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Dissertations / Theses on the topic 'Somatostatin analog'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Li, Su-Chen. "Small Intestinal Neuroendocrine Tumor Analyses : Somatostatin Analog Effects and MicroRNA Profiling." Doctoral thesis, Uppsala universitet, Endokrin Onkologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233207.

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Small intestinal neuroendocrine tumors (SI-NETs) originate from serotonin-producing enterochromaffin (EC) cells in the intestinal mucosa. Somatostatin analogs (SSAs) are mainly used to control hormonal secretion and tumor growth. However, the molecular mechanisms leading to the control of SI-NETs are unknown. Although microRNAs (miRNAs) are post transcriptional regulators deeply studied in many cancers, are not well-defined in SI-NETs. We adopted a two-pronged strategy to investigate SSAs and miRNAs: first, to provide novel insights into how SSAs control NET cells, and second, to identify an e

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2

Verchere, Cameron Bruce. "Control of insulin secretion from the perfused rat pancreas : effects of acetylcholine and a somatostatin analog, SMS 201-995." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26657.

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The effect of varying concentrations of glucose or the gastrointestinal hormones, gastric inhibitory polypeptide (GIP) and somatostatin (SS-14), on the in vitro immunoreactive insulin (IRI) response to the parasympathetic neurotransmitter, acetylcholine (ACh) was investigated. The isolated, vascularly perfused rat pancreas was used in all experiments. Acetylcholine (1.0 µM) did not stimulate IRI secretion in the presence of 2.2 mM glucose. However, in the presence of 4.4, 6.6, or 8.9 mM glucose, ACh (1.0 µM) potently stimulated IRI secretion (approximately fourfold). At a higher glucose conce

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3

Assaka, Lucien. "Etude biochimique d'une (ou de) substances(s) immunologiquement apparentée(s) à la somatostatine chez l'escargot Helix aspersa : Corrélations avec la croissance et la regénération de la coquille." Besançon, 1988. http://www.theses.fr/1988BESA2022.

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Mise en evidence par immunocytochimie d'une substance analogue a la somatostatine dans le cerveau, l'hepatopancreas et le bord du manteau d. H. A. Des techniques biochimiques complementaires montrent l'existence de plusieurs substances differentes. La quantite de ces substances est plus elevee chez les animaux juveniles et a croissance lente, surtout localisees a l'hepatopancreas. Ces substances sont un relais ou un facteur de regulation de la croissance et de la regeneration de la coquille

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4

Cheng, Zhen. "Rhenium cyclized [alpha]-MSH analogs, somatostatin analogs and T-antigen avid peptides as imaging and therapeutic agents for tumor targeting /." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3012959.

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5

Morange, Isabelle. "Etude de l'efficacite et de la tolerance d'un analogue retard de la somatostatine (somatuline) dans l'acromegalie evolutive." Aix-Marseille 2, 1992. http://www.theses.fr/1992AIX20833.

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6

Rouah, Rosilio Myriam. "Traitement au long cours de l'acromegalie par la sandostatine." Aix-Marseille 2, 1990. http://www.theses.fr/1990AIX20816.

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7

BABIN, THIERRY. "Traitement de l'acromegalie par un analogue de la somatostatine, la sms 201-995, administratree en injection sous-cutanee continue." Toulouse 3, 1988. http://www.theses.fr/1988TOU31174.

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8

ROUX, LAURENCE. "Place actuelle de la sandostatine dans le traitement de l'acromegalie : a propos de 10 cas." Besançon, 1992. http://www.theses.fr/1992BESA3094.

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9

Ginj, Mihaela. "Design, synthesis and evaluation of somatostatin analogs for improved imaging and radionuclide therapy /." Basel : [s.n.], 2005. http://edoc.unibas.ch/diss/DissB_7345.

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10

Plöckinger, Ursula. "Akromegalie." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2001. http://dx.doi.org/10.18452/13753.

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Die Akromegalie - Folge eines Wachstumshormon (STH) sezernierenden Hypophysentumors - ist eine seltene Erkrankung. Bei früher Diagnose ist die Akromegalie gut behandelbar. Unbehandelt - oder zu spät behandelt - führt sie zu hoher Co-Morbidität und verkürzt das Leben. Endokrinologische Therapieziele wurden kürzlich definiert: Heilung bei STH<br>Acromegaly, caused by a growth hormone (GH)-secreting pituitary adenoma, is a rare disease. If diagnosed early therapeutic results are good. However, untreated or treated belatedly, acromegaly is associated with a high co-morbidity and reduced life-expec

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11

LE, POMMELET CHRISTOPHE. "Sandostatine et bromocriptine dans l'acromegalie." Aix-Marseille 2, 1992. http://www.theses.fr/1992AIX20840.

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12

VITON, LESCHELLE CAROLINE. "Effet d'un analogue de la somatostatine sur la fonction somatotrophe et la retinopathie du diabetique." Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX20808.

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13

BAILACQ, CHOISNARD MAYLIS. "Adenomes hypophysaires non fonctionnels et sandostatine* : a propos de 8 observations." Besançon, 1994. http://www.theses.fr/1994BESA3043.

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14

Bétoin, Florence. "Mise en évidence de l'effet antinociceptif du vapréotide, un analogique de la somatostatine, et étude de son mécanisme d'action." Clermont-Ferrand 1, 1993. http://www.theses.fr/1993CLF11005.

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15

Kamra, Kajal. "Effect of Administration of Somatostatin Analogue on Blood Pressure in Chronic Intermittent Hypoxic Rats." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright155791784103344.

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16

Kelleman, Audrey. "Design and syntheses of nonnatural amino acids and their incorporation into somatostatin and RGD analogs." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3249664.

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Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed April 3, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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17

Matarín, Morales Joan Antoni. "Syntheses of (S)-Bicalutamide and Somatostatin analogs, and development of Green procedures for Peptide synthesis." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673027.

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Peptides are defined as compounds that contain between two and fifty amino acids connected together by amide bonds. Inside our body, peptides are natural biological messengers that play critical roles in human physiology as hormones, neurotransmitters, growth factors or antibacterial agents. Since the first efforts on peptide synthesis circa 1900 and the introduction of cleavable protecting groups (PGs), the real breakthrough in the field was the concept of solid-phase peptide synthesis (SPPS) reported by B. Merrifield in 1963. This strategy conceived the use of a polymeric insoluble resin to

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18

Andrieu, Jean-Michel. "Traitement de l'acromégalie : efficacité endocrinienne et tolérance des analogues de la somatostatine." Montpellier 1, 1996. http://www.theses.fr/1996MON11112.

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19

LOCARD, BISOT SEGOLENE. "Effet d'un analogue de la somatostatine sur la taille des adenomes somatotropes." Lyon 1, 1991. http://www.theses.fr/1991LYO1M108.

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20

Martín-Gago, Pablo. "Synthesis of Highly Structured and Receptor-Selective Tetradecapeptidic Analogs of Somatostatin: Fine-tuning the non-covalent interactions among their aromatic residues." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/128565.

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Somatostatin, a peptidic hormone also known as somatotropin release-inhibiting factor (SRIF), is implicated in multiple biological functions, mediated by direct interaction of the peptide with a family of structurally related, G-protein coupled transmembrane receptors (GPCRs), named SSTR1-5. However, the full therapeutic potential of SRIF cannot be further exploited owing to its short half-life of <3 min in plasma and its lack of selectivity against all receptors. With the aim to overcome these limitations, many SRIF analogs containing key modifications have been synthesized over recent decade

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21

Duarte, Felipe Henning Gaia. "Síndrome da apnéia do sono na acromegalia: impacto do tratamento sobre o metabolismo dos carboidratos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-19092011-152108/.

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Introdução: A acromegalia é uma doença rara, caracterizada pela produção aumentada de hormônio do crescimento, causada geralmente por um adenoma hipofisário, ocasionando uma série de comorbidades como apneia do sono e resistência insulínica que acarretam um aumento na mortalidade e redução da expectativa de vida. Objetivo: O objetivo deste estudo foi avaliar o impacto da terapêutica da apneia do sono com um dispositivo de pressão positiva contínuas nas vias aéreas (CPAP) e avaliar o impacto desta terapêutica na resistência insulínica pela realização do clamp euglicêmico hiperinsulinêmico (CEH)

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22

Tomassoni, Federica <1972&gt. "Valutazione quantitativa dei recettori della somatostatina in tumori neuroendocrini e loro valutazione funzionale mediante nuovi analoghi della somatostatina in modelli cellulari." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/482/1/Tesi_Tomassoni_Federica.pdf.

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23

Tomassoni, Federica <1972&gt. "Valutazione quantitativa dei recettori della somatostatina in tumori neuroendocrini e loro valutazione funzionale mediante nuovi analoghi della somatostatina in modelli cellulari." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/482/.

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24

JOUDET, GUSTHIOT BEATRICE. "Traitement de l'acromegalie par les analogues de la somatostatine : etude comparative du lantreotide-retard (bim 23-104-retard) et de l'octreotide (sms 201-995) : a propos de 18 cas." Toulouse 3, 1994. http://www.theses.fr/1994TOU31541.

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25

DOHIN, CAPLANNE SYLVIE. "Shunts arterio-veineux intra-pulmonaires au cours de la cirrhose : bilan fonctionnel et tentative de fermeture par un analogue a longue duree d'action de la stomatostatine (sms 201-995)." Lille 2, 1991. http://www.theses.fr/1991LIL2M095.

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26

Jie, Bai. "Effets d'un analogue de la somatostatine, l'octréotide sur la pathogénicité à court et long termes de l'infection par Cryptosporidium parvum dans un modèle de raton nouveau-né immunocompétent." Rouen, 2011. http://www.theses.fr/2011ROUENR03.

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Le syndrome de l'intestin irritable post-infectieux (SU-PI) est décrit comme survenant après des épisodes de gastro-entérite aiguë telles qu'une infection par Cryptosporidium parvum. Les mécanismes physiopathologiques du SII comprennent une hypersensibilité viscérale, une activation persistante des réponses immunitaires intestinales muqueuses, une hyperplasie des cellules entérochromaffines et des mastocytes, et des changements fonctionnels ou structurels du système nerveux entérique. Notre objectif était d'étudier les effets d'un analogue agoniste de la somatostatine, l'octréotide, sur l'hype

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27

Guliana, Jean-Michel. "Hormonotherapie du cancer medullaire de la thyroide par un analogue de la somatostatine." Paris 6, 1990. http://www.theses.fr/1990PA066154.

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Le cancer medullaire de la thyroide (cmt) est une affection polymorphe, potentiellement hereditaire, secretant une hormone, la calcitonine (ct), par l'expression d'un gene qui, alternativement, peut conduire la synthese d'une autre molecule, le peptide alternatif du gene de la calcitonine (pagc). Le taux circulant de la ct a une valeur diagnostique et pronostique dans l'evolution des cmt. La dedifferenciation des cmt murins et des lignees cellulaires de cmt humain s'accompagne d'alterations de l'expression genomique et de la synthese de ct associant une diminution de l'expression du gene de la

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28

IGLICKI, FRANCK. "Comparaison de la sandostatine et de la sclerose endoscopique dans la prevention des recidives precoces par rupture de varices oesophagiennes chez le cirrhotique." Amiens, 1992. http://www.theses.fr/1992AMIEM102.

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29

Prasad, Vikas [Verfasser]. "Radiolabeled Somatostatin receptor analogs in neuroendocrine tumor : novel applications and clinical indications for in-vivo tumor characterization / Vikas Prasad." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1155761049/34.

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30

Renaud, Hélène. "Evolution exceptionnelle d'une tumeur carcinoi͏̈de digestive avec métastases hépatiques : une survie de 25 ans." Montpellier 1, 1996. http://www.theses.fr/1996MON11069.

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31

Malkinson, John Paul. "Lipoamino acid- and glycolipid-based peptide delivery system for somatostatin analogue TT-232 with anti-tumour activity." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392401.

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32

BISMUTH, LE BOT EVELYNE. "Effet sur l'appareil hepato-biliaire d'un analogue de la somatostatine a longue duree d'action : sms 201-995 ou sandostatine : resultats d'une etude controlee en double insu utilisant la cholescintigraphie quantitative." Nice, 1988. http://www.theses.fr/1988NICE6538.

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33

Bresch, Lena Mirjam [Verfasser], Dirk [Akademischer Betreuer] Raddatz, Kia [Gutachter] Homayounfar, and Hans-Ulrich [Gutachter] Schildhaus. "Effekte der Therapie mit Somatostatin-Analoga bei neuroendokrinen Tumoren / Lena Mirjam Bresch. Betreuer: Dirk Raddatz. Gutachter: Kia Homayounfar ; Hans-Ulrich Schildhaus." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://d-nb.info/1110148003/34.

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34

LOUIS-ALEXANDRE, SACRAMENTO REBECCA. "Le traitement de la grande taille familiale de l'adolescente : etude comparative de l'efficacite et de la tolerance de la sandostatine et de l'ethinyl oestradiol : a propos de 21 observations." Toulouse 3, 1994. http://www.theses.fr/1994TOU31127.

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35

AMARU', JESSICA. "Fisiopatologia dei recettori della somatostatina nei tumori ipofisari GH-secernenti." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1046906.

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First-generation somatostatin receptor ligands (fg-SRLs), such as octreotide (OCT), represent the first-line medical therapy in acromegaly. Fg-SRLs show a preferential binding affinity for somatostatin receptor subtype-2 (SST2), while the second-generation ligand, pasireotide (PAS), has high affinity for multiple SSTs (SST5 > SST2 > SST3 > SST1). Whether PAS acts via SST2 in somatotroph tumors, or through other SSTs (e.g., SST5), is a matter of debate. In this light, the combined treatment OCT+PAS could result in additive/synergistic effects. We evaluated the efficacy of OCT and PAS (

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36

Bonner, Grady Gregg 1965. "Synthesis, pharmacology, and structural analysis of opioid peptides: Cyclic somatostatin analogs which include unusual amino acids with conformationally restricted side-chain groups." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282318.

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This work relates the activities of Somatostatin-derived opioid peptides to their 3-dimensional structures. Due to the flexability of peptides, they adopt multiple conformations. This flexibility leads to ambiguity in the development of structure-activity profiles. Here flexibility is reduced by incorporation of amino acids with conformationally restricted side-chain groups. These groups are restricted to certain topographies by cyclization or biased through substitution at the beta carbon. The opioid activities of these peptides are determined by brain binding radioligand competition assay, i

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37

Barjon, Jean-Noël. "Syndrome chiasmatique des macroadénomes hypophysaires cliniquement non sécrétants : effet favorable du traitement par octreotide, analogue de longue durée d'action de la somatostatine : à propos de 11 observations." Montpellier 1, 1990. http://www.theses.fr/1990MON11071.

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38

CHEVALLIER, DEVAUD FRANCOISE. "Traitement de l'acromegalie par la somatostatine de synthese (sandostatine*) : evaluation prospective de l'efficacite et de la tolerance sur 58 cas ; etude multicentrique francaise sms-201-995." Nantes, 1990. http://www.theses.fr/1990NANT148M.

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39

Winkelmann, Moritz [Verfasser], and Günter Karl [Akademischer Betreuer] Stalla. "Evidence for better response to somatostatin analogue treatment in acromegalic patients treated with metformin / Moritz Winkelmann ; Betreuer: Günter Karl Stalla." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1189584832/34.

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40

Ezan, Éric. "Analogues de peptides hypothalamiques : radioimmunodosages et aspects pharmacocinétiques." Paris 5, 1989. http://www.theses.fr/1989PA05P616.

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41

Norlén, Olov. "Small Intestinal Neuroendocrine Tumor : A Rare Malignancy with Favorable Outcome." Doctoral thesis, Uppsala universitet, Endokrinkirurgi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-185071.

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Small intestinal neuroendocrine tumor (SI-NET) is the most common small bowel tumor in Europe and USA, with an annual incidence of around 0.3-1.3/100000 persons. SI-NETs are the most common type of gastroenteropancreatic NETs (GEP-NETs), and they are known for their ability to produce hormones such as tachykinins and serotonin, as well as for their favorable long-term prognosis in comparison to gastrointestinal adenocarcinoma. The overall aim of the thesis was to investigate unknown or unclear aspects of SI-NET disease, in connection with prognosis, treatment and follow-up. Paper I confirmed s

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42

Berger, Virginie. "Etude animale et clinique de l'effet antalgique du vapréotide, un analogue de la somatostatine : contribution méthodologique aux essais des antalgiques chez le volontaire sain." Clermont-Ferrand 1, 1998. http://www.theses.fr/1998CLF1MM11.

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Le vapréotide, analogue de la somatostatine, est un peptide de synthèse en cours de développement clinique, dans les indications habituelles de l'hormone native et plus particulièrement pour ses propriétés antisécrétoires et antiprolifératives. Cet analogue possède également des propriétés antinociceptives. L'étude de ces propriétés chez le rat sain ou modèles de douleur neurogène (rat mononeuropathique et rat diabétique) et inflammatoire (rat "carragénine" et rat polyarthritique) a été réalisée. Le vapréotide exerce une action centrale, comportant une composante spinale directe et/ou indirect

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43

Fjällskog, Marie-Louise. "Current Medical Treatment of Endocrine Pancreatic Tumors and Future Aspects." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2709.

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<p>We treated 16 patients with somatostatin analogs combined with α-interferon and achieved a biochemical and/or radiological response in 56% (median duration 22 months). We consider this treatment a good alternative for patients who fail during chemotherapy or who do not want to/cannot receive cytotoxic drugs.</p><p>Thirty-six patients with neuroendocrine tumors were treated with cisplatin combined with etoposide. Of 14 patients with evaluable EPTs, 50% responded radiologically and/or biochemically (median duration 9 months). We consider this treatment useful as first-line medical treatment i

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44

Bhayana, Shelly. "The implication of somatotroph adenoma phenotype to somatostatin analog responsiveness in acromegaly." 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=450582&T=F.

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45

Pin, Pan Chia, and 潘家檳. "Solution structure determination of somatostatin analog and synthetic a-helical peptide using 2D NMR and molecular modelling." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/45961391219905423270.

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46

Bresch, Lena Mirjam. "Effekte der Therapie mit Somatostatin-Analoga bei neuroendokrinen Tumoren." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-0028-87B8-5.

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In der vorliegenden retrospektiven Analyse wurden die Daten von 66 Patienten, die an einem NET erkrankt und in der Universitätsmedizin Göttingen behandelt wurden, bezüglich der Ef-fekte der Therapie mit SAA statistisch aufgearbeitet, ausgewertet und die erhaltenen Daten anhand der aktuellen Literatur diskutiert. Ziel war es, die in vorherigen Studien beobachtete verlängerte Dauer der stable disease unter der Therapie mit SAA auch in unserem Patientenkollektiv nachzuweisen. Ein zusätzliches Au-genmerk lag auf weiteren Effekten der Therapie mit SAA: Verlauf der Tumormarker und der Symptomatik so

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47

Krebs-Schmitt, Dorothee [Verfasser]. "Charakterisierung antiproliferativer Effekte von Somatostatin-Analoga in hepatozellulären Karzinomzellen / vorgelegt von Dorothee Krebs-Schmitt." 2007. http://d-nb.info/986486388/34.

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48

TRAPANI, Silvia. "Gli analoghi della somatostatina nel trattamento dell’epatocarcinoma in stadio avanzato." Doctoral thesis, 2012. http://hdl.handle.net/11573/505722.

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BACKGROUND: Il trattamento con la somatostatina ed i suoi analoghi long-acting potrebbe rappresentare un’opportunità terapeutica per quei pazienti con tumore primitivo del fegato in stadio avanzato per le sue provate proprietà antiproliferative e pro-apoptotiche. L’azione di questi farmaci è mediata da specifici recettori espressi sulla membrana plasmatica delle cellule neoplastiche. OBIETTIVI DELLO STUDIO: Valutare 1) la frequenza della espressione dei recettori per la somatostatina nei noduli di HCC mediante scintigrafia con octreotide marcata (OCTREOSCAN®), tecniche immunoistochimiche e do

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TRAPANI, SILVIA. "GGli analoghi della somatostatina nel trattamento dell'epatocarcinoma in stadio avanzato." Doctoral thesis, 2012. http://hdl.handle.net/11573/917759.

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50

Drückler, Ulrike [Verfasser]. "Entwicklung neuer radioaktiv markierbarer pan-Somatostatin-Analoga zur nuklearmedizinischen Diagnostik und Therapie / vorgelegt von Ulrike Drückler." 2007. http://d-nb.info/984658602/34.

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