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Journal articles on the topic 'Solvent evaporation method'

Author: Grafiati

Published: 3 June 2025

Last updated: 1 August 2025

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1

Qader, Hemn, Hewa Hamadameen, and Anjam Abdullah. "Improvement of solubility and dissolution rate of Biopharmaceutical Class II drug atorvastatin calcium by using an essential amino acid L-leucine." Zanco Journal of Medical Sciences 26, no. 1 (2022): 67–77. http://dx.doi.org/10.15218/zjms.2022.008.

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Background and objective: Atorvastatin calcium is an antihyperlipidemic agent that is characterized by low aqueous solubility and high membrane permeability. This study was designed to enhance the solubility and the dissolution rate of atorvastatin calcium in the water and physiological pH (pH 6.8) by using L-Leucine as solubilizing agent utilizing different solid dispersion methods. Methods: Solid dispersion masses were prepared by kneading method and solvent evaporation methods at different weight ratios (1:1, 1:2: and 1:4) of the drug to the carrier. Saturated solubility studies were carrie

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Qader, Hemn, Hewa Hamadameen, and Anjam Abdullah. "Improvement of solubility and dissolution rate of Biopharmaceutical Class II drug atorvastatin calcium by using an essential amino acid L-leucine." Zanco Journal of Medical Sciences 26, no. 1 (2022): 67–77. http://dx.doi.org/10.15218/zjms.2022.008.

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Background and objective: Atorvastatin calcium is an antihyperlipidemic agent that is characterized by low aqueous solubility and high membrane permeability. This study was designed to enhance the solubility and the dissolution rate of atorvastatin calcium in the water and physiological pH (pH 6.8) by using L-Leucine as solubilizing agent utilizing different solid dispersion methods. Methods: Solid dispersion masses were prepared by kneading method and solvent evaporation methods at different weight ratios (1:1, 1:2: and 1:4) of the drug to the carrier. Saturated solubility studies were carrie

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Karike, Girija *. Koppula Maheshwari B. Anusha Ramya Sri Sura. "FORMULATION AND EVALUATION OF SOLUBILITY ENHANCEMENT OF LOVASTATIN FAST DISSOLVING TABLETS BY USING ION EXCHANGE RESINS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2946–56. https://doi.org/10.5281/zenodo.1231008.

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The present study investigated that the fast dissolving tablets of Lovastatin by ion exchange resin. DRC prepared by physical mixing and solvent evaporation method. Sodium starch glycolate and Crospovidone were used as super disintegrants. Formulations prepared by physical mixing and solvent evaporation blends were taken for pre and post compression studies. Those all found to be within limits. From dissolution data among all formulations I11 formulation containing DRC with solvent evaporation method along with CP as super disintegrant has shown maximum drug release within 10 min. Hence it con

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Winantari, Agnes Nuniek, Roisah Nawatila, and Cecilia Jocelyn. "PREPARATION OF ACYCLOVIR-ISONICOTINAMIDE COCRYSTAL BY SOLVENT EVAPORATION METHOD WITH METHANOL AND ISOPROPANOL." Jurnal Sains Materi Indonesia 21, no. 3 (2020): 109. http://dx.doi.org/10.17146/jsmi.2020.21.3.5897.

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PREPARATION OF ACYCLOVIR-ISONICOTINAMIDE COCRYSTAL BY SOLVENT EVAPORATION METHOD WITH METHANOL AND ISOPROPANOL. Acyclovir is a nucleoside synthetic analog antiviral group used in the treatment of Herpes simplex virus (HSV-1 & HSV-2) and Varicella zoster virus (VZV). Acyclovir has low water solubility, so it needs to be modified in the form of cocrystal with isonicotinamide. This study aims to obtain the physical characteristics produced by acyclovir-isonicotinamide cocrystal (1:1) made through the solvent evaporation method with methanol and isopropanol. The crystalline formed is character

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Yushkin, Alexey A., Alexey V. Balynin, Mikhail E. Efimov, Galina Karpacheva, and Alexey V. Volkov. "Preparation of Fine Porous Ultrafiltration Membranes from Polyacrylonitrile." Key Engineering Materials 869 (October 2020): 437–42. http://dx.doi.org/10.4028/www.scientific.net/kem.869.437.

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PAN membranes were prepared from mixture of good and weak solvents by two different methods. Immersion precipitation method with and without volatile component evaporation used for membrane preparation. From analysis of Hansen solubility parameters DMSO chosen as good solvent and acetone chosen as weak solvent. The effect of volatile weak solvent investigated on pore size and filtration performance. By evaporation of acetone, it was possible to increase polymer concentration on casting solution and obtain smaller pore size in comparison to membrane prepared from DMSO. Membranes prepared from D

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Enkhtuul, S., and M. Munkhshur. "Formation of polymer nanoparticles by self organized precipitation method." Mongolian Journal of Chemistry 14 (October 1, 2014): 33–35. http://dx.doi.org/10.5564/mjc.v14i0.195.

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Polymer nanoparticles have been investigated with great interest due to their potential applications in the fields of electronics, photonics and biotechnology. Here, we demonstrated the formation of polymer nanoparticles from a tetrafydrofuran/water mixture solution. Polymer nanoparticles remained as dispersed particles in the poor solvent (water) when good solvent (THF) is evaporated. Homogeneous nucleation and successive growth of polymer particles takes place during the dynamic nonequilibrium process of solvent evaporation. The size of the particles ranging from hundreds of nanometers to mi

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Muhaimin, Muhaimin, and Anis Yohana Chaerunisaa. "Solvent Type Effect on Preparation of Ethyl Cellulose Microparticles." Indonesian Journal of Pharmaceutical Science and Technology 10, no. 3 (2023): 127. http://dx.doi.org/10.24198/ijpst.v10i3.38460.

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The purpose of this study was to investigate effect of solvent type on solidification rate of ethyl cellulose(EC) microparticles and particle size/distribution of emulsion droplets/hardened microparticlesduring solvent evaporation process using focused beam reflectance measurement (FBRM). ECmicroparticles were prepared by an O/W-solvent evaporation method using various solvents, includingdichloromethane, dichloromethane:methanol (1:1), ethyl acetate and chloroform. The particle size/distribution of emulsion droplets/hardened microparticles was monitored by FBRM. The morphologyof EC micropartic

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Azad, A. K., K. Jahan, TS Sathi, R. Sultana4, SA Abbas, and ABMH UddinUddin. "IMPROVEMENT OF DISSOLUTION PROPERTIES OF ALBENDAZOLE FROM DIFFERENT METHODS OF SOLID DISPERSION." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 475–80. http://dx.doi.org/10.22270/jddt.v8i5.1942.

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Poor aqueous solubility of drugs results in poor absorption and bioavailability. The objective of Solid dispersion technology is to increase the dissolution properties of highly lipophilic drugs, by using different hydrophilic carriers thereby improving their bioavailability. This technology is useful for enhancing the dissolution, absorption and therapeutic efficacy of drugs in dosage forms. Albendazole is a broad-spectrum antihelminthic agent used for the treatment of a variety of parasitic worm infestations. It is practically insoluble in water but slightly soluble in solvents like chlorofo

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Sulistyowaty, Melanny Ika, Dwi Setyawan, Putu Pradnya Mimba Prameswari, et al. "A Comparison Study between Green Synthesis of Microwave Irradiation and Solvent Evaporation Methods in The Formation of p-Methoxycinnamic Acid-Succinic Acid Cocrystals." Science and Technology Indonesia 9, no. 3 (2024): 629–36. http://dx.doi.org/10.26554/sti.2024.9.3.629-636.

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Cocrystal of p-Methoxycinnamate acid-succinic acid has been produced by microwave irradiation and solvent evaporation methods. Cocrystals are formed using succinic acid as the coformer at a molar ratio of 1:1. The formation of cocrystal can be done by solvent evaporation method and microwave radiation method. Physicochemical properties have been studied by FT-IR, DSC, PXRD, and SEM analysis. The solubility test was carried out with pH 6.8 phosphate buffer at a temperature of 25±0.5°C for 5 hours and the dissolution test was carried out with 900 mL pH 6.8 phosphate buffer at a temperature of 37

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10

Shah, Pervaiz Akhtar, Haroon Khalid Syed, Abdul Rehman Sohail, et al. "Comparison of solvent evaporation and ultrasonicassisted production methods in the development of nimesulide nanosponges and their characterization." Tropical Journal of Pharmaceutical Research 21, no. 6 (2022): 1139–45. http://dx.doi.org/10.4314/tjpr.v21i6.1.

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Purpose: To compare solvent evaporation and ultrasonic assisted synthesis in preparation of nimesulide nanosponges using polyvinyl-alcohol and Eudragit L100 as a polymer/copolymer and dichloromethane as a cross linker.Methods: Twelve formulations of nimesulide were prepared, six with each method by varying the ratios of both polymer and co-polymer. The resulting nanosponges were evaluated characterized by preformulation studies, production yield (%), differential scanning calorimeter, x-ray diffraction, Fourier transformation infrared spectroscopy, scanning electron microscopy, entrapment effi

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Subedi, Gunjan, Ashwinee Kumar Shrestha, and Shailendra Shakya. "Study of Effect of Different Factors in Formulation of Micro and Nanospheres with Solvent Evaporation Technique." Open Pharmaceutical Sciences Journal 3, no. 1 (2016): 182–95. http://dx.doi.org/10.2174/1874844901603010182.

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Background: There are various methods of formulation of micro and nanospheres such as solvent evaporation, solvent removal, polymerization, hot-melt encapsulation, coacervation, phase/wet inversion, spray drying, spray congealing etc. Amongst these all, solvent evaporation is one of the most widely used, researched, easy, accessible methods and for which many patents have been applied. It is thus imperative to understand the basics of effect of formulation variables and design of solvent evaporation method which will be covered in this review article. Objective: To discuss the various formulat

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Adhikari, L., M. Semalty, P. S. Naruka, V. K. Aswal та A. Semalty. "BINARY COMPLEXES OF GLIMEPIRIDE WITH Β-CYCLODEXTRIN FOR IMPROVED SOLUBILITY AND DRUG DELIVERY". INDIAN DRUGS 56, № 03 (2019): 54–60. http://dx.doi.org/10.53879/id.56.03.11714.

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Cyclodextrin complexation is a one of the most investigated techniques of solubility and dissolution enhancement of drugs. In the present study, a poorly water soluble drug glimepiride, was complexed with β-cyclodextrin (βCD) with the aim of improving water solubility and drug dissolution. The complexes were prepared using two different methods (solvent evaporation and kneading) and then characterized by Fourier-transform infrared spectroscopy (FT-IR), powder x-ray diffractometry (X-RD), thermal analysis (DSC),scanning electron microscopy and in-vitro dissolution study. The phase solubility st

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13

Zhang, Zhengyu, Qiuyu Liu, Ying Yan, and Ping Zhou. "The measurement method of solvent evaporation rate of photoresist liquid film based on monochromatic light interference." Journal of Physics: Conference Series 2819, no. 1 (2024): 012016. http://dx.doi.org/10.1088/1742-6596/2819/1/012016.

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Abstract The solvent evaporation rate of the photoresist is a crucial parameter in the spin coating process, influencing process conditions and product quality. When the thickness of the film changes rapidly, the difference between the evaporation obtained through static testing and the actual evaporation during the process becomes significant. Therefore, there is a pressing need for an in-situ method to measure evaporation in situ. This study proposed a method for measuring the solvent evaporation rate of photoresist liquid film based on monochromatic light interference. The hardware of the m

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Yoo, Okhee, Sam Salman, Britta S. von Ungern-Sternberg, and Lee Yong Lim. "Taste-Masked Flucloxacillin Powder Part 1: Optimisation of Fabrication Process Using a Mixture Design Approach." Pharmaceuticals 16, no. 8 (2023): 1171. http://dx.doi.org/10.3390/ph16081171.

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It is extremely challenging to formulate age-appropriate flucloxacillin medicines for young children, because flucloxacillin sodium (FS) has a lingering, highly bitter taste, dissolves quickly in saliva, and requires multiple daily dosing at relatively large doses for treating skin infections. In this paper, we describe a promising taste-masked flucloxacillin ternary microparticle (FTM) formulation comprising FS, Eudragit EPO (EE), and palmitic acid (PA). To preserve the stability of the thermolabile and readily hydrolysed flucloxacillin, the fabrication process employed a non-aqueous solvent

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15

V. Le, Anh, Sophie E. Parks, Minh H. Nguyen, and Paul D. Roach. "Improving the Vanillin-Sulphuric Acid Method for Quantifying Total Saponins." Technologies 6, no. 3 (2018): 84. http://dx.doi.org/10.3390/technologies6030084.

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The colorimetric assay used for saponin quantification in plant extracts is subject to interference by common solvents used to extract the saponins from plant materials. Therefore, the degree of interference of ten common solvents was investigated. It was found that the presence of acetone, methanol and n-butanol in the reaction solution caused an intense darkening of the reaction solution in the absence of saponins, which likely could lead to erroneous saponin content values. Using aescin to construct standard curves with different solvents—such as water, ethanol, and methanol— also showed si

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Park, Chan-Su, Ji-Won Lee, and Nam-Ju Jo. "Microencapsulation of Thermoplastic Polyurethane by Solvent Evaporation Method." Polymer Korea 43, no. 1 (2019): 92–98. http://dx.doi.org/10.7317/pk.2019.43.1.92.

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17

Jiao, Zhen, Na Liu, and Zhiming Chen. "Selection suitable solvents to prepare paclitaxel-loaded micelles by solvent evaporation method." Pharmaceutical Development and Technology 17, no. 2 (2010): 164–69. http://dx.doi.org/10.3109/10837450.2010.529146.

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18

Imran, Khan, Gaurav Bhaduka Dr., and Dilip Agrawal Dr. "Formulation, Development and Evaluation of Floating Microspheres of Nizatidine for Gastroretentive Drug Delivery." Pharmaceutical and Chemical Journal 12, no. 3 (2025): 1–13. https://doi.org/10.5281/zenodo.15606949.

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Floating microspheres loaded with Nizatidine were prepared using solvent- evaporation method using HPMC, Eudragit RL 100, Eudragit RLPO in different ratio polymers. Drug and polymer in proportion of drug and polymers were dissolved in 1:2 mixture of solvent system of ethanol and dichloromethane. Floating microspheres of Nizatidine were prepared by a solvent diffusion- evaporation method. The nature of polymer influenced the physical characteristics as well as floating behaviour of the microspheres. In vitro buoyancy and in vivo studies confirmed the excellent floating properties of HPMC, Eudra

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19

Wang, Jian, Jichuan Wu, Shouqi Yuan, and Wei-Cheng Yan. "CFD simulation of ultrasonic atomization pyrolysis reactor: the influence of droplet behaviors and solvent evaporation." International Journal of Chemical Reactor Engineering 19, no. 2 (2021): 167–78. http://dx.doi.org/10.1515/ijcre-2020-0229.

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Abstract Previous work showed that particle behaviors in ultrasonic atomization pyrolysis (UAP) reactor have a great influence on the transport and collection of particles. In this study, the effects of droplet behaviors (i.e. droplet collision and breakage) and solvent evaporation on the droplet size, flow field and collection efficiency during the preparation of ZnO particles by UAP were investigated. The collision, breakage and solvent evaporation conditions which affect the droplet size distribution and flow pattern were considered in CFD simulation based on Eulerian-Lagrangian method. The

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20

Rahman, Tanvir, Md Abdurrahim, Koma Afrin Rintu, et al. "Improvement of in vitro dissolution profile of poorly aqueous soluble anti-parasitic agent ivermectin using novel hydrophilic polymeric carriers." Bangladesh Journal of Scientific and Industrial Research 58, no. 4 (2023): 209–20. http://dx.doi.org/10.3329/bjsir.v58i4.69047.

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Ivermectin (IVM), a BCS Class II drug with weak water solubility, has minimal oral absorption and dissolution. This study aims to enhance the dissolution profile of IVM by performing solid dispersion methods using four hydrophilic polymers: Kollicoat IR, Kollidon 90F, poloxamer 407, and hydroxypropyl methylcellulose (HPMC). The solid dispersion formulations (SDF) were made through physical mixing, solvent evaporation, and melt solvent/fusion. Using three ratios of IVM and hydrophilic carriers (1:1, 1:2, and 1:3), the cumulative release rate of IVM from formulations formed by physical mixing, s

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Soyata, Amelia, Kenti Kenti, Meylani Sutoro, and Novaliana Sagita. "Impact of Preparation Method in Co-Amorphous System." Sciences of Pharmacy 1, no. 1 (2022): 41–49. http://dx.doi.org/10.58920/sciphar01010041.

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The co-amorphous solid dispersion system is one of the methods to improve the physicochemical characteristics and stability of a drug. With the appropriate material ratio and preparation method, a co-amorphous solid dispersion system can increase the bioavailability of the drug due to an increase in solubility. In addition, the co-amorphous system will maintain its amorphous shape longer than a single compound. However, using unsuitable materials and methods for co-amorphous fabrication will precipitate them and diminish their bioavailability. As a result, exploring the fundamentals of co-amor

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Lubasova, Daniela, and Lenka Martinova. "Controlled Morphology of Porous Polyvinyl Butyral Nanofibers." Journal of Nanomaterials 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/292516.

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A simple and effective method for the fabrication of porous nanofibers based on the solvent evaporation methods in one-step electrospinning process from the commercial polyvinyl butyral (PVB) is presented. The obtained nanofibers are prevalently amorphous with diameters ranging from 150 to 4350 nm and specific surface area of approximately 2–20 m2/g. Pore size with irregular shape of the porous PVB fibers ranged approximately from 50 to 200 nm. The effects of polymer solution concentration, composition of the solvents mixture, and applied voltage on fiber diameter and morphology were investiga

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Huling, Jennifer, Beate Lyko, Sabine Illner, Nicklas Fiedler, Niels Grabow, and Michael Teske. "Development of UV-Reactive Electrospinning Method Based on Poly(ethylene glycol) diacrylate Crosslinking." Current Directions in Biomedical Engineering 6, no. 3 (2020): 189–92. http://dx.doi.org/10.1515/cdbme-2020-3048.

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AbstractElectrospinning is a popular method for creating nonwoven fiber materials for a wide variety of applications. In the field of biomaterials, electrospun materials are favoured because of a high surface-to-volume ratio which can be useful for drug loading and release, and because nanoscale fibers mimic native tissue structures, improving cell interactions. However limitations exist with regards to traditional solvent evaporation-based electrospinning techniques. A new area of research into reactive electrospinning is investigating methods of electrospinning that rely on in situ crosslink

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Nagda, Chirag*l Chotai Narendra2 Patel Sandipl Patel Upendraa Ahir Keyurı Nagda Dhruti. "Design and characterization of bioadhesive microspheres prepared by double emulsion solvent evaporation method." Acta Pharmaceutica Sciencia 51, no. 1 (2009): 261–70. https://doi.org/10.5281/zenodo.8154697.

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Atneriya, Umesh K., Dharmendra Solanki, Komal Tikariya, and Arpit Gawshinde. "Development of fast release tablet of talinolol using fourth generation carrier of solid dispersion technique." Journal of Pharmaceutical and Biological Sciences 11, no. 1 (2023): 35–42. http://dx.doi.org/10.18231/j.jpbs.2023.007.

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Talinolol is a beta1-selective adreno receptor antagonist well known for its Cardio protective and antihypertensive activity. Talinolol is a beta blocker. In biopharmaceutical classification system the drugs which come under class II are characterized by more membrane permeability, less dissolution rate. Talinolol is a poor aqueous solubility drug leads to poor bioavailability. So, the aimed of this study was to develop immediate release tablet of talinolol by solid dispersions technique using poloxamer 407 as a carrier. Poloxamer 407 is a hydrophilic synthetic block copolymer widely used as a

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Hamzah, Raja Nurul Batrisyia, Long Chiau Ming, A. B. M. Helal Uddin, Zaidul Islam Sarker, Kai Bin Liew, and Yik Ling Chew. "Comparison of Microemulsion and Solvent Evaporation Technique for Solubility Enhancement of Amlodipine Besylate." JULY ISSUE 18, no. 4 (2022): 135–40. http://dx.doi.org/10.47836//mjmhs18.4.19.

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Introduction: Amlodipine besylate is a calcium channel blocker indicated for hypertension and angina. It is described as slightly soluble in water and due to its limited solubility, it may result in poor bioavailability. The aim of this study is to enhance the solubility of amlodipine besylate using solvent evaporation method and microemulsion technique and to compare the two methods. Method: Solid dispersions (SD) of amlodipine besylate were developed by employing solvent evaporation method. PEG6000 was the polymer of choice and different drug:polymer ratios were used. Evaluation of the prepa

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Asghari-Varzaneh, Elham, Mohammad Shahedi, and Hajar Shekarchizadeh. "Iron microencapsulation in gum tragacanth using solvent evaporation method." International Journal of Biological Macromolecules 103 (October 2017): 640–47. http://dx.doi.org/10.1016/j.ijbiomac.2017.05.047.

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Aglawe, Sachin B.* Gayke A. U. Metkar P. S. Sancheti V.P. Palghadmal P.S. Mohan R.S. "FORMULATION AND EVALUATION OF LOSARTAN POTASSIUM MICROSPHERES BY SOLVENT EVAPORATION METHOD." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 735–43. https://doi.org/10.5281/zenodo.1036343.

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Losartan Potassium loaded microspheres were prepared by solvent evaporation method with combination of hydroxy propyl methyl cellulose and Carbopol polymers in various proportions. A total of nine formulations were prepared. The particle size of all the formulations were ranged between 112±0.02 and 183±0.01μm. The entrapment efficiency was ranged between 68.38±0.01 and 93.16±0.01 All formulations were evaluated for further studies like micromeretic properties, swelling index and in-vitro release profile. It was confirmed with the results of micromeretic property that all the selected formulati

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Ko, Jong Tae, Hyung Joon Jung, Jong Hyon Mo, et al. "The Double-Layered Microsphere: Encapsulation of Water-Soluble Protein with PLGA." Key Engineering Materials 342-343 (July 2007): 513–16. http://dx.doi.org/10.4028/www.scientific.net/kem.342-343.513.

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The double-layered microspheres play an important role in controlling drug delivery for pharmaceutical application, because of the low initial burst compared with single-layered spheres and targetable delivery to specific organ. But it has drawback in loading drug and controlling size. In this study, we developed double-layered spheres using relatively simple oil-in-water (O/W) solvent evaporation method using bovine serum albumin (BSA) as water-soluble protein and poly(D,L-lactide-co-glycolide) (PLGA). BSA/PLGA double-layered microspheres were fabricated using O/W solvent evaporation method a

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Tuntarawongsa, Sarun, and Thawatchai Phaechamud. "Application of Eutectic Solvent to Preparation of Ibuprofen Suspension by Emulsion Evaporation Method." Advanced Materials Research 1060 (December 2014): 188–91. http://dx.doi.org/10.4028/www.scientific.net/amr.1060.188.

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Menthol was used as sublimate eutectic compound to prepare the volatile eutectic solvent by mixing with camphor, borneol orN-Ethyl-5-methyl-2-(1-methylethyl) cyclohexanecarboxamide (WS-3). The system of menthol:camphor, menthol:borneol and menthol:WS-3 in various ratio (1:9 to 9:1) was characterized. The 5:5 menthol:camphor system showed the highest evaporation rate. Ibuprofen dissolved in eutectic solvent was used as internal phase of emulsion whereas tween80 was used as emulsifier. Eutectic solvent was evaporated to induce the transformation of emulsion droplet to small particle. Eutectic co

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Wicaksono, Yudi, Dwi Setyawan, and Siswandono Siswandono. "Formation of Ketoprofen-Malonic Acid Cocrystal by Solvent Evaporation Method." Indonesian Journal of Chemistry 17, no. 2 (2017): 161. http://dx.doi.org/10.22146/ijc.24884.

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The purpose of this work was to explore the formation of ketoprofen-malonic acid cocrystal by solvent evaporation method. Early detection of cocrystal formation was conducted by hot stage microscopy and solid-liquid phase diagram. Cocrystal were prepared by solvent evaporation method by using isopropyl alcohol as solvent. Characterization of cocrystal was done by Powder X-Ray Diffractometry (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR) Spectroscopy and Scanning Electron Microscopy (SEM). The results of hot stage microscopic and solid-liquid phase diagram in

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Pamula, Reddy Bhavanam*. "FORMULATION AND DEVELOPMENT OF ZOLPIDEM TARTRATE FAST DISSOLVING FILMS BY USING SODIUM CMC." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 2735–40. https://doi.org/10.5281/zenodo.886323.

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Drug is used for the treatment of insomnia and some brain disorders. The purpose of the present work is to formulate and enhance the drug release of zolpidem tartrate by the incorporation of suitable polymer in the oral dissolving films (OTF) for use in specific populations viz. geriatrics and patients experiencing difficulty in swallowing. The oral dissolving films loaded with zolpidem tartrate were prepared by solvent evaporation method using sodium CMC by adding suitable plasticizer glycerin. The prepared oral dissolving films were evaluated for drug content, weight variation, thickness, pH

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Cheng, Yingying, Yitong Ji, Dongyang Zhang, et al. "Nitrogen-Blowing Assisted Strategy for Fabricating Large-Area Organic Solar Modules with an Efficiency of 15.6%." Polymers 16, no. 11 (2024): 1590. http://dx.doi.org/10.3390/polym16111590.

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Organic solar cells (OSCs) are one of the most promising photovoltaic technologies due to their affordability and adaptability. However, upscaling is a critical issue that hinders the commercialization of OSCs. A significant challenge is the lack of cost-effective and facile techniques to modulate the morphology of the active layers. The slow solvent evaporation leads to an unfavorable phase separation, thus resulting in a low power conversion efficiency (PCE) of organic solar modules. Here, a nitrogen-blowing assisted method is developed to fabricate a large-area organic solar module (active

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Hitesh Jain, Vimla Chaudhary, Vaishnavi Kamath, Dipal Prajapati, and D. B. Meshram. "Formulation and evaluation of solid dispersion method based fast dissolving tablet of cilnidipine." GSC Biological and Pharmaceutical Sciences 22, no. 1 (2023): 345–50. http://dx.doi.org/10.30574/gscbps.2023.22.1.0039.

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Background: The objective of this work was to enhance the solubility and dissolution rate for rapid onset of anti-hypertensive action of cilnidipine. Method: To enhance the solubility of cilnidipine solvent evaporation method was used. In solvent evaporation method polymer like HPMC, PVP K30, PEG 4000 and PEG 6000(for binary solid dispersion) and poloxamer 188(for ternary solid dispersion) were used in the different drug polymer ratio. Conclusion: Among them cilnidipine: HPMC: poloxamer 188 shows better solubility and also different physical characterization test like DSC and XRD. After select

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Suripeddi, Muralidhar, Venkata Narayana Taneeru, Sumalatha Gindi, and Ramya.K. "Improvement of Dissolution Properties of Etoricoxib through Solid Dispersion Technique." RA JOURNAL OF APPLIED RESEARCH 08, no. 06 (2022): 446–49. https://doi.org/10.5281/zenodo.6618769.

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ABSTRACT: Etoricoxib, a non-steroidal anti-inflammatory drug, is used to Osteoarthritis, Rheumatoid arthritis and Acute Gouty arthritis. Etoricoxib is practically insoluble in water; hence present study was carried out to enhance dissolution properties of Etoricoxib through the preparation of Solid Dispersions using Mannitol, PEG 6000 and PVP K30 as carriers at various proportions by using Solvent Evaporation Method. The drug release profile was studied in 0.1N HCl containing 0.75 % SLS. U.V. Spectrophotometric method was selected for assay as well as in-vitro dissolution studies at 234nm. The

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N., Umarani. "Design, Prepare, and Characterization of Erythrina Variegata Loaded Solid Lipid Nanoparticles." International Journal of Pharmacy and Biological Sciences (IJPBS) 13, no. 3 (2023): 70–75. https://doi.org/10.5281/zenodo.10373863.

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AbstractThe goal of this study was to assess the efficacy of a method based on the creation of solid lipid nanoparticles as an innovative formulation of Erythrina Variegata with enhanced therapeutic efficacy. The Erythrina Variegata solid lipid nanoparticles were created using the Sonicator to apply ultrasonic energy during the emulsification solvent evaporation process. The numerous formulations with varied drug-lipid and surfactant ratios were analysed and improved. Erythrina Variegata solid lipid nanoparticles containing soy lecithin were created using the solvent evaporation method, then t

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Hill, Elizabeth, David Ensor, Phil Lawless, and Robert Donovan. "Application of a Commercial Nonvolatile Residue Monitor to Measure Purity of Solvents and Surface Cleanliness." Journal of the IEST 36, no. 4 (1993): 28–30. http://dx.doi.org/10.17764/jiet.2.36.4.q53201467460m871.

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A nonvolatile residue monitor was used to determine the cleanliness levels of deionized water, pure solvents, and solutios used to measure surface cleanliness by extraction. The measurement is rapid, repeatable, and simple to perform. With the use of calibration curves, it provides a quantitative measure of nonvolatile residue (NVR). This method can be used to replace other procedures that require evaporation of large volumes of solvent, saving time and reducing solvent emissions. The detection limit is in the nanogram range for many common nonvolatile residues.

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Patel, Ayushi, Rupesh Kumar Jain, Vivek Jain, and Pushpendra Kumar Khangar. "Formulation and Evaluation of Sustained Release Solid Dispersed Nifedipine Microcapsules." Asian Journal of Dental and Health Sciences 2, no. 3 (2022): 12–18. http://dx.doi.org/10.22270/ajdhs.v2i3.21.

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Conventional drug delivery system for treating the angina and hypertension are not much effective as the drug do not reach the site of action in appropriate amounts. Thus potent and guarded therapy of this angina and hypertension disorder using specific drug delivery system is a challenging task to the pharmaceutical professionals. The study was aimed at increase the solubility of poorly soluble drug nifedipine and formulating it in sustained release dosage form. Solid dispersion of drug was prepared using Poly vinyl pyrrolidone (PVP) as inert hydrophilic carriers by solvent evaporation techni

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Bhardwaj, Sahil, Ajeet Pal Singh, and Amar Pal Singh. "Formulation and Evaluation of Betulin Loaded Transdermal Patches." Journal of Drug Delivery and Therapeutics 14, no. 5 (2024): 113–21. http://dx.doi.org/10.22270/jddt.v14i5.6578.

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Objectives: To develop and evaluate Transdermal patches of Betulin along with various polymers for controlled release action. Method: Suitable method such as Solvent Casting Technique of Film Casting Technique are used for preparation of Transdermal patch. Result: The prepared Transdermal patches were transparent, smooth, uniform and flexible. The method adopted for preparation of system was found satisfactory. Conclusion: Various formulations were developed by using hydrophilic and hydrophobic polymers like HPMC E5 and EC respectively in single and combinations by solvent evaporation techniqu

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Kumar, Balagani Pavan, Irisappan Sarath Chandiran, and Korlakunta Narasimha Jayaveera. "Formulation development and evaluation of Glibenclamide loaded Eudragit RLPO microparticles." International Current Pharmaceutical Journal 2, no. 12 (2013): 196–201. http://dx.doi.org/10.3329/icpj.v2i12.17016.

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The objective of the present investigation was to formulate and evaluate microencapsulated Glibenclamide produced by the emulsion solvent evaporation method. Microparticles were prepared using Eudragit RLPO by emulsion solvent evaporation method and characterized for their micromeritic properties, encapsulation efficiency, particle size, drug loading, FTIR, DSC, SEM analysis. In vitro release studies were performed in phosphate buffer (pH 7.4). Stability studies were conducted as per ICH guidelines. The resulting microparticles obtained by solvent evaporation method were free flowing in natu

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ARAGÓN, D. M., J. E. ROSAS, and F. MARTÍNEZ. "EFFECT OF THE IBUPROFEN SOLUBILITY IN ACETONE AND DICHLOROMETHANE ON THE DRUG RELEASE PROFILES FROM PLGA MICROSPHERES." Latin American Applied Research - An international journal 44, no. 1 (2014): 87–92. http://dx.doi.org/10.52292/j.laar.2014.423.

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Acetone and dichloromethane were used as organic solvent to prepare ibuprofen-loaded PLGA microspheres by the emulsion-solvent evaporation method. Some microspheres properties, such as microencapsulation efficiency and particle size, were affected by the organic solvent used. Depending on the organic solvent used microparticles obtained exhibited different controlled release profiles. In all cases it was extended up to 15 days. The obtained formulations did not exhibit zero- or first-order release kinetics and non-agreement with the Higuchi or Korsmeyer-Peppas models was found. On the other ha

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Vaishali, shinde Krushna Shinde. "Formulation and Development of Naproxen loaded Polymeric Nanoparticles using the Solvent Evaporation Method." International Journal of Pharma Research and Technology 1, no. 4 (2022): 1–7. https://doi.org/10.5281/zenodo.7479061.

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Oil in water (O/W) emulsion solvent evaporation was used to develop polymeric drug nanoparticles for this study. Water served as a non-solvent and the polymer's solvent was acetone. The emulsion solvent evaporation method will be used in this study to prepare nanoparticles and to analyze the effects of different processing parameters on the properties of the nanoparticles. We use two different types of acrylic polymers in this study: Eudragit E100 and Eudragit RS100. It was observed that various factors, including the polymer content in the organic solvent, the concentration of the surfact

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Wisudyaningsih, Budipratiwi, Dwi Setyawan, and Siswandono. "Co-crystallization of quercetin and isonicotinamide using solvent evaporation method." Tropical Journal of Pharmaceutical Research 18, no. 4 (2021): 697–702. http://dx.doi.org/10.4314/tjpr.v18i4.3.

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Purpose: To obtain quercetin-isonicotinamide co-crystal (CQINA) with improved physicochemical and in-vitro dissolution characteristics. Methods: Co-crystallization of quercetin (Q) and isonicotinamide (INA) in molar ratio of 1:1 was performed using solvent evaporation method with the addition of 50 mL of ethanol (99.9%, v/v). The resultant solution was thoroughly mixed and stirred at room temperature for 48 h to slowly evaporate the solvent until CQINA was obtained. The co-crystal phase was characterized using differential scanning calorimetry (DSC), powder x-ray diffractometry (PXRD), s

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Winantari, Agnes Nuniek, Dwi Setyawan, Siswandono Siswodihardjo, and Sundono Nurono Soewandhi. "COCRYSTALLIZATION ACYCLOVIR-SUCCINIC ACID USING SOLVENT EVAPORATION METHODS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 6 (2017): 91. http://dx.doi.org/10.22159/ajpcr.2017.v10i6.16369.

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Objective : The aim of this research is to prepare and characterize cocrystals of acyclovir through cocrystallization of acyclovir – succinic acid (AS) to improve the physical properties of the drug. Methods : AS cocrystals was prepared using solvent evaporation method. The cocrystals were characterized by Polarization Microscope, Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Powder X-Ray Diffraction (PXRD), and Fourier Transform Infrared Spectroscopy (FTIR).Results : Physical characterization using polarization microscope and SEM showed the AS cocrystals have un

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Srinivas, Poojary Pooja, Nishank Prabhu, Vasantharaju SG, et al. "DESIGNING OF STABLE CO-CRYSTALS OF AZITHROMYCIN USING SUITABLE COFORMERS." RASAYAN Journal of Chemistry 15, no. 04 (2022): 2417–28. http://dx.doi.org/10.31788/rjc.2022.1546985.

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In this present study, a new co-crystal of azithromycin with nicotinamide and naringenin has been developed with improved solubility. Azithromycin is a class II drug with poor aqueous solubility; hence an attempt has been made to improve its solubility through co-crystallization technology. In this study, the coformers selected were nicotinamide and naringenin based on ease of hydrogen bond formation. The co-crystal of azithromycin with nicotinamide was prepared in three ratios (1:1, 1:2, and 2:1) by dry grinding and slow solvent evaporation method. The co-crystal of azithromycin with naringen

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YONEYAMA, Fumiharu, and Toshinori MAKUTA. "J0440205 Hollow Chloroprene Rubber Particles Fabricated by Solvent Evaporation Method." Proceedings of Mechanical Engineering Congress, Japan 2014 (2014): _J0440205——_J0440205—. http://dx.doi.org/10.1299/jsmemecj.2014._j0440205-.

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He, Y. X. "Solvent Evaporation Method and Crystal Structure of Thiophene-2,3-dicarboxylate." Asian Journal of Chemistry 27, no. 2 (2015): 769–70. http://dx.doi.org/10.14233/ajchem.2015.17424.

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Zhou, Zhimin, Jun Xu, Xiaoqing Liu, et al. "Non-spherical racemic polylactide microarchitectures formation via solvent evaporation method." Polymer 50, no. 15 (2009): 3841–50. http://dx.doi.org/10.1016/j.polymer.2009.05.047.

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Xiao, Chao-Da, Xiang-Chun Shen, and Ling Tao. "Modified emulsion solvent evaporation method for fabricating core–shell microspheres." International Journal of Pharmaceutics 452, no. 1-2 (2013): 227–32. http://dx.doi.org/10.1016/j.ijpharm.2013.05.020.

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Zhang, Qi, Yan Han, Wei-Cai Wang, Lei Zhang, and Jin Chang. "Preparation of fluorescent polystyrene microspheres by gradual solvent evaporation method." European Polymer Journal 45, no. 2 (2009): 550–56. http://dx.doi.org/10.1016/j.eurpolymj.2008.11.016.

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