Relevant bibliographies by topics / Somatic cell hybridization

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Somatic cell hybridization'

Author: Grafiati
Published: 4 June 2025
Last updated: 23 June 2025

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Journal articles on the topic "Somatic cell hybridization"

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Holmes, Matthew. "Somatic Hybridization." Historical Studies in the Natural Sciences 48, no. 1 (2018): 1–23. http://dx.doi.org/10.1525/hsns.2018.48.1.1.

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Somatic hybridization is the particle collider of the biological world: where plant cells stripped of their cell wall are fused to create interspecific crosses containing a huge range of genetic information. This paper charts the origins of somatic hybridization and its rise and fall as a plant breeding technique. During the 1960s and 1970s, the creation of somatic hybrids through cell fusion promised a new era of crop improvement. Yet the promises of somatic hybridization were instead fulfilled by advances in recombinant DNA technology. Rather than cast somatic hybridization as a failed research program, this paper argues that a number of factors significantly slowed, but did not halt, developments in somatic hybridization research from the 1960s; the technique should therefore be considered a dormant biotechnology. Reconstructing the history of somatic hybridization reveals a new history of modern biotechnology beyond genetic modification, dominated by plant physiologists.
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Hall, Robert D., Gerard J. A. Rouwendal, and Frans A. Krens. "Asymmetric somatic cell hybridization in plants." Molecular and General Genetics MGG 234, no. 2 (1992): 306–14. http://dx.doi.org/10.1007/bf00283851.

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Hall, Robert D., Gerard J. A. Rouwendal, and Frans A. Krens. "Asymmetric somatic cell hybridization in plants." Molecular and General Genetics MGG 234, no. 2 (1992): 315–24. http://dx.doi.org/10.1007/bf00283852.

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Liu, Shuping, Xiaojie Li, Jiani Zhu, et al. "Modern Technologies Provide New Opportunities for Somatic Hybridization in the Breeding of Woody Plants." Plants 13, no. 18 (2024): 2539. http://dx.doi.org/10.3390/plants13182539.

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Advances in cell fusion technology have propelled breeding into the realm of somatic hybridization, enabling the transfer of genetic material independent of sexual reproduction. This has facilitated genome recombination both within and between species. Despite its use in plant breeding for over fifty years, somatic hybridization has been limited by cumbersome procedures, such as protoplast isolation, hybridized-cell selection and cultivation, and regeneration, particularly in woody perennial species that are difficult to regenerate. This review summarizes the development of somatic hybridization, explores the challenges and solutions associated with cell fusion technology in woody perennials, and outlines the process of protoplast regeneration. Recent advancements in genome editing and plant cell regeneration present new opportunities for applying somatic hybridization in breeding. We offer a perspective on integrating these emerging technologies to enhance somatic hybridization in woody perennial plants.
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Saïdi-Mehtar, N., M. Imam-Ghali, S. Heuertz, and MC Hors-Cayla. "Sheep gene mapping by somatic cell hybridization." Genetics Selection Evolution 23, Suppl 1 (1991): S196. http://dx.doi.org/10.1186/1297-9686-23-s1-s196.

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SANO, Hiroshi, Yoshio SUZUKI, and Kiyoharu OONO. "Somatic Cell Hybridization of Hyacinth Bean and Soybean." Plant tissue culture letters 5, no. 1 (1988): 15–19. http://dx.doi.org/10.5511/plantbiotechnology1984.5.15.

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JAKOBSSON, ANN-HELENE, BJÖRN DAHLLOF, TOMMY MARTINSSON, and GÖRAN LEVAN. "Transfer of methotrexate resistance by somatic cell hybridization." Hereditas 99, no. 2 (2008): 293–302. http://dx.doi.org/10.1111/j.1601-5223.1983.tb00901.x.

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Margulies, David H. "Monoclonal Antibodies: Producing Magic Bullets by Somatic Cell Hybridization." Journal of Immunology 174, no. 5 (2005): 2451–52. http://dx.doi.org/10.4049/jimmunol.174.5.2451.

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Hamano, T., Y. Murata, T. Yamasaki, Y. Yasuda, T. Iwasaki, and K. Nagai. "Establishment of an antigen-specific B cell clone by somatic hybridization." Journal of Immunology 139, no. 8 (1987): 2556–61. http://dx.doi.org/10.4049/jimmunol.139.8.2556.

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Abstract Splenic B cells of A/J mice immunized with 2,4,6-trinitrophenyl (TNP)-lipopolysaccharide were fused with 2.52M, a mutant of a B cell line, in the presence of polyethylene glycol and dimethyl sulfoxide. TP67.21, a subclone of a resulting hybridoma, expresses IAk, IEk, IgM, B220, P50, and receptors for C3 fragment of complement, the Fc portion of IgG, and interleukin 2 receptor on the cell membrane; it also possesses receptor molecules for TNP on its surface, derived from TNP-reactive B cells of A/J mice primed with TNP-lipopolysaccharide used for somatic hybridization, by a rosette-forming assay with TNP-sheep erythrocytes. In contrast, parental 2.52M lacks IAk and IEk on the cell membrane and does not bind to TNP-sheep erythrocytes under the same conditions. Thus, it is likely that TP67.21 is an antigen-specific B cell clone directed against TNP. The antigen binding of cells was markedly inhibited by the specific free hapten or anti-IgM antibodies. Interestingly, TP67.21 was induced to generate a significant amount of anti-TNP antibody when treated with TNP conjugates including T cell-independent and -dependent antigens, such as TNP-lipopolysaccharide, TNP-bovine serum albumin, TNP-ovalbumin, and TNP-keyhole limpet hemocyanine in the absence of T cell help, as well as polyclonal activators; this was followed by a marked decrease in the expression of B cell surface markers on the cell membrane. This suggests that the cross-linkage of receptor molecules on TP67.21 by antigen may directly provide a differentiative signal for maturation to a lineage of B cells, and consequently results in the generation of antigen-specific antibodies without T cell involvement.
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Hillmen, P., M. Bessler, J. Bungey, and L. Luzzatto. "Paroxysmal nocturnal hemoglobinuria: Correction of abnormal phenotype by somatic cell hybridization." Somatic Cell and Molecular Genetics 19, no. 2 (1993): 123–29. http://dx.doi.org/10.1007/bf01233528.

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Dissertations / Theses on the topic "Somatic cell hybridization"

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Whitaker, Noel James. "Somatic cell hybridisation analysis of SV40-immortalised human cells." Thesis, The University of Sydney, 1991. https://hdl.handle.net/2123/26432.

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Immortalisation is an important aspect of cancer cell biology. Whereas normal diploid mammalian cells have a finite lifespan in culture [Hayflick and Moorhead, 1961], tumours often contain cells that exhibit an apparently unlimited proliferative potential. In many experimental systems immortalisation appears to be an obligatory prerequisite for the induction of tumours [e.g. Newbold and Overell, 1983; O'Brien et al., 1986; Reddel et al., 1988b]. Human cells rarely, if ever, spontaneously immortalise in vitro but transfer of genes from DNA tumour viruses (e.g. simian virus 40 (SV40) early region genes) into normal human cells sometimes induces immortalisation [reviewed in Chang, 1986]. SV40 early region genes usually extend the in vitro lifespan of normal human cells, but immortalisation occurs only in rare variant cells that grow out after a period of crisis. These genes are therefore not sufficient for immortalisation. and presumably cellular genetic events are required for escape from crisis that results in immortalisation. The nature of these putative genetic changes is currently unknown. Somatic cell hybridisation studies indicate that the immortal phenotype is recessive, since hybrids between normal and immortal cells undergo senescence [Bunn and Tarrant, 1980; Muggleton-Ha rris and DeSimone, 1980; Pereira—Smith and Smith, 1981]. This technique has also been used to assign immortalised human cells to four complementation groups for immortality (referred to as groups A-D) [Pereira-Smit h and Smith, 1988]. By definition, when cell lines from different complementation groups are fused, some or all of the hybrids undergo senescence, i.e. complementation occurs to yield the senescent phenotype. With the exception of one SV40-immortalised cell line derived from an individual with a DNA repair deficiency, all SV40-immortalised cell lines previously analysed have been assigned to group A, which may imply that SV40 always induces immortalisation via the same cellular genetic event(s) [Pereira-Smith and Smith, 1988]. In order to use SV40-immortalised cells to study the processes of immortalisation, it is necessary to determine whether SV40-immortalised cell lines may be found in other complementa tion groups. This project studies a human bronchial epithelial cell line (BET-1A) and a human mesothelial cell line (MeT—5A) that were established following transfection of normal human bronchial epithelial and normal human mesothelial cells respecively, with a plasmid containing the SV40 early region genes [Reddel et al., 1988a; Ke et al., 1989]. Fusion with representatives of each of the four immortalisat ion complementation groups showed that both BET-1A and MeT-5A are not in complementa tion group A. BET-1A assigned to group D, but MeT-5A appeared to be in more than one complementa tion group. All of the hybrids continued to express the SV40 T antigen genes regardless of whether they eventually senesced or remained immortal, confirming that expression of these genes is not sufficient for immortalisat ion. Further, some hybrid clones which remained immortal were suppressed for tumourigenicity, demonstrating that induction of senescence is not necessary for tumour suppression.
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Höglund, Mattias. "The construction and use of interspecific somatic cell hybrids in reverse genetics an approach to the analysis of the mouse genome with special reference to the mouse chromosome 17 /." Lund : Dept. of Molecular Genetics, Institute of Genetics, University of Lund, 1992. http://books.google.com/books?id=JM1qAAAAMAAJ.

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McCutchan, Jennifer Susan. "Transferring ascochyta blight resistance from Lathyrus sp. into field pea (Pisum sativum L.) via protoplast fusion (somatic hybridisation) /." Connect to thesis, 2001. http://eprints.unimelb.edu.au/archive/00000696.

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Santos, Maria do Rosario N. dos. "Gene assignment: interspecific somatic cell hybridization." Thesis, 2015. http://hdl.handle.net/10539/17189.

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Shin, William Kihoon. "Systems Biology Approaches to The Study of Neurological Disorders and Somatic Cell Reprogramming." Thesis, 2016. https://doi.org/10.7916/D8CR5TV2.

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This thesis describes the development of an systems biology method to study transcriptional programs that are activated during early and late phases of cell-fusion mediated reprogramming, as well as an implementation of systems-level analysis using reverse-engineered regulatory networks to study CNS disorders like Alcohol Addiction, and neurodegenerative disorders like Alzheimer's Disease (AD), and Parkinson's Disease (PD). The results will show an unprecedented view into the mechanisms underlying complex processes and diseases, and will demonstrate the predictive power of these methodologies that extended far beyond their original contexts.
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Books on the topic "Somatic cell hybridization"

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Nachtrieb, Erik S. RAPD marker identification for confirmation of asymmetric somatic hybrids between Brassica oleracea and B. juncea. 1996.

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Ephrussi, Boris. Hybridization of Somatic Cells. Princeton University Press, 2015.

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Ephrussi, Boris. Hybridization of Somatic Cells. Princeton University Press, 2016.

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Ephrussi, Boris. Hybridization of Somatic Cells. Princeton University Press, 2015.

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Book chapters on the topic "Somatic cell hybridization"

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Sink, K. C., R. K. Jain, and J. B. Chowdhury. "Somatic Cell Hybridization." In Distant Hybridization of Crop Plants. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-84306-8_10.

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Bates, George W., Lawrence J. Nea, and Clare A. Hasenkampf. "Electrofusion and Plant Somatic Hybridization." In Cell Fusion. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4757-9598-1_24.

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Miller, Orlando J., and Eeva Therman. "Somatic Cell Hybridization in Cytogenetic Analysis." In Human Chromosomes. Springer New York, 2001. http://dx.doi.org/10.1007/978-1-4613-0139-4_23.

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Wang, G., and H. Binding. "Somatic Hybridization and Cell Grafting in Senecio." In Biotechnology in Agriculture and Forestry. Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-642-56758-2_22.

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Hamill, John D., and Edward C. Cocking. "Somatic Hybridization of Plants and its Use in Agriculture." In Plant Cell Biotechnology. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73157-0_3.

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Tomiczak, Karolina, Anna Mikuła, and Jan J. Rybczyński. "Protoplast Culture and Somatic Cell Hybridization of Gentians." In The Gentianaceae - Volume 2: Biotechnology and Applications. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-54102-5_7.

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Ryschka, U., G. Schumann, E. Klocke, P. Scholze, and R. Krämer. "Somatic Cell Hybridization for Transfer of Disease Resistance in Brassica." In Plant Biotechnology and In Vitro Biology in the 21st Century. Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4661-6_48.

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Bioukar, E. B., F. Straehli, K. H. Ng, and J. Deschatrette. "Somatic Cell Hybridization as a Tool for Genetic Analysis of Peroxisomal Activities." In Peroxisomes. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-87807-7_15.

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Smith, James R., and Olivia M. Pereira-Smith. "Dominance of In Vitro Senescence in Somatic Cell Hybridization and Biochemical Experiments." In The Jerusalem Symposia on Quantum Chemistry and Biochemistry. Springer Netherlands, 1985. http://dx.doi.org/10.1007/978-94-009-5466-3_14.

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"CHAPTER 7. Application of Cell Hybridization to the Study of Cancer." In Hybridization of Somatic Cells. Princeton University Press, 2015. http://dx.doi.org/10.1515/9781400868223-008.

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Conference papers on the topic "Somatic cell hybridization"

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Ploos van Amstel, J. K., A. L. van der Zanden, P. H. Reitsma, and R. M. Bertina. "RESTRICTION ANALYSIS AND SOUTHERN BLOTTING OF TOTAL HUMAN DNA REVEALS THE EXISTENCE OF MORE THAN ONE GENE HOMOLOGOUS WITH PROTEIN S cDNA." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644639.

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A deficiency in protein S, the cofactor of activated protein C, is associated with an increased risk for the development of venous thrombosis. It is inherited as an autosomal dominant disorder. To improve the detection of heterozygotes in affected families, we have started to search for restriction fragment length polymorphism (RFLP) in the protein S gene. This study revealed the existence of two genes containing sequences homologous to protein S cDNA.Three non-overlapping fragments of clone pSUL5, which codes for the carboxy-terminal part of protein S and contains the complete 3' untranslated region, were isolated and used as probes in search for RFLP of the protein S gene.Surprisingly the non-overlapping probes shared more than one hybridizing band. The hybridization took place under stringent assay conditions.This observation is contradictory to the intron-exon organization of a gene and suggests the existence of two genes, containing sequences homologous with pSUL5. Both genes could be assigned to chromosome 3 by mapping through somatic cell hybrids. Whether two functional protein S genes are present in the human genome remains to be established.
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Ploos van Amstel, J. K., A. L. van der Zanden, E. Bakker, P. H. Reitsma, and R. M. Bertina. "INDEPENDENT ISOLATION OF HUMAN PROTEIN S cDNA AND THE ASSIGNMENT OF THE GENE TO CHROMOSOME 3." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644638.

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Protein S is a vitamin K-dependent glycoprotein, that serves as a cofactor of activated protein C. A hereditary deficiency in protein S is associated with an increased risk for the development of venous thrombosis. The deficiency is inherited as an autosomal dominant trait. We isolated a cDNA coding for protein S and assigned its gene to chromosome 3.A human liver cDNA library in phage xgtll (complexity 1.2 × 106 , D. Stafford, Chapel Hill) was screened by using immuno-purifiedpolyclonal anti-protein S IgG as a probe. Approximately 1.5 x 10 recombinants of the amplified library were screened. Out of eighteen positive clones one clone was found, after nucleotide sequence analysis, to code for a peptide with a high degree of homology with the carboxy terminal region of the already published bovine protein S. This clone pSP84 (450 bp) was used as a probe to screen a human liver cDNA library in plasmid pUC9. From this library we isolated several positive clones. Clone pSUL5 contained the largest insert (2200 base pairs). Dideoxy sequencing revealed that it codes for 330 amino acids of the carboxy terminal part of protein S. Furthermore, it contained a 1200 base pairs 3' untranslated region. The predicted amino acid sequence did not differ from the published sequence of human protein S, although at the nucleotide level some differences could be detected.Clone pSUL5 was used to localize the protein S gene to its chromosome. The assignment was done by hybridization to Pst I digested DNA from human-hamster c.q. human-mouse somatic cell hybrids. In this way we got strong indication that the protein S gene is located on chromosome 3.
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