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Journal articles on the topic 'Solute carrier family 2'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Gibson, Charlotte, Marta de Ruijter-Villani, Jolanda Rietveld, and Tom A. E. Stout. "Amino acid transporter expression in the endometrium and conceptus membranes during early equine pregnancy." Reproduction, Fertility and Development 30, no. 12 (2018): 1675. http://dx.doi.org/10.1071/rd17352.

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Maternally derived amino acids (AA) are essential for early conceptus development, and specific transporters enhance histotrophic AA content during early ruminant pregnancy. In the present study we investigated AA transporter expression in early equine conceptuses and endometrium, during normal pregnancy and after induction of embryo–uterus asynchrony. ‘Normal’ conceptuses and endometrium were recovered on Days 7, 14, 21 and 28 after ovulation. To investigate asynchrony, Day 8 embryos were transferred to recipient mares on Day 8 or Day 3, and conceptuses were recovered 6 or 11 days later. Endo

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2

Cheeseman, Chris. "Solute carrier family 2, member 9 and uric acid homeostasis." Current Opinion in Nephrology and Hypertension 18, no. 5 (2009): 428–32. http://dx.doi.org/10.1097/mnh.0b013e32832ee3de.

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3

CHEN, YI-JING, CHIA-HUI LIN, TSAN-TENG OU, et al. "Solute Carrier Family 11 Member A1 Gene Polymorphisms in Reactive Arthritis." Journal of Clinical Immunology 27, no. 1 (2007): 46–52. http://dx.doi.org/10.1007/s10875-006-9050-2.

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4

Coburn, Lori A., Kshipra Singh, Mohammad Asim, et al. "Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis." Oncogene 38, no. 7 (2018): 1067–79. http://dx.doi.org/10.1038/s41388-018-0492-9.

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Lai, Binbin, Yanli Lai, Yanli Zhang, Miao Zhou, Lixia Sheng, and Guifang OuYang. "The Solute Carrier Family 2 Genes Are Potential Prognostic Biomarkers in Acute Myeloid Leukemia." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303381989430. http://dx.doi.org/10.1177/1533033819894308.

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Aims: The solute carrier family 2 (SLC2) genes are comprised of 14 members which are essential for the maintenance of glucose uptake and survival of tumour cells. This study was performed to investigate the associations of SLC2 family gene expression with mortality in acute myeloid leukemia (AML). Methods: Clinical features and SLC2 family gene expression data were obtained from The Cancer Genome Atlas and Gene Expression Omnibus database. The associations between SLC2 family gene expression and clinicopathologic features were analyzed using linear regression model. Kaplan-Meier survival, univ

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Virkki, Leila V., Jürg Biber, Heini Murer, and Ian C. Forster. "Phosphate transporters: a tale of two solute carrier families." American Journal of Physiology-Renal Physiology 293, no. 3 (2007): F643—F654. http://dx.doi.org/10.1152/ajprenal.00228.2007.

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Phosphate is an essential component of life and must be actively transported into cells against its electrochemical gradient. In vertebrates, two unrelated families of Na+-dependent Pitransporters carry out this task. Remarkably, the two families transport different Pispecies: whereas type II Na+/Picotransporters (SCL34) prefer divalent HPO42−, type III Na+/Picotransporters (SLC20) transport monovalent H2PO4−. The SCL34 family comprises both electrogenic and electroneutral members that are expressed in various epithelia and other polarized cells. Through regulated activity in apical membranes

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Dorwart, Michael R., Nikolay Shcheynikov, Dongki Yang, and Shmuel Muallem. "The Solute Carrier 26 Family of Proteins in Epithelial Ion Transport." Physiology 23, no. 2 (2008): 104–14. http://dx.doi.org/10.1152/physiol.00037.2007.

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Transepithelial Cl− and HCO3− transport is critically important for the function of all epithelia and, when altered or ablated, leads to a number of diseases, including cystic fibrosis, congenital chloride diarrhea, deafness, and hypotension ( 78 , 111 , 119 , 126 ). HCO3− is the biological buffer that maintains acid-base balance, thereby preventing metabolic and respiratory acidosis ( 48 ). HCO3− also buffers the pH of the mucosal layers that line all epithelia, protecting them from injury ( 2 ). Being a chaotropic ion, HCO3− is essential for solubilization of ions and macromolecules such as

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Palmieri, Ferdinando, Pasquale Scarcia, and Magnus Monné. "Diseases Caused by Mutations in Mitochondrial Carrier Genes SLC25: A Review." Biomolecules 10, no. 4 (2020): 655. http://dx.doi.org/10.3390/biom10040655.

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In the 1980s, after the mitochondrial DNA (mtDNA) had been sequenced, several diseases resulting from mtDNA mutations emerged. Later, numerous disorders caused by mutations in the nuclear genes encoding mitochondrial proteins were found. A group of these diseases are due to defects of mitochondrial carriers, a family of proteins named solute carrier family 25 (SLC25), that transport a variety of solutes such as the reagents of ATP synthase (ATP, ADP, and phosphate), tricarboxylic acid cycle intermediates, cofactors, amino acids, and carnitine esters of fatty acids. The disease-causing mutation

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9

Kim, Yejin, Yu Yeuni, Hye Jin Heo, et al. "Solute carrier family 2 member 2 (glucose transporter 2): a common factor of hepatocyte and hepatocellular carcinoma differentiation." PLOS One 20, no. 4 (2025): e0321020. https://doi.org/10.1371/journal.pone.0321020.

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GLUT2 (SLC2A2), a vital glucose transporter in liver, pancreas, and kidney tissues, regulates blood glucose levels and energy metabolism. Beyond its metabolic role, SLC2A2 contributes to cell differentiation and metabolic adaptation during embryogenesis and tissue regeneration. Despite its significance, the role of SLC2A2 in liver differentiation and hepatocellular carcinoma (HCC) remains underexplored. This study investigated SLC2A2’s role in liver differentiation using in silico, in vitro, and in vivo approaches. Analysis of GEO datasets (GSE132606, GSE25417, GSE67848) and TCGA HCC data reve

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Wang, Zhan, Qingxia Zhao, Yan Nie, et al. "Solute Carrier Family 37 Member 2 (SLC37A2) Negatively Regulates Murine Macrophage Inflammation by Controlling Glycolysis." iScience 23, no. 5 (2020): 101125. http://dx.doi.org/10.1016/j.isci.2020.101125.

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11

Vazquez-Chantada, Mercedes, Aintzane Gonzalez-Lahera, Ibon Martinez-Arranz, et al. "Solute carrier family 2 member 1is involved in the development of nonalcoholic fatty liver disease." Hepatology 57, no. 2 (2012): 505–14. http://dx.doi.org/10.1002/hep.26052.

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12

Vazquez-Chantada, Mercedes, Aintzane Gonzalez-Lahera, Ibon Martinez-Arranz, et al. "Solute Carrier Family 2 Member1 Is Involved in the Development of Nonalcoholic Fatty Liver Disease." Hepatology 57, no. 2 (2012): 505–14. https://doi.org/10.1002/hep.26052.

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Abstract Susceptibility to develop nonalcoholic fatty liver disease (NAFLD) has genetic bases, but the associated variants are uncertain. The aim of the present study was to identify genetic variants that could help to prognose and further understand the genetics and development of NAFLD. Allele frequencies of 3,072 single-nucleotide polymorphisms (SNPs) in 92 genes were characterized in 69 NAFLD patients and 217 healthy individuals. The markers that showed significant allele-frequency differences in the pilot groups were subsequently studied in 451 NAFLD patients and 304 healthy controls. Bes

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Araújo, Ananda de Mesquita, and Sandra Fernandes Arruda. "Ameliorating the impairment of glucose utilization in a high-fat diet-induced obesity model through the consumption of Tucum-do-Cerrado (Bactris Setosa Mart.)." PLOS ONE 19, no. 1 (2024): e0293627. http://dx.doi.org/10.1371/journal.pone.0293627.

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Introduction We evaluated the effect of Tucum-do-Cerrado on glucose metabolism homeostasis and its relationship with redox-inflammatory responses in a high-fat (HF) diet-induced obesity model. Results The HF diet increased energy intake, feed efficiency, body weight, muscle and hepatic glycogen, insulin, homeostatic model assessment of insulin resistance (HOMA IR) and beta (β)-cell function, and gut catalase (CAT) activity, and decreased food intake, hepatic glutathione reductase (GR), glutathione peroxidase (GPX), glutathione S-transferase (GST), and superoxide dismutase (SOD) activities, hep

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Peng, Qing, Li-Yuan Hao, Ying-Lin Guo, et al. "Solute carrier family 2 members 1 and 2 as prognostic biomarkers in hepatocellular carcinoma associated with immune infiltration." World Journal of Clinical Cases 10, no. 13 (2022): 3989–4019. http://dx.doi.org/10.12998/wjcc.v10.i13.3989.

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Ozbayer, Cansu, Hulyam Kurt, Medine Nur Kebapci, Hasan Veysi Gunes, Ertugrul Colak, and Irfan Degirmenci. "The genetic variants of solute carrier family 11 member 2 gene and risk of developing type-2 diabetes." Journal of Genetics 97, no. 5 (2018): 1407–12. http://dx.doi.org/10.1007/s12041-018-1032-7.

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Seyer, Pascal, Franck Vandermoere, Elisabeth Cassier, Joël Bockaert, and Philippe Marin. "Physical and functional interactions between the serotonin transporter and the neutral amino acid transporter ASCT2." Biochemical Journal 473, no. 13 (2016): 1953–65. http://dx.doi.org/10.1042/bcj20160315.

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The activity of serotonergic systems depends on the reuptake of extracellular serotonin via its plasma membrane serotonin [5-HT (5-hydroxytryptamine)] transporter (SERT), a member of the Na+/Cl−-dependent solute carrier 6 family. SERT is finely regulated by multiple molecular mechanisms including its physical interaction with intracellular proteins. The majority of previously identified SERT partners that control its functional activity are soluble proteins, which bind to its intracellular domains. SERT also interacts with transmembrane proteins, but its association with other plasma membrane

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Wang, Bin, Lili Jiang, Zhenlong Wu, and Zhaolai Dai. "L-Tryptophan Differentially Regulated Glucose and Amino Acid Transporters in the Small Intestine of Rat Challenged with Lipopolysaccharide." Animals 12, no. 21 (2022): 3045. http://dx.doi.org/10.3390/ani12213045.

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Tryptophan (Trp) has been shown to improve the growth and gut function of weaned piglets. Whether the growth-promoting effect of Trp is due to the improvement in nutrient transport and absorption during weaning or under conditions of inflammation has not been fully characterized. The objective of this study was to determine the effects of Trp on lipopolysaccharide (LPS)-induced changes in glucose and amino acid (AA) transport in the rat jejunum. Twenty-four 7-week-old Sprague Dawley rats were randomly divided into one of three groups: control, LPS, and Trp + LPS. Rats were supplemented with 0

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Qi, Zhirui, Yunfei Pu, Haiyang Guo, Wenwu Tang, Yilin Xiong, and Boli Ran. "Identification and subtype analysis of biomarkers associated with the solute carrier family in acute myocardial infarction." Medicine 102, no. 49 (2023): e36515. http://dx.doi.org/10.1097/md.0000000000036515.

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The dysregulation of some solute carrier (SLC) proteins has been linked to a variety of diseases, including diabetes and chronic kidney disease. However, SLC-related genes (SLCs) has not been extensively studied in acute myocardial infarction (AMI). The GSE66360 and GSE60993 datasets, and SLCs geneset were enrolled in this study. Differentially expressed SLCs (DE-SLCs) were screened by overlapping DEGs between the AMI and control groups and SLCs. Next, functional enrichment analysis was carried out to research the function of DE-SLCs. Consistent clustering of samples from the GSE66360 dataset

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Han, Rui, Wei Sun, and Hao Zhang. "Identification of a Signature Comprising 5 Soluble Carrier Family Genes to Predict the Recurrence of Papillary Thyroid Carcinoma." Technology in Cancer Research & Treatment 20 (January 1, 2021): 153303382110363. http://dx.doi.org/10.1177/15330338211036314.

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RNA-sequencing data and relevant clinical data in The Cancer Genome Atlas for 502 samples of papillary thyroid cancer (PTC) were analyzed to determine the prognostic value of soluble carrier family genes in PTC. We analyzed soluble carrier family gene expression and function in the samples. Clustering identified 2 clusters in the data. Risk characteristics were identified using LASSO and Univariate Cox regression analysis, which divided the patients into low and high-risk groups. The expression levels of 88 soluble carrier genes were significantly different between tumors and normal tissue. Th

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Jakoby, Michael, Amruta Jaju, Aundrea Marsh, and Andrew Wilber. "Maternal Primary Carnitine Deficiency and a Novel Solute Carrier Family 22 Member 5 (SLC22A5) Mutation." Journal of Investigative Medicine High Impact Case Reports 9 (January 2021): 232470962110195. http://dx.doi.org/10.1177/23247096211019543.

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Primary carnitine deficiency (PCD) is a rare autosomal recessive disorder caused by loss of function mutations in the solute carrier family 22 member 5 ( SLC22A5) gene that encodes a high-affinity sodium-ion–dependent organic cation transporter protein (OCTN2). Reduced carnitine transport results in diminished fatty acid oxidation in heart and skeletal muscle and carnitine wasting in urine. We present a case of PCD diagnosed in an adult female after a positive newborn screen (NBS) for PCD that was not confirmed on follow-up testing. The mother was referred for evaluation of persistent fatigue

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Zhang, Boru, Wei Yang, Hongyun Zhang, et al. "Effect of pyrroloquinoline quinone disodium in female rats during gestating and lactating on reproductive performance and the intestinal barrier functions in the progeny." British Journal of Nutrition 121, no. 7 (2019): 818–30. http://dx.doi.org/10.1017/s0007114519000047.

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AbstractThe objective of this study was to investigate the effects of dietary pyrroloquinoline quinone disodium (PQQ·Na2) supplementation on the reproductive performance and intestinal barrier functions of gestating and lactating female Sprague–Dawley (SD) rats and their offspring. Dietary supplementation with PQQ·Na2increased the number of implanted embryos per litter during gestation and lactation at GD 20 and increased the number of viable fetuses per litter, and the weight of uterine horns with fetuses increased at 1 d of newborn. The mRNA expression levels of catalase (CAT), glutathione p

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Hwang, Yun Su, and Eungseok Oh. "Solute Carrier Family 2 Member 1 Gene Mutation Presenting as Adult-Onset Paroxysmal Exercise-Induced Dyskinesia Without Epilepsy." Journal of Clinical Neurology 20, no. 6 (2024): 627. http://dx.doi.org/10.3988/jcn.2024.0349.

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23

Singh, Kshipra, Nicole T. Al-Greene, Thomas G. Verriere, et al. "The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria." PLOS Pathogens 12, no. 10 (2016): e1005984. http://dx.doi.org/10.1371/journal.ppat.1005984.

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24

Liu, Liguo, Yi Yang, Xueming Zhou, Xuebing Yan, and Zhenqian Wu. "Solute carrier family 34 member 2 overexpression contributes to tumor growth and poor patient survival in colorectal cancer." Biomedicine & Pharmacotherapy 99 (March 2018): 645–54. http://dx.doi.org/10.1016/j.biopha.2018.01.124.

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25

Huang, Xiaoyan, Junchen Chen, Weiqi Zeng, Xiang Wu, Mingliang Chen, and Xiang Chen. "Membrane-enriched solute carrier family 2 member 1 (SLC2A1/GLUT1) in psoriatic keratinocytes confers sensitivity to 2-deoxy-D-glucose (2-DG) treatment." Experimental Dermatology 28, no. 2 (2018): 198–201. http://dx.doi.org/10.1111/exd.13850.

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26

Jha, Prabhash, Anita Sahu, Amit Prabhakar, et al. "Genome-Wide Expression Analysis Suggests Hypoxia-Triggered Hyper-Coagulation Leading to Venous Thrombosis at High Altitude." Thrombosis and Haemostasis 118, no. 07 (2018): 1279–95. http://dx.doi.org/10.1055/s-0038-1657770.

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AbstractVenous thromboembolism (VTE), a multi-factorial disease, is the third most common cardiovascular disease. Established genetic and acquired risk factors are responsible for the onset of VTE. High altitude (HA) also poses as an additional risk factor, predisposing individuals to VTE; however, its molecular mechanism remains elusive. This study aimed to identify genes/pathways associated with the pathophysiology of deep vein thrombosis (DVT) at HA. Gene expression profiling of DVT patients, who developed the disease, either at sea level or at HA-DVT locations, resulted in differential exp

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Hoffman, Nicholas E., Harish C. Chandramoorthy, Santhanam Shanmughapriya, et al. "SLC25A23 augments mitochondrial Ca2+ uptake, interacts with MCU, and induces oxidative stress–mediated cell death." Molecular Biology of the Cell 25, no. 6 (2014): 936–47. http://dx.doi.org/10.1091/mbc.e13-08-0502.

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Emerging findings suggest that two lineages of mitochondrial Ca2+ uptake participate during active and resting states: 1) the major eukaryotic membrane potential–dependent mitochondrial Ca2+ uniporter and 2) the evolutionarily conserved exchangers and solute carriers, which are also involved in ion transport. Although the influx of Ca2+ across the inner mitochondrial membrane maintains metabolic functions and cell death signal transduction, the mechanisms that regulate mitochondrial Ca2+ accumulation are unclear. Solute carriers—solute carrier 25A23 (SLC25A23), SLC25A24, and SLC25A25—represent

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Shi, Zhenyu, Jiahao Liu, Fei Wang, and Yongqiang Li. "Integrated analysis of Solute carrier family-2 members reveals SLC2A4 as an independent favorable prognostic biomarker for breast cancer." Channels 15, no. 1 (2021): 555–68. http://dx.doi.org/10.1080/19336950.2021.1973788.

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Abrahams-October, Zainonesa, Yunus Kippie, Keenau Pearce, Rabia Johnson, and Mongi Benjeddou. "Effects of Xhosa specific solute carrier family 22-member 2 haplotypes on the cellular uptake of metformin and cimetidine." Gene 937 (February 2025): 149157. https://doi.org/10.1016/j.gene.2024.149157.

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Jamieson, Sarra E., Jacqueline K. White, Joanna M. M. Howson, et al. "Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer's disease." Neuroscience Letters 374, no. 2 (2005): 124–28. http://dx.doi.org/10.1016/j.neulet.2004.10.038.

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Nishida, Yuichiro, Mayumi Yoshioka, and Jonny St-Amand. "Regulation of hypothalamic gene expression by glucocorticoid: implications for energy homeostasis." Physiological Genomics 25, no. 1 (2006): 96–104. http://dx.doi.org/10.1152/physiolgenomics.00232.2005.

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The present study investigated the hypothalamic gene expressions regulated by glucocorticoids (GC), key hormones in energy homeostasis. Using the serial analysis of gene expression (SAGE) method, we studied the effects of adrenalectomy (ADX) and GC on the transcriptomes of mouse hypothalamus. Approximately 180,000 SAGE tags, which correspond to 50,000 tag species, were isolated from each group of intact or adrenalectomized mice as well as 1, 3, and 24 h after GC injection. ADX upregulated diazepam binding inhibitor gene expression while downregulating vomeronasal 1 receptor D4, genes involved

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Muthusamy, Ganesan, Chin-Chi Liu, and Andrea N. Johnston. "Deletion of PGAM5 Downregulates FABP1 and Attenuates Long-Chain Fatty Acid Uptake in Hepatocellular Carcinoma." Cancers 15, no. 19 (2023): 4796. http://dx.doi.org/10.3390/cancers15194796.

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Phosphoglycerate mutase 5 (PGAM5) is a Ser/His/Thr phosphatase responsible for regulating mitochondrial homeostasis. Overexpression of PGAM5 is correlated with a poor prognosis in hepatocellular carcinoma, colon cancer, and melanoma. In hepatocellular carcinoma, silencing of PGAM5 reduces growth, which has been attributed to decreased mitophagy and enhanced apoptosis. Yet in colon cancer, PGAM5’s pro-tumor survival effect is correlated to lipid metabolism. We sought to identify whether deletion of PGAM5 modulated lipid droplet accrual in hepatocellular carcinoma. HepG2 and Huh7 PGAM5 knockout

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Tebeka, Nchimunya Nelisa, Stephen Atkinson, Luke D. Tyson, et al. "Loss of solute carrier family 38 member 4 (SLC38A4) as a driver for the pathogenesis of severe alcoholic hepatitis." Journal of Hepatology 77 (July 2022): S140—S141. http://dx.doi.org/10.1016/s0168-8278(22)00660-2.

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Karambataki, Maria, Andigoni Malousi, Georgios Tzimagiorgis, et al. "Association of two synonymous splicing-associated CpG single nucleotide polymorphisms in calpain 10 and solute carrier family 2 member 2 with type 2 diabetes." Biomedical Reports 6, no. 2 (2016): 146–58. http://dx.doi.org/10.3892/br.2016.833.

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González-Fernández, L., M. J. Sánchez-Calabuig, M. G. Alves, et al. "Expanded equine cumulus–oocyte complexes exhibit higher meiotic competence and lower glucose consumption than compact cumulus–oocyte complexes." Reproduction, Fertility and Development 30, no. 2 (2018): 297. http://dx.doi.org/10.1071/rd16441.

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Equine cumulus–oocyte complexes (COCs) are classified as compact (cCOC) or expanded (eCOC) and vary in their meiotic competence. This difference could be related to divergent glucose metabolism. To test this hypothesis in the present study, eCOCs, cCOCs and expanded or compact mural granulosa cells (EC and CC respectively) were matured in vitro for 30 h, at which time maturation rate, glucose metabolism and the expression of genes involved in glucose transport, glycolysis, apoptosis and meiotic competence were determined. There were significant differences between eCOCs and cCOCs in maturation

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Zhao, Di-Cheng, Yu-Mei Li, Jie-Liang Ma, et al. "Single-cell RNA sequencing reveals distinct gene expression patterns in glucose metabolism of human preimplantation embryos." Reproduction, Fertility and Development 31, no. 2 (2019): 237. http://dx.doi.org/10.1071/rd18178.

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Precise regulation of glucose metabolism-related genes is essential for early embryonic development. Although previous research has yielded detailed information on the biochemical processes, little is yet known of the dynamic gene expression profiles in glucose metabolism of preimplantation embryos at a single-cell resolution. In the present study, we performed integrated analysis of single-cell RNA sequencing (scRNA-seq) data of human preimplantation embryos that had been cultured in sequential medium. Different cells in the same embryo have similar gene expression patterns in glucose metabol

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Zhang, Lei, Wen Liu, Fangyan Liu, et al. "IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer." Oxidative Medicine and Cellular Longevity 2020 (April 4, 2020): 1–14. http://dx.doi.org/10.1155/2020/1675613.

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Ferroptosis, implicated in several diseases, is a new form of programmed and nonapoptotic cell death triggered by iron-dependent lipid peroxidation after inactivation of the cystine/glutamate antiporter system xc–, which is composed of solute carrier family 7 membrane 11 (SLC7A11) and solute carrier family 3 membrane 2 (SLC3A2). Therefore, inducing ferroptosis through inhibiting the cystine/glutamate antiporter system xc– may be an effective way to treat cancer. In previous screening tests, we found that the benzopyran derivative 2-imino-6-methoxy-2H-chromene-3-carbothioamide (IMCA) significan

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Salemi, Michele, Maria Ravo, Giuseppe Lanza, et al. "Gene Expression Profiling of Post Mortem Midbrain of Parkinson’s Disease Patients and Healthy Controls." International Journal of Molecular Sciences 25, no. 2 (2024): 707. http://dx.doi.org/10.3390/ijms25020707.

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Parkinson’s disease (PD) stands as the most prevalent degenerative movement disorder, marked by the degeneration of dopaminergic neurons in the substantia nigra of the midbrain. In this study, we conducted a transcriptome analysis utilizing post mortem mRNA extracted from the substantia nigra of both PD patients and healthy control (CTRL) individuals. Specifically, we acquired eight samples from individuals with PD and six samples from CTRL individuals, with no discernible pathology detected in the latter group. RNA sequencing was conducted using the TapeStation 4200 system from Agilent Techno

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Hakim, Sarah Adel, Rasha Mohamed Abd El Atti, Reham Mohamed Faheim, and Hoda Hassan Abou Gabal. "Evaluation of the Prognostic Value of Solute Carrier Family 34 Member 2 “SLC34A2” in Papillary Thyroid Carcinoma: An Immunohistochemical Study." Analytical Cellular Pathology 2021 (July 14, 2021): 1–10. http://dx.doi.org/10.1155/2021/3198555.

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Background. Papillary thyroid carcinoma (PTC) usually has an indolent clinical course, yet a subset of patients might show an aggressive course. Thus, better stratification of at-risk patients is mandatory for proper management. Solute carrier family 34 member 2 (SLC34A2) is an independent prognostic indicator in several cancers. However, only a few studies have been conducted to evaluate the prognostic value of SLC34A2 in PTC, with none of them assessing its immunohistochemical (IHC) expression in a large cohort of patients with PTC or exploring its possible relationship with tumor progressio

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Tiwari, Anoop Kumar, Devansh Jain, Sheikh Nizamuddin, et al. "Solute carrier family 2 members (SLC2A) as potential targets for the treatment of head and neck squamous cell carcinoma patients." Human Gene 43 (February 2025): 201365. http://dx.doi.org/10.1016/j.humgen.2024.201365.

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Balázs, A., T. Rubil, G. Harnisch, W. Namkung, and M. Mall. "191 Inflammation induces solute carrier family 26 member 9–mediated chloride secretion in healthy but not cystic fibrosis airway epithelium." Journal of Cystic Fibrosis 23 (September 2024): S106—S107. http://dx.doi.org/10.1016/s1569-1993(24)01031-2.

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Salisbury, Carlee M., Abbey R. Rathert, and Andrew P. Foote. "Effect of Increased Ruminal Propionate on the Expression of Gluconeogenic Genes in the Liver of Cattle on a Finishing Diet." Journal of Animal Science 99, Supplement_2 (2021): 46. http://dx.doi.org/10.1093/jas/skab096.085.

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Abstract The objective of this experiment was to determine whether increasing ruminal propionate in various amounts will lead to an increased expression of genes in the liver related to glucose metabolism. Holstein (n = 15) steers were individually fed a finishing diet ad libitum, twice a day, with free access to water. Treatments consisted of no added calcium propionate (CON), 100 g/d (LOW), or 300 g/d (HIGH). Treatments were split in half and mixed in the diet twice daily. Liver biopsies were taken on day 33 of propionate treatment and immediately frozen on dry ice. Samples were extracted fo

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Fafutis-Morris, Mary, AnaLaura Pereira-Suárez, Anabell Alvarado-Navarro, JuanGabriel Barrietos-García, Ciro Estrada-Chávez, and JoséFrancisco Muñoz-Valle. "Differential expression of solute carrier family 11a member 1 and inducible nitric oxide synthase 2 in skin biopsies from leprosy patients." Indian Journal of Dermatology, Venereology, and Leprology 81, no. 6 (2015): 594. http://dx.doi.org/10.4103/0378-6323.168345.

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Wang, Guoyan, Senlin Qin, Yining Zheng, et al. "T-2 Toxin Induces Ferroptosis by Increasing Lipid Reactive Oxygen Species (ROS) and Downregulating Solute Carrier Family 7 Member 11 (SLC7A11)." Journal of Agricultural and Food Chemistry 69, no. 51 (2021): 15716–27. http://dx.doi.org/10.1021/acs.jafc.1c05393.

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Takesono, A., J. Moger, S. Farooq, et al. "Solute carrier family 3 member 2 (Slc3a2) controls yolk syncytial layer (YSL) formation by regulating microtubule networks in the zebrafish embryo." Proceedings of the National Academy of Sciences 109, no. 9 (2012): 3371–76. http://dx.doi.org/10.1073/pnas.1200642109.

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Sahni, Jaya, Bruce Nelson, and Andrew M. Scharenberg. "SLC41A2 encodes a plasma-membrane Mg2+ transporter." Biochemical Journal 401, no. 2 (2006): 505–13. http://dx.doi.org/10.1042/bj20060673.

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The TRPM7 (transient receptor potential melastatin 7) ion channel has been implicated in the uptake of Mg2+ into vertebrate cells, as elimination of TRPM7 expression through gene targeting in DT40 B-lymphocytes renders them unable to grow in the absence of supplemental Mg2+. However, a residual capacity of TRPM7-deficient cells to accumulate Mg2+ and proliferate when provided with supplemental Mg2+ suggests the existence of Mg2+ uptake mechanism(s) other than TRPM7. Evaluation of the expression of several members of the SLC41 (solute carrier family 41) family, which exhibit homology with the M

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Ta, Hoang Dang Khoa, Do Thi Minh Xuan, Wan-Chun Tang, et al. "Novel Insights into the Prognosis and Immunological Value of the SLC35A (Solute Carrier 35A) Family Genes in Human Breast Cancer." Biomedicines 9, no. 12 (2021): 1804. http://dx.doi.org/10.3390/biomedicines9121804.

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According to statistics 2020, female breast cancer (BRCA) became the most commonly diagnosed malignancy worldwide. Prognosis of BRCA patients is still poor, especially in population with advanced or metastatic. Particular functions of each members of the solute carrier 35A (SLC35A) gene family in human BRCA are still unknown regardless of awareness that they play critical roles in tumorigenesis and progression. Using integrated bioinformatics analyses to identify therapeutic targets for specific cancers based on transcriptomics, proteomics, and high-throughput sequencing, we obtained new infor

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Komaniecka, Nina, Sonia Maroszek, Maria Drozdzik, Stefan Oswald, and Marek Drozdzik. "Transporter Proteins as Therapeutic Drug Targets—With a Focus on SGLT2 Inhibitors." International Journal of Molecular Sciences 25, no. 13 (2024): 6926. http://dx.doi.org/10.3390/ijms25136926.

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Membrane transporters interact not only with endogenous substrates but are also engaged in the transport of xenobiotics, including drugs. While the coordinated function of uptake (solute carrier family—SLC and SLCO) and efflux (ATP-binding cassette family—ABC, multidrug and toxic compound extrusion family—MATE) transporter system allows vectorial drug transport, efflux carriers alone achieve barrier functions. The modulation of transport functions was proved to be effective in the treatment strategies of various pathological states. Sodium–glucose cotransporter-2 (SGLT2) inhibitors are the dru

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McConnell, Hunter L., Abigail R. Rathert, and Andrew P. Foote. "PSII-4 Effect of increased ruminal propionate on the expression of hepatic gluconeogenic genes in cattle on a finishing ration." Journal of Animal Science 99, Supplement_3 (2021): 314. http://dx.doi.org/10.1093/jas/skab235.577.

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Abstract The objective of this experiment was to ascertain if supplementing calcium propionate (CaP) in varying amounts would result in the increased expression of genes related to glucose metabolism in the liver. The study utilized cannulated Holstein steers (n = 6) in a 3 × 6 Latin rectangle with three 15-d periods. The treatments were as follows: Control (no CaP), low propionate (100 g/d CaP), and high propionate (300 g/d CaP). The treatments were administered in halves twice a day through rumen cannulas. The steers were provided with ad libitum finishing ration, using Insentec feeders to r

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Miah, Quddus, Kanij Fatema, Farah Naz Dola, and Kazi Ashraful Islam. "Fanconi-Bickel Syndrome: A Rare Etiology of Hypophosphatemic Rickets." Paediatric Nephrology Journal of Bangladesh 9, no. 1 (2024): 39–42. http://dx.doi.org/10.4103/pnjb.pnjb_11_23.

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Fanconi-Bickel syndrome (FBS) is a rare type of glycogen storage disease (GSD). Usual presentations of this condition are hepatomegaly, nephropathy, postprandial hyperglycemia, fasting hypoglycemia, developmental delay and growth retardation. An investigation shows rachitic changes with calcinuria, phosphaturia, glycosuria, and metabolic acidosis. Liver biopsy shows features of GSD and whole exome sequencing shows solute carrier family 2, facilitated glucose transporter member 1 gene mutation which encodes glucose transporter (GLUT2). In this study, we present the case of a child who had prese

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