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Journal articles on the topic 'Somatomedin'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Dodson, M. V., B. A. Mathison, and K. L. Hossner. "Interaction of ovine somatomedin-C/IGF-I and IGF-I with specific IGF-I receptors on cultured muscle-derived fibroblasts." Acta Endocrinologica 116, no. 2 (1987): 186–92. http://dx.doi.org/10.1530/acta.0.1160186.

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Abstract. Binding of 125I-insulin-like growth factor-I and 125I-ovine somatomedin-C/IGF-I to monolayer cultures of muscle-derived ovine fibroblasts is described. Preliminary competitive binding experiments indicate that ovine fibroblasts possess independent cell surface receptors for IGF-I. Affinity of rIGF-II for IGF-I binding sites is minimal; rIGF-II binds to Type I IGF receptors at 1/1000 the strength of IGF-I. Insulin binds to the Type I IGF receptor at 1/100 the strength of IGF-I, whereas ovine somatomedin-C/IGF-I displays equivalent IGF-I binding as evidenced by overlapping competition

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2

Phillips, L. S., S. Goldstein, and J. R. Gavin. "Nutrition and somatomedin XVI: Somatomedins and somatomedin inhibitors in fasted and refed rats." Metabolism 37, no. 3 (1988): 209–16. http://dx.doi.org/10.1016/0026-0495(88)90097-2.

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3

UNTERMAN, LAWRENCE S., and STENVERT L. S. PHILLIPS. "Glucocorticoid Effects on Somatomedins and Somatomedin Inhibitors*." Journal of Clinical Endocrinology & Metabolism 61, no. 4 (1985): 618–26. http://dx.doi.org/10.1210/jcem-61-4-618.

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4

Phillips, Lawrence S., Vina R. Bajaj, Alan C. Fusco, Kim M. Keery, and Steven Goldstein. "Nutrition and somatomedin—XII. Fractionation of somatomedins and somatomedin inhibitors in normal and diabetic rats." International Journal of Biochemistry 17, no. 5 (1985): 597–603. http://dx.doi.org/10.1016/0020-711x(85)90291-5.

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5

Goldstein, S., and L. S. Phillips. "Nutrition and somatomedin: Nutritionally regulated release of somatomedins and somatomedin inhibitors from perfused livers in rats." Metabolism 38, no. 8 (1989): 745–52. http://dx.doi.org/10.1016/0026-0495(89)90060-7.

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6

Huybrechts, L. M., D. B. King, T. J. Lauterio, J. Marsh, and C. G. Scanes. "Plasma concentrations of somatomedin-C in hypophysectomized, dwarf and intact growing domestic fowl as determined by heterologous radioimmunoassay." Journal of Endocrinology 104, no. 2 (1985): 233–39. http://dx.doi.org/10.1677/joe.0.1040233.

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ABSTRACT The application of a human somatomedin-C radioimmunoassay for the determination of somatomedin-C in chicken plasma has been examined. Parallel inhibition of binding of 125I-labelled somatomedin-C to antisera raised against somatomedin-C was observed with acid-treated human and chicken plasma. The concentration of immunoreactive (IR)-somatomedin-C in the plasma of the domestic fowl appears to be GH dependent. Plasma concentrations of IR-somatomedin-C were reduced after hypophysectomy and partially restored by replacement therapy with chicken GH. The age/development pattern of circulati

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7

Pavelić, K., D. Vrbanec, S. Marušić, S. Levanat, and T. Čabrijan. "Autocrine tumour growth regulation by somatomedin C: an in-vitro model." Journal of Endocrinology 109, no. 2 (1986): 233–38. http://dx.doi.org/10.1677/joe.0.1090233.

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ABSTRACT A human primary haemangiosarcoma was derived from a patient with severe hypoglycaemia. Cell line established from that tumour secreted somatomedin C in serum-free culture media. Immunoreactive somatomedin from the media eluted from Sephacryl S-200 in two peaks of 160 000 and 8000 molecular weights. Similar results were obtained when medium was acidified and chromatographed on Sephadex G-50. Binding of tracer concentrations of 125I-labelled somatomedin C to human haemangiosarcoma cells was much higher than that of 125I-labelled insulin. Half-maximal displacement of 125I-labelled somato

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8

Phillips, Lawrence S., Alan C. Fusco, and Terry G. Unterman. "Nutrition and somatomedin. XIV. Altered levels of somatomedins and somatomedin inhibitors in rats with streptozotocin-induced diabetes." Metabolism 34, no. 8 (1985): 765–70. http://dx.doi.org/10.1016/0026-0495(85)90028-9.

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9

Ronge, H., J. Blum, C. Clement, F. Jans, H. Leuenberger, and H. Binder. "Somatomedin C in dairy cows related to energy and protein supply and to milk production." Animal Science 47, no. 2 (1988): 165–83. http://dx.doi.org/10.1017/s000335610000324x.

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ABSTRACTSomatomedin C and other hormones, as well as blood metabolites, were measured during the dry period and during lactation in dairy cows, given different amounts of energy and protein, to study metabolic and endocrine adaptations. Somatomedin C, specifically measured by radioimmunoassay after separation from its binding protein, did not exhibit typical diurnal variations, in contrast to somatotropin and insulin, which increased particularly after concentrate intake. Somatomedin C markedly decreased at parturition and reached lowest values around the peak of lactation, while levels of som

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10

Burch, W. M., and J. J. Van Wyk. "Triiodothyronine stimulates cartilage growth and maturation by different mechanisms." American Journal of Physiology-Endocrinology and Metabolism 252, no. 2 (1987): E176—E182. http://dx.doi.org/10.1152/ajpendo.1987.252.2.e176.

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The mechanisms by which triiodothyronine (T3) stimulates growth and maturation of growth-plate cartilage in vitro were studied by incubating embryonic chick pelvic cartilages in serum-free medium in the presence and absence of T3 for 3 days. To determine whether T3 might stimulate production of somatomedins by the cartilage, medium from cartilage incubated with and without T3 was assayed for somatomedin C (Sm-C) by radioimmunoassay. No difference in Sm-C content was found. However, cartilage incubated with T3 and increasing amounts of human Sm-C (0.5-20 ng/ml) weighed more and had greater amou

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11

Blum, Werner F., Michael B. Ranke, Brigitte Lechner, and Jürgen R. Bierich. "The polymorphic pattern of somatomedins during human development." Acta Endocrinologica 116, no. 4 (1987): 445–51. http://dx.doi.org/10.1530/acta.0.1160445.

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Abstract. Human somatomedins (Sm) are heterogeneous on separation by chromatofocussing. Besides the 'classic' insulin-like growth factor I and II (IGF-I/Sm-C and IGF-II), a number of minor peaks emerge which can be classified as IGF-I/Sm-C-like or as IGF-II-like. The aim of the current study was to investigate whether or not polymorphism of somatomedins is present in individuals and whether or not the polymorphic pattern changes during development. Serum extracts from normal healthy children and adults were fractionated by chromatofocussing and the various somatomedin-like peptides were quanti

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12

&NA;. "Somatomedin-1." Reactions Weekly &NA;, no. 768 (1999): 11. http://dx.doi.org/10.2165/00128415-199907680-00037.

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13

&NA;. "Somatomedin-1." Reactions Weekly &NA;, no. 566 (1995): 11. http://dx.doi.org/10.2165/00128415-199505660-00040.

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14

&NA;. "Somatomedin 1." Reactions Weekly &NA;, no. 528 (1994): 12. http://dx.doi.org/10.2165/00128415-199405280-00048.

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15

&NA;. "Somatomedin 1." Reactions Weekly &NA;, no. 529 (1994): 9. http://dx.doi.org/10.2165/00128415-199405290-00034.

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16

Morrell, D. J., K. P. Ray, A. T. Holder, et al. "Somatomedin C/insulin-like growth factor I: simplified purification procedure and biological activities of the purified growth factor." Journal of Endocrinology 110, no. 1 (1986): 151–58. http://dx.doi.org/10.1677/joe.0.1100151.

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ABSTRACT Human somatomedin C has been purified from Cohn fraction IV paste by a simplified procedure using chromatofocusing, hydroxylapatite chromatography and reverse-phase high performance chromatography. The purified material has a specific activity by somatomedin C radioimmunoassay of 9160 units/mg (1 unit is defined as the amount of somatomedin present in 1 ml normal adult male human serum), representing a 650 000-fold purification, and possesses sulphation, mitogenic and insulin-like activities (specific activities of 3388 units/mg, 832 units insulin equivalents/mg and 1122 units/mg resp

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17

Thiériot-Prévost, G., F. Daffos, and F. Forestier. "Serum somatomedin-C and bioassayable growth-promoting activity (thymidine activity) in appropriate and small-for-gestational-age human newborns." Acta Endocrinologica 110, no. 1 (1985): 32–35. http://dx.doi.org/10.1530/acta.0.1100032.

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Abstract. The serum level of radioimmunoassayable somatomedin-C and the bioassayable growth-promoting activity evaluated by the stimulating effect of serum upon thymidine incorporation into activated lymphocytes have been measured in the blood of term human foetuses. Comparison between those with a low birth weight and those with normal birth weight has shown that small-forgestational-age subjects have lower somatomedin-C (0.31 ± 0.03 vs 0.52 ± 0.03) and thymidine activity (1.03 ± 0.11 vs 1.50 ± 0.07) (P< 0.001). A positive correlation between somatomedin and thymidine activity was found. T

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18

Parkes, M. J., and D. J. Hill. "Lack of growth hormone-dependent somatomedins or growth retardation in hypophysectomized fetal lambs." Journal of Endocrinology 104, no. 2 (1985): 193–99. http://dx.doi.org/10.1677/joe.0.1040193.

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ABSTRACT Fetal lambs were hypophysectomized and, after 8 days of recovery, given infusions of GH, prolactin, thyroxine and insulin with glucose. Hypophysectomy caused no consistent reduction in fetal plasma somatomedin-like activity. Fetal infusions of GH or prolactin caused no consistent change in plasma somatomedin-like activity. It was concluded that fetal somatomedin-like activity is not GH dependent. After hypophysectomy fetal lambs showed no reduction in body weight or length at term. J. Endocr. (1985) 104, 193–199

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19

Biro, J. C., and P. Eneroth. "Effects of the uterus and the ovaries on growth, somatotrophin and somatomedin A in developing rats." Journal of Endocrinology 113, no. 1 (1987): 21–26. http://dx.doi.org/10.1677/joe.0.1130021.

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ABSTRACT The effects of hysterectomy and ovariectomy on plasma concentrations of GH, somatomedin A, TSH and thyroxine (T4) were studied in developing rats. Four groups of 24-day-old rats were ovariectomized, ovohysterectomized, hysterectomized or sham-operated. Their weights, lengths and plasma hormone concentrations were measured at 26, 43, 64, 78 and 92 days of age to investigate pre- and postpubertal differences caused by the uterus or ovaries. Plasma concentrations of the hormones examined showed a successive rise with time, but GH and somatomedin A concentrations rose mainly after the ope

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20

Losa, Marco, Reinhard Oeckler, Jochen Schopohl, O. Albrecht Müller, Julia Alba-Lopez, and Klaus von Werder. "Evaluation of selective transsphenoidal adenomectomy by endocrinological testing and somatomedin-C measurement in acromegaly." Journal of Neurosurgery 70, no. 4 (1989): 561–67. http://dx.doi.org/10.3171/jns.1989.70.4.0561.

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✓ A series of 29 previously untreated patients with acromegaly underwent transsphenoidal adenomectomy. Pre- and postoperative evaluation consisted of measuring growth hormone (GH) secretory dynamics during an oral glucose tolerance test (OGTT), the insulin hypoglycemia test, and the thyrotropin- and gonadotropin-releasing hormone (TRH/GnRH) test, and by obtaining the basal somatomedin-C level. After surgery, clinical and biochemical amelioration was achieved in all but two patients. In the whole group, basal GH and somatomedin-C levels decreased from a mean (± standard error of the mean) of 52

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21

Simonov, M., V. Vlizlo, and I. Petruh. "Plasma concentrations of insulin-like growth factor, triiodothyronine, thyroxine, and insulin in cows during different physiological states." Agricultural Science and Practice 3, no. 3 (2016): 17–21. http://dx.doi.org/10.15407/agrisp3.03.017.

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Aim. To investigate the plasma concentrations of insulin-like growth factor (IGF, somatomedin C), triiodothyronine, thyroxine and insulin in cows during prepartum and postpartum periods. Methods. Enzyme- linked immunosorbent assay, clinical and statistical methods. Results. It was demonstrated that the plasma concentration of IGF, triiodothyronine, thyroxine, and insulin is lower in postpartum cows compared to the interlactation ones. Strong positive correlation dependence (r = 0.7) between the levels of thyroxine and somatomedin C was found on the 2 nd –4 th day after calving. The plasma conc

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22

Goldstein, Steven, Terry G. Unterman, and Lawrence S. Phillips. "Nutrition and Somatomedin." Annals of Nutrition and Metabolism 31, no. 6 (1987): 367–77. http://dx.doi.org/10.1159/000177296.

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23

Ramadan, Wael, Ahmed Elsayed, Mariam Abu Alim, Ellie Abdi, and Medhat Kasem Abdel Razek. "The Influence of Ballistic Exercises on Growth, Somatomedin Hormones for Soccer Players." Open Access Macedonian Journal of Medical Sciences 10, A (2022): 1023–27. http://dx.doi.org/10.3889/oamjms.2022.9122.

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BACKGROUND: The sequence of exercise-induced hormonal changes demonstrates the quantification of training and competition loads and developing a sport-specific conditioning program. AIM: The present study investigates the impact of ballistic exercises on biochemical variables and the muscular ability of soccer players. METHODS: Participants were assigned randomly to two groups, including ten participants in each group, and underwent a pre- post-intervention test, including growth hormone, somatomedin hormone, triple jump, and wide jump. RESULTS: The experimental group showed a significant incr

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24

Unterman, Terry G., Richard M. Vazquez, Anthony J. Slas, Pamela A. Martyn, and Lawrence S. Phillips. "Nutrition and somatomedin. XIII. Usefulness of somatomedin-C in nutritional assessment." American Journal of Medicine 78, no. 2 (1985): 228–34. http://dx.doi.org/10.1016/0002-9343(85)90431-0.

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25

Goldstein, S., L. A. Stivaletta, and L. S. Phillips. "Separation of somatomedins and somatomedin inhibitors by size exclusion high-performance liquid chromatography." Journal of Chromatography B: Biomedical Sciences and Applications 339 (January 1985): 388–93. http://dx.doi.org/10.1016/s0378-4347(00)84668-x.

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26

Edén, Staffan, Bengt-Åke Bengtsson, Kerstin Albertsson-Wikland, et al. "Plasma growth hormone profile in acromegaly before and ten days after transsphenoidal surgery." Acta Endocrinologica 120, no. 1 (1989): 113–20. http://dx.doi.org/10.1530/acta.0.1200113.

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Abstract. Profiles of plasma GH, plasma somatomedin-C and serum PRL concentrations as well as serum GH response to iv TRH were determined in 11 patients with acromegaly before and 10 days after surgery. Blood for profile determinations was drawn from a peripheral vein with a continuous withdrawal pump changing the recipient tube at 30-min intervals. Before surgery all patients had high plasma GH concentrations with irregular peaks and somatomedin-C concentrations were elevated. The response to TRH was abnormal in 8 patients. Three patients had slightly elevated PRL concentrations and one had h

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27

Ranke, Michael B., Werner F. Blum, Frank Haug, et al. "Growth hormone, somatomedin levels and growth regulation in Turner's syndrome." Acta Endocrinologica 116, no. 2 (1987): 305–13. http://dx.doi.org/10.1530/acta.0.1160305.

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Abstract. In a total of 56 children and adolescents with Turner's syndrome (41 with karyotype 45,X) basal serum levels of somatomedin bioactivity, Sm-C/IGF-I (RIA), IGF II (RIA), GH response to arginine and GHRH (GRF(1-29)NH2), and spontaneous GH secretion during 5.5 h of deep sleep were determined in a cross-sectional manner. GH responses to GRF and arginine as well as IGF-II levels were found to be in the normal range. Levels of somatomedin bioactivity were higher than normal before a bone age of 10 years, in the low-normal range thereafter, and below normal in some patients. Levels of Sm-C/

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28

Le Roith, Derek, Carolyn Bondy, Shoshana Yakar, Jun-Li Liu, and Andrew Butler. "The Somatomedin Hypothesis: 2001." Endocrine Reviews 22, no. 1 (2001): 53–74. http://dx.doi.org/10.1210/edrv.22.1.0419.

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Abstract Since the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify the concept. Originally somatic growth was thought to be controlled by pituitary GH and mediated by circulating insulin-like growth factor-I (IGF-I, somatomedin C) expressed exclusively by the liver. With the discovery that IGF-I is produced by most, if not all, tissues, the role of autocrine/paracrine IGF-I vs. the circulating form has been hotly debated. Recent experiments using transgenic and gene-deletion technologies have attempted to answer these questi

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29

Sifianou, P. "Somatomedin C: In Memoriam." Hormone and Metabolic Research 24, no. 08 (1992): 403. http://dx.doi.org/10.1055/s-2007-1003345.

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30

Glaser, E. W., S. Goldstein, and L. S. Phillips. "Nutrition and Somatomedin: XVII. Circulating Somatomedin C During Treatment of Diabetic Ketoacidosis." Diabetes 36, no. 10 (1987): 1152–60. http://dx.doi.org/10.2337/diab.36.10.1152.

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31

SCHAAF, L., W. F. BLUM, K. KIETZMANN, et al. "Somatomedin binding protein and somatomedin C are reliable indicators of acromegalic activity." Acta Endocrinologica 120, no. 3_Suppl (1989): S78. http://dx.doi.org/10.1530/acta.0.120s078.

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32

Glaser, E. W., S. Goldstein, and L. S. Phillips. "Nutrition and somatomedin. XVII. Circulating somatomedin C during treatment of diabetic ketoacidosis." Diabetes 36, no. 10 (1987): 1152–60. http://dx.doi.org/10.2337/diabetes.36.10.1152.

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33

Wynn, P. C., M. C. Stuart, A. L. C. Wallace, A. C. Kirby, and E. F. Annison. "Influence of nutritional status on growth hormone-dependent circulating somatomedin-C activity in mature sheep." Journal of Endocrinology 130, no. 2 (1991): 313–20. http://dx.doi.org/10.1677/joe.0.1300313.

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ABSTRACT The effect of daily administration of ovine GH for a period of 4 weeks on somatomedin-C biological activity in plasma was investigated in mature Merino sheep fed a maintenance energy intake (low plane; LP) or 1·6 times this amount (high plane; HP). The GH treatment resulted in a significant (P < 0·05) increase in plasma GH levels in blood samples collected 23·5 h after each daily injection in both LP and HP groups. Plasma concentrations of somatomedin-C activity and insulin were significantly stimulated to a maximum level by the third GH injection and remained at this level for 7 d

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34

Hall, K., U. Hansson, G. Lundin, et al. "SERUM LEVELS OF SOMATOMEDINS AND SOMATOMEDIN BINDING PROTEIN IN PREGNANT WOMEN AND THEIR INFANTS." Pediatric Research 20, no. 11 (1986): 1192. http://dx.doi.org/10.1203/00006450-198611000-00112.

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35

Sheppard, M. S., and R. M. Bala. "Profile of serum immunoreactive insulin-like growth factor I during gestation in Wistar rats." Canadian Journal of Physiology and Pharmacology 64, no. 5 (1986): 521–24. http://dx.doi.org/10.1139/y86-086.

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It has been reported that there is a striking homology between the basic insulin-like growth factors (IGF) – somatomedins (SM) found in humans and rats. The radioimmunoassay (RIA) developed for the human hormone IGF-I (basic somatomedin, B-SM) can measure immunoreactive IGF-I in rat serum (IrIGF-I). Using this RIA, the profile of serum IrIGF-I was measured at each day of gestation in groups of inbred and Charles River Wistar rats. In each case IrIGF-I showed a gradual increase in early and mid gestation followed by a sharp decrease that occurred late in gestation to values 20–40% of control. T

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36

Geelhoed-Duijvestijn, P. H. L. M., J. K. Bussemaker, and F. Roelfsema. "Changes in basal and stimulated TSH and other parameters of thyroid function in acromegaly after transsphenoidal surgery." Acta Endocrinologica 121, no. 2 (1989): 207–15. http://dx.doi.org/10.1530/acta.0.1210207.

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Abstract. T4 and T3 levels, TSH response to TRH and somatomedin-C levels in 63 patients with acromegaly, were measured before transsphenoidal surgery and during a 4-year follow-up period. Criteria for cure were: mean GH level <5 mU/l, suppression of GH by oral glucose tolerance test below 2.5 mU/l and normalization of paradoxical GH reaction to TRH. Nine patients underwent radioiodine studies to assess the renal and thyroid clearance of iodide, plasma inorganic iodine level and absolute iodine uptake. Among the patients 40% had goitre, with a male preponderance. T4 and T3 levels were in the

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37

Thorlacius-Ussing, O., A. Flyvbjerg, K. Damm Jørgensen, and H. Ørskov. "Growth hormone restores normal growth in selenium-treated rats without increase in circulating somatomedin C." Acta Endocrinologica 117, no. 1 (1988): 65–72. http://dx.doi.org/10.1530/acta.0.1170065.

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Abstract. Selenium intake (5.0 ppm) induces growth retardation, accumulation of selenium in somatotrophs, lack of growth hormone response to GHRH and an 80 per cent reduction in serum somatomedin C in infant rats. In addition, it induces a slight reduction in serum albumin and occasionally slight central liver necrosis. In order to determine the role of insufficient growth hormone production, the influence of exogenous growth hormone was studied during selenium intake in groups of rats during 25 to 46 days of age (post-weaning). A dosage of human growth hormone (100 μg twice daily) was chosen,

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38

&NA;. "Somatomedin-1 binding protein-3." BioDrugs 17, no. 5 (2003): 375–79. http://dx.doi.org/10.2165/00063030-200317050-00008.

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39

Motokawa, Satoru, Tomoko Matsumoto, Takashi Hashiguchi, Yoshihiro Inoue, and Katsurou Iwasaki. "Somatomedin C in Perthes' disease." Orthopedics & Traumatology 37, no. 4 (1989): 1666–69. http://dx.doi.org/10.5035/nishiseisai.37.1666.

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40

Kaplan, Solomon A. "Somatomedin Hypothesis: Time for Reexamination." Endocrinologist 11, no. 6 (2001): 470–73. http://dx.doi.org/10.1097/00019616-200111000-00008.

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41

Laron, Zvi. "Clinical Use of Somatomedin-1." Pediatric Drugs 1, no. 3 (1999): 155–59. http://dx.doi.org/10.2165/00128072-199901030-00001.

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42

Loche, Sandro, Roberto Corda, and Carlo Pintor. "Sex steroids and somatomedin C." Journal of Pediatrics 109, no. 2 (1986): 395. http://dx.doi.org/10.1016/s0022-3476(86)80424-3.

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43

Hofert, John F., Steven Goldstein, and Lawrence S. Phillips. "Glucocorticoid effects on IGF-1/somatomedin-C and somatomedin inhibitor in streptozotocin-diabetic rats." Metabolism 38, no. 6 (1989): 594–600. http://dx.doi.org/10.1016/0026-0495(89)90224-2.

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44

Blum, Werner F., Michael B. Ranke, and Jürgen R. Bierich. "Isolation and partial characterization of six somatomedin-like peptides from human plasma Cohn fraction IV." Acta Endocrinologica 111, no. 2 (1986): 271–84. http://dx.doi.org/10.1530/acta.0.1110271.

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Abstract. Six somatomedin-like peptides were purified from human plasma Cohn fraction IV by a six-step procedure which included ethanol precipitation, reversed-phase extraction, gel filtration, chromatofocusing and reversed-phase high pressure liquid chromatography (HPLC). Purification was monitored with a competitive protein binding assay using a crude preparations of somatomedin carrier protein. The peptides isolated were homogeneous by reversed-phase HPLC and sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). Their apparent isoelectric points determined by chromatofocusi

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45

GIJSBERS, Rik, Hugo CEULEMANS, and Mathieu BOLLEN. "Functional characterization of the non-catalytic ectodomains of the nucleotide pyrophosphatase/phosphodiesterase NPP1." Biochemical Journal 371, no. 2 (2003): 321–30. http://dx.doi.org/10.1042/bj20021943.

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The ubiquitous nucleotide pyrophosphatases/phosphodiesterases NPP1–3 consist of a short intracellular N-terminal domain, a single transmembrane domain and a large extracellular part, comprising two somatomedin-B-like domains, a catalytic domain and a poorly defined C-terminal domain. We show here that the C-terminal domain of NPP1–3 is structurally related to a family of DNA/RNA non-specific endonucleases. However, none of the residues that are essential for catalysis by the endonucleases are conserved in NPP1–NPP3, suggesting that the nuclease-like domain of NPP1–3 does not represent a second

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46

Buyse, J., E. Decuypere, P. J. Sharp, L. M. Huybrechts, E. R. Kühn, and C. Whitehead. "Effect of corticosterone on circulating concentrations of corticosterone, prolactin, thyroid hormones and somatomedin C and on fattening in broilers selected for high or low fat content." Journal of Endocrinology 112, no. 2 (1987): 229–37. http://dx.doi.org/10.1677/joe.0.1120229.

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ABSTRACT Daily changes in the concentrations of plasma corticosterone, prolactin, thyroid hormones and somatomedin C were measured in 28-day-old fat and lean lines of broilers produced by selection for high and low concentrations of very low density lipoproteins (VLDL). The effects of daily injections of corticosterone on the concentrations of these hormones and on fattening were compared in the two lines. The selection procedure had no effect on the concentrations of any of the hormones. However, daily rhythms in concentrations of plasma corticosterone, tri-iodothyronine (T3) and prolactin we

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&NA;. "Somatomedin-1 shows potential in IDDM." Inpharma Weekly &NA;, no. 1110 (1997): 19. http://dx.doi.org/10.2165/00128413-199711100-00033.

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&NA;. "Potential anabolic effects with somatomedin-1." Inpharma Weekly &NA;, no. 877 (1993): 10. http://dx.doi.org/10.2165/00128413-199308770-00019.

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UNTERMAN, T. G., and L. S. PHILLIPS. "Circulating Somatomedin Activity during Hepatic Regeneration*." Endocrinology 119, no. 1 (1986): 185–92. http://dx.doi.org/10.1210/endo-119-1-185.

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McGraw, M. E., D. A. Price, and D. J. Hill. "Somatomedin C deficiency in Asian sisters." Archives of Disease in Childhood 61, no. 12 (1986): 1233–35. http://dx.doi.org/10.1136/adc.61.12.1233.

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