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Dissertations / Theses on the topic 'Soluble guanylyl cyclase stimulator'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Wales, Jessica A., Cheng-Yu Chen, Linda Breci, et al. "Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase." AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2018. http://hdl.handle.net/10150/627055.

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Soluble guanylyl cyclase (sGC) is the receptor for nitric oxide and a highly sought-after therapeutic target for the management of cardiovascular diseases. New compounds that stimulate sGC show clinical promise, but where these stimulator compounds bind and how they function remains unknown. Here, using a photolyzable diazirine derivative of a novel stimulator compound, IWP-051, and MS analysis, we localized drug binding to the 1 heme domain of sGC proteins from the hawkmoth Manduca sexta and from human. Covalent attachments to the stimulator were also identified in bacterial homologs of the s

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2

Nedvetsky, Pavel I. "Regulation of the nitric oxide receptor, soluble guanylyl cyclase." Doctoral thesis, [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969682026.

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3

Delago, Antonia. "Functional analysis of soluble guanylyl cyclase expression in insects." Thesis, Queen Mary, University of London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407766.

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4

MA, Xiaolei. "Structural Studies of Soluble Guanylyl Cyclase and Its Bacterial Homologs." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1208379599.

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5

Ogley, Scott Carson. "Structure and Function of Manduca Sexta Soluble Guanylyl Cyclase PASα Domain". Thesis, The University of Arizona, 2011. http://hdl.handle.net/10150/144916.

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6

Fritz, Bradley. "MOLECULAR MODEL OF SOLUBLE GUANYLYL CYCLASE: INSIGHT INTO ALLOSTERY IN NITRIC OXIDE SIGNALING." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/205214.

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Soluble guanylyl cyclase (sGC), the nitric oxide (NO) receptor, is a 150 kDa heterodimeric multi-domain protein that contains heme in the β subunit. Binding of NO to heme leads to rupture of the proximal histidine bond, increased catalytic conversion of GTP to cGMP at a distant guanylyl cyclase catalytic domain, and vasodilation through cGMP signaling. The structure of sGC has not been determined, and little is known about the mechanism by which NO binding to heme leads to increased catalysis. The small molecule YC-1 is known to stimulate sGC activity, but the exact YC-1 binding site and mecha

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7

Purohit, Rahul. "The Mechanism of Allosteric Regulation in Soluble Guanylate Cyclase." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/333219.

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Nitric oxide (NO), a reactive diatomic gas and a potent signaling molecule, is required for proper cardiovascular functioning. Soluble guanylate cyclase (sGC), a heterodimeric heme protein, is the key intracellular NO receptor protein which, upon NO binding, undergoes conformational changes leading to catalysis and the cGMP signaling cascade. Several small molecules that allosterically stimulate sGC have been developed for treatment of pulmonary hypertension, but little is known about their binding site or how they stimulate activity. This dissertation describes experiments designed to uncover

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8

Chia, Karin Kim Mae. "Soluble guanylyl cyclase modulates redox-dependent regulation of the cardiac sodium potassium pump." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/9464.

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Modulation of redox-dependent regulation of the Na+-K+ pump is a potential therapeutic strategy in heart failure. This Thesis examined if stimulation of soluble guanylyl cyclase (sGC) can modulate oxidative signalling to the Na+-K+ pump in rabbit cardiomyocytes and the mechanisms by which this may occur. sGC stimulation with 3-(5’-hydroxymethyl-2’-furyl)-1-benzylindazole (YC-1) attenuated the Angiotensin (Ang) II-induced 1) inhibition of the electrogenic Na+-K+ pump current (Ip), 2) O2•-sensitive fluorescence, 3) serine phosphorylation of p47phox (necessary for NADPH oxidase activation) and

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9

Yamamoto, Takehiro, Yuki Moriya, Norio Suzuki та Chikako Morinaga. "Identification of tandem organization of soluble guanylyl cyclase α_1 and β_1 subunit genes in the Japanese pufferfish (Fugu rubripes) genome: comparison with their human homologues". Laboratory of Freshwater Fish Stocks Bioscience and Biotechnology Center Nagoya University, 2007. http://hdl.handle.net/2237/13831.

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10

Gao, Shuai. "The Pro-Survival Functions of Soluble Guanylyl Cyclase Alpha-1 (sGCa1) and Zinc Finger Protein 280B (ZNF280B) in Prostate Cancer." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1373307941.

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11

Welshhans, Kristy. "Neuronal growth cone dynamics are regulated by a nitric oxide-initiated second messenger pathway." unrestricted, 2007. http://etd.gsu.edu/theses/available/etd-09282007-114034/.

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Thesis (Ph. D.)--Georgia State University, 2007.<br>Vincent Rehder, committee chair; Sarah Pallas, Walter William Walthall, committee members. Electronic text (248 p. : ill. (some col.)) : digital, PDF file. Description based on contents viewed Jan. 28, 2008; title from file title page. Includes bibliographical references (p. 218-248).

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12

Sugino, Kentaro. "Structure and dynamics of soluble guanylyl cyclase." Thesis, 2005. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2005-056.

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13

Carr, Heather S. "Activation and inhibition of soluble guanylyl cyclase." 2000. http://www.library.wisc.edu/databases/connect/dissertations.html.

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14

Tsou, Chia-Yuan, and 鄒佳芫. "Activation of Soluble Guanylyl Cyclase Suppresses Atherosclerosis." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/86652760361318911889.

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碩士<br>國立陽明大學<br>生理學研究所<br>99<br>Soluble guanylyl cyclase (sGC) plays pivotal roles in vascular cells including endothelial cells (ECs) and vascular smooth muscle cells (VSMCs). Dysregulation of sGC results in EC dysfunction and the progression of vascular diseases. In contrast, activation of sGC promotes vasorelaxation and the inhibition of proliferation and migration of VSMCs. Moreover, the expression and activity of sGC are altered in atherosclerotic lesions. However, the role and detailed mechanism of sGC in macrophages of atherosclerotic lesions are largely unknown. Therefore, we investiga

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15

Cherney, Melisa M. "Studies of the heme proteins soluble guanylyl cyclase and cystathionine beta-synthase." 2007. http://www.library.wisc.edu/databases/connect/dissertations.html.

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16

Hwang, Tsong-Long, and 黃聰龍. "Pharmacological Characterization of YC-1, a Soluble Guanylyl Cyclase Activator, in Airway." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/06653799530625385309.

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博士<br>國立臺灣大學<br>藥理學研究所<br>88<br>Soluble guanylyl cyclase (sGC) plays a pivotal role in the transduction of inter- and intracellular signals conveyed by nitric oxide (NO). Due to the ubiquitous nature of NO, signal transduction induced by sGC/cyclic GMP also has profound physiological as well as pathophysiological significance. However, the role of sGC/cyclic GMP pathway in the pathogenesis of airway function is currently unclear. Thus, it is crucial that elucidation of the NO/sGC/cyclic GMP may provide the greatest opportunity for the design and development of therapeutic agents for airway dis

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17

Yu, Anita Eunyoung. "Spectroscopic studies on the mechanism of activation of soluble guanylyl cyclase by nitric oxide." 1993. http://catalog.hathitrust.org/api/volumes/oclc/31370135.html.

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18

Nedvetsky, Pavel I. [Verfasser]. "Regulation of the nitric oxide receptor, soluble guanylyl cyclase / vorgelegt von Pavel I. Nedvetsky." 2003. http://d-nb.info/969682026/34.

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19

Kim, Thomas Dongbum. "Identification and characterization of an endogenous inhibitor of soluble guanylyl cyclase from bovine lung." 1993. http://catalog.hathitrust.org/api/volumes/oclc/31467903.html.

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20

Srivastava, Rashi [Verfasser]. "Molecular mechanisms affecting expression of the NO receptor soluble guanylyl cyclase (sGC) / von Rashi Srivastava." 2006. http://d-nb.info/982425651/34.

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21

Lee, Pei-Yu, and 李佩育. "Attenuation of Endothelin-1 Regulates Rho-kinase And Soluble Guanylyl Cyclase Pathways After Subarachnoid Hemorrhage." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/53796213428227148629.

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碩士<br>高雄醫學大學<br>藥理學研究所<br>96<br>Subarachnoid hemorrhage (SAH) is an important subcategory of stroke, because of its unacceptably high levels of mortality, as well as severe complications, such as cerebral vasospasm, neurological deficit and cardiopulmonary abnormality. Many evidences have shown that endothelin-1 (ET-1), a potent vasoconstrictor, plays a pivotal role in cerebral vasospasm following SAH. Previous researches have shown that blocking ET-1 biosynthesis with CGS 26303, an endothelin-converting enzyme (ECE) inhibitor, could effectively prevent and reverse arterial narrowing in SAH an

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22

Dierks, Elizabeth Ann. "Studies on the mechanisms of activation and deactivation of soluble guanylyl cyclase from bovine lung." 1995. http://catalog.hathitrust.org/api/volumes/oclc/33434600.html.

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23

Hsu, Ting-yun, and 徐婷芸. "Cloning and expression of a soluble guanylyl cyclase gene in the brain of honeybee, Apis mellifera." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/48366318479915362038.

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碩士<br>國立中興大學<br>昆蟲學系<br>93<br>Soluble guanylyl cyclases (sGCs) are an important target for endogenous nitric oxide (NO). sGC are heterodimeric enzymes consisting of α and β subunits, and have been considered as a key factor in the regulation of synthesis of cyclic GMP, a second messenger of signal transduction. The aim of this study is to discover the possible function of sGC in honeybee brain, and to investigate the gene at different ages. The first β1 subunit gene (Amgcβ1) was cloned from the honeybee brain. The Amgcβ1 consisting of 2010 bp contains an open reading frame and encodes a protei

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24

Tsai, Pei-Yi, and 蔡佩宜. "Functional Characterization of Two Distinct Transcripts Encoding the Membrane or Soluble Forms of Guanylyl Cyclase-G." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/01008803031910957093.

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碩士<br>國立陽明大學<br>藥理學研究所<br>96<br>Intracellular second-messenger cGMP is involved in the regulation of a broad spectrum of physiological functions, including relaxation of vascular smooth muscle, repression of platelets coagulation, and electrolytes homeostasis. In the mammal, cGMP is synthesized by two major classes of enzymes: the soluble and the membrane-associated receptor guanylyl cyclases (GCs). To date, seven isoforms of receptor GCs have been described in mammals, termed GC-A to GC-G in the order of their discovery. We recently identified receptor GC-G from mouse testis. However, the exp

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25

Fu, Hwei-Jywan, and 傅惠娟. "Molecular cloning and expression of a cDNA encoding for a soluble guanylyl cyclase in the Oriental fruit fly, Bactrocera dorsalis (Hendel)." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/27910991547680172547.

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碩士<br>國立中興大學<br>昆蟲學系<br>91<br>A cDNA clone encoding for a soluble guanylyl cyclase was isolated from the head of Oriental fruit fly, Bactrocera dorsalis (Hendel), named Bdsgc1 (accession number is AY324653). Bdsgc1 consits of 2680 bp, which contains an open reading frame and encodes a protein of 676 amino acids with a predicted molecular weight of 75.62 kDa. Both identity and similarity of Bdsgc1 are greater than 58% in comparison to Drosophila melanogaster, Rattus norvegicus, Homo sapiens and Manduca sexta soluble guanylyl cyclases, suggesting that the Bdsgc1 is an Oriental fruit fly soluble

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26

Hung, Yu-Chi, and 洪毓棋. "The soluble guanylyl cyclase activator cinaciguat maintains postnatal patency of ductus arteriosus through vasodilatory and anti-remodeling effects in neonatal rats." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/6uqe2r.

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碩士<br>高雄醫學大學<br>醫學研究所碩士班<br>106<br>Ductus arteriosus (DA) patency can be life-saving in some obstructive congenital heart lesions and is achieved by infusion of prostaglandin E1, which unfortunately has lots of side effects. Therefore, an effective and safe agent maintaining DA patency is important in pediatric intensive care but is lacking. DA closure consists of two phases: vasoconstriction and remodeling. We hypothesized that cinaciguat, a soluble guanylyl cyclase (sGC) activator, can maintain DA patency by vasodilatation and anti-remodeling through sGC-PKG signaling. In vivo, we serially e

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27

Reynolds, Mark Fredric. "Studies on the mechanisms of activation of no-sensing soluble guanylyl cyclase from bovine lung and co-sensing CooA from Rhodospirillum rubrum." 1998. http://catalog.hathitrust.org/api/volumes/oclc/42897256.html.

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28

Fillion-Forté, Valérie. "Le syndrome métabolique chez les congéniques du rat Dahl : influence de la diète et rôle du récepteur de l'ANP." Thèse, 2010. http://hdl.handle.net/1866/4285.

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L’hypertension artérielle et l’obésité sont deux composantes conjointement reliées du syndrome métabolique. Les récepteurs de l’ANP (GCA) et de l’oxyde nitrique (GCs) ont des propriétés diurétiques, natriurétiques, vasodilatatrices et sont liés au contrôle de la pression. Des études récentes ont démontré leur implication dans l’obésité. Hypothèse : Une différence génétique au niveau du gène GCA pourrait contribuer à des différences physiologiques. La composante lipidique et/ou sodique de la diète pourrait influencer la fonction rénale, cardiaque et les valeurs anthropométriques différemment ch

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29

"Role of nitric oxide (NO), NO synthases and soluble guanylyl cyclase/cGMP/protein kinase G signaling pathway in the regulation of apoptosis and cell proliferation in pancreatic islets and ovarian cancer cells." Thesis, 2006. http://library.cuhk.edu.hk/record=b6074229.

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In the studies about ovarian cancer cells, basal iNOS expression in the chemosensitive OV2008 cells was significantly higher than in the chemoresistant C13* cells. Cisplatin further increased iNOS expression in OV2008 cells, but had no effect in C13* cells. Furthermore, cisplatin dramatically reduced the expression levels of eNOS and nNOS, but again only in OV2008 cells. The data suggest that failure of cisplatin to upregulate iNOS and downregulate eNOS and nNOS in C13* cells could be an etiological factor in chemoresistance. Addition of exogenous NO at high levels, using SNAP, significantly i

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30

Pinto, Isa Eunice Costa Figueiredo Paula. "The role of cGMP on adenosine A1 receptor-mediated inhibition of synaptic transmission at the hippocampus." Master's thesis, 2014. http://hdl.handle.net/10400.6/5663.

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The adenosine A1 receptor is highly expressed in hippocampus where it inhibits synaptic transmission and has neuroprotective activity. Similar actions are obtained by increasing the concentration of the second messenger cGMP and recently it was found that activation of adenosine A1 receptor increased cGMP levels in the nervous system, but the role of cGMP on adenosine A1 receptor mediated inhibition of synaptic transmission remains to be established. This work addressed if the adenosine A1 receptor inhibitory effect on neurotransmission is dependent on the cGMP pathway. To answer this question

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