on macrophage/monocy

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2

van Zandbergen, Ger, Ralf Westerhuis, Ngaisah Klar Mohamad, Jan G. J. van de Winkel, Mohamed R. Daha та Cees van Kooten. "Crosslinking of the Human Fc Receptor for IgA (FcαRI/CD89) Triggers FcR γ-Chain-Dependent Shedding of Soluble CD89". Journal of Immunology 163, № 11 (1999): 5806–12. http://dx.doi.org/10.4049/jimmunol.163.11.5806.

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Abstract CD89/FcαRI is a 55- to 75-kDa type I receptor glycoprotein, expressed on myeloid cells, with important immune effector functions. At present, no information is available on the existence of soluble forms of this receptor. We developed an ELISA for the detection of soluble CD89 (sCD89) forms and investigated the regulation of sCD89 production. PMA/ionomycin stimulation of monocytic cell lines (U937, THP-1, and MM6), but not of neutrophils, resulted in release of sCD89. Crosslinking of CD89 either via its ligand IgA or with anti-CD89 mAbs similarly resulted in sCD89 release. Using CD89-

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3

Esteve Cols, Clara, Freddzia-Amanda Graterol Torres, Bibiana Quirant Sánchez, et al. "Immunological Pattern in IgA Nephropathy." International Journal of Molecular Sciences 21, no. 4 (2020): 1389. http://dx.doi.org/10.3390/ijms21041389.

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The current gold-standard diagnostic technique for IgA nephropathy (IgAN), the leading form of primary glomerulonephritis, is renal biopsy. CD89 (the main IgA receptor) is expressed on the surface of monocytes and plays a role in disease pathogenesis. Immunocomplexes formed by sCD89 (soluble form) and Gd-IgA1 are related to disease prognosis. We hypothesize that reduced CD89 surface expression on monocytes may be a marker of disease severity. We aimed to analyze leukocyte subpopulations in peripheral blood and CD89 surface expression on monocytes in a prospective study of 22 patients and 12 he

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4

Wu, Haiting, Xiaoyan Wang, Zhe Yang, et al. "Serum Soluble CD89-IgA Complexes Are Elevated in IgA Nephropathy without Immunosuppressant History." Disease Markers 2020 (January 16, 2020): 1–6. http://dx.doi.org/10.1155/2020/8393075.

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Purpose. CD89 (FcαRI), the receptor of IgA, can shed from cells to form complexes with IgA in serum and is supposed to participate in the pathogenesis of IgA nephropathy (IgAN). There are contradictory results on their utility in clinical practice. This study is aimed at investigating whether sCD89-IgA complexes can help in the diagnosis or evaluation of the disease. Methods. A sandwich ELISA was established using anti-CD89 as a capture antibody and HRP-conjugated anti-IgA as a detection antibody. This method was used to measure serum levels of sCD89-IgA complexes in IgAN patients without immu

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5

Cambier, Alexandra, Patrick J. Gleeson, Lilia Abbad, et al. "Soluble CD89 is a critical factor for mesangial proliferation in childhood IgA nephropathy." Kidney International 101, no. 2 (2022): 274–87. http://dx.doi.org/10.1016/j.kint.2021.09.023.

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6

Berthelot, Laureline, Thomas Robert, Vincent Vuiblet, et al. "Recurrent IgA nephropathy is predicted by altered glycosylated IgA, autoantibodies and soluble CD89 complexes." Kidney International 88, no. 4 (2015): 815–22. http://dx.doi.org/10.1038/ki.2015.158.

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7

Vuong, Mai T., Mirjana Hahn-Zoric, Sigrid Lundberg, et al. "Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy." Kidney International 78, no. 12 (2010): 1281–87. http://dx.doi.org/10.1038/ki.2010.314.

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8

Hahn-Zoric, Mirjana, Mai Vuong, Sigrid Lundberg, et al. "Su.82. Evidence for Genetic Regulation of Fc Alpha Receptor (CD89) Expression: Study of Soluble CD89 in Plasma of IgA Nephropathy Patients and Healthy Controls." Clinical Immunology 127 (January 2008): S151. http://dx.doi.org/10.1016/j.clim.2008.03.433.

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9

Hahn-Zoric, Mirjana, Neda Tahmasebifar, Cees van Kooten, et al. "Immunoassays for Detection of Soluble Fc Alpha Receptor (CD89) in Plasma of IgA Nephropathy Patients." Clinical Immunology 123 (2007): S54—S55. http://dx.doi.org/10.1016/j.clim.2007.03.335.

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10

Berthelot, Laureline, Christina Papista, Thiago T. Maciel, et al. "Transglutaminase is essential for IgA nephropathy development acting through IgA receptors." Journal of Experimental Medicine 209, no. 4 (2012): 793–806. http://dx.doi.org/10.1084/jem.20112005.

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IgA nephropathy (IgAN) is a common cause of renal failure worldwide. Treatment is limited because of a complex pathogenesis, including unknown factors favoring IgA1 deposition in the glomerular mesangium. IgA receptor abnormalities are implicated, including circulating IgA–soluble CD89 (sCD89) complexes and overexpression of the mesangial IgA1 receptor, TfR1 (transferrin receptor 1). Herein, we show that although mice expressing both human IgA1 and CD89 displayed circulating and mesangial deposits of IgA1–sCD89 complexes resulting in kidney inflammation, hematuria, and proteinuria, mice expres

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11

Nockher, W. A., and J. E. Scherberich. "Expression and release of the monocyte lipopolysaccharide receptor antigen CD14 are suppressed by glucocorticoids in vivo and in vitro." Journal of Immunology 158, no. 3 (1997): 1345–52. http://dx.doi.org/10.4049/jimmunol.158.3.1345.

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Abstract The effect of glucocorticoid (GC) treatment on expression and release of the monocyte cell surface LPS receptor Ag CD14 was studied in vivo and in vitro. In patients with acute inflammatory diseases receiving GC pulse therapy serum concentrations of soluble CD14 and CD14 expression by peripheral blood monocytes decreased significantly. The LPS-binding capacity correlated positively with the amount of cell surface CD14 by human blood monocytes. In vitro, a time- and dose-dependent effect of GC preparations on monocyte membrane and soluble CD14 by cultured peripheral blood monocytes was

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Berthelot, L., P. Housset, V. Sauvaget, A. Jamin, R. C. Monteiro, and E. Pillebout. "Complexes IgA-CD89 soluble comme biomarqueurs d’atteinte rénale et facteur de risque de progression au cours du purpura rhumatoïde." Néphrologie & Thérapeutique 9, no. 5 (2013): 278. http://dx.doi.org/10.1016/j.nephro.2013.07.184.

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13

Tissandié, Emilie, Willy Morelle, Laureline Berthelot, et al. "Both IgA nephropathy and alcoholic cirrhosis feature abnormally glycosylated IgA1 and soluble CD89–IgA and IgG–IgA complexes: common mechanisms for distinct diseases." Kidney International 80, no. 12 (2011): 1352–63. http://dx.doi.org/10.1038/ki.2011.276.

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14

Yu, Shufeng, Ranran Zhang, Yi Lin, Ke Lei, Juan Zhang, and Hong Chang. "Blood soluble CD89-IgA complex may be a potential biomarker for predicting multi-organ involvement, especially renal involvement in children with immunoglobulin A vasculitis." International Immunopharmacology 142 (December 2024): 113063. http://dx.doi.org/10.1016/j.intimp.2024.113063.

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15

Monteiro, Renato C., Dina Rafeh, and Patrick J. Gleeson. "Is There a Role for Gut Microbiome Dysbiosis in IgA Nephropathy?" Microorganisms 10, no. 4 (2022): 683. http://dx.doi.org/10.3390/microorganisms10040683.

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Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis and one of the leading causes of renal failure worldwide. The pathophysiology of IgAN involves nephrotoxic IgA1-immune complexes. These complexes are formed by galactose-deficient (Gd) IgA1 with autoantibodies against the hinge region of Gd-IgA1 as well as soluble CD89, an immune complex amplifier with an affinity for mesangial cells. These multiple molecular interactions result in the induction of the mesangial IgA receptor, CD71, injuring the kidney and causing disease. This review features recent immunological

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16

Lal, R. B., D. L. Rudolph, C. S. Dezzutti, P. S. Linsley, and H. E. Prince. "Costimulatory effects of T cell proliferation during infection with human T lymphotropic virus types I and II are mediated through CD80 and CD86 ligands." Journal of Immunology 157, no. 3 (1996): 1288–96. http://dx.doi.org/10.4049/jimmunol.157.3.1288.

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Abstract The modulation of expression of CD80 and CD86 on T cells following infection with human T lymphotropic virus (HTLV)-I/II and its functional importance in T-T cell interactions was examined. Infection with HTLV-I/II leads to constitutive expression of CD80 and CD86, concomitant to down-modulation of CD28 on T cells. The CD80/CD86+ HTLV-infected T cells stimulated proliferation of allogeneic and autologous resting T cells, which could be specifically blocked by a soluble CTLA-4Ig chimeric protein, anti-CD80 or anti-CD86, but not by anti-CD54. It was necessary to inhibit interaction with

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17

Chai, Jian-Guo, Silvia Vendetti, Istvan Bartok, et al. "Critical Role of Costimulation in the Activation of Naive Antigen-Specific TCR Transgenic CD8+ T Cells In Vitro." Journal of Immunology 163, no. 3 (1999): 1298–305. http://dx.doi.org/10.4049/jimmunol.163.3.1298.

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Abstract The influence of costimulation on the activation of naive CD8+ T cells and thymocytes was studied in vitro using H-Y-specific TCR-transgenic mice and H-Y antigenic peptide. Using a variety of physiological APC types, the activation of naive CD8+ T cells depended strictly on costimulation, which could not be substituted by high epitope density. T cell activation is known to be regulated by the interactions between CD86/CD80 and CD28/CD152, although it remains unclear whether the B7 isoforms have distinct roles. Addition of soluble anti-CD86 Ab led to profound inhibition of T cell react

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18

Motta, Juliana, Morgana Castelo-Branco, and Vivian Rumjanek. "Characterization of human monocyte-derived dendritic cells in the presence of leukemic cell soluble products (127.14)." Journal of Immunology 188, no. 1_Supplement (2012): 127.14. http://dx.doi.org/10.4049/jimmunol.188.supp.127.14.

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Abstract Professional antigen-presenting cells, dendritic cells (DCs) play an important role in controlling tumors, since they are able to initiate an antitumoral immune response. Some works demonstrate that products secreted by solid tumor cells can modulate DCs, however, leukemic cell products are not well studied. Considering that leukemic cells are present in the same place as monocytes (DCs precursor), we analyzed a possible influence of leukemic cell products on DC development and function. For this, monocytes from healthy donors were separated by density gradient and cultured, for 5 day

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19

Chai, Jian-Guo, Istvan Bartok, Diane Scott, Julian Dyson, and Robert Lechler. "T:T Antigen Presentation by Activated Murine CD8+ T Cells Induces Anergy and Apoptosis." Journal of Immunology 160, no. 8 (1998): 3655–65. http://dx.doi.org/10.4049/jimmunol.160.8.3655.

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Abstract Using an IL-2-secreting, noncytolytic, H-Y-specific, CD8+ T cell clone, the functional consequences of Ag presentation by T cells to T cells were investigated. Incubation of the T cells with H-Y-soluble peptide led to nonresponsiveness to Ag rechallenge. This was due to the simultaneous induction of apoptosis, involving approximately 40% of the T cells, and of anergy in the surviving cells. These effects were strictly dependent upon bidirectional T:T presentation, in that exposure of C6 cells to peptide-pulsed T cells from the same clone induced proliferation but not apoptosis or aner

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20

Chung, Yeonseok, Jae-Hoon Chang, Mi-Na Kweon, Paul D. Rennert та Chang-Yuil Kang. "CD8α–11b+ dendritic cells but not CD8α+ dendritic cells mediate cross-tolerance toward intestinal antigens". Blood 106, № 1 (2005): 201–6. http://dx.doi.org/10.1182/blood-2004-11-4240.

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Cross-presentation is a critical process by which antigen is displayed to CD8 T cells to induce tolerance. It is believed that CD8α+ dendritic cells (DCs) are responsible for cross-presentation, suggesting that the CD8α+ DC population is capable of inducing both cross-priming and cross-tolerance to antigen. We found that cross-tolerance against intestinal soluble antigen was abrogated in C57BL/6 mice lacking mesenteric lymph nodes (MLNs) and Peyer patches (PPs), whereas mice lacking PPs alone were capable of developing CD8 T-cell tolerance. CD8α–CD11b+ DCs but not CD8α+ DCs in the MLNs present

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21

Feldmeier, Ferdinand, Manuel Weber, Franca Pacelli, et al. "Investigation of the CTLA-4–CD28 Axis in Oral Squamous Cell Carcinoma." Journal of Clinical Medicine 14, no. 14 (2025): 5171. https://doi.org/10.3390/jcm14145171.

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Background: Oral squamous cell carcinoma (OSCC) is a common head and neck cancer with low survival rates, especially in advanced stages, despite improved therapies. New developments show that immune checkpoint inhibitors (ICIs) are promising treatment options. A better understanding of immune suppression in OSCC could enable new therapeutic approaches and effective ICI combinations. Methods: The aim of this cross-sectional study was to investigate the significance of the differential expression of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), CD28 and their ligands CD80 and CD86 for th

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22

Hock, B. D., J. L. O'Donnell, K. Taylor, et al. "Levels of the soluble forms of CD80, CD86, and CD83 are elevated in the synovial fluid of rheumatoid arthritis patients." Tissue Antigens 67, no. 1 (2006): 57–60. http://dx.doi.org/10.1111/j.1399-0039.2005.00524.x.

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23

Morva, Ahsen, Sébastien Lemoine, Achouak Achour, Jacques-Olivier Pers, Pierre Youinou, and Christophe Jamin. "Maturation and function of human dendritic cells are regulated by B lymphocytes." Blood 119, no. 1 (2012): 106–14. http://dx.doi.org/10.1182/blood-2011-06-360768.

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Abstract Mature dendritic cells (DCs) are stimulators of T-cell immune response, whereas immature DCs support T-cell tolerance. Murine B cells can inhibit the production of IL-12 by DCs and thereby hinder the inflammatory response. Notwithstanding the importance of this modulation, only a few studies are available in humans. Here, we have developed an in vitro model of cocultures to assess its significance. We establish that human activated B cells restrained the development of monocytes into immature DCs and their differentiation into mature DCs. In addition, they decreased the density of HLA

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24

Li, Haiyan, Sungyoul Hong, Jianfei Qian, Yuhuan Zheng, Jing Yang, and Qing Yi. "Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells." Blood 116, no. 2 (2010): 210–17. http://dx.doi.org/10.1182/blood-2009-11-255026.

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Abstract The bone and immune systems are closely related through cellular and molecular interactions. Because bone-resorbing osteoclasts (OCs) are derived from the monocyte/macrophage lineage, similar to dendritic cells (DCs), we hypothesized that OCs could serve as antigen-presenting cells (APCs) to activate T cells. In this study, OCs were generated from human monocytes with stimulation by receptor activator of nuclear factor κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF). Results showed that, similar to DCs, OCs express major histocompatibility complex (MHC) classes I an

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25

Oehler, Leopold, Otto Majdic, Winfried F. Pickl, et al. "Neutrophil Granulocyte–committed Cells Can Be Driven to Acquire Dendritic Cell Characteristics." Journal of Experimental Medicine 187, no. 7 (1998): 1019–28. http://dx.doi.org/10.1084/jem.187.7.1019.

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Polymorphonuclear granulocytes (PMNs) are thought to fulfill their role in host defense primarily via phagocytosis and release of cytotoxic compounds and to be inefficient in antigen presentation and stimulation of specific T cells. Dendritic cells (DCs), in contrast, are potent antigen-presenting cells with the unique capacity to initiate primary immune responses. We demonstrate here that highly purified lactoferrin-positive immediate precursors of end-stage neutrophilic PMN (PMNp) can be reverted in their functional maturation program and driven to acquire characteristic DC features. Upon cu

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26

Tekguc, Murat, James Badger Wing, Motonao Osaki, Jia Long, and Shimon Sakaguchi. "Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells." Proceedings of the National Academy of Sciences 118, no. 30 (2021): e2023739118. http://dx.doi.org/10.1073/pnas.2023739118.

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Foxp3-expressing CD4+CD25+ regulatory T cells (Tregs) constitutively and highly express the immune checkpoint receptor cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), whose Treg-specific deficiency causes severe systemic autoimmunity. As a key mechanism of Treg-mediated suppression, Treg-expressed CTLA-4 down-regulates the expression of CD80/CD86 costimulatory molecules on antigen-presenting cells (APCs). Here, we show that Treg-expressed CTLA-4 facilitated Treg-APC conjugation and immune synapse formation. The immune synapses thus formed provided a stable platform whereby Tregs were abl

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Arcaro, Alexandre, Claude Grégoire, Talitha R. Bakker та ін. "CD8β Endows CD8 with Efficient Coreceptor Function by Coupling T Cell Receptor/CD3 to Raft-associated CD8/p56lck Complexes". Journal of Experimental Medicine 194, № 10 (2001): 1485–95. http://dx.doi.org/10.1084/jem.194.10.1485.

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The extraordinary sensitivity of CD8+ T cells to recognize antigen impinges to a large extent on the coreceptor CD8. While several studies have shown that the CD8β chain endows CD8 with efficient coreceptor function, the molecular basis for this is enigmatic. Here we report that cell-associated CD8αβ, but not CD8αα or soluble CD8αβ, substantially increases the avidity of T cell receptor (TCR)-ligand binding. To elucidate how the cytoplasmic and transmembrane portions of CD8β endow CD8 with efficient coreceptor function, we examined T1.4 T cell hybridomas transfected with various CD8β construct

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28

Tsuji, Shoutaro, Misako Matsumoto, Osamu Takeuchi, et al. "Maturation of Human Dendritic Cells by Cell Wall Skeleton of Mycobacterium bovis Bacillus Calmette-Guérin: Involvement of Toll-Like Receptors." Infection and Immunity 68, no. 12 (2000): 6883–90. http://dx.doi.org/10.1128/iai.68.12.6883-6890.2000.

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ABSTRACT The constituents of mycobacteria are an effective immune adjuvant, as observed with complete Freund's adjuvant. In this study, we demonstrated that the cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin (BCG-CWS), a purified noninfectious material consisting of peptidoglycan, arabinogalactan, and mycolic acids, induces maturation of human dendritic cells (DC). Surface expression of CD40, CD80, CD83, and CD86 was increased by BCG-CWS on human immature DC, and the effect was similar to those of interleukin-1β (IL-1β), tumor necrosis factor alpha (TNF-α), heat-killed BCG

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29

Lechmann, Matthias, Daniëlle J. E. B. Krooshoop, Diana Dudziak, et al. "The Extracellular Domain of CD83 Inhibits Dendritic Cell–mediated T Cell Stimulation and Binds to a Ligand on Dendritic Cells." Journal of Experimental Medicine 194, no. 12 (2001): 1813–21. http://dx.doi.org/10.1084/jem.194.12.1813.

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CD83 is an immunoglobulin (Ig) superfamily member that is upregulated during the maturation of dendritic cells (DCs). It has been widely used as a marker for mature DCs, but its function is still unknown. To approach its potential functional role, we have expressed the extracellular Ig domain of human CD83 (hCD83ext) as a soluble protein. Using this tool we could show that immature as well as mature DCs bind to CD83. Since CD83 binds a ligand also expressed on immature DCs, which do not express CD83, indicates that binding is not a homophilic interaction. In addition we demonstrate that hCD83e

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30

Nauta, Alma J., Ellie Lurvink, Alwine B. Kruisselbrink, Roelof Willemze, and Willem E. Fibbe. "Mesenchymal Stem Cells Inhibit Generation and Function of Both Monocyte-Derived and CD34-Derived Dendritic Cells." Blood 106, no. 11 (2005): 593. http://dx.doi.org/10.1182/blood.v106.11.593.593.

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Abstract Mesenchymal stem cells (MSCs) have been demonstrated to exert profound immunosuppressive properties on T cell proliferation. However, their effect on the initiators of the immune response, the dendritic cells (DCs), are relatively unknown. In the present study, the effects of MSCs on the differentiation and function of both monocyte-derived DCs and CD34+-derived DCs were investigated. Monocytes (CD1a-CD14+) were obtained from PB and were cultured with IL-4 and GM-CSF to induce differentiation into CD14-CD1a+ immature DCs. CD34+ hematopoietic progenitor cells were isolated from umbilic

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Corinti, Silvia, Donata Medaglini, Andrea Cavani, et al. "Human Dendritic Cells Very Efficiently Present a Heterologous Antigen Expressed on the Surface of Recombinant Gram-Positive Bacteria to CD4+ T Lymphocytes." Journal of Immunology 163, no. 6 (1999): 3029–36. http://dx.doi.org/10.4049/jimmunol.163.6.3029.

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Abstract Recombinant Streptococcus gordonii expressing on the surface the C-fragment of tetanus toxin was tested as an Ag delivery system for human monocyte-derived dendritic cells (DCs). DCs incubated with recombinant S. gordonii were much more efficient than DCs pulsed with soluble C-fragment of tetanus toxin at stimulating specific CD4+ T cells as determined by cell proliferation and IFN-γ release. Compared with DCs treated with soluble Ag, DCs fed with recombinant bacteria required 102- to 103-fold less Ag and were at least 102 times more effective on a per-cell basis for activating specif

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Faries, Mark B., Isabelle Bedrosian, Shuwen Xu, et al. "Calcium signaling inhibits interleukin-12 production and activates CD83+ dendritic cells that induce Th2 cell development." Blood 98, no. 8 (2001): 2489–97. http://dx.doi.org/10.1182/blood.v98.8.2489.

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Abstract Mature dendritic cells (DCs), in addition to providing costimulation, can define the Th1, in contrast to the Th2, nature of a T-cell response through the production of cytokines and chemokines. Because calcium signaling alone causes rapid DC maturation of both normal and transformed myeloid cells, it was evaluated whether calcium-mobilized DCs polarize T cells toward a Th1 or a Th2 phenotype. After human monocytes were cultured for 24 hours in serum-free medium and granulocyte-macrophage colony-stimulating factor to produce immature DCs, additional overnight culture with either calciu

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Andersson, Anders, Apostolos Bossios, Carina Malmhäll, et al. "Effects of tobacco smoke on IL-16 in CD8+ cells from human airways and blood: a key role for oxygen free radicals?" American Journal of Physiology-Lung Cellular and Molecular Physiology 300, no. 1 (2011): L43—L55. http://dx.doi.org/10.1152/ajplung.00387.2009.

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Chronic exposure to tobacco smoke leads to an increase in the frequency of infections and in the number of CD8+ and CD4+ cells as well as the CD4+ chemoattractant cytokine IL-16 in the airways. Here, we investigated whether tobacco smoke depletes intracellular IL-16 protein and inhibits de novo production of IL-16 in CD8+ cells from human airways and blood while increasing extracellular IL-16 and whether oxygen free radicals (OFR) are involved. Intracellular IL-16 protein in CD8+ cells and mRNA in all cells was decreased in bronchoalveolar lavage (BAL) samples from chronic smokers. This was al

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Zinser, Elisabeth, Matthias Lechmann, Antje Golka, Manfred B. Lutz, and Alexander Steinkasserer. "Prevention and Treatment of Experimental Autoimmune Encephalomyelitis by Soluble CD83." Journal of Experimental Medicine 200, no. 3 (2004): 345–51. http://dx.doi.org/10.1084/jem.20030973.

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CD83 is up-regulated on the surface of dendritic cells (DCs) during maturation and has been widely used as a marker for mature DCs. Recently, we reported the recombinant expression of the extracellular immunoglobulin domain of human CD83 (hCD83ext). Using this soluble form of CD83, allogeneic as well as specific cytotoxic T lymphocyte proliferation could be blocked in vitro. Here we report the functional analysis of soluble CD83 in vivo, using murine experimental autoimmune encephalomyelitis (EAE) as a model. Strikingly, only three injections of soluble CD83 prevented the paralysis associated

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Bowman, Christine E., Ada Chen, Damie Juat, et al. "Abstract 321: Inhibition of CD39 results in elevated ATP and activation of myeloid cells to promote anti-tumor immunity." Cancer Research 82, no. 12_Supplement (2022): 321. http://dx.doi.org/10.1158/1538-7445.am2022-321.

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Abstract CD39 (ENTPD1) is an ecto-nucleoside triphosphate diphosphohydrolase expressed widely in the tumor microenvironment (TME) responsible for catalyzing the conversion of ATP to AMP. Inhibition of CD39 enzymatic activity can promote anti-tumor immune responses by increasing the immunostimulatory substrate ATP and decreasing the formation of the product AMP, a precursor to immunoinhibitory adenosine. CD39 inhibition has been shown to have an anti-tumor effect by activating dendritic cells, macrophages, and NK cells in the TME to promote antigen presentation and inflammatory cytokine release

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Simone, Rita, Giampaola Pesce, Princey Antola, et al. "The Soluble Form of CTLA-4 from Serum of Patients with Autoimmune Diseases Regulates T-Cell Responses." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/215763.

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Cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is a costimulatory receptor transducing a potent inhibitory signal. Increasing evidence showed that CTLA-4 gene is an important susceptibility locus for autoimmune disorders. Alternatively spliced mRNA generates a soluble form, called sCTLA-4. Whereas low levels of sCTLA-4 are detected in normal human serum, increased/high serum levels are observed in several autoimmune diseases. The biological significance of increased sCTLA-4 serum level is not fully clarified yet. It can be envisaged that sCTLA-4 specifically inhibits the early T-cell act

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Tomita, Yuji, Eri Watanabe, Masumi Shimizu, Yasuyuki Negishi, Yukihiro Kondo, and Hidemi Takahashi. "Induction of tumor-specific CD8+ cytotoxic T lymphocytes from naïve human T cells by using Mycobacterium-derived mycolic acid and lipoarabinomannan-stimulated dendritic cells." Cancer Immunology, Immunotherapy 68, no. 10 (2019): 1605–19. http://dx.doi.org/10.1007/s00262-019-02396-8.

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Abstract The main effectors in tumor control are the class I MHC molecule-restricted CD8+ cytotoxic T lymphocytes (CTLs). Tumor-specific CTL induction can be regulated by dendritic cells (DCs) expressing both tumor-derived epitopes and co-stimulatory molecules. Immunosuppressive tolerogenic DCs, having down-regulated co-stimulatory molecules, are seen within the tumor mass and can suppress tumor-specific CTL induction. The tolerogenic DCs expressing down-regulated XCR1+CD141+ appear to be induced by tumor-derived soluble factors or dexamethasone, while the immunogenic DCs usually express XCR1+

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38

Prazma, Charlene M., and Thomas F. Tedder. "Ag-engaged B cells express CD83, a sensitive marker for B cell activation (83.15)." Journal of Immunology 178, no. 1_Supplement (2007): S114. http://dx.doi.org/10.4049/jimmunol.178.supp.83.15.

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Abstract CD83 is predominantly known as a surface marker that defines mature DCs. The generation of CD83−/− mice further demonstrates that thymic epithelial expression of CD83 plays a significant role in the efficient generation of CD4 single positive thymocytes. The altered phenotype and reduced number of peripheral CD4+ T cells in CD83−/− mice further suggests a role for CD83 in the peripheral lymphocyte function. With regards to the surface expression pattern of CD83, CD83 was detected in the thymic medullary compartment and was specifically detected on thymic DCs and B cells in the mouse.

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39

Butler, Marcus O., Osamu Imataki, Yoshihiro Yamashita, et al. "Human CD4+ T Cells Help CD8+ T Cells Proliferate Ex Vivo by Secreting Both IL-2/IL-21 and Upregulating IL-21R." Blood 116, no. 21 (2010): 4284. http://dx.doi.org/10.1182/blood.v116.21.4284.4284.

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Abstract Abstract 4284 While adoptive T cell therapy is a promising treatment modality for cancer, the optimal approach to generate T cell grafts ex vivo is currently unknown. CD4+ T cells help generate effective immune responses by sustaining CD8+ T cell proliferation, preventing exhaustion, and establishing long-lived functional memory. Incorporation of CD4+ T cell help to expand CD8+ T cells may provide a novel strategy to generate CTL grafts for adoptive therapy. In mouse models, common γ-chain receptor cytokines and CD40/CD40L can mediate CD4+ T cell help. However, CD4+ T cell help in hum

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40

Paszkiet, Brian, Andrew Worden, Yajin Ni, et al. "CD86 and CD54 Co-Expression on VSV-G Pseudotyped HIV-1 Based Vectors Improves Transduction and Activation of Human Primary CD4+ T Lymphocytes." Blood 104, no. 11 (2004): 1754. http://dx.doi.org/10.1182/blood.v104.11.1754.1754.

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Abstract We established the first clinical ex vivo HIV-based vector gene therapy trial in humans with HIV+ CD4+ T-cells. Briefly, this therapy involves modifying patient CD4+ T-cells with our modified lentiviral vector carrying an anti-HIV payload. These cells are then activated and expanded, and re-infused back into the patient. However, cGMP regulations require the use of costly clinical grade reagents (i.e. Retronectin™, CD3/CD28 stimulating paramagnetic beads). In an attempt to reduce ex-vivo processing costs, but not at the expense of transduction levels, we sought to determine a way to d

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41

Paul, Santanu, Charles C. Chu, Brian A. McCarthy, et al. "Activation of Nucleic Acid-Sensing Toll-Like Receptors Induces Proliferation, Cytokine Production, Immunogenic Phenotype, and Plasma Cell Differentiation of CLL Cells and Immunoglobulin Production." Blood 110, no. 11 (2007): 1137. http://dx.doi.org/10.1182/blood.v110.11.1137.1137.

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Abstract Weak immune function of chronic lymphocytic leukemia (CLL) cells may contribute to disease progression and inhibit effective immunotherapy. Accordingly, agents that enhance the function of CLL cells may be useful in immunotherapeutic approaches to this disease. Since Toll-like receptors (TLRs) are major regulators of B-cell function in innate and adaptive immunity, we asked to what extent stimulating two nucleic acid-sensing TLRs affected the activation and differentiation of CLL B cells. Isolated CLL cells were treated with either the TLR7-activating ligand, gardiquimod, or the TLR9-

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42

Zhu, Lv-yun, Li Nie, Tong Shao, Wei-ren Dong, Li-xin Xiang, and Jian-zhong Shao. "B cells in primitive vertebrate act as pivotal antigen presenting cells in priming adaptive immunity (P5035)." Journal of Immunology 190, no. 1_Supplement (2013): 110.18. http://dx.doi.org/10.4049/jimmunol.190.supp.110.18.

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Abstract The long-held paradigm that B cells are unable to phagocyte large particles has been broken by a new discovery that teleost B cells have potent phagocytic and microbicidal abilities. This finding provides preliminary clues that B cells in primitive vertebrates might act as pivotal antigen presenting cells (APCs) in priming adaptive immunity. In this study, we provide evidence for this suggestion in zebrafish model. By in vitro antigen presentation and in vivo adoptive transfer assays, we found that zebrafish B cells have potent capacity to present both soluble and particulate antigens

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43

Bjørge, Line, Tone Skeie Jensen, Christian A. Vedeler, Elling Ulvestad, Einar K. Kristoffersen, and Roald Matre. "Soluble CD59 in pregnancy and infancy." Immunology Letters 36, no. 2 (1993): 233. http://dx.doi.org/10.1016/0165-2478(93)90058-a.

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44

Zelek, Wioleta, Loek Willems, Ricardo Brandwijk, Sam Loveless, Neil R. Robertson, and B. Paul Morgan. "High levels of soluble CD59 in CSF compared to plasma suggests intrathecal source of soluble CD59." Molecular Immunology 89 (September 2017): 186. http://dx.doi.org/10.1016/j.molimm.2017.06.179.

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45

Stachel, Daniel K., Uta Eickelmann, Rita Meilbeck, et al. "Coculture of Pediatric Acute Lymphoblastic Leukemia (ALL) Blasts with CD40 Ligand Transfected Cells Leads to Changes of Surface Antigens and RNA Expression." Blood 106, no. 11 (2005): 856. http://dx.doi.org/10.1182/blood.v106.11.856.856.

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Abstract Although multi-agent chemotherapy is remarkably successful in the treatment of pediatric acute lymphoblastic leukemia (ALL), about 25% of patients experience relapse. A possible way to increase the cure rate for leukemia could be to modulate the immune response against leukemic cells. It is known that ALL blasts are poor stimulators of cellular immune responses. This is believed to be mainly the result of a reduced presentation of costimulatory molecules on the surface of the ALL blasts. For B cells, CD40 is an essential molecule which can be targeted therapeutically through its ligan

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46

van der Merwe, P. Anton, Dale L. Bodian, Susan Daenke, Peter Linsley, and Simon J. Davis. "CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics." Journal of Experimental Medicine 185, no. 3 (1997): 393–404. http://dx.doi.org/10.1084/jem.185.3.393.

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The structurally related T cell surface molecules CD28 and CTLA-4 interact with cell surface ligands CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells (APC) and modulate T cell antigen recognition. Preliminary reports have suggested that CD80 binds CTLA-4 and CD28 with affinities (Kd values ∼12 and ∼200 nM, respectively) that are high when compared with other molecular interactions that contribute to T cell–APC recognition. In the present study, we use surface plasmon resonance to measure the affinity and kinetics of CD80 binding to CD28 and CTLA-4. At 37°C, soluble recombinant CD80 boun

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47

Tomkinson, B. E., M. C. Brown, S. H. Ip, S. Carrabis, and J. L. Sullivan. "Soluble CD8 during T cell activation." Journal of Immunology 142, no. 7 (1989): 2230–36. http://dx.doi.org/10.4049/jimmunol.142.7.2230.

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Abstract The CD8 Ag has long been used as a surface marker for the identification of cytotoxic and suppressor cells. Recently CD8-positive cells have been shown to release a soluble form of the CD8 Ag. We have devised a sandwich monoclonal enzyme immunoassay for the quantitation of this released CD8. Soluble CD8 was released in response to lymphocyte activation. In vitro, PHA or anti-CD3 mAb-mediated T cell activation led to release of CD8 into the culture supernatant. In vivo, serum from patients with EBV-induced infectious mononucleosis (IM), a disease associated with intense CD8+ T cell act

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48

Zelek, Wioleta M., Lewis M. Watkins, Owain W. Howell, et al. "Measurement of soluble CD59 in CSF in demyelinating disease: Evidence for an intrathecal source of soluble CD59." Multiple Sclerosis Journal 25, no. 4 (2018): 523–31. http://dx.doi.org/10.1177/1352458518758927.

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Background: CD59, a broadly expressed glycosylphosphatidylinositol-anchored protein, is the principal cell inhibitor of complement membrane attack on cells. In the demyelinating disorders, multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), elevated complement protein levels, including soluble CD59 (sCD59), were reported in cerebrospinal fluid (CSF). Objectives: We compared sCD59 levels in CSF and matched plasma in controls and patients with MS, NMOSD and clinically isolated syndrome (CIS) and investigated the source of CSF sCD59 and whether it was microparticle associa

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49

Nair, Jayakumar R., Louise M. Carlson, Cheryl Rozanski, Lawrence H. Boise, Asher Chanan-Khan, and Kelvin P. Lee. "Direct interaction with dendritic cells through CD28-CD80/CD86 supports plasma cell survival (34.9)." Journal of Immunology 182, no. 1_Supplement (2009): 34.9. http://dx.doi.org/10.4049/jimmunol.182.supp.34.9.

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Abstract The long term survival of plasma cells in their bone marrow niches, necessary to maintain persistent antibody titres, depends on specific survival signals that are produced by their interaction with bone marrow stromal cells (BMSC), interactions that remain largely uncharacterized. Both normal and malignant plasma cells (like myeloma cells) express the T-cell co-stimulatory molecule CD28 and are also known to interact with dendritic cells (DC) in bone marrow biopsies. We also know that ligating CD80/CD86 on DCs with soluble CD28/CTLA4 ligands can up-regulate IL-6, an essential plasma

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50

Butler, Marcus O., Sascha Ansén, Makito Tanaka, et al. "A Series of Human Cell-Based Artificial APC Expands Long-Lived, Th1-Biased, Viral Antigen-Specific CD4+ T Cells with a Central/Effector Memory Phenotpype Restricted by Common HLA-DR Alleles." Blood 116, no. 21 (2010): 354. http://dx.doi.org/10.1182/blood.v116.21.354.354.

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Abstract Abstract 354 Adoptive cell therapy utilizes unique mechanisms of action to prevent the development of infections in immunocompromised patients and treat chemotherapy resistant malignancies. In adoptive cell therapy, the major effector cells appear to be CD8+ T cells, since they are armed with antigen-specific effector functions, i.e. cytotoxicity and cytokine secretion. However, the roles of antigen-specific CD4+ T cells in T cell immunity are also critical. In immunocompromised patients adoptively transferred with CMV-specific CD8+ T cells, long-term in vivo persistence was achieved

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