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Dissertations / Theses on the topic 'Soluble epoxide hydrolase subdomains'

Author: Grafiati

Published: 18 May 2024

Last updated: 31 July 2025

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1

Varennes, Olivier. "Le rôle de l'Epoxyde hydrolase soluble (sEH) dans la physiopathologie des calcifications vasculaires." Electronic Thesis or Diss., Amiens, 2018. http://www.theses.fr/2018AMIE0046.

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L'Epoxide Hydrolase soluble (sEH) est une enzyme exprimée dans les vaisseaux. Elle possède un domaine hydrolase à l'extrémité COOH-term (sEH-H) qui métabolise des facteurs vasodilatateurs et anti-inflammatoires comme les acides époxyeicosatriénoïques (EETs). Elle possède également un domaine phosphatase à l'extrémité NH2-term (sEH-P) dont le rôle biologique n'est pas totalement élucidé. Afin de comprendre le rôle de sEH-H et sEH-P dans la calcification vasculaire, des anneaux aortiques de rats et des cellules musculaires lisses vasculaires humaines (CMLVh) ont été exposés à des conditions proc

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2

Sellers, Kathleen Walworth. "Role of brain soluble epoxide hydrolase in cardiovascular function." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0008356.

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Thesis (Ph.D.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 156 pages. Includes Vita. Includes bibliographical references.

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3

Davis, Benjamin Boyce. "Novel treatments for atherosclerosis with inhibitors of soluble epoxide hydrolase /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2005. http://uclibs.org/PID/11984.

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4

Sandberg, Martin. "Mammalian soluble epoxide hydrolase : studies on gene structure and expression /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 2000. http://epsilon.slu.se/avh/2000/91-576-5747-5.pdf.

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5

Varennes, Olivier. "Le rôle de l'Epoxyde hydrolase soluble (sEH) dans la physiopathologie des calcifications vasculaires." Thesis, Amiens, 2018. http://www.theses.fr/2018AMIE0046/document.

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L'Epoxide Hydrolase soluble (sEH) est une enzyme exprimée dans les vaisseaux. Elle possède un domaine hydrolase à l'extrémité COOH-term (sEH-H) qui métabolise des facteurs vasodilatateurs et anti-inflammatoires comme les acides époxyeicosatriénoïques (EETs). Elle possède également un domaine phosphatase à l'extrémité NH2-term (sEH-P) dont le rôle biologique n'est pas totalement élucidé. Afin de comprendre le rôle de sEH-H et sEH-P dans la calcification vasculaire, des anneaux aortiques de rats et des cellules musculaires lisses vasculaires humaines (CMLVh) ont été exposés à des conditions proc

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6

Newman, John William. "Novel tools for the investigation of the endogenous role of soluble epoxide hydrolase /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2002. http://uclibs.org/PID/11984.

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7

Codony, Gisbert Sandra. "From the design to the in vivo evaluation of novel soluble epoxide hydrolase inhibitors." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671480.

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Epoxieicosatrienoic acids acids (EETs) are endogenous chemical mediators derived from arachidonic acid that show anti-inflammatory, antihypertensive, analgesic, angiogenic and antiatherosclerotic effects. Soluble epoxide hydrolase (sEH) converts EETs to their corresponding dihydroxyeicosatrienoic acids, whereby the biological effects of EETs are diminished, eliminated, or altered. Therefore, it has been proposed that inhibition of sEH may have therapeutic effects in various inflammatory and pain-related diseases. A number of very potent sEH inhibitors (sEHIs) have been developed, several of th

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8

Duflot, Thomas. "Rôle de l'époxyde hydrolase soluble dans les maladies cardiovasculaires." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMR037.

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L’époxyde hydrolase soluble (sEH) est une enzyme ubiquitaire, bifonctionnelle, codée par le gène EPHX2. La partie hydrolase (sEH-H) est responsable de la dégradation de facteurs endothéliaux vasodilatateurs, les acides époxyeicosatriénoïques (EETs), alors que la partie phosphatase (sEH-P) est impliquée dans le métabolisme des acides lysophosphatidiques (LPAs).L’objectif de ce travail a été de développer des outils méthodologiques permettant d'évaluer le rôle de la sEH dans la physiopathologie des maladies cardiovasculaires.Nous avons développé une méthode de quantification par CLHP-MS² des EET

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9

Feugray, Guillaume. "Evaluatiοn translatiοnnelle de l’activité phοsphatase de l’épοxyde hydrοlase sοluble au cοurs des maladies cardiοmétabοliques". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMR101.

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L’époxyde hydrolase soluble (sEH) est une enzyme bifonctionnelle codée par le gène EPHX2 et qui présente une activité hydrolase (sEH-H) sur son domaine C-terminal et une activité phosphatase (sEH-P) sur son domaine N-terminal. La sEH-H est impliquée dans le métabolisme des acides gras époxydés et plus particulièrement des acides époxyeicosatriénoïques (EETs). Ils présentent des effets vasodilatateurs, pro-angiogéniques et anti-inflammatoires. Ils sont métabolisés en dérivés diols biologiquement moins actifs par la sEH-H. Actuellement, des inhibiteurs pharmacologiques sont en cours d’investigat

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10

Leuillier, Matthieu. "Rôle de l'activité phosphatase de l'époxyde hydrolase soluble dans la régulation de l'homéostasie métabolique et cardiovasculaire. In vivo inactivation of the phosphatase activity of soluble epoxide hydrolase potentiates brown adispose thermogenesis and protects against cardiovascular damage and remodeling Discovery of the first in vivo active inhibitors of the soluble epoxide hydrolase phosphatase domain Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR150.

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Près de 40 ans après sa découverte initiale en 1972, il a été montré en 2003 que l'époxyde hydrolase soluble (sEH), codée par le gène EPHX2, est une protéine bifonctionnelle qui présente non seulement une activité époxyde hydrolase au niveau de sa partie C-terminale mais également une activité lipidophosphatase sur son domaine N-terminal. En effet, au niveau de sa partie C-terminale, l’activité hydrolase métabolise des époxydes d'acides gras polyinsaturés. Notamment, elle transforme les acides époxyeicosatriénoïques, facteurs vasodilatateurs et anti-inflammatoires biologiquement actifs générés

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11

Kamynina, Alisa. "Furthering the understanding of the redox control of soluble epoxide hydrolase and protein kinase G in the cardiovascular system." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/furthering-the-understanding-of-the-redox-control-of-soluble-epoxide-hydrolase-and-protein-kinase-g-in-the-cardiovascular-system(f6909a1e-6b09-4c3b-8d36-b7e417f45a1d).html.

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Redox regulation of proteins represents an important control mechanism that can finely tune cell homeostasis or responses to stress. Two proteins regulated in this way include soluble epoxide hydrolase (sEH) and protein kinase G (PKG). sEH hydrolyses epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs), which are less potent in terms of their ability to dilate blood vessels and lower blood pressure (BP) or induce angiogenesis. Thus inhibitors of sEH, which include lipid electrophiles, that adduct to C521, increase EET levels. As sepsis is a time of oxidative stress when li

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Zhao, Wei. "Further Characterization of Recombinant Epoxide Hydrolase Kau2 Derived from Metagenomic DNA and Application in Biocatalytic Reactions." Electronic Thesis or Diss., Ecole centrale de Marseille, 2014. http://www.theses.fr/2014ECDM0008.

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Les chimistes organiciens disposent à l'heure actuelle des outils de la biocatalyse afin d'accéder aux produits de la chimie fine et en particulier à des synthons et des molécules optiquement enrichies. Dans ce cadre, le travail de thèse présenté dans ce mémoire a été conduit afin d'enrichir notre connaissance sur une époxyde hydrolase (EH) découverte après analyse métagénomique d'un bio-filtre. Afin de pouvoir mener une étude de mutagénèse dirigée de sorte à améliorer certaines propriétés de cette enzyme appelée Kau2-EH, un modèle de l'enzyme a été élaboré sur la base de la structure tridimen

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Mavrommatis, Ioannis. "The effects of dietary long chain n-3 polyunsaturated fatty acids on soluble epoxide hydrolase and related markers of cardiovascular health." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=56261.

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14

Hefke, Lena [Verfasser], Ewgenij [Gutachter] Proschak, and Stefan [Gutachter] Knapp. "Using fingerprints and machine learning tools for the prediction of novel dual active compounds for leukotriene A4 hydrolase and soluble epoxide hydrolase / Lena Hefke ; Gutachter: Ewgenij Proschak, Stefan Knapp." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2020. http://d-nb.info/122685320X/34.

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Johnson, Clinton L. "Mechanisms of Prenatal High-Salt "Fetal Programming" Resulting in Stress Hyperresponsiveness in The Adult Female Offspring in The Sprague Dawley Rat." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2830.

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Female offspring of Sprague-Dawley rats fed a high-salt diet (HS) during pregnancy show an enhancement of mean arterial pressure (MAP) and heart rate (HR) response to acute stress in adulthood compared to offspring whose mothers were fed a normal-salt diet (NS) [1]. In the present study, we first examined the expression of soluble epoxide hydrolase (SEH) protein in brain tissue. Whole brains were collected and SEH gene (EPHX2) mRNA and SEH protein expression were analyzed using RT-PCR and Western blot, respectively. mRNA levels were relatively decreased in high-salt rats (1.0 ± 0.32 NS vs 0.39

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Zhao, Wei. "Further Characterization of Recombinant Epoxide Hydrolase Kau2 Derived from Metagenomic DNA and Application in Biocatalytic Reactions." Thesis, Ecole centrale de Marseille, 2014. http://www.theses.fr/2014ECDM0008/document.

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Les chimistes organiciens disposent à l'heure actuelle des outils de la biocatalyse afin d'accéder aux produits de la chimie fine et en particulier à des synthons et des molécules optiquement enrichies. Dans ce cadre, le travail de thèse présenté dans ce mémoire a été conduit afin d'enrichir notre connaissance sur une époxyde hydrolase (EH) découverte après analyse métagénomique d'un bio-filtre. Afin de pouvoir mener une étude de mutagénèse dirigée de sorte à améliorer certaines propriétés de cette enzyme appelée Kau2-EH, un modèle de l'enzyme a été élaboré sur la base de la structure tridimen

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17

Messaoudi, Hind boutheina. "Impacte de l'inhibition de l'activité phosphatase de l'époxyde hydrolase soluble dans les calcifications cardiovasculaires." Electronic Thesis or Diss., Normandie, 2023. http://www.theses.fr/2023NORMR051.

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Les calcifications cardiovasculaires, également appelées calcifications ectopiques, sont un phénomène pathologique très fréquent. Leur développement est étroitement associé au vieillissement, au diabète, à l’hypertension artérielle, à l’athérosclérose et à l’insuffisance rénale chronique. L'apparition et la progression de ces calcifications augmentent le risque d’évènements cardiovasculaires chez les patients. Il est désormais reconnu que les calcifications cardiovasculaires sont le résultat d’un processus actif conduisant à la formation de dépôts de cristaux d’hydroxyapatite, qui présente des

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Wolf, Nicola M. [Verfasser], Bertold [Akademischer Betreuer] Hock, Bruce D. [Akademischer Betreuer] Hammock, and Siegfried [Akademischer Betreuer] Scherer. "Inhibition studies of soluble epoxide hydrolase : Development of two novel fluorescence-based inhibitor assay systems and cellular inhibition by RNAi / Nicola M. Wolf. Gutachter: Siegfried Scherer. Betreuer: Bertold Hock ; Bruce D. Hammock." München : Universitätsbibliothek der TU München, 2006. http://d-nb.info/1058141368/34.

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Silva, Carlos Antonio Trindade da. "O Uso terapêutico de mediadores anti-inflamatórios da via do ácido araquidônico." Universidade Federal de Uberlândia, 2016. https://repositorio.ufu.br/handle/123456789/17681.

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O ácido araquidônico (AA) é precursor na formação dos eicosanoides, que são mediadores lipídicos com uma série de funções na fisiologia e patologia humana. A maioria dos eicosanoides atuam como mediadores pró-inflamatórios e contribuem para o desenvolvimento e proliferação de tumores. Nesta tese foram avaliados dois mediadores: a 15-deoxi-Δ12,14-PGJ2 (15d- PGJ2) e os ácidos Epoxieicosatrienoicos (EETs), ambos apresentam uma atividade oposta a da maioria dos eicosanoides, ou seja, com uma ação anti-inflamatória e antitumoral. Esses dois mediadores distintos da via do AA foram utilizados nesta t

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Schmidt, Cosima. "Identifizierung, molekulare Eigenschaften und Regulation einer renalen 20-Hydroxyeicosatetraensäure-Synthase." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15876.

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Cytochrom P450 (CYP)-Enzyme hydroxylieren und epoxydieren Arachidonsäure (AA) zu bioaktiven Metaboliten wie 20-Hydroxyeicosatetraensäure (20-HETE) und Epoxyeicosatriensäuren (EETs). Diese CYP-abhängigen Eicosanoide fungieren als Mediatoren bei der Regulation der Gefäß-, Nieren- und Herzfunktion. Hauptziel der vorliegenden Arbeit war es, die Identität der 20-HETE bildenden CYP-Isoformen in der Mausniere aufzuklären. Ein weiterer Schwerpunkt war die Bestimmung von Veränderungen im Metabolismus CYP-abhängiger Eicosanoide in Tiermodellen des akuten Nieren- und Herzversagens. Zur Identifizierung

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Yen, Hsin-Ju, and 顏欣如. "Roles of soluble epoxide hydrolase inhibitor in emotional behavior." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/64023860197755509012.

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碩士<br>國立陽明大學<br>生理學研究所<br>104<br>Soluble epoxide hydrolase（sEH）expression is widespread in cortex, striatum and amygdala. It is a bifunctional enzyme with N- and C-terminal domains. The C-terminal domain is responsible for the epoxide hydrolase activity. EETs are hydrolyzed by sEH into less active dihydroxyeicosatrienoic acids (DHET). The sEH C-terminal epoxide hydrolase inhibitor 12-（3-adamantan-1-yl-ureido）-dodecanoic acid（AUDA）elevated the endogenous EETs , i.e. 14,15-EET, be a beneficial therapeutic treatment in various diseases. Previous studies from our laboratory show that AUDA facilita

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Chen, Yi-Ju, and 陳怡如. "Effect of soluble epoxide hydrolase inhibition on synaptic plasticity." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/336q5s.

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碩士<br>國立陽明大學<br>生理學研究所<br>105<br>The epoxygenases are a subgroup of enzymes in the cytochrome P450 (CYP 450) family that metabolize arachidonic acid (AA) into four regioisomers of epoxyeicosatrienoic acid (5,6-, 8,9-, 11,12-, and 14,15-EETs). EETs are metabolized into dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). Many experimental evidences show that EETs are potent vasodilators, pro-angiogenic and anti-inflammatory effects in rodent. In brain, EETs also protect neurons from ischemia-reperfusion injury. Previous study has demonstrated higher levels of 14,15-EET in s

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Chen, I.-Chih, and 陳奕志. "Soluble Epoxide Hydrolase Inhibition Reduces Ischemic Infarction and Neuroexcitation by TrkB Activation." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/nnbt7h.

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碩士<br>國立陽明大學<br>腦科學研究所<br>105<br>Pharmacological inhibition and gene deletion of soluble epoxide hydrolase (sEH) has been suggested to ameliorate infarction in preclinical ischemic stroke by preventing metabolism of beneficial epoxyeicosatrienoic acids. However, it is unclear whether the neuroprotection of sEH inhibition involves alteration of post-ischemic excitatory transmission and neurotrophic signaling. Here, a permanent middle cerebral artery occlusion (MCAO) model was used in adult wild-type and sEH knockout (sEH KO) mice, and wild-type mice were treated with sEH hydrolase inhibitor 12-

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Fife, Kimberly L. "Soluble epoxide hydrolase as a target for modulation of the inflammatory response." Diss., 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3295022.

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Hsiao, Yu-Yieh, and 蕭郁曄. "Role of Soluble Epoxide Hydrolase in Microglia Activation under Oxygen-glucose Deprivation/Reperfusion Stress." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/87845303673907025817.

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碩士<br>國立陽明大學<br>解剖學及細胞生物學研究所<br>103<br>Abstract Key word: ischemic-hypoxia, microglia activation, soluble epoxide hydrolase. Ischemic-hypoxia with lack of blood flow caused vascular diseases including cardiac ischemia and stroke. Mild ischemic-hypoxia stress which resulted from stenosis or blockade at vascular is a cause of morbidity and mortality leading to cell death and neurological disability in the affected brain area. After ischemic-hypoxia stimulation, brain ischemia-reperfusion increases perivascular inflammation and neurovascular unit permeability in penumbra region and contributi

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Homburg, Shirli [Verfasser]. "Biochemical analysis of the phosphatase domain of the human soluble epoxide hydrolase (sEH) / Shirli Homburg." 2010. http://d-nb.info/101190019X/34.

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Hou, Hsin-Han, and 侯欣翰. "Phosphatase activity of soluble epoxide hydrolase negatively regulates the activation of endothelial nitric oxide synthase." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/58629548340501094245.

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博士<br>國立陽明大學<br>生理學研究所<br>100<br>Soluble epoxide hydrolase (sEH) expresses in endothelial cells (ECs) and is a bifunctional enzyme with C-terminal hydrolase and N-terminal phosphatase activities. The implication of hydrolase activity of sEH in the metabolism of antiinflammative and antihypertensive epoxyeicosatrienoic acid has been well documented and suggested inhibition of sEH hydrolase activity may serve as a therapeutic strategy for treatment with hypertension. However little is known about the protein substrates and associated physiological role of sEH phosphatase. Endothelium-derived nit

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WEN, SHIN, and 温芯. "The Neuroprotective Effects and Anti-Inflammatory Mechanisms of Soluble Epoxide Hydrolase Inhibition in Experimental Intracerebral Hemorrhage." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/47385041676452135541.

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碩士<br>國防醫學院<br>生理學研究所<br>104<br>Intracerebral hemorrhage (ICH) accounts for 10–15% of all strokes, but it is associated with high mortality and morbidity. Also, there are no effective drug therapies available at present. Following ICH, danger signals from damaged neurons and blood components such as thrombin and heme trigger inflammatory processes through the MAPK-NF-κB pathway. Epoxyeicosatrienoic acids (EETs), a product of arachidonic acid metabolized through cytochrome P450, have been shown to suppress the NF-κB inflammatory pathway and reduce brain damage after brain injuries. However, EET

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Chen, Jia-Wei, and 陳嘉偉. "Dual-Wavelength Optical Neural Image on Functional Recovery of Ischemic Stroke with Soluble Epoxide Hydrolase Inhibitors Treatmen." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/14851404541135899095.

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碩士<br>國立陽明大學<br>生物醫學工程學系<br>103<br>Stroke is a cerebrovascular disease that is caused by the blockage of blood vessels, which can result in permanent neurological damage or death. Previous studies have shown that 12-(3-adamantan-1-yl-ureido) dodecanoic acid (AUDA) can lead to protection mechanisms of the brain, heart and kidney. However, the exact mechanism of this phenomenon still remains unclear. Though there has been much research focused on stroke, the treatment options in the acute phase of stroke are still limited. Normally neural activity is accompanied by changes in the local oxygenati

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Chang, Yun-Chi, and 張芸綺. "The Role of Soluble Epoxide Hydrolase in High Fat Diet-induced Metabolism and Brain Function in Mice." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/geter5.

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碩士<br>國立陽明大學<br>生理學研究所<br>107<br>High fat diet (HFD) is a common cause of obesity accompanied by not only metabolic syndrome, but also brain insulin resistance and inflammation that altered brain insulin signaling such as insulin receptor substrate-1 (IRS-1), protein kinase B (Akt) and glycogen synthase kinase-3β (GSK-3β). Moreover, HFD may also increase the risk of impaired memory and hippocampal long-term potentiation (LTP) which forms of synaptic plasticity and plays an important role in the formation of memories. Additionally, soluble epoxide hydrolase (sEH) is an enzyme that metabolizes e

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Wong, Lin-Kin, and 黃勵健. "The Effect of Soluble Epoxide Hydrolase Inhibition on Seizure Generation in Two Mouse Models of Temporal Lobe Epilepsy." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/40294122701077458022.

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碩士<br>國立陽明大學<br>腦科學研究所<br>102<br>Background: Temporal lobe epilepsy (TLE), a common neurological disease with hallucinations and disturbance of consciousness, is the abnormal neurological activity of brain. Although the condition responds well to antiepileptic drugs (AEDs), there are still unresponsive to antiepileptic drug in about 1/3 of cases. Other treatment including surgical discectomy and deep brain stimulation, also limited to the lesion location which is not easily removed or restricted unclear. Thus, the development of new AEDs needs to be discovered for the treatment of drug resista

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Wu, Yi-Chen, and 吳苡禎. "Effects of Soluble Epoxide Hydrolase on Epileptogenesis: A study in A Kindling Model of Temporal Lobe Epilepsy in Mice." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/18378754175983896649.

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碩士<br>國立陽明大學<br>腦科學研究所<br>101<br>Temporal lobe epilepsy (TLE), a common neurological disease with hallucinations and disturbance of consciousness, is the abnormal neurological activity in any part of brain. Although the condition responds well to antiepileptic drugs (AEDs), there are still unresponsive to antiepileptic drug in about 1/3 of cases. Other treatment including surgery and deep brain stimulation (DBS), are also limited to the lesion location is not easily removed or restricted unclear. In addition, little is known about the underlying mechanism of the disease, deepened the difficult

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Yeh, Chien-Fu, and 葉建甫. "Inhibition of soluble epoxide hydrolase regulates microglia polarization and improves neurological outcomes in a rat model of ischemic stroke." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/ttrn5z.

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Hu, Ya-Yu, and 胡雅瑜. "Effects of Genetic and Pharmacological Inhibitions of Soluble Epoxide Hydrolase on Kainic Acid-induced Memory Impairment and Loss of Hippocampal GABAergic Interneurons in Mice." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/6ap3y6.

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碩士<br>國立陽明大學<br>生理學研究所<br>106<br>Soluble epoxide hydroxylase (sEH) is a dual activity enzyme with the C-terminal epoxide hydrolase domain and an N-terminal lipid phosphatase domain and is expressed in mammalian brains, especially hippocampus. Inhibition of sEH hydrolase activity has been proven to be protective against ischemic brain injury, but it was also reported to facilitate synaptic plasticity. Synaptic plasticity in the hippocampus is an important role to improve memory function. Also, previous studies demonstrated that inhibition of GABAergic interneuron activity impaired memory functi

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Keserü, Benjamin [Verfasser]. "Role of the soluble epoxide hydrolase and cytochrome P450-derived epoxyeicosatrienoic acids in hypoxic pulmonary vasoconstriction and hypoxia induced pulmonary vascular remodelling / von Benjamin Keserü." 2009. http://d-nb.info/992453011/34.

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Jíchová, Šárka. "Úloha metabolitů kyseliny arachidonové v regulaci krevního tlaku u experimentálních modelů ANGII-dependentní formy hypertenze." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-436095.

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Abstract:

Introduction: Two major product groups originate from the arachidonic acid metabolic pathway of cytochromes P450: epoxyeicosatrienoic acid (EETs) and 19 and 20-hydroxyeicosatetraenoic acid (19- and 20-HETE). These metabolites play an important role in the regulation of blood pressure, inflammatory responses, regulation of sodium excretion and other crucial physiological processes. Hypothesis: Our studies were based on the hypothesis that abnormalities in the production and function of these cytochrome P450 metabolites significantly contribute to the pathophysiology of hypertension development,

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Honetschlägerová, Zuzana. "Úloha epoxyeicosatrienových kyselin v regulaci krevního tlaku a renálních funkcí u experimentálních modelů hypertenze." Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-389786.

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Abstract:

Introduction: Epoxyeicosatrienoic acids (EETs) are converted by the enzyme soluble epoxid hydrolase (sEH) to the biologically inactive dihydroxyeicosatrienoic acids (DHETs). EETs are significantly involved in the control of blood pressure, they influence vascular tone and renal transport mechanism. sEH inhibitor reduce blood pressure by increasing the bioavailability of EETs in many models of hypertension. Aim of the study: To determine that sEH inhibitor decreases blood pressure and improves the renal function during the development of malignant hypertension in transgenic rats after the induc

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