Academic literature on the topic 'Solute carrier family 2'

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Journal articles on the topic "Solute carrier family 2"

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Gibson, Charlotte, Marta de Ruijter-Villani, Jolanda Rietveld, and Tom A. E. Stout. "Amino acid transporter expression in the endometrium and conceptus membranes during early equine pregnancy." Reproduction, Fertility and Development 30, no. 12 (2018): 1675. http://dx.doi.org/10.1071/rd17352.

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Maternally derived amino acids (AA) are essential for early conceptus development, and specific transporters enhance histotrophic AA content during early ruminant pregnancy. In the present study we investigated AA transporter expression in early equine conceptuses and endometrium, during normal pregnancy and after induction of embryo–uterus asynchrony. ‘Normal’ conceptuses and endometrium were recovered on Days 7, 14, 21 and 28 after ovulation. To investigate asynchrony, Day 8 embryos were transferred to recipient mares on Day 8 or Day 3, and conceptuses were recovered 6 or 11 days later. Endo
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Cheeseman, Chris. "Solute carrier family 2, member 9 and uric acid homeostasis." Current Opinion in Nephrology and Hypertension 18, no. 5 (2009): 428–32. http://dx.doi.org/10.1097/mnh.0b013e32832ee3de.

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CHEN, YI-JING, CHIA-HUI LIN, TSAN-TENG OU, et al. "Solute Carrier Family 11 Member A1 Gene Polymorphisms in Reactive Arthritis." Journal of Clinical Immunology 27, no. 1 (2007): 46–52. http://dx.doi.org/10.1007/s10875-006-9050-2.

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Coburn, Lori A., Kshipra Singh, Mohammad Asim, et al. "Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis." Oncogene 38, no. 7 (2018): 1067–79. http://dx.doi.org/10.1038/s41388-018-0492-9.

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Lai, Binbin, Yanli Lai, Yanli Zhang, Miao Zhou, Lixia Sheng, and Guifang OuYang. "The Solute Carrier Family 2 Genes Are Potential Prognostic Biomarkers in Acute Myeloid Leukemia." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303381989430. http://dx.doi.org/10.1177/1533033819894308.

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Aims: The solute carrier family 2 (SLC2) genes are comprised of 14 members which are essential for the maintenance of glucose uptake and survival of tumour cells. This study was performed to investigate the associations of SLC2 family gene expression with mortality in acute myeloid leukemia (AML). Methods: Clinical features and SLC2 family gene expression data were obtained from The Cancer Genome Atlas and Gene Expression Omnibus database. The associations between SLC2 family gene expression and clinicopathologic features were analyzed using linear regression model. Kaplan-Meier survival, univ
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Virkki, Leila V., Jürg Biber, Heini Murer, and Ian C. Forster. "Phosphate transporters: a tale of two solute carrier families." American Journal of Physiology-Renal Physiology 293, no. 3 (2007): F643—F654. http://dx.doi.org/10.1152/ajprenal.00228.2007.

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Phosphate is an essential component of life and must be actively transported into cells against its electrochemical gradient. In vertebrates, two unrelated families of Na+-dependent Pitransporters carry out this task. Remarkably, the two families transport different Pispecies: whereas type II Na+/Picotransporters (SCL34) prefer divalent HPO42−, type III Na+/Picotransporters (SLC20) transport monovalent H2PO4−. The SCL34 family comprises both electrogenic and electroneutral members that are expressed in various epithelia and other polarized cells. Through regulated activity in apical membranes
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Dorwart, Michael R., Nikolay Shcheynikov, Dongki Yang, and Shmuel Muallem. "The Solute Carrier 26 Family of Proteins in Epithelial Ion Transport." Physiology 23, no. 2 (2008): 104–14. http://dx.doi.org/10.1152/physiol.00037.2007.

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Transepithelial Cl− and HCO3− transport is critically important for the function of all epithelia and, when altered or ablated, leads to a number of diseases, including cystic fibrosis, congenital chloride diarrhea, deafness, and hypotension ( 78 , 111 , 119 , 126 ). HCO3− is the biological buffer that maintains acid-base balance, thereby preventing metabolic and respiratory acidosis ( 48 ). HCO3− also buffers the pH of the mucosal layers that line all epithelia, protecting them from injury ( 2 ). Being a chaotropic ion, HCO3− is essential for solubilization of ions and macromolecules such as
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Palmieri, Ferdinando, Pasquale Scarcia, and Magnus Monné. "Diseases Caused by Mutations in Mitochondrial Carrier Genes SLC25: A Review." Biomolecules 10, no. 4 (2020): 655. http://dx.doi.org/10.3390/biom10040655.

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In the 1980s, after the mitochondrial DNA (mtDNA) had been sequenced, several diseases resulting from mtDNA mutations emerged. Later, numerous disorders caused by mutations in the nuclear genes encoding mitochondrial proteins were found. A group of these diseases are due to defects of mitochondrial carriers, a family of proteins named solute carrier family 25 (SLC25), that transport a variety of solutes such as the reagents of ATP synthase (ATP, ADP, and phosphate), tricarboxylic acid cycle intermediates, cofactors, amino acids, and carnitine esters of fatty acids. The disease-causing mutation
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Kim, Yejin, Yu Yeuni, Hye Jin Heo, et al. "Solute carrier family 2 member 2 (glucose transporter 2): a common factor of hepatocyte and hepatocellular carcinoma differentiation." PLOS One 20, no. 4 (2025): e0321020. https://doi.org/10.1371/journal.pone.0321020.

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GLUT2 (SLC2A2), a vital glucose transporter in liver, pancreas, and kidney tissues, regulates blood glucose levels and energy metabolism. Beyond its metabolic role, SLC2A2 contributes to cell differentiation and metabolic adaptation during embryogenesis and tissue regeneration. Despite its significance, the role of SLC2A2 in liver differentiation and hepatocellular carcinoma (HCC) remains underexplored. This study investigated SLC2A2’s role in liver differentiation using in silico, in vitro, and in vivo approaches. Analysis of GEO datasets (GSE132606, GSE25417, GSE67848) and TCGA HCC data reve
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Wang, Zhan, Qingxia Zhao, Yan Nie, et al. "Solute Carrier Family 37 Member 2 (SLC37A2) Negatively Regulates Murine Macrophage Inflammation by Controlling Glycolysis." iScience 23, no. 5 (2020): 101125. http://dx.doi.org/10.1016/j.isci.2020.101125.

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Dissertations / Theses on the topic "Solute carrier family 2"

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Lohi, Hannes. "The human solute carrier 26 family of anion exchangers." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/haart/vk/lohi/.

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Graf, Justin T. "Membrane associated transporter protein gene (SLC45A2) and the genetic basis of normal human pigmentation variation." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/25913/1/Justin_Graf_Thesis.pdf.

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This work is concerned with the genetic basis of normal human pigmentation variation. Specifically, the role of polymorphisms within the solute carrier family 45 member 2 (SLC45A2 or membrane associated transporter protein; MATP) gene were investigated with respect to variation in hair, skin and eye colour ― both between and within populations. SLC45A2 is an important regulator of melanin production and mutations in the gene underly the most recently identified form of oculocutaneous albinism. There is evidence to suggest that non-synonymous polymorphisms in SLC45A2 are associated with normal
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Graf, Justin T. "Membrane associated transporter protein gene (SLC45A2) and the genetic basis of normal human pigmentation variation." Queensland University of Technology, 2008. http://eprints.qut.edu.au/25913/.

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This work is concerned with the genetic basis of normal human pigmentation variation. Specifically, the role of polymorphisms within the solute carrier family 45 member 2 (SLC45A2 or membrane associated transporter protein; MATP) gene were investigated with respect to variation in hair, skin and eye colour ― both between and within populations. SLC45A2 is an important regulator of melanin production and mutations in the gene underly the most recently identified form of oculocutaneous albinism. There is evidence to suggest that non-synonymous polymorphisms in SLC45A2 are associated with normal
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Keathley, Russell Hudson. "Exploring Structure and Function Relationships of the Solute Carrier Protein Family in Disease." Thesis, Icahn School of Medicine at Mount Sinai, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10931576.

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<p> The solute carrier family (&ldquo;SLC&rdquo;) is a diverse group of membrane transporter proteins expressed ubiquitously throughout the human body. SLC members have been heavily implicated in Mendelian disease, and play an active role in the pathogenesis of many cancers. Further, several members of the SLC family have ligands and/or precise functions that have yet to be elucidated. As such, examining the structure and function relationships of this family can have significant implication in the study and drug design of serious disease. We explored these structure and function relationships
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Sibthorpe, Dean. "Molecular evolution of the solute carrier family 11 (SLC11) protein in the Pufferfish, Fugu rubripes." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398868.

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Zaahl, Monique G. (Monique Glenda). "Mutational analysis of the solute carrier family 11 member 1 gene (SLC11A1) implicated in iron transport." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53510.

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Thesis (PhD)--University of Stellenbosch, 2003.<br>ENGLISH ABSTRACT: The solute carrier family 11 member 1 gene (SLC11A 1) is a divalent metal ion transporter with various pleiotropic effects on macrophage function. This gene that regulates iron, and is also regulated by cellular iron levels, has previously been linked to many infectious and autoimmune diseases. In this analysis, in vitro studies using the luciferase reporter system as well as case-control association studies were applied to investigate the significance of SLC11 A1 allelic variation in patients with diverse disease phen
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Bowen, Holly. "Characterisation of the solute carrier family member 11al (Slc11al) promoter : regulation by c-Myc and miz-1." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274540.

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Hellsten, Sofie Victoria. "Characterization of Amino Acid Transporters : Transporters expressed in the central nervous system belonging to the Solute Carrier family SLC38." Doctoral thesis, Uppsala universitet, Institutionen för neurovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-275723.

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In cells and organelles transporters are responsible for translocation of amino acids, sugars and nucleotides among others. In the central nervous system (CNS), amino acid transporters can function as neurotransmitter transporters and nutrient sensors. The Solute carrier (SLC) superfamily is the largest family of transporters with 395 members divided in 52 families. The system A and system N amino acid transporter family, SLC38, consists of 11 members, SNAT1-11 (SLC38A1-11). The members are expressed in the brain, exclusively in neurons or astrocytes and some in both. Amino acid signaling is m
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McManus, Kirk James. "Molecular variation in the solute carrier family 4, anion exchanger member 1 gene, characterization of three low-incidence erythroid antigens." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ51766.pdf.

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柿崎, 文彦. "Caudal-related homeobox(CDX)の新規標的遺伝子 Solute Carrier Family 5, Member 8(SLC5A8)の同定". 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/120360.

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Books on the topic "Solute carrier family 2"

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Servais, Aude, and Bertrand Knebelmann. Cystinuria. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0024.

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Cystinuria (OMIM #220100) is an autosomal recessive disorder of a dibasic amino acid transport in the apical membrane of epithelial cells of the renal proximal tubule and small intestine. It leads to increased urinary cystine excretion and recurrent urolithiasis. The cystine transporter is an heterodimeric transporter which is composed of a heavy subunit, rBAT, linked to a light subunit, b0,+AT. Two genes, SLC3A1 (solute carrier family 3 member 1) and SLC7A9, coding for rBAT and b0,+AT, account for the genetic basis of cystinuria. Cystinuria may lead to obstruction, infections, and ultimately
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Book chapters on the topic "Solute carrier family 2"

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Klingenberg, Martin. "A Mitochondrial Carrier Family for Solute Transport." In Bioenergetics. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5835-0_23.

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Verri, Tiziano, Genciana Terova, Alessandro Romano, et al. "The SoLute Carrier (SLC) Family Series in Teleost Fish." In Functional Genomics in Aquaculture. Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781118350041.ch10.

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Dempsey, Brian R., Anne C. Rintala-Dempsey, Gary S. Shaw, et al. "SLC9A3R1 (Solute Carrier Family 9 Member 3 Regulator 1)." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_101249.

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Ishida, Nobuhiro. "Solute Carrier Family 35 (UDP-Galactose Transporter), Member A2 (SLC35A2)." In Handbook of Glycosyltransferases and Related Genes. Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54240-7_62.

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Nishihara, Shoko. "Solute Carrier Family 35 (CMP-Sialic Acid Transporter), Member A1 (SLC35A1)." In Handbook of Glycosyltransferases and Related Genes. Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54240-7_98.

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Shcheynikov, Nikolay, Ehud Ohana, and Shmuel Muallem. "Properties and Function of the Solute Carrier 26 Family of Anion Transporters." In Ion Channels and Transporters of Epithelia in Health and Disease. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-3366-2_14.

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Baranovski, Boris M., Moran Fremder, and Ehud Ohana. "Properties, Structure, and Function of the Solute Carrier 26 Family of Anion Transporters." In Studies of Epithelial Transporters and Ion Channels. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-55454-5_12.

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Augustin, Robert, and Eric Mayoux. "The Mammalian Solute Carrier Families SLC2 and SLC5: Facilitative and Active Transport of Hexoses and Polyols." In Molecular Life Sciences. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-6436-5_188-2.

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Klussmann, Enno, Eberhard Krause, Burkhard Wiesner, et al. "Cyclic Amp-Mediated Aquaporin-2 Translocation: Identification of Protein Kinase a Anchoring Proteins and the Role of the Small GTPases of the Rho Family." In Molecular Biology and Physiology of Water and Solute Transport. Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-1203-5_20.

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"Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_103600.

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Conference papers on the topic "Solute carrier family 2"

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Chintala, Sreenivasulu, Jianmin Wang, Lei Wei, et al. "Abstract 4300: Solute carrier family group of membrane transporter gene alteration in collecting duct renal cell carcinoma." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-4300.

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Lee, Chansu, Juwon Park, Jeong In Oh, et al. "Abstract 3540: Down-regulation of solute carrier family 17 member 1(SLC17A1) expression contributes to chemotherapy resistance in acute myeloid leukemia." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3540.

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San Jose Martinez, F., Y. A. Pachepsky, and W. J. Rawls. "Solute Transport Simulated With the Fractional Advective-Dispersive Equation." In ASME 2005 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2005. http://dx.doi.org/10.1115/detc2005-84340.

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Solute transport in soils and sediments is commonly simulated with the parabolic advective-dispersive equation, or ADE. Although the solute dispersivity in this equation is regarded as a constant, it has been found to increase with the distance from the solute source. This can be explained assuming the movement of solute particles belongs to the family of Le´vy motions. A one-dimensional solute transport equation was derived for Le´vy motions using fractional derivatives to describe the dispersion. This fractional advective-dispersive equation, or FADE, has two parameters — the fractional disp
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Ahmed, Aqeel, Javier Anez, Stefano Puggelli, Julien Reveillon, Jorge César Brändle de Motta, and François-Xavier Demoulin. "Subgrid Liquid Flux and interface modelling for LES of Atomization." In ILASS2017 - 28th European Conference on Liquid Atomization and Spray Systems. Universitat Politècnica València, 2017. http://dx.doi.org/10.4995/ilass2017.2017.4694.

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Traditional Discrete Particle Methods (DPM) such as the Euler-Lagrange approaches for modelling atomization, even if widely used in technical literature, are not suitable in the near injector region. Indeed, the first step of atomization process is to separate the continuous liquid phase in a set of individual liquid parcels, the so-called primary break-up. Describing two-phase flow by DPM is to define a carrier phase and a discrete phase, hence they cannot be used for primary breakup. On the other hand, full scale simulations (direct simulation of the dynamic DNS, and interface capturing meth
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Yang, Y., MA Becker, and D. Yee. "P2-03-03: An Insulin-Like Growth Factor I (IGF-I)-Induced Gene, Solute Carrier Family 7 Member 11 (SLC7A11)/xCT, Mediates IGF-I-Induced Biological Behaviors in Breast Cancer Cells." In Abstracts: Thirty-Fourth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 6‐10, 2011; San Antonio, TX. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/0008-5472.sabcs11-p2-03-03.

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Moodie, P., I. R. Peake, M. B. Liddell, and A. L. Bloom. "CARRIER DETECTION AND PRENATAL DIAGNOSIS IN HAEMOPHILIA A BY GENE ANALYSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644007.

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Restriction fragment length polymorphism (RFLP) analysis has been used to perform family studies, including prenatal diagnosis, in 21 haemophilia A kindred.Two intragenomic RFLPs were studied in conjunction with one linked RFLP. The intragenomic BgII RFLP,situation 3' to exon 26 was detected with cDNA probe C (Genetics Institute) giving bands of 20kb (17% of X chromosomes) and 5kb (83%), and the intragenomic Bell RFLP, situated 3' to exon 18, was detected with the genomic DNA probe pi 14.12 from Genentech. The frequency of this RFLP in the local population was 23% (1.1 kb allele) and 77% (0.88
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Kojima, T., M. Tanimoto, T. Kamiya, Y. Obata, K. Kurachi, and H. Saito. "ANALYSIS OF FACTOR IX GENE IN NORMAL SUBJECTS AND HEMOPHILIA B PATIENTS IN JAPAN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644077.

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We have examined DNA samples from 25 hemophilia B patients (21 B- patients, 2 BR patients and 2 B+ patients) and 51 normal subjects with molecular probes (pHFIX and 2 genomic fragments). By structural gene analysis, 4 out of 7 patients who developed anti-factor IX antibodies were detected to have gross factor IX gene deletion. Although these four patients showed normal pattern of HPRT gene detected by pCDHPRT, the gene deletions were found to expand more than 34kb including with entire factor IX exons. Quantitative Southern blot analysis of factor IX gene of the patient's family members indica
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Lee, Chi H., Aileen M. Yurek, M. G. Li, E. Chauchard, and R. Fischers. "Optoelectronic Modulation of Millimeter-Waves in a Silicon-on-Sapphire Waveguide." In Picosecond Electronics and Optoelectronics. Optica Publishing Group, 1985. http://dx.doi.org/10.1364/peo.1985.we4.

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Optically controlled millimeter-wave devices such as IMPATT(1) and TRAPATT(2) diode have been reported. Millimeter-wave phase shifter utilizing an electronically injected electron-hole plasma in a semiconductor waveguide has also been demonstrated.(3) None of these devices, however, can operate at high speed. In our laboratory, we have developed a family of optoelectronic devices at the millimeter-wave spectral region which have picosecond speed capability.(4,5) For example, the gating of millimeter-wave pulse with vasriable pulse duration ranging from a few nanoseconds to subnanoseconds has b
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Youssoufiän, H., A. Patel, D. Phillips, H. H. Kazazian, and S. E. Antonarakis. "RECURRENT MUTATIONS AND AN UNUSUAL DELETION IN HEMOPHILIA A." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644014.

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We have identified 15 mutations of the factor VIII (F8) gene from a panel of 107 patients with hemophilia A and have characterized these gene defects byrestriction analysis, oligonucleotide hybridization, cloning and DNA sequencing. Recurrent point mutations that involve CG to TG transitions were identified in exon 18, exon 22, and exon 24; a single CG to TG transition was identified in exon 23; and a CG to CA transition was identified in exon 24. In addition, a Taq I site alteration in intron 4 was identified in a patient with mild hemophilia, which arose dg. S23&amp;in a grandpaternal germ c
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Ellington, Louis, Glenn McAndrews, Alexander Harsema-Mensonides, and Ravi Tanwar. "Gas Turbine Propulsion for LNG Transports." In ASME Turbo Expo 2006: Power for Land, Sea, and Air. ASMEDC, 2006. http://dx.doi.org/10.1115/gt2006-90715.

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GE aero-derivative gas turbines were first introduced into marine operations during the late 1960’s and early 1970’s. GE is now leveraging its many years of proven marine experience and offshore dual-fuel experience to offer dual-fuel gas turbines for LNG Carrier (LNGC) propulsion and electric power. With building of new larger LNGC’s now beginning, the industry is seriously considering a change to gas turbine based systems in order to capitalize on their many advantages. CoGES (combined gas turbine — steam generator electric) plants for LNGC’s consist of dual-fueled gas-turbine-generator (GTG
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Reports on the topic "Solute carrier family 2"

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Malkinson, Mertyn, Irit Davidson, Moshe Kotler, and Richard L. Witter. Epidemiology of Avian Leukosis Virus-subtype J Infection in Broiler Breeder Flocks of Poultry and its Eradication from Pedigree Breeding Stock. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7586459.bard.

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Objectives 1. Establish diagnostic procedures to identify tolerant carrier birds based on a) Isolation of ALV-J from blood, b) Detection of group-specific antigen in cloacal swabs and egg albumen. Application of these procedures to broiler breeder flocks with the purpose of removing virus positive birds from the breeding program. 2. Survey the AL V-J infection status of foundation lines to estimate the feasibility of the eradication program 3. Investigate virus transmission through the embryonated egg (vertical) and between chicks in the early post-hatch period (horizontal). Establish a model
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