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Journal articles on the topic 'Somnifera'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Anni, Anni. "Phytochemical Profiling of Withania somnifera for Qualitative and Quantitative Study of Bioactive Component Withaferin a by High-Performance Liquid Chromatography." Bioscience Biotechnology Research Communications 18, no. 1 (2025): 67–71. https://doi.org/10.21786/bbrc/18.1.10.

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Over the past few years, the attention of people has changed from man-made (synthetic) to natural medicines. Withania somnifera’s phytochemical analysis has identified the presence of withanolides, which are pharmacologically active steroidal lactones. The two main withanolides that were isolated from Withania somnifera in India were withanolide D and withaferin A, both of which demonstrated cytotoxic and anticancer effects. The present investigation aimed to evolve a standard phytochemical profiling of Withania somnifera for the presence of withaferin A. The dried root sample was minced and g

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Lerose, Valentina, Maria Ponticelli, Nadia Benedetto, et al. "Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review." Plants 13, no. 6 (2024): 771. http://dx.doi.org/10.3390/plants13060771.

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Withania somnifera (L.) Dunal is a medicinal plant belonging to the traditional Indian medical system, showing various therapeutic effects such as anti-cancer, anti-inflammatory, anti-microbial, anti-diabetic, and hepatoprotective activity. Of great interest is W. somnifera’s potential beneficial effect against neurodegenerative diseases, since the authorized medicinal treatments can only delay disease progression and provide symptomatic relief and are not without side effects. A systematic search of PubMed and Scopus databases was performed to identify preclinical and clinical studies focusin

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Sørensen, Elin Tanding. "SOMNIFERA." Design/Arts/Culture 3, no. 1 (2023): 103–10. http://dx.doi.org/10.12681/dac.31472.

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“Somnifera” explores interactions between the opium poppy and humans. In their exploration of new habitats, human tribes curiously tested out plants that could help them transcend their “normal” state into expanded experiences, possibly communicating with their ancestors or gods, as part of their experimental quest for knowledge. Since the dawn of time, we have milked the benefits of the opium plant, while politics, religion, and a cynical multinational drug and pharmaceutical industry have assigned the plant a controversial role on the world stage. The plant’s power to both save life and take

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Mahdi, Abbas Ali, Kamla Kant Shukla, Mohammad Kaleem Ahmad, et al. "Withania somniferaImproves Semen Quality in Stress-Related Male Fertility." Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–9. http://dx.doi.org/10.1093/ecam/nep138.

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Stress has been reported to be a causative factor for male infertility.Withania somniferahas been documented in Ayurveda and Unani medicine system for its stress-combating properties. However, limited scientific literature is available on this aspect ofW. somnifera. We undertook the present study to understand the role of stress in male infertility, and to test the ability ofW. somniferato combat stress and treat male infertility. We selected normozoospermic but infertile individuals (N= 60), further categorized in three groups: normozoospermic heavy smokers (N= 20), normozoospermics under psy

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Adhikari, Lokesh, Rupali Kotiyal, Mukesh Pandey, Meenakshi Bharkatiya, Ajay Sematy, and Mona Semalty. "Effect of Geographical Location and Type of Extract on Total Phenol/Flavon Contents and Antioxidant Activity of Different Fruits Extracts of Withania somnifera." Current Drug Discovery Technologies 17, no. 1 (2020): 92–99. http://dx.doi.org/10.2174/1570163815666180807100456.

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Background:Withania somnifera (family solanaceae) is a well-investigated medicinal plant which is also called Indian ginseng due to its wide spectrum of medicinal properties. The contents and activity of the plant may vary depending on the habitat and part of the plant and the solvent used for extraction. The present study deals with the comparative chemical analysis and in vitro antioxidant activity of methanolic fruits extracts and its subfractions (in ethyl acetate, butanol and water) of W. somnifera collected from two different geographical locations.Methods:In the present study, Withania

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Basudkar, Vivek, Gunjan Gujrati, Saiprasad Ajgaonkar, Manav Gandhi, Dilip Mehta, and Sujit Nair. "Emerging Vistas for the Nutraceutical Withania somnifera in Inflammaging." Pharmaceuticals 17, no. 5 (2024): 597. http://dx.doi.org/10.3390/ph17050597.

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Inflammaging, a coexistence of inflammation and aging, is a persistent, systemic, low-grade inflammation seen in the geriatric population. Various natural compounds have been greatly explored for their potential role in preventing and treating inflammaging. Withania somnifera has been used for thousands of years in traditional medicine as a nutraceutical for its numerous health benefits including regenerative and adaptogenic effects. Recent preclinical and clinical studies on the role of Withania somnifera and its active compounds in treating aging, inflammation, and oxidative stress have show

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&NA;. "Withania somnifera." Reactions Weekly &NA;, no. 1400 (2012): 40. http://dx.doi.org/10.2165/00128415-201214000-00151.

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Jamalludin, Nurul Bariah, and Nurhuda Manshoor. "Ethnobotanical importance, phytochemical constituents, and pharmacological properties of Withania somnifera." Journal of Herbmed Pharmacology 11, no. 3 (2022): 320–29. http://dx.doi.org/10.34172/jhp.2022.37.

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Withania somnifera belongs to the family of Solanaceae. It is widely used by the locals, especially in India, as a medicinal plant. W. somnifera is rich in alkaloid and steroidal lactone that account for various pharmacological activities. The present study aimed to review all the evidence on the ethnobotanical perspective of W. somnifera in some countries. This review also analyses the bioactive compounds that account for the pharmacological activities. The online medical literature databases such as ScienceDirect, PubMed, and Google Scholar were used to search articles up to March 2022. W. s

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Narra, Haribabu. "Tissue Culture Studies in Withania Somnifera (L.) Dunal." Plantae Scientia 3, no. 6 (2020): 95–98. http://dx.doi.org/10.32439/ps.v3i6.95-98.

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Withania somnifera is an important medicinal herb that has been widely used for the treatment of different clinical conditions. The overall medicinal properties of Withania somnifera make it a viable therapeutic agent for addressing anxiety, cancer, microbial infection, immunomodulation, and neurodegenerative disorders. Biochemical constituents of Withania somnifera like withanolide A, withanolide D, withaferin A and withaniamides play an important role in its pharmacological properties. Proteins like Withania somnifera glycoprotein and withania lectin like-protein possess potent therapeutic p

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Tehri, Kanika, and Rachna Gulati. "Field efficacy of some biorationals against the two spotted spider mite Tetranychus urticae Koch (Acari: Tetranychidae)." Journal of Applied and Natural Science 6, no. 1 (2014): 62–67. http://dx.doi.org/10.31018/jans.v6i1.376.

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Field trials were conducted to evaluate the acaricidal potential of entomopathogenic fungus, Beauveria bassiana and aqueous extracts of Withania somnifera and Glyccirrhyza glabra against the mobile stages of Tetranychus urticae Koch on cucumber. The treatments responded in a concentration dependent manner. Highest reduction in T. urticae population was achieved with Omite (0.05%) followed by Nimbecidine (5ml/l), B. bassiana (1010 spores ml-1), W. somnifera (7.5%), B. bassiana (108 spores ml-1), G. Glabra (7.5%), G. Glabra (5%), G. Glabra (2.5%), W. somnifera (5%) and W. somnifera (2.5%). Highe

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Jassal, Prabhjot Singh, and Gagandeep Kaur. "COMPARATIVE ANALYSIS OF ANTIOXIDANT ACTIVITY AND PHYTOCHEMICAL CONTENTS IN ETHANOLIC LEAF EXTRACTS OF IN VITRO AND FIELD GROWN WITHANIA SOMNIFERA." Asian Journal of Pharmaceutical and Clinical Research 9, no. 5 (2016): 239. http://dx.doi.org/10.22159/ajpcr.2016.v9i5.13370.

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ABSTRACTObjective: The present study was planned to compare antioxidant activity in vitro and field grown Withania somnifera was assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide (NO) assays. Medicinal plants are a major source of phytochemicals used for the treatments ofhuman diseases. W. somnifera has anti-inflammatory, antioxidant, and antimicrobial properties.Methods: Antioxidant activity and phytochemical contents in W. somnifera were determined spectrophotometrically.Results: The results of antioxidant activity of field grown ethanolic leaf extract of W. somnifera show

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Kumar, Aman. "META-ANALYSIS OF DISEASES CAUSING FACTORS IN ASHWAGANDHA." International Journal of Engineering Applied Sciences and Technology 7, no. 5 (2022): 241–51. http://dx.doi.org/10.33564/ijeast.2022.v07i05.040.

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Ashwagandha scientifically known as Withania somnifera described in Ayurveda as a powerful rejuvenating herbal medicine. Their roots are thick and whitish brown, the leaves are somewhat oval in shape, hairless, and small. Withania somnifera is pharmacology as an adaptogen, antibiotic, abortion, aphrodisiac, astringent, anti-inflammatory, obtrusive, diuretic, narcotic, sedative, tonic, etc. Ashwagandha has been found to provide strong antioxidant protection. It stimulates the activation of immune system cells such as lymphocytes and phagocytic cells. Withania somnifera (L.) Dunal has been used

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Pandey, Umesh Chandra, Karunakar Shukla, and Rakesh Kumar Jatav. "Pharmacognostical, Phytochemical Screening and Evaluation of Anxiolytic activity of Alcoholic Extract of Withania somnifera (L) Dunal Roots." Journal of Drug Delivery and Therapeutics 13, no. 5 (2023): 29–34. http://dx.doi.org/10.22270/jddt.v13i5.5806.

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The roots of Withania somnifera (L) Dunal (W. somnifera) are used extensively in Ayurveda, the classical Indian system of medicine, and W. somnifera is categorized as a rasayana, which are used to promote physical and mental health, to provide defense against disease and adverse environmental factors and to arrest the aging process. W. somnifera has been used to stabilize mood in patients with behavioural disturbances. The objective of this study was to investigate pharmacognostical, phytochemical features and anxiolytic activity of alcoholic extracts of W. somnifera roots. The various pharmac

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Siddique, Anwar. "Ashwagandha (Withania somnifera)." Heilpflanzen 02, no. 04 (2022): 54–59. http://dx.doi.org/10.1055/a-1742-8485.

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Siddique, Anwar. "Ashwagandha (Withania somnifera)." Deutsche Heilpraktiker-Zeitschrift 19, no. 02 (2024): 60–64. http://dx.doi.org/10.1055/a-2273-3772.

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SummaryAshwagandha ist Sanskrit und bedeutet „Pferdegeruch“. Der wissenschaftliche Name dieser Pflanze ist Withania somnifera. Sie gehört zur Familie der Nachtschattengewächse (Solanaceae), wie Kartoffel, Aubergine, Tomate, Bittersüßer Nachtschatten (Solanum dulcamara) und Tollkirsche (Atropa belladonna). Bei uns wird Ashwagandha auch Indischer Ginseng, Schlafbeere oder winter cherry genannt.

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Gaurav, Harshita, Divyanshu Yadav, Ankita Maurya, et al. "Biodiversity, Biochemical Profiling, and Pharmaco-Commercial Applications of Withania somnifera: A Review." Molecules 28, no. 3 (2023): 1208. http://dx.doi.org/10.3390/molecules28031208.

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Withania somnifera L. Dunal (Ashwagandha), a key medicinal plant native to India, is used globally to manage various ailments. This review focuses on the traditional uses, botany, phytochemistry, and pharmacological advances of its plant-derived constituents. It has been reported that at least 62 crucial and 48 inferior primary and secondary metabolites are present in the W. somnifera leaves, and 29 among these found in its roots and leaves are chiefly steroidal compounds, steroidal lactones, alkaloids, amino acids, etc. In addition, the whole shrub parts possess various medicinal activities s

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N., Srilekha, P. Sabina E., Lalitha S., Selvam P., Vidya R., and Arunai Nambi Raj N. "Studies on induction of organic crystals in Wistar rat models and its interaction with Withania somnifera." Journal of Indian Chemical Society Vol. 92, Apr 2015 (2015): 600–602. https://doi.org/10.5281/zenodo.5597053.

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School of Biosciences and Technology, VIT University, Vellore-632 014, Tamilnadu, India <em>E-mail </em>: rvidya@vit.ac.in School of Advanced Sciences, VIT University, Vellore-632 014, Tamilnadu, India The study was carried out to know the effect of in Withania somnifera to control the induced renal crystals in Wistar rats and also to know the effect of the induced chemical (ethylene glycol) in the metabolism of the tested animals. In this study the renal stones (crystals) were induced in the animals by introducing ethylene glycol and allow it to counteract with Withania somnifera. The main fo

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Hammood, Mahmood Neamah, Liqaa Hasson Saqban, and Nazar Jebar Metib. "Protective Role of Withania somnifera Against the Adverse Effects of Levofloxacin on Testes Tissue of Rats In Vivo." Medical Journal of Babylon 22, no. 1 (2025): 41–49. https://doi.org/10.4103/mjbl.mjbl_174_23.

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Abstract Background: Medicinal plants have many uses in traditional medicine in all cultures due to their unique therapeutic properties. Withania somnifera is considered an agent to improve sexual health, an antioxidant, anti-aging, and anti-inflammatory. Objective: This study aimed to determine the therapeutic effect of W. somnifera on the potential Levofloxacin-induced testicular injury in rats. Materials and Methods: Thirty adult male Wistar rats were randomly divided into five groups: control group (C), saline-treated for 60 days. Group (W) W. somnifera root extract was orally treated for

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Shrivastava, A.K. Upadhyay V.B. Gautam D.S. Sarvade S. and Sahu R.K. "Effect of integrated nutrient management on growth and productivity of Withania somnifera (L.) Dunal in Kymore Plateau and Satpura hills of Madhya Pradesh, India." Archives of Agriculture and Environmental Science 3, no. 2 (2018): 202–8. https://doi.org/10.26832/24566632.2018.0302015.

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The field experiment was carried out at the Dusty Acres Farm, Jawaharlal Nehru Krishi Vishwa Vidyalaya (JNKVV), Jabalpur, Madhya Pradesh to study the effect of integrated nutrient management for growth and yield of <em>Withania somnifera </em>(L.) Dunal (Variety: Jawahar Ashwagandha-134). Tallest plants (49.35 cm) were observed at harvest stage, whereas higher number of branches per plant (5.78) of <em>W. somnifera </em>was observed at 90 DAS with T11, respectively. The mean number of leaves per plant (125.40) and LAI (10.345) of <em>W. somnifera </em>was higher a

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Sharma, Vibhuti, Rutika Sehgal, and Reena Gupta. "Withania somnifera: A potential rejuvenator of medicinal system for healthcare." Journal of Drug Delivery and Therapeutics 14, no. 4 (2024): 145–54. http://dx.doi.org/10.22270/jddt.v14i4.6536.

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Medicinal herbs have been used since the time of the Vedas. The plants have therapeutic qualities in every part. Secondary metabolites of extensive variety are present in medicinal plants and are utilised in the production of medications as well as in the treatment of many different ailments. Withania somnifera is a medicinal plant, have various properties. 'Ashwagandha' is the popular name of Withania somnifera. It is offered as churna, a finely sieved powder that can be combined with ghee, water or honey. It has memory-enhancing, anti-oxidant, anti-stress, anti-venom, anti-inflammatory and a

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Abu Zaid, Mohammad, Maheshwar Chauhan, and Swarndeep Chauhan. "Protective role of Withania somnifera root extract on lipid peroxidation of Erythrocytes." Universities' Journal of Phytochemistry and Ayurvedic Heights II, no. 33 (2022): 1–8. http://dx.doi.org/10.51129/ujpah-2022-33-2(1).

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Withania Somnifera (Ashwagandha) is an important medicinal plant that has been used in Ayurvedic and indigenous medicine. It is also known as Indian ginseng. It exerts antioxidant, anti-inflammatory and immune modulatory activities. In the present study, we studied the free radical scavenging activity of Withania Somnifera root extract. The radical scavenging effect of the extract was studied by its effect on hydroxy radicals generated by Fe-ascorbate-H2O2 system. Our results showed that Withania Somnifera root extract (1-10,000 µg/ ml) resulted in a significant dose dependent increase in perc

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Kumar, Ravi, Rajat Dhariwal, Anurag Kumar, and Miss Minata. "Effect of Withania Somnifera (L.) root extract\'s on PC12 induced by hydrogen peroxide, study." Journal of Pharmaceutical and Biological Sciences 10, no. 2 (2023): 79–82. http://dx.doi.org/10.18231/j.jpbs.2022.015.

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The L. is also used as a crude medicament that mostly effected in various neurological and immunological disorders. It is also known as Ashwagandha and “Indian ginseng” in Indian region. There is a lack of information on the possible neuroprotective properties of W. somnifera root against HO- and Ab(1-42)-induced cytotoxicity, which are now targeted for innovative treatments for dementia, particularly dementia of the Alzheimer's type (AD). According to this research, we prepared an aqueous extract of dried roots of W. somnifera that possess the protective effect against Ab- aggregated fibril a

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Sabir, Farzana, Anil Kumar, Pragya Tiwari, et al. "Bioconversion of Artemisinin to its Nonperoxidic Derivative Deoxyartemisinin through Suspension Cultures of Withania somnifera Dunal." Zeitschrift für Naturforschung C 65, no. 9-10 (2010): 607–12. http://dx.doi.org/10.1515/znc-2010-9-1013.

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Biotransformation of artemisinin was investigated with two different cell lines of suspension cultures of Withania somnifera. Both cell lines exhibited potential to transform artemisinin into its nonperoxidic analogue, deoxyartemisinin, by eliminating the peroxo bridge of artemisinin. The enzyme involved in the reaction is assumed to be artemisinin peroxidase, and its activity in extracts of W. somnifera leaves was detected. Thus, the non-native cell-free extract of W. somnifera and suspension culture-mediated bioconversion can be a promising tool for further manipulation of pharmaceutical com

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Padhye, Mugdha Rajeeva, Sangita Devrao Jogdand, and Jagruti Bhattacharjee. "Evaluation and comparison of nephroprotective effect of Hemidesmus indicus Linn. and Withania somnifera Linn. on gentamicin induced nephrotoxicity in Albino rats." International Journal of Basic & Clinical Pharmacology 7, no. 4 (2018): 691. http://dx.doi.org/10.18203/2319-2003.ijbcp20181171.

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Background: Nephrotoxicity is a known deleterious effect of Aminoglycoside antibiotics. This class of antibiotics is used very frequently. It is well known that Gentamicin causes renal tubular necrosis in the proximal tubular cells. Phytochemicals are being studied extensively and have proved to be of benefit in various diseases. The use of phytochemicals would minimize the adverse effects encountered with these antibiotics. Comparison between various phytochemicals would help in optimizing dosage and duration of treatment. In the present study we studied and compared the nephroprotective effe

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Ratti, Neelima, and Avinash Upadhyay. "Influence of Glomus intraradices on growth, biochemical changes and withanolides content of Withania somnifera L Dunal (Ashwagandha)." Environment Conservation Journal 14, no. 1&2 (2013): 75–80. http://dx.doi.org/10.36953/ecj.2013.141213.

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Withania somnifera L. Dunal (Ashwagandha) also known as Indian ginseng, of the family Solanaceae is an important ancient medicinal plant, used in the Indian traditional system of medicine. The medicinal importance of W. somnifera is attributed to the presence of steroidal lactones called withanolides which are present in the leaves and roots of the herb. The present set of pot experiment was designed to investigate the effect of Glomus intraradices inoculation on growth, biochemical parameters and withanolides content of W. somnifera. The results showed significant enhancement on plant growth,

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Naveen, Gaurav A. P. Singh and U.K. Chauhan. "Germination and Viability Capacity of Seeds of Withania somnifera (L.) Dunal." International Journal of Current Science Research (IJCSR) 1, no. 4 (2015): 67–70. https://doi.org/10.5281/zenodo.14626257.

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Abstract Rate of germination of seed of <em>Withania somnifera</em>, is usually different in different species varieties or members of <em>Withania somnifera</em> L. Dunal (Ashwagandha) (Sharma, <em>et.al</em>., 2015). The mycoflora percentage of seed is also about different in different species of Ashwagandha. (Ingle & Kareppa, 2009). <em>Withania somnifera</em> (L.) Dunal (Solanaceae) is generally reproduced by seeds. The percentage of germination is low, because of the presence of some inhibitory substances in the fruit. Among all the local and Indian culti

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Mikhaylova, E. V. "Prospects for the application of the medicinal plant Withania somnifera for biotechnological production of pharmaceuticals." Biomics 14, no. 3 (2022): 192–208. http://dx.doi.org/10.31301/2221-6197.bmcs.2022-14.

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Withania somnifera (L.) Dunal, also known as ashwagandha or Indian ginseng, is widely used in traditional oriental medicine. Modern research confirms the applicability of withanolides and other compounds from withania roots in treatment of various diseases. However, the massive gathering of W. somnifera for the purposes of traditional medicine puts the species at risk of extinction. Since this plant is sensitive to climatic conditions, production of W. somnifera hairy root cultures in bioreactors is the most promising cultivation method. This method allows to produce biomaterial of high purity

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Sukumar, Bargale Sushant, Tripathy T. B., and Shashirekha H.K. "Phyto physico-chemical profile of Ashwagandha (Withania somnifera Dunal)." Journal of Ayurveda and Integrated Medical Sciences (JAIMS) 5, no. 06 (2020): 120–29. http://dx.doi.org/10.21760/jaims.5.6.17.

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Introduction: The present article deals with study of phytochemical analysis of Withania somnifera Dunal roots. Ashwagandha (Withania somnifera Dunal - Solanaceae), The use of Ashwagandha (WS) is increasing due to a number of chemical constituents present in are found useful for promotion of health. Important bio-active constituents of Ashwagandha root powder are alkaloids, tannins and flavonoid and phenolic compound helps to promote the health benefits. Objective: Evolution of Physico- chemical and phyto chemical analysis of Ashwagandha (WS) powder. Materials and methods: The current investig

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Nagappan, Arulkumar, Nithya Karunanithi, Sundareswaran Sentrayaperumal, et al. "Comparative Root Protein Profiles of Korean Ginseng (Panax ginseng) and Indian Ginseng (Withania somnifera)." American Journal of Chinese Medicine 40, no. 01 (2012): 203–18. http://dx.doi.org/10.1142/s0192415x12500164.

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Ginsenosides and withanolides are the secondary metabolites from Panax ginseng and Withania somnifera, respectively. These compounds have similar biological properties. Two-dimensional electrophoresis (2-DE) analysis was utilized to reveal the protein profile in the roots of both plants, with the aim of clarifying similarly- and differentially-expressed proteins. Total proteins of Korea ginseng (P. ginseng) and Indian ginseng (W. somnifera) roots were separated by 2-DE using a pH 4–7 immobilized pH gradient strip in the first dimension and 12% sodium dodecyl sulfate polyacrylamide gel electrop

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Devaraj Reddy KN, Srilakshmi Aluri, Prathvi Shetty, et al. "Assessing the Efficacy and Biological Benefits of Withanolide-rich Withania somnifera Root Extract." Annual Research & Review in Biology 39, no. 5 (2024): 54–64. http://dx.doi.org/10.9734/arrb/2024/v39i52081.

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The medicinal plant Withania somnifera, usually referred to as Ashwagandha, is a member of the Solanaceae family. The presence of Withanolides in the roots is responsible for a number of pharmacological effects in Ashwagandha. Withanolides have been demonstrated to be an effective neuronal, immune, anti-stress, and anti-cancer agent. However, Withanolides demonstrated limited permeability, lowering the bioavailability and efficacy of active compounds. The goal of the study was to ascertain the biological efficacy of Ashwagandha Composition, a blend of W. somnifera milk extract and water extrac

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Gaurav, Isha, Tanuja Singh, Abhimanyu Thakur, et al. "Synthesis, In-Vitro and In-Silico Evaluation of Silver Nanoparticles with Root Extract of Withania somnifera for Antibacterial Activity via Binding of Penicillin-Binding Protein-4." Current Pharmaceutical Biotechnology 21, no. 15 (2020): 1674–87. http://dx.doi.org/10.2174/1389201021666200702152000.

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Background: Metal Nanoparticles (NPs) have been widely used for various applications in biomedical sciences, including in drug delivery, and as therapeutic agents, but limited owing to their toxicity towards the healthy tissue. This warrants an alternative method, which can achieve the desired activity with much reduced or no toxicity. Being a biological product, Withania somnifera (W. somnifera) is environment friendly, besides being less toxic as compared to metal-based NPs. However, the exact mechanism of action of W. somnifera for its antibacterial activities has not been studied so far. O

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Didio, Fábio Pieluhowski, André Rodrigues Duarte, and Giuseppe Potrick Stefani. "Effects of the Withania somnifera supplementation on sports performance: a systematic review and meta-analysis." North African Journal of Food and Nutrition Research 6, no. 13 (2022): 1–8. http://dx.doi.org/10.51745/najfnr.6.13.1-8.

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Background: Withania somnifera has been used as an ergogenic resource in recent years. In this scenario, a systematic literature review is justified to compile the findings in the scientific literature and to evaluate the methodological quality of these investigations. Aims: Our objective with this review was to evaluate the effects of Withania somnifera supplementation on sports performance in physical exercise practitioners. Material and Methods: This systematic literature review with meta-analysis addresses the effects of Withania somnifera supplementation on sports performance. Results: Of

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Bargale, Sushant Sukumar, T. B. Tripathy, and H. K. Shashirekha. "Phyto Physicochemical Profile of Withania somnifera Dunal (Solanaceae)." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 263–68. http://dx.doi.org/10.22270/jddt.v9i3-s.3008.

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Introduction- The present article deals with study of phytochemical analysis of Withania somnifera Dunal roots. Withania somnifera also known as Ashwagandha or winter cherry. Various preparations of Ashwagandha (WS) are available in the market used in the treatment of many clinical conditions in India. Objective- Evolution of Physico-chemical values and phytochemical analysis of Ashwagandha Churna. Materials and Methods- The current investigation deals with extraction and detection or screening of active phytochemical compounds from different extracts of Withania somnifera root. Pharmacognosti

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Gomathi Periyasamy, Hima Bindu Kasyap, Bharathi Nayaka, Srikala Rajala, and Prathyusha Segu. "Chemical and pharmacological review of Withania somnifera." World Journal of Biology Pharmacy and Health Sciences 16, no. 2 (2023): 165–72. http://dx.doi.org/10.30574/wjbphs.2023.16.2.0487.

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The Solanaceae family is comprised of 84 genera that include about 3,000 species, scattered throughout the world. Members of this family are generally annual shrubs. The genera Withania and Physalis play an important role in the indigenous medicine of South East Asia, e.g. in the Unani and Ayurvedic systems. Withania somnifera (L.) Dunal, (Solanaceae), commonly known as ashwagandha, winter cherry, Indian ginseng, or poison gooseberry. Traditionally it is commonly used in emaciation of children, hindrance from old age, rheumatism, vitiated conditions of vata, leucoderma, constipation, insomnia,

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Atta-ur-rahman, S. Arshad Jamal, M. Iqbal Choudhary, and Erfan Asif. "Two withanolides fromWithania somnifera." Phytochemistry 30, no. 11 (1991): 3824–26. http://dx.doi.org/10.1016/0031-9422(91)80125-k.

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Raj, Ben, and Madhan Shankar S. R. "Analysis Of Anticancer Activity And Its Molecular Interaction Mechanism Of Withanone, An Active Ingredient Of Withania Somnifera Using Molecular Docking." International Journal of pharma and Bio Sciences 11, no. 6 (2021): 35–41. http://dx.doi.org/10.22376/ijpbs/lpr.2021.11.6.l35-41.

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Withania somnifera is an annual evergreen shrub from the Solanaceae family, commonly known as Indian ginseng or Ashwagandha. The plant is mainly found in Asia and Africa regions. In the traditional Indian medicinal system ayurveda, Withania somnifera is used as a rejuvenator and sold in many countries as a dietary supplement. Withanolides are the major phytochemical constituent group found in the Withania somnifera, among which withaferin A and withanone, are considered to be major withanolides, which believed to be involved in majority of biological activity of Withania somnifera. Various stu

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Gupta, Lalita, and Meera Srivastava. "EFFECT OF WITHANIA SOMNIFERA EXTRACTS ON THE MORTALITY OF CALLOSOBRUCHUS CHINENSIS L." Journal of Biopesticides 01, no. 02 (2008): 190–92. http://dx.doi.org/10.57182/jbiopestic.1.2.190-192.

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ABSTRACT The present study was undertaken to study the effect of different extracts (agueous suspension, ether and water) of various parts of Withania somnifera (Solanaceae) against Callosobruchus chinensis L. A maximum of 63.33% adult mortality was observed in C.chinensis treated with 10% ether extracts of W. somnifera root.

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Sultana, Rajia, and Md Zakir Sultan. "In vitro Effect of Withania somnifera, Mucuna pruriens and Pausinystalia johimbe on Hepatic Cytochrome P450 in Rat." Bangladesh Pharmaceutical Journal 21, no. 2 (2018): 118–22. http://dx.doi.org/10.3329/bpj.v21i2.37922.

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The effect of Withania somnifera, Mucuna pruriens and Pausinystalia johimbe extracts on hepatic cytochrome P450 enzyme CYP3A4 activities was studied using rat liver microsomes. CYP3A4- dependent testosterone 6β-hydroxylation activities were determined by ELISA. In the study, rats were treated with W. somnifera (0.5 g/kg/day), M. pruriens (0.5 g/kg/day) and P. johimbe (0.25 g/kg/day) extracts for 20 days. It was found that W. somnifera, M. pruriens and P. johimbe extracts showed potent to moderate inhibitory effect on CYP3A4 activities in rat liver microsomes, with IC50 values of 18.01 ng/mL, 1

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Rege, A. A., P. R. Juvekar, and A. R. Juvekar. "IN VITRO LIPID PEROXIDATION INHIBITORY AND ANTI-ARTHRITIC ACTIVITIES OF SOME INDIAN MEDICINAL PLANTS." INDIAN DRUGS 49, no. 06 (2012): 31–35. http://dx.doi.org/10.53879/id.49.06.p0031.

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Anti-lipid peroxidation effect of aqueous extracts of Ocimum sanctum, Tinospora cordifolia and Withania somnifera was evaluated against Fe2+-ascorbic acid-induced lipid peroxidation using rat liver mitochondria as model system, whereas, anti-arthritic activity was evaluated by proteinase inhibitory assay. O. sanctum showed potent anti-lipid peroxidation and anti-arthritic activities. T. cordifolia exhibited moderate anti-lipid peroxidation activity, but considerable anti-arthritic activity, whereas, W. somnifera revealed least lipid peroxidation inhibitory activity and considerable anti-arthri

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Lungu, Petru Fabian, and Alin Ciobica. "A current review for some methodological aspects on using Crocus sativus and Whitania somnifera sp. extracts in the treatment of schizophrenia." Romanian Biotechnological Letters 28, no. 1/2023 (2023): 3835–40. http://dx.doi.org/10.25083/rbl/28.1/3835.3840.

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Schizophrenia is a severe mental illnes that affects population all around the world which poses a problem for the abilities of the affected person as well as their family members. Aim of the study: This narrative review has as its objective the potential evaluation of treatment with extracts from Crocus sativus and Whitania somnifera on patients with schizophrenia. Results: The plant extracts C. sativus and W. somnifera have a very well developed extraction method and beneficial effects in the case of patients with schizophrenia. Conclusion: Crocus sativus and Whitania somnifera extracts coul

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Sharma, Monica, Anand Gaur, Pinki Vishwakarma, Raj Kumar Goel, and K. K. Saxena. "Evaluation of hepatoprotective potential of aqueous extract of Withania somnifera in albino rats." International Journal of Basic & Clinical Pharmacology 10, no. 3 (2021): 255. http://dx.doi.org/10.18203/2319-2003.ijbcp20210477.

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Background: Hepatic diseases are a major cause of morbidity and disability of work force throughout the world. The treatment of hepatic diseases with standard drugs poses the risk of toxicity on various organ systems. Withania somnifera, a herbal plant has been claimed to be effective in the treatment of various types of hepatic conditions. The present study was undertaken to explore the hepatoprotective activity of aqueous extract of Withania somnifera (AEWS) in experimentally induced hepatotoxicity in albino rats.Methods: The study was commenced after obtaining approval from institutional an

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Srinu, Beesam, K. Kasturi Devi, and T. Madhava Rao. "Study on synergistic and antimicrobial activity of certain Bifidobacterium bifidum strains and plant extracts against clinical isolates." Journal of Phytopharmacology 13, no. 4 (2024): 294–97. http://dx.doi.org/10.31254/phyto.2024.13404.

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To evaluate the synergistic and antimicrobial activity of certain Bifidobacterium bifidum strains and methanolic extracts of Withania somnifera (Aswagandha) and Aloe vera plant extracts against clinical isolates from veterinary hospitals by using well diffusion method. The results obtained from the combined testing of Bifidobacterium adolescentis 236 strain and methanolic plant extracts of Withania somnifera showed significantly higher antibacterial/synergistic activity against isolates of E.coli and Staphylococcus aureus with an average zone of inhibition of 19.0 mm and 20.0 mm respectively,

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Alsabaa, Zein Husam, Luay Abu-Qatouseh, Kenza Mansoor, et al. "Pharmacokinetic and pharmacodynamic effects of Withania somnifera (L.) Dunal (ashwagandha) and carbamazepine combination in rats." Journal of Pharmacy & Pharmacognosy Research 13, no. 3 (2025): 925–32. https://doi.org/10.56499/jppres24.2088_13.3.925.

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Context: Withania somnifera, also known as ashwagandha, has antibacterial, anti-inflammatory, anticonvulsant, and anti-diabetic properties and reduces stress. Carbamazepine is one of the most used antiepileptic medications for treating epilepsy. Aims: To investigate the pharmacokinetics and pharmacodynamics of carbamazepine versus W. somnifera extract combination in vivo in healthy rat plasma using high-performance liquid chromatography. Methods: The carbamazepine levels were analyzed using validated high-performance liquid chromatography. The gamma-aminobutyric acid in the serum was performed

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Alsuhaimi, Nadia Mohammad, Mohammad Ajmal Ali, Mona Solaiman Alwahibi, et al. "Complete chloroplast genome sequence of a novel Withania somnifera (L.) Dunal: Comparative genomics and phylogenetic insights." Bangladesh Journal of Plant Taxonomy 31, no. 2 (2024): 205–23. https://doi.org/10.3329/bjpt.v31i2.78749.

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This study introduces a novel variety of the highly esteemed medicinal plant Withania somnifera (L.) Dunal from the family Solanaceae. The new variety, Withania somnifera var. abhaica Nadia, A. Ali & M.S. Alwahibi, var. nov., is distributed at high altitudes in the Abha hills of Saudi Arabia. The distinct characteristics of the novel variety of W. somnifera include elliptic-elongated leaves that are thick and semi-succulent in nature, and a fruiting calyx with a bifurcated tip measuring approximately 0.5 mm in length, with each bifurcated tip being botuliform in shape. Using next-generatio

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Gayozo, Elvio, Laura Rojas, and Liz Castro. "Acoplamiento molecular entre la proteína viral 1 del virus de la enfermedad infecciosa Bursal y fitoconstituyentes de Withania somnifera (L.) Dunal: Un enfoque computacional." Revista de Investigaciones Veterinarias del Perú 33, no. 5 (2022): e22022. http://dx.doi.org/10.15381/rivep.v33i5.22022.

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La enfermedad infecciosa bursal es una patología de origen viral que afecta a aves de corral ocasionando una alta tasa de mortalidad. Las vacunas existentes se enfrentan al problema de la aparición de nuevas cepas, por lo que se realizan búsquedas de moléculas con potencial afinidad de unión a proteínas virales. El extracto de Withania somnífera interviene en la replicación del virus de la bursitis infecciosa, pero el posible mecanismo de acción no es bien conocido. El objetivo de este estudio fue identificar a través de métodos in silico los fitoconstituyentes de W. somnifera con afinidad de

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SHUKLA, A., S. SRIVASTAVA, and K. DEV. "Review on chemistry, pharmacology, toxicity and future prospectives of withaferin A." Journal of Medicinal and Aromatic Plant Sciences 45, no. 3 (2023): 108–22. http://dx.doi.org/10.62029/jmaps.v45i3.shukla.

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The medicinal plant Withania somnifera is widely researched for its antiinflammatory,cardioprotective, and anticancer effects. W. somnifera preparations are specifically used to treat menstruation issues and arthritis in Ayurveda, the main traditional Indian medical system. The bioactive substance withaferin A (WA), a steroidal lactone, was first isolated from the leaves of W. somnifera. Numerous studies showed that WA contains various pharmacological properties, making it a good choice for treating various diseases. Its structural modification targets several signal transduction pathways and

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Gomathi, Periyasamy, Bindu Kasyap Hima, Nayaka Bharathi, Rajala Srikala, and Segu Prathyusha. "Chemical and pharmacological review of Withania somnifera." World Journal of Biology Pharmacy and Health Sciences 16, no. 2 (2023): 165–72. https://doi.org/10.5281/zenodo.10792440.

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<em>The Solanaceae family is comprised of 84 genera that include about 3,000 species, scattered throughout the world. Members of this family are generally annual shrubs. The genera Withania and Physalis play an important role in the indigenous medicine of South East Asia, e.g. in the Unani and Ayurvedic systems. Withania somnifera</em> (L.) Dunal, (Solanaceae), commonly known as ashwagandha, winter cherry, Indian ginseng, or poison gooseberry. Traditionally it is commonly used in emaciation of children, hindrance from old age, rheumatism, vitiated conditions of vata, leucoderma, constipat

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Nasr, Ullah Khan, Waqas Muhammad, tul Qubra Khadija, et al. "Assessing the Antioxidant Potential of Withania somnifera Leaf Extract via DPPH Assay." International Journal of Agricultural Innovations and Cutting-Edge Research (HEC Recognised) 2, no. 3 (2024): 90. https://doi.org/10.5281/zenodo.14685683.

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The rise of antimicrobial resistance has spurred interest in exploring natural sources for new antibiotics and antifungals. In this study, we investigated the antimicrobial and antifungal potential of <em>Withania somnifera</em> extracts against common pathogens. Various fractions (ethyl acetate, aqueous, hexane, and dichloromethane) were obtained from <em>Withania somnifera</em> and tested using agar well diffusion method against <em>Staphylococcus aureus, Escherichia coli</em>, and<em> Aspergillus fumigatus</em>. Similarly, strong antifungal activity was demonstrated against <em>A. fumigatus

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Munir, Naveed, Zahed Mahmood, Muhammad Shahid, et al. "Withania somnifera Chemical Constituents’ In Vitro Antioxidant Potential and Their Response on Spermatozoa Parameters." Dose-Response 20, no. 1 (2022): 155932582210749. http://dx.doi.org/10.1177/15593258221074936.

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Background: Phytomedicine is becoming more acceptable as an alternative medicinal approach in the modern era. Objectives: The current study examined the antioxidant capacity and in vitro response of phytochemical constituents of Withania somnifera (Ashwagandha) on standard parameters of healthy volunteer semen. Methods: The phytochemicals and their pharmacological response in a hydroethanolic (30:70 v/v) extract of W. somnifera roots were determined using standard protocols. Results: The constituents included flavonoids, phenolic acids, alkaloids, and terpenoids were reported. High-performance

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"Withania-somnifera." Reactions Weekly 1849, no. 1 (2021): 418. http://dx.doi.org/10.1007/s40278-021-93802-0.

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