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Dissertations / Theses on the topic 'Somatotroph'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Gilbert, Tanya. "Somatotroph regulation in dwarf rats." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322764.

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2

Rawlings, Stephen Roy. "Intracellular mechanisms regulating growth hormone release from the bovine somatotroph." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315241.

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3

Waite, Eleanor Jane. "Viral ion channel disruption of the somatotroph population in transgenic mice." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1446152/.

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Spontaneous and induced murine genetic models of disrupted somatotroph function have been useful in elucidating their relationships with other pituitary cell types as well as in studying downstream effects of GH deficiency. To disrupt somatotroph cell function in a temporally controlled fashion, I have applied a transgenic ion-channel conditional ablation strategy. The H37A variant of the influenza virus M2 protein that conducts monovalent cations unless blocked with the anti-influenza drug Rimantadine. This channel, previously shown to ablate GHRH neurons, has been targeted to somatotrophs us

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4

Thapar, Kamal. "Accumulation of hypophysiotropic hormone mRNAs in somatotroph pituitary tumors, biological, clinical and prognostic implications." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0022/NQ49927.pdf.

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5

Sondergaard, Jeffrey, Kyle Rice, Kira Weaver, Devin Josey, Taylor Gregory, and Christie Monahan. "Comparison Of Two Rat Somatotroph Cell Lines To Examine Tissue-Specific Transcription Of Growth Hormone." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/185.

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Growth Hormone (GH), also known as somatotrophin, is of cardinal importance in the regulation of somatic growth. Decreased GH expression results in short stature, whereas increased levels of GH lead to disorders such as gigantism or acromegaly. Mutations in the transcription factor Pit-1 have been shown to decrease GH, as well as prolactin (PRL; Parks et al., JCEM, 1999). However, understanding the regulation by selective GH transcription regulators, such as Zn16, a protein encoding 16 zinc fingers that binds to the GH promotor DNA (Wojtkiewicz et al., Endocrine, 2002), will require comparison

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6

Deeb, Asma. "The regulation of somatotroph function by growth hormone releasing hormone and its receptor in vitro." Thesis, University of Newcastle upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246715.

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7

Gregory, Taylor, Devin Josey, Alexa Bancroft, et al. "RNA-Seq to analyze two related rat Growth Hormone-producing somatotroph cell lines for tissue-specific transcript expression." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/154.

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Growth Hormone (GH), also known as somatotropin, is a protein hormone secreted from the anterior pituitary gland. GH action results in longitudinal bone growth in children and adolescents and continues later to control a variety of metabolic reactions in adults. DNA polymorphisms leading to a decrease in GH expression result in persons of short stature, whereas those leading to overexpression of GH produce either acromegaly or gigantism. In order to diagnose and treat patients with altered GH production, understanding the control of GH expression is thus clinically relevant. In order to un

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8

Mear, Yves. "Implication de l'activité constitutive du récepteur de la ghréline dans la tumorigenèse des adénomes somatotropes." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5102.

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Les adénomes hypophysaires sont les tumeurs intracérébrales les plus fréquentes. Les adénomes somatotropes hypersécrètent l’hormone de croissance (GH) et sont traités classiquement par des analogues somatostatinergiques. Une petite moitié des patients acromégales est néanmoins résistante à ces traitements. L’on sait depuis, quelques années, que le récepteur de la ghréline possède une forte activité constitutive et joue un rôle majeur dans la sécrétion de GH. Cette activité constitutive est-elle impliquée dans la tumorigenèse des adénomes somatotropes ? Nos travaux ont montré un niveau de trans

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9

Graillon, Thomas. "Etudes des voies somatostatinergiques et Pi3Kinase-Akt-mTOR dans les tumeurs intra-crâniennes (Adénomes hypophysaires, Méningiomes, Chordomes)." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5053.

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1. Adénomes hypophysaires somatotropes : Elaboration d'un modèle in vitro et in vivo d'études du récepteur SST2 et des voies de signalisation somatostatinergiques.Afin de préciser l'étude du récepteur SST2, nous avons mis en place un modèle d'étude in vitro et in vivo, en établissant une lignée polyclonale exprimant le récepteur SST2 humain à de hauts niveaux. Ce modèle nous permettra de tester de nouveaux agonistes somatostatinergiques comme le pasiréotide et d'étudier de façon approfondie les voies de signalisation.2. Méningiomes : Mise en place d'un modèle de culture primaire de méningiome

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10

Ogawa, Shuichiro. "Abundant expression of the membrane-anchored protease-regulator RECK in the anterior pituitary gland and its implication in the growth hormone/insulin-like growth factor 1 axis in mice." Kyoto University, 2020. http://hdl.handle.net/2433/254494.

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11

Pullar, Rebecca Ann. "Studies on bovine somatotropin." Thesis, University of Reading, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304645.

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12

Decourtye, Lyvianne. "Impact de la nutrition périnatale sur la mise en place de l'axe somatotrope." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066317/document.

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La nutrition au cours de la période postnatale précoce programme l’activité de l’axe somatotrope à l’âge adulte (GH/IGF-1). Une altération de la nutrition chez les souriceaux au cours de la lactation altère la croissance staturo-pondérale de façon permanente et augmente leurs susceptibilités à développer des pathologies cardio-métaboliques à l’âge adulte. La restriction au cours de la lactation induit une diminution des taux plasmatiques en IGF-1 et en leptine. Ceci est associé à une diminution transitoire de l’innervation de l’éminence médiane par les neurones GHRH, ce qui induit une hypoplas

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13

Wurmser, Marc. "Le traitement de l'insuffisance somatotrope par l'hormone de croissance humaine : premiers resultats a propos de vingt-deux observations." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR1M097.

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14

Parkinson-Lawrence, Emma Jane. "Characterisation of intermediate(s) in the folding pathway of porcine growth hormone /." Title page, table of contents and summary only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09php2476.pdf.

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15

Ditte, Luc. "Du statut de l'hormone somatotrope chez la personne agee escarrifiee." Lille 2, 1994. http://www.theses.fr/1994LIL2M163.

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16

Raynaud, Mounet Nathalie. "Exploration de la fonction somatotrope de 23 enfants insuffisants renaux chroniques." Toulouse 3, 1990. http://www.theses.fr/1990TOU31548.

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17

Staniar, William Burton. "Growth and the Somatotropic Axis in Young Thoroughbreds." Diss., Virginia Tech, 2002. http://hdl.handle.net/10919/26273.

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This group of experiments focused on relationships between diet, somatotropic axis, and growth. Growth hormone (GH) and insulin-like growth factor I (IGF-I) are factors in the somatotropic axis, and important to development of growth cartilage in the young animal. The entire study was divided into four main experiments. Characteristics of growth in 113 Thoroughbred foals born over a five year period were described with a series of empirical and physiological equations. Glycemic and insulinemic responses to different feed compositions were evaluated with glycemic response tests. The 24 hr

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18

Vize, Peter Darren. "Expression of porcine growth hormone in bacteria and transgenic animals." Title page, contents and summary only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phv864.pdf.

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19

Régnier, Alain. "Quelques aspects de l'exploration clinique de la sécrétion somatotrope chez le chien." Toulouse, INPT, 1993. http://www.theses.fr/1993INPT023A.

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Des aspects pratiques de l'exploration clinique de la secretion somatotrope du chien ont ete abordes. Afin de developper un test de stimulation a la somatocrinine (ghrh) l'activite biologique des ghrh 1-44 et 1-29 d'origine humaine a ete evaluee chez le chien sain. En complement, l'interet diagnostique d'un test de stimulation associant le ghrh et le propranolol a ete etudie. Enfin, il a ete recherche si les conditions de conservation des prelevements de sang total ou de plasma pouvaient modifier la concentration de l'hormone de croissance canine mesuree par radioimmunologie. Parallelement, no

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20

Stehr, Katja [Verfasser]. "Veränderungen der Somatotrophen Achse bei Dilatativer Kardiomyopathie / Katja Stehr." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023464551/34.

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21

TASSO, MICHELE. "Etude de la reponse au traitement par l'hormone de croissance chez 116 enfants presentant un deficit somatotrope idiopathique : recherche de criteres cliniques, biologiques et therapeutiques predictifs de cette reponse." Toulouse 3, 1992. http://www.theses.fr/1992TOU31081.

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22

Bertin, Patrice. "Traitement de l'insuffisance somatotrope par l'hormone de croissance : etude retrospective sur une serie de 49 enfants." Reims, 1993. http://www.theses.fr/1993REIMM038.

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23

DEISS, GERALDINE. "Optimisation du cycle de lyophilisation de l'hormone de croissance." Strasbourg 1, 1993. http://www.theses.fr/1993STR15046.

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24

Iliev, Daniel. "Structural analysis of human growth hormone with respect to the dominant expression of GH mutations in isolated growth hormone deficiency type II." [S.l. : s.n.], 2005. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11947851.

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25

Sullivan, James Lawrence 1965. "Factors affecting response of cows to recombinant methionyl bovine somatotropin." Thesis, The University of Arizona, 1989. http://hdl.handle.net/10150/292276.

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Eighty lactating Holstein cows were randomly assigned to one of two treatments: Placebo(C) or 500 mg recombinant methionyl bovine somatotropin (BST). Cows were intramuscularly injected with C or BST every 14 d for 36 wk beginning 60 d postpartum. Factors analyzed for differences in milk yield response to BST included: production level, genetic potential, stage of lactation, and heat stress. Response of low producing cows to BST was numerically greater than that of medium or high producers (averaging 27%, 13%, and 20%, respectively, above controls). However, there was not a significant interact

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26

Adoutte, Danielle. "Sexually dimorphic effects of aging on the rat somatotrophic axis /." [S.l.] : [s.n.], 1992. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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27

Stennes, Bradley Kenneth. "Bovine somatotropin and the Canadian dairy industry : an economic analysis." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/42012.

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Bovine Somatotropin (BST) is a naturally occurring hormone in dairy cows which affects milk production levels (Chalupa and Galligan, 1988). The effects of BST have been known since the 1930's but limited supply of this hormone made any large scale commercial use impossible. Recently a low cost source of BST became available through recombinant DNA technology. This low cost availability of the hormone has led to research experiments which show that recombinant BST can significantly increase a cow's ability to produce milk (Peel and Bauman, 1987; Burton et al, 1987; Soderholm et al, 198

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28

Smallwood, Sébastien. "La leptine : rôle physiologique dans la fonction somatotrope, transduction du signal et mécanismes d'internalisation." Phd thesis, Université Claude Bernard - Lyon I, 2007. http://tel.archives-ouvertes.fr/tel-00143545.

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La leptine est une hormone adipocytaire impliquée notamment dans le contrôle de la balance énergétique et de la sécrétion d'hormone de croissance (GH). Ses récepteurs ObRa et ObRb sont exprimés dans les cellules somatotropes de rat, et elle régule l'expression hypophysaire du récepteur de la ghréline. Dans notre modèle de rats obèses DIO, l'altération des taux plasmatiques de GH caractéristique de cette pathologie n'est pas liée à la résistance hypophysaire à la leptine. Chez les rats Lou/C, la GH participe à la résistance à l'obésité, les hormones ghréline et leptine jouant un rôle prépondéra

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29

Spangler, Lothar. "Untersuchungen zum Einfluss nahezu kohlenhydratfreier, fettreicher Diäten auf die somatotrope Achse bei der Ratte." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-167573.

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30

Jouanin, Nancy. "Les modulateurs intra-ovariens : intérêt clinique des facteurs de croissance et de l'hormone somatotrope." Paris 5, 1994. http://www.theses.fr/1994PA05P059.

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31

Barlier, Anne. "Altérations des mécanismes de transduction et étoipathogénie des adénomes somatotropes humains." Aix-Marseille 2, 1998. http://www.theses.fr/1998AIX2664U.

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32

CATALA, BRIGITTE. "Resultats du traitement par hormone de croissance chez les enfants turneriennes." Clermont-Ferrand 1, 1991. http://www.theses.fr/1991CLF13038.

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33

SALVATI, MITAINE CAROLE. "L'hormone de croissance et la prolactine dans la depression." Nice, 1988. http://www.theses.fr/1988NICE6045.

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34

MORIN, CHANTAL. "Resultats a long terme des traitements par l'hormone de croissance : a propos de 84 cas." Toulouse 3, 1992. http://www.theses.fr/1992TOU31078.

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35

ZEMZARI, MEJDA. "Etude preliminaire du dosage urinaire de l'hormone de croissance chez l'adulte sain : interet dans les dysfonctionnements de l'axe somatotrope." Reims, 1992. http://www.theses.fr/1992REIMM042.

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36

DELEBARRE, GENEVIEVE. "Utilisation therapeutique de l'hormone de croissance humaine biosynthetique dans le retard de croissance a debut intra uterin." Lille 2, 1994. http://www.theses.fr/1994LIL2M118.

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37

CARLO, CHRISTIAN. "L'hormone de croissance dans le traitement du syndrome de turner." Aix-Marseille 2, 1990. http://www.theses.fr/1990AIX20006.

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38

Feng, Xiaopeng. "Chicken growth hormone receptor and growth hormone : search for genetic variants which affect commercially important traits." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=42028.

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Chicken genomic DNA containing 5 kb of the 5$ sp prime$ end of the growth hormone (GH) receptor gene and 12 kb of the region up-stream was cloned and a restriction map was constructed. Using subcloned fragments as probes, a HindIII polymorphism was detected in both egg layer and in meat-type chickens. This polymorphic site was mapped at 7 kb up-stream of the coding region of the GH-receptor gene and a PCR assay for the polymorphism was developed to facilitate genotyping of large numbers of chickens.<br>Alleles of the GH-receptor gene and the GH gene were analyzed for association with traits in

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39

Chow, Chun-hung. "Characterization of a growth hormone gene in goldfish, Carassius Auratus /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2056658X.

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40

Fung, Tsz-kin Alvin. "Expression of two growth hormone genes in goldfish pituitary /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20442877.

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41

Lee, Jin-Sook. "Comparative study of immunocytochemical patterns of somatotrophs, mammotrophs, and mammosomatotrophs in the porcine anterior pituitary." [Ames, Iowa : Iowa State University], 2006.

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42

Pertuit, Morgane. "Rôle central des MAPKinases ERK1/2 dans la physiopathologie somatotrope : implication des altérations de Gsα". Aix-Marseille 2, 2009. http://www.theses.fr/2009AIX20735.

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L’hypophyse contrôle l’ensemble du système endocrinien en intégrant des informations diverses (centrales, périphériques et paracrines). Une bonne coordination des protéines du réseau de signalisation intracellulaire des cellules hypophysaires est le garant du bon fonctionnement de ce système. Au sein de ce réseau, la voie des MAPKinases ERK1/2 apparaît comme un point de convergence et d’intégration des signaux extracellulaires régulant la fonction hypophysaire somatotrope (expression génique, sécrétion hormonale). Les travaux précédents du groupe, réalisés dans la lignée cellulaire somatolacto

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43

VITON, LESCHELLE CAROLINE. "Effet d'un analogue de la somatostatine sur la fonction somatotrophe et la retinopathie du diabetique." Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX20808.

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44

Marty, Bruno Josef. "Dietary fat supplementation for dairy cows in early lactation injected with somatotropin." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59537.

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Dairy cows fed diets supplemented with 2.5% calcium-salt fatty acids (CSFA) (DM basis) during early lactation produced more 4% FCM than cows fed the control diet. Feeding this diet also increased whole lactation performance. Supplementing diets with 1.25% CSFA or animal fat did not increase production performance of cows. Dietary fats were used directly for greater milk production and, based on unchanged body condition scores, did not alleviate body fat mobilization. Changes in the milk fat content and composition due to fat supplemented diets were negligible. A slight decrease in milk protein

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45

Ramzan, Mohammed Arshad. "Limited proteolysis as a probe for the conformation of recombinant bovine somatotropin." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333714.

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46

LOCARD, BISOT SEGOLENE. "Effet d'un analogue de la somatostatine sur la taille des adenomes somatotropes." Lyon 1, 1991. http://www.theses.fr/1991LYO1M108.

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47

Bacciarini, Luca Nicola. "Effects of aging on the rat somatotrope and lactotrope cell population : an immunomorphometrical electron microscopical study /." [S.l.] : [s.n.], 1995. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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48

Guinot, Michel. "Suivi endocrininen des sportifs de haut niveau : axes hypothalamo-hypophyso-surrénalien et somatotrope et remodelage osseux." Université Joseph Fourier (Grenoble), 2005. http://www.theses.fr/2005GRE10247.

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Alors que la pratique reguliere de l'activite physique entraine de nombreux benefices, le sportif de haut niveau developpe plus frequemment des conduites a risque susceptibles de menacer sa sante. En particulier, l'utilisation de produits hormonaux (glucocorticoides, hormone de croissance) et les troubles du comportement alimentaire peuvent alterer le fonctionnement des axes corticotropes, somatotrope et du remodelage osseux. La physiopathologie de ces axes ayant ete peu etudiee chez les sportifs de haut niveau, l'objectif de ce travail a ete d'en realiser un etat des lieux a l'aide de dosages

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49

CHAUCOT, PHILIPPE. "Acromegalie a gh normale." Clermont-Ferrand 1, 1991. http://www.theses.fr/1991CLF13078.

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50

Marquet, Françoise. "Etude des resultats a long terme du traitement d'une serie de 18 patients operes d'un adenome hypophysaire a g. H." Clermont-Ferrand 1, 1991. http://www.theses.fr/1991CLF13076.

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